Clinical trial register · France

Clinical Trials in Nantes, 2026

Every study on the ClinicalTrials.gov registry that lists a site in France and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 9697 matching records held by the registry are in this view. Synced 26 Oct 2026, 03:20 UTC

9697

Studies in scope

all four open statuses

6025

Recruiting now

open to new participants

1033

Lead sponsors

across recruiting studies

Top sites

Paris 2821 Lyon 1392 Bordeaux 1389 Marseille 1285 Lille 1282

Trials with a site in Nantes

Status

Study

Lead sponsor

Phase

Enrol

Sites in France

Start

Not yet open

Cardiac Improvement by Eplerenone Among Patients Under Cyclosporine or Tacrolimus for Kidney Transplantation.

NCT07828223Kidney Transplantation

DrugEplerenone

Central Hospital, Nancy, France

Phase 3

132

Nantes, Strasbourg, Vandœuvre-lès-Nancy

2027-02

Not yet open

"Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study."

NCT07869173Chronic Pain

DrugLidocain

Nantes University Hospital

Phase 3

266

Angers, Brest, La Roche-sur-Yon, Nantes, Rennes, Toulouse

2027-01-15

Not yet open

Real World Positioning of Tyrosine Kinase Inhibitors (TKIs) Within Systemic Treatment Strategies for Advanced Neuroendocrine Tumors (NETs)

NCT07890012Well-Differentiated Neuroendocrine Tumors (NETs)

Hospices Civils de Lyon

Observational

100

Angers, Caen, Clichy, Dijon, La Tronche, Lille, Lyon, Nantes

2027-01-01

Not yet open

Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study

NCT06435299Pruritus

DrugCannabis oil

University Hospital, Brest

Phase 2

218

Angers, La Roche-sur-Yon, La Rochelle, Nantes, Poitiers, Tours

2027-01-01

Not yet open

Efanesoctocog Prophylaxis Or The Optimization Of Treatment: Real-World Experience Of Taylorizing Clotting Therapy In Hemophilia A

NCT07830693Hemophilia A Patient

Nantes University Hospital

Observational

553

Angers, Bordeaux, Brest, Caen, Chambray-lès-Tours, Le Mans, Nantes, Rennes

2027-01-01

Not yet open

"Anticipant"-TIPS After a First Portal-hypertension-related Complication in Cirrhosis

NCT07889726Cirrhosis

University Hospital, Toulouse

Not applicable

266

Besançon, Créteil, Lyon, Marseille, Nantes, Paris, Rennes, Toulouse

2027-01-01

Not yet open

Dexmedetomidine for Invasive Ventilation In the NEOnate

NCT07493785Invasive Ventilation, Infant Pain, Infant Discomfort, Infant Neurodevelopment

DrugDexmedetomidine

Centre Hospitalier Intercommunal Creteil

Phase 2/3

246

Brest, Créteil, Grenoble, Lille, Limoges, Nantes, Nice, Paris

2027-01-01

Not yet open

Efficacy of Botulinum Toxin Versus Placebo on Pain and Health Related Quality of Life of Patients With Piriformis Muscle Syndrome

NCT07624045Piriformis Muscle Syndrome

DrugBotulinum toxin A

Centre Hospitalier Universitaire de Nīmes

Phase 2

108

Nîmes, Besançon, Bordeaux, Nantes, Paris, Strasbourg, Toulouse

2027-01

Not yet open

Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis

NCT07441408Pulmonary Fibrosis

DrugAdmilparant

Bristol-Myers Squibb

Phase 3

2,380

Grenoble, Angers, Nantes, Marseille, Bobigny, Brest, Dijon, Nice

2026-12-16

Not yet open

tDCS and Symptom Provocation in Treatment-Resistant OCD

NCT07429500Obsessive - Compulsive Disorder

Centre Hospitalier Henri Laborit

Not applicable

178

Angoulême, Limoges, Nantes, Poitiers, Rennes, Thouars

2026-12-01

Not yet open

Epcoritamab Plus Lenalidomide in Relapsed/Refractory Large B-cell Lymphoma After Second-Line CAR T-cell Therapy

NCT07814001Refractory Diffuse Large B-Cell Lymphoma (DLBCL), Refractory Large B-cell Lymphoma (LBCL), Refractory T-cell/Histiocyte-rich Large B-cell Lymphoma, Refractory Transformed Follicular Lymphoma

DrugsEpcoritamab·Lenalidomide

The Lymphoma Academic Research Organisation

Phase 2

Créteil, Dijon, Lille, Limoges, Lyon, Marseille, Montpellier, Nantes

2026-12

Not yet open

Early Intervention in Remote Autism (IPAAD)

NCT04660669Early Intervention in Remote Autism

University Hospital, Brest

Not applicable

Nantes, Cergy-Pontoise, Le Havre, Limoges

2026-12

Not yet open

A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma

NCT07728188Relapsed or Refractory Multiple Myeloma

DrugsEtentamig·Teclistamab·Carfilzomib·Pomalidomide

AbbVie

Phase 3

520

Nice, Tours, Vandœuvre-lès-Nancy, Nantes, Avignon

2026-11-30

Not yet open

Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care

NCT07542990Delirium in the Intensive Care Unit

DrugsMidazolam·Dexmedetomidine

University Hospital, Tours

Phase 3

266

Angers, Caen, Lille, Marseille, Nantes, Strasbourg, Tours

2026-11-15

Not yet open

Evaluating the Therapeutic Potential of Focal Electrically Administered Seizure Therapy (FEAST) in the Treatment of Depression: A Multicenter Randomized Clinical Trial

NCT07857122Major Depressive Episode (MDE), Unipolar Disorder, Bipolar 1 Disorder

Centre Hospitalier St Anne

Not applicable

108

Bron, Nantes, Paris, Sotteville-lès-Rouen

2026-11-02

Not yet open

Follow-up of the Cohort of Newborns Screened at Birth Using TREC Analysis

NCT07704281Severe Combined Immunodeficiencies (SCID)

Nantes University Hospital

Observational

450

Nantes

2026-11-01

Recruiting

Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of Trapeziometacarpal Osteoarthritis

NCT07435571Trapeziometacarpal Osteoarthritis

TBF Genie Tissulaire

Phase 2

Lyon, Nantes, Saint-Jean-de-Védas

2026-11

Recruiting

Bedside Spirometry for Acute Lung Injury

NCT07750717Respiratory Insufficiency

Centre Hospitalier Departemental Vendee

Not applicable

La Roche-sur-Yon, Nantes

2026-10-16

Not yet open

A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A

NCT07830732Haemophilia A

Novo Nordisk A/S

Phase 3

Bron, Le Kremlin-Bicêtre, Lille, Nantes

2026-10-09

Recruiting

Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot Study

NCT07391332Gambling Disorder

Nantes University Hospital

Phase 2

Nantes

2026-10-08

Recruiting

"IL-1β Blockade to Prevent Immunothrombosis in Recipients of a Pancreatic Organ"

NCT07503834Pancreatic Transplant

Nantes University Hospital

Phase 1/2

Nantes

2026-10-07

Not yet open

Isolation of Pulmonary Veins Using the Box Technique in Patients Undergoing Sternotomy

NCT07312149Atrial Fibrillation (AF), Cardiac Surgery

Nantes University Hospital

Observational

200

Nantes

2026-10-05

Recruiting

Multimodal Approach Feasability Study for Untreated and Unruptured Intracranial Aneurysms

NCT07864389Aneurysm Cerebral (Unruptured)

Resolve Stroke

Not applicable

Nantes

2026-10-05

Not yet open

Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease

NCT05584228Crohn Disease

DrugsAzathioprine·Infliximab

Nantes University Hospital

Not applicable

150

Nantes

2026-10-01

Not yet open

Weight Trajectories and Predictive Factors After Semaglutide in Patients With Grade 3 and Complicated Obesity

NCT07423481Obesity & Overweight

Nantes University Hospital

Observational

3,000

Nantes

2026-10-01

Not yet open

Effectiveness of a Communication Training Program in Improving the Handling of Calls for Suspected Cardiac Arrest at SAMU-Centre 15.

NCT07776990Cardiac Arrest (CA)

University Hospital, Grenoble

Not applicable

987

Annecy, Bordeaux, Chambéry, La Roche-sur-Yon, Lyon, Nancy, Nantes, Rennes

2026-10-01

Recruiting

ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Cardiac Death in Moderated LVEF in ischEmic cardiomyopathY

NCT07545512Myocardial Infarction (MI), Sudden Cardiac Death Due to Cardiac Arrhythmia

University Hospital, Clermont-Ferrand

Not applicable

400

Amiens, Brest, Caen, Clermont-Ferrand, Lyon, Nancy, Nantes, Paris

2026-10-01

Not yet open

Cost-utility Analysis of Outpatient Manual Vacuum Aspiration Versus Operating Room Electric Aspiration for the Management of First-trimester Miscarriage

NCT07732231Miscarriage, Pregnancy Loss, First Trimester Pregnancy

Nantes University Hospital

Not applicable

860

Nantes

2026-10-01

Not yet open

Physiopathology of Behavioral Addictions and Biomarkers

NCT07830680Food Addiction, Sexual Addiction

DrugBlood sampling

Nantes University Hospital

Observational

Nantes

2026-10-01

Not yet open

Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)

NCT07871227Colorectal Neoplasms

University Hospital, Bordeaux

Observational

1,200

Angers, Dijon, Limoges, Lyon, Nantes, Nîmes, Paris, Pessac

2026-10

Not yet open

Immunogenicity and Safety of Two Respiratory Syncytial Virus Vaccine Strategies in Lung and Allogeneic Haematopoietic Stem Cell Transplant Recipients.

NCT07863401Immunocompromised Patients

Hospices Civils de Lyon

Phase 2

400

Bron, Créteil, Le Plessis-Robinson, Lyon, Marseille, Nantes, Paris, Pessac

2026-10

Recruiting

Reassessment of the Risk of Hemolytic Syndrome in Patients With Chronic Lymphocytic Leukemia Treated With a Regimen Containing Venetoclax

NCT07691047Chronic Lymphoid Leukemia

Private Hospital of Confluent, France

Not applicable

130

Amiens, Nantes

2026-09-30

Recruiting

A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).

