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Recruiting Observational

ItAlian ReGistry Of pNeumoniA in immUnocompromised paTients (ARGONAUT)

NCT06755814 · tracked via the Priya Life Science Italy tracker
Sponsor
Societa Italiana di Pneumologia
Phase
Observational
Started
2025-08-11
Last updated
2025-11-18

Condition(s) studied

Community Acquired Pneumonia (CAP)

Study summary

This multicentric, prospective study aims at:

evaluating the prevalence, etiology, characteristics, and 1one-year outcomes of immunocompromised patients hospitalized for Community-Acquired Pneumonia (CAP); conducting biochemical, microbiological and genetic analysis on collected samples.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: Hospitalized patients with a confirmed diagnosis of Community-Acquired Pneumonia (CAP) characterized by at least one of the following risk factors for immunosuppression: * AIDS, * Aplastic anemia; * Asplenia; * Hematologic malignancy (e.g., lymphoma/acute or chronic myeloid leukemia/multiple myeloma); * Chemotherapy within the last 3 months; * Neutropenia defined as a white blood cell count less than 500/dL on a complete blood count; * Use of biologics (including trastuzumab and therapy for autoimmune diseases (e.g., anti-TNF α), prescribed within the last 6 months before hospital admission; * Solid organ transplant; * Bone marrow transplant; * Chronic oral steroid use (\>10 mg/day prednisone or equivalent ≥3 months before accessing the ED, or cumulative dose \> 600 mg prednisone); * Use of corticosteroid therapy with a dose ≥ 20 mg prednisone or equivalent ≥14 days or cumulative dose \> 600 mg prednisone; * Active malignancy; * Malignancy within one year of pneumonia (excluding patients with localized skin cancer or early-stage malignancy); * Lung malignancy with neutropenia/chemotherapy; * Other solid malignancy with neutropenia/chemotherapy; * Other immunodeficiency (including congenital/genetic immunosuppression and immunosuppressive therapy secondary to hematologic malignancy or solid malignancy); * Primary immunodeficiency. Exclusion Criteria: * None

Primary outcome measure(s)

  • In-hospital mortality for all causes in immunocompromised patients with CAP enrolled in the study. — During hospitalization corresponding to study enrollment (1 day to 2 weeks of hospitalization on average)
    Recording in-hospital mortality for all causes in immunocompromised patients with CAP enrolled in the study.

Trial sites (1)

FacilityCityRegionStatus
Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano Via Francesco Sforza 35 20122 Milan Italy Milan Milano Recruiting

More Societa Italiana di Pneumologia trials in Italy

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06755814 on ClinicalTrials.gov ↗ ← All trials in Italy