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Trackers› Clinical trials› Minnesota
Clinical trial register · United States · industry-sponsored

Clinical Trials in Minnesota, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca36 Novartis Pharmaceuticals23 AbbVie19 Eli Lilly and Company18 Bristol-Myers Squibb16
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Minnesota

924 of 9118 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Recruiting
A Study of Participants with Β-Thalassemia Treated with Betibeglogene Autotemcel
NCT06271512Beta-Thalassemia
Genetix Biotherapeutics Inc.
Observational
150
California, Minnesota, New York, Pennsylvania, Texas
2024-01-23
Recruiting
A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia
NCT06079398Achondroplasia
DrugNavepegritide
Ascendis Pharma A/S
Phase 2
72
Minnesota, Texas, Wisconsin
2024-01-23
Active, closed
Ph2 Open-label Study of AOC 1044 in Duchenne Muscular Dystrophy Participants With Mutations Amenable to Exon44 Skipping
NCT06244082DMD, Duchenne Muscular Dystrophy, Duchenne, Exon 44
DrugAOC 1044
Avidity Biosciences, Inc.
Phase 2
39
Arkansas, California, Georgia, Massachusetts, Minnesota, North Carolina, Ohio, Texas
2024-01-22
Recruiting
A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas
NCT05641844Anal Fistula
RedDress Ltd.
Not applicable
110
California, Florida, Illinois, Indiana, Massachusetts, Minnesota, New York, Pennsylvania
2024-01-20
Active, closed
Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)
NCT06181240Coronary Artery Disease, Coronary Artery Calcification
Bolt Medical
Not applicable
426
California, Colorado, Florida, Georgia, Massachusetts, Michigan, Minnesota, Mississippi
2024-01-19
Recruiting
Comparing Use of Incentive Spirometry With and Without Reminder
NCT06101030Post Operative
Tidal Medical Technologies
Observational
500
Maryland, Minnesota, New Jersey
2024-01-16
Recruiting
A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).
NCT05919680Intestinal Failure Associated Liver Disease
NorthSea Therapeutics B.V.
Phase 2
36
Arizona, California, District of Columbia, Georgia, Illinois, Massachusetts, Michigan, Minnesota
2024-01-15
Active, closed
A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)
NCT06109272Hepatocellular Carcinoma
DrugsLivmoniplimab·Budigalimab·Tremelimumab·Atezolizumab
AbbVie
Phase 2/3
89
California, Illinois, Kansas, Kentucky, Michigan, Minnesota, Missouri, Texas
2024-01-11
By invitation
Complex Aneurysm Registry - Real-World Evidence Data Collection Intracranial Aneurysm Treatment Devices
NCT06215105Aneurysm Cerebral
Microvention-Terumo, Inc.
Observational
750
Florida, Iowa, Minnesota, New York
2024-01-08
Recruiting
FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors
NCT06241456Advanced Solid Tumor
DrugsFludara·Bendamustine·Cetuximab·Fludarabine
Fate Therapeutics
Phase 1
351
Arizona, California, Connecticut, Illinois, Michigan, Minnesota, Missouri, New York
2024-01-05
Active, closed
Pasireotide s.c. in Patients With Post-Bariatric Hypoglycaemia
NCT05928390Post-Bariatric Hypoglycemia
RECORDATI GROUP
Phase 2
93
California, Illinois, Louisiana, Maryland, Massachusetts, Minnesota, New York, Tennessee
2024-01-04
By invitation
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
NCT06191315Wheezing, Asthma
DrugDupilumab
Sanofi
Phase 3
90
Arizona, Florida, Illinois, Kentucky, Minnesota, New York, North Carolina, Ohio
2024-01-03
Recruiting
SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study
NCT06001827Chronic Kidney Diseases, End Stage Renal Disease, Arteriovenous Fistula, Hemodialysis Access Failure
VenoStent
Not applicable
600
Arizona, California, Florida, Indiana, Kentucky, Massachusetts, Minnesota, Missouri
2024-01-03
Recruiting
A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas
NCT06090539Relapsed/Refractory Non-Hodgkin Lymphoma
DrugsGolcadomide·Mosunetuzumab·Epcoritamab·Truxima
Bristol-Myers Squibb
Phase 1/2
460
Arizona, California, Florida, Massachusetts, Minnesota, Nebraska, New York, Rhode Island
2023-12-29
Active, closed
Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
NCT06046222Eosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome
NS Pharma, Inc.
Phase 2
45
Colorado, Minnesota, Ohio, Pennsylvania, South Carolina, Tennessee
2023-12-20
Active, closed
Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma
NCT05948475Cholangiocarcinoma
DrugTinengotinib
TransThera Sciences (Nanjing), Inc.
Phase 3
200
California, Florida, Illinois, Massachusetts, Michigan, Minnesota, New York, North Carolina
2023-12-20
Active, closed
Clinical Evaluation of the i-STAT ACTpro Cartridge in an Adult Population
NCT07382076Activated Clotting Time
Abbott Point of Care
Observational
500
Arizona, California, District of Columbia, Kentucky, Maryland, Minnesota, Missouri, New York
2023-12-15
Active, closed
A Phase I/II Study to Evaluate AZD5851 in GPC3+ Advanced/Recurrent Hepatocellular Carcinoma
NCT06084884Hepatocellular Carcinoma
DrugAZD5851
AstraZeneca
Phase 1/2
94
Arizona, California, District of Columbia, Florida, Georgia, Kansas, Minnesota, New Jersey
2023-12-14
Active, closed
Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab
NCT06011109Glioma, Glioblastoma Multiforme
DrugAPG-157
Aveta Biomics, Inc.
Phase 1/2
30
Minnesota, Nebraska
2023-12-13
Active, closed
A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
NCT05734105GIST
DrugsRipretinib·Sunitinib
Deciphera Pharmaceuticals, LLC
Phase 3
54
California, Connecticut, Florida, Maryland, Massachusetts, Minnesota, New York, Ohio
2023-12-13
Active, closed
A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD
NCT07116889Asthma, COPD (Chronic Obstructive Pulmonary Disease)
DrugGB-0895
Generate Biomedicines
Phase 1
156
Florida, Minnesota, North Carolina, Texas
2023-12-12
Active, closed
Safety and Efficacy of TSHA-102 in Pediatric Females With Rett Syndrome (REVEAL Pediatric Study)
NCT06152237Rett Syndrome
Taysha Gene Therapies, Inc.
Phase 1/2
6
Illinois, Minnesota, Missouri
2023-12-12
Recruiting
A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors
NCT06253130Advanced Solid Tumor
Eikon Therapeutics
Phase 1/2
156
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Michigan, Minnesota
2023-12-11
Active, closed
A Study to Investigate the Efficacy and Safety of OTL-203 in Subjects With MPS-IH Compared With Standard of Care With Allogeneic HSCT
NCT06149403MPS-IH (Hurler Syndrome)
Orchard Therapeutics
Phase 3
41
Minnesota
2023-12-11
Recruiting
A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease
NCT05995353Crohn's Disease
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
110
Arizona, Arkansas, California, Colorado, Florida, Indiana, Massachusetts, Minnesota
2023-12-11
Active, closed
F15 Recharge Free Axonics SNM System Clinical Study
NCT06186765Urinary Urge Incontinence (UUI), Urinary Frequency (UF), Fecal Incontinence (FI)
Axonics, Inc.
Not applicable
144
Connecticut, Florida, Georgia, Minnesota, Nebraska, New York, Oregon, South Carolina
2023-12-08
Active, closed
A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma
NCT06007690Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
DrugBel-sar
Aura Biosciences
Phase 3
108
California, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota, Missouri
2023-12-06
Active, closed
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
NCT06029972Ulcerative Colitis
Gilead Sciences
Phase 2
176
Arizona, California, Florida, Michigan, Minnesota, Mississippi, Missouri, New York
2023-12-05
Active, closed
A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer
NCT06005740Advanced Solid Tumor, Hepatocellular Carcinoma
TORL Biotherapeutics, LLC
Phase 1
70
Arizona, California, Florida, Minnesota, Virginia
2023-12-04
Active, closed
A Study Assessing Esophageal Function and Remodeling With Dupilumab Compared With Placebo for 24 Weeks Followed by 104 Weeks Open Label in Adult Participants With EoE (REMOdeling With Dupilumab in Eosinophilic Esophagitis Long-term Trial)
NCT06101095Eosinophilic Oesophagitis
DrugDupilumab
Sanofi
Phase 4
69
California, Florida, Idaho, Illinois, Iowa, Massachusetts, Minnesota, North Carolina
2023-11-29
Recruiting
A Multicenter Multinational Observational Study of Children With Hypochondroplasia
NCT06212947Hypochondroplasia
BioMarin Pharmaceutical
Observational
400
Arizona, California, Delaware, District of Columbia, Illinois, Maryland, Massachusetts, Minnesota
2023-11-27
By invitation
A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies
NCT06208878Hematologic Malignancy, Solid Malignancy
CRISPR Therapeutics AG
Observational
70
California, Connecticut, Georgia, Illinois, Kansas, Minnesota, Missouri, New York
2023-11-22
Recruiting
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
NCT06131840Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Pancreatic Ductal Adenocarcinoma
DrugsLeucovorin·Adrucil·Oxaliplatin·Bevacizumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 1
914
Arizona, California, Colorado, Florida, Maryland, Massachusetts, Michigan, Minnesota
2023-11-20
Active, closed
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
NCT06074588Non-small Cell Lung Cancer (NSCLC)
DrugsTaxotere·Sacituzumab tirumotecan·Pemetrexed·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
556
California, Florida, Georgia, Michigan, Minnesota, Mississippi, Nebraska, New Jersey
2023-11-12
Active, closed
Study of Multiple-Ascending-Dose Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extrapulmonary Manifestations
NCT05890729Pulmonary Sarcoidosis
Xentria, Inc.
Phase 1/2
32
Alabama, Colorado, Florida, Illinois, Iowa, Maryland, Michigan, Minnesota
2023-11-10
Active, closed
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
NCT06097728Unresectable Pleural Mesothelioma
DrugsVolrustomig·Yervoy·Paraplatin·Ipilimumab
AstraZeneca
Phase 3
863
California, Colorado, Florida, Georgia, Illinois, Minnesota, Missouri, New York
2023-11-09
Active, closed
Phase I/II Study of [225Ac]Ac-PSMA-R2 in PSMA-positive Prostate Cancer, With/Without Prior 177Lu-PSMA RLT
NCT05983198Prostate Cancer
Novartis Pharmaceuticals
Phase 1
33
Minnesota
2023-11-07
Active, closed
A Study of JNJ-90009530 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (r/r B-NHL)
NCT05784441Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
Janssen Research & Development, LLC
Phase 1
21
Iowa, Kentucky, Minnesota, New Jersey, Ohio, Pennsylvania, Texas
2023-11-06
Recruiting
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
NCT05938465Ileal Pouch
Exegi Pharma, LLC
Phase 1/2
50
California, Florida, Michigan, Minnesota, Missouri, New York, North Carolina, Pennsylvania
2023-11-06
Active, closed
TheraSphere With Durvalumab and Tremelimumab for HCC
NCT05063565Hepatocellular Carcinoma
Boston Scientific Corporation
Phase 2
100
California, District of Columbia, Florida, Illinois, Louisiana, Minnesota, Missouri, New York
2023-11-03
Recruiting
A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer
NCT06095089Prostatic Neoplasms
DrugsJNJ-101556143·JNJ-87189401·Lutetium Lu-177 vipivotide tetraxetan·Pasritamig
Janssen Research & Development, LLC
Phase 1
355
Colorado, Georgia, Minnesota, New Jersey, New York, North Carolina, Oregon, Pennsylvania
2023-11-01
Active, closed
A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers
NCT05873686Advanced Solid Tumor, NSCLC (Non-small Cell Lung Cancer), Renal Cancer, Mesothelioma
DrugNXP900
Nuvectis Pharma, Inc.
Phase 1
140
Arizona, California, Colorado, Florida, Illinois, Minnesota, New York, Ohio
2023-10-26
Recruiting
IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancers
NCT06119685NHL, Multiple Myeloma, Blood Cancer, Refractory Non-Hodgkin Lymphoma
DrugsMesna·Darzalex·Isatuximab·Aldesleukin
Indapta Therapeutics, INC.
Phase 1/2
128
California, Florida, Georgia, Minnesota, New York, North Carolina, Ohio, Oregon
2023-10-25
Recruiting
An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
NCT05106387Chronic Kidney Disease (CKD)
DrugVonsetamig
Regeneron Pharmaceuticals
Observational
20
California, Connecticut, Illinois, Maryland, Minnesota, New York, Pennsylvania
2023-10-19
Recruiting
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
NCT06026410Solid Tumors With HRAS Alterations, Non Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)
DrugsAdagrasib·Cabozantinib
Kura Oncology, Inc.
Phase 1
300
Arizona, California, Colorado, Florida, Iowa, Massachusetts, Michigan, Minnesota
2023-10-18
Active, closed
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Epidermolysis Bullosa (Phase III)
NCT05838092Epidermolysis Bullosa
DrugAllo-APZ2-OTS
RHEACELL GmbH & Co. KG
Phase 3
9
Colorado, Minnesota
2023-10-18
Active, closed
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
NCT06075667Obesity, Overweight
DrugTirzepatide
Eli Lilly and Company
Phase 3
160
Georgia, Idaho, Kansas, Louisiana, Maryland, Minnesota, Missouri, Ohio
2023-10-16
Active, closed
A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation
NCT06045806Multiple Myeloma
DrugsIdecabtagene vicleucel·Endoxan·Fludara·Cytoxan
Celgene
Phase 3
79
California, Colorado, Connecticut, Florida, Georgia, Massachusetts, Michigan, Minnesota
2023-10-16
Active, closed
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
NCT05891171Advanced Cancer, Advanced Malignancies, Bladder Cancer, Cervical Cancer
DrugsZimberelimab·Fluorouracil·Leucovorin·Oxaliplatin
Arcus Biosciences, Inc.
Phase 1
40
Arizona, Florida, Illinois, Michigan, Minnesota, New Jersey, Ohio, Texas
2023-10-13
Recruiting
Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN
NCT05755386IC-MPGN
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
106
California, Colorado, Florida, Georgia, Massachusetts, Minnesota, Missouri, New Mexico
2023-10-02
Active, closed
A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT06161584Geographic Atrophy
DrugsSyfovre·Pegcetacoplan
Apellis Pharmaceuticals, Inc.
