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Trackers› Clinical trials› Hamburg
Clinical trial register · Germany

Clinical Trials in Hamburg, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Germany and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 5051 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:51 UTC
5051
Studies in scope
all four open statuses
2882
Recruiting now
open to new participants
988
Lead sponsors
across recruiting studies
Top sites
Berlin 1584 Hamburg 889 Essen 760 Dresden 707 Heidelberg 627
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Recruitment status
Phase
Lead sponsor
Universitätsklinikum Hamburg-Eppendorf74 AstraZeneca56 Janssen Research & Development, LLC33 Eli Lilly and Company30 Novartis Pharmaceuticals26
Site location
Berlin1584 Hamburg889 Essen760 Dresden707 Heidelberg627
All 635 locations
Target enrolment
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Trials with a site in Hamburg

889 of 5051 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Germany
Start
Recruiting
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
NCT05727904Metastatic Melanoma, Unresectable Melanoma, Melanoma
DrugsLifileucel·Pembrolizumab
Iovance Biotherapeutics, Inc.
Phase 3
670
Berlin, Würzburg, Dresden, Hamburg, Lübeck, Munich
2023-03-30
Active, closed
A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma
NCT05572515Relapsed or Refractory Multiple Myeloma
DrugsTeclistamab·Carfilzomib·Pomalidomide·Bortezomib
Janssen Research & Development, LLC
Phase 3
614
Cottbus, Dresden, Greifswald, Hamburg, Heidelberg, Marburg, Tübingen, Ulm
2023-03-29
Active, closed
A Study of Secukinumab to Evaluate Maintenance of Response in Participants With Non-radiographic Axial Spondyloarthritis Who Achieved Remission
NCT05622708Non-radiographic Axial Spondyloarthritis
DrugSecukinumab
Novartis Pharmaceuticals
Phase 4
240
Bad Doberan, Berlin, Hamburg, Herne, Ratingen
2023-03-28
Active, closed
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
NCT05501873Atrial Fibrillation
Boston Scientific Corporation
Observational
1,173
Aachen, Dresden, Göttingen, Hamburg, Heidelberg, Karlsruhe, Münster
2023-03-24
Active, closed
DOR/ISL in HIV-1 Antiretroviral Treatment-naïve Participants (MK-8591A-053)
NCT05705349HIV-1 Infection
DrugsDOR/ISL·B/F/TAF
Merck Sharp & Dohme LLC
Phase 3
537
München, Freiburg, Bonn, Hamburg
2023-03-08
Recruiting
Tafasitamab (MOR00208) in Pediatric Patients With Relapsed or Refractory Acute B Lineage Leukemia
NCT05366218ALL, Childhood B-Cell, Acute Lymphoid Leukemia Relapse, Acute Lymphocytic Leukemia Refractory
DrugTafasitamab
University Hospital Tuebingen
Phase 1/2
20
Freiburg im Breisgau, Tübingen, Ulm, München, Hamburg, Düsseldorf, Berlin, Essen
2023-03-08
Recruiting
A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis
NCT06875336Extrapulmonary Tuberculosis
University of Cologne
Observational
150
Bonn, Borstel, Cologne, Frankfurt, Hamburg, Heidelberg
2023-03-06
Active, closed
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
NCT05669755Cardiovascular Disease
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
7,101
Dortmund, Dresden, Elsterwerda, Essen, Frankfurt, Hamburg, Heidelberg, Leipzig
2023-03-01
Recruiting
A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata
NCT05723198Areata Alopecia, Alopecia, Hypotrichosis, Hair Diseases
DrugBaricitinib
Eli Lilly and Company
Phase 3
595
Bad Bentheim, Berlin, Dresden, Frankfurt am Main, Hamburg, Mainz, München, Münster
2023-02-27
By invitation
An Extension Study of JR-141 to Evaluate the Long-term Safety and Efficacy in MPS II (Hunter Syndrome) Subjects
NCT05594992Mucopolysaccharidosis II
DrugJR-141
JCR Pharmaceuticals Co., Ltd.
Phase 3
80
Hamburg
2023-02-22
Recruiting
Psychometric Validation of the Camouflaging Autistic Traits Questionnaire
NCT05989685Autism Spectrum Disorder
Universitätsklinikum Hamburg-Eppendorf
Observational
622
Hamburg
2023-02-20
Recruiting
Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial
NCT05496998Mitral Regurgitation
Medtronic Cardiovascular
Not applicable
400
Bad Oeynhausen, Berlin, Bonn, Hamburg, Leipzig, Mainz, München, Ulm
2023-02-07
Recruiting
Expression-linked and R-ISS-adapted Stratification for First Line Therapy in Multiple Myeloma Patients
NCT05665140Newly Diagnosed Multiple Myeloma
DrugsVelcade·Isatuximab·Bortezomib·Lenalidomide
University Hopsital Schleswig Holstein Campus Lübeck
Phase 2/3
100
Berlin, Bielefeld, Hamburg, Lübeck, Münster, Würzburg
2023-02-03
Active, closed
A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adolescent or Adult Participants With Severe Hemophilia
NCT05662319Hemophilia
DrugsAntithrombin·Clotting factor concentrates·Fitusiran
Sanofi
Phase 3
91
Berlin, Hamburg
2023-02-01
Active, closed
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
NCT05478304Ischemic Stroke, Systemic Embolism
AtriCure, Inc.
Not applicable
6,573
Freiburg im Breisgau, Bad Neustadt an der Saale, Berlin, Bad Rothenfelde, Hamburg
2023-01-25
Active, closed
Proof of Concept Human Study: Dietary Intervention to Modify Intestinal Inflammation in IBD
NCT05867537Reduction of Intestinal Inflammatory Activity
Universitätsklinikum Hamburg-Eppendorf
Not applicable
20
Hamburg
2023-01-18
Recruiting
Alleviant ALLAY-HF Study
NCT05685303Heart Failure
Alleviant Medical, Inc.
Not applicable
700
Hamburg, Lübeck, Magdeburg
2023-01-10
Active, closed
Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
NCT05678673Non-Clear Cell Renal Cell Carcinoma
DrugsSunitinib Malate·Zanzalintinib·Sunitinib·Opdivo
Exelixis
Phase 3
317
Frankfurt am Main, Eisleben Lutherstadt, Hamburg
2023-01-01
Active, closed
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
NCT05595642Chronic Obstructive Pulmonary Disease (COPD)
DrugAstegolimab
Hoffmann-La Roche
Phase 3
1,290
Lübeck, Berlin, Darmstadt, Frankfurt, Hamburg, Hanover, Heidelberg, Immenhausen
2022-12-29
Active, closed
Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations
NCT05687266NSCLC
DrugsDato-DXd·Durvalumab·Pemetrexed·Paclitaxel
AstraZeneca
Phase 3
1,350
Bad Berka, Berlin, Frankfurt A. Main, Gauting, Gütersloh, Hamburg, Kassel, Kiel
2022-12-29
Recruiting
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
NCT05712200Atrial Fibrillation (AF)
DrugAbelacimab
Anthos Therapeutics, Inc.
Phase 3
2,500
Altenburg, Berlin, Dresden, Hamburg, Hanover, Ludwigshafen, Markkleeberg, Paderborn
2022-12-27
Recruiting
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
NCT05549297Advanced Melanoma
DrugTebentafusp
Immunocore Ltd
Phase 3
540
Schleswig, Berlin, Dresden, Erlangen, Essen, Hamburg, Heidelberg, Kiel
2022-12-19
Recruiting
SteamOne - Prospective Database for Rezum Water Vapor Therapy of the Prostate
NCT05495633Benign Prostate Obstruction (BPO)
University Hospital, Basel, Switzerland
Observational
1,000
Berlin, Frankfurt, Hamburg, Kiel, Krefeld, Nuremberg, Reinbek, Sindelfingen
2022-12-16
Active, closed
A Study of Daratumumab
NCT05438043Multiple Myeloma
DrugsCarfilzomib·Pomalidomide·Daratumumab·Lenalidomide
Janssen Research & Development, LLC
Phase 3
213
Chemnitz, Hamburg, Tübingen
2022-12-15
Active, closed
A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)
NCT05469737Myelodysplastic Syndromes
DrugAzacitidine
Bristol-Myers Squibb
Phase 2/3
230
Duisburg, Düsseldorf, Leipzig, Dresden, Hamburg, Mutlangen
2022-12-14
Recruiting
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
NCT05624450Viral Lung Infection and Acute Respiratory Failure
DrugTozorakimab
AstraZeneca
Phase 3
3,527
Augsburg, Berlin, Cologne, Hamburg, Hanover, Kiel, Leverkusen, Marburg
2022-12-13
Active, closed
A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma
NCT05529316Advanced Melanoma
DrugsBalstilimab·Botensilimab
Agenus Inc.
Phase 2
150
Essen, Hamburg, Heidelberg, Kiel, Mainz, München, Tübingen, Würzburg
2022-12-12
Active, closed
TARGET Study: Safety and Performance of the Cardiovalve TR Replacement System
NCT05486832Tricuspid Regurgitation
Cardiovalve Ltd.
Not applicable
157
Bad Oeynhausen, Berlin, Bonn, Cologne, Hamburg, Lübeck, Regensburg
2022-12-09
Active, closed
Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.
NCT05445843Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation
DrugOpnurasib
Novartis Pharmaceuticals
Phase 2
95
Kempten (Allgäu), Halle, Hamburg, Oldenburg, Tübingen
2022-12-06
By invitation
Safety, Tolerability and Efficacy of ICV AX 250 Treatment in MPS IIIB -OLE
NCT05492799MPS III B
Allievex Corporation
Phase 4
15
Hamburg
2022-12-02
Recruiting
GMMG-HD10 / DSMM-XX / 64007957MMY2003, MajesTEC-5
NCT05695508Multiple Myeloma
DrugsRamantamig·Talquetamab·Teclistamab·Bortezomib
University of Heidelberg Medical Center
Phase 2
160
Berlin, Chemnitz, Dresden, Düsseldorf, Freiburg im Breisgau, Hamburg, Heidelberg, Kiel
2022-12-01
Recruiting
HRS-AKI Treatment With TIPS in Patients With Cirrhosis
NCT05346393Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury, Ascites Hepatic
Jena University Hospital
Not applicable
124
Aachen, Berlin, Dresden, Essen, Freiburg im Breisgau, Halle, Hamburg, Hanover
2022-11-29
Active, closed
A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
NCT05629585Breast Cancer
DrugsDato-DXd·Xeloda·Durvalumab·Keytruda
AstraZeneca
Phase 3
1,174
Frankfurt am Main, Hamburg, Hanover, Heilbronn, Kiel, Langen, Leipzig, Ludwigsburg
2022-11-28
Recruiting
A Global, Multicenter Study to Assess Maternal, Fetal and Infant Outcomes of Exposure to Palynziq® (Pegvaliase) During Pregnancy and Breastfeeding
NCT05579548Phenylketonuria, Maternal
DrugPegvaliase
BioMarin Pharmaceutical
Observational
50
Hamburg
2022-11-22
Recruiting
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
NCT05623020Multiple Myeloma
DrugsElranatamab·Bortezomib·Daratumumab·Lenalidomide
Pfizer
Phase 3
1,060
Freiburg im Breisgau, Tübingen, Ulm, Mainz, Aachen, Braunschweig, Chemnitz, Hamburg
2022-11-10
Recruiting
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
NCT05457283Chronic Kidney Disease, Proteinuria, Children
DrugFinerenone
Bayer
Phase 3
100
Heidelberg, Hanover, Bonn, Essen, Münster, Berlin, Hamburg
2022-11-08
By invitation
The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD
NCT05374291Kidney Disease, Chronic, Renal Transplant Failure, Heart Failure, Kidney Failure
DrugDapagliflozin
University Medical Center Groningen
Phase 3
1,750
Berlin, Düsseldorf, Erlangen, Halle, Hamburg, Hanover, Heidelberg, Heilbronn
2022-11-08
Active, closed
Prospective Development and Validation of an Objective Classification for Difficult Facemask Ventilation: the MASCAN Score
NCT07275502Airway Management, Mask Ventilation, Noninvasive Ventilation
Universitätsklinikum Hamburg-Eppendorf
Observational
423
Hamburg
2022-11-07
Active, closed
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
NCT05567796Obesity
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
3,400
Bad Mergentheim, Elsterwerda, Essen, Hamburg, Leipzig, Münster, Stuttgart, Wangen
2022-11-01
Recruiting
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
NCT05552222Multiple Myeloma
DrugsTalquetamab·Teclistamab·Daratumumab·Lenalidomide
Janssen Research & Development, LLC
Phase 3
1,590
Berlin, Essen, Halle, Hamburg, Nuremberg, Tübingen, Würzburg
2022-10-25
Active, closed
A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp
NCT05387525Keratosis, Actinic
DrugDiclofenac Sodium
Almirall, S.A.