NCT07735637Newly Diagnosed Multiple Myeloma (NDMM)

DrugsASCT·AZD0120·Melphalan·Lenalidomide

AstraZeneca

Phase 3

750

Lille, Nantes, Paris, Toulouse

2026-09-24

Not yet open

Study Evaluating the Effect of Transcranial Direct Current Stimulation (tDCS) Targeting the Right Inferior Frontal Gyrus on Inhibitory Control in Patients With PSP

NCT07818733PSP - Progressive Supranuclear Palsy

Nantes University Hospital

Not applicable

Nantes

2026-09-15

Not yet open

Assessment of Information Provided on Infectious Risk in Solid Organ Transplantation

NCT07788417Transplantation Infection, Pulmonary Transplantation

Fondation Hôpital Saint-Joseph

Observational

1,000

Paris, Bordeaux, Lyon, Marseille, Nantes, Strasbourg, Suresnes

2026-09-15

Recruiting

Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies

NCT07648264Secondary Immune Deficiency

DrugHizentra

CSL Behring

Phase 3

Rennes, Nantes, Angers, La Roche-sur-Yon, Rouen

2026-09-15

Not yet open

Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP)

NCT07640009Death, Brain

Centre Hospitalier Régional d'Orléans

Not applicable

Angers, Nantes, Orléans, Tours

2026-09-15

Not yet open

TicAgreLor Versus Placebo to Prevent Cerebral ISCHemia in anEuRysmal Low Grade SAH A Double Blinded Randomised Controlled Study

NCT07821008Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia, Endovascular Procedure

University Hospital, Toulouse

Phase 3

274

Bordeaux, Montpellier, Nantes, Paris, Strasbourg, Toulouse, Tours

2026-09-14

Recruiting

Exploratory Study Evaluating the Relevance of [68Ga]Ga-FAPI-46 for Staging and Identifying Progressing Patients With Transthyretin Cardiac Amyloidosis

NCT07549841Transthyretin Cardiac Amyloidosis

Drug[68Ga]Ga-FAPI-46

Nantes University Hospital

Phase 2

Nantes

2026-09-09

Recruiting

A Study of Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) or Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With NDMM For Whom Stem Cell Transplant is Not Planned

NCT07665450Multiple Myeloma

DrugsRamantamig·Bortezomib·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,000

Nantes, Pierre-Bénite

2026-09-09

Recruiting

Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)

NCT07680790Non-Small Cell Lung Cancer

DrugsIza-bren·Osimertinib·Pemetrexed·Cisplatin

Bristol-Myers Squibb

Phase 3

850

Marseille, Dijon, Nantes, La Tronche, Lyon, Paris, Bron, Villejuif

2026-09-08

Not yet open

Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches

NCT07660510Neuropathic Pain, Nociplastic Pain

Nantes University Hospital

Not applicable

Nantes

2026-09-01

Not yet open

Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children

NCT07587450Acute Uncomplicated Appendicitis

DrugAmoxi Clavulanate

University Hospital, Toulouse

Phase 3

724

Bordeaux, Grenoble, Lille, Limoges, Marseille, Montpellier, Nantes, Paris

2026-09-01

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 Skipping

NCT07587242Muscular Dystrophies, Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy), Muscular Disorders, Atrophic, Muscular Disease

DrugAOC 1044

Avidity Biosciences, Inc.

Phase 3

Nantes, Paris

2026-09-01

Not yet open

Immune Monitoring Following B-cell Depletion in ANCA-associated Vasculitis

NCT07636655Vasculitis Associated With Anti-neutrophil Cytoplasmic Antibodies

Nantes University Hospital

Observational

120

Nantes

2026-09-01

Not yet open

Evaluation of the Efficacy of Ischemic Preconditioning to Protect Against Acute Kidney Injury After Open Surgery for Juxtarenal Abdominal Aortic Aneurysm

NCT07441564Aneurysm Aortic

University Hospital, Rouen

Not applicable

206

Dijon, Lille, Nancy, Nantes, Paris, Rouen, Toulouse

2026-09-01

Not yet open

Two Modalities of Ventilation on the Occurrence of Respiratory Complications During Inhalational Anaesthetic Induction in Children

NCT07767851Anaesthetic Induction, Respiratory Complications of Care, Pediatrics, Ventilation

Hospices Civils de Lyon

Not applicable

2,032

Lyon, Marseille, Montpellier, Nantes, Paris, Reims, Strasbourg, Toulouse

2026-09-01

Not yet open

AspergillusOne-Health: Deciphering Azole Resistance in Aspergillus Fungi Using a One Health Approach

NCT06532227Aspergillus Fumigatus Infection

Nantes University Hospital

Observational

1,000

Nantes

2026-09-01

Not yet open

Multicentre Study Evaluating the Efficacy of a 7-day Course of Doxycycline for the Treatment of Asymptomatic Anal Lymphogranuloma Venereum.

NCT07767422Lymphogranuloma Venereum, no Anorectal Symptoms, Doxycycline

University Hospital, Bordeaux

Phase 2

120

Bordeaux, Dijon, Lyon, Marseille, Montreuil, Nantes, Paris, Toulouse

2026-09

Recruiting

Synovial Tissue as a Biomarker in the Management of Pigmented Villonodular Synovitis

NCT07503821Synovitis Villonodular

Nantes University Hospital

Not applicable

Lyon, Nantes, Paris

2026-09

Not yet open

Acetylsalicylic Acid Versus Placebo as an add-on Treatment to Local Non-steroidal Anti-inflammatory Drug for the Management of Thrombotic Episodes in Superficial Venous Malformations in Children Aged 6 to 17 Years.

NCT07663825Venous Malformation, Low Flow, Venous Malformations

University Hospital, Tours

Phase 2

Angers, Brest, Marseille, Nantes, Paris, Rennes

2026-09

Recruiting

Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Atrasentan in Pediatric Patients With Primary IgAN

NCT07498335Berger Disease, Bergers Disease, IgA Nephropathy, Immunoglobulin A Nephropathy

DrugAtrasentan

Novartis Pharmaceuticals

Phase 3

Bron, Nantes, Toulouse

2026-08-06

Recruiting

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study

NCT07746895C3 Glomerulopathy (C3G), Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)

DrugPegcetacoplan

Swedish Orphan Biovitrum

Phase 4

150

Bordeaux, Bron, Créteil, Lille, Marseille, Montpellier, Nantes, Paris

2026-08-05

Not yet open

An Ambispective Natural History Study in Myotonic Dystrophy Patients Linking Retrospective Data Captured From the DM-Scope Registry With a Prospective 24-month Follow-up Period

NCT07732439Myotonic Dystrophy 1, Myotonic Dystrophy 2

Lupin Ltd.

Observational

100

Angers, Lille, Marseille, Nantes, Paris, Toulouse

2026-08-03

Recruiting

A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)

NCT07742735Short Bowel Syndrome (SBS), SBS Associated With Intestinal Failure (SBS-IF)

DrugApraglutide

VectivBio AG

Phase 3

124

Clichy, Lyon, Nantes, Pessac, Vandœuvre-lès-Nancy

2026-08

Recruiting

Comparison of the Efficacy of Transcranial Direct Current Stimulation at Home Versus in Hospital Settings in Patients With Depressive Episodes

NCT07490379Depression

Nantes University Hospital

Not applicable

Anglet, La Roche-sur-Yon, Nantes, Nîmes, Sotteville-lès-Rouen, Thuir

2026-07-31

Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

NCT07497087Systemic Sclerosis

Boehringer Ingelheim

Phase 3

448

Bordeaux, Brest, Caen, Epagny Metz-Tessy, Marseille, Nantes, Paris, Rennes

2026-07-27

Recruiting

Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment

NCT07444567Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES)

DrugsFasenra·Benralizumab

AstraZeneca

Phase 3

230

Bron, Marseille, Montpellier, Nantes, Paris, Pessac, Suresnes

2026-07-24

Recruiting

Preoperative Use of Romiplostim in Thrombocytopenic Patients Undergoing Cardiac Surgery.

NCT07278661Chirurgical Intervention, Thrombocytopaenia

DrugNplate

Nantes University Hospital

Phase 2

136

Angers, Bordeaux, Brest, Dijon, Nantes, Paris, Rennes, Strasbourg

2026-07-16

Recruiting

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial

NCT06381661Sepsis

DrugsSivelestat·Fludrocortisone·Low molecular weight heparin·Anakinra

Assistance Publique - Hôpitaux de Paris

Phase 2

2,000

Dijon, Étampes, Garches, Haguenau, La Roche-sur-Yon, Le Mans, Nancy, Nantes

2026-07-09

Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

NCT07630974Malignant Neoplasm

DrugIfinatamab Deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

134

Bordeaux, Nantes, Lyon

2026-07-06

Recruiting

Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease

NCT07274254Vaso-Occlusive Pain Episode in Sickle Cell Disease

DrugLidocain

Nantes University Hospital

Phase 3

104

Bordeaux, Lille, Marseille, Nantes, Orléans, Paris, Poitiers, Rouen

2026-07-03

Not yet open

Strategies for Weaning From External Ventricular Drainage

NCT07630051Subarachnoid Hemorrhage, Hydrocephalus, Intracranial Hypertension, External Ventricular Drainage

University Hospital, Angers

Not applicable

170

Angers, Brest, Nantes, Poitiers, Rennes

2026-07-01

Recruiting

A Study Evaluating the Prophylactic Use of Tocilizumab to Prevent Cytokine Release Syndrome With Ramantamig Administration in Participants With Relapsed/Refractory Multiple Myeloma

NCT07589634Multiple Myeloma

DrugsRamantamig·Tocilizumab

Janssen Research & Development, LLC

Phase 2

230

Argenteuil, Bayonne, Le Mans, Nantes

2026-06-30

Recruiting

Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms

NCT07638553Alcohol Use Disorder, Depressive Sympotoms, Psilocybin

DrugPsilocybin

Centre Hospitalier Universitaire de Nīmes

Phase 3

172

Bayonne, Besançon, Bordeaux, Brest, Bron, Nantes, Nîmes, Saint-Priest

2026-06-30

Recruiting

Relevance of the Urine Bacterial Culture Performed Before TransUrethral Resection of the Bladder for Post-operative Febrile Urinary Tract Infections Prevention: a Non-inferiority Randomized Controlled Trial

NCT07463963Bladder Cancer, Transurethral Resection of the Bladder, Urinary Tract Infection Bacterial

Poitiers University Hospital

Not applicable

2,600

Angers, Grenoble, Le Coudray, Lille, Lyon, Marseille, Mont-de-Marsan, Nantes

2026-06-29

Recruiting

Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT

NCT07764978Newly Diagnosed Multiple Myeloma

DrugsAZD0120·Isatuximab·Bortezomib·Daratumumab

AstraZeneca

Phase 3

750

Lille, Nantes, Paris, Poitiers, Toulouse

2026-06-26

Not yet open

A Pilot Superiority Study Comparing the Efficacy of a Combination of a Glenohumeral Intra-articular Injection With a Suprascapular Nerve Block Versus a Glenohumeral Intra-articular Corticosteroid Injection in Retractile Capsulitis

NCT07680504Retractile Capsulitis

Nantes University Hospital

Phase 2

Nantes

2026-06-25

Recruiting

Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma

NCT07555938Multiple Myeloma

DrugsCevostamab·Elotuzumab·Carfilzomib·Pomalidomide

Hoffmann-La Roche

Phase 3

380

Nantes, Lille, Pierre-Benite (Lyon), Poitiers, Toulouse

2026-06-23

Recruiting

A Study of ARC-02 in B-cell NHL

NCT07691606B-cell Non Hodgkin Lymphoma

DrugRituximab

Taiho Oncology, Inc.

Phase 1

140

Créteil, Lille, Lyon, Nantes, Villejuif

2026-06-22

Recruiting

Efficacy of 12-week Daytime Restricted Eating on Hepatic Steatosis of Obesity

NCT07378072MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)

Nantes University Hospital

Not applicable

Angers, Bordeaux, Dijon, Lyon, Marseille, Montpellier, Nantes, Paris

2026-06-17

Recruiting

IPSTRAUC : Impact on Care Pathways of a New Management of Cervical Trauma in Conscious Patients Stable in Pre-hospital Care

NCT06983873Prehospital Emergency, Neck Injury, Neck Trauma, Emergency Medical Services

Rennes University Hospital

Not applicable

840

Amiens, Besançon, Corbeil-Essonnes, Grenoble, La Rochelle, Marseille, Nancy, Nantes

2026-06-17

Recruiting

Genotype/Phenotype Correlation of MORC2 Mutations

NCT07038239Charcot Marie Tooth Disease, DIFGAN, Developmental Delay (Disorder), Impaired Growth

Hospices Civils de Lyon

Observational

Besançon, Brest, Grenoble, Le Chesnay, Le Kremlin-Bicêtre, Lyon, Marseille, Nantes

2026-06-16

Recruiting

Open Label Extension to Assess Long Term Safety and Efficacy of KL1333 in Patients With Primary Mitochondrial Disease

NCT07514338Mitochondrial Diseases

DrugNapazimone

Pharming Technologies B.V.