Observational
300
California, Colorado, Florida, Georgia, Illinois, Maryland, Minnesota, New Jersey
2023-09-28
Recruiting
Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors
NCT05636618Neuroendocrine Tumors Unresectable, Neuroendocrine Tumor Metastatic, Gastroenteropancreatic Neuroendocrine Tumor, Bronchial Neuroendocrine Tumor
Perspective Therapeutics
Phase 1/2
300
Florida, Illinois, Iowa, Kentucky, Maryland, Michigan, Minnesota, Missouri
2023-09-27
Active, closed
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
NCT05911295Urothelial Carcinoma
DrugsDisitamab Vedotin·Keytruda·Gemcitabine·Cisplatin
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
412
Arizona, California, Minnesota, Pennsylvania, Texas, Washington
2023-09-22
Active, closed
Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)
NCT06088290Leiomyosarcoma
DrugsLurbinectedin·Doxorubicin
PharmaMar
Phase 3
469
Arizona, California, Colorado, Florida, Georgia, Massachusetts, Michigan, Minnesota
2023-09-21
Active, closed
Real World Registry for Use of the Ion Endoluminal System
NCT06004440Lung Cancer, Multiple Pulmonary Nodules, Lung Neoplasms, Respiratory Tract Neoplasms
Intuitive Surgical
Observational
1,301
Florida, Illinois, Kansas, Louisiana, Michigan, Minnesota, New York, North Carolina
2023-09-21
Active, closed
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
NCT05869955Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis, Rheumatoid Arthritis
DrugsZola-cel·Tocilizumab·Fludarabine·Cyclophosphamide
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Phase 1
270
Colorado, Florida, Illinois, Massachusetts, Michigan, Minnesota, Missouri, Nebraska
2023-09-13
Recruiting
LAM-001 for the Treatment of Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
NCT05798923Pulmonary Hypertension Due to Lung Diseases and Hypoxia
OrphAI Therapeutics
Phase 2
85
Alabama, Arizona, Colorado, Connecticut, Florida, Massachusetts, Minnesota, Nebraska
2023-08-30
Recruiting
ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis
NCT05878860X-linked Retinoschisis
Atsena Therapeutics Inc.
Phase 3
97
Arizona, California, Florida, Massachusetts, Michigan, Minnesota, New York, North Carolina
2023-08-22
Recruiting
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
NCT06355934ATTR Amyloidosis
AstraZeneca
Observational
52,121
Minnesota
2023-08-21
Recruiting
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
NCT05914116Advanced Solid Tumors
DrugsBNT324·Itraconazole·Abiraterone·Enzalutamide
DualityBio Inc.
Phase 1/2
862
Arizona, California, Florida, Georgia, Kentucky, Michigan, Minnesota, Nevada
2023-08-17
By invitation
Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older
NCT05844449Cystic Fibrosis
DrugVNZ/TEZ/D-IVA
Vertex Pharmaceuticals Incorporated
Phase 3
174
California, Colorado, Georgia, Illinois, Indiana, Massachusetts, Minnesota, Missouri
2023-08-11
Recruiting
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
NCT05836259Hypertrophic Cardiomyopathy
Tenaya Therapeutics
Phase 1/2
30
California, Georgia, Massachusetts, Minnesota, Ohio, Oregon, Pennsylvania, Texas
2023-08-10
Active, closed
A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)
NCT05818553SCN2A Encephalopathy, SCN8A Encephalopathy
DrugRelutrigine
Praxis Precision Medicines
Phase 2/3
77
Georgia, Illinois, Minnesota, New Jersey
2023-08-02
Recruiting
A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors
NCT05954312Advanced Solid Tumors
DrugsDocetaxel·Paclitaxel·Pembrolizumab
Vividion Therapeutics, Inc.
Phase 1
290
Florida, Minnesota, Tennessee, Texas, Virginia
2023-07-28
Active, closed
Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy
NCT05949593Geographic Atrophy
DrugTinlarebant
Belite Bio, Inc
Phase 3
429
Arizona, California, Florida, Maryland, Minnesota, New York, North Carolina, Oregon
2023-07-27
Active, closed
Abbott Ventricular Tachycardia PAS
NCT05839873Ventricular Tachycardia
Abbott Medical Devices
Observational
62
Florida, Indiana, Kansas, Massachusetts, Minnesota, North Carolina, Oklahoma, South Carolina
2023-07-24
Recruiting
Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
NCT05797831Endometrial Cancer
DrugNavtemadlin
Kartos Therapeutics, Inc.
Phase 2/3
268
California, Georgia, Illinois, Indiana, Maryland, Minnesota, Missouri, Nevada
2023-07-17
Recruiting
Safety and Feasibility Study of the CELLSPAN Esophageal Implant (CEI) in Patients Requiring Short Segment Esophageal Replacement
NCT05877300Esophageal Diseases
Harvard Apparatus Regenerative Technology, Inc.
Phase 1
10
California, Michigan, Minnesota
2023-07-13
Active, closed
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
NCT05819866Cerebral Adrenoleukodystrophy (cALD)
Minoryx Therapeutics, S.L.
Phase 3
40
California, Maryland, Massachusetts, Minnesota
2023-07-12
Recruiting
Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
NCT06005493Gastric Cancer, Gastro-esophageal Junction Cancer, Pancreatic Ductal Adenocarcinoma, Esophageal Adenocarcinoma
DrugRilvegostomig
AstraZeneca
Phase 1/2
392
Florida, Minnesota, New York
2023-07-11
Recruiting
Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
NCT05552755Familial Adenomatous Polyposis
Recursion Pharmaceuticals Inc.
Phase 1/2
67
Arizona, California, Florida, Indiana, Louisiana, Michigan, Minnesota, Missouri
2023-07-10
Recruiting
Study of Enterra Programming with Nocturnal Cycling in Gastroparetics
NCT05980455Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus
Enterra Medical, Inc.
Not applicable
50
Kentucky, Minnesota
2023-07-10
Active, closed
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
NCT05726227Obesity
DrugSemaglutide
Novo Nordisk A/S
Phase 3
210
California, Connecticut, Georgia, Idaho, Louisiana, Maryland, Massachusetts, Minnesota
2023-07-07
Active, closed
A Study of Zigakibart in Adults With IgA Nephropathy
NCT05852938IgA Nephropathy, Immunoglobulin A Nephropathy
DrugZigakibart
Novartis Pharmaceuticals
Phase 3
383
Alabama, California, Colorado, Florida, Illinois, Indiana, Iowa, Minnesota
2023-07-06
Active, closed
(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma
NCT05907954Uveal Melanoma
DrugDarovasertib
IDEAYA Biosciences
Phase 2
160
Arizona, California, Florida, Michigan, Minnesota, New York, Pennsylvania, Tennessee
2023-07-03
Active, closed
Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to a DMARD Starting a New bDMARD or tsDMARD Treatment +/- csDMARD
NCT05936970Rheumatoid Arthritis
Aqtual, Inc.
Observational
1,410
Arizona, California, Florida, Idaho, Illinois, Indiana, Michigan, Minnesota
2023-06-29
Recruiting
DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors
NCT05785754Advanced or Metastatic Solid Tumors
DrugsDCSZ11·Tebentafusp·Doxorubicin·Pembrolizumab
DynamiCure Biotechnology
Phase 1
320
Alabama, Arizona, Colorado, Connecticut, Florida, Maryland, Massachusetts, Minnesota
2023-06-28
Active, closed
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
NCT05787821Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Observational
760
Colorado, Florida, Georgia, Kentucky, Michigan, Minnesota, Mississippi, New Mexico
2023-06-28
Active, closed
A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors
NCT05812027Head and Neck Cancer, Cervical Cancer, Non Small Cell Lung Cancer, HPV16 Related Cancers
TScan Therapeutics, Inc.
Observational
1,150
Arizona, California, Connecticut, Florida, Illinois, Kentucky, Michigan, Minnesota
2023-06-26
By invitation
A Clinical Trial to Investigate Long-term Safety, Tolerability, and Efficacy of Weekly Subcutaneous Doses With TransCon CNP in Children and Adolescents With Achondroplasia
NCT05929807Achondroplasia
Ascendis Pharma Growth Disorders A/S
Phase 2/3
140
Arkansas, Colorado, Delaware, Minnesota, Montana, New York, Texas, Wisconsin
2023-06-21
Active, closed
Early Feasibility Study of the NORM™ System in Heart Failure Patients (FUTURE-HFII)
NCT05763407Heart Failure
Foundry Innovation & Research 1, Limited (FIRE1)
Not applicable
25
Minnesota, New York, North Carolina, Ohio, South Carolina, Texas
2023-06-19
Active, closed
Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism
NCT05778071Chronic Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases
Alexion Pharmaceuticals, Inc.
Phase 3
165
California, Colorado, Illinois, Indiana, Massachusetts, Minnesota, Nevada, New York
2023-06-07
Active, closed
Pelvic Fixation and Fusion During Multilevel Spinal Surgery
NCT05640908Spinal Fusion, Deformity of Spine
SI-BONE, Inc.
Observational
200
Alabama, Colorado, Michigan, Minnesota, New York, North Carolina, Texas
2023-06-05
Recruiting
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
NCT05655312Recurrent Melanoma (Skin), Metastatic Melanoma, Melanoma Stage IV, Melanoma Stage III
DrugNivolumab
Perspective Therapeutics
Phase 1/2
300
California, Florida, Iowa, Kentucky, Minnesota, Missouri, Nebraska, Pennsylvania
2023-06-01
Active, closed
Study to Evaluate the Efficacy and Safety of BBP-418 (Ribitol) in Patients With Limb Girdle Muscular Dystrophy 2I (LGMD2I)
NCT05775848Limb-Girdle Muscular Dystrophy Type 2I (LGMD2I)
DrugRibitol
ML Bio Solutions, Inc.
Phase 3
112
Arkansas, California, Colorado, Florida, Iowa, Kansas, Maryland, Minnesota
2023-05-31
Recruiting
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
NCT05824975Advanced Solid Tumor, Metastatic Solid Tumor, Soft Tissue Sarcoma (STS), Platinum-resistant Ovarian Cancer (PROC)
DrugsEribulin·Trastuzumab deruxtecan·Doxorubicin·Keytruda
GI Innovation, Inc.
Phase 1/2
358
Arizona, Florida, Minnesota, New York, Ohio
2023-05-30
Active, closed
Water Vapor Ablation for Localized Intermediate Risk Prostate Cancer
NCT05683691Prostate Cancer
Francis Medical Inc.
Not applicable
400
Arizona, California, Florida, Illinois, Kansas, Maryland, Michigan, Minnesota
2023-05-16
Recruiting
XTX301 in Patients With Advanced Solid Tumors
NCT05684965Advanced Solid Tumor
Xilio Development, Inc.
Phase 1/2
358
California, Connecticut, Minnesota, Missouri, New Jersey, Ohio, Pennsylvania, Texas
2023-05-11
Active, closed
Robotic vs. Open NSM for Early Stage Breast Cancer
NCT05720039Breast Cancer Female, Breast Cancer, Breast Cancer, Early-Onset, Breast Disease
Intuitive Surgical
Not applicable
204
California, Florida, Georgia, Illinois, Michigan, Minnesota, Missouri, New York
2023-05-08
Active, closed
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
NCT05552469Myeloid Diseases
Novartis Pharmaceuticals
Phase 1
71
California, Florida, Illinois, Maryland, Massachusetts, Minnesota, New York, Tennessee
2023-05-08
Active, closed
Phase III Study of AK112 for NSCLC Patients
NCT06396065Non-Squamous Non-small Cell Lung Cancer
DrugsIvonescimab·Pemetrexed·Carboplatin
Summit Therapeutics
Phase 3
420
California, Colorado, Florida, Louisiana, Maine, Maryland, Massachusetts, Minnesota
2023-05-04
Recruiting
The Ailliance Post-Market Clinical Study
NCT05856370Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma
Medtronic Spinal and Biologics
Not applicable
1,000
Arizona, Arkansas, California, Indiana, Kentucky, Maryland, Michigan, Minnesota
2023-05-01
Active, closed
A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression
NCT05736731Solid Tumor, Adult, Solid Tumor, Pancreatic Cancer, Pancreatic Neoplasms
A2 Biotherapeutics Inc.
Phase 1/2
160
Arizona, California, Florida, Minnesota, Missouri, New York, Texas
2023-04-28
Active, closed
A Trial of Setmelanotide in Acquired Hypothalamic Obesity
NCT05774756Hypothalamic Obesity
DrugSetmelanotide
Rhythm Pharmaceuticals, Inc.
Phase 3
143
Alabama, California, Colorado, Florida, Illinois, Iowa, Massachusetts, Minnesota
2023-04-26
Active, closed
A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL)
NCT05512390Diffuse Large B-Cell Lymphoma, Chronic Lymphocytic Leukemia, Follicular Lymphoma
DrugABBV-319
AbbVie
Phase 1
39
Arizona, Florida, Minnesota, Nebraska, New York, North Carolina, Texas
2023-04-26
Recruiting
A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes
NCT05732103Acute Myeloid Leukemia, Myelodysplastic Syndromes
Chordia Therapeutics, Inc.
Phase 1/2
225
Arizona, Florida, Illinois, Minnesota, New York, Texas, Virginia, Washington
2023-04-25
Recruiting
Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
NCT05765175Tachycardia, Ventricular
Varian, a Siemens Healthineers Company
Not applicable
380
California, Connecticut, Massachusetts, Minnesota, Missouri, Ohio, Pennsylvania, South Carolina
2023-04-21
Recruiting
Pounce™ Thrombectomy System Retrospective Registry
NCT05868161Peripheral Arterial Disease, Acute Limb Ischemia
SurModics, Inc.
Observational
500
Illinois, Indiana, Louisiana, Minnesota, Ohio, South Carolina, South Dakota, Tennessee
2023-04-18
Active, closed
A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy
NCT05707377Primary Membranous Nephropathy
DrugsTacrolimus·Zanubrutinib
BeOne Medicines
Phase 2/3
178
California, Minnesota, Nevada
2023-04-17
Recruiting
ISP-001: Sleeping Beauty Transposon-Engineered B Cells for MPS I
NCT05682144Mucopolysaccharidosis IH/S, Mucopolysaccharidosis IS
Immusoft of CA, Inc.
Phase 1
11
California, Minnesota
2023-04-12
Recruiting
An Extension Study Assessing the Safety and Efficacy of AVTX-803 in Subjects With Leukocyte Adhesion Deficiency Type II
NCT05754450Leukocyte Adhesion Deficiency
DrugL-Fucose
AUG Therapeutics
Phase 3
2
Minnesota
2023-04-10
Recruiting
Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant
NCT05654922Pre-Bronchiolitis Obliterans Syndrome
Renovion, Inc.
Phase 3
100
Arizona, California, Florida, Illinois, Iowa, Maryland, Minnesota, Missouri
2023-04-10
Active, closed
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
NCT05794906Biochemically Recurrent Prostate Cancer
DrugDarolutamide
Bayer
Phase 3
985
Arizona, California, Colorado, Illinois, Maryland, Massachusetts, Michigan, Minnesota
2023-04-03
Active, closed
ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
NCT05686317Heart Failure
Edwards Lifesciences
Not applicable
100
California, Illinois, Kansas, Minnesota, New York, Ohio, Oklahoma, Oregon
2023-04-01
Active, closed
To Understand the Safety and Effects of a C. Difficile Vaccine With New Adds-Ons That Will Be Given to Healthy Adults
NCT05805826Clostridoides Difficile Associated Disease
Pfizer
Phase 1/2
936
Arizona, California, Florida, Illinois, Kansas, Minnesota, Missouri, New York
2023-03-23
Recruiting
A Study of ASP1002 in Adults for Treatment of Solid Tumors
NCT05719558Advanced Solid Tumors
DrugsRamucirumab·Trifluridine/Tipiracil·Fluorouracil·Leucovorin
Astellas Pharma Global Development, Inc.