Phase 4
447
Augsburg, Bad Bentheim, Bochum, Bonn, Detmold, Dresden, Erlangen, Hamburg
2022-10-24
Active, closed
A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma
NCT05259839Relapsed/Refractory Multiple Myeloma
DrugsEtentamig·Pomalidomide·Daratumumab·Lenalidomide
AbbVie
Phase 1
283
Tübingen, Regensburg, Würzburg, Essen, Hamburg
2022-10-20
Active, closed
A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma
NCT05535244Multiple Myeloma
DrugsCevostamab·Tocilizumab
Hoffmann-La Roche
Phase 1/2
90
Cologne, Hamburg, Würzburg
2022-10-17
Active, closed
A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment
NCT05455320Multiple Myeloma
DrugsTalquetamab·Pomalidomide·Daratumumab·Dexamethasone
Janssen Research & Development, LLC
Phase 3
864
Berlin, Cologne, Hamburg, Heidelberg, Leipzig, Mainz, Würzburg
2022-10-13
Active, closed
Efficacy and Safety of AC102 Compared to Steroids in Adults With Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL)
NCT05776459Hearing Loss, Sensorineural
DrugPrednisolone
AudioCure Pharma GmbH
Phase 2
210
Bensheim, Berlin, Dresden, Greifswald, Halle, Hamburg, Jena, Mainz
2022-10-13
Active, closed
Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer
NCT05502237Non-small Cell Lung Cancer
DrugsDomvanalimab·Zimberelimab·Nab-paclitaxel·Pemetrexed
Gilead Sciences
Phase 3
1,021
Cologne, Essen, Großhansdorf, Halle, Hamburg, Hemer, Karlsruhe, Lübeck
2022-10-12
Active, closed
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
NCT05556512Obesity, Overweight
DrugTirzepatide
Eli Lilly and Company
Phase 3
15,374
Bad Homburg, Bad Oeynhausen, Berlin, Dresden, Essen, Frankfurt, Freiburg im Breisgau, Hamburg
2022-10-11
Active, closed
Omics Gaucher Study: Multiomic Approach
NCT05526664Gaucher Disease
CENTOGENE GmbH Rostock
Observational
25
Hamburg
2022-10-06
Recruiting
Intracoronary Stenting and Restenosis - Randomized Trial of Drug-eluting Stent Implantation or Drug-coated Balloon Angioplasty According to Neointima Morphology in Drug-eluting Stent Restenosis 5
NCT05544864Coronary Artery Disease, Restenoses, Coronary
Deutsches Herzzentrum Muenchen
Not applicable
376
Frankfurt am Main, Essen, Hamburg, Munich
2022-09-28
Active, closed
The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events
NCT05421286HIV-1-infection, Inflammation, AIDS
Rigshospitalet, Denmark
Observational
991
Bonn, Cologne, Eppendorf, Frankfurt am Main, Hamburg
2022-09-28
Recruiting
Efficacy of Luspatercept in ESA-naive LR-MDS Patients With or Without Ring Sideroblasts Who do Not Require Transfusions
NCT05384691Myelodysplastic Syndromes, Anemia
DrugLuspatercept
University of Leipzig
Phase 2
213
Berlin, Bonn, Cottbus, Erlangen, Greifswald, Hamburg, Kassel, Koblenz
2022-09-27
Recruiting
Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation
NCT05243797Multiple Myeloma
DrugsTeclistamab·Lenalidomide
European Myeloma Network B.V.
Phase 3
1,594
Hamburg, Heidelberg, Jena, Lübeck, München, Nuremberg, Tübingen, Würzburg
2022-09-08
Active, closed
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
NCT05425940Colorectal Cancer
DrugsZanzalintinib·Regorafenib·Tecentriq·Atezolizumab
Exelixis
Phase 3
901
Hanover, Dresden, Frankfurt am Main, Hamburg, München
2022-09-07
By invitation
Outcome of Patients With Severe Functional TR According to Medical, Transcatheter or Surgical Treatment
NCT05825898Tricuspid Regurgitation
Ottawa Heart Institute Research Corporation
Observational
3,500
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Leipzig, Mainz
2022-09-01
Active, closed
Study on an Investigational Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Administered as a 5- and/or 10-year Booster Doses in Children and Adolescents Vaccinated 5 or 10 Years Earlier as Toddlers
NCT04936685Meningococcal Immunisation, Healthy Volunteers
Sanofi Pasteur, a Sanofi Company
Phase 3
209
Bönnigheim, Bramsche, Bretten, Erfurt, Goch, Hamburg, Mönchengladbach, Schönau am Königssee
2022-08-23
Active, closed
Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
NCT05492578Dermatitis Atopic
DrugAmlitelimab
Sanofi
Phase 2/3
1,856
Augsburg, Bad Bentheim, Berlin, Blankenfelde-Mahlow, Dresden, Gera, Hamburg, Kiel
2022-08-22
Active, closed
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen
NCT05502341HIV-1-infection
DrugsBictegravir·Lenacapavir
Gilead Sciences
Phase 2/3
689
Berlin, Bonn, Frankfurt, Hamburg, München
2022-08-16
Recruiting
Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
NCT05254171Pancreatic Cancer Metastatic, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Stage IV
DrugsAbraxane·Nab-paclitaxel·Gemcitabine
Panbela Therapeutics, Inc.
Phase 2/3
600
Dresden, Berlin, Hamburg, Tübingen, Weiden
2022-08-08
Recruiting
A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation
NCT05410145KRAS P.G12C
DrugsD3S-001·Cetuximab·Pemetrexed·Cisplatin
D3 Bio (Wuxi) Co., Ltd
Phase 1/2
442
Cologne, Hamburg
2022-08-03
Recruiting
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
NCT05379595Advanced or Metastatic Colorectal Cancer
DrugsAmivantamab·Fluorouracil·Leucovorin·Irinotecan
Janssen Research & Development, LLC
Phase 1/2
225
Hamburg, Munich
2022-07-29
Active, closed
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
NCT05382286Triple Negative Breast Cancer, PD-L1 Positive
DrugsAbraxane·Sacituzumab Govitecan·Taxol·Nab-paclitaxel
Gilead Sciences
Phase 3
443
Berlin, Bonn, Bottrop, Cologne, Erlangen, Essen, Freiburg im Breisgau, Hamburg
2022-07-25
Active, closed
Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
NCT05382299Triple Negative Breast Cancer, PD-L1 Negative
DrugsAbraxane·Sacituzumab Govitecan·Nab-paclitaxel·Gemcitabine
Gilead Sciences
Phase 3
623
Berlin, Bonn, Cologne, Essen, Hamburg, Heidelberg, Lübeck, Mannheim
2022-07-20
Active, closed
STAR-LIFE: a Post-market Registry on MINIject
NCT05269680Open Angle Glaucoma
iSTAR Medical
Observational
320
Bochum, Düsseldorf, Hamburg, Kiel, Lübeck, Ulm
2022-07-20
Active, closed
Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat, Lenalidomide, and Dexamethasone in Participants With RRMM
NCT07150091Multiple Myeloma
DrugsNirogacestat·Belantamab mafodotin·Lenalidomide·Dexamethasone
GlaxoSmithKline
Phase 1/2
20
Hamburg
2022-07-19
Active, closed
A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer
NCT05217446Metastatic Colorectal Cancer
DrugsEncorafenib·Erbitux·Cetuximab·Keytruda
Pfizer
Phase 2
108
Munich, Hamburg
2022-07-11
Recruiting
Network Properties As Biomarkers for Non-Invasive Brain Stimulation (NIBS) After Stroke
NCT05560724Stroke, Ischemic
Universitätsklinikum Hamburg-Eppendorf
Not applicable
81
Hamburg
2022-07-01
Recruiting
A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C
NCT05163288Niemann-Pick Disease, Type C
DrugN-Acetyl-L-Leucine
IntraBio Inc
Phase 3
53
Giessen, Hamburg, Höchheim, München, Münster
2022-06-30
Active, closed
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
NCT05186753SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis
DrugBezuclastinib
Cogent Biosciences, Inc.
Phase 2
237
Aachen, Berlin, Hamburg, Kiel, Mannheim
2022-06-27
Active, closed
A Study to Assess the Safety and Immunogenicity of a COVID-19 Vaccine Booster in Healthy Adults
NCT05389319COVID-19
University Hospital Tuebingen
Phase 1
96
Tübingen, Hamburg
2022-06-24
Active, closed
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT04975997Multiple Myeloma
DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone
Celgene
Phase 3
939
Kiel, Frankfurt am Main, Hamburg, Heidelberg, Lübeck
2022-06-23
Active, closed
Study to Evaluate the Safety and Efficacy of Pegvaliase in Adolescents (Ages 12-17) With Phenylketonuria
NCT05270837Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Phase 3
55
Berlin, Hamburg, Mainz
2022-06-17
Recruiting
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
NCT05142189Non-Small Cell Lung Cancer
DrugsBNT116·Gotistobart·Cemiplimab·Osimertinib
BioNTech SE
Phase 1
320
Cologne, Frankfurt, Hamburg, Mainz
2022-06-17
Active, closed
Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome
NCT05382156Endogenous Cushing's Syndrome
DrugOsilodrostat
RECORDATI GROUP
Observational
206
Berlin, Cologne, Düsseldorf, Frankfurt, Hamburg, Munich, Oldenburg, Würzburg
2022-06-13
Active, closed
SIGNATURE Study : DCB (Legflow) vs POBA in Fempop Arteries
NCT04971772Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Angiopathy, Peripheral
Cardionovum GmbH
Observational
150
Berlin, Alsfeld, Hamburg, Heidelberg, Karlsruhe, Münster, Weinheim
2022-06-08
Recruiting
A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)
NCT05813678Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Observational
450
Cottbus, Hamburg, Leipzig, Mainz, Münster, Ulm
2022-06-06
Recruiting
A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB
NCT05183646FSGS
DrugRepagermanium
Dimerix Bioscience Pty Ltd
Phase 3
286
Aachen, Cologne, Dresden, Hamburg, Hanover, Lübeck, Mainz, Villingen-Schwenningen
2022-05-30
Active, closed
A Study of Talquetamab and Teclistamab Each in Combination With a Programmed Cell Death Receptor-1 (PD-1) Inhibitor for the Treatment of Participants With Relapsed or Refractory Multiple Myeloma
NCT05338775Relapsed/ Refractory Multiple Myeloma
DrugsTalquetamab·Teclistamab
Janssen Research & Development, LLC
Phase 1
74
Dresden, Hamburg, Heidelberg, Würzburg
2022-05-25
Active, closed
PASS of Paediatric Patients Initiating Selumetinib
NCT05388370Neurofibromatosis Type 1
AstraZeneca
Observational
124
Dresden, Duisburg, Hamburg, Hanover, München, Tübingen
2022-05-23
Active, closed
IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)
NCT05155254Metastatic Melanoma, Unresectable Melanoma
DrugsIO102-IO103·Pembrolizumab
IO Biotech
Phase 3
407
Augsburg, Berlin, Bochum, Erlangen, Essen, Frankfurt, Halle, Hamburg
2022-05-17
Recruiting
German Dementia Registry
NCT07433010Dementia Disorder
RWTH Aachen University
Observational
5,000
Heidelberg, Mannheim, Tübingen, Ulm, Erlangen, Frankfurt (Oder), Rüdersdorf, Hamburg
2022-05-16
Active, closed
Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
NCT05069558Stroke, Patent Foramen Ovale, PFO
Occlutech International AB
Not applicable
450
Hamburg, Frankfurt, Heidelberg, Lübeck
2022-05-09
Recruiting
WoO: Window of Opportunity Trial of Olaparib and Durvalumab in Histologically Proven EOC
NCT04644289Epithelial Ovarian Cancer
DrugsOlaparib·Durvalumab
AGO Research GmbH
Phase 2
60
Mannheim, München, Hamburg, Essen, Dresden, Berlin
2022-05-05
Recruiting
Clinical Trial With Donor Modified Immune Cells in Living Donor Kidney Transplantation
NCT05365672Kidney Transplantation
TolerogenixX GmbH
Phase 2
126
Berlin, Hamburg, Heidelberg, Munich, Münster, Stuttgart
2022-05-04
Active, closed
Adjuvant Encorafenib and Binimetinib in High-risk Stage II Melanoma With a BRAF Mutation.
NCT05270044Melanoma
Pierre Fabre Medicament
Phase 3
815
Heidelberg, Würzburg, Buxtehude, Dresden, Kiel, Hamburg
2022-05-02
Recruiting
PMCF Study on the Safety, Performance and Clinical Benefits Data of the Anatomical Shoulder Bipolar System
NCT05358574Revision of a Shoulder Prosthesis
Zimmer Biomet
Observational
40
Hamburg
2022-04-22
Active, closed
A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma
NCT05028348Multiple Myeloma
DrugsElotuzumab·Selinexor·Pomalidomide·Dexamethasone
European Myeloma Network B.V.
Phase 3
117
Chemnitz, Düsseldorf, Greifswald, Hamburg
2022-04-19
Recruiting
(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
NCT05208047Advanced Gastrointestinal Stromal Tumors, Metastatic Cancer
DrugsBezuclastinib·Sunitinib·Midazolam
Cogent Biosciences, Inc.
Phase 3
482
Bad Saarow, Berlin, Essen, Hamburg, Hanover, Mannheim
2022-04-14
Active, closed
Post-market Clinical Follow-up of the SRS Implant
NCT05170074Pelvic Organ Prolapse
pfm medical gmbh
Observational
175
Bensheim, Augsburg, Hagen, Hamburg, Kiel, Neustadt, Zittau
2022-04-07
Active, closed
A Phase 3 Study of Rusfertide in Patients With Polycythemia Vera
NCT05210790Polycythemia Vera
DrugRusfertide
Protagonist Therapeutics, Inc.
