Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

NCT06965023 · tracked via the Priya Life Science Italy tracker

Sponsor

Azienda Ospedaliera "Sant'Andrea"

Phase

Observational

Started

2025-04-22

Last updated

2025-05-11

Condition(s) studied

ST-elevation Myocardial Infarction (STEMI)MicroplasticsNanoplasticsPollution Exposure

Study summary

Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: All the following inclusion criteria should be fulfilled: 1. Age \> 18 years old; 2. STEMI undergoing urgent invasive coronary angiography; 3. Acute thrombotic coronary occlusion/sub-occlusion (TIMI 0/1); 4. Clinical indication to thromboaspiration; 5. Able to give informed consent. Exclusion Criteria: 1. Contraindications to percutaneous coronary intervention; 2. Hemodynamic instability or cardiogenic shock; 3. End-stage chronic kidney disease; 4. Life expectancy \< 1 year due to non-cardiac pathology.

Primary outcome measure(s)

Burden of micro- and nanoplastics (MNPs) in coronary thromboaspirate in STEMI patients. — From enrollment until the date of hospital discharge, assessed up to 7 days
To assess the burden of micro- and nanoplastics (MNPs) in coronary thromboaspirate of patients experiencing an ST-elevation myocardial infarction.
Correlation of micro- and nanoplastics (MNPs) in coronary thromboaspirate in STEMI patients with inflammatory and cardiac damage biomarkers. — From enrollment until the date of hospital discharge, assessed up to 7 days
To assess the correlation between the burden of micro- and nanoplastics (MNPs) in coronary thromboaspirate of patients experiencing an ST-elevation myocardial infarction with inflammatory, oxidative stress, and cardiac damage biomarkers of peripheral and coronary blood samples.

Trial sites (10)

Facility	City	Region	Status
Sant'Andrea University Hospital	Roma	Rome	Recruiting
Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli	Caserta	Italy	Active Not Recruiting
Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy.	Caserta	Italy	Not Yet Recruiting
Cardiovascular Department, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.	Catania	Italy	Not Yet Recruiting
Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy	Ferrara	Italy	Not Yet Recruiting
Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy.	Forlì	Italy	Not Yet Recruiting
Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy.	Milan	Italy	Not Yet Recruiting
Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy.	Naples	Italy	Active Not Recruiting
Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy.	Turin	Italy	Not Yet Recruiting
Azienda Ospedaliera Integrata Verona, Italy	Verona	Italy	Recruiting

More Azienda Ospedaliera "Sant'Andrea" trials in Italy

Derivation and Validation of the Aortic Valve Echocardiographic Calcium Score to Confirm Severe Aortic Stenosis: the Echo-AVCS Study Recruiting

Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes Recruiting

Other trials for the same condition

Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes Recruiting

Functional Milk Supplementation to Reduce In-Stent Restenosis in STEMI Patients (SMASOEA Trial) Starting soon

Environmental Pollutants and Life Quality Enrolling by invitation

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06965023 on ClinicalTrials.gov ↗ ← All trials in Italy