Phase 2

140

Angers, Bordeaux, Lille, Nantes, Nice, Strasbourg

2026-06-12

Recruiting

Assessment of the Feasibility and Organisational Impact of a Care Pathway Incorporating the MultiSense® Medical Device for Post-operative Home Monitoring of Elderly Patients.

NCT07514286Average Length of Stay, Surgery

Rhythm Diagnostic Systems

Not applicable

Angers, Bordeaux, Mont-de-Marsan, Nantes

2026-06-03

Recruiting

A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy

NCT07498426Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)

Novartis Pharmaceuticals

Phase 3

300

Caen, Créteil, Lille, Marseille, Nantes, Paris, Rennes, Toulouse

2026-06-03

Not yet open

The MAI-FOIE Cohort

NCT07594990Autoimmune Liver Diseases, Immunological Mechanisms

Nantes University Hospital

Observational

800

Angers, Brest, Clichy, La Roche-sur-Yon, Lille, Lyon, Nantes, Paris

2026-06-01

Not yet open

Research for Resistance Factors in the Treatment of Lymphoid Hemopathy

NCT07385612MATURE B-CELL LYMPHOIDS

Nantes University Hospital

Observational

La Roche-sur-Yon, Nantes, Poitiers, Saint-Nazaire

2026-06-01

Not yet open

Study of NK Cells in the Monitoring of Patients With Acute Leukemia or Myelodysplasia

NCT07249476Leukaemia (Acute Myeloid), Leukaemia (Acute Lymphoblastic), Myelodysplastic Syndrome

Nantes University Hospital

Observational

Nantes

2026-06-01

Not yet open

A Prospective Randomized Study Comparing the Safety of Percutaneous and Open Brachial Access in the Endovascular Treatment of Peripheral Arterial Lesion

NCT07573644Endovascular Treatments, Endovascular Surgery, Peripheral Arterial

University Hospital, Brest

Not applicable

246

Angers, Bordeaux, Brest, Cholet, La Roche-sur-Yon, Lorient, Nantes, Paris

2026-06-01

Not yet open

Impact of Artificial Intelligence Algorithm-driven Versus Standard Lifestyle Intervention in Non-Alcoholic Fatty Liver Disease - A Multicenter, Randomized, Open-label, Controlled Trial

NCT07497750Non Alcoholic Fatty Liver Disease

University Hospital, Toulouse

Not applicable

216

Angers, Clichy, Dijon, Lyon, Nantes, Paris, Pessac, Toulouse

2026-06-01

Recruiting

GOAT (Gait Observation of Achilles Tendon)

NCT07467382Spastic Paresis, Stroke, Spinal Cord Injury

Nantes University Hospital

Observational

Nantes

2026-06-01

Not yet open

Frequency and Intensity of Inflammatory Relapses in Patients With Non-infectious Posterior Uveitis Treated With a Fluocinolone Acetonide Implant

NCT07423442Noninfectious Posterior Uveitis, Uveitis, Posterior, Uveitic Macular Edema

DrugFluocinolone acetonide implant

Nantes University Hospital

Observational

100

Nantes

2026-06

Not yet open

Implementation Trial In patieNts With rEnal failuRe and diAbetes for Major Adverse reNal and Cardiovascular Events

NCT07634718Diabetes, Renal Failure , Chronic

Nantes University Hospital

Not applicable

125,000

Nantes

2026-06

Not yet open

Denys-Drash Syndrome and Risk of Post-transplant Lymphoproliferative Disorder

NCT07605884Denys-Drash Syndrome

Assistance Publique - Hôpitaux de Paris

Observational

108

Bron, Lille, Montpellier, Nancy, Nantes, Paris

2026-06

Recruiting

A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT07518186Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

700

Amiens, Lyon, Montpellier, Nantes, Poitiers, Talence, Toulouse, Tours

2026-05-31

Not yet open

Prospective Evaluation of Adler Laboratory's Massive Prosthetic Implants in Oncological and Non-oncological Situations

NCT07369778Reconstruction of Massive Bone Loss (Oncologic and Non-oncologic)

Nantes University Hospital

Observational

375

Nantes

2026-05-30

Recruiting

Synovial Tissue as a Biomarker in the Early Management of Osteoarthritis

NCT07473414Osteoarthritis

Nantes University Hospital

Not applicable

Nantes

2026-05-26

Recruiting

BIO|STREAM.CSP Study

NCT07393009Cardiac Pacing, Cardiac Pacemaker, Implantable Cardioverter Defibrillator, Cardiac Resynchronization Therapy Devices

Biotronik SE & Co. KG

Observational

1,000

Clermont-Ferrand, Marseille, Metz, Nantes, Pessac, Saint-Laurent-du-Var

2026-05-25

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis

NCT07577856Colitis, Ulcerative

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

644

Amiens, Besançon, Clichy, Le Kremlin-Bicêtre, Lille, Montpellier, Nantes, Nice

2026-05-23

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease

NCT07577843Crohn Disease

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

460

Besançon, Clichy, Le Kremlin-Bicêtre, Lille, Montpellier, Nantes, Nice, Pessac

2026-05-22

Recruiting

Creation of a Biocollection of Patients With Acute Myeloid Leukemia (AML) or Lymphoid Leukemia (ALL) or High-risk Myelodysplastic Syndrome (MDS) Monitored at the Nantes University Hospital

NCT06681363Acute Myeloid Leucemia, High-risk Myelodysplastic Syndrome (MDS), Acute Lymphoid Leukemia

Nantes University Hospital

Observational

1,000

Nantes

2026-05-21

Recruiting

Clinical Relevance of Ultrasound-based Intramuscular Fat Infiltration Assessment in Hospitalized Older Adults (FATUS-OLD)

NCT07411547Physical Performance Decline in Older Adults, Sarcopenia, Muscle Fat Infiltration

Nantes University Hospital

Observational

115

Nantes

2026-05-21

Recruiting

Pharmaco Mechanical Thrombolysis Associated With Anticoagulation Compared With Anticoagulation in the Acute Phase of Very Symptomatic Proximal Venous Thrombosis of the Lower Limbs.

NCT06472518Iliofemoral Venous Thrombosis

Nantes University Hospital

Phase 4

228

Nantes

2026-05-20

Recruiting

Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1

NCT07486934Myotonic Dystrophy Type 1 (DM1), DM1, Myotonic Dystrophy, Steinert Disease

DrugZeleciment basivarsen

Dyne Therapeutics

Phase 3

150

Garches, Marseille, Nantes, Paris, Toulouse

2026-05-14

Recruiting

A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis

NCT07387549Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 3

350

Lille, Lyon, Montpellier, Nantes, Paris, Toulouse, Villejuif

2026-05-14

Recruiting

Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica

NCT07286214Polymyalgia Rheumatica

DrugSarilumab

Sanofi

Phase 3

300

Nantes, Toulouse

2026-05-12

Active, closed

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

NCT07517263Cardiovascular Disease and Lipoprotein(a)

DrugPelacarsen

Novartis Pharmaceuticals

Phase 3

5,700

Bron, Chambray-lès-Tours, Compiègne, Grenoble, Le Coudray, Nantes, Paris, Toulouse

2026-05-11

Recruiting

Dental Management of Patients With HIV in Pays de la Loire

NCT07552038HIV Infection, Acquired Immune Deficiency Syndrome, Oral Health Care

Nantes University Hospital

Observational

5,603

Nantes

2026-05-02

Not yet open

A Randomized Non-Inferiority Study of Mepi™ Press 2 vs UrgoK2® for Compression Therapy in Venous Leg Ulcers

NCT07600489Venous Leg Ulcer (VLU), Compression Bandages

Molnlycke Health Care AB

Not applicable

386

Castelnau-le-Lez, Grenoble, Lyon, Nantes, Poitiers, Toulouse

2026-05

Recruiting

Outpatient Induction of Labour Using a Double Balloon Transcervical Catheter in Low-risk Pregnant Women: a Two-centre Open Prospective Randomised Controlled Trial - OutCRIB

NCT07265518Pregnant Women

Nantes University Hospital

Not applicable

258

Nantes, La Roche-sur-Yon

2026-04-30

Recruiting

HeartLogic™ in Patients With Heart Failure.

NCT07544771Heart Failure

Poitiers University Hospital

Not applicable

578

Amiens, Brest, Caen, Grenoble, Lille, Marseille, Nantes, Paris

2026-04-29

Recruiting

Study on the Prevention of Recidivism and the Consequences of Sexual Violence Suffered by Female Asylum Seekers in France

NCT07477314Sexual Violence, Refugee Health, Physical Health, Mental Health

Assistance Publique Hopitaux De Marseille

Observational

675

Bordeaux, Lyon, Marseille, Nantes, Paris, Toulouse

2026-04-29

Recruiting

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

NCT07499232Crohn Disease

DrugsRisankizumab·Guselkumab

Janssen Research & Development, LLC

Phase 3

530

Amiens, Clermont-Ferrand, Échirolles, Marseille, Nantes, Neuilly-sur-Seine, Nîmes, Paris

2026-04-21

Recruiting

Clindamycin as an Alternative to Vancomycin in Patients Undergoing Aortic Cardiac Surgery With Extracorporeal Circulation (ECC)

NCT07267013Aortic Surgery, Extracorporeal Circulation

DrugClindamycin

Nantes University Hospital

Phase 2

Nantes

2026-04-21

Recruiting

A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

NCT07226843Lymphoma, Non-Hodgkin's, Lymphoma, Diffuse Large B-Cell, Follicular Lymphoma

DrugRituximab

Eli Lilly and Company

Phase 1

460

Nantes, Paris, Pessac, Pierre-Bénite, Toulouse

2026-04-17

Recruiting

A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)

NCT07227311Multiple Myeloma

DrugsBelantamab mafodotin·Velcade·Carfilzomib·Pomalidomide

GlaxoSmithKline

Phase 2

200

Dunkirk, Nantes, Paris, Saint-Etienne

2026-04-15

Recruiting

Evaluation of a Customizable Antibiotic Stewardship Program Tailored to French Nursing Homes

NCT07246382Antibacterial Agents

University of Lorraine

Not applicable

Nantes, Vandœuvre-lès-Nancy

2026-04-14

Recruiting

DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy

NCT07472517Small Cell Lung Cancer (SCLC), Extensive-stage Small Cell Lung Cancer (ES-SCLC)

DrugsObrixtamig·Etoposide·Atezolizumab·Carboplatin

Boehringer Ingelheim

Phase 3

670

Angers, Bordeaux, Caen, Dijon, Nantes, Paris, Toulouse, Villefranche-sur-Saône

2026-04-13

Not yet open

Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.