Phase 3
293
Aachen, Berlin, Dresden, Greifswald, Hamburg, Koblenz, Mainz
2022-04-01
Active, closed
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
NCT05196035Chronic Kidney Disease, Proteinuria
DrugFinerenone
Bayer
Phase 3
219
Heidelberg, Hanover, Bonn, Essen, Münster, Berlin, Hamburg
2022-03-28
Active, closed
Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC
NCT05301842Hepatocellular Carcinoma
DrugsTremelimumab·Lenvatinib·Durvalumab
AstraZeneca
Phase 3
760
Bonn, Chemnitz, Dresden, Düsseldorf, Frankfurt, Göttingen, Hamburg, Hanover
2022-03-28
By invitation
Resting-state Connectivity and Individual Differences in Affective Placebo Responsiveness
NCT07479966Condition: Healthy
Stefanie Brassen
Observational
50
Hamburg
2022-03-27
Recruiting
Clinical Assessment of Essential Remote Monitoring Functions in Pacemakers
NCT05165095Bradycardia, Remote Monitoring
MicroPort CRM
Observational
206
Hamburg, Pirna, Rostock
2022-03-25
Active, closed
Prostate Imaging Using MRI +/- Contrast Enhancement
NCT04571840Prostate Cancer
University College, London
Not applicable
500
Düsseldorf, Essen, Frankfurt, Hamburg
2022-03-22
Recruiting
Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis
NCT04804553Active Juvenile Psoriatic Arthritis
DrugApremilast
Amgen
Phase 3
60
Berlin, Dresden, Hamburg, Sankt Augustin
2022-03-17
Active, closed
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
NCT05132582HER2 Positive Breast Cancer
DrugsPerjeta·Tucatinib·Herceptin·Pertuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
654
Münster, Manheim, Mannheim, Augsburg, Berlin, Hamburg, München, Ulm
2022-03-07
Recruiting
Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglutide (HM15912) in SBS-IF Subjects
NCT04775706Short Bowel Syndrome
Hanmi Pharmaceutical Company Limited
Phase 2
18
Hamburg, Tübingen
2022-03-03
Active, closed
Fragility Fractures of the Pelvis (FFP)
NCT04182776Pelvic Fracture
AO Innovation Translation Center
Observational
420
Hamburg, Leipzig, Mainz
2022-03-01
Recruiting
Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting Diseases and Immunosuppression
NCT05688774Pneumonia, Sepsis, Shock, Septic
Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps
Observational
300
Berlin, Dessau, Hamburg, Leipzig, Marburg, Münster, Rotenburg (Wümme)
2022-02-28
Active, closed
Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)
NCT05051033Mitral Valve Regurgitation
Annetine Gelijns
Not applicable
450
Cologne, Bad Oeynhausen, Bad Nauheim, Bad Rothenfelde, Berlin, Frankfurt, Freiburg im Breisgau, Hamburg
2022-02-21
Active, closed
Clinical Impact of the IBox As an Early Intervention TooL
NCT05112315Kidney Diseases, Kidney Disease, Chronic, Kidney Transplant Rejection, Kidney Transplant; Complications
Predict4Health
Not applicable
507
Düsseldorf, Hamburg
2022-02-18
Active, closed
D,L-MEthadone and mFOLFOX6 in Treatment of Advanced Colorectal Cancer
NCT05212012Chemo-refractory Colorectal Carcinoma
AIO-Studien-gGmbH
Phase 1/2
11
Hamburg, Mutlangen, Ulm
2022-02-17
Active, closed
A Study of Nivolumab Plus Chemotherapy in First Line Treatment of Adult Participants With Advanced or Metastatic Gastric Cancer
NCT05165264Gastric Cancer
Bristol-Myers Squibb
Observational
600
Hamburg
2022-02-16
Active, closed
A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II (STARLIGHT)
NCT04573023Mucopolysaccharidosis II
DrugsIdursulfase·JR-141
JCR Pharmaceuticals Co., Ltd.
Phase 3
86
Giessen, Hamburg, Höchheim, Mainz
2022-02-14
Active, closed
Trial to Assess the Safety and Efficacy of Sirolimus-Coated Balloon vs. Uncoated Standard Angioplasty for the Treatment of Below-the-knee Peripheral Arterial Disease
NCT04772300Peripheral Artery Disease
Jena University Hospital
Not applicable
230
Tübingen, Hamburg, Bad Oeynhausen, Bad Krozingen, Brandenburg, Coburg, Flensburg, Heidelberg
2022-02-10
Recruiting
Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma
NCT04879043Multiple Myeloma, Plasma Cell Disorder
DrugHDP-101
Heidelberg Pharma AG
Phase 1/2
78
Berlin, Chemnitz, Cologne, Hamburg, Heidelberg, Kiel, Lübeck, Mainz
2022-02-07
Active, closed
Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN
NCT05309668Neurofibromatosis Type 1
DrugSelumetinib
AstraZeneca
Phase 1/2
36
Hamburg, München, Tübingen
2022-01-21
Active, closed
Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
NCT05407636AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
DrugsEylea·Aflibercept
AbbVie
Phase 3
735
Freiburg im Breisgau, Ulm, Bonn, Münster, Ludwigshafen am Rhein, Hamburg, Püttlingen
2022-01-13
Active, closed
A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy
NCT05139602Hidradenitis Suppurativa
DrugLutikizumab
AbbVie
Phase 2
210
Erlangen, Berlin, Bochum, Dessau, Hamburg
2021-12-28
Recruiting
Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia
NCT04925479Myeloid Leukemia, Philadelphia Positive
DrugABL001
Novartis Pharmaceuticals
Phase 1/2
34
Erlangen, Essen, Hamburg
2021-12-27
Active, closed
From the Emergency Department Directly to Ablation of Atrial Fibrillation Study
NCT05294445Atrial Fibrillation (AF)
Asklepios proresearch
Not applicable
350
Bad Nauheim, Berlin, Cologne, Düsseldorf, Frankfurt, Giessen, Hamburg, Hamburg-Nord
2021-12-15
By invitation
Long-Term Follow-Up Study After Gene-Modified Cell Treatment in Kite Studies
NCT05041309Solid and Hematological Malignancies, Autoimmune Diseases
DrugsKITE-197·SPRX002·KITE-753·Tecartus
Kite, A Gilead Company
Observational
1,500
Dresden, Hamburg, Heidelberg, Mainz, München, Würzburg
2021-12-15
Active, closed
Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
NCT04954859Hepatitis B
DrugBepirovirsen
GlaxoSmithKline
Phase 2
360
Düsseldorf, Berlin, Frankfurt am Main, Hamburg
2021-12-14
Recruiting
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
NCT05176483Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC), Urothelial Carcinoma (UC), Solid Tumor
DrugsZanzalintinib·Relatlimab·Yervoy·Opdivo
Exelixis
Phase 1
1,394
Essen, Hamburg, Heidelberg, Herne, Jena, München, Nürtingen, Trier
2021-12-14
Active, closed
BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)
NCT04982393Primary Hyperoxaluria Type 1
Alnylam Pharmaceuticals
Observational
207
Berlin, Cologne, Hamburg
2021-12-13
Active, closed
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)
NCT05156281Relapsing Multiple Sclerosis
DrugsTeriflunomide·Remibrutinib
Novartis Pharmaceuticals
Phase 3
1,007
Freiburg im Breisgau, Essen, Hamburg
2021-12-13
Active, closed
Prognostic Role of Circulating Tumor DNA in Resectable Pancreatic Cancer
NCT04246203Pancreas Cancer
Ludwig-Maximilians - University of Munich
Observational
200
Munich, Berlin, Cologne, Hamburg, Ulm
2021-12-12
Active, closed
EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke
NCT05029414Acute Ischemic Stroke
University Hospital, Basel, Switzerland
Not applicable
543
Aachen, Berlin, Bremen, Dresden, Erfurt, Frankfurt, Göttingen, Hamburg
2021-12-09
Recruiting
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis
Blueprint Medicines Corporation
Phase 2/3
534
Aachen, Berlin, Erlangen, Hamburg, Mannheim, Munich
2021-11-30
Active, closed
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
NCT04924608Neurofibromatosis 1, Plexiform Neurofibroma (PN)
DrugSelumetinib
AstraZeneca
Phase 3
145
Hamburg, Tübingen, Würzburg
2021-11-19
Recruiting
A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma
NCT05160584Relapsed/Refractory Multiple Myeloma
Janssen Pharmaceutica N.V., Belgium
Observational
300
Berin, Cologne, Dresden, Hamburg, Hamm, Heidelberg, Karlsruhe, Leipzig
2021-11-18
Active, closed
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
NCT04988295Carcinoma, Non-Small-Cell Lung
DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin
Janssen Research & Development, LLC
Phase 3
776
Berlin, Hamburg, Heidelberg, Heilbronn, Leipzig, Moers, München, Recklinghausen
2021-11-17
Active, closed
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT05089734Non-Small Cell Lung Cancer
DrugsSacituzumab Govitecan·Docetaxel
Gilead Sciences
Phase 3
603
Braunschweig, Esslingen am Neckar, Hamburg, Heilbronn, Immenhausen, Kassel, Lübeck, Mannheim
2021-11-17
Active, closed
Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable and Locally Advanced or Metastatic PRCC
NCT05043090Papillary Renal Cell Carcinoma
DrugsSavolitinib·Sunitinib·Durvalumab
AstraZeneca
Phase 3
148
Hamburg, Hanover, München, Ulm
2021-10-28
Active, closed
A Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab
NCT07280377Anal Cancer Metastatic, Squamous Cell Carcinoma of the Anus Stage Unspecified, Pancreatic Cancer Metastatic, Unresectable Pancreatic Carcinoma
DrugsGemcitabine and nab-paclitaxel·Pelareorep·Lonsurf·Trifluridine/Tipiracil
Oncolytics Biotech
Phase 1/2
122
Heidelberg, Heilbronn, Tübingen, Ulm, Augsburg, München, Hamburg, Frankfurt am Main
2021-10-27
Active, closed
Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
NCT05113251Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer
DrugsHerzuma·Perjeta·Herceptin·Adriamycin
AstraZeneca
Phase 3
927
Augsburg, Berlin, Erlangen, Hamburg, Heidelberg, Kiel, Leipzig, Mönchengladbach
2021-10-25
Recruiting
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
NCT04929223Metastatic Colorectal Cancer
DrugsDivarasib·Tiragolumab·Inavolisib·Folfiri
Hoffmann-La Roche
Phase 1
542
Berlin, Bochum, Dresden, Düsseldorf, Hamburg, Heilbronn, München, Ulm
2021-10-22
Active, closed
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
NCT05050942Gastro-enteropancreatic Neuroendocrine Tumor
DrugsCAM2029·Octreotide LAR
Camurus AB
Phase 3
332
Berlin, Erlangen, Essen, Hamburg, Heidelberg, Mannheim, Ulm
2021-10-22
Active, closed
Low-dose Atropine for Myopia Control in Children
NCT03865160Myopia, Progressive
DrugAtropine eye
University Eye Hospital, Freiburg
Phase 2/3
302
Ahaus, Bonn, Cologne, Erlangen, Essen, Freiburg im Breisgau, Göttingen, Hamburg
2021-10-19
Active, closed
A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
NCT05083169Multiple Myeloma
DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab
Janssen Research & Development, LLC
Phase 3
587
Dresden, Düsseldorf, Essen, Freiburg im Breisgau, Hamburg, Hamm, Heidelberg, Kiel
2021-10-14
Active, closed
Mirvetuximab Soravtansine (IMGN853), in Folate Receptor Alpha (FRα) High Recurrent Ovarian Cancer
NCT04274426Recurrent Epithelial Ovarian, Fallopian or Peritoneal Carcinoma
DrugsMirvetuximab Soravtansine·Pegylated liposomal doxorubicin·Gemcitabine·Paclitaxel
AGO Research GmbH
Phase 2
136
Berlin, Dessau, Dresden, Essen, Frankfurt, Hamburg, Hanover, Karlsruhe
2021-10-13
Active, closed
Observational GORE® VIABAHN® Endoprosthesis With PROPATEN Bioactive Surface Global Registry
NCT04907240Peripheral Artery Disease, Popliteal Aneurysm, Hemodialysis Access, Visceral Artery Aneurysms
W.L.Gore & Associates
Observational
614
Frankfurt, Hamburg, Heidelberg, Reinbek, Tübingen
2021-10-09
Active, closed
Study on an Investigational Yellow Fever Vaccine Compared With Stamaril in Adults in Europe and Asia
NCT05011123Yellow Fever
DrugYellow fever vaccine
Sanofi Pasteur, a Sanofi Company
Phase 2
690
Berlin, Hamburg, München, Rostock
2021-10-07
Active, closed
Plasma On Chronic Wounds for Epidermal Regeneration
NCT05855499Chronic Ulcer of Lower Extremity
Coldplasmatech
Not applicable
120
Tübingen, München, Regensburg, Hamburg, Bochum, Dresden, Berlin, Saalfeld
2021-10-01
Recruiting
Safe and Timely Antithrombotic Removal (STAR) Registry
NCT05077124Hemorrhage, Surgical, Hemorrhage Postoperative, Blood Loss, Surgical, Blood Loss, Postoperative
CytoSorbents, Inc
Observational
1,000
Coswig, Erlangen, Essen, Hamburg, Hanover, Heidelberg, Kiel, Leipzig
2021-09-30
Recruiting
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
NCT04973605Relapsed/Refractory Multiple Myeloma
DrugsSonrotoclax·Carfilzomib·Pomalidomide·Daratumumab
BeOne Medicines
Phase 1/2
246
Aachen, Dresden, Hamburg, Würzburg
2021-09-16
Active, closed
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
NCT04909801Rheumatoid Arthritis
DrugsAbatacept·Humira·Adalimumab·Methotrexate
Bristol-Myers Squibb
Phase 3
338
Berlin, Bonn, Freiburg im Breisgau, Hamburg, Planegg
2021-09-15
Recruiting
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444Bladder Carcinoma, Ureter Carcinoma, Renal Pelvis Carcinoma, Non-small Cell Lung Cancer
Guardant Health, Inc.