Phase 1
798
Connecticut, Florida, Iowa, Kentucky, Michigan, Minnesota, New York, Ohio
2023-03-13
Active, closed
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
NCT05625399Melanoma
DrugsPhesgo·Relatlimab·Nivolumab
Bristol-Myers Squibb
Phase 3
579
Arizona, Arkansas, California, Colorado, Florida, Maryland, Minnesota, Nebraska
2023-03-06
Active, closed
A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
NCT05668741Cystic Fibrosis
DrugIvacaftor
Vertex Pharmaceuticals Incorporated
Phase 1/2
26
Alabama, California, Colorado, Kansas, Maryland, Massachusetts, Minnesota, Missouri
2023-02-27
Recruiting
R-3750 in Patients With Mild to Moderate Ulcerative Colitis
NCT05666960Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic, Ulcerative Colitis
Rise Therapeutics LLC
Phase 1
36
California, Florida, Minnesota
2023-02-27
Recruiting
A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma
NCT05651932Multiple Myeloma, Myeloma, Myeloma Multiple
DrugsMezigdomide·Carfilzomib·Pomalidomide·Dexamethasone
K36 Therapeutics, Inc.
Phase 1
165
California, Florida, Georgia, Massachusetts, Minnesota, New Jersey, New York, North Carolina
2023-02-22
Recruiting
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
NCT05503797Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors
Fore Biotherapeutics
Phase 2
254
California, Connecticut, Florida, Maryland, Massachusetts, Minnesota, Missouri, Nebraska
2023-02-21
By invitation
Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C
NCT05905926Irritable Bowel Syndrome With Constipation (IBS-C)
DrugTenapanor
Ardelyx
Phase 3
150
Alabama, California, Florida, Illinois, Indiana, Maine, Minnesota, Nebraska
2023-02-17
Active, closed
A Trial to Investigate Different Doses of Lonapegsomatropin Compared to Somatropin in Individuals With Turner Syndrome
NCT05690386Turner Syndrome
DrugSomatropin
Ascendis Pharma Endocrinology Division A/S
Phase 2
48
California, Colorado, Florida, Georgia, Idaho, Illinois, Massachusetts, Minnesota
2023-02-15
Active, closed
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
NCT05711940Treatment Resistant Depression
DrugPsilocybin
COMPASS Pathways
Phase 3
572
Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota
2023-02-14
Active, closed
(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer
NCT05607004Breast Neoplasms, Invasive Breast Cancer, Estrogen-receptor-positive Breast Cancer, HER2-negative Breast Cancer
DrugsZoladex·Goserelin
Atossa Therapeutics, Inc.
Phase 2
87
Arizona, California, Florida, Illinois, Kentucky, Michigan, Minnesota, Missouri
2023-02-14
Active, closed
Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)
NCT05609968Carcinoma, Non-Small-Cell Lung
DrugsSacituzumab Govitecan·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
614
Alabama, California, Florida, Georgia, Louisiana, Michigan, Minnesota, New York
2023-02-06
Active, closed
Pilot/Pivotal Study of DBS+Rehab After Stroke
NCT05701280Stroke, Upper Extremity Paresis
Enspire DBS Therapy, Inc.
Not applicable
202
Arizona, Maryland, Massachusetts, Minnesota, New York, Ohio, Pennsylvania, Rhode Island
2023-02-03
Active, closed
A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9
NCT05723835SGA, Turner Syndrome, Noonan Syndrome, ISS
DrugSomapacitan
Novo Nordisk A/S
Phase 3
47
Alabama, California, Colorado, District of Columbia, Idaho, Minnesota
2023-02-01
Active, closed
A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adolescent or Adult Participants With Severe Hemophilia
NCT05662319Hemophilia
DrugsAntithrombin·Clotting factor concentrates·Fitusiran
Sanofi
Phase 3
91
California, Minnesota, New Jersey, New York, Ohio, Pennsylvania, Texas
2023-02-01
Recruiting
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
NCT06311708Arrhythmogenic Right Ventricular Cardiomyopathy
Tenaya Therapeutics
Observational
200
California, Colorado, Maryland, Massachusetts, Minnesota, New York, Ohio, South Carolina
2023-01-31
Active, closed
Open-Label Extension Study of DCCR in Patients With Prader-Willi Syndrome
NCT05701774Prader-Willi Syndrome
Soleno Therapeutics, Inc.
Phase 3
83
California, Florida, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2023-01-31
Recruiting
MYLUNG Consortium Part 3: Observational Study
NCT05885698Carcinoma, Non-Small-Cell Lung
US Oncology Research
Observational
7,500
Alabama, Arizona, Colorado, Florida, Illinois, Maryland, Minnesota, New York
2023-01-30
Recruiting
A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
NCT04782258Autosomal Recessive Polycystic Kidney (ARPKD)
DrugTolvaptan
Otsuka Pharmaceutical Development & Commercialization, Inc.
Phase 3
20
District of Columbia, Georgia, Illinois, Indiana, Louisiana, Maryland, Michigan, Minnesota
2023-01-23
Active, closed
A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy
NCT05405361Multifocal Motor Neuropathy (MMN)
DrugEmpasiprubart
argenx
Phase 2
51
Arizona, Illinois, Minnesota, Ohio, Pennsylvania, Texas
2023-01-18
Active, closed
SKB264 in Combination With Pembrolizumab in Subjects With Selected Solid Tumors
NCT05642780Solid Tumor
DrugsSacituzumab tirumotecan·Keytruda·Pembrolizumab
Klus Pharma Inc.
Phase 2
240
Indiana, Kentucky, Maryland, Minnesota, New York, Texas, Virginia
2023-01-17
Active, closed
A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus
NCT05620407Systemic Lupus Erythematosus
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
513
California, Florida, Georgia, Illinois, Louisiana, Massachusetts, Michigan, Minnesota
2023-01-12
Active, closed
Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
NCT05526560Mitral Stenosis, Mitral Valve Insufficiency
Edwards Lifesciences
Observational
504
California, Florida, Georgia, Indiana, Michigan, Minnesota, Missouri, New York
2023-01-11
Active, closed
A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
NCT05552976Relapsed or Refractory Multiple Myeloma
DrugsMezigdomide·Carfilzomib·Dexamethasone
Bristol-Myers Squibb
Phase 3
606
Alabama, California, Florida, Georgia, Idaho, Maryland, Massachusetts, Minnesota
2023-01-10
Active, closed
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
NCT05680818Autosomal Dominant Hypocalcemia (ADH)
DrugEncaleret
Calcilytix Therapeutics, Inc., a BridgeBio company
Phase 3
67
California, Colorado, Indiana, Maryland, Massachusetts, Minnesota, New York, North Carolina
2023-01-06
Recruiting
Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™
NCT05853783Mouth Diseases
Proteocyte Diagnostics Inc.
Observational
180
Alabama, California, Minnesota, Texas
2023-01-01
Active, closed
A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia
NCT05648968Warm Autoimmune Hemolytic Anemia (wAIHA)
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
90
Michigan, Minnesota, Washington
2022-12-30
Active, closed
Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)
NCT05024773Bladder Carcinoma in Situ (CIS)
Fidia Farmaceutici s.p.a.
Phase 3
130
Arizona, Louisiana, Maryland, Minnesota, Ohio, South Carolina
2022-12-29
Active, closed
ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer
NCT05446298Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
DrugsGotistobart·Keytruda·Pembrolizumab
OncoC4, Inc.
Phase 2
58
Arizona, Connecticut, Florida, Illinois, Indiana, Kentucky, Louisiana, Minnesota
2022-12-22
Recruiting
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
NCT05549297Advanced Melanoma
DrugTebentafusp
Immunocore Ltd
Phase 3
540
Arizona, Florida, Georgia, Kansas, Kentucky, Massachusetts, Minnesota, Missouri
2022-12-19
Recruiting
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
NCT05650229Primary Mitochondrial Disease
DrugNapazimone
Pharming Technologies B.V.
Phase 2
180
California, Colorado, Connecticut, Florida, Georgia, Indiana, Maryland, Minnesota
2022-12-13
Active, closed
A Phase 1/2 Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Glanzmann Thrombasthenia
NCT06211634Glanzmann Thrombasthenia
Hemab ApS
Phase 1/2
57
California, Louisiana, Minnesota, Pennsylvania, Washington
2022-12-13
Active, closed
ACT-MBC: A Study of Circulating Tumor Cells (CTCs) in Metastatic Breast Cancer (MBC)
NCT05662345Metastatic Breast Cancer
Menarini Silicon Biosystems, INC
Observational
65
Minnesota, Wisconsin
2022-12-12
Active, closed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)
NCT06847854Diabetic Macular Edema
Genentech, Inc.
Phase 1
151
Arizona, Arkansas, California, Florida, Maryland, Michigan, Minnesota, Mississippi
2022-12-08
Active, closed
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
NCT05609578Advanced NSCLC, Metastatic Lung Cancer
DrugAdagrasib
Mirati Therapeutics Inc.
Phase 2
90
California, Colorado, Florida, Illinois, Kansas, Massachusetts, Michigan, Minnesota
2022-11-22
Active, closed
A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)
NCT05456191Philadelphia Chromosome-Positive Chronic Myeloid Leukemia
DrugsAsciminib·ABL001·Nilotinib
Novartis Pharmaceuticals
Phase 3
568
Colorado, Illinois, Minnesota, North Carolina, Ohio, Oregon, Texas, Virginia
2022-11-21
Active, closed
Safety and Effectiveness of the TENEO 317 Model 2 (1.28 US) Excimer Laser for Laser In Situ Keratomileusis (LASIK) Surgery to Treat Hyperopia With or Without Astigmatism
NCT05264623Hyperopia
Bausch & Lomb Incorporated
Not applicable
140
California, Florida, Minnesota, Nebraska, New York, Pennsylvania, South Dakota, Texas
2022-11-15
Recruiting
A Study Evaluating the Safety and Pharmacokinetics of QTORIN Rapamycin 3.9% Anhydrous Gel in the Treatment of Adults With Pachyonychia Congenita
NCT05643872Pachyonychia Congenita
DrugPTX-022
Palvella Therapeutics, Inc.
Phase 3
45
Minnesota
2022-11-15
Active, closed
REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /
NCT05372679Uncontrolled Stage 2 Hypertension
SoniVie Inc.
Not applicable
25
Alabama, Arkansas, Connecticut, Illinois, Minnesota, New York, North Carolina, South Carolina
2022-11-11
Active, closed
A Phase 1/2a Study of IMM-1-104 in Participants With Advanced or Metastatic Solid Tumors
NCT05585320Advanced Solid Tumor, Pancreatic Adenocarcinoma, Malignant Melanoma (Cutaneous), Non-small Cell Lung Cancer (NSCLC)
DrugsModified FOLFIRINOX·Dabrafenib·Pembrolizumab
Immuneering Corporation
Phase 1/2
209
Arizona, California, Colorado, Florida, Illinois, Massachusetts, Minnesota, New York
2022-10-31
Active, closed
The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain
NCT05491915Cervicogenic Headache, Occipital Neuralgia
SPR Therapeutics, Inc.
Not applicable
50
California, Massachusetts, Minnesota, North Carolina, Texas, Utah
2022-10-24
Recruiting
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
NCT05253651Colorectal Neoplasms
DrugsTucatinib·Erbitux·Herceptin·Avastin
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
400
Arizona, California, Colorado, Florida, Georgia, Kansas, Kentucky, Minnesota
2022-10-24
Active, closed
A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma
NCT05535244Multiple Myeloma
DrugsCevostamab·Tocilizumab
Hoffmann-La Roche
Phase 1/2
90
Colorado, Florida, Maryland, Massachusetts, Minnesota, New York, Tennessee, Utah
2022-10-17
Active, closed
Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects
NCT05476497Peanut Allergy
Allergy Therapeutics
Phase 1
46
Arizona, Florida, Kansas, Massachusetts, Minnesota, Missouri, New York, Ohio
2022-10-17
Active, closed
A Study About the Natural History in Adults With BAG3 Dilated Cardiomyopathy (a Type of Heart Disease) (BAG3 DCM)
NCT05981092Cardiomyopathy, Dilated, Bcl-2 Anathogene-3 (BAG3) Dilated Cardiomyopathy (DCM)
Alexion Pharmaceuticals, Inc.
Observational
35
California, Colorado, Massachusetts, Minnesota, New York, Pennsylvania
2022-10-14
Active, closed
Study of RYZ101 in Combination With SoC in Subjects With SSTR+ ES-SCLC
NCT05595460SCLC,Extensive Stage
DrugsRYZ101·Etoposide·Atezolizumab·Carboplatin
RayzeBio, Inc.
Phase 1
21
California, Florida, Iowa, Kentucky, Michigan, Minnesota, Missouri, Nebraska
2022-10-10
Active, closed
A Study of NX-019 in Patients with Advanced, Epidermal Growth Factor Receptor (EGFR) Mutant Cancer
NCT05514496EGFR Mutation-Related Tumors
Nalo Therapeutics Inc.
Phase 1
258
California, Minnesota, Virginia
2022-10-05
Active, closed
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis
NCT05503264NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis
DrugSatralizumab
Hoffmann-La Roche
Phase 3
122
Alabama, California, Colorado, District of Columbia, Georgia, Maryland, Massachusetts, Minnesota
2022-09-27
Recruiting
Post-Market Study to Assess iTind Safety in Comparison to UroLift
NCT04757116Benign Prostatic Hyperplasia (BPH)
Olympus Corporation of the Americas
Not applicable
256
Arizona, California, Illinois, Louisiana, Minnesota, Nebraska, Nevada, New York
2022-09-26
Active, closed
Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Cutaneous Squamous Cell Carcinoma
NCT05323253Recurrent Squamous Cell Carcinoma
Alpha Tau Medical LTD.
Not applicable
86
Arizona, California, Florida, Georgia, Minnesota, New Jersey, New Mexico, New York
2022-09-21
Active, closed
The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)
NCT05540327Systemic Lupus Erythematosus
DrugEnpatoran
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Phase 2
379
California, Florida, Indiana, Michigan, Minnesota, Ohio, Tennessee
2022-09-16
Recruiting
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
NCT05519449Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, Castration Resistant Prostatic Cancer
DrugsJANX007·Darolutamide
Janux Therapeutics
Phase 1
272
Alabama, Arizona, California, Connecticut, Florida, Illinois, Maryland, Minnesota
2022-09-15
Active, closed
A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT05057494Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
DrugsAcalabrutinib·Obinutuzumab·Venetoclax
AstraZeneca
Phase 3
607
Arizona, California, Colorado, Florida, Massachusetts, Minnesota, Missouri, New York
2022-09-12
Active, closed
An Observational Study of the T3 Pro Dental Implant System
NCT05498662Tooth Loss
ZimVie
Observational
60
Louisiana, Minnesota
2022-09-08
Recruiting
Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial
NCT05334368Hypereosinophilic Syndrome
DrugDepemokimab
GlaxoSmithKline
Phase 3
109
California, Georgia, Massachusetts, Michigan, Minnesota, New York, Ohio, South Carolina
2022-09-06
Recruiting
TVMR With the INNOVALVE System Trial - Early Feasibility Study
NCT04919980Mitral Valve Regurgitation (Degenerative or Functional)
Edwards Lifesciences
Not applicable
85
California, Florida, Georgia, Illinois, Michigan, Minnesota, Missouri, New Jersey
2022-09-01
Active, closed
Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer
NCT05508906Metastatic Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Breast Cancer
DrugsPalazestrant·Atirmociclib·Alpelisib·Everolimus
Olema Pharmaceuticals, Inc.
