Adapalene clinical trials
Adapalene is named as an intervention in 2 current clinical trials in our China and Egypt registers. 1 is recruiting patients now. The most common phase is Early Phase 1. The sponsor with the most trials is Yunnan Cancer Hospital (1). The most-studied condition is Dermatitis, Radiation-Induced.
Where Adapalene is approved
All regulators →Of the three regulators tracked here, the first to approve Adapalene was Canada, on 24 Jan 1995. It is approved in 2 of the 3 regulators tracked here.
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
What health systems spend on Adapalene
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
Patient leaflets for Adapalene
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 6 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Trials by status
Trials by phase
Clinical trials of Adapalene
2 trials| Study | Phase | Status | Lead sponsor | Registers |
|---|---|---|---|---|
|
Adapalene Gel for Acute Radiation-Induced Skin Injury
NCT07886320 · ClinicalTrials.gov ↗ · Dermatitis, Radiation-Induced, Adapalene
|
Early Phase 1 | Recruiting | Yunnan Cancer Hospital | China |
|
Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study
NCT07473895 · ClinicalTrials.gov ↗ · Acne Vulgaris
|
Phase 2 | Not yet open | Assiut University | Egypt |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Adapalene across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
6 single-substance products containing Adapalene on the HPRA medicines list.
- Differin 0.1% w/w GelGalderma International · PA22743/005/002 · Marketed
- Differin 0.1% w/w CreamPCO Manufacturing Ltd. · PPA0465/437/002
- Differin 0.1% w/w creamIMED Healthcare Ltd., · PPA1463/120/001
- Differin 0.1% w/w gelPCO Manufacturing Ltd. · PPA0465/437/001
- Differin 0.1% w/w gelIMED Healthcare Ltd., · PPA1463/120/002
Supply shortages
No entry for Adapalene in the EMA, FDA or German BfArM shortage lists we track.
Conditions studied with Adapalene
3 conditionsSponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| Yunnan Cancer Hospital | 1 |
| Assiut University | 1 |
By country register
| Register | Trials | Recruiting |
|---|---|---|
| Clinical trials in China | 1 | 1 |
| Clinical trials in Egypt | 1 | 0 |
A trial with sites in more than one country appears in each of those registers.
Related compounds
Questions about Adapalene trials
How many clinical trials are testing Adapalene?
2 current trials in our China and Egypt registers name Adapalene as a drug or biological intervention, as of the registry sync on 22 October 2026. Completed and withdrawn studies are not counted.
Are Adapalene trials recruiting patients?
Yes. 1 of the 2 trials is recruiting: 1 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Adapalene clinical trials?
Yunnan Cancer Hospital (1) and Assiut University (1). The number in brackets is how many trials each organisation leads.
Is Adapalene licensed in Ireland?
Yes. The HPRA medicines list includes 6 single-substance products containing Adapalene, for example Differin 0.1% w/w Gel (Galderma International). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Adapalene shortage?
Not in the lists we track: Adapalene has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Adapalene works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Adapalene works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Adapalene (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 22 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.