Personalization of External Beam Radiation Therapy in Localised Tumours

Condition(s) studied

Investigational drug(s) / intervention(s)

prostate patient: patients with prostate cancer treated with RT at IEO

breast patients: patients with breast cancer treated with RT at IEO

Study summary

The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT).

Within the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples/organoids will be irradiated with RT for biological validation.

Eligibility

Primary outcome measure(s)

• Generation of in-silico tumor model — 1 year
  generate an in-silico tumour model able to describe tumour microstructure and its interaction with the radiation beam
• Personalization of the tumour model with patient-specific MR imaging data — 1 year
  personalize the tumour model implemented in A1 with patient-specific MR imaging data for tumour characterization and treatment outcome prediction, relying on retrospective data
• Improvement of personalized tumor-models — 3 years
  Improvement of the implemented models, by relying on advanced agnetic Resonance Imaging (MRI) data acquired prospectively
• Evaluation of tumor model in describing the in-vivo microstructural and radiobiological characteristics — 3 years
  The evaluation of the implemented in-silico tumour model in describing the in-vivo microstructural and radiobiological characteristics, by collecting histopathological features and irradiating primary cell cultures.

Trial sites (1)

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