Phase 1
190
Arizona, California, Colorado, Florida, Iowa, Massachusetts, Michigan, Minnesota
2022-08-31
Active, closed
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
NCT05456880Sickle Cell Disease
Beam Therapeutics Inc.
Phase 1/2
15
Alabama, Arizona, Florida, Georgia, Massachusetts, Michigan, Minnesota, Missouri
2022-08-30
Recruiting
Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors
NCT05394103Advanced Cancer, Metastatic Cancer
DrugsKeytruda·Pembrolizumab
Qurient Co., Ltd.
Phase 1/2
130
Arizona, California, Florida, Illinois, Minnesota, New Jersey, Texas
2022-08-30
Active, closed
Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia
NCT05445323Friedreich Ataxia, Cardiomyopathy, Secondary
Lexeo Therapeutics
Phase 1/2
8
California, Florida, Minnesota
2022-08-24
Recruiting
A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments
NCT05137054Multiple Myeloma
DrugsNirogacestat·Cevostamab·Fianlimab·Linvoseltamab
Regeneron Pharmaceuticals
Phase 1
317
California, Georgia, Indiana, Massachusetts, Michigan, Minnesota, New York, North Carolina
2022-08-17
Recruiting
A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors
NCT05377996Triple Negative Breast Cancer, Breast Cancer, Endometrial Cancer, Ovarian Cancer
Day One Biopharmaceuticals, Inc.
Phase 1/2
360
Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota
2022-08-15
Recruiting
Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
NCT05254171Pancreatic Cancer Metastatic, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Stage IV
DrugsAbraxane·Nab-paclitaxel·Gemcitabine
Panbela Therapeutics, Inc.
Phase 2/3
600
Arkansas, California, Connecticut, District of Columbia, Michigan, Minnesota, New York, Ohio
2022-08-08
Active, closed
A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
NCT05092347Chronic Kidney Disease (CKD)
DrugVonsetamig
Regeneron Pharmaceuticals
Phase 1/2
43
California, Connecticut, District of Columbia, Illinois, Maryland, Minnesota, New York, Pennsylvania
2022-08-02
Recruiting
A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II
NCT05462587Leukocyte Adhesion Deficiency
DrugL-Fucose
AUG Therapeutics
Phase 3
4
Minnesota
2022-07-28
Active, closed
Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
NCT05263934Eosinophilic Granulomatosis With Polyangiitis
DrugsDepemokimab·Mepolizumab
GlaxoSmithKline
Phase 3
163
Colorado, Florida, Minnesota, New York, North Carolina, Pennsylvania
2022-07-14
Recruiting
The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials
NCT05203172Solid Tumors
DrugsVemurafenib·Binimetinib·Encorafenib·Zirabev
Pfizer
Phase 4
210
Arizona, Georgia, Massachusetts, Minnesota, Missouri, New Jersey, New York, North Carolina
2022-07-05
Recruiting
A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C
NCT05163288Niemann-Pick Disease, Type C
DrugN-Acetyl-L-Leucine
IntraBio Inc
Phase 3
53
Minnesota
2022-06-30
Active, closed
A Trial to Assess the Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With PLD
NCT05281328Polycystic Liver Disease
DrugCAM2029
Camurus AB
Phase 2/3
71
Minnesota, New York, Pennsylvania, Texas, Virginia
2022-06-28
Active, closed
MiSight 1 Day Post-Approval Study for Effectiveness and Visual Symptoms
NCT05285553Myopia
CooperVision, Inc.
Not applicable
900
Alabama, California, Florida, Illinois, Indiana, Kansas, Massachusetts, Minnesota
2022-06-25
Active, closed
MOTUS Total Joint Replacement Investigational Device Exemption Study
NCT05438719Lumbar Spine Degeneration
3Spine
Not applicable
158
California, Colorado, Florida, Kentucky, Louisiana, Minnesota, New York, North Carolina
2022-06-23
Active, closed
Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age
NCT05422222Cystic Fibrosis
DrugVNZ/TEZ/D-IVA
Vertex Pharmaceuticals Incorporated
Phase 3
210
California, Colorado, Georgia, Illinois, Indiana, Massachusetts, Minnesota, Missouri
2022-06-21
Active, closed
A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
NCT04970901B-Cell Non-Hodgkin Lymphoma, Relapsed B-Cell Non-Hodgkin Lymphoma, Refractory B-Cell Non-Hodgkin Lymphoma
DrugsLoncastuximab Tesirine·Mosunetuzumab·Polatuzumab Vedotin·Glofitamab
ADC Therapeutics S.A.
Phase 1
154
California, Florida, Georgia, Iowa, Massachusetts, Minnesota, New York, Ohio
2022-06-17
Recruiting
BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL
NCT05370430Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma
PeproMene Bio, Inc.
Phase 1
36
California, Kansas, Minnesota, North Carolina, Washington
2022-06-13
Active, closed
Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome
NCT05382156Endogenous Cushing's Syndrome
DrugOsilodrostat
RECORDATI GROUP
Observational
206
Arizona, Georgia, Illinois, Indiana, Kentucky, Massachusetts, Michigan, Minnesota
2022-06-13
Recruiting
Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
NCT05433142Clear Cell Renal Cell Carcinoma
Xencor, Inc.
Phase 1
307
Arizona, California, Connecticut, Florida, Georgia, Illinois, Kentucky, Minnesota
2022-06-13
Recruiting
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
NCT05245500Mesothelioma, Non Small Cell Lung Cancer, Malignant Peripheral Nerve Sheath Tumors, Solid Tumor
DrugNavlimetostat
Bristol-Myers Squibb
Phase 1
336
Arizona, Colorado, Florida, Illinois, Massachusetts, Michigan, Minnesota, New Jersey
2022-06-09
Recruiting
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
NCT05320198Myelofibrosis; Anemia, Anemia, Myelofibrosis, Myelofibrosis Due to and Following Polycythemia Vera
DrugDISC-0974
Disc Medicine, Inc
Phase 1/2
150
Arizona, California, Colorado, Florida, Georgia, Michigan, Minnesota, Missouri
2022-06-06
Recruiting
Study of ORIC-944 in Patients With Metastatic Prostate Cancer
NCT05413421Metastatic Prostate Cancer
DrugsDarolutamide (Nubeqa)·Rinzimetostat·Apalutamide (Erleada)
ORIC Pharmaceuticals
Phase 1
275
Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Minnesota, New York
2022-06-01
Active, closed
A Study to Evaluate the Efficacy and Safety of Serplulimab in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer
NCT05353257Limited-Stage Small Cell Lung Cancer
DrugsCarboplatin/cisplatin-etoposide·Slulimumab·Serplulimab
Shanghai Henlius Biotech
Phase 3
511
California, Colorado, Connecticut, Florida, Kansas, Louisiana, Minnesota, Nevada
2022-05-17
Active, closed
Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab (Phase 1a) and Pegylated Liposomal Doxorubicin (Phase 1b) as Treatment for Ovarian Cancer.
NCT05271318Platinum-refractory Ovarian Carcinoma, Platinum-resistant Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma
DrugsTILT-123·Pegylated liposomal doxorubicin·Keytruda·Pembrolizumab
TILT Biotherapeutics Ltd.
Phase 1/2
29
Minnesota, New York
2022-05-17
Active, closed
A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets
NCT05308654Relapsed/Refractory Multiple Myeloma
DrugsABBV-453·Daratumumab·Lenalidomide·Dexamethasone
AbbVie
Phase 1
34
California, Florida, Louisiana, Maryland, Michigan, Minnesota, New York, North Carolina
2022-05-17
Recruiting
A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors
NCT05307705Breast Cancer
DrugsAnastrozole, Exemestane·Imlunestrant·Abemaciclib·Letrozole
Eli Lilly and Company
Phase 1
260
Arizona, California, Florida, Georgia, Massachusetts, Minnesota, Missouri, New York
2022-05-11
Active, closed
RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)
NCT05134012Coronary Artery Disease
MedTrace Pharma A/S
Phase 3
215
Iowa, Minnesota, Missouri, Pennsylvania, Texas, Virginia
2022-05-08
Recruiting
To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva
NCT05090891Fibrodysplasia Ossificans Progressiva (FOP)
Incyte Corporation
Phase 2
98
Minnesota, Pennsylvania
2022-05-05
Recruiting
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
Adela, Inc
Observational
7,000
California, Florida, Georgia, Indiana, Kentucky, Minnesota, Ohio, Oregon
2022-05-03
Active, closed
EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT)
NCT05444894Transfusion Dependent Beta Thalassemia, Hemoglobinopathies, Thalassemia Major, Thalassemia Intermedia
Editas Medicine, Inc.
Phase 1/2
9
California, Minnesota, New York, Ohio, Pennsylvania, Tennessee
2022-04-29
Recruiting
Cephea Early Feasibility Study
NCT05061004Mitral Regurgitation
Abbott Medical Devices
Not applicable
90
Arizona, California, Georgia, Illinois, Kansas, Michigan, Minnesota, New York
2022-04-28
Recruiting
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
NCT05219617Seizures, Lennox Gastaut Syndrome
SK Life Science, Inc.
Phase 3
252
California, Florida, Idaho, Kentucky, Louisiana, Maryland, Minnesota, Missouri
2022-04-28
Active, closed
Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
NCT05074810Non Small Cell Lung Cancer, KRAS Activating Mutation
DrugLumakras
Verastem, Inc.
Phase 1/2
153
Colorado, District of Columbia, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri
2022-04-12
Recruiting
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
NCT05267626Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma, Non-Small Cell Lung Cancer
DrugsAvelumab·Aldesleukin·Nivolumab
Aulos Bioscience, Inc.
Phase 1/2
159
Florida, Michigan, Minnesota, Missouri, North Carolina, Tennessee, Texas, Utah
2022-04-04
Active, closed
Precise Procedural and PCI Plan (P4)
NCT05253677Coronary Artery Disease
CoreAalst BV
Not applicable
1,090
California, Minnesota, New York
2022-04-01
Recruiting
Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)
NCT04895436Chronic Lymphocytic Leukemia (CLL)
DrugsVenclexta·Obinutuzumab·Venetoclax
AbbVie
Phase 2
75
California, Georgia, Iowa, Massachusetts, Michigan, Minnesota, Mississippi, New Jersey
2022-03-28
Active, closed
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
NCT05348577Prostate Cancer
DrugsCapivasertib·Docetaxel
AstraZeneca
Phase 3
1,035
Arizona, California, Colorado, Maryland, Minnesota, New Jersey, New York, Ohio
2022-03-25
Recruiting
OssDsign® Spine Registry Study ("Propel")
NCT05329129Degenerative Disc Disease, Spinal Stenosis
OssDsign
Observational
450
California, Connecticut, Florida, Georgia, Illinois, Kentucky, Maryland, Minnesota
2022-03-23
Recruiting
Physio-Anatomy Clinical Data Collection Study
NCT05312164Coronary Stenosis
Gentuity, LLC
Observational
150
California, Florida, Georgia, Massachusetts, Minnesota, Ohio
2022-03-14
Active, closed
A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
NCT05238883Gastric Cancer, Renal Cell Carcinoma, Melanoma, Sarcoma
DrugTislelizumab
HiFiBiO Therapeutics
Phase 1
72
Arizona, California, Florida, Minnesota, Missouri, Texas, Virginia
2022-03-10
Recruiting
Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
NCT05315700Solid Tumors
ORIC Pharmaceuticals
Phase 1/2
350
California, Connecticut, District of Columbia, Florida, Illinois, Massachusetts, Minnesota, New York
2022-03-10
Recruiting
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
NCT05091424Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
DrugsMosunetuzumab·Venclyxto·Venclexta·Tocilizumab
Hoffmann-La Roche
Phase 1
332
Minnesota, New York, Ohio, Texas, Utah
2022-03-07
Active, closed
177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer
NCT05204927Metastasis From Malignant Tumor of Prostate
DrugEnzalutamide
Curium US LLC
Phase 3
439
Arizona, California, Florida, Illinois, Maryland, Michigan, Minnesota, Missouri
2022-02-14
Active, closed
A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II (STARLIGHT)
NCT04573023Mucopolysaccharidosis II
DrugsIdursulfase·JR-141
JCR Pharmaceuticals Co., Ltd.
Phase 3
86
Arizona, California, Illinois, Minnesota, New York, North Carolina, Pennsylvania
2022-02-14
Recruiting
InSpace Accelerated Rehabilitation Study
NCT05329584Rotator Cuff Tears
Stryker Endoscopy
Not applicable
160
Arizona, Arkansas, Colorado, Florida, Georgia, Illinois, Minnesota, New York
2022-02-07
Active, closed
ADH1 and ADH2 Disease Monitoring Study (DMS)
NCT05227287Autosomal Dominant Hypocalcemia
Calcilytix Therapeutics, Inc., a BridgeBio company
Observational
95
California, Colorado, Florida, Indiana, Massachusetts, Minnesota, North Carolina, Ohio
2022-01-20
Recruiting
Pelvic Health Electrically Evoked Recording (PEER) 2 Study
NCT05200923Overactive Bladder, Fecal Incontinence, Urinary Retention
MedtronicNeuro
Not applicable
300
Indiana, Louisiana, Minnesota, Ohio, Texas
2022-01-18
Active, closed
Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures
NCT05067634Partial Epilepsy
SK Life Science, Inc.
Phase 3
140
Arizona, California, Connecticut, Georgia, Maryland, Minnesota, New Jersey, New York
2022-01-10
Recruiting
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
NCT05490888Cirrhosis, Liver, Liver Fibrosis, Ascites Hepatic
PharmaIN
Phase 1
74
Arizona, California, Louisiana, Minnesota, Ohio, Pennsylvania, Texas
2022-01-03
Active, closed
Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE
NCT04919226Neuroendocrine Tumors
DrugsFOLFOX (Folinic acid·Everolimus·Fluorouracil·Oxaliplatin
ITM Solucin GmbH
Phase 3
259
California, Colorado, Florida, Massachusetts, Minnesota, Missouri, New York, North Carolina
2021-12-21
Active, closed
Long - Term Follow Up of Sickle Cell Disease and Beta-thalassemia Subjects Previously Exposed to BIVV003 or ST-400.