NCT07527442Posterior Urethral Valves

University Hospital, Bordeaux

Phase 2

Besançon, Bordeaux, Limoges, Marseille, Montpellier, Nantes, Paris, Reims

2026-04-13

Recruiting

Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study

NCT07263113Periodontis, Atherosclerosis Cardiovascular Disease

Nantes University Hospital

Not applicable

206

Nantes

2026-04-10

Recruiting

Study to Assess the Efficacy and Safety of Rina-S Plus Standard of Care Compared to Standard of Care for Maintenance Treatment of Participants With Recurrent Platinum-sensitive Ovarian Cancer After Second-line (2L) Platinum-based Doublet Chemotherapy

NCT07225270Ovarian Cancer, Platinum-sensitive Ovarian Cancer, PSOC

DrugsRina-S·Bevacizumab

Genmab

Phase 3

544

Nantes, Saint-Cloud

2026-04-03

Recruiting

Effectiveness of a Four-Session Focal Shock Wave Therapy Protocol in Women With Vulvodynia

NCT07553715Vulvodynia

Nantes University Hospital

Observational

Nantes

2026-04-01

Recruiting

Reproducibility of Dental Bite Mark Overlay Analysis Using Digital 3D Models in Adult Participants

NCT07552051Forensic Dentistry, Bite Mark Analysis

Nantes University Hospital

Observational

Nantes

2026-04-01

Recruiting

Nuwiq Dosing and Outcomes In the ManagEment of Women/Girls With Haemophilia A Needing FVIII Treatment for Surgery

NCT05936580Hemophilia A

DrugNuwiq

Octapharma

Phase 4

Chambray-lès-Tours, Nantes, Stasbourg

2026-04

Not yet open

Tocilizumab in Chronic Inflammatory CPPD Disease

NCT07254637Calcium Pyrophosphate Deposition Disease

DrugTocilizumab

Assistance Publique - Hôpitaux de Paris

Phase 2

Lomme, Paris, Corbeil-Essonnes, Dijon, Nantes, Rennes, Saint-Etienne

2026-04

Recruiting

A Study to Assess the Effect of Surovatamig in Adult Participants With Antibody-mediated Kidney Disease

NCT07571746Primary Membranous Nephropathy

DrugSurovatamig

AstraZeneca

Phase 2

Bordeaux, Créteil, Lyon, Nantes, Nîmes

2026-03-28

Recruiting

Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2

NCT07235514Ischemic Stroke, Anterior Cerebral Circulation, General Anesthesia, Procedural Sedation

University Hospital, Clermont-Ferrand

Not applicable

958

Angers, Brest, Clermont-Ferrand, Lille, Lyon, Marseille, Montpellier, Nantes

2026-03-24

Recruiting

A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)

NCT07463183Colitis Ulcerative, Ulcerative Colitis

Merck Sharp & Dohme LLC

Phase 2

100

Lens, Nantes

2026-03-24

Recruiting

Nantes Bariatric Surgery Cohort

NCT06625762Obesity

Nantes University Hospital

Not applicable

300

Nantes

2026-03-23

Recruiting

Identification of Clinical, Genetic and Immunological Factors Involved in the Development of Severe Bacterial Infections in Pediatrics

NCT07111793Severe Bacterial Infections

Nantes University Hospital

Not applicable

1,401

Nantes, Brest, Lyon, Montpellier, Paris, Saint-Etienne

2026-03-18

Recruiting

Improving Patients' Adherence to Their Chronic Treatments by Implementing a Simple, Standardized and Redundant Message Delivered by Healthcare Professionals.

NCT06748118Chronic Disease, Therapeutic Adherence, Training Group, Sensitivity, Delivery Simple, Standardized & Redundant Message to Patient

Assistance Publique - Hôpitaux de Paris

Not applicable

1,210

Angers, Antibes, Issy-les-Moulineaux, Marseille, Nantes, Paris, Toulouse, Tours

2026-03-18

Recruiting

Preoperative Rehabilitation for Patient With an ACL Injury

NCT07411625Anterior Cruciate Ligament (ACL)

Nantes University Hospital

Not applicable

Nantes

2026-03-17

Recruiting

A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

NCT07387367Adenovirus Infections

SymBio Pharmaceuticals

Phase 3

180

Bordeaux, Lille, Nancy, Nantes, Paris, Rennes, Strasbourg

2026-03-17

Recruiting

A Multicentre Study of Wastewater and Antibiotic Resistance in Care Homes.

NCT07234331Antimicrobial Resistance

Nantes University Hospital

Observational

1,600

Angers, Nantes

2026-03-16

Not yet open

CABOTEGRAVIR/LENACAPAVIR DUAL LONG ACTING THERAPY (COHORT IMEA 074)

NCT07402044CABOTEGRAVIR, LENACAPAVIR

Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba

Observational

Argenteuil, Bordeaux, Garches, Levallois-Perret, Nantes, Nice, Paris, Tourcoing

2026-03-15

Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

NCT07221149Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

DrugsPumitamig·Folfox·Nivolumab

Bristol-Myers Squibb

Phase 2/3

690

Lyon Cedex08, Brest, Lille, Nantes, Poitiers, Marseille, Paris

2026-03-13

Recruiting

Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology

NCT07408375Solid Tumor (Excluding CNS)

Nantes University Hospital

Not applicable

560

Lyon, Nantes, Nîmes, Paris, Poitiers, Saint-Herblain, Villejuif

2026-03-13

Recruiting

A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation

NCT07412470Kidney Transplant Rejection

DrugsRabbit Anti thymocyte globulin·Frexalimab·Mycophenolate Mofetil·Tacrolimus

Sanofi

Phase 2/3

526

Bordeaux, Nantes, Paris, Toulouse, Tours

2026-03-13

Recruiting

Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.

NCT07299071Colonoscopy, Colorectal Neoplasms, Intestinal Polyps

University Hospital, Bordeaux

Not applicable

592

Bayonne, Brest, Carhaix-Plouguer, Charenton-le-Pont, Limoges, Marseille, Nantes, Nîmes

2026-03-13

Recruiting

New Care Pathway Using Automated Dynamic Laximetry

NCT07028476Knee Sprain, Automated Dynamic Laximetry (ADL), Care Pathway, MRI

University Hospital, Angers

Not applicable

Angers, Laval, Nantes

2026-03-10

Not yet open

Study With Tocilizumab in Combination With Venetoclax and Azacitidine Chemotherapy in Patients With Acute Myeloid Leukemia

NCT07392814Leukemia Acute Myeloid - AML

Nantes University Hospital

Phase 1

Nantes

2026-03-10

Recruiting

Assessment of the Impact of Oral Health Training for Caregivers on the Oral Health-related Quality of Life of Residents in Nursing Homes

NCT07399925Oral Health Training

Nantes University Hospital

Not applicable

Nantes

2026-03-06

Recruiting

Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care

NCT07246265Sickle Cell Disease, Glomerular Hyperfiltration, Sickle Cell Nephropathy, Vaso-Occlusive Crises

University Hospital, Tours

Not applicable

100

Tours, Créteil, Le Mans, Nantes, Orléans, Rennes

2026-03-05

Recruiting

Gut Microbiota Changes in Children Receiving Exclusive Enteral Nutrition With Compleat® Paediatric

NCT07816536Feeding and Eating Disorders of Childhood, Enteral Nutrition Dependence

Establishment for Children and Adolescents in the Nantes Region

Observational

Nantes

2026-03-04

Active, closed

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

NCT07288398Pulmonary Hypertension Associated With HFpEF

DrugTNX-103

Tenax Therapeutics, Inc.

Phase 3

540

Le Kremlin-Bicêtre, Montpellier, Nantes, Nice, Pau, Poitiers

2026-03-03

Recruiting

Multiparametric Ultrafast Ultrasound Biomarkers for Duchenne and Becker Muscular Dystrophies

NCT07378553Duchene Muscular Dystrophy, Becker Muscular Dystrophy

Nantes University Hospital

Observational

Nantes

2026-03-03

Not yet open

Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls

NCT07450235Pulpitis, Healthy

Université de Nantes

Observational

Nantes

2026-03-01

Not yet open

Upadacitinib in Giant Cell Arteritis (GCA) With Active Large-vessel Involvement.

NCT07354906Giant Cell Arteritis (GCA)

Groupe français d'étude des Maladies Inflammatoires de loeil

Observational

Aix-en-Provence, Caen, Dijon, Le Mans, Marseille, Melun, Montfermeil, Nantes

2026-03-01

Not yet open

Cognitive and Metacognitive Remediation in Addiction Treatment.

NCT07390877Alcohol Use Disorder

Nantes University Hospital

Not applicable

130

Blain, Bouguenais, Brest, Nantes, Quimper

2026-02-28

Recruiting

Halo Sign Vanishing Time After Steroids Outbreak in GCA Patients

NCT07060274Giant Cell Arteritis (GCA), Doppler Ultrasound

Centre Hospitalier le Mans

Not applicable

Le Mans, Angers, Caen, Dijon, La Rochelle, Nantes

2026-02-27

Recruiting

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

NCT07391657Relapsed Refractory Multiple Myeloma

DrugsAZD0120·Darzalex·Velcade·Carfilzomib

AstraZeneca

Phase 3

508

Lille, Nantes, Paris, Pierre-Bénite, Poitiers, Toulouse

2026-02-23

Recruiting

Study of Switching to Aflibercept 8 mg in Patients With Refractory or Dependent Exudative Age-related Macular Degeneration

NCT07423429Exudative Age-Related Macular Degeneration

DrugAflibercept

Nantes University Hospital

Observational

100

Nantes

2026-02-20

Recruiting

A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

NCT07202546HIV Infections

DrugsVH4524184·Dovato·Dolutegravir/Lamivudine

ViiV Healthcare

Phase 2

186

Bordeaux, Caen, Nantes, Nîmes, Paris

2026-02-11

Recruiting

New Simulation Care Pathway for Paediatric MRI Preparation

NCT07344753Magnetic Resonance Imaging (MRI)

Nantes University Hospital

Observational

114

Nantes

2026-02-11

Recruiting

Study of Alloknesia in Atopic Dermatitis

NCT06923202Atopic Dermatosis, Alloknesie

University Hospital, Brest

Observational

160

Angers, Brest, La Roche-sur-Yon, Lorient, Nantes, Rennes, Tours, Vannes

2026-02-10

Recruiting

Evaluation of the Analgesic Effect of Intramyometrial Botulinum Toxin Injection Via Hysteroscopy in Pelvic Pain Suggestive of Dysmenorrhea

NCT06995287Primary Dysmenorrhea, Chronic Pelvic Pain

DrugXeomin

Nantes University Hospital

Phase 3

222

Aix-en-Provence, Angers, Brest, Lille, Lyon, Nantes, Rennes

2026-02-09

Recruiting

Interaction Between Atypical Work Schedules and/or Idel Time at Work on At-risk Gambling Practices

NCT07421765Gambling, Shift Work, Addictive Behavior, Boredom

Centre Hospitalier Universitaire de Nīmes

Observational

Nantes, Nîmes

2026-02-05

Recruiting

Role of ACTG2 Variants in Smooth Muscle Determination and Function in Pediatric Intestinal Pseudo-obstruction.

NCT06687564PIPO

University Hospital, Grenoble

Not applicable

Montpellier, Nantes, Paris

2026-02-04

Recruiting

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

NCT07258511Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

400

Lille, Lyon, Nancy, Nantes, Paris, Pessac, Poitiers, Toulouse

2026-02-04

Recruiting

Stratification of Arrhythmic Risk and/or Heart Failure Risk in Patients With Hereditary Heart Disease

NCT07257289Hereditary Heart Diseases

Nantes University Hospital

Observational

1,000

Bordeaux, Brest, Clermont-Ferrand, Dijon, La Rochelle, Limoges, Montpellier, Nantes

2026-02-03

Recruiting

Evaluating the roLe of Multiplexed PET Imaging in the Detection and Staging of hepatocellulaR Carcinoma and gAstro-entero-pancreatic Tumors

NCT07178587Hepatocellular Carcinoma (HCC), Gastro-Entero-Pancreatic Tumors (GEPs)

Nantes University Hospital

Not applicable

Brest, Clichy, Nantes

2026-02-02

Recruiting

Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)

NCT07224360Sickle Cell Disease

CSL Behring

Phase 2

Nantes, Toulou

2026-02-02

Recruiting

COmparison of the Use of a PERforator Flap Versus Total Skin GRAft in the Management of Loss of Substance After Resection of Cutaneous Melanoma - Pilot Study

NCT07354152Stage II Cutaneous Melanoma

Nantes University Hospital

Observational

Nantes

2026-02-01

Not yet open

Multicenter Prospective Cohort on Esophageal Endoscopic Submucosal Dissection

NCT07343869Superficial Esophageal Cancer, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Barretts Esophagus With Dysplasia

Société Française d'Endoscopie Digestive

Observational

750

Nantes

2026-02-01

Recruiting

Identifying Electrocardiographic Markers to Determine Eligibility for the Implantation of a Subcutaneous Defibrillator.

