Esomeprazole clinical trials
Esomeprazole is named as an intervention in 18 current clinical trials in our China, India, South Korea, Taiwan, USA, Germany, Italy and Egypt registers. 12 are recruiting patients now. The most common phase is Phase 4. The sponsor with the most trials is Asian Institute of Gastroenterology, India (3). The most-studied condition is Helicobacter Pylori Infection.
Where Esomeprazole is approved
All regulators →Of the three regulators tracked here, the first to approve Esomeprazole was the US, on 20 Feb 2001. It is approved in 3 of the 3 regulators tracked here.
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
What health systems spend on Esomeprazole
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
How Esomeprazole works
All drug targets →- Potassium-transporting ATPase inhibitor InhibitorTarget: Potassium-transporting ATPase✓ In ChEMBL and the Guide to Pharmacology
- Helicobacter pylori infectious diseasePhase 3
- SepsisPhase 3
- Zollinger-Ellison syndromePhase 3
- Chronic gastritisPhase 3
- Duodenal ulcerPhase 3
- DyspepsiaPhase 3
- EsophagitisPhase 3
- Gastric ulcerPhase 3
- GastritisPhase 3
- OsteoarthritisPhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL1201320, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 5488, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Esomeprazole
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 36 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- EUEuropean Union: Nexium ControlEMA product information: package leaflet and summary of product characteristics in every EU language.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Esomeprazole
- ATC code
- A02BC05
- ChEMBL
- CHEMBL1201320
- DrugBank
- DB00736
- PubChem CID
- 9568614
- CAS number
- 119141-88-7
- FDA UNII
- N3PA6559FT
- Wikidata
- Q553223
- Wikipedia
- Esomeprazole
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Esomeprazole
18 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Esomeprazole across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
36 single-substance products containing Esomeprazole on the HPRA medicines list.
- Emazole 20 mg gastro-resistant tabletsRowex Limited, · PA0711/158/001 · Marketed
- Emazole 40 mg gastro-resistant tabletsRowex Limited, · PA0711/158/002 · Marketed
- Emazole Control 20 mg gastro-resistant tabletsRowex Limited, · PA0711/355/001 · Marketed
- Esomeprazole 20 mg hard gastro-resistant capsulesChefaro Ireland DAC · PA1186/027/001 · Marketed
- Esomeprazole 40 mg powder for solution injection/infusionAccord Healthcare Ireland Ltd. · PA2315/132/005 · Marketed
Supply shortages
No entry for Esomeprazole in the EMA, FDA or German BfArM shortage lists we track.
Conditions studied with Esomeprazole
31 conditionsAll 31 conditions
| Condition (as registered) | Trials |
|---|---|
| Helicobacter Pylori Infection | 4 |
| GERD | 3 |
| Healthy Volunteer | 1 |
| Pharmacokinetics | 1 |
| Safety | 1 |
| Drug-Drug Interaction (DDI) | 1 |
| Stress Ulcers | 1 |
| Reflux Episodes | 1 |
| Hematopoietic Stem Cell Transplantation (HSCT) | 1 |
| aGVHD | 1 |
| Infection | 1 |
| Mortality | 1 |
| Upper GI Bleeding | 1 |
| Proton Pump Inhibitors | 1 |
| Early Gastric Cancer | 1 |
| Gastric Dysplasia | 1 |
| Gastric Neoplasms | 1 |
| Peptic Ulcer With Haemorrhage | 1 |
| Ulcers, Gastric | 1 |
| Gastritis | 1 |
| Dyspepsia | 1 |
| Gastric Cancer | 1 |
| Helicobacter Pylori Infection Chronic Gastrit | 1 |
| Liver Cirrhosis | 1 |
| Non-Erosive Gastroesophageal Reflux Disease (NERD) | 1 |
| HELICOBACTER PYLORI INFECTIONS | 1 |
| Sex | 1 |
| Bismuth Quadruple Therapy | 1 |
| Dysbiosis | 1 |
| Probiotics | 1 |
| Laryngomalacia | 1 |
Sponsors
lead sponsor per trialBy country register
A trial with sites in more than one country appears in each of those registers.
Related compounds
Questions about Esomeprazole trials
How many clinical trials are testing Esomeprazole?
18 current trials in our China, India, South Korea, Taiwan, USA, Germany, Italy and Egypt registers name Esomeprazole as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.
Are Esomeprazole trials recruiting patients?
Yes. 12 of the 18 trials are recruiting: 5 with sites in China, 3 with sites in India, 1 with sites in South Korea, 1 with sites in USA, 1 with sites in Germany and 1 with sites in Egypt. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Esomeprazole clinical trials?
Asian Institute of Gastroenterology, India (3), National Cheng-Kung University Hospital (2), Basilea Pharmaceutica (1) and First Affiliated Hospital of Zhejiang University (1), among 15 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Is Esomeprazole licensed in Ireland?
Yes. The HPRA medicines list includes 36 single-substance products containing Esomeprazole, for example Emazole 20 mg gastro-resistant tablets (Rowex Limited,). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Esomeprazole shortage?
Not in the lists we track: Esomeprazole has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Esomeprazole works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Esomeprazole works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Esomeprazole (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.