NCT05145062Blood and Lymphatic Diseases
Sangamo Therapeutics
Observational
8
California, Georgia, Massachusetts, Michigan, Minnesota
2021-12-21
By invitation
Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD
NCT05210803Neovascular Age-Related Macular Degeneration (nAMD)
DrugsLucentis·Ranibizumab
AbbVie
Phase 2
116
Arizona, California, Georgia, Maryland, Massachusetts, Minnesota, Nevada, New Mexico
2021-12-20
Active, closed
A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT04819100Carcinoma, Non-Small-Cell Lung
DrugSelpercatinib
Eli Lilly and Company
Phase 3
152
California, Florida, Massachusetts, Minnesota, New York, Pennsylvania, Tennessee, Texas
2021-12-20
Active, closed
Study to Evaluate the Safety and Efficacy of Daily Subcutaneous Metreleptin Treatment in Subjects With PL
NCT05164341Partial Lipodystrophy
DrugMetreleptin
Chiesi Farmaceutici S.p.A.
Phase 3
69
Alabama, California, Florida, Georgia, Massachusetts, Michigan, Minnesota, Missouri
2021-12-17
Active, closed
CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
NCT05210283Colorectal Cancer
Exact Sciences Corporation
Observational
1,017
California, Florida, Illinois, Iowa, Kansas, Maryland, Minnesota, Missouri
2021-12-15
Active, closed
BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)
NCT04982393Primary Hyperoxaluria Type 1
Alnylam Pharmaceuticals
Observational
207
Arizona, District of Columbia, Massachusetts, Minnesota, Ohio, Pennsylvania, Texas
2021-12-13
Active, closed
Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma
NCT04910022Glioblastoma, Diffuse Glioma
DrugsNMS-03305293·Temozolomide
Nerviano Medical Sciences
Phase 1/2
150
Arizona, California, Florida, Massachusetts, Minnesota, New York, Texas, Utah
2021-12-01
Recruiting
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis
Blueprint Medicines Corporation
Phase 2/3
534
Alabama, California, Colorado, Georgia, Massachusetts, Michigan, Minnesota, New York
2021-11-30
Active, closed
Long-Chain Fatty Acid Oxidation Disorders In-Clinic Disease Monitoring Program
NCT04632953Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
Ultragenyx Pharmaceutical Inc
Observational
150
Arizona, California, Colorado, Florida, Georgia, Illinois, Massachusetts, Minnesota
2021-11-30
Recruiting
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
NCT05103683Advanced Solid Tumor, Ovarian Cancer, Endometrial Cancer, NSCLC
DrugTORL-1-23
TORL Biotherapeutics, LLC
Phase 1
90
California, Kentucky, Minnesota, New York, Ohio, Texas, Virginia
2021-11-17
Active, closed
A Study of Lu AF82422 in Participants With Multiple System Atrophy
NCT05104476Multiple System Atrophy
DrugAmlenetug
H. Lundbeck A/S
Phase 2
64
California, Colorado, Florida, Illinois, Massachusetts, Minnesota, Nebraska, New York
2021-11-16
Active, closed
Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures
NCT04851717Pediatric ALL
DrugRemimazolam
Acacia Pharma Ltd
Phase 2/3
100
California, Massachusetts, Minnesota, Pennsylvania, Texas
2021-11-15
Active, closed
A Study of NDI 1150-101 in Patients With Solid Tumors
NCT05128487Solid Tumor, Renal Cell Carcinoma (Kidney Cancer), Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma, Non-Small Cell Lung Cancer
DrugPembrolizumab
Nimbus Saturn, Inc.
Phase 1/2
106
Arizona, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Michigan, Minnesota
2021-11-05
Recruiting
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
NCT05005403Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Micro Satellite Stable Colorectal Cancer, Gastric/Esophageal Cancer
DrugsBudigalimab·Telisotuzumab Adizutecan·Bevacizumab
AbbVie
Phase 1
694
California, Illinois, Indiana, Kentucky, Michigan, Minnesota, Nebraska, North Carolina
2021-11-01
Recruiting
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
NCT04981119Solid Tumor, Adult, Colorectal Cancer, Non Small Cell Lung Cancer, Pancreatic Cancer
A2 Biotherapeutics Inc.
Observational
500
Arizona, California, Florida, Massachusetts, Minnesota, Missouri, New York, Ohio
2021-10-29
Active, closed
Pyrocarbon Clinical Follow-up Study
NCT05049993Osteoarthritis of the Shoulder, Avascular Necrosis, Traumatic Arthritis
Stryker Trauma and Extremities
Observational
76
Colorado, Florida, Louisiana, Maryland, Minnesota, Missouri, North Carolina, Oregon
2021-10-27
Recruiting
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma
NCT04989803Relapsed and/or Refractory B-cell Lymphoma
DrugsKITE-753·KITE-363·Fludarabine·Cyclophosphamide
Kite, A Gilead Company
Phase 1/2
247
Arizona, California, Florida, Georgia, Illinois, Kentucky, Maryland, Minnesota
2021-10-27
Active, closed
Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
NCT04988386Amyloid Cardiomyopathy, Transthyretin-Related
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 3
389
California, Colorado, Illinois, Maryland, Massachusetts, Minnesota, Missouri, New York
2021-10-27
Active, closed
Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
NCT05113251Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer
DrugsHerzuma·Perjeta·Herceptin·Adriamycin
AstraZeneca
Phase 3
927
Arkansas, California, Connecticut, Indiana, Kentucky, Louisiana, Minnesota, Nevada
2021-10-25
Active, closed
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
NCT05050942Gastro-enteropancreatic Neuroendocrine Tumor
DrugsCAM2029·Octreotide LAR
Camurus AB
Phase 3
332
Arizona, California, Colorado, Florida, Kentucky, Louisiana, Massachusetts, Minnesota
2021-10-22
Active, closed
Study of Vimseltinib for Tenosynovial Giant Cell Tumor
NCT05059262Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse
DrugVimseltinib
Deciphera Pharmaceuticals, LLC
Phase 3
123
California, Colorado, Kansas, Massachusetts, Minnesota, New York, North Carolina, Ohio
2021-10-14
Active, closed
A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies
NCT05688436Multiple Sclerosis
DrugsDiroximel Fumarate·Plegridy·Ponesimod·Siponimod
Biogen
Observational
1,178
Minnesota
2021-09-24
Active, closed
Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to Treat Lymphoma
NCT04884035Lymphoma, B-Cell
DrugsGolcadomide·Iberdomide·Polatuzumab Vedotin·Prednisolone
Celgene
Phase 1
224
Alabama, Arizona, California, Florida, Georgia, Kansas, Minnesota, Nebraska
2021-09-15
Active, closed
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
NCT04909801Rheumatoid Arthritis
DrugsAbatacept·Humira·Adalimumab·Methotrexate
Bristol-Myers Squibb
Phase 3
338
California, Colorado, Maryland, Minnesota, New Jersey, New York, North Carolina, Oregon
2021-09-15
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors
NCT04774718ALK Fusion-positive Solid or CNS Tumors
DrugAlectinib
Hoffmann-La Roche
Phase 1/2
42
California, Florida, Michigan, Minnesota, New York, Ohio, Tennessee
2021-09-14
Active, closed
A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC
NCT04995523Non-Small-Cell Lung Carcinoma
DrugRilvegostomig
AstraZeneca
Phase 1/2
212
Illinois, Minnesota, Virginia
2021-09-14
Recruiting
Helix Research Network
NCT06057181Genetic Predisposition to Disease, Genetics Disease
Helix, Inc
Observational
2,000,000
Indiana, Minnesota, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania
2021-09-13
Recruiting
Perform Humeral System Study
NCT05067543Osteoarthritis Shoulder, Avascular Necrosis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Tear Arthropathy
Stryker Trauma and Extremities
Observational
300
Kentucky, Minnesota, Missouri, Ohio, South Dakota, Utah
2021-09-12
Active, closed
Clinical Study for Treatment-naïve IOPD Babies to Evaluate Efficacy and Safety of ERT With Avalglucosidase Alfa
NCT04910776Glycogen Storage Disease Type II
DrugAvalglucosidase alfa
Sanofi
Phase 3
17
California, Minnesota, New York, North Carolina, Ohio, Washington
2021-09-01
Active, closed
Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC
NCT04919811Non Small Cell Lung Cancer
DrugTaletrectinib
Nuvation Bio Inc.
Phase 2
217
California, Florida, Louisiana, Minnesota, New Jersey, Ohio, Tennessee, Texas
2021-09-01
Active, closed
MElanoma Research Lymph Node Prediction Implementation National_001
NCT04759781Melanoma
SkylineDx
Observational
1,820
Florida, Georgia, Kentucky, Michigan, Minnesota, New York, North Carolina, Utah
2021-08-25
Active, closed
Predictive Multimodal Signatures Associated With Response to Treatment and Prognosis of Patients With Stage IV Non-small Cell Lung Cancer
NCT04994795Non-small Cell Lung Cancer Metastatic
Sophia Genetics SAS
Observational
4,000
Iowa, Massachusetts, Minnesota, New York, Utah, Wisconsin
2021-08-21
Active, closed
Long-Term Follow-up of Subjects Who Were Treated With ST-920
NCT05039866Fabry Disease, Fabry Disease, Cardiac Variant
Sangamo Therapeutics
Observational
32
California, Florida, Georgia, Iowa, Minnesota, New York, Ohio, Virginia
2021-08-16
Recruiting
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
NCT05003986Focal Segmental Glomerulosclerosis, Minimal Change Disease, Immunoglobulin A Nephropathy, IgA Vasculitis
DrugSparsentan
Travere Therapeutics, Inc.
Phase 2
67
California, Delaware, Florida, Iowa, Massachusetts, Michigan, Minnesota, Missouri
2021-08-12
Recruiting
64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE)
NCT04868604Prostatic Neoplasms, Castration-Resistant
Drug64Cu-SAR-bisPSMA
Clarity Pharmaceuticals Ltd
Phase 1/2
54
California, Louisiana, Michigan, Minnesota, Missouri, Nebraska, New York
2021-08-11
Active, closed
Evaluating the Clinical Effectiveness of a Patient-specific Silicone Stent
NCT05050591Pulmonary Disease, Chronic Obstructive
VisionAir Solutions
Not applicable
20
Minnesota, Ohio
2021-08-05
Recruiting
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
NCT04913285Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
Pierre Fabre Medicament
Phase 1
400
California, Colorado, Florida, Minnesota, New Jersey, New York, Ohio, Tennessee
2021-08-04
Recruiting
A Study of 177Lu-FAP-2286 in Advanced Solid Tumors
NCT04939610Solid Tumor
Drug177Lu-FAP-2286
Novartis Pharmaceuticals
Phase 1/2
222
Alabama, California, Florida, Illinois, Iowa, Michigan, Minnesota, Missouri
2021-07-30
Recruiting
Zimmer Biomet Shoulder Arthroplasty PMCF
NCT04984291Shoulder Fractures, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Deformity
Zimmer Biomet
Not applicable
584
California, Colorado, Illinois, Kentucky, Michigan, Minnesota, Mississippi, Missouri
2021-07-28
Active, closed
EFS of the CardioMech MVRS
NCT04820764Mitral Regurgitation
CardioMech AS
Not applicable
35
California, Illinois, Kansas, Minnesota, New York, North Carolina, Ohio, Tennessee
2021-07-27
Active, closed
Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas
NCT05101148Neurofibromatosis Type 1
DrugSelumetinib
AstraZeneca
Phase 1
24
Minnesota, Ohio
2021-07-21
Active, closed
Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing
NCT04798768Tachycardia, Ventricular, Arrhythmia, Ventricular
Boston Scientific Corporation
Not applicable
297
Arizona, Arkansas, Florida, Georgia, Kentucky, Minnesota, New Jersey, New York
2021-07-20
Active, closed
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment
NCT04908189Psoriatic Arthritis
DrugsApremilast·Deucravacitinib
Bristol-Myers Squibb
Phase 3
729
Alabama, California, Illinois, Kentucky, Louisiana, Maryland, Michigan, Minnesota
2021-07-15
Active, closed
A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases
NCT04554914Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
DrugTabelecleucel
Pierre Fabre Medicament
Phase 2
190
California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, Minnesota
2021-07-14
Active, closed
Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.
NCT05018286Short Bowel Syndrome
DrugApraglutide
VectivBio AG
Phase 3
158
California, Florida, Illinois, Michigan, Minnesota, Nebraska, New York, North Carolina
2021-07-13
Active, closed
FT819 in Subjects With B-cell Malignancies
NCT04629729Lymphoma, B-Cell, Chronic Lymphocytic Leukemia, Precursor B-Cell Acute Lymphoblastic Leukemia
DrugsFT819·Fludara·Aldesleukin·Bendamustine
Fate Therapeutics
Phase 1
54
Alabama, Arizona, California, Florida, Iowa, Kansas, Kentucky, Minnesota
2021-07-12
Recruiting
A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma
NCT04669171Follicular Lymphoma, Marginal Zone Lymphoma
DrugsLenalidomide·Rituximab
Enterome
Phase 1/2
80
Massachusetts, Minnesota, New York, Washington
2021-07-05
Active, closed
A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH)
NCT04783181Congenital Adrenal Hyperplasia
Adrenas Therapeutics Inc
Phase 1/2
8
Illinois, Maryland, Minnesota, North Carolina, Pennsylvania
2021-07-01
Active, closed
Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
NCT04411654Gaucher Disease, Type 2
DrugsSirolimus·Methylprednisolone·Prednisone
Prevail Therapeutics
Phase 1/2
7
California, Minnesota, New York, Pennsylvania, Virginia
2021-06-29
Active, closed
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
NCT04629248Primary Membranous Nephropathy
DrugsDiphenhydramine·Acetaminophen·Tacrolimus·Methylprednisolone
Hoffmann-La Roche
Phase 3
142
California, Colorado, Florida, Iowa, Michigan, Minnesota, New York, Texas
2021-06-25
Recruiting
Persona Revision Knee System Outcomes
NCT04821154Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis
Zimmer Biomet
Observational
380
Arkansas, California, Colorado, Indiana, Kentucky, Michigan, Minnesota, Missouri
2021-06-14
Active, closed
da Vinci SP® Investigational Device Exemption Study in Colorectal Procedures
NCT04403022Colorectal Cancer, Benign or Malignant Rectal or Colon Tumors
Intuitive Surgical
Not applicable
60
Florida, Michigan, Minnesota, Nevada, Pennsylvania, Texas, Washington
2021-06-03
Active, closed
Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)
NCT04703192Relapsed/Refractory Peripheral T-Cell Lymphoma, Adult T Cell Leukemia/Lymphoma
DrugValemetostat Tosylate
Daiichi Sankyo
Phase 2
155
California, Colorado, Georgia, Illinois, Massachusetts, Minnesota, Missouri, New Jersey
2021-06-03
Active, closed
3Spine Lumbar Fusion Real World Evidence Study
NCT04823858Lumbar Spine Degeneration
3Spine
Observational
176
California, Colorado, Florida, Kentucky, Louisiana, Minnesota, New York, North Carolina
2021-05-25
Active, closed
Once Daily Versus Twice Daily Budesonide Orodispersible Tablets for Induction of Remission in EoE
NCT06596252Eosinophilic Esophagitis
DrugBudesonide
Dr. Falk Pharma GmbH
Phase 3
308
Arizona, Arkansas, California, Florida, Idaho, Massachusetts, Michigan, Minnesota
2021-05-21
Recruiting
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
NCT04614103Metastatic Non Small Cell Lung Cancer
Iovance Biotherapeutics, Inc.