Observational
2,285
Hamburg, Heilbronn, Munich
2021-09-07
Active, closed
A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease
NCT04929210Arthritis, Psoriatic
DrugsTremfya·Guselkumab
Janssen Research & Development, LLC
Phase 4
411
Berlin, Hamburg, Herne, Ratingen
2021-08-30
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04961996Early Breast Cancer
DrugGiredestrant
Hoffmann-La Roche
Phase 3
4,170
Karlsruhe, Augsburg, Berlin, Chemnitz, Erlangen, Essen, Georgsmarienhütte, Hamburg
2021-08-27
Active, closed
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
NCT04923893Multiple Myeloma
DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine
Janssen Research & Development, LLC
Phase 3
743
Berlin, Dresden, Freiburg im Breisgau, Hamburg, Heidelberg, Leipzig, Mainz, München
2021-08-19
Active, closed
Efficacy and Safety of Carfilzomib in Combination With Ibrutinib vs Ibrutinib in Waldenström's Macroglobulinemia
NCT04263480Waldenstrom Macroglobulinemia
DrugsIbrutinib·Carfilzomib
Christian Buske
Phase 2
99
Berlin, Bremen, Dortmund, Dresden, Hamburg, Hanover, Landshut, Munich
2021-08-18
Recruiting
Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients
NCT04844866Diffuse Large B-cell Lymphoma
Miltenyi Biomedicine GmbH
Phase 2
213
Augsburg, Bochum, Cologne, Erlangen, Essen, Hamburg, Heidelberg, Leipzig
2021-08-18
By invitation
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
NCT04957719Acute Myocardial Infarction
Viatris Innovation GmbH
Phase 3
25,000
Bad Krozingen, Bad Oeynhausen, Berlin, Bonn, Cologne, Dortmund, Dresden, Hamburg
2021-08-14
Recruiting
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
NCT05003986Focal Segmental Glomerulosclerosis, Minimal Change Disease, Immunoglobulin A Nephropathy, IgA Vasculitis
DrugSparsentan
Travere Therapeutics, Inc.
Phase 2
67
Cologne, Hamburg, Heidelberg
2021-08-12
Recruiting
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618C3G
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
98
Cologne, Aachen, Erlangen, Essen, Hamburg, Hanover, Heidelberg, Mainz
2021-07-28
Active, closed
Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria
NCT04747613Paroxysmal Nocturnal Hemoglobinuria
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
208
Dresden, Aachen, Essen, Hamburg, Riesa, Ulm
2021-07-27
Recruiting
Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical
NCT05296889Spine Fracture, Degenerative Disc Disease, Spinal Instability, Spinal Tumor
Aesculap AG
Observational
200
Hamburg, Meppen, Dresden, Halle
2021-07-21
Recruiting
A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications
NCT04877288Renal Allograft Recipients
DrugsCyclosporine A·Belatacept·Mycophenolate Mofetil·Tacrolimus
Bristol-Myers Squibb
Phase 3
102
Essen, Cologne, Hamburg, Heidelberg
2021-07-21
Recruiting
The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial
NCT04284839Bleeding Post Cardiac Surgery, Indication for Anticoagulation
DrugsDOAC·Dabigatran·Edoxaban·Warfarin
Population Health Research Institute
Phase 3
3,500
Leipzig, Jena, Bonn, Essen, Hamburg
2021-07-18
Active, closed
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment
NCT04908189Psoriatic Arthritis
DrugsApremilast·Deucravacitinib
Bristol-Myers Squibb
Phase 3
729
Ratingen, Cologne, Erlangen, Hamburg, Magdeburg, Minden, Tübingen
2021-07-15
Active, closed
A Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Velodrome)
NCT04657289Neovascular Age-related Macular Degeneration (nAMD)
DrugRanibizumab
Hoffmann-La Roche
Phase 3
451
Bonn, Cologne, Cottbus, Freiburg im Breisgau, Hamburg, Ludwigshafen, München, Münster
2021-07-14
Active, closed
Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.
NCT05018286Short Bowel Syndrome
DrugApraglutide
VectivBio AG
Phase 3
158
Berlin, Bonn, Hamburg, Heidelberg, Münster
2021-07-13
Active, closed
Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation
NCT04788888Symptomatic Severe Aortic Stenosis
Abbott Medical Devices
Not applicable
434
Bad Nauheim, Berlin, Dortmund, Dresden, Frankfurt, Hamburg, Leipzig, München
2021-07-13
Active, closed
A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Active Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE)
NCT04857034Lupus Erythematosus, Discoid, Lupus Erythematosus, Subacute Cutaneous
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 2
74
Dresden, Berlin, Erlangen, Hamburg
2021-07-12
Recruiting
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
European Foundation for Study of Chronic Liver Failure
Observational
3,000
Regensburg, Kiel, Aachen, Berlin, Frankfurt, Hamburg, Hanover, Heidelberg
2021-07-08
Active, closed
Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction
NCT04844931ST Elevation Myocardial Infarction
Helios Health Institute GmbH
Not applicable
250
Bremen, Dresden, Düsseldorf, Essen, Hamburg, Leipzig, Ludwigshafen, Lübeck
2021-07-05
Active, closed
Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).
NCT04895722Colorectal Cancer
DrugsPembrolizumab/Vibostolimab·MK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab
Merck Sharp & Dohme LLC
Phase 2
302
Munich, Marburg, Essen, Dresden, Magdeburg, Berlin, Hamburg
2021-06-25
Active, closed
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
NCT04793958Advanced Colorectal Cancer, Metastatic Colorectal Cancer
DrugsAdagrasib·Erbitux·MFOLFOX6·Folfiri
Mirati Therapeutics Inc.
Phase 3
461
Amberg, Berlin, Bochum, Dresden, Frankfurt am Main, Hamburg, Herne, Mönchengladbach
2021-06-24
Active, closed
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
NCT04739761Breast Cancer
DrugTrastuzumab deruxtecan
AstraZeneca
Phase 3
506
Berlin, Dresden, Erlangen, Essen, Frankfurt, Hamburg, Hanover, Kiel
2021-06-22
Active, closed
A Study of Guselkumab in Participants With Active Psoriatic Arthritis
NCT04882098Arthritis, Psoriatic
DrugGuselkumab
Janssen Research & Development, LLC
Phase 3
1,054
Berlin, Hamburg, Herne, Magdeburg, Mainz, Ratingen
2021-06-17
Recruiting
Multi-Gyn ActiGel Plus for Treatment of Bacterial Vaginosis
NCT04807842Bacterial Vaginoses
BioClin BV
Not applicable
200
Hamburg
2021-06-11
Recruiting
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
NCT04498767Gynecologic Cancer, Skin Cancer, Head and Neck Cancer, Sarcoma
European Organisation for Research and Treatment of Cancer - EORTC
Not applicable
200
Hamburg
2021-06-10
Recruiting
Lymph Node Mapping Via Flourescent Dye in Colon Cancer
NCT04959604Colon Carcinoma, Lymph Node Metastases
Universitätsklinikum Hamburg-Eppendorf
Not applicable
30
Hamburg
2021-05-31
Active, closed
Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)
NCT04704934Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
DrugsRamucirumab·Trastuzumab deruxtecan·Paclitaxel
Daiichi Sankyo
Phase 3
490
Berlin, Dresden Sachsen, Essen, Frankfurt Am Main Hessen, Hamburg, Kln Nordrhein-westfalen, Leipzig
2021-05-21
Active, closed
A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.
NCT04835805Melanoma
DrugsBelvarafenib·Cobimetinib·Nivolumab
Genentech, Inc.
Phase 1
65
Berlin, Hamburg, Mannheim, Tübingen, Würzburg
2021-05-13
Active, closed
Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation
NCT04818502Mitral Valve Regurgitation
Abbott Medical Devices
Observational
200
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Kiel, Leipzig
2021-05-04
Active, closed
ABLATE Versus PACE: PVI or AV Node Ablation and PM Implantation for Elderly Patients With Persistent AF
NCT04906668Atrial Fibrillation
St. Josefs-Hospital Wiesbaden GmbH
Not applicable
196
Bad Nauheim, Berlin, Essen, Frankfurt, Fürth, Hagen, Hamburg, Kaiserslautern
2021-05-01
Recruiting
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
NCT04752774Spasticity
DrugsDysport·Corabotase
Ipsen
Phase 1/2
240
Bonn, Düsseldorf, Goettigen, Hamburg, Mainz, Munich, Troisdorf, Tübingen
2021-04-29
Active, closed
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
NCT04784715Breast Cancer; HER2-positive; Metastatic
DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab
AstraZeneca
Phase 3
1,157
Berlin, Dresden, Erlangen, Essen, Frankfurt am Main, Freiburg im Breisgau, Hamburg, Heidelberg
2021-04-26
Recruiting
Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial
NCT04448028Liver Cirrhosis
DrugEsomeprazole
Universitätsklinikum Hamburg-Eppendorf
Phase 4
476
Hamburg
2021-04-22
Active, closed
DiamondTemp Global Registry
NCT04735016Arrhythmia
Medtronic Cardiac Ablation Solutions
Observational
545
Bad Oeynhausen, Hamburg, Paderborn
2021-04-22
Active, closed
Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum
NCT04589650PIK3CA-related Overgrowth Spectrum (PROS)
DrugAlpelisib
Novartis Pharmaceuticals
Phase 2
206
Freiburg im Breisgau, Düsseldorf, Leipzig, Hamburg, Heidelberg
2021-04-19
Recruiting
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
NCT04663750Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
King's College Hospital NHS Trust
Phase 3
210
Bonn, Hamburg, Ludwigshafen, München, Münster, Sulzbach, Ulm, Würzburg
2021-04-16
Recruiting
Tendyne European Experience Registry
NCT04898335Mitral Regurgitation
LMU Klinikum
Observational
400
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Leipzig, Mainz
2021-04-15
Active, closed
Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion
NCT04794699Solid Tumor
DrugsIDE397·Sacituzumab Govitecan
IDEAYA Biosciences
Phase 1
169
Hamburg
2021-04-14
Active, closed
A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura
NCT04683003Thrombotic Thrombocytopenic Purpura (TTP)
DrugTAK-755
Takeda
Phase 3
77
Hamburg, Jena
2021-04-14
Active, closed
A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis
NCT04527380Juvenile Psoriatic Arthritis, Enthesitis Related Arthritis
DrugsIxekizumab·Adalimumab
Eli Lilly and Company
Phase 3
101
Freiburg im Breisgau, Sankt Augustin, Sendenhorst, Berlin, Bremen, Hamburg
2021-04-13
Active, closed
Validation of the POGO Score for Classification of Videolaryngoscopy in Children - Post-hoc Analysis of the PeDiAC Study
NCT07115407Intubation, Pediatric, Intubation; Difficult or Failed, Airway Management, Airway Complication of Anesthesia
Universitätsklinikum Hamburg-Eppendorf
Observational
809
Hamburg
2021-04-12
Active, closed
Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
DrugsPelabresib·Ruxolitinib
Novartis Pharmaceuticals
Phase 3
430
Ulm, Augsburg, Halle, Jena, Hamburg
2021-04-09
Active, closed
Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
NCT04662255Lymphoma, Mantle-Cell
DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib
Loxo Oncology, Inc.
Phase 3
500
Ulm, Würzburg, Giessen, Münster, Koblenz, Mainz, Lübeck, Hamburg
2021-04-08
Active, closed
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Moderate to Severe Upper Facial Lines
NCT04821089Moderate to Severe Upper Facial Lines
DrugsDysport·Corabotase
Ipsen
Phase 1/2
727
Kassel, Berlin, Darmstadt, Düsseldorf, Hamburg, Mahlow
2021-04-06
Recruiting
A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Children and Adolescent Participants With Moderate to Severe Plaque Psoriasis
NCT04772079Plaque Psoriasis
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
153
Münster, Mainz, Dresden, Berlin, Hamburg
2021-03-23
Recruiting
Clinical Cohort Study - TRUST
NCT05521451Arrhythmias, Cardiac, Atrial Fibrillation, Atrial Flutter, Ventricular Tachycardia
Universitätsklinikum Hamburg-Eppendorf
Observational
5,000
Hamburg
2021-03-17
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
DrugAutogene cevumeran
BioNTech SE
Phase 2
327
Berlin, Bochum, Bonn, Frankfurt am Main, Halle, Hamburg, Hanover, Heidelberg
2021-03-08
Recruiting
Hamburg TranscathEteR Mitral Valve REplacement RegiStry
NCT04914468Mitral Valve Disease
Universitätsklinikum Hamburg-Eppendorf
Observational
300
Hamburg
2021-03-08
Active, closed
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
313
Aachen, Baden-Warttemberg, Düsseldorf, Halle, Hamburg, Jena, Leipzig, Mannheim
2021-02-25
Recruiting
An Observational Post-marketing Study Using Commercially Approved Biosense Webster (BWI) Medical Devices for the Treatment of Participants With Cardiac Arrhythmias
NCT04750798Arrhythmias, Cardiac
Biosense Webster, Inc.
Observational
8,000
Bad Neustadt an der Saale, Bad Oeynhausen, Bad Segeberg, Bautzen, Essen, Frankfurt, Giessen, Hamburg
2021-02-22
Recruiting
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
NCT04545502Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
Vascutek Ltd.
Observational
2,000
Berlin, Bonn, Freiburg im Breisgau, Hamburg, Leipzig, Mainz, Munich
2021-02-17
Active, closed
Immunogenicity, Safety, Reactogenicity and Persistence of an Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above
NCT04732871Respiratory Syncytial Virus Infections
GlaxoSmithKline
Phase 3
1,720
Essen, Goch, Hamburg, Mainz, München, Wallerfing, Würzburg
2021-02-15
Active, closed
SUCCESS (SelUtion, Safety, effiCaCy, hEalth economicS and promS) PTA Study
NCT04776434Peripheral Artery Disease
M.A. Med Alliance S.A.
Not applicable
723
Arnsberg, Bad Krozingen, Buchholz, Essen, Flensburg, Hamburg, Heidelberg, Langensteinbach
2021-02-08
Active, closed
MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb
NCT04649359Multiple Myeloma
DrugElranatamab
Pfizer
Phase 2
187
Hamburg
2021-02-02
Recruiting
SCAD : a Registry of Spontaneous Coronary Artery Dissection
NCT06601270Spontaneous Coronary Artery Dissection
European Society of Cardiology
Observational
1,500
Bad Rothenfelde, Berlin, Hamburg, Stuttgart
2021-01-30
Active, closed
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
NCT04624659Sickle Cell Disease
DrugEtavopivat
Forma Therapeutics, Inc.