NCT07157449Defibrillator, ECG

Nantes University Hospital

Observational

1,000

Nantes

2026-01-27

Recruiting

Pilot Study on the Adaptation and Tolerance of Essilor® Myopia-control Spectacle Lenses

NCT07340931Myopia

Nantes University Hospital

Observational

Nantes

2026-01-20

Recruiting

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

NCT07195695Non-small Cell Lung Cancer

DrugsZongertinib·Atezolizumab·Durvalumab·Nivolumab

Boehringer Ingelheim

Phase 3

400

Bron, Marseille, Nantes, Paris, Rennes, Strasbourg, Toulouse, Villejuif

2026-01-16

Recruiting

A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

NCT07185009Ulcerative Colitis

DrugDuvakitug

Sanofi

Phase 3

751

Amiens, Besançon, Créteil, La Tronche, Lille, Marseille, Nantes, Nice

2026-01-16

Recruiting

TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

NCT07190300Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

DrugsTulmimetostat·Prednisone/Prednisolone·Abiraterone·Darolutamide

Novartis Pharmaceuticals

Phase 1/2

181

Créteil, Lille, Nantes

2026-01-13

Not yet open

End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting

NCT07368010Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation

Nantes University Hospital

Not applicable

720

Nantes

2026-01-10

Not yet open

Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma

NCT07326033Systemic Scleroderma

DrugAdMSC

University Hospital, Toulouse

Phase 2

Bordeaux, Dijon, Montpellier, Nantes, Toulouse

2026-01

Not yet open

Impact on Mortality of Hospitalisation of a Patient in a Hospital Bed That Does Not Correspond to His Needs After a Visit to the Emergency Department

NCT07347847Emergency Department Patient

Rennes University Hospital

Observational

2,766

Angers, Le Mans, Nantes, Poitiers, Strasbourg, Toulouse, Tours

2026-01

Recruiting

A Study to Investigate Efficacy and Safety With SAR445399 in Adult Participants With Moderate to Severe Hidradenitis Suppurativa

NCT07225569Hidradenitis Suppurativa

Sanofi

Phase 2

144

Lille, Nantes, Paris, Rouen

2025-12-29

Recruiting

Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Procedure

NCT06780722Cardiac Arrest, Reanimation

Nantes University Hospital

Observational

Angers, Annecy, Avignon, La Roche-sur-Yon, Lille, Nantes, Orléans, Poitiers

2025-12-19

Recruiting

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

NCT07266831Human Immunodeficiency Virus Type 1 (HIV-1) Infection

DrugB/F/TAF

Merck Sharp & Dohme LLC

Phase 2/3

570

Bordeaux, Toulouse, Nantes, Lyon, Bobigny, Paris

2025-12-18

Not yet open

Evaluation of the NEOmom® Gastric Video Capsule for Gastric Cancer Screening

NCT07323186Stomach Cancer, Diagnosis, Endoscopy of Stomach (Procedure)

Nantes University Hospital

Not applicable

100

Nantes

2025-12-15

Recruiting

IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure

NCT07189078Acute Hypoxemic Respiratory Failure

University Hospital, Angers

Not applicable

200

Angers, Le Mans, Nantes, Orléans, Paris, Pointe à Pitre, Rennes, Tours

2025-12-13

Recruiting

MEthylphenidate in ADHD - Addiction(s) Comorbidity: Value of Adding a Cognitive Remediation Program to Improve Short- and Medium-term Therapeutic Response

NCT06906328ADHD-add

Nantes University Hospital

Not applicable

248

Brest, Quimper, Fleury-les-Aubrais, Tours, Bouguenais, Nantes

2025-12-11

Recruiting

A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia

NCT07144163Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 3

150

Angers, Bron, Nantes, Paris, Pessac, Vandœuvre-lès-Nancy

2025-12-11

Recruiting

Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody

NCT07285213Clostridioides Difficile Infection

AstraZeneca

Phase 2

230

Lyon, Montpellier, Nantes, Nîmes, Paris, Tours

2025-12-10

Active, closed

A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

NCT07107945Chronic Kidney Disease

DrugDapagliflozin

Boehringer Ingelheim

Phase 3

135

Bron, Marseille, Nantes, Paris, Toulouse

2025-12-09

Recruiting

A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI in Adult Participants With PSMA-positive mCRPC

NCT07226986PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC) With Prior Exposure to One Prior ARPI Who Are Candidates for Taxane-based Chemotherapy

DrugsAbiraterone·Enzalutamide

Novartis Pharmaceuticals

Phase 1/2

123

Bordeaux, Clermont-Ferrand, Nantes, Villejuif

2025-12-05

Recruiting

A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)

NCT07241390Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease

DrugOrforglipron

Eli Lilly and Company

Phase 3

7,140

Bois-Guillaume, Clermont-Ferrand, La Tronche, Le Coudray, Lyon, Mulhouse, Nantes, Nice

2025-12-01

Recruiting

A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

NCT06847542Neovascular Age-related Macular Degeneration

DrugRanibizumab

Hoffmann-La Roche

Phase 3

250

Nantes, Lyon, Montauban, Paris, Poitiers, Strasbourg

2025-11-27

Recruiting

Trial Evaluating the Benefit of Left Bundle Branch Area Stimulation Compared With Conventional Pacing in Post-TAVI Atrioventricular Atrioventricular Block

NCT07236489Atrioventricular Block, Pacemaker

Nantes University Hospital

Not applicable

266

Brest, Rennes, Tours, Nantes, Clermont-Ferrand, Rouen, Poitiers

2025-11-25

Recruiting

Momelotinib in VEXAS Syndrome

NCT07098936VEXAS Syndome, Myelo Dysplastic Syndrome

Groupe Francophone des Myelodysplasies

Phase 2

Angers, Clermont-Ferrand, Lille, Nantes, Paris, Pessac, Pierre-Bénite, Rennes

2025-11-25

By invitation

Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

NCT07256392Chronic Spontaneous Urticaria

DrugBarzolvolimab

Celldex Therapeutics

Phase 3

1,370

Nantes, Nice

2025-11-25

Recruiting

A Platform Study in Non-Small Cell Lung Cancer (NSCLC)

NCT06996782Advanced or Metastatic Non-small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Nab-paclitaxel·Pemetrexed

AstraZeneca

Phase 1/2

152

Bordeaux, Dijon, Limoges, Marseille, Nantes, Nice, Paris

2025-11-24

Active, closed

Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen

NCT07087054Carcinoid Syndrome, Carcinoid, Carcinoid Tumor, Carcinoid Tumor of Ileum

Crinetics Pharmaceuticals Inc.

Phase 3

141

Chambray-lès-Tours, Clichy, Marseille, Nantes, Nice, Paris, Pessac, Toulouse

2025-11-19

Recruiting

A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

NCT06948448Colorectal Cancer

DrugsONO-4578·Leucovorin·Opdivo·Adrucil

Ono Pharmaceutical Co., Ltd.

Phase 2

144

Besançon, Pessac, Nantes, Marseille, Paris, Lyon, Poitiers

2025-11-18

Recruiting

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

NCT07228832Metastatic Colorectal Cancer (CRC)

DrugsIvonescimab·Leucovorin·Adrucil·Oxaliplatin

Summit Therapeutics

Phase 3

600

Bordeaux, Lille, Lyon, Marseille, Montpellier, Nantes, Nice, Paris

2025-11-18

Recruiting

High-throughput Omic Technology for Identification of Biomarkers of Relapsing Acute Disseminated Encephalomyelitis in Immune Cell Network

NCT06863974Acute Disseminated Encephalomyelitis, Encephalitis Autoimmune

University Hospital, Angers

Not applicable

Angers, Brest, Le Kremlin-Bicêtre, Montpellier, Nantes, Paris, Rennes, Tours

2025-11-16

Recruiting

Durvalumab and Tremelimumab With or Without Hepatic Arterial Infusion of Chemotherapy in Hepatocellular Carcinoma

NCT06904170Hepatocellular Carcinoma

DrugsHAIC·Tremelimumab·Durvalumab·Lenvatinib

UNICANCER

Phase 2/3

196

Bordeaux, Clichy, Dijon, Marseille, Montpellier, Nantes, Paris, Poitiers

2025-11-14

Active, closed

A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)

NCT07074886Multiple Sclerosis

Hoffmann-La Roche

Phase 2

193

Nantes, Nîmes

2025-11-13

Recruiting

A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to < 12 Years Old) With Nonsegmental Vitiligo

NCT06804811NonSegmental Vitiligo

DrugRuxolitinib

Incyte Corporation

Phase 3

250

Argenteuil, Bordeaux, Créteil, Lyon, Nantes, Nice, Paris, Reims

2025-11-13

Recruiting

Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia

NCT06743529Ventilator-Associated Pneumonia (VAP)

Nantes University Hospital

Not applicable

686

Angers, Angoulème, Argenteuil, Nantes, Arles, Avignon, Belfort, Bordeaux

2025-11-11

Recruiting

Effect of Early Dexamethasone on Major Complications and All-cause Mortality in Severe Burns

NCT06968559Severe Burns

DrugDexamethasone

Nantes University Hospital

Phase 3

478

Chambray-lès-Tours, Lille, Lyon, Marseille, Metz, Montpellier, Nantes, Paris

2025-11-07

Recruiting

TOETVA Technique Compared With Anterior Cervical Thyroidectomy (AC) in Terms of Efficacy and Safety

NCT07055191Lobectomy, Thyroidectomy

University Hospital, Lille

Not applicable

616

Bobigny, Levallois-Perret, Lille, Limoges, Nantes, Paris, Pierre-Bénite, Poitiers

2025-11-07

Recruiting

Definition of Sub-phenotypes of Pneumonia Based on the Respiratory Microbiome Composition to Predict Microbial and Clinical Treatment Failures

NCT06916481Community Acquired or Acquiring Hospital Acquired Pneumonia

Assistance Publique - Hôpitaux de Paris

Observational

300

Clichy, Nantes, Paris

2025-11-06

Recruiting

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

NCT07015242Lymphoma

DrugsProcarbazine·Liso-cel·Lisocabtagene maraleucel·Calcium folinate

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 2

Nice, Nantes, Pierre-Bénite, Dijon, Lille, Marseille, Montpellier, Paris

2025-11-06

Recruiting

Treated Umbilical Vein Allograft (UVT) Versus Autologous Fascial Pubovaginal Sling in the Treatment of Female Stress Urinary Incontinence

NCT06678984Stress Urinary Incontinence in Women

TBF Genie Tissulaire

Phase 3

Clermont-Ferrand, La Tronche, Nantes, Paris, Pierre-Bénite, Rouen, Strasbourg, Toulouse

2025-11-06

Recruiting

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

NCT07007065Neovascular Age-related Macular Degeneration

DrugSurabgene Lomparvovec

AbbVie

Phase 3

561

Nice, Lyon, Bordeaux, Nantes, Écully, Créteil, Marseille, Paris

2025-11-05

Recruiting

Transcriptomic Approach for the Identification and Prioritization of Genome Variants in Neurodevelopmental Disorders With Malformation

NCT06762678Neurodevelopmental Disorders and Developmental Abnormalities

University Hospital, Angers

Not applicable

Angers, Brest, Le Mans, Nantes, Rennes, Tours, Vannes

2025-11-04

Recruiting

Study Assessing PET Imaging With Zirconium-labelled Girentuximab in Patients With HCC, BTC or NEN