Phase 2
170
Arizona, Florida, Illinois, Kentucky, Maryland, Michigan, Minnesota, Nebraska
2021-05-07
Recruiting
Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors
NCT04855656Advanced Solid Tumor
DrugsCamonsertib·Lunresertib
Debiopharm International SA
Phase 1
464
California, Connecticut, Florida, Massachusetts, Michigan, Minnesota, Missouri, New York
2021-04-30
Active, closed
Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma
NCT04756726Multiple Myeloma, Lymphoma, Non-Hodgkin's
DrugsCemsidomide·Dexamethasone
C4 Therapeutics, Inc.
Phase 1
224
Arizona, California, Colorado, Florida, Georgia, Massachusetts, Minnesota, Missouri
2021-04-27
Recruiting
ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)
NCT04883905Acute Hepatic Porphyria
Alnylam Pharmaceuticals
Observational
150
Alabama, Arizona, California, Maryland, Massachusetts, Minnesota, New York, North Carolina
2021-04-26
Recruiting
Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD
NCT04580420Primary Hyperoxaluria Type 1, End Stage Renal Disease
DrugDcr-Phxc
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Phase 2
28
California, Massachusetts, Minnesota, New York
2021-04-15
Active, closed
COMPASSION S3 Post-Approval Study
NCT04860765Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration
Edwards Lifesciences
Observational
150
Alabama, California, Colorado, Illinois, Massachusetts, Minnesota, Missouri, New Jersey
2021-04-13
Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
DrugNemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
490
Arkansas, California, Colorado, Kentucky, Minnesota, New Jersey, North Dakota, Texas
2021-04-05
Active, closed
Robotic-Assisted da Vinci System Prophylactic Nipple-Sparing Mastectomy
NCT03892980Nipple Sparing Mastectomy
Intuitive Surgical
Not applicable
145
Florida, Illinois, Minnesota, New York, Pennsylvania, Texas
2021-03-26
Recruiting
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
NCT04665206Solid Tumor, Adult, Mesothelioma, NSCLC
DrugsPemetrexed/Carboplatin·Osimertinib·Ipilimumab
Vivace Therapeutics, Inc
Phase 1/2
434
California, Illinois, Massachusetts, Minnesota, New York, Texas, Virginia
2021-03-24
Active, closed
Study of Safety, Tolerability and Efficacy of PBGM01 in Pediatric Participants With GM1 Gangliosidosis
NCT04713475GM1 Gangliosidosis, GM1 Gangliosidosis, Type I, GM1 Gangliosidosis, Type 2, Beta-Galactosidase-1 (GLB1) Deficiency
Gemma Biotherapeutics
Phase 1/2
26
California, Minnesota, New Jersey, Pennsylvania
2021-03-17
Active, closed
A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Multiple Sclerosis and Their Infants
NCT06133049Multiple Sclerosis
DrugOzanimod
Bristol-Myers Squibb
Observational
2,961
Minnesota
2021-03-16
Recruiting
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Aria CV, Inc
Not applicable
30
California, Indiana, Massachusetts, Minnesota, New York, Ohio, South Carolina, Wisconsin
2021-03-15
Active, closed
Atrasentan in Patients With Proteinuric Glomerular Diseases
NCT04573920IgA Nephropathy, Focal Segmental Glomerulosclerosis, Alport Syndrome, Diabetic Kidney Disease
DrugAtrasentan
Novartis Pharmaceuticals
Phase 2
103
California, Colorado, Louisiana, Massachusetts, Minnesota, Nevada, North Carolina, Texas
2021-03-15
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
DrugAutogene cevumeran
BioNTech SE
Phase 2
327
California, Indiana, Minnesota, Ohio, Rhode Island, Tennessee, Texas, Virginia
2021-03-08
Active, closed
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
NCT04775082Obesity
DrugLiraglutide
Novo Nordisk A/S
Phase 3
78
Arizona, Colorado, Idaho, Louisiana, Maryland, Minnesota, New York, Ohio
2021-03-04
Active, closed
Immunogenicity, Safety, Reactogenicity and Persistence of an Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above
NCT04732871Respiratory Syncytial Virus Infections
GlaxoSmithKline
Phase 3
1,720
Alabama, Arizona, California, Florida, Indiana, Kansas, Minnesota, Missouri
2021-02-15
Active, closed
A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)
NCT04628494Diffuse Large B-cell Lymphoma
DrugEpcoritamab
Genmab
Phase 3
483
Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas
2021-01-13
Active, closed
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
NCT04579380Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms
DrugsTucatinib·Herceptin·Fulvestrant·Trastuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 2
217
Arizona, California, Colorado, Florida, Minnesota, Missouri, Nebraska, New York
2021-01-11
Active, closed
MYLUNG Consortium Study Protocol 2
NCT05644808Carcinoma, Non-Small-Cell Lung
US Oncology Research
Observational
1,002
Alabama, Colorado, Florida, Illinois, Maryland, Minnesota, New York, Ohio
2020-12-29
Active, closed
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
NCT04607421Neoplasms
DrugsEncorafenib·Zirabev·Erbitux·Xeloda
Pfizer
Phase 3
841
Arizona, California, Florida, Illinois, Louisiana, Minnesota, Missouri, Nebraska
2020-12-21
Active, closed
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
NCT04305795Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head-and-neck Squamous-cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
DrugsCemiplimab·Pembrolizumab
Rakuten Medical, Inc.
Phase 1/2
23
Florida, Kentucky, Minnesota, Oregon, Pennsylvania, Tennessee, Texas
2020-12-21
Active, closed
A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation
NCT04625270Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer
DrugsAvutometinib (VS-6766) and defactinib·Avutometinib·Lumakras
Verastem, Inc.
Phase 2
225
Arizona, California, Connecticut, Florida, Illinois, Maryland, Minnesota, Missouri
2020-12-21
Active, closed
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
NCT04171492Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Biodesix, Inc.
Observational
2,000
Colorado, Connecticut, District of Columbia, Indiana, Maryland, Michigan, Minnesota, Missouri
2020-12-18
Active, closed
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
NCT04663308Primary Sclerosing Cholangitis
DrugVolixibat
Mirum Pharmaceuticals, Inc.
Phase 2
182
California, Colorado, District of Columbia, Florida, Massachusetts, Michigan, Minnesota, Mississippi
2020-12-18
Active, closed
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
NCT04490915Congenital Adrenal Hyperplasia
DrugCrinecerfont
Neurocrine Biosciences
Phase 3
182
California, Colorado, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2020-12-16
Active, closed
Beating Heart Mitral Valve Repair With the HARPOON™ System
NCT04375332Mitral Regurgitation
Edwards Lifesciences
Not applicable
25
California, Georgia, Maryland, Michigan, Minnesota, Oregon, Tennessee, Utah
2020-12-16
Active, closed
A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04586426Multiple Myeloma
DrugsTalquetamab·Teclistamab
Janssen Research & Development, LLC
Phase 1/2
228
Alabama, Arkansas, Colorado, Georgia, Minnesota, Missouri, New York, North Carolina
2020-12-15
Active, closed
PARADIGM: Amplatzer Valvular Plug for PVL Closure
NCT04489823Paravalvular Aortic Regurgitation
Abbott Medical Devices
Not applicable
200
Alabama, Georgia, Massachusetts, Minnesota, Missouri, Nebraska, New Jersey, New York
2020-12-01
By invitation
Adherus™ Dural Sealant in Spinal Procedures
NCT04498026Spinal Duraplasty
Stryker Craniomaxillofacial
Not applicable
114
California, Florida, Illinois, Minnesota, New York, North Carolina, Pennsylvania, Texas
2020-11-19
Active, closed
IN.PACT™ AV Access Post-Approval Study (PAS002)
NCT04543539Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Fistula
Medtronic
Observational
240
California, Connecticut, District of Columbia, Florida, Iowa, Michigan, Minnesota, New Jersey
2020-11-13
Active, closed
A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer
NCT04644770Prostatic Neoplasms, Adenocarcinoma
DrugPasritamig
Janssen Research & Development, LLC
Phase 1
144
Arizona, California, Florida, Illinois, Louisiana, Minnesota, Nebraska, New York
2020-11-12
Active, closed
Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma
NCT04417621Melanoma
DrugsNaporafenib·Trametinib·Ribociclib
Novartis Pharmaceuticals
Phase 2
134
California, Florida, Massachusetts, Minnesota, New York, Pennsylvania, Texas
2020-10-30
Recruiting
The Tether™ - Vertebral Body Tethering System Post Approval Study
NCT04505579Scoliosis Idiopathic
ZimVie
Observational
200
California, Colorado, Florida, Georgia, Louisiana, Minnesota, Missouri, New York
2020-10-29
Active, closed
Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers
NCT04404595Gastric Cancer, Pancreatic Cancer
CARsgen Therapeutics Co., Ltd.
Phase 1/2
110
California, Florida, Kansas, Michigan, Minnesota, New York, Ohio, Texas
2020-10-23
By invitation
Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy
NCT04628585Sickle Cell Disease
Genetix Biotherapeutics Inc.
Observational
85
Alabama, California, Georgia, Illinois, Maryland, Minnesota, New Jersey, New York
2020-10-21
Active, closed
TTVR Early Feasibility Study
NCT04433065Tricuspid Regurgitation
Medtronic Cardiovascular
Not applicable
150
Alabama, Arizona, California, Connecticut, Georgia, Michigan, Minnesota, Montana
2020-10-20
Active, closed
CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC
NCT04495153Non Small Cell Lung Cancer
DrugAglatimagene besadenovec
Candel Therapeutics, Inc.
Phase 2
90
Arizona, Connecticut, Illinois, Maryland, Minnesota, New York, Ohio, Pennsylvania
2020-10-13
Active, closed
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
NCT04590963Squamous Cell Carcinoma of the Head and Neck
DrugsMonalizumab·Erbitux·Cetuximab
AstraZeneca
Phase 3
370
Arizona, Illinois, Kansas, Massachusetts, Michigan, Minnesota, Missouri, Nevada
2020-10-02
Active, closed
Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations
NCT04521686Cholangiocarcinoma, Chondrosarcoma, Glioma, Any Solid Tumor
DrugsLY3410738·Durvalumab·Gemcitabine·Cisplatin
Eli Lilly and Company
Phase 1
200
Arizona, California, Florida, Illinois, Indiana, Maryland, Massachusetts, Minnesota
2020-10-01
Active, closed
A Gene Transfer Study for Late-Onset Pompe Disease (RESOLUTE)
NCT04093349Pompe Disease, Pompe Disease (Late-onset), Glycogen Storage Disease Type 2, Glycogen Storage Disease Type II
Spark Therapeutics, Inc.
Phase 1/2
4
Arizona, California, Georgia, Kansas, Minnesota, Oregon, Pennsylvania, Utah
2020-10-01
Active, closed
Open Nipple Sparing Mastectomy (NSM)
NCT04447339Nipple Sparing Mastectomy
Intuitive Surgical
Observational
75
Illinois, Minnesota, New York, Pennsylvania, Texas
2020-09-21
Active, closed
Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)
NCT04526691Advanced or Metastatic NSCLC
DrugsDato-DXd·Keytruda·Cisplatin·Carboplatin
Daiichi Sankyo
Phase 1
145
Arizona, California, District of Columbia, Florida, Maryland, Minnesota, New Mexico, Texas
2020-09-15
Recruiting
Evaluate the Safety and Clinical Activity of HH2853
NCT04390737FL Lymphoma, Epithelioid Sarcoma, Peripheral T Cell Lymphoma, Advanced Solid Tumor
DrugHH2853
Haihe Biopharma Co., Ltd.
Phase 1/2
254
Arizona, Florida, Minnesota, Texas
2020-09-08
Recruiting
Hydrus® Microstent New Enrollment Post-Approval Study
NCT04553523Primary Open Angle Glaucoma
Alcon Research
Not applicable
545
California, Colorado, Iowa, Kansas, Maryland, Michigan, Minnesota, Missouri
2020-08-25
Active, closed
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)
NCT04504825AL Amyloidosis
DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)
Alexion Pharmaceuticals, Inc.
Phase 3
125
California, Florida, Indiana, Louisiana, Massachusetts, Michigan, Minnesota, Missouri
2020-08-25
Active, closed
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib
NCT04421963Ovarian Cancer, Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
185
Florida, Maryland, Michigan, Minnesota, New Jersey, New York, Pennsylvania, Rhode Island
2020-08-04
Active, closed
Gene Therapy for Fanconi Anemia, Complementation Group A
NCT04248439Fanconi Anemia Complementation Group A
DrugRP-L102
Rocket Pharmaceuticals Inc.
Phase 2
5
California, Minnesota
2020-07-15
Recruiting
An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
NCT04029337Mitral Regurgitation
HighLife SAS
Not applicable
30
Arizona, California, Georgia, Massachusetts, Minnesota, New York, Pennsylvania, South Carolina
2020-07-14
Recruiting
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
NCT04219254Solid Tumor, Adult
DrugKeytruda
BioInvent International AB
Phase 1/2
197
California, Colorado, Minnesota, Oklahoma, Texas
2020-06-29
Active, closed
A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.
NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma
DrugTazemetostat
Epizyme, Inc.
Phase 3
599
Alabama, Arizona, California, Colorado, Florida, Illinois, Michigan, Minnesota
2020-06-11
Active, closed
A Study of FCX-007 for Recessive Dystrophic Epidermolysis Bullosa
NCT04213261Recessive Dystrophic Epidermolysis Bullosa
Castle Creek Biosciences, LLC.
Phase 3
6
California, Colorado, Florida, Minnesota, Texas
2020-06-09
Active, closed
Post-approval Registry Study to Evaluate the Continued Safety and Probable Benefit of the MID-C System for 5 Years Post-Implantation in Adolescent Idiopathic Scoliosis (AIS)
NCT04296903Adolescent Idiopathic Scoliosis
Apifix
Not applicable
201
California, Florida, Georgia, Indiana, Kansas, Minnesota, Mississippi, Missouri
2020-05-31
Active, closed
Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS
NCT04057898Amyotrophic Lateral Sclerosis
MediciNova
Phase 2/3
234
California, Florida, Georgia, Indiana, Maryland, Minnesota, New York, North Carolina
2020-05-28
Active, closed
Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies
NCT04349436Merkel Cell Carcinoma, Basal Cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Cancer
Replimune, Inc.
Phase 1/2
69
Arizona, California, Colorado, Florida, Massachusetts, Minnesota, Missouri, New York
2020-05-15
Active, closed
Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients
NCT04291105Melanoma, Head and Neck Squamous Cell Carcinoma, Colo-rectal Cancer
DrugsVSV-IFNβ-NIS·Cemiplimab
Vyriad, Inc.