Phase 3
450
Berlin, Frankfurt am Main, Freiburg im Breisgau, Hamburg, Heidelberg, Regensburg
2021-01-29
Recruiting
Prospective Registry and Biobank for Long-term Observational Studies in Adult Patients with Pulmonary Hypertension
NCT04654650Pulmonary Hypertension
Universitätsklinikum Hamburg-Eppendorf
Observational
5,000
Hamburg
2021-01-26
Active, closed
BIOMIGA: Results From Magnetic Resonance Imaging
NCT06633484Migraine
Universitätsklinikum Hamburg-Eppendorf
Observational
219
Hamburg
2021-01-15
Active, closed
Bioavailability and Practicability of Envarsus Versus Advagraf in Liver Transplant Recipients
NCT04720326Prophylaxis Against Liver Transplant Rejection
DrugsTacrolimus Pill·Envarsus·Tacrolimus
Edward Geissler
Phase 4
268
Aachen, Berlin, Essen, Frankfurt, Hamburg, Hanover, Heidelberg, Jena
2020-12-23
Recruiting
Ablation of Consecutive Atrial Tachycardia
NCT05239364Heart Arrhythmia, Heart Diseases, Arrhythmias, Cardiac, Atrial Tachycardia
Evangelical Hospital Düsseldorf
Not applicable
100
Hamburg, Düsseldorf, Berlin, Hagen, Karlsruhe, Kiel
2020-12-22
Active, closed
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
NCT04607421Neoplasms
DrugsZirabev·Encorafenib·Erbitux·Xeloda
Pfizer
Phase 3
841
Munich, Frankfurt am Main, Hanover, Leipzig, Berlin, Charlottenburg, Dresden, Hamburg
2020-12-21
Active, closed
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT04652882Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
DrugTasimelteon
Vanda Pharmaceuticals
Phase 3
70
Berlin, Hamburg, Marburg, Schwerin
2020-12-09
Active, closed
Assessment of the Axone Micro Quadripolar Lead for Enhanced Cardiac Resynchronization Therapy
NCT04463641Heart Failure, Cardiac Resynchronization Therapy
MicroPort CRM
Not applicable
92
Hamburg, Heidelberg, Kiel
2020-12-03
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (acelERA Breast Cancer)
NCT04576455Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Fulvestrant
Hoffmann-La Roche
Phase 2
303
Aschaffenburg, Berlin, Hamburg, Paderborn, Stralsund
2020-11-27
Active, closed
Restoration of Central Vision With the PRIMA System in Patients With Atrophic AMD
NCT04676854Geographic Atrophy
Science Corporation
Not applicable
38
Aachen, Bonn, Hamburg, Ludwigshafen am Rhein, Lübeck, Munich, Münster, Sulzbach
2020-11-24
Active, closed
Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
NCT04592913Gastrointestinal Neoplasms, Esophagogastric Junction
DrugDurvalumab
AstraZeneca
Phase 3
957
Berlin, Dresden, Frankfurt, Hamburg, Heidelberg, Heilbronn, Jena, Mainz Am Rhein
2020-11-17
Recruiting
Vyxeos® With Clofarabine for Pediatric AML
NCT07156435Relapsed Pediatric AML, Refractory Pediatric AML
DrugClofarabine
Princess Maxima Center for Pediatric Oncology
Phase 1
25
Augsburg, Berlin, Essen, Frankfurt, Hamburg
2020-11-06
Recruiting
LANDMARK Trial: a Randomised Controlled Trial of Myval THV
NCT04275726Aortic Valve Stenosis
Meril Life Sciences Pvt. Ltd.
Not applicable
988
Bad Nauheim, Leipzig, Bad Krozingen, Braunschweig, Dresden, Hamburg, Regensburg
2020-11-04
Active, closed
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)
NCT04512235AL Amyloidosis
DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)
Alexion Pharmaceuticals, Inc.
Phase 3
281
Berlin, Düsseldorf, Essen, Hamburg, Heidelberg, Würzburg
2020-11-03
Recruiting
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
NCT04688190Mitral Regurgitation, Mitral Valve Disease, Mitral Annular Calcification
Universitätsklinikum Hamburg-Eppendorf
Observational
1,000
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Lübeck, Mainz
2020-11-01
Recruiting
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor
DrugsRezatapopt·Keytruda·Pembrolizumab
PMV Pharmaceuticals, Inc
Phase 1/2
300
Heidelberg, Augsburg, Hamburg, Frankfurt am Main, Essen
2020-10-29
Recruiting
The AFteR Registry - Follow-up Study to Monitor the Efficacy and Safety of the Occlutech AFR in Heart Failure Patients
NCT04405583Heart Failure
Occlutech International AB
Observational
150
Bottrop, Coburg, Cologne, Erfurt, Hamburg, Heide, Jena, Osnabrück
2020-10-28
Active, closed
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
NCT04446117Metastatic Prostate Cancer, Prostate Adenocarcinoma
DrugsZytiga·Xtandi·Abiraterone·Abiraterone acetate
Exelixis
Phase 3
575
Nürtingen, Duisburg, Gütersloh, Münster, Lübeck, Berlin, Hamburg, Hanover
2020-10-19
Active, closed
CHAMPION-AF Clinical Trial
NCT04394546Atrial Fibrillation, Stroke, Bleeding
DrugsNon-Vitamin K Anticoagulant·NOAC
Boston Scientific Corporation
Not applicable
3,000
Berlin, Coburg, Dresden, Erfurt, Essen, Frankfurt, Hamburg, Lübeck
2020-10-15
Active, closed
IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
NCT04221815Atherosclerosis
Medstar Health Research Institute
Not applicable
3,100
Bad Oeynhausen, Cologne, Bad Segeberg, Dachau, Hamburg, Neuss, Rostock
2020-10-14
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Palbociclib·Letrozole
Hoffmann-La Roche
Phase 3
992
Berlin, Chemnitz, Dresden, Essen, Georgsmarienhütte, Göttingen, Hamburg, Hanover
2020-10-09
Active, closed
Isa-KRd vs KRd in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL)
NCT04483739Multiple Myeloma
European Myeloma Network B.V.
Phase 3
302
Freiburg im Breisgau, Hamburg, München
2020-09-25
Active, closed
A Clinical Study of the Safety and Effectiveness of an Investigational Cell Therapy Given With and Without an Investigational RNA-based Vaccine in Patients With Organ Tumors
NCT04503278Solid Tumor
BioNTech Cell & Gene Therapies GmbH
Phase 1
214
Berlin, Cologne, Erlangen, Hamburg, Hanover, Heidelberg, Mainz, Regensburg
2020-09-16
Active, closed
AFAMOSI: Efficacy and Safety of Afatinib Followed by Osimertinib Compared to Osimertinib in Patients with EGFRmutated/T790M Mutation Negative Nonsquamous NSCLC
NCT04413201Non-squamous NSCLC
DrugsAfatinib·Osimertinib
Michael Hopp
Phase 4
34
München, Giessen, Offenbach, Berlin, Bremen, Hamburg, Hamm, Immenstadt im Allgäu
2020-09-11
Active, closed
BGP+ Stent as Bridging Stent in BEVAR
NCT03982940Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture
Marc Bosiers, MD
Not applicable
118
Heidelberg, Kiel, Aachen, Hamburg, Leipzig, Munich, Münster, Nuremberg
2020-09-09
Recruiting
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
NCT04848844Congenital Heart Disease, Heart Failure, Transplant; Complication, Failure, Arrythmia
Universitätsklinikum Hamburg-Eppendorf
Observational
2,000
Hamburg
2020-09-02
Active, closed
Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
NCT04468984Myelofibrosis (MF)
DrugsNavitoclax·Ruxolitinib
AbbVie
Phase 3
330
Mannheim, Mutlangen, Augsburg, Rostock, Bochum, Chemnitz, Dresden, Hamburg
2020-08-31
Active, closed
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)
NCT04504825AL Amyloidosis
DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)
Alexion Pharmaceuticals, Inc.
Phase 3
125
Berlin, Düsseldorf, Essen, Hamburg, Heidelberg, Würzburg
2020-08-25
Active, closed
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
NCT04493853Hormone-Sensitive Prostate Cancer
DrugsZytiga·Capivasertib·Abiraterone acetate
AstraZeneca
Phase 3
1,012
Berlin, Duisburg, Hamburg, Herne, Mettmann, Münster, Nuremberg, Nürtingen
2020-07-13
Recruiting
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
NCT04307576Leukemia, Acute Lymphoblastic
DrugsInotuzumab Ozogamicin·Imatinib·Blinatumomab
Mats Heyman
Phase 3
6,430
Bielefeld, Bonn, Bremen, Hamburg, Krefeld, Mainz
2020-07-13
Recruiting
Safety and Early Signs of Efficacy of IL12-L19L19.
NCT04471987Advanced Solid Tumor, Metastatic Solid Tumor
Philogen S.p.A.
Phase 1
80
Hamburg, Heidelberg, Leipzig, Tübingen
2020-07-01
Active, closed
SAPIEN 3 Ultra System PMCF
NCT04555967Aortic Valve Stenosis
Edwards Lifesciences
Observational
200
Berlin, Hamburg
2020-06-30
Recruiting
Efficacy and Safety of the CG-100 Intraluminal Bypass Device
NCT04184973Rectal Cancer, Rectal Tumor, Rectal/Anal
Colospan Ltd.
Not applicable
250
Hamburg
2020-06-23
Active, closed
Episealer® Knee System IDE Clinical Study
NCT04000659Degenerative Lesion of Articular Cartilage of Knee
Episurf Medical Inc.
Not applicable
13
Berlin, Hamburg
2020-06-18
Active, closed
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
NCT04270409Plasma Cell Myeloma
DrugsMontelukast·Diphenhydramine·Acetaminophen·Isatuximab
Sanofi
Phase 3
337
Hamburg, Heidelberg
2020-06-16
Active, closed
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
NCT04181827Multiple Myeloma
DrugsCilta-cel·Pomalidomide·Bortezomib·Daratumumab
Janssen Research & Development, LLC
Phase 3
419
Cologne, Dresden, Hamburg, Leipzig, Tübingen, Würzburg
2020-06-12
Active, closed
Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System
NCT04201132Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis
Contego Medical, Inc.
Not applicable
305
Bad Krozingen, Berlin, Frankfurt, Hamburg, Leipzig, Radebeul
2020-06-12
Active, closed
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
NCT04379596Gastric Cancer
DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Fluorouracil
AstraZeneca
Phase 2
452
Frankfurt, Hamburg, Leipzig, Mannheim, München
2020-06-03
Recruiting
Tricuspid RegUrgitaTion Hamburg Cohort
NCT04755842Tricuspid Regurgitation
Universitätsklinikum Hamburg-Eppendorf
Observational
2,000
Hamburg
2020-06-01
Active, closed
Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease
NCT04291261Acute-graft-versus-host Disease
DrugUvadex
Universitätsklinikum Hamburg-Eppendorf
Phase 2
24
Hamburg, Erlangen, Regensburg
2020-05-18
Active, closed
Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer
NCT04305496Locally Advanced (Inoperable) or Metastatic Breast Cancer
DrugsCapivasertib·Fulvestrant
AstraZeneca
Phase 3
818
Dresden, Erlangen, Essen, Frankfurt, Gelsenkirchen, Hamburg, Hanover, Heidelberg
2020-04-16
Recruiting
Natural History and Longitudinal Clinical Assessments in NCL / Batten Disease, the International DEM-CHILD Database
NCT04613089Neuronal Ceroid Lipofuscinosis, Batten Disease, CLN1 Disease, CLN2 Disease
Universitätsklinikum Hamburg-Eppendorf
Observational
500
Hamburg
2020-04-08
Active, closed
Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)
NCT04199689Papillomavirus Infections
DrugNonavalent HPV vaccine
Merck Sharp & Dohme LLC
Phase 3
6,033
Frankfurt am Main, Berlin, Hamburg
2020-02-27
Active, closed
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
NCT04195750Carcinoma, Renal Cell
DrugsBelzutifan·Everolimus
Merck Sharp & Dohme LLC
Phase 3
755
Tübingen, Düsseldorf, Essen, Dresden, Magdeburg, Jena, Berlin, Hamburg
2020-02-27
Active, closed
A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma
NCT04108195Multiple Myeloma
DrugsDarzalex·Talquetamab·Teclistamab·Pomalidomide
Janssen Research & Development, LLC
Phase 1
290
Freiburg im Breisgau, Hamburg, Heidelberg, Würzburg
2020-02-21
Active, closed
A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer
NCT04211337Medullary Thyroid Cancer
DrugsVandetanib·Selpercatinib·Cabozantinib
Loxo Oncology, Inc.
Phase 3
291
München, Würzburg, Hanover, Essen, Mainz, Magdeburg, Berlin, Hamburg
2020-02-11
Recruiting
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
NCT05999994Neoplasms, Child, Adolescent
DrugsRamucirumab·Vinorelbine·Abemaciclib·Temozolomide
Eli Lilly and Company
Phase 2
105
Essen, Freiburg im Breisgau, Hamburg
2020-01-22
Active, closed
Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)
NCT04164901Grade 2 Glioma, Residual Glioma, Recurrent Glioma
DrugVorasidenib
Institut de Recherches Internationales Servier
Phase 3
331
Essen, Hamburg, Heidelberg, Mannheim
2020-01-05
Active, closed
Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia
NCT04150887Leukemia, Myeloid, Acute
DrugsCusatuzumab·Venclexta·Azacitidine·Venetoclax
OncoVerity, Inc.
