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Clinical Trials in Italy / NCT07182539
Starting soon Not applicable

VCV vs PRVC in Pediatric Anesthesia; an EIT- and LS-based Study

NCT07182539 · tracked via the Priya Life Science Italy tracker
Sponsor
Vittore Buzzi Children's Hospital
Phase
Not applicable
Started
2025-09
Last updated
2025-09-19

Condition(s) studied

Atelectasis

Investigational drug(s) / intervention(s)

PRVC ventilationVCV ventilation

PRVC ventilation: Ventilation in PRVC mode.

VCV ventilation: Ventilation in VCV mode.

Study summary

The primary objective of this study is to evaluate and compare the incidence and severity of intraoperative pulmonary atelectasis, measured by Lung Ultrasound Score (LUS) and EIT (Electrical Impedance Tomography), between two different modes of mechanical ventilation: Volume Control Ventilation (VCV) and Pressure Regulated Volume Control (PRVC/PCV-VG)

Eligibility

Sex
ALL
Min age
3 Years
Max age
10 Years
Healthy volunteers
No
Inclusion Criteria: * Patients requiring intraoperative mechanical ventilation via endotracheal intubation * Written informed consent obtained from parents or legal guardians. For children capable of understanding, assent will also be obtained based on age and cognitive ability. * ASA (American Society of Anesthesiologists) physical status I-II Exclusion Criteria: * Patients with significant pre-existing lung disease (e.g., cystic fibrosis, severe bronchopulmonary dysplasia, severe uncontrolled asthma, neuromuscular disease with respiratory compromise). * Patients with complex congenital heart disease or significant hemodynamic instability. * Patients undergoing thoracic surgery or procedures that could significantly alter lung mechanics (e.g., pre-existing pneumothorax). * Refusal of parents/guardians or patient to participate in the study. * History of previous intrathoracic procedure.

Primary outcome measure(s)

  • Atelectasis at lung ultrasound — From baseline to recovery in post-anesthesia care unit
    To compare the incidence of intraoperative pulmonary atelectasis, measured by Lung Ultrasound Score (LUS) , between two different modes of mechanical ventilation: Volume Control Ventilation (VCV) and Pressure Regulated Volume Control (PRVC/PCV-VG).
  • Atelectasis — From baseline to recovery in post-anesthesia care unit
    To compare the severity of intraoperative pulmonary atelectasis, measured by EIT, between two different modes of mechanical ventilation: Volume Control Ventilation (VCV) and Pressure Regulated Volume Control (PRVC/PCV-VG).

Trial sites (1)

FacilityCityRegionStatus
Vittore Buzzi Children's Hospital Milan Italy
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07182539 on ClinicalTrials.gov ↗ ← All trials in Italy