Doxycycline clinical trials
Doxycycline is named as an intervention in 13 current clinical trials in our China, Taiwan, Singapore, USA, Brazil, South Korea, Germany, France, Spain, Turkey, Netherlands, Denmark, Australia, Israel, Canada and Mexico registers. 10 are recruiting patients now. The most common phase is Not applicable. The sponsor with the most trials is National University Hospital, Singapore (2). The most-studied condition is Acne Vulgaris. The EU clinical trials register (CTIS) separately lists 5 authorised or ongoing trials.
Where Doxycycline is approved
All regulators →Of the three regulators tracked here, the first to approve Doxycycline was the US, on 5 Dec 1967. It is approved in 2 of the 3 regulators tracked here.
- 2 EU orphan designations, most recently for treatment of familial amyloid polyneuropathy (2 Apr 2012, positive)
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
Doxycycline patents and exclusivity
Expiry tracker →Protections still running for marketed products containing Doxycycline, as listed by the regulators. Expired patents and exclusivities, and discontinued products, are not shown.
- 5 listed patents; the last listed expires 23 Dec 2034 (US 9446057).
Reproduced from the FDA Orange Book and Purple Book (checked 8 Nov 2026) and the European Commission's Union Register of medicinal products (CC BY 4.0; the EU expiry date is calculated exactly as the Commission's register displays it). Listed patents and dates are as submitted to or published by the regulator and may not reflect litigation, invalidation, settlements, lapsed fees or later extensions. This is not legal advice or a freedom-to-operate opinion, and it does not say when a generic or biosimilar will launch.
What health systems spend on Doxycycline
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
How Doxycycline works
All drug targets →- Matrix metalloproteinase 7 inhibitor InhibitorTarget: MMP7 matrix metallopeptidase 7✓ In ChEMBL and the Guide to Pharmacology
- Matrix metalloproteinase 8 inhibitor InhibitorTarget: MMP8 matrix metallopeptidase 8✓ In ChEMBL and the Guide to Pharmacology
- Matrix metalloproteinase 13 inhibitor InhibitorTarget: MMP13 matrix metallopeptidase 13ChEMBL only
- Matrix metalloproteinase-1 inhibitor InhibitorTarget: MMP1 matrix metallopeptidase 1ChEMBL only
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL2364574, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 6464, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Doxycycline
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 8 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Trials by status
Trials by phase
Clinical trials of Doxycycline
13 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Doxycycline in the EU trials register (CTIS)
5 trialsAuthorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Doxycycline. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.
Doxycycline across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
8 single-substance products containing Doxycycline on the HPRA medicines list.
- Doxycycline 100 mg hard capsulesAthlone Pharmaceuticals Limited · PA1418/010/002 · Marketed
- Doxycycline 50 mg hard capsulesAthlone Pharmaceuticals Limited · PA1418/010/001 · Marketed
- Doxycycline Bluefish 100 mg CapsulesBluefish Pharmaceuticals AB · PA1436/030/001 · Marketed
- Doxycycline Pinewood 100 mg CapsulesPinewood Laboratories Limited · PA0281/161/001 · Marketed
- Doxycycline Teva 100mg Hard CapsulesTeva B.V. · PA1986/081/001 · Marketed
Supply shortages
- Doxycycline Hyclate Tablet, Delayed ReleaseUS (FDA) · Resolved · updated 30 Jul 2026
- Doxycycline Hyclate TabletUS (FDA) · Resolved · updated 12 Jan 2026
Recent approvals
- Doxycycline HyclateFDA · 7 Oct 2019 · Generic (ANDA) · Changzhou Pharm
Conditions studied with Doxycycline
23 conditionsAll 23 conditions
| Condition (as registered) | Trials |
|---|---|
| Acne Vulgaris | 1 |
| Carcinoma, Non-Small-Cell Lung | 1 |
| Brucellosis | 1 |
| Chronic Endometritis | 1 |
| Helicobacter Pylori Infection | 1 |
| Erythematotelangiectatic Rosacea | 1 |
| Pulmonary Disease Due to Mycobacteria (Diagnosis) | 1 |
| Lactating Women on Select DOI | 1 |
| Breastfed Infants of Mothers on Select DOI | 1 |
| Sexually Transmitted Diseases | 1 |
| Syphilis | 1 |
| Gonorrhea | 1 |
| Chlamydia Infections | 1 |
| Mycoplasma Pneumoniae | 1 |
| Mycoplasma Pneumoniae Pneumonia | 1 |
| Early Syphilis, Latent, Serological Relapse After Treatment | 1 |
| Tuberculosis | 1 |
| Acute Coronary Syndrome | 1 |
| Pulmonary Hypertension (Diagnosis) | 1 |
| Tuberculosis, Meningeal | 1 |
| Tuberculosis; Meningitis (Etiology) | 1 |
| Tuberculosis, Central Nervous System | 1 |
| Tuberculosis; Meningoencephalitis (Etiology) | 1 |
Sponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| National University Hospital, Singapore | 2 |
| Integrative Skin Science and Research | 1 |
| Janssen Research & Development, LLC | 1 |
| The First Affiliated Hospital of Shihezi University | 1 |
| Fang Wang | 1 |
| Shanghai Jiao Tong University School of Medicine | 1 |
| The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 1 |
| The University of Queensland | 1 |
| Duke University | 1 |
| Oswaldo Cruz Foundation | 1 |
| Young June Choe | 1 |
| National Taiwan University Hospital | 1 |
By country register
A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.
Related compounds
Questions about Doxycycline trials
How many clinical trials are testing Doxycycline?
13 current trials in our China, Taiwan, Singapore, USA, Brazil, South Korea, Germany, France, Spain, Turkey, Netherlands, Denmark, Australia, Israel, Canada and Mexico registers name Doxycycline as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.
Are Doxycycline trials recruiting patients?
Yes. 10 of the 13 trials are recruiting: 3 with sites in China, 2 with sites in Taiwan, 3 with sites in Singapore, 1 with sites in USA, 1 with sites in Brazil, 1 with sites in Netherlands, 1 with sites in Denmark, 1 with sites in Australia, 1 with sites in Israel, 1 with sites in Canada and 1 with sites in Mexico. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Doxycycline clinical trials?
National University Hospital, Singapore (2), Integrative Skin Science and Research (1), Janssen Research & Development, LLC (1) and The First Affiliated Hospital of Shihezi University (1), among 12 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Is Doxycycline licensed in Ireland?
Yes. The HPRA medicines list includes 8 single-substance products containing Doxycycline, for example Doxycycline 100 mg hard capsules (Athlone Pharmaceuticals Limited). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Doxycycline shortage?
The registers we track list 2 entries for Doxycycline: US FDA: resolved; US FDA: resolved. Shortages are product- and country-specific; check with a pharmacist.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Doxycycline works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Doxycycline works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Doxycycline (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.