Phase 1
61
Hamburg, Leipzig, München
2019-12-23
Recruiting
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis
NCT03969329Secondary Hyperparathyroidism
DrugEtelcalcetide
Amgen
Phase 3
24
Bonn, Cologne, Hamburg, Hanover, Heidelberg
2019-12-20
Active, closed
Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma
NCT04091126Multiple Myeloma
DrugsBelantamab mafodotin·Bortezomib·Lenalidomide·Dexamethasone
GlaxoSmithKline
Phase 1
118
Dresden, Hamburg, Schwerin, Tübingen
2019-12-18
Recruiting
Additional Left Atrial Appendage Isolation During Balloon Ablation for Persistent or Long-standing Persistent Atrial Fibrillation
NCT04240366Persistent or Long-standing Persistent Atrial Fibrillation
University of Luebeck
Not applicable
350
Hamburg, Lübeck
2019-12-17
Active, closed
Prophylactic Reinforcement of Ventral Abdominal Incisions Trial
NCT03911700Open Midline Laparotomy
C. R. Bard
Not applicable
477
Hamburg, Berlin, Heidelberg, Koblenz
2019-12-12
Recruiting
Medtronic Cardiac Surgery PMCF Registry
NCT04073420Valve Disease, Heart
Medtronic Cardiac Surgery
Observational
2,700
Bad Rothenfelde, Dresden, Düsseldorf, Hamburg, Leipzig, München
2019-12-02
Active, closed
Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Feladilimab (GSK3359609) in Participants With RRMM
NCT07217119Multiple Myeloma
DrugsFeladilimab·Belantamab mafodotin
GlaxoSmithKline
Phase 1/2
25
Hamburg
2019-11-26
Recruiting
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
Abbott Medical Devices
Observational
1,000
Tübingen, Düsseldorf, Münster, Mainz, Homburg, Hamburg
2019-11-26
Active, closed
Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance
NCT04150068HIV-1-infection
DrugLenacapavir
Gilead Sciences
Phase 2/3
72
Frankfurt am Main, Essen, Hamburg
2019-11-21
Active, closed
Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia
NCT04232241Acute Myeloid Leukemia in Remission, Acute Lymphoblastic Leukemia in Remission, Myelodysplastic Syndromes
Universitätsklinikum Hamburg-Eppendorf
Phase 2
167
Düsseldorf, Essen, Frankfurt, Freiburg im Breisgau, Hamburg, Hanover, Leipzig, Münster
2019-11-14
Recruiting
APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study
NCT05119842Paralysis, Unilateral, Vocal Cord
APrevent Biotech GmbH
Not applicable
30
Gera, Hamburg
2019-11-13
Active, closed
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma
NCT04133636Multiple Myeloma
DrugsCilta-cel·Bortezomib·Daratumumab·Lenalidomide
Janssen Research & Development, LLC
Phase 2
208
Hamburg, Würzburg
2019-11-07
Recruiting
A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation
NCT04065399Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia
DrugsCobicistat·Revumenib
Syndax Pharmaceuticals
Phase 1/2
447
Ulm, Essen, Greifswald, Gutenberg, Hamburg, Leipzig, Nuremberg
2019-11-05
Active, closed
Pediatric Long-Term Follow-up and Rollover Study
NCT03975829Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood
DrugsDabrafenib·Trametinib
Novartis Pharmaceuticals
Phase 4
163
Cologne, Augsburg, Berlin, Essen, Hamburg
2019-11-04
Recruiting
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
NCT03944876Cluster Headache
DrugsBotox·Botulinum toxin type A
Norwegian University of Science and Technology
Phase 3
112
Hamburg
2019-11-01
Active, closed
Orbital Fractures Registry
NCT03887988Orbital Fractures, Blow Out Fracture of Orbit
AO Innovation Translation Center
Observational
300
Hamburg, Munich
2019-11-01
Active, closed
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
NCT04157348Eosinophilic Granulomatous Vasculitis
DrugsBenralizumab·Mepolizumab
AstraZeneca
Phase 3
140
Bamberg, Freiburg im Breisgau, Hamburg, Kirchheim, Lübeck
2019-10-29
Active, closed
A Study of Baricitinib (LY3009104) in Participants From 2 Years to Less Than 18 Years Old With Active JIA-Associated Uveitis or Chronic Anterior Antinuclear Antibody-Positive Uveitis
NCT04088409Uveitis
DrugsBaricitinib·Adalimumab
Eli Lilly and Company
Phase 3
30
Sankt Augustin, Berlin, Hamburg
2019-10-16
Recruiting
Early Prostate Cancer Recurrence With PSMA PET Positive Unilateral Pelvic Lesion(s)
NCT04271579Prostate Cancer
Martini-Klinik am UKE GmbH
Not applicable
397
Hamburg
2019-10-15
Active, closed
Role of Lymphnode Dissection in Men With Prostate Cancer Treated With Radical Prostatectomy
NCT04269512Prostate Cancer
Martini-Klinik am UKE GmbH
Not applicable
3,650
Hamburg
2019-10-15
Active, closed
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
NCT04050436Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
DrugsVusolimogene Oderparepvec·Cemiplimab
Replimune, Inc.
Phase 2
231
Berlin, Essen, Hamburg, Heidelberg, München, Tübingen
2019-10-08
Active, closed
Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
NCT04126200Multiple Myeloma
DrugsFeladilimab·Nirogacestat·Belantamab mafodotin·Isatuximab
GlaxoSmithKline
Phase 1/2
208
Frankfurt, Hamburg, Kiel, Leipzig
2019-10-07
Recruiting
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
NCT03955445C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
225
Erlangen, Essen, Hamburg, Heidelberg, Mainz
2019-10-03
Active, closed
A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
NCT03989414Multiple Myeloma
DrugsElotuzumab·Mezigdomide·Isatuximab·Carfilzomib
Celgene
Phase 1/2
424
Freiburg im Breisgau, Hamburg, Heidelberg, München, Würzburg
2019-09-30
By invitation
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
NCT03683186PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension
United Therapeutics
Phase 3
1,000
Heidelberg, Greifswald, Mainz, Homburg, Leipzig, Donaueschingen, Dresden, Hamburg
2019-09-23
Recruiting
The Global Cardiovascular Risk Consortium
NCT05466825All-cause Mortality, Cardiovascular Disease
Universitätsklinikum Hamburg-Eppendorf
Observational
3,000,000
Hamburg
2019-09-20
Active, closed
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
NCT03992404Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
DrugXeomin
Merz Pharmaceuticals GmbH
Phase 3
603
Aachen, Berlin, Bonn, Düsseldorf, Hamburg, Wiesbaden, Würzburg
2019-09-16
Recruiting
Hamburg AoRtic Valve cOhoRt
NCT04227002Aortic Valve Stenosis
Universitätsklinikum Hamburg-Eppendorf
Observational
15,000
Hamburg
2019-09-01
Active, closed
A Post-market Clinical Follow up of the Genio® System for the Treatment of Obstructive Sleep Apnea in Adults
NCT04031040Obstructive Sleep Apnea
Nyxoah S.A.
Not applicable
110
Hamburg, Jena, Mannheim, München, Wuppertal
2019-09-01
Recruiting
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
NCT04064060Myelodysplastic Syndromes (MDS), Beta-thalassemia, Myeloproliferative Neoplasm(MPN)-Associated Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
665
Berlin, Dresden, Düsseldorf, Halle, Hamburg, Hanover, Leipzig, Mainz
2019-08-12
Active, closed
A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)
NCT04008030Metastatic Colorectal Cancer
DrugsFluorouracil·Leucovorin·Ipilimumab·Irinotecan
Bristol-Myers Squibb
Phase 3
839
Dresden, Essen, Hamburg, Hanover, Heidelberg, Marburg, Munich
2019-08-05
Active, closed
Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma
NCT03937843Seminoma, Testicular Cancer
DrugsEtoposide·Cisplatin·Carboplatin
Swiss Cancer Institute
Phase 2
135
München, Berlin, Essen, Hamburg, Ludwigsburg, Tübingen, Ulm
2019-07-29
Active, closed
Evaluation of Safety and Efficacy of the Accero® (Heal) Stent for Intracranial Aneurysm Treatment
NCT03957382Intracranial Aneurysm
Acandis GmbH
Observational
130
Hamburg, Berlin, Meppen, Recklinghausen
2019-07-23
Active, closed
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis
NCT03725007Juvenile Idiopathic Arthritis (JIA)
DrugUpadacitinib
AbbVie
Phase 1
124
Sankt Augustin, Sendenhorst, Bad Bramstedt, Berlin, Hamburg
2019-06-24
Active, closed
A Study of TNB-383B in Participants With Relapsed or Refractory Multiple Myeloma
NCT03933735Multiple Myeloma
AbbVie
Phase 1/2
220
Cologne, Münster, Dresden, Hamburg
2019-06-24
Active, closed
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
NCT03767244Prostatic Neoplasms
DrugApalutamide
Janssen Research & Development, LLC
Phase 3
2,517
Aachen, Braunschweig, Cologne, Eisleben Lutherstadt, Essen, Frankfurt am Main, Gronau, Hamburg
2019-06-11
Recruiting
Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk
NCT04029363Mitral Regurgitation
HighLife SAS
Not applicable
120
Bad Krozingen, Bonn, Dresden, Hamburg, Heidelberg, Leipzig, Munich, Rostock
2019-05-28
Recruiting
Transgender In Transition
NCT04028219Gender Incongruence
Universitätsklinikum Hamburg-Eppendorf
Observational
750
Frankfurt am Main, Hamburg, Munich
2019-05-15
Recruiting
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
NCT03686124Refractory Cancer, Recurrent Cancer, Solid Tumor, Adult, Cancer
DrugsAnzu-cel·Opdivo·Nivolumab
Immatics US, Inc.
Phase 1/2
375
Heidelberg, Munich, Würzburg, Bonn, Mainz, Dresden, Berlin, Hamburg
2019-05-14
Active, closed
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561Diabetes Mellitus, Type 2
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,500
Friedrichsthal, Hamburg, Münster, Rehlingen-Siersburg, Saint Ingbert-Oberwürzbach
2019-05-08
Active, closed
(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT03731260Indolent Systemic Mastocytosis
DrugAvapritinib
Blueprint Medicines Corporation
Phase 2
251
Aachen, Berlin, Hamburg, Lübeck, Mainz, Mannheim, Munich
2019-04-16
Recruiting
A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis
NCT03773965Juvenile Idiopathic Arthritis
DrugBaricitinib
Eli Lilly and Company
Phase 3
190
Berlin, Hamburg, Heidelberg, Sankt Augustin, Tübingen
2019-04-05
Active, closed
Data-driven Development of a Core Dataset for Difficult Airway Alerts
NCT07275567Airway Management, Intubation; Difficult or Failed, Airway Complication of Anesthesia
Universitätsklinikum Hamburg-Eppendorf
Observational
1,785
Hamburg
2019-04-01
Active, closed
Automatic PredICtion of Edema After Stroke
NCT04057690Stroke, Acute, Brain Edema
University Hospital Tuebingen
Observational
1,687
Berlin, Bonn, Bremen, Düsseldorf, Hamburg, Hanover, Heidelberg, Leipzig
2019-04-01
Active, closed
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy
NCT03675308Psoriatic Arthritis
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
964
Herne, Buch, Frankfurt, Hamburg
2019-03-25
Active, closed
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
NCT03845166Neoplasm Malignant, Renal Cell Carcinoma, Hormone Receptor Positive Breast Carcinoma, Metastatic Castration-resistant Prostate Cancer
DrugsZanzalintinib·Avelumab·Tecentriq·Atezolizumab
Exelixis
Phase 1
325
Nürtingen, Münster, Hamburg
2019-03-20
Recruiting
Characterisation of phenotYpes in aCute Heart faiLure patiEnts
NCT07508891Acute Heart Failure, Decompensated Heart Failure, Cardiogenic Shock
Universitätsklinikum Hamburg-Eppendorf
Observational
1,000
Hamburg
2019-03-01
Active, closed
Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa
NCT03827798Hidradenitis Suppurativa
DrugsArumakimig·Ianalumab·Remibrutinib
Novartis Pharmaceuticals
Phase 2
248
Bochum, Frankfurt, Hamburg, Schwerin
2019-02-27
Active, closed
NVT ALLEGRA TAVI System TF in Failing Calcified Aortic Heart Valves in a Real-world Patient Population
NCT03613246Transcatheter Aortic Valve Implantation
NVT GmbH
Observational
346
Bad Bevensen, Bad Rothenfelde, Hamburg, Hanover, Heilbronn
2019-02-20
Active, closed
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
NCT03682536Myelodysplastic Syndromes
DrugsEpoetin Alfa·Luspatercept
Celgene
Phase 3
363
Baden-Warttemberg, Berlin, Cologne, Dresden, Duisburg, Düsseldorf, Hamburg, Keil
2019-01-02
Active, closed
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
NCT03706833Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Edwards Lifesciences
Not applicable
1,247
Bad Oeynhausen, Cologne, Dresden, Essen, Giessen, Hamburg, Heidelberg, Leipzig
2018-11-30
Active, closed
Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)
NCT03707743Aortic Dissection
IRCCS San Raffaele
Observational
200
Nuremberg, Hamburg, Münster
2018-10-30
Active, closed
A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
NCT03539744Multiple Myeloma
DrugsPomalidomide·Venetoclax·Dexamethasone
AbbVie
Phase 3
265
Stuttgart, Tübingen, Würzburg, Chemnitz, Kiel, Jena, Berlin, Hamburg
2018-10-22
Active, closed
A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
NCT03602859Ovarian Neoplasms, Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
DrugsNiraparib·Dostarlimab
Tesaro, Inc.