NCT06735560Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc), Neuroendocrine Tumors

Nantes University Hospital

Not applicable

Nantes, Paris

2025-11-04

Not yet open

Benefit on Chronic Pain of Early Screening and Management of Patients With Persistent Postoperative Pain at 3 Months

NCT07160595Chronic Postoperative Pain

Fondation Hôpital Saint-Joseph

Not applicable

2,052

Boussy-Saint-Antoine, Lyon, Nantes, Paris, Saint-Cloud, Saint-Etienne, Suresnes, Toulouse

2025-11

Recruiting

Cardiopediatric Home Monitoring Tool

NCT06741189Congenital Heart Defect

Nantes University Hospital

Not applicable

186

Nantes

2025-10-30

Not yet open

PErioperative CISGEM + Rilvegostomig in High-Risk Resectable Intra Hepatic CholangioCarcinoma

NCT07128290Intrahepatic Cholangiocarcinoma (Icc)

DrugRilvegostomig

Federation Francophone de Cancerologie Digestive

Phase 2

Caen, Dijon, Grenoble, Limoges, Marseille, Nancy, Nantes, Poitiers

2025-10-30

Recruiting

Protocolized Receptive Music Intervention to Reduce Care Refusal in Nursing Home Residents With Major Neurocognitive Disorders

NCT07730957Dementia, Cognitive Dysfunction, Psychomotor Agitation, Burnout, Professional

LNA SANTE

Not applicable

Amiens, Garches, La Celle-Saint-Cloud, La Ferté-sous-Jouarre, Nantes, Pacé, Pessac, Saint-Rogatien

2025-10-30

Recruiting

Clinical Investigation Measuring the Long Term Clinical Performance and Safety of Biodentine™ XP in Patients Treated for Coronal Restorative or Endodontic Dental Indications.

NCT06955429Dental Restoration, Permanent, Dental Restorations, Endodontic Treatment

Septodont

Observational

275

Lyon, Nantes, Paris, Rennes

2025-10-23

Recruiting

A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)

NCT07221500Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)

DrugBexobrutideg

Nurix Therapeutics, Inc.

Phase 2

100

Nantes

2025-10-15

Recruiting

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

NCT07196722Crohn Disease

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 2/3

1,092

Bayonne, Clermont-Ferrand, Créteil, Échirolles, Lille, Montfermeil, Montpellier, Nantes

2025-10-03

Recruiting

Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary Syndromes

NCT07102628Acute Coronary Syndrome

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

300

Chambray-lès-Tours, Montpellier, Nantes, Pessac, Poitiers

2025-10-03

Recruiting

Early Assessment of Quadriceps Muscle Recovery by Dynamometry and 3D Ultrasound in Intensive Care Patients Under Invasive Mechanical Ventilation

NCT07069959Intensive Care Unit Acquired Weakness, Muscle Weakness

Nantes University Hospital

Observational

100

Nantes

2025-10-03

Recruiting

HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

NCT05745714Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory

DrugsRuxolitinib·Cytarabine·Venetoclax·Dexamethasone

Princess Maxima Center for Pediatric Oncology

Phase 1/2

Bordeaux, Lille, Lyon, Marseille, Nantes, Paris

2025-10-01

Recruiting

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

NCT07184931Crohn's Disease

DrugDuvakitug

Sanofi

Phase 3

980

Amiens, Saint-Etienne, Besançon, Créteil, La Tronche, Lille, Marseille, Nantes

2025-10-01

Not yet open

LIDOCRIT : Effect of Continuous Intravenous LIDOcaine on Discomfort in Postoperative CRITical Care Inpatients

NCT07043023Post-surgery Critical Incare

DrugLidocaine

Rennes University Hospital

Phase 4

246

Angers, Brest, Chartres, Nantes, Poitiers, Rennes, Saint-Nazaire, Tours

2025-10-01

Recruiting

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

NCT07041099Sjögren, Sjogren Disease, Sjogren's Syndrome

DrugCLN-978

Cullinan Therapeutics Inc.

Phase 1

Brest, Le Kremlin-Bicêtre, Nantes, Saint-Priest-en-Jarez, Strasbourg

2025-10-01

Not yet open

Periodontal Follow-up and Glycemy in Patients With Type 2 Diabetes

NCT07165171Periodontal Disease

Hospices Civils de Lyon

Not applicable

516

Ivry-sur-Seine, Lille, Lyon, Nantes, Rennes, Saint-Victor-de-Cessieu, Strasbourg, Toulouse

2025-10-01

Recruiting

Study of a Patient Cohort Following Digestive Surgical Care After the Implementation of a Telemonitoring and Tele-coordination Platform for Medical, Paramedical, and Social Management

NCT07186738Telemonitoring

Nantes University Hospital

Observational

250

Nantes

2025-10-01

Recruiting

HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

NCT05751044Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory

DrugsDasatinib·Cytarabine·Venetoclax·Dexamethasone

Princess Maxima Center for Pediatric Oncology

Phase 1/2

Bordeaux, Lille, Lyon, Marseille, Nantes, Paris

2025-10-01

Not yet open

Efficacy of Live Online Course Mindfulness Program on Perceived Fatigue in Hemodialysis Patients

NCT07054112Chronic Kidney Disease Requiring Hemodialysis

University Hospital, Tours

Not applicable

Angers, Bayonne, Bordeaux, Chartres, Gradignan, La Roche-sur-Yon, Nantes, Orléans

2025-09-30

Recruiting

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

NCT07007312Acute Myeloid Leukemia (AML)

DrugsZiftomenib·Ara-C·Daunorubicin·Venclexta

Kura Oncology, Inc.

Phase 3

1,300

Clermont-Ferrand, Pierre-Bénite, Saint-Priest-en-Jarez, Mulhouse, Vandœuvre-lès-Nancy, Nantes, Pessac, Lille

2025-09-26

Recruiting

Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia (ATHERO-FH Study)

NCT06960902Familial Hypercholesterolemias, Atherosclerotic Cardiovascular Disease (ASCVD)

Nantes University Hospital

Not applicable

600

Dijon, Lille, Lyon, Marseille, Nantes, Paris, Rennes, Strasbourg

2025-09-25

Recruiting

[68Ga]Ga-PSMA PET/CT in Hepatocellular Carcinoma: Impact of Multiparametric Dynamic Whole-body Imaging and Kinetic Modeling.

NCT06999837HCC - Hepatocellular Carcinoma

Nantes University Hospital

Not applicable

Clichy, Nantes

2025-09-23

Recruiting

Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

NCT07116967Plaque Psoriasis

DrugsUstekinumab·Deucravacitinib

Bristol-Myers Squibb

Phase 3

3,040

Nantes, Nice, Rennes, Saint-Pierre (La Réunion)

2025-09-22

Recruiting

Critical Care Optimized Pediatric and Neonatal Quantitative Neuromonitoring

NCT06726408Neonatal Intensive Care Unit

Nantes University Hospital

Observational

120

Nantes

2025-09-16

Recruiting

Pilot Study Assessing the Feasibility and Impact of a Remote Adapted Physical Activity Program on Quality of Life in Patients With Inflammatory Bowel Disease (IBD)

NCT07191106Inflammatory Bowel Disease (IBD), Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis)

Raincy Montfermeil Hospital Group

Not applicable

Montfermeil, Nantes

2025-09-15

Recruiting

A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06973187Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsTacabrutideg·Pirtobrutinib

BeOne Medicines

Phase 3

500

Bordeaux, ClermontFerrand, Nantes, Paris, Rouen, Toulouse, Tours, VandoeuvrelesNancy

2025-09-04

Recruiting

oPtic Nerve Sheath Evaluation in gianT Cell aRtheritis by UltraSound

NCT07001059Giant Cell Arteritis (GCA)

Hôpital NOVO

Not applicable

190

Aix-en-Provence, Brest, Caen, Dijon, Nantes, Paris, Pontoise, Tours

2025-09-04

Recruiting

Pressure-Volume Loop Assessment in Valvular Heart Disease

NCT07112391Heart Failure, Structural Heart Disease, Interventional Cardiology

Nantes University Hospital

Observational

Nantes

2025-09-04

Recruiting

Biomedical Innovation for Facial Bone Reconstruction in Oncology: BIOFACE PASS a Medico-economic Study Describing the Standard Pathway of Patients Treated by Free Bone Flap

NCT06771336Head and Neck Cancers

University Hospital, Toulouse

Observational

200

Amiens, Lille, Lyon, Montpellier, Nantes, Nice, Rouen, Toulouse

2025-09-03

Recruiting

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

NCT07157774Elevated Lp(a), Atherosclerotic Cardiovascular Disease (ASCVD)

Eli Lilly and Company

Phase 3

10,450

Dijon, Epagny Metz-Tessy, La Tronche, Lille, Lyon, Nantes, Nice, Paris

2025-09-02

By invitation

Effects of Eccentric Training at Long Muscle Length on Functional Capacities of Elderly Adults

NCT06953258Eccentric Exercise, Home-based Training, Elderly Adults

Robin Souron

Not applicable

Nantes

2025-09-01

Not yet open

Physical Activity Oxidative Stress and Inflammation With Ageing

NCT06980896Inflammation, Oxydative Stress, Sarcopenia, Older Patient

Nantes University Hospital

Observational

Nantes

2025-09-01

Not yet open

Long-term Evaluation of Percutaneous Endoscopic Caecostomy in Refractory Constipation

NCT07160192Constipation, Refractory

Nantes University Hospital

Observational

Nantes

2025-09-01

Recruiting

Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List

NCT06868797Heart Failure

Central Hospital, Nancy, France

Not applicable

103

Bron, La Tronche, Montpellier, Nantes, Paris, Pessac, Rennes, Rouen

2025-08-29

Recruiting

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

NCT06925321Invasive Mold Infections

DrugFosmanogepix

Basilea Pharmaceutica

Phase 3

234

Nantes, Paris, Rennes

2025-08-26

Active, closed

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

NCT07018713Chronic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

808

Clermont-Ferrand, La Tronche, Nantes

2025-08-21

Active, closed

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine

NCT07018700Episodic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

997

Clermont-Ferrand, La Tronche, Nantes

2025-08-21

Recruiting

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)

NCT06911502Follicular Lymphoma

DrugsPrednisone/Prednisolone·Golcadomide·Bendamustine·Vincristine

Celgene

Phase 3

400

Pessac, Saint-Cloud, Montpellier, Nantes, Lille, Pierre-Bénite, Paris, Toulouse

2025-07-28

Recruiting

Health-economic Assessment of Robot-assisted Bariatric Surgery

NCT06858761Obesity

Hospices Civils de Lyon

Not applicable

482

Bordeaux, Dijon, Grenoble, Jossigny, Lille, Lyon, Marseille, Nantes

2025-07-25

Recruiting

Impact of Thymectomy on Immunity in Infants After Cardiac Surgery

NCT07019857Congenital Heart Defects, Thymectomy, Immunological Deficiency Syndrome

Nantes University Hospital

Not applicable

Nantes

2025-07-25

Recruiting

Study to Evaluate the Safety, Pharmacology and Efficacy of WIN378 in Adults With Moderate or Severe Asthma

NCT07120503Asthma

DrugWIN378

Windward Bio

Phase 2

600

Pessac, Dijon, Montpellier, La Tronche, Nantes

2025-07-24

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

NCT06953960Multiple Myeloma

DrugsEtentamig·Pomalidomide·Daratumumab·Dexamethasone

AbbVie

Phase 1/2

325

Montpellier, Poitiers, Toulouse, Nantes, Paris

2025-07-23

Recruiting

Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

NCT07064759Neovascular Age-Related Macular Degeneration (nAMD)

DrugsEYLEA (aflibercept)·4D-150 IVT

4D Molecular Therapeutics

Phase 3

480

Nice, Marseille, Nantes

2025-07-22

Recruiting

Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children

NCT07522580Circulatory Failure, Shock State, Fluid Therapy

University Hospital, Bordeaux

Observational

Le Plessis-Robinson, Montpellier, Nantes, Pessac

2025-07-22

Recruiting

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

NCT06943755Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)

DrugsZanzalintinib·Everolimus

Exelixis

Phase 2/3

440

Caen, Clichy, Lille, Lyon, Marseille, Montpellier, Nantes, Rennes

2025-07-21

Recruiting

Evaluation of Frailty in Patients With Fibrosing Interstitial Lung Diseases: Prognostic and Therapeutic Impact

NCT07004595Sarcopenia

Nantes University Hospital

Observational

100

Nantes

2025-07-20

Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

NCT06765109Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive

DrugsNeladalkib·Alectinib

Nuvalent Inc.

