The Global Cardiovascular Risk Consortium

NCT05466825 · tracked via the Priya Life Science Germany tracker

Sponsor

Universitätsklinikum Hamburg-Eppendorf

Phase

Observational

Started

2019-09-20

Last updated

2026-02-27

Condition(s) studied

All-cause MortalityCardiovascular Disease

Study summary

The Global Cardiovascular Risk Consortium (GCVRC) brings together harmonized individual-level data from currently more than 2 million (anticipated: approximately 3 million) individuals across 133 cohorts, 40 countries, and 6 continents, with recruitment ongoing. The GCVRC examines the impact of classical cardiovascular risk factors-such as body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes-on cardiovascular disease (CVD) and death from any cause worldwide.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria: Population-based individual-level data with available information on the classical cardiovascular risk factors including body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes, as well as the outcomes of interest. Exclusion Criteria: * Participants with age below 18 years * No information on the outcome of interest * No information on the exposure of interest (CVD risk factors) * History of CVD at baseline

Primary outcome measure(s)

Cardiovascular disease (CVD) — Median follow-up of 7-10 years
Event rates of CVD and CVD subtypes: First fatal or non-fatal myocardial infarction, unstable angina, coronary revascularization, ischemic or hemorrhagic stroke, and cardiovascular or unclassifiable death. The type of outcome measurement varies across cohorts. CVD cases and subtypes are assessed by questionnaire information, national hospital discharge registry data, causes of death registry data or central death registries depending on the study protocol of the respective cohort studies.
Death from any cause — Median follow-up of 7-10 years
Number of deaths from any cause.

Trial sites (1)

Facility	City	Region	Status
University Medical Center Hamburg-Eppendorf	Hamburg	Free and Hanseatic City of Hamburg	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05466825 on ClinicalTrials.gov ↗ ← All trials in Germany