Phase 3
1,400
Berlin, Hamburg, Kiel, Münster, Ravensburg, Wolfsburg
2018-10-11
Recruiting
Extension Study for the Port Delivery System With Ranibizumab (Portal)
NCT03683251Neovascular Age-Related Macular Degeneration
DrugPDS Implant with Ranibizumab
Hoffmann-La Roche
Phase 3
1,000
Bonn, Cologne, Cottbus, Freiburg im Breisgau, Hamburg, Ludwigshafen, München, Münster
2018-09-20
Active, closed
Reducing Lung CongestIon Symptoms in Advanced Heart Failure
NCT03499236Heart Failure
V-Wave Ltd
Not applicable
605
Berlin, Hamburg, Leipzig, München, Remscheid, Rostock
2018-09-19
Active, closed
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
NCT03547973Metastatic Urothelial Cancer
DrugsDomvanalimab·Zimberelimab·Avelumab·Enfortumab Vedotin
Gilead Sciences
Phase 2
502
Duisburg, Frankfurt, Freiburg im Breisgau, Hamburg, Heidelberg, Herne, Jena, Koblenz
2018-08-13
Recruiting
A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)
NCT02991469Juvenile Idiopathic Arthritis
DrugSarilumab
Sanofi
Phase 2
51
Berlin, Hamburg, Sankt Augustin, Sendenhorst
2018-08-09
Active, closed
A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
NCT03568318Atopic Dermatitis
DrugUpadacitinib
AbbVie
Phase 3
1,533
Heidelberg, Frankfurt am Main, Münster, Selters, Kiel, Bonn, Hamburg, Hanover
2018-08-09
Recruiting
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
NCT03435796Neoplasms
Celgene
Phase 2/3
1,541
Berlin, Cologne, Dresden, Düsseldorf, Essen, Frankfurt, Hamburg, Heidelberg
2018-07-19
Active, closed
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
NCT03519945Ulcerative Colitis
DrugMirikizumab
Eli Lilly and Company
Phase 3
1,058
Berlin, Brandenburg, Halle, Hamburg, Hanover, Ludwigshafen
2018-07-18
Active, closed
Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy
NCT03755791Hepatocellular Carcinoma
DrugsSorafenib·Cabozantinib·Tecentriq·Atezolizumab
Exelixis
Phase 3
837
Frankfurt am Main, Kassel, Berlin, Hamburg
2018-06-10
Active, closed
International Validation Study of Sentinel Node Biopsy in Early Cervical Cancer
NCT03386734Cervical Cancer
Centre Hospitalier Universitaire de Besancon
Not applicable
989
Berlin, Dresden, Düsseldorf, Essen, Fürth, Giessen, Hamburg, Hanover
2018-05-03
Recruiting
CEDUR - German IBD Registry
NCT07319442Ulcerative Colitis (UC), Indeterminate Colitis, Crohn Disease (CD)
ImmunoRegister gUG
Observational
10,000
Hamburg
2018-05-03
Active, closed
THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study
NCT02732704Aortic Regurgitation
JenaValve Technology, Inc.
Not applicable
100
Bad Nauheim, Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg
2018-04-20
Active, closed
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
NCT03466411Crohn's Disease
DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3·Ustekinumab
Janssen Research & Development, LLC
Phase 2/3
1,409
Augsburg, Berlin, Dresden, Frankfurt, Frankfurt am Main, Hamburg, Hanover, Heidelberg
2018-04-13
Active, closed
Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow
NCT03363373Neuroblastoma
DrugsNaxitamab·Gm-Csf
Y-mAbs Therapeutics
Phase 2
122
Hamburg, Mainz, Regensburg
2018-04-03
Active, closed
To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.
NCT03330847Metastatic Triple Negative Breast Cancer
DrugCeralasertib
AstraZeneca
Phase 2
273
Dresden, Frankfurt am Main, Hamburg, Hanover, Leipzig, München, Witten
2018-03-07
Recruiting
Dabrafenib and/or Trametinib Rollover Study
NCT03340506Melanoma, Non Small Cell Lung Cancer, Solid Tumor, Rare Cancers
DrugsDabrafenib·Trametinib
Novartis Pharmaceuticals
Phase 4
100
Mannheim, Augsburg, Berlin, Essen, Hamburg, Heidelberg
2018-01-26
Active, closed
Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients
NCT02922036Heart Failure
EBR Systems, Inc.
Not applicable
300
Bernau, Erlangen, Hamburg
2018-01-17
Active, closed
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
NCT03395197mCRPC
Pfizer
Phase 3
1,054
Düsseldorf, Hamburg, Heidelberg, Kirchheim, Münster, Nürtingen
2017-12-18
Active, closed
Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)
NCT03301506Primary Biliary Cirrhosis
DrugSeladelpar
Gilead Sciences
Phase 3
340
Berlin, Erlangen, Hamburg, Herne, Kiel, Tübingen
2017-12-12
Active, closed
Study Assessing The "Best of" Radiotherapy vs the "Best of" Surgery in Patients With Oropharyngeal Carcinoma
NCT02984410Oropharyngeal Cancer, Supraglottic Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma
European Organisation for Research and Treatment of Cancer - EORTC
Not applicable
112
Cologne, Halle, Hamburg, Jena, Leipzig, München, Tübingen, Ulm
2017-11-27
Active, closed
Efficacy, Safety and Tolerability Study of Long-acting Cabotegravir Plus Long-acting Rilpivirine (CAB LA + RPV LA) in Human-immunodeficiency Virus-1 (HIV-1) Infected Adults
NCT03299049HIV Infections
DrugsRilpivirine·Cabotegravir
ViiV Healthcare
Phase 3
1,049
Berlin, Bonn, Essen, Frankfurt, Hamburg, Hanover, München
2017-10-27
Recruiting
Givinostat in Duchenne's Muscular Dystrophy Long-term Safety and Tolerability Study
NCT03373968Duchenne Muscular Dystrophy
DrugHydroxyurea
Italfarmaco
Phase 2/3
206
Essen, Hamburg, München
2017-10-24
Active, closed
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair
NCT02912559Colon Adenocarcinoma, DNA Repair Disorder, Lynch Syndrome, Stage III Colon Cancer AJCC v8
DrugsLederfolin·Leucovorin Calcium·Tecentriq·Fluorouracil
National Cancer Institute (NCI)
Phase 3
712
Dresden, Berlin, Bochum, Cologne, Esslingen am Neckar, Hamburg, Leipzig, Mannheim
2017-10-16
Active, closed
Anatomical Shoulder Domelock System Study
NCT03312465Avascular Necrosis, Revision Surgery, Conditions Consequent to Earlier Operations, Arthritis, Rheumatoid
Zimmer Biomet
Observational
73
Daun, Hamburg
2017-09-28
Recruiting
SafeTy and Outcome of contemPorary Treatment Strategies for Cardiogenic SHOCK
NCT03313687Cardiogenic Shock
Universitätsklinikum Hamburg-Eppendorf
Observational
2,500
Hamburg
2017-09-01
Recruiting
Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases
NCT04706234Multiple System Atrophy, Parkinson Disease, Progressive Supranuclear Palsy, Motor Neuron Disease
Kliniken Beelitz GmbH
Observational
350
Ulm, Beelitz-Heilstätten, Hanover, Münster, Dresden, Stadtroda, Hamburg
2017-09-01
Active, closed
Feasibility and Safety of IMP321 (Eftilagimod Alpha) for Advanced Stage Solid Tumors
NCT03252938Solid Tumors, Peritoneal Carcinomatosis, NSCLC Adenocarcinoma, Urothelial Carcinoma
DrugsEfti·Avelumab
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 1
83
Bad Saarow, Cologne, Essen, Frankfurt, Giessen, Hamburg, Herne, Mainz
2017-08-15
Active, closed
Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone
NCT03104842Multiple Myeloma
DrugsIsatuximab·Carfilzomib·Lenalidomide·Dexamethasone
Universitätsklinikum Hamburg-Eppendorf
Phase 2
246
Berlin, Bielefeld, Bonn, Chemnitz, Cologne, Eschweiler, Essen, Hamburg
2017-08-15
Active, closed
Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
NCT03007147Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia, T Acute Lymphoblastic Leukemia
DrugsL-leucovorin·Isophosphamide·Therapeutic Hydrocortisone·Levofolinate
Children's Oncology Group
Phase 3
352
Kiel, Hamburg
2017-08-08
Active, closed
The OCTOBER Trial - European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction (OCTOBER)
NCT03171311Ischaemic Heart Disease, Ischemic Heart Disease
Aarhus University Hospital Skejby
Not applicable
1,201
Berlin, Hamburg, Kiel
2017-07-05
Active, closed
Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
NCT03164616Non Small Cell Lung Cancer NSCLC
DrugsTremelimumab·Abraxane·Durvalumab·Pemetrexed
AstraZeneca
Phase 3
1,186
Berlin, Essen, Freiburg im Breisgau, Gauting, Hamburg, Heidelberg, Immenhausen, Mainz
2017-06-01
Active, closed
REDUCE LAP-HF TRIAL II
NCT03088033Heart Failure
Corvia Medical
Not applicable
608
Bad Nauheim, Berlin, Düsseldorf, Freiburg im Breisgau, Göttingen, Hamburg, Heidelberg, Leipzig
2017-06-01
Active, closed
Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality
NCT03112980Aortic Valve Stenosis
Universitätsklinikum Hamburg-Eppendorf
Not applicable
1,414
Hamburg, Aachen, Bad Krozingen, Bad Nauheim, Bad Neustadt an der Saale, Bad Oeynhausen, Berlin, Bernau
2017-05-10
Active, closed
Enhancing Recovery in Early Schizophrenia
NCT02926859Schizophrenia
Central Institute of Mental Health, Mannheim
Phase 2
180
Mannheim, Munich, Berlin, Aachen, Cologne, Hamburg
2017-04-08
Active, closed
Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)
NCT03043872Small Cell Lung Carcinoma Extensive Disease
DrugsTremelimumab·Etoposide·Durvalumab·Cisplatin
AstraZeneca
Phase 3
987
Aachen, Berlin, Gauting, Gera, Hamburg, Heidelberg, Mainz, Regensburg
2017-03-27
Active, closed
Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer
NCT03036098Urothelial Cancer
DrugsYervoy·Opdivo·Ipilimumab·Nivolumab
Bristol-Myers Squibb
Phase 3
1,314
Dresden, Essen, Freiburg im Breisgau, Hamburg, Hanover, Jena, Mannheim, Nuremberg
2017-03-24
Active, closed
Prospective Registry for Patients Undergoing Surgery for Male Stress Urinary Incontinence
NCT02757274Urinary Incontinence, Stress
European Association of Urology Research Foundation
Observational
1,054
Hamburg, Mainz, Münster
2017-02-22
Active, closed
A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy
NCT02993523Acute Myeloid Leukemia (AML)
DrugsAzacitidine·Venetoclax
AbbVie
Phase 3
443
Ulm, Frankfurt am Main, Münster, Halle, Hamburg, Hanover
2017-02-02
Active, closed
Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET Patients
NCT03049189Neuroendocrine Tumors
Drugs177Lu-DOTATOC·Everolimus
ITM Solucin GmbH
Phase 3
324
Bad Berka, Berlin, Bonn, Erlangen, Essen, Hamburg, Magdeburg, Marburg
2017-02-02
Recruiting
CArdioSurgEry Atrial Fibrillation Register
NCT03091452Atrial Fibrillation
Stiftung Institut fuer Herzinfarktforschung
Observational
2,000
München, Hamburg, Bad Rothenfelde
2017-01
Active, closed
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
NCT02960022Prostate Cancer
DrugsLeuprolide Acetate·Xtandi·Abiraterone acetate·Enzalutamide
Astellas Pharma Global Development, Inc.
Phase 2
900
Nürtingen, Waldshut-Tiengen, Mannheim, Duisburg, Bonn, Hamburg
2016-12-22
Active, closed
Ruxolitinib vs Allogeneic SCT for Patients With Myelofibrosis According to Donor Availability
NCT03333187Bone Marrow Fibrosis
DrugJakavi
Universitätsklinikum Hamburg-Eppendorf
Phase 2
87
Aachen, Berlin, Bonn, Düsseldorf, Halle, Hamburg, Jena, Mainz
2016-12-21
Active, closed
An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
NCT02808780Ulcerative Colitis
Janssen Biotech, Inc.
Observational
535
Berlin, Dessau Roblau, Halle, Hamburg, Heidelberg, Kiel, Leipzig, Ludwigshafen
2016-12-16
Recruiting
BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction
NCT02880618Heart Failure
CVRx, Inc.
Observational
500
Hamburg, Bad Oeynhausen, Berlin, Bernau, Chemnitz, Cologne, Detmold, Dresden
2016-12-13
Recruiting
Fosfomycin I.v. for Treatment of Severely Infected Patients
NCT02979951Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
Infectopharm Arzneimittel GmbH
Observational
1,000
Berlin, Braunschweig, Düsseldorf, Frankfurt, Hamburg, Jena, Kiel, Lübeck
2016-12
Recruiting
Neurovascular Product Surveillance Registry
NCT02988128Intracranial Aneurysm, Stroke, Ischemic
Medtronic Neurovascular Clinical Affairs
Observational
4,000
Augsburg, Berlin, Bochum, Erfurt, Erlangen, Essen, Freiburg im Breisgau, Hamburg
2016-12
Active, closed
Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults
NCT02951052Infection, Human Immunodeficiency Virus, HIV Infections
Drugs2 NRTIs·Cabotegravir (CAB)·Rilpivirine (RPV)·Rilpivirine
ViiV Healthcare
Phase 3
618
Berlin, Bonn, Essen, Frankfurt, Hamburg, Hanover, München
2016-10-28
Active, closed
Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants
NCT02938520HIV Infections
DrugsCabotegravir (CAB)·Rilpivirine (RPV)·Rilpivirine·Cabotegravir
ViiV Healthcare
Phase 3
631
Berlin, Bonn, Essen, Frankfurt, Hamburg, Hanover, München
2016-10-27
Active, closed
A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
NCT02773030Multiple Myeloma
DrugsDarzalex·Iberdomide·Velcade·Carfilzomib
Celgene
Phase 1/2
466
Dresden, Düsseldorf, Hamburg, Heidelberg, Tübingen, Würzburg
2016-10-14
Active, closed
A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer
NCT02747004Metastatic Breast Cancer
DrugsTamoxifen·Abemaciclib
Eli Lilly and Company
Phase 2
234
Ulm, Hamburg
2016-09-14
Active, closed
Trial on Radical Upfront Surgery in Advanced Ovarian Cancer
NCT02828618Ovarian Cancer
AGO Study Group
Not applicable
797
Berlin, Dresden, Düsseldorf, Essen, Hamburg, München, Tübingen
2016-07
Active, closed
A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer
NCT02711553Biliary Tract Cancer, Metastatic Cancer, Advanced Cancer
DrugsRamucirumab·Gemcitabine·Cisplatin
Eli Lilly and Company
Phase 2
309
Tübingen, Ulm, Erlangen, Hanover, Berlin, Hamburg
2016-05-19
Recruiting
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
NCT02735707Community-acquired Pneumonia, Influenza, COVID-19
DrugsConvalescent plasma·Repagermanium·Ivermectin·Telmisartan
UMC Utrecht
Phase 3
20,000
Berlin, Cologne, Cottbus, Dortmund, Essen, Frankfurt, Hamburg, Jena
2016-04-11
Recruiting
Vercise™ DBS Dystonia Prospective Study
NCT02686125Dystonia
Boston Scientific Corporation
Observational
300
Berlin, Cologne, Düsseldorf, Freiburg im Breisgau, Hamburg, Hamm, Hanover, Kiel
2016-03-07
Active, closed
REDUCER-I: An Observational Study of the Neovasc Reducer™ System
NCT02710435Angina Pectoris, Angina Pectoris, Stable, Chronic Stable Angina
Shockwave Medical, Inc.