Phase 2
87
California, Connecticut, Florida, Louisiana, Minnesota, Montana, New York, Ohio
2020-04-24
Active, closed
Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer
NCT04305496Locally Advanced (Inoperable) or Metastatic Breast Cancer
DrugsCapivasertib·Fulvestrant
AstraZeneca
Phase 3
818
Arizona, California, Florida, Kansas, Maryland, Massachusetts, Minnesota, Missouri
2020-04-16
Active, closed
Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies
NCT04277637Mature B-Cell Malignancies
DrugsSonrotoclax·Zanubrutinib·Obinutuzumab
BeOne Medicines
Phase 1
437
California, Illinois, Kansas, Massachusetts, Minnesota, Nebraska, New Jersey, New York
2020-03-24
Recruiting
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor
NCT04906434Advanced Liver Cancer
DrugABSK-011
Abbisko Therapeutics Co, Ltd
Phase 1
200
Arizona, Florida, Minnesota, New York, Texas
2020-02-26
Active, closed
A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Disease
NCT04293185Sickle Cell Disease
Genetix Biotherapeutics Inc.
Phase 3
35
Alabama, District of Columbia, Massachusetts, Minnesota, New Jersey, New York, North Carolina, Texas
2020-02-14
Active, closed
MitraClip EXPAND G4 Study
NCT04177394Mitral Valve Regurgitation, Mitral Regurgitation
Abbott Medical Devices
Observational
1,164
Alabama, Arkansas, California, Connecticut, Florida, Illinois, Kansas, Minnesota
2020-01-17
Active, closed
A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib
NCT04170283B-cell Malignancies
DrugsZanubrutinib·Tislelizumab
BeOne Medicines
Phase 3
955
Arizona, Arkansas, Colorado, Florida, Massachusetts, Michigan, Minnesota, Mississippi
2020-01-16
Active, closed
Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET
NCT03972488Gastro-enteropancreatic Neuroendocrine Tumor
DrugsOctreotide LAR·Lutathera
Advanced Accelerator Applications
Phase 3
226
Connecticut, Florida, Iowa, Kentucky, Minnesota, Texas
2020-01-08
Active, closed
Phase 1/2a Clinical Trial of PR001 (LY3884961) in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)
NCT04127578Parkinson Disease
DrugsSirolimus·Methylprednisolone
Prevail Therapeutics
Phase 1/2
32
Arizona, California, Colorado, Florida, Illinois, Minnesota, New York, Pennsylvania
2020-01-03
Active, closed
Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors
NCT03967223Neoplasms
DrugsFludarabine·Cyclophosphamide
USWM CT, LLC
Phase 2
103
California, Colorado, Florida, Illinois, Iowa, Massachusetts, Michigan, Minnesota
2019-12-31
Active, closed
Continued Access of Focal MR-Guided Focused Ultrasound for Localized Intermediate Risk Prostate Lesions
NCT03998657Prostate Cancer
InSightec
Not applicable
14
California, Florida, Massachusetts, Minnesota, New York
2019-12-19
Recruiting
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
NCT04198766Solid Tumor, Non-Small Cell Lung Cancer, Head and Neck Cancer, Melanoma
DrugsCarboplatin (AUC 5)·Carboplatin (AUC 6)·Nab-paclitaxel·Pemetrexed
Inhibrx Biosciences, Inc
Phase 1/2
340
California, Florida, Georgia, Illinois, Iowa, Kentucky, Michigan, Minnesota
2019-12-10
Active, closed
OCS DCD Heart + CAP Continued Follow-Up
NCT05741723Heart Transplant
TransMedics
Observational
276
California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts, Minnesota
2019-11-26
Active, closed
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
NCT04153149Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
DrugVutrisiran
Alnylam Pharmaceuticals
Phase 3
655
California, District of Columbia, Georgia, Illinois, Massachusetts, Minnesota, New York, North Carolina
2019-11-26
Active, closed
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
NCT04148391Mild Cognitive Impairment, Mild Dementia, Parkinson Disease, Lewy Body Disease
Aptinyx
Phase 2
99
Arizona, California, Florida, Georgia, Michigan, Minnesota, New Jersey, New York
2019-11-14
Active, closed
A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies
NCT03888105B-cell Non-Hodgkin Lymphoma (B-NHL)
DrugOdronextamab
Regeneron Pharmaceuticals
Phase 2
515
Illinois, Iowa, Kentucky, Massachusetts, Minnesota, New Jersey, New York, North Carolina
2019-11-13
Active, closed
IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia
NCT04086264Acute Myeloid Leukemia
DrugsIMGN632·Venclyxto·Decitabine·Venclexta
AbbVie
Phase 1/2
218
California, Florida, Illinois, Massachusetts, Michigan, Minnesota, New York, North Carolina
2019-11-06
Active, closed
Pediatric Long-Term Follow-up and Rollover Study
NCT03975829Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood
DrugsDabrafenib·Trametinib
Novartis Pharmaceuticals
Phase 4
163
Arizona, District of Columbia, Florida, Indiana, Maryland, Massachusetts, Minnesota, New York
2019-11-04
Active, closed
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
NCT04157348Eosinophilic Granulomatous Vasculitis
DrugsBenralizumab·Mepolizumab
AstraZeneca
Phase 3
140
Colorado, Michigan, Minnesota, New Mexico, New York, Pennsylvania, Texas, Washington
2019-10-29
Active, closed
Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A
NCT03932201Hemophilia A
DrugDamoctocog alfa pegol
Bayer
Observational
371
Alabama, Arizona, California, Colorado, District of Columbia, Louisiana, Minnesota, North Carolina
2019-10-21
Active, closed
Voyage: Real-World Impact of the Multi-target Stool DNA Test on CRC Screening and Mortality
NCT04124406Colon Cancer
Exact Sciences Corporation
Observational
150,000
Minnesota
2019-10-18
Recruiting
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
NCT03955445C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
225
Colorado, Georgia, Iowa, Minnesota, New York
2019-10-03
By invitation
A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)
NCT04093570Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes
DrugDecitabine
Taiho Oncology, Inc.
Phase 2
332
California, Florida, Illinois, Maryland, Michigan, Minnesota, New Jersey, New York
2019-09-30
Active, closed
A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
NCT03989414Multiple Myeloma
DrugsElotuzumab·Mezigdomide·Isatuximab·Carfilzomib
Celgene
Phase 1/2
424
Colorado, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota, New Jersey
2019-09-30
Active, closed
Clinical Trial to Evaluate Zevor-cel (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)
NCT03915184Multiple Myeloma
CARsgen Therapeutics Co., Ltd.
Phase 1/2
105
Arizona, California, Colorado, Florida, Massachusetts, Minnesota, Tennessee, Texas
2019-09-25
Active, closed
Portico Next Generation Approval Study
NCT04011722Symptomatic Severe Aortic Stenosis
Abbott Medical Devices
Not applicable
333
California, District of Columbia, Illinois, Indiana, Kansas, Michigan, Minnesota, New Jersey
2019-09-17
Active, closed
Alfapump® System in the Treatment of Refractory or Recurrent Ascites (POSEIDON Study)
NCT03973866Ascites
Sequana Medical N.V.
Not applicable
110
Arizona, California, Massachusetts, Minnesota, North Carolina, Pennsylvania, South Carolina, South Dakota
2019-09-16
Active, closed
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
NCT04067336Advanced Malignant Neoplasm, Acute Myeloid Leukemia, Mixed Lineage Leukemia, Mixed Lineage Acute Leukemia
DrugsZiftomenib·Itraconazole·Midazolam
Kura Oncology, Inc.
Phase 1/2
263
Arizona, California, Florida, Illinois, Maryland, Massachusetts, Michigan, Minnesota
2019-09-12
Recruiting
A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors
NCT03972657Metastatic Castration-Resistant Prostate Cancer (mCRPC), Clear Cell Renal Cell Carcinoma (ccRCC)
DrugsNezastomig·Cemiplimab
Regeneron Pharmaceuticals
Phase 1/2
345
Arizona, California, Colorado, Connecticut, Florida, Massachusetts, Michigan, Minnesota
2019-08-12
Active, closed
Long Term Extension Study in Patients With Primary Hyperoxaluria
NCT04042402Primary Hyperoxaluria Type 1 (PH1), Primary Hyperoxaluria Type 2 (PH2), Kidney Diseases, Urologic Diseases
DrugDcr-Phxc
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Phase 3
75
California, Massachusetts, Minnesota, New York
2019-07-09
Active, closed
A Research Study in Children Born Small and Who Stayed Small. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day
NCT03878446Short Stature Children Born Small for Gestational Age (SGA)
DrugsNorditropin·Somapacitan
Novo Nordisk A/S
Phase 2
62
Alabama, California, Idaho, Minnesota, New Jersey, New York, Ohio, Oklahoma
2019-07-04
Active, closed
A Study of TNB-383B in Participants With Relapsed or Refractory Multiple Myeloma
NCT03933735Multiple Myeloma
DrugEtentamig
AbbVie
Phase 1/2
220
California, Louisiana, Minnesota, Missouri, New York, North Carolina, Wisconsin
2019-06-24
Active, closed
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
NCT03899792Medullary Thyroid Cancer, Infantile Myofibromatosis, Infantile Fibrosarcoma, Papillary Thyroid Cancer
DrugSelpercatinib
Eli Lilly and Company
Phase 1/2
36
California, Colorado, Florida, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2019-06-13
Active, closed
SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab
NCT03161431Melanoma Stage III, Melanoma Stage IV
DrugsSX-682·Keytruda·Pembrolizumab
Syntrix Biosystems, Inc.
Phase 1
77
Florida, Massachusetts, Minnesota, New York, Texas
2019-06-12
Recruiting
Observational, Non-Interventional Study Supporting Validation of eVO2peak Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)
NCT05678530Cardiopulmonary
Prolaio
Observational
2,000
Arizona, California, Delaware, Florida, Illinois, Minnesota, Texas, Utah
2019-06-06
Recruiting
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
NCT03808922Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
Ansun Biopharma, Inc.
Phase 3
274
California, Illinois, Iowa, Kansas, Maryland, Massachusetts, Minnesota, Missouri
2019-05-23
Active, closed
Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
NCT03720782Total Knee Arthroplasty
Smith & Nephew, Inc.
Observational
118
Minnesota, Missouri
2019-05-22
Active, closed
Case-Control Study of the Glycotest™ HCC Panel vs AFP for the Detection of Early-stage Hepatocellular Carcinoma
NCT03878550Carcinoma, Hepatocellular, Cirrhosis, Liver
Glycotest, Inc.
Observational
766
California, Florida, Illinois, Maryland, Michigan, Minnesota, New York, Pennsylvania
2019-05-22
Recruiting
Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
NCT05181826Cancer, Liver Cirrhosis, Chronic Hepatitis, Hepatitis B
Helio Genomics
Observational
1,200
California, Minnesota, Tennessee, Texas
2019-05-21
Active, closed
PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS
NCT03927261Acute Myeloid Leukemia, Myelodysplastic Syndromes
Precigen, Inc
Phase 1
88
Florida, Minnesota
2019-05-20
Active, closed
A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)
NCT03930953Lymphoma, Non-Hodgkin
DrugsValemetostat·Tafasitamab·Golcadomide·Obinutuzumab
Celgene
Phase 1/2
438
Arizona, Florida, Kansas, Minnesota, Missouri, New Jersey, Texas
2019-05-20
Active, closed
A Registry Study of NanoKnife IRE for Stage 3 Pancreatic Cancer
NCT03899649Stage III Pancreatic Cancer
Angiodynamics, Inc.
Observational
532
California, Florida, Georgia, Illinois, Iowa, Kentucky, Minnesota, Missouri
2019-05-08
Active, closed
Ph I/II Trial of Systemic VSV-IFNβ-NIS in Combination With Checkpoint Inhibitor Therapy in Patients With Select Solid Tumors
NCT03647163Solid Tumor, Non Small Cell Lung Cancer, Neuroendocrine Carcinoma, Renal Cell Carcinoma (RCC)
DrugsVSV-IFNβ-NIS·Ipilimumab·Nivolumab·Pembrolizumab
Vyriad, Inc.
Phase 1/2
33
Minnesota, Ohio
2019-04-09
Active, closed
A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma
NCT03941379Choroidal Melanoma, Indeterminate Lesions of Eye
Aura Biosciences
Observational
63
Arizona, California, Massachusetts, Michigan, Minnesota, New York, Oregon, Pennsylvania
2019-03-27
Recruiting
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
NCT03876054Chronic Pain
Abbott Medical Devices
Observational
2,000
Arizona, California, Florida, Illinois, Indiana, Minnesota, Missouri, Nevada
2019-03-13
Recruiting
Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
NCT03666000Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsAzer-cel·Pirtobrutinib·Aldesleukin·Fludarabine
Imugene Limited
Phase 1
135
Florida, Georgia, Maryland, Massachusetts, Minnesota, New York, Rhode Island, Texas
2019-03-11
Recruiting
ProACT Post-Approval Study
NCT03767595Stress Urinary Incontinence
Uromedica
Not applicable
145
Colorado, Florida, Georgia, Kansas, Michigan, Minnesota
2019-02-19
Active, closed
AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment
NCT03732794Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
AtriCure, Inc.
Not applicable
150
California, District of Columbia, Illinois, Indiana, Maryland, Michigan, Minnesota, Missouri
2019-01-30
Active, closed
Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib
NCT03778229Carcinoma
DrugsSavolitinib·Osimertinib
AstraZeneca
Phase 2
367
California, District of Columbia, Maryland, Massachusetts, Minnesota, New York, Pennsylvania, Washington
2019-01-09
Active, closed
Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors
NCT03836352Ovarian Cancer, Hepatocellular Carcinoma, Non-small Cell Lung Cancer, Bladder Cancer
DrugsCyclophosphamide·Pembrolizumab
ImmunoVaccine Technologies, Inc. (IMV Inc.)
Phase 2
184
Arizona, California, Florida, Georgia, Kentucky, Louisiana, Minnesota, New Mexico
2018-12-21
Active, closed
A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma
NCT03778957Hepatocellular Carcinoma
DrugsAvastin·Durvalumab·Bevacizumab
AstraZeneca
Phase 3
724
California, District of Columbia, Florida, Hawaii, Illinois, Louisiana, Michigan, Minnesota
2018-11-30
Active, closed
A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
NCT03596645Colitis, Ulcerative
DrugsGolimumab·Infliximab
Janssen Research & Development, LLC
Phase 3
84
California, Colorado, Connecticut, Delaware, Georgia, Minnesota, New York, Tennessee
2018-10-29
Recruiting
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
NCT03567889Melanoma Stage IIIB, Melanoma Stage IIIC, Melanoma Stage IIID
DrugDaromun
Philogen S.p.A.