Phase 3

450

Angers, Bordeaux, Caen, Lyon, Marseille, Montpellier, Nantes, Paris

2025-07-17

Recruiting

A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy

NCT06963827Kidney Disease

DrugMezagitamab

Takeda

Phase 3

347

Créteil, Bordeaux, Limoges, Montpellier, Nantes, Paris

2025-07-15

Recruiting

Nutritional Oleic Acid Modulation of adIpose Cholesterol Metabolism in Patients Living With Obesity

NCT07027033Obesity, Visceral Adipose Tissue, White Adipose Tissue Inflammation, Subcutaneous Adipose Tissue

Nantes University Hospital

Not applicable

Nantes

2025-07-15

Recruiting

ELEVATE-HFpEF Clinical Study

NCT06678841Heart Failure With Preserved Ejection Fraction (HFpEF)

Medtronic Cardiac Rhythm and Heart Failure

Not applicable

700

Besançon, Clermont-Ferrand, Nantes, Toulouse

2025-07-09

Recruiting

Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis

NCT06820450Endometriosis

Nantes University Hospital

Observational

135

Nantes

2025-07-01

Recruiting

Ethical Issues of Using Gene Therapy in the Treatment of AMD

NCT07004361Exudative Age-related Macular Degeneration

Nantes University Hospital

Observational

Nantes

2025-07-01

Recruiting

Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome

NCT06889974Renal Replacement Therapy for Acute Kidney Injury in ICU

University Hospital, Bordeaux

Observational

800

Angers, Bordeaux, Brest, Limoges, Nantes, Orléans, Pau, Rennes

2025-07-01

Recruiting

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

NCT07037459Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction, Obesity

DrugMaridebart cafraglutide

Amgen

Phase 3

5,056

Amiens, Béziers, Bron, Dijon, Lille, Montpellier, Nantes, Nice

2025-06-25

Active, closed

Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

NCT06959225Hidradenitis Suppurativa

DrugRuxolitinib

Incyte Corporation

Phase 3

580

Bordeaux, Brest, Nantes, Nice, Paris

2025-06-23

Recruiting

A Phase 2 Study to Assess STP938 (Dencatistat) as a Monotherapy in Adults With High Risk Essential Thrombocythaemia - The VECTRA Trial

NCT06786234Essential Thrombocythaemia

DrugSTP938

Step Pharma, SAS

Phase 2

Poitiers, Brest, Marseille, Nantes, Nice, Nîmes, Paris, Villejuif

2025-06-18

Active, closed

Dose Escalation Trial of CD40.Pan.CoV Vaccine, Adjuvanted or Not, as a Booster in Adult Healthy Volunteers

NCT07113106Healthy Volunteers

ANRS, Emerging Infectious Diseases

Phase 1/2

Caen, Clermont-Ferrand, Créteil, Lille, Nantes, Paris

2025-06-18

Active, closed

Prediction of Lung Transplant Outcome

NCT07356752Graft Dysfunction, Lung Transplantation, Chronic Lung Allograft Dysfunction (CLAD), Chronic Rejection of Lung Transplant

Hopital Foch

Not applicable

4,200

Paris, Strasbourg, Talence, Grenoble, Le Plessis-Robinson, Lyon, Nantes, Suresnes

2025-06-17

Recruiting

Impact of Ambulatory Continuous Monitoring Using Remote Monitoring Medicine Within Patient's Care Pathway Following Colorectal Surgery (CONTACT-GRECCAR 21)

NCT06850688Colorectal Surgery, Readmission

Nantes University Hospital

Not applicable

362

Angers, Bordeaux, Grenoble, Lyon, Marseille, Nantes, Paris, Rennes

2025-06-17

Recruiting

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

NCT06943872Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsSonrotoclax·Venclexta·Obinutuzumab·Venetoclax

BeOne Medicines

Phase 3

630

ClermontFerrand, Nantes, Paris, PierreBenite, Reims, Rennes Cedes, Rouen, Toulouse

2025-06-11

Recruiting

Study of Psychosocial and Contextual Determinants of General Practitioners' Management of Burnout

NCT06811181Burnout

Nantes University Hospital

Observational

410

Nantes

2025-06-05

Active, closed

A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy

NCT06821542Chronic Graft-versus-host-disease

DrugAxatilimab

Incyte Corporation

Phase 3

Amiens, Caen, Lille, Marseille, Nantes, Nice, Paris, Pessac

2025-06-04

Recruiting

Evaluation of the Acceptability and Therapeutic Maintenance After Substitution of Ustekinumab With a Biosimilar

NCT07077681Crohn Disease (CD)

EG Labo

Observational

246

Amiens, Bayonne, Besançon, Brest, Montpellier, Nantes, Neuilly-sur-Seine, Pierre-Bénite

2025-06-02

Recruiting

Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

NCT06784752Somatostatin Receptor Positive (SSTR+), Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)

DrugOctreotide LAR

Novartis Pharmaceuticals

Phase 3

240

Bron, Clichy, Montpellier, Nantes, Pessac, Toulouse

2025-05-30

Recruiting

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

NCT07012395Ulcerative Colitis, Inflammatory Bowel Diseases, Colitis, Colitis, Ulcerative

DrugsSPY001·SPY002·SPY003

Spyre Therapeutics, Inc.

Phase 2

645

Marseille, Nantes, Nice, Pierre-Bénite, Saint-Etienne

2025-05-27

Recruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

NCT06941272Malignant Neoplasm

DrugPatritumab deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

Bordeaux, Marseille, Nantes, Lyon, Paris

2025-05-26

Recruiting

Evaluation of the Impact of Electronic Monitoring on Patient Compliance in Hematology

NCT06713811Hemopathies

Private Hospital of Confluent, France

Not applicable

110

Amiens, Morlaix, Nantes

2025-05-22

Recruiting

Effectiveness of PKP vs DSAEK in Terms of 2-year Postoperative Visual Acuity in Advanced BPK

NCT06818747Bullous Pseudophakic Keratopathy, Penetrating Keratoplasty

Centre Hospitalier Régional Metz-Thionville

Not applicable

334

Besançon, Bordeaux, Brest, Metz, Nantes, Paris, Saint-Etienne, Strasbourg

2025-05-21

Active, closed

Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa

NCT06940830Hemophilia A

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 4

252

Bordeaux, Marseille, Montpellier, Nantes, Paris, Rennes, Rouen

2025-05-21

Recruiting

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

NCT06876649Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma

DrugPirtobrutinib

Eli Lilly and Company

Phase 4

787

Nantes

2025-05-20

Recruiting

A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

NCT06876662Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma

DrugPirtobrutinib

Eli Lilly and Company

Phase 4

279

Nantes

2025-05-20

Active, closed

A Study to Assess the Safety and Effectiveness of the UrOActive® Artificial Urinary sPHincter (AUS)

NCT06968741Stress Urinary Incontinence (SUI)

UroMems SAS

Not applicable

140

Lille, Marseille, Nantes, Paris, Pierre-Bénite, Rennes, Rouen, Suresnes

2025-05-19

Recruiting

Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

NCT06830798Delayed Graft Function, DGF, Kidney Transplant

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Phase 3

450

Créteil, La Rochelle, La Tronche, Montpellier, Nantes, Paris, Toulouse

2025-05-19

Recruiting

A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

NCT06522737Lymphoma

DrugsDuvelisib·Bendamustine·Gemcitabine

SecuraBio

Phase 3

124

Rouen, Villejuif, Caen, Clermont-Ferrand, Montpellier, Nantes, Paris, Pessac

2025-05-19

Recruiting

Evaluation of the Efficacy of Dissociation-Focused Cognitive Behavior Therapy

NCT06917209Dissociative Disorder

University Hospital, Tours

Not applicable

140

Angers, Lille, Montpellier, Nantes, Orléans, Strasbourg, Tours

2025-05-16

Recruiting

The Impact of Paramedic Training in Simulation on the Experience of Patients Treated for Malignant Brain Tumors in Neurosurgery (IPSIMANON)

NCT06962215Brain Tumor Adult

University Hospital, Brest

Not applicable

250

Brest, Amiens, Angers, Bordeaux, Marseille, Nantes, Nice, Rouen

2025-05-15

Recruiting

Feasibility and Efficacy of Cognitive-Behavioral Therapy for Patients With ADHD/Behavioral Addiction Comorbidity

NCT06797726ADHD, Behavioral Addiction

University Hospital, Tours

Not applicable

Brest, Nantes, Tours

2025-05-13

Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

NCT06921785Hepatocellular Carcinoma

DrugsRilvegostomig·Tremelimumab·Atezolizumab·Bevacizumab

AstraZeneca

Phase 3

1,220

Clichy, Lille, Lyon, Montpellier, Nantes, Nice, Pessac, Rennes

2025-05-06

Active, closed

WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

NCT06967805Idiopathic Pulmonary Fibrosis

Mediar Therapeutics

Phase 2

168

Nantes, Nice, Rennes

2025-05-05

Recruiting

A Pilot Study to Assess the Feasibility and Acceptability of Newborn Screening Using in Silico Panel-based Solo Genome Sequencing in France

NCT06875089Newborn Screening Programmes for Rare Diseases

Centre Hospitalier Universitaire Dijon

Observational

5,000

Angers, Besançon, Dijon, Nantes, Rennes

2025-05-05

Recruiting

Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients

NCT06447480Acne Vulgaris

DrugIsotretinoin

Centre Hospitalier Universitaire de Nice

Phase 3

420

Nice, Bordeaux, Nantes, Rouen, Sainte-Maxime, Argenteuil, Brest, Cenon

2025-04-29

Active, closed

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

NCT06914895Type 1 Diabetes, Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

905

Caen, Corbeil-Essonnes, Le Creusot, Lyon, Marseille, Montpellier, Nantes, Pontoise

2025-04-25

Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

NCT06820463Metastatic Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Panitumumab·Fluorouracil·Leucovorin

AbbVie

Phase 2

390

Lille, Poitiers, Nantes, Paris

2025-04-24

Recruiting

Study of Re-treatment With [177Lu]Lu-PSMA in Men With Metastatic Castration Resistance Prostate Cancer

NCT06866938Metastatic Castration-resistant Prostate Cancer

DrugLu-PSMA

Hospices Civils de Lyon

Phase 2

Bordeaux, Brest, Bron, Caen, Clermont-Ferrand, Grenoble, Lyon, Nantes

2025-04-11

Recruiting

Impact of an Early Warning System on the Prognosis of Patients With Hematological Malignancies Receiving Intensive Chemotherapy With or Without Hematopoietic Cell Transplantation.