Observational
400
Bad Nauheim, Dresden, Essen, Freiburg im Breisgau, Giessen, Hamburg
2016-03
Recruiting
Hamburg City Health Study - a German Cohort Study
NCT03934957Coronary Heart Disease, Stroke, Dementia, Cancer
Universitätsklinikum Hamburg-Eppendorf
Observational
45,000
Hamburg
2016-02-08
Active, closed
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
NCT02629159Rheumatoid Arthritis
DrugsHumira·Adalimumab·Upadacitinib
AbbVie
Phase 3
1,629
Cologne, Herne, Rendsburg, Chemnitz, Hamburg, Munich
2015-12-01
Active, closed
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
NCT02489318Prostate Cancer
DrugApalutamide
Aragon Pharmaceuticals, Inc.
Phase 3
1,052
Bonn, Braunschweig, Eisleben Lutherstadt, Hamburg, Hanover, Leipzig, Lübeck, Nürtingen
2015-11-27
Recruiting
CAR-T Long Term Follow Up (LTFU) Study
NCT02445222Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program
Novartis Pharmaceuticals
Phase 3
1,400
Munich, Regensburg, Würzburg, Frankfurt am Main, Cologne, Leipzig, Berlin, Hamburg
2015-11-02
Active, closed
Study to Assess the Long-term Safety of Dupilumab Administered in Participants ≥6 Months to <18 Years of Age With Atopic Dermatitis (AD)
NCT02612454Atopic Dermatitis
DrugDupilumab
Regeneron Pharmaceuticals
Phase 3
880
Tübingen, Frankfurt am Main, Münster, Dresden, Gera, Hamburg, Munich, München
2015-10-15
Active, closed
The Ruxo-BEAT Trial in Patients With High-risk Polycythemia Vera or High-risk Essential Thrombocythemia
NCT02577926Polycythemia Vera (PV), Essential Thrombocythemia (ET)
DrugsJakavi·Ruxolitinib
RWTH Aachen University
Phase 2
207
Mannheim, Ulm, Winnenden, Aschaffenburg, Müchen, Nuremberg, Hamburg, Mainz
2015-10
Active, closed
Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS)
NCT02215265Human Papillomavirus (HPV)-Positive Oropharyngeal Cancer
DrugCisplatin
Lisette Nixon
Phase 3
1,269
Berlin, Giessen, Hamburg, Homburg, Leipzig, Potsdam, Solingen, Ulm
2015-10
Active, closed
Post Market Clinical Follow Up of LEGION™ Primary TKS With VERILAST™
NCT02380092Degenerative Joint Disease
Smith & Nephew, Inc.
Observational
163
Langen, Hamburg, Saarbrücken-Dudweiler, Straubing
2015-09
Active, closed
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
NCT02375204Germ Cell Tumor, Teratoma, Choriocarcinoma, Germinoma
DrugsPegylated G-CSF·Ifosfamide·G-Csf·CDDP
Alliance for Clinical Trials in Oncology
Phase 3
420
Dresden, Berlin, Düsseldorf, Essen, Hamburg, Heidelberg, Koblenz, Marburg
2015-08-06
Active, closed
Phase III Open Label First Line Therapy Study of MEDI 4736 (Durvalumab) With or Without Tremelimumab Versus SOC in Non Small-Cell Lung Cancer (NSCLC)
NCT02453282Non-Small-Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
1,118
Aachen, Bad Berka, Berlin, Freiburg im Breisgau, Gauting, Hamburg, Heidelberg, Hemer
2015-07-21
Active, closed
Micra Transcatheter Pacing System Post-Approval Registry
NCT02536118Bradycardia
Medtronic
Observational
3,100
Aachen, Berlin, Cologne, Dresden, Düsseldorf, Frankfurt, Hamburg, Hanover
2015-07
Recruiting
An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma
NCT02265770Childhood Ependymoma
DrugsValproate·CDDP·Vincristine·Methotrexate
Centre Leon Berard
Phase 2/3
536
Hamburg
2015-06-02
Recruiting
German Stroke Registry - Endovascular Treatment
NCT03356392Acute Ischemic Stroke
Universitätsklinikum Hamburg-Eppendorf
Observational
10,000
Hamburg
2015-06
Active, closed
Impact of Radical Prostatectomy as Primary Treatment in Patients With Prostate Cancer With Limited Bone Metastases
NCT02454543Prostate Cancer
Martini-Klinik am UKE GmbH
Not applicable
452
Hamburg
2015-05
Active, closed
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
NCT02365597Urothelial Cancer
DrugsErdafitinib·Midazolam·Metformin
Janssen Research & Development, LLC
Phase 2
239
Berlin, Erlangen, Essen, Freiburg im Breisgau, Göttingen, Greifswald, Hamburg, Hanover
2015-04-22
Active, closed
CINC424A2X01B Rollover Protocol
NCT02386800Primary Myelofibrosis, Polycythemia Vera, Graft Versus Host Disease, Acute Myeloid Leukemia
DrugsJakavi·Ruxolitinib
Novartis Pharmaceuticals
Phase 4
279
Dresden, Jena, Aachen, Hamburg, Magdeburg, Mainz, Ulm
2015-03-05
Active, closed
A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial
NCT02320435Solid Tumors
DrugsPerjeta·Pertuzumab·Trastuzumab
Hoffmann-La Roche
Phase 3
154
Frankfurt am Main, Freiburg im Breisgau, Hamburg, Leer, Neumarkt
2015-02-02
Active, closed
A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)
NCT02912949Solid Tumours Harboring NRG1 Fusion, NSCLC Harboring NRG1 Fusion, Pancreatic Cancer Harboring NRG1 Fusion, NRG1 Fusion
DrugBispecific
Partner Therapeutics, Inc.
Phase 2
250
Hamburg, Heidelberg
2015-01
Active, closed
An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)
NCT02257736Prostatic Neoplasms
DrugsZytiga·Apalutamide·Abiraterone acetate·Prednisone
Aragon Pharmaceuticals, Inc.
Phase 3
982
Berlin, Dresden, Freiburg im Breisgau, Hamburg, Heidelberg, Münster, Nürtingen, Wuppertal
2014-11-26
Active, closed
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
NCT02246621Breast Cancer
DrugsAnastrozole·Abemaciclib·Letrozole
Eli Lilly and Company
Phase 3
493
Ludwigsburg, Ulm, München, Wiesbaden, Düsseldorf, Lübeck, Hamburg
2014-11-06
Active, closed
A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer
NCT02152631Non Small Cell Lung Cancer
DrugsErlotinib·Abemaciclib
Eli Lilly and Company
Phase 3
453
Berlin, Gera, Großhansdorf, Hamburg, Hanover, Heidelberg, Immenhausen, Nuremberg
2014-10-03
Active, closed
A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer
NCT02107703Breast Neoplasms
DrugsAbemaciclib·Fulvestrant
Eli Lilly and Company
Phase 3
669
Ludwigsburg, Tübingen, Augsburg, München, Hamburg
2014-07-22
Active, closed
Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer
NCT02170090Cholangiocarcinoma, Gall Bladder Carcinoma
DrugsCapecitabine·Gemcitabine·Cisplatin
Universitätsklinikum Hamburg-Eppendorf
Phase 3
789
Hamburg, Aachen, Berlin, Dresden, Essen, Esslingen am Neckar, Frankfurt, Freiburg im Breisgau
2014-04
Recruiting
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
NCT02071134Parkinson's Disease
Boston Scientific Corporation
Observational
1,500
Berlin, Cologne, Düsseldorf, Freiburg im Breisgau, Hamburg, Hamm, Kiel, Mainz
2014-03-04
Recruiting
Biomarkers in Acute Cardiac Care
NCT02355457Acute Coronary Syndrome, Myocardial Infarction, Chest Pain
Universitätsklinikum Hamburg-Eppendorf
Observational
5,000
Hamburg
2013-07
Recruiting
Cohort Study for Atrial Fibrillation Risk Stratification
NCT05442970Atrial Fibrillation
Universitätsklinikum Hamburg-Eppendorf
Observational
3,000
Hamburg
2013-06
Active, closed
Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma
NCT01843374Unresectable Pleural or Peritoneal Malignant Mesothelioma
DrugTremelimumab
MedImmune LLC
Phase 2
571
Berlin, Esslingen a.N., Freiburg im Breisgau, Gauting, Großhansdorf, Hamburg, Hemer, Karlsruhe
2013-05-17
Active, closed
An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis
NCT01357668Juvenile Idiopathic Arthritis
Bristol-Myers Squibb
Observational
800
Bad Bramstedt, Berlin, Freiburg im Breisgau, Hamburg, Heidelberg
2013-01-30
By invitation
Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease
NCT02040714Legg Calve Perthes Disease
Texas Scottish Rite Hospital for Children
Observational
1,500
Hamburg, Lübeck
2012-08
Active, closed
Neural Cardiac Therapy for Heart Failure Study (NECTAR-HF)
NCT01385176Heart Failure, Congestive Heart Failure
Boston Scientific Corporation
Not applicable
118
Bernau bei Berlin, Göttingen, Hamburg, Leipzig
2011-09-21
Recruiting
PRINCE Study - Cohort Study of Healthy Pregnant Women Followed by the Assessment of Children´s Health and Immunity
NCT05002023Pregnancy, Immune System Disorder
Universitätsklinikum Hamburg-Eppendorf
Observational
1,000
Hamburg
2011-02-02
Recruiting
International (Pediatric) Peritoneal Biobank
NCT01893710Kidney Failure, Chronic, Peritoneal Dialysis Complication, Transplantation, Healthy
Heidelberg University
Observational
500
Heidelberg, Berlin, Cologne, Essen, Hamburg, Marburg
2011-02-01
Recruiting
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
NCT02701036Late Onset Sporadic Cerebellar Ataxia
Ataxia Study Group
Observational
300
Berlin, Bonn, Essen, Frankfurt, Hamburg, Magdeburg, München, Rostock
2010-04
Active, closed
Study to Compare the Efficacy and Safety of Olaparib When Given in Combination With Carboplatin and Paclitaxel, Compared With Carboplatin and Paclitaxel in Patients With Advanced Ovarian Cancer
NCT01081951Ovarian Cancer
DrugsTaxol·Olaparib·Paclitaxel·Carboplatin
AstraZeneca
Phase 2
162
Essen, Frankfurt, Hamburg, München, Solingen
2010-02-04
Recruiting
Assessment of Transcatheter Edge-to-Edge Repair in Atrial Functional Mitral Regurgitation (ATRIAL-MR)
NCT06911099Atrial Functional Mitral Regurgitation, Mitral Insufficiency
University Hospital of Cologne
Observational
1,000
Munich, Cologne, Bad Oeynhausen, Bonn, Düsseldorf, Hamburg, Kiel, Leipzig
2010-01-01
Recruiting
PsoBest - The German Psoriasis Registry
NCT01848028Psoriasis, Psoriatic-arthritis
Universitätsklinikum Hamburg-Eppendorf
Observational
3,500
Hamburg
2008-01
Recruiting
Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)
NCT01257269Thrombotic Thrombocytopenic Purpura, Congenital Thrombotic Thrombocytopenic Purpura, Familial Thrombotic Thrombocytopenic Purpura, Thrombotic Thrombocytopenic Purpura, Congenital
Insel Gruppe AG, University Hospital Bern
Observational
450
Hamburg
2006-10
Recruiting
Pompe Disease Registry Protocol
NCT00231400Glycogen Storage Disease Type II, Pompe Disease
Genzyme, a Sanofi Company
Observational
2,000
Berlin, Bochum, Bonn, Freiburg im Breisgau, Giessen, Halle, Hamburg, Mainz
2004-09-15
By invitation
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
NCT02699736HIV, Hepatitis B, Hepatitis C, AIDS
Rigshospitalet, Denmark
Observational
23,000
Bonn, Cologne, Eppendorf, Frankfurt am Main, Hamburg, Hanover, München
1994-01
Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
NCT00358943Gaucher Disease, Cerebroside Lipidosis Syndrome, Glucocerebrosidase Deficiency Disease, Glucosylceramide Beta-Glucosidase Deficiency Disease
Genzyme, a Sanofi Company
Observational
12,000
Berlin, Düsseldorf, Giessen, Hamburg, Mainz, Oberhausen
1991-04-01
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a German investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 1 October 2026. https://priyalifescience.com/clinical-trials-germany/city/hamburg?page=2

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Germany and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 5,051 studies in total at the last sync on 26 Sep 2026, 19:51 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 889 of those studies with a site in Hamburg.

How many clinical trials are recruiting in Hamburg?

452 of the 889 studies on this page are recruiting new participants as of the 26 Sep 2026, 19:51 UTC sync. A further 34 have not yet opened recruitment, 387 are active but closed to new participants, and 16 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.