Clinical Trials in Italy / NCT06755814
Recruiting
Observational
ItAlian ReGistry Of pNeumoniA in immUnocompromised paTients (ARGONAUT)
NCT06755814 · tracked via the Priya Life Science Italy tracker
Condition(s) studied
Community Acquired Pneumonia (CAP)
Study summary
This multicentric, prospective study aims at:
evaluating the prevalence, etiology, characteristics, and 1one-year outcomes of immunocompromised patients hospitalized for Community-Acquired Pneumonia (CAP); conducting biochemical, microbiological and genetic analysis on collected samples.
Eligibility
Inclusion Criteria:
Hospitalized patients with a confirmed diagnosis of Community-Acquired Pneumonia (CAP) characterized by at least one of the following risk factors for immunosuppression:
* AIDS,
* Aplastic anemia;
* Asplenia;
* Hematologic malignancy (e.g., lymphoma/acute or chronic myeloid leukemia/multiple myeloma);
* Chemotherapy within the last 3 months;
* Neutropenia defined as a white blood cell count less than 500/dL on a complete blood count;
* Use of biologics (including trastuzumab and therapy for autoimmune diseases (e.g., anti-TNF α), prescribed within the last 6 months before hospital admission;
* Solid organ transplant;
* Bone marrow transplant;
* Chronic oral steroid use (\>10 mg/day prednisone or equivalent ≥3 months before accessing the ED, or cumulative dose \> 600 mg prednisone);
* Use of corticosteroid therapy with a dose ≥ 20 mg prednisone or equivalent ≥14 days or cumulative dose \> 600 mg prednisone;
* Active malignancy;
* Malignancy within one year of pneumonia (excluding patients with localized skin cancer or early-stage malignancy);
* Lung malignancy with neutropenia/chemotherapy;
* Other solid malignancy with neutropenia/chemotherapy;
* Other immunodeficiency (including congenital/genetic immunosuppression and immunosuppressive therapy secondary to hematologic malignancy or solid malignancy);
* Primary immunodeficiency.
Exclusion Criteria:
* None
Primary outcome measure(s)
- In-hospital mortality for all causes in immunocompromised patients with CAP enrolled in the study. — During hospitalization corresponding to study enrollment (1 day to 2 weeks of hospitalization on average)
Recording in-hospital mortality for all causes in immunocompromised patients with CAP enrolled in the study.
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano Via Francesco Sforza 35 20122 Milan Italy | Milan | Milano | Recruiting |
More Societa Italiana di Pneumologia trials in Italy
MANI Real-life Perspective Observatory
Recruiting
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06755814 on ClinicalTrials.gov ↗ ← All trials in Italy