Phase 3
186
Arizona, California, Florida, Georgia, Illinois, Iowa, Minnesota, New Jersey
2018-09-20
Active, closed
Reducing Lung CongestIon Symptoms in Advanced Heart Failure
NCT03499236Heart Failure
V-Wave Ltd
Not applicable
605
Arizona, California, Colorado, Florida, Georgia, Illinois, Kentucky, Minnesota
2018-09-19
Active, closed
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
NCT03687593Total Knee Arthroplasty
Smith & Nephew, Inc.
Observational
126
Minnesota, Nevada, South Carolina, Tennessee
2018-08-26
Active, closed
Early Feasibility Evaluation of the AccuCinch® Ventricular Restoration System in Patients With Heart Failure and Reduced Ejection Fraction
NCT03533517Heart Failure, Cardiomyopathy, Dilated
Ancora Heart, Inc.
Not applicable
22
California, Georgia, Kentucky, Louisiana, Minnesota, Nebraska, New Jersey, New York
2018-08-23
By invitation
Advanced Materials Science in XLIF Study
NCT03649490Degenerative Disc Disease, Spondylolisthesis
NuVasive
Observational
300
Connecticut, Florida, Illinois, Kentucky, Maryland, Minnesota, Missouri, North Carolina
2018-08-19
Active, closed
Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood
NCT03793478Acute Myeloid Leukemia
DrugsQuizartinib·Cytarabine·Etoposide·Fludarabine
Daiichi Sankyo
Phase 1/2
65
California, Colorado, Delaware, District of Columbia, Georgia, Minnesota, Ohio, Pennsylvania
2018-08-15
Active, closed
Open-Label Study of AG10 in Patients with Cardiomyopathy
NCT03536767Amyloid Cardiomyopathy
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 2
55
California, Connecticut, Illinois, Massachusetts, Minnesota, New York, Oregon, South Carolina
2018-08-08
Recruiting
Early Feasibility Study - Edwards APTURE Transcatheter Shunt System
NCT03523416Heart Failure
Edwards Lifesciences
Not applicable
90
California, Colorado, Florida, Indiana, Kansas, Minnesota, New Jersey, New York
2018-07-31
Active, closed
Clinical Study of Edwards Cardioband FIT Valve Repair System
NCT03382457Tricuspid Regurgitation
Edwards Lifesciences
Not applicable
75
Illinois, Minnesota, New Jersey, New York, Oregon, Pennsylvania, Texas, Utah
2018-07-01
Active, closed
ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
NCT03499964Urethral Stricture
Urotronic Inc.
Not applicable
127
Arizona, Arkansas, Florida, Iowa, Maryland, Minnesota, Nebraska, New Jersey
2018-06-22
Recruiting
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
NCT03564340Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer
DrugsUbamatamab·Sarilumab·Cemiplimab·Tocilizumab
Regeneron Pharmaceuticals
Phase 1/2
890
Alabama, Massachusetts, Minnesota, New York, Ohio, Oklahoma, Tennessee, Texas
2018-05-21
Active, closed
Extended Access of Momelotinib in Adults With Myelofibrosis
NCT03441113Neoplasms, Post-polycythemia Vera Myelofibrosis (Post-PV MF), Primary Myelofibrosis (PMF), Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)
GlaxoSmithKline
Phase 2
237
Arizona, California, Colorado, Florida, Georgia, Maryland, Massachusetts, Minnesota
2018-05-03
Recruiting
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
NCT03424005Metastatic Breast Cancer
DrugsAtirmociclib·Ipatasertib·Giredestrant·Inavolisib
Hoffmann-La Roche
Phase 1/2
1,132
California, Colorado, Florida, Illinois, Minnesota, Nevada, New Jersey, New York
2018-03-30
Active, closed
A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and Granulocyte Colony Stimulating Factor (G-CSF) as Compared to Placebo and G-CSF for the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Subjects With Multiple Myeloma (MM)
NCT03246529Multiple Myeloma
DrugsMotixafortide·G-Csf
BioLineRx, Ltd.
Phase 3
180
California, Florida, Illinois, Maryland, Minnesota, Missouri, Ohio, Texas
2018-03-23
Active, closed
Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer
NCT03436485Prostate Cancer Metastatic
DrugsOpevesostat·Midazolam
Orion Corporation, Orion Pharma
Phase 1/2
204
Maryland, Minnesota, Nebraska, New York
2018-03-19
Active, closed
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
NCT03319485Parkinson Disease
InSightec
Not applicable
92
California, Florida, Maryland, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2018-02-09
Active, closed
PARTNER 3 Trial - Mitral Valve in Valve
NCT03193801Mitral Valve Insufficiency, Mitral Valve Disease, Mitral Valve Regurgitation, Heart Failure
Edwards Lifesciences
Not applicable
53
Georgia, Illinois, Massachusetts, Minnesota, Missouri, New York, Oregon, Texas
2018-02-01
Recruiting
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
NCT03328078Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy, Relapsed Primary Central Nervous System Lymphoma, Refractory Primary Central Nervous System Lymphoma
DrugsEmavusertib·Ibrutinib
Curis, Inc.
Phase 1/2
152
Arizona, California, Connecticut, Florida, Illinois, Massachusetts, Minnesota, Nebraska
2017-12-28
Active, closed
Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma
NCT03298451Hepatocellular Carcinoma
DrugsSorafenib·Tremelimumab·Durvalumab
AstraZeneca
Phase 3
1,324
California, District of Columbia, Florida, Kansas, Maryland, Michigan, Minnesota, New York
2017-10-11
Active, closed
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
NCT03767348Non-Small Cell Lung Cancer (NSCLC), Microsatellite Instability-High (MSI-H), Non-melanoma Skin Cancer (NMSC), Cutaneous Melanoma
DrugsVusolimogene Oderparepvec·Opdivo·Nivolumab
Replimune, Inc.
Phase 2
340
Alabama, Arizona, Arkansas, California, Florida, Iowa, Kentucky, Minnesota
2017-09-20
Active, closed
Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers
NCT03260023HPV-Related Carcinoma, HPV-Related Cervical Carcinoma, HPV-Related Anal Squamous Cell Carcinoma, HPV-Related Penile Squamous Cell Carcinoma
DrugAvelumab
Transgene
Phase 1/2
143
Florida, Minnesota
2017-09-01
Active, closed
BioVentrix Revivent TC™ System Clinical Study
NCT02931240Ventricular Dysfunction, Left
BioVentrix
Not applicable
126
Arizona, California, Florida, Georgia, Illinois, Louisiana, Michigan, Minnesota
2017-08-29
Active, closed
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
NCT02962414Tuberous Sclerosis Complex
DrugEverolimus
Novartis Pharmaceuticals
Phase 3
206
Arizona, California, Colorado, Connecticut, Illinois, Minnesota, New Jersey, Ohio
2017-08-23
Recruiting
Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)
NCT03016819Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Soft-Tissue Sarcoma
DrugsCatequentenib·Digoxin·Dacarbazine·Rosuvastatin
Advenchen Laboratories, LLC
Phase 3
325
Arizona, California, Colorado, Florida, Illinois, Michigan, Minnesota, Missouri
2017-08-15
Active, closed
Study of E7386 in Participants With Selected Advanced Neoplasms
NCT03264664Advanced Neoplasms
DrugE7386
Eisai Inc.
Phase 1
60
Arizona, California, Florida, Minnesota, Texas
2017-07-27
Active, closed
The REPLACE Registry for Cholbam® (Cholic Acid)
NCT03115086Bile Acid Synthesis Disorders
Mirum Pharmaceuticals, Inc.
Observational
55
Alabama, California, Florida, Georgia, Indiana, Louisiana, Minnesota, Missouri
2017-07-10
Active, closed
A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
NCT03162536Lymphoma, B-Cell, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia
DrugNemtabrutinib
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Phase 1/2
190
Arizona, California, Colorado, Michigan, Minnesota, North Carolina, Ohio, Tennessee
2017-06-26
Active, closed
A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL
NCT02970318Chronic Lymphocytic Leukemia
DrugsIdelalisib·Acalabrutinib·Bendamustine·Rituximab
Acerta Pharma BV
Phase 3
310
Arizona, California, Georgia, Illinois, Iowa, Kentucky, Minnesota, Nebraska
2017-02-02
Active, closed
Characterizing Outcomes and Real-World Experience of Cardiac Physiologic Pacing (The CORE-CPP Study)
NCT06606288Heart Failure
Medtronic Cardiac Rhythm and Heart Failure
Observational
6,000
Minnesota
2017-01-01
Active, closed
The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
NCT02979587Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
Medtronic Heart Valves
Not applicable
86
California, Connecticut, Minnesota, Ohio, Pennsylvania, Texas, Utah, Washington
2017-01
Active, closed
Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants
NCT02938520HIV Infections
DrugsCabotegravir (CAB)·Rilpivirine (RPV)·Rilpivirine·Cabotegravir
ViiV Healthcare
Phase 3
631
Alabama, California, Colorado, District of Columbia, Florida, Georgia, Indiana, Minnesota
2016-10-27
Recruiting
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
NCT02744677Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration
Edwards Lifesciences
Not applicable
108
Alabama, Arkansas, California, Colorado, Georgia, Kentucky, Massachusetts, Minnesota
2016-07-05
Active, closed
Study of Iomab-B vs. Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia
NCT02665065Acute Myeloid Leukemia, Leukemia, Acute Myeloid, Myeloid Leukemia, Acute, Leukemia, Myeloid, Acute
Actinium Pharmaceuticals
Phase 3
153
Arizona, Connecticut, District of Columbia, Florida, Illinois, Iowa, Kansas, Minnesota
2016-06
Active, closed
Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer
NCT02609776Non-Small-Cell Lung Cancer
DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin
Janssen Research & Development, LLC
Phase 1
751
California, Florida, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri
2016-05-24
Active, closed
A Study of the Safety and Effectiveness of the Mentor Larger Size MemoryGel Ultra High Profile Breast Implants in Subjects Who Are Undergoing Primary Breast Reconstruction or Revision Reconstruction
NCT02724371Breast Reconstruction, Revision Breast Reconstruction
Mentor Worldwide, LLC
Not applicable
400
Alabama, Arizona, California, Georgia, Indiana, Iowa, Kansas, Minnesota
2016-04-01
Active, closed
Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System
NCT02514525Barrett Esophagus
Pentax Medical
Not applicable
150
California, Florida, Illinois, Maryland, Minnesota, New York, North Carolina, Ohio
2016-03
Recruiting
Post-Exablate Pregnancy Outcomes Registry Study: Exablate Treatment of Symptomatic Uterine Fibroids
NCT05386615Uterine Fibroid
InSightec
Observational
200
California, Minnesota
2016-02-16
Active, closed
Long-term Follow-up of Participants With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product
NCT02698579Cerebral Adrenoleukodystrophy (CALD), Adrenoleukodystrophy (ALD), X-Linked Adrenoleukodystrophy (X-ALD)
Genetix Biotherapeutics Inc.
Observational
64
California, Massachusetts, Minnesota
2016-01-22
Recruiting
CAR-T Long Term Follow Up (LTFU) Study
NCT02445222Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program
Novartis Pharmaceuticals
Phase 3
1,105
Arizona, California, Georgia, Illinois, Kansas, Massachusetts, Michigan, Minnesota
2015-11-02
Active, closed
Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)
NCT02477696Chronic Lymphocytic Leukemia
DrugsIbrutinib·Acalabrutinib
Acerta Pharma BV
Phase 3
533
Arizona, California, Florida, Georgia, Illinois, Kansas, Minnesota, Montana
2015-07-28
Active, closed
Phase III Open Label First Line Therapy Study of MEDI 4736 (Durvalumab) With or Without Tremelimumab Versus SOC in Non Small-Cell Lung Cancer (NSCLC)
NCT02453282Non-Small-Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
1,118
Arizona, California, Connecticut, Florida, Georgia, Hawaii, Maryland, Minnesota
2015-07-21
Recruiting
Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
NCT02235857Focal Segmental Glomerulosclerosis
Kaneka Medical America LLC
Not applicable
35
California, Delaware, Florida, Michigan, Minnesota, New York, North Carolina, Ohio
2015-05-03
Active, closed
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
NCT02365597Urothelial Cancer
DrugsErdafitinib·Midazolam·Metformin
Janssen Research & Development, LLC
Phase 2
239
Arizona, California, Colorado, District of Columbia, Illinois, Iowa, Kentucky, Minnesota
2015-04-22
Active, closed
Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System
NCT02322840Mitral Valve Insufficiency
Medtronic Cardiovascular
Not applicable
128
Arizona, California, Georgia, Illinois, Michigan, Minnesota, Missouri, New York
2015-04
By invitation
Registry of Patients With Hypophosphatasia
NCT02306720Hypophosphatasia (HPP)
Alexion Pharmaceuticals, Inc.
Observational
1,571
Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Minnesota, Missouri
2015-01-20
Active, closed
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
NCT02246621Breast Cancer
DrugsAnastrozole·Abemaciclib·Letrozole
Eli Lilly and Company
Phase 3
493
Arizona, Arkansas, California, Florida, Georgia, Minnesota, Nebraska, Nevada
2014-11-06
Active, closed
An Open-label, Phase 2 Study of ACP-196 in Subjects With Waldenström Macroglobulinemia
NCT02180724Waldenström Macroglobulinemia (WM)
DrugAcalabrutinib
Acerta Pharma BV
Phase 2
107
California, Colorado, District of Columbia, Minnesota, New York, Tennessee, Texas, Washington
2014-09-11
Active, closed
A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread
NCT02057133Breast Neoplasms
DrugsLoperamide·Samotolisib·Tamoxifen·Exemestane
Eli Lilly and Company
Phase 1
198
Arkansas, California, Massachusetts, Minnesota, New York, North Carolina, Oregon, Pennsylvania
2014-03-10
Recruiting
Lysosomal Acid Lipase (LAL) Deficiency Registry
NCT01633489Lysosomal Acid Lipase Deficiency, Cholesterol Ester Storage Disease, Wolman Disease, Acid Cholesteryl Ester Hydrolase Deficiency, Type 2
Alexion Pharmaceuticals, Inc.
Observational
300
Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota
2013-05-30
Active, closed
Open-Label Single Ascending Dose of Adeno-associated Virus Serotype 8 Factor IX Gene Therapy in Adults With Hemophilia B
NCT01687608Hemophilia B
Baxalta now part of Shire
Phase 1/2
30
California, Colorado, Georgia, Illinois, Massachusetts, Minnesota, New York, Oregon
2013-02-11
Active, closed
DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support Study
NCT01321073Pulmonary Arterial Hypertension
Medtronic Cardiac Rhythm and Heart Failure
Not applicable
64
Alabama, California, Florida, Illinois, Massachusetts, Minnesota, Texas, Wisconsin
2011-06
By invitation
Comprehensive Reverse Shoulder Data Collection
NCT03404778Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects
Zimmer Biomet
Observational
175
Maryland, Michigan, Minnesota, Ohio
2010-03-07
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/minnesota?page=2

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 924 of those studies with a site in Minnesota.

How many clinical trials are recruiting in Minnesota?

493 of the 924 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 21 have not yet opened recruitment, 383 are active but closed to new participants, and 27 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.