NCT06409767Leukemia, Lymphoma, Multiple Myeloma

University Hospital, Angers

Not applicable

2,224

Amiens, Angers, Besançon, Brest, Nancy, Nantes, Poitiers, Saint-Etienne

2025-04-10

Recruiting

Evaluation of the Inflammation-based Index as a Predictive Marker of Clinical and Radiological Response in Patients Treated With Lu-177 Oxodotreotide for Intestinal Neuroendocrine Tumour

NCT06876532Intestinal Neuroendocrine Tumor

Institut Claudius Regaud

Not applicable

150

Angers, Bordeaux, Caen, Lille, Lyon, Marseille, Montpellier, Nantes

2025-04-07

Recruiting

Antenatal Investigation of Fetuses With Complex Congenital Heart Defects Using multiOMICS

NCT06705543Congenital Heart Disease

University Hospital, Bordeaux

Not applicable

Bordeaux, Nantes

2025-04-01

Not yet open

Financial Incentives and Weight Loss in Failed Bariatric Surgery

NCT06910735Obesity, Obesity Recidivism

Assistance Publique - Hôpitaux de Paris

Not applicable

264

Bobigny, Colombes, Créteil, Marseille, Nantes, Orléans, Paris, Poitiers

2025-04

Recruiting

Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode

NCT05384392First-episode Psychosis

DrugBlood sample

University Hospital, Brest

Not applicable

217

Angers, Brest, Nantes, Rennes, Tours

2025-03-27

Recruiting

Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms

NCT06689410Aneurysm, Brain Aneurysm, Congenital Disease

Nantes University Hospital

Not applicable

1,100

Nantes, Amiens, Angers, Besançon, Bordeaux, Brest, Caen, Clermont-Ferrand

2025-03-25

Recruiting

Metabolic Fluid Responsiveness in Children

NCT07255469Circulatory Failure / Shock State, Fluid Therapy

University Hospital, Bordeaux

Observational

110

Bron, Lille, Marseille, Nantes, Paris, Pessac, Toulouse, Saint-Denis

2025-03-21

Recruiting

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

NCT06819007Ovarian Cancer

DrugsTrastuzumab deruxtecan·Bevacizumab

Daiichi Sankyo

Phase 3

582

Bordeaux, Dijon, Lille, Lyon, Montpellier, Nantes, Paris, Rennes

2025-03-19

Recruiting

Study of Sleep Disorders in Prodromal and Definite Parkinsons Disease

NCT06582121Parkinson Disease, REM Sleep Behavior Disorder (iRBD)

Assistance Publique - Hôpitaux de Paris

Not applicable

457

Clermont-Ferrand, Lille, Lyon, Nantes, Nîmes, Paris

2025-03-18

Recruiting

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

NCT06376162Relapsed/Refractory KMT2A-r Acute Leukemia, Relapsed/Refractory NUP98-r Acute Leukemia, Relapsed/Refractory NPM1-m Acute Leukemia

DrugsZiftomenib·Cytarabine·Fludarabine

PedAL BCU, LLC

Phase 1

Nantes, Paris

2025-03-18

Active, closed

The Effect of Hedia Diabetes Assistant on TiMe-in-range in People With Type 1 Diabetes and Sub-Optimal Glycemic Control in France - A Randomised Controlled Trial.

NCT06819306Type 1 Diabetes Mellitus (T1DM)

Hedia ApS

Not applicable

154

Angers, Lyon, Nantes, Nîmes, Paris, Poitiers

2025-03-17

Recruiting

Enabling Women With Parkinson's Disease to Identify and Better Manage Hormonal Triggers of Parkinsonian Symptoms

NCT06582212Digital Technology, Mobile Application, Motor Fluctuations, Oestrogen

University Hospital, Grenoble

Not applicable

100

Grenoble, Nantes, Rennes, Toulouse

2025-03-12

Recruiting

A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy

NCT06854640Sepsis, Coagulopathy

DrugBAY3389934

Bayer

Phase 1

Tours, Strasbourg, Limoges, Angers, La Roche-sur-Yon, Nantes, Garches

2025-03-12

Recruiting

Microbiota Modification for Immuno-oncology in Hepatocellular Carcinoma

NCT06551272Hepatocellular Carcinoma

DrugEXL01

Center Eugene Marquis

Phase 2

Bobigny, Bordeaux, Clichy, Nantes, Rennes, Villejuif

2025-03-12

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

NCT06615479Relapsed or Refractory Multiple Myeloma (RRMM)

DrugsArlo-cel·Carfilzomib·Pomalidomide·Daratumumab

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 3

440

Lille, Nantes, Pierre-Bénite, Créteil, Paris

2025-03-12

Recruiting

Contribution of Point of Care Ultrasound by the Emergency Physician to Rule Out the Small Bowel Obstruction: a Diagnostic, Multicenter Study

NCT06803628Small Bowel Obstruction

Nantes University Hospital

Observational

667

Clermont-Ferrand, Eaubonne, La Roche-sur-Yon, Luçon, Marseille, Melun, Montaigu, Nantes

2025-03-10

Recruiting

Long-Term Evaluation of TAILORED Vs Anatomical Ablation Strategy for Persistent Atrial Fibrillation

NCT06825104Atrial Fibrillation

Volta Medical

Observational

278

Bron, Clermont-Ferrand, Lomme, Marseille, Massy, Nantes, Nice, Saint-Denis

2025-03-06

Recruiting

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

NCT06742996Mantle Cell Lymphoma, B Cell Lymphoma

DrugsSonrotoclax·Zanubrutinib

BeOne Medicines

Phase 3

300

Montpellier, Nantes, PierreBenite, Tours

2025-03-05

Recruiting

Evaluation of the Concordance Between Measures Obtained by a Medical Device for Emotional Monitoring (EMOCARE) and the Patient Health Questionnaire (PHQ-9) Score in Patients With Mild to Severe Depressive Episode

NCT06601140Major Depressive Disorder (MDD)

Emobot

Not applicable

104

Agen, Caen, Laxou, Maxéville, Nantes, Paris, Reims, Rennes

2025-03-05

Recruiting

Eight-Treg Study:Trial of Adoptive Immunotherapy With Autologous ex Vivo Expanded Regulatory CD8+ T Cells in Living Donor Kidney Transplant Recipients

NCT06777719Kidney Transplantation

Nantes University Hospital

Phase 1

Nantes

2025-03-03

Not yet open

Arginin-stimulated Copeptin in Polyuria-polydipsia Syndrome in Children

NCT06604975Primary Polydipsia, Central Diabetes Insipidus, Nephrogenic Diabetes Insipidus

Assistance Publique Hopitaux De Marseille

Not applicable

155

Angers, Bordeaux, Lille, Lyon, Marseille, Montpellier, Nantes, Nice

2025-03

Recruiting

KONO-S Anastomosis Compared to Conventional Ileocolonic Anastomosis to Reduce Recurrence in Crohn's Disease

NCT05974358Crohn Disease

Centre Hospitalier Universitaire de Besancon

Not applicable

226

Besançon, Bordeaux, Grenoble, Lille, Lyon, Marseille, Nancy, Nantes

2025-03

Not yet open

Optimization of Morphinomimetic Administration Intraoperatively: Evaluation of the Impact of the NOL Index on the Occurrence of Postoperative Adverse Events Related to Morphinomimetics

NCT06861634Anesthesia, Intensive Care Medicine

University Hospital, Tours

Not applicable

332

Angers, Blois, Brest, Nantes, Tours

2025-03

Recruiting

A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer

NCT06764316Hepatocellular Carcinoma

Bayer

Phase 1

148

Montpellier, Bron, Nantes, Villejuif

2025-02-28

Recruiting

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

NCT06855498Hidradenitis Suppurativa (HS)

DrugPovorcitinib

Incyte Corporation

Phase 3

600

Antony, Bordeaux, Brest, Créteil, Lyon, Marseille, Nantes, Nice

2025-02-28

Recruiting

Characterization and Support of Neurodevelopmental Disorders Associated With Congenital Cardiac malfoRmations - Neonatal

NCT06690151Heart Disease Congenital, Neurodevelopmental Disorder

Nantes University Hospital

Observational

450

Nantes, Bordeaux, Clamart, Le Plessis-Robinson, Marseille, Paris, Toulouse, Tours

2025-02-28

Recruiting

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

NCT06767514Non-Small Cell Lung Cancer

DrugsIvonescimab·Pembrolizumab

Summit Therapeutics

Phase 3

780

Nantes, Avignon, Brest, Créteil, Lille, Lyon, Marseille, Paris

2025-02-27

Recruiting

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

NCT06731478Gastric Cancer, Gastroesophageal Junction Cancer

DrugsTrastuzumab deruxtecan·Trastuzumab·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

726

Avignon, Brest, Dijon, Grenoble, Lille, Lyon, Montpellier, Nantes

2025-02-27

Recruiting

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine

NCT06464146Limb Injury

DrugsNaCl·Fentanyl·Ketamine·Morphine

Assistance Publique - Hôpitaux de Paris

Phase 3

300

Boulogne-Billancourt, Lille, Marseille, Nantes, Paris

2025-02-26

Recruiting

Phase II Study of Glofitamab With Venetoclax +/- Zanubrutinib in High-risk Mantle-cell Lymphoma

NCT06558604Lymphoma, Mantle-Cell

DrugsGlofitamab·Zanubrutinib·Obinutuzumab·Venetoclax

The Lymphoma Academic Research Organisation

Phase 2

100

Créteil, Dijon, Lille, Marseille, Montpellier, Nantes, Pierre-Bénite, Reims

2025-02-21

Recruiting

Open-label Study of Asciminib for CML-CP or CML-AP Patients With T315I Mutation Who Are Resistant, Intolerant or Ineligible to Ponatinib.

NCT06514534Chronic Myeloid Leukemia (CML)

Novartis Pharmaceuticals

Phase 2

Bordeaux, Lille, Lyon, Nantes, Paris, Vandœuvre-lès-Nancy

2025-02-18

Recruiting

DOVIPA, a Study Evaluating Efficacy and Safety of DOstarlimab and VItamin D3 With mFOLFIRINOX in PAncreatic Cancer

NCT06757244Pancreas Neoplasms

DrugsLV5FU2·Cholecalciferol·Dostarlimab

Hopital Foch

Phase 2

Marseille, Nantes, Paris, Suresnes

2025-02-18

Recruiting

A Study to Assess How Vaborem® is Taking up in the Body and Tolerated in Paediatric Patients With Gram Negative Infections, Including But Not Restricted to Complicated Urinary Tract Infections

NCT06828848Gram Negative Infections

DrugMeropenem

Menarini Group

Phase 2

Nantes, Nice, Paris, Tours

2025-02-18

Recruiting

Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children

NCT06754709Cardiac Surgery, Extracorporeal Circulation; Complications, Metabolism, Low Cardiac Output

Nantes University Hospital

Observational

300

Nantes

2025-02-13

Not yet open

Ventilation of the Extremely Premature Infants Optimized by Dead Space Washout

NCT06334523Extremely Low Birthweight Infant, Continuous Tracheal Gas Insufflation, Medical Device, Lung Protection

Centre Hospitalier Intercommunal Creteil

Not applicable

144

Créteil, Nantes, Paris

2025-02-13

Recruiting

Prospective Multicenter Study of the Relationship Between Virological Effectiveness and Compliance in HIV-1-infected Patients Treated With Bictegravir

NCT06902142HIV Antiretroviral Therapy (ART) Adherence

Association pour la promotion de la recherche en maladies infectieuses et tropicales dans le Loiret

Observational

120

Caen, La Roche-sur-Yon, Lyon, Nantes, Niort, Orléans, Paris, Poitiers

2025-02-11

Recruiting

A Study of TAK-360 in Adults With Idiopathic Hypersomnia

NCT06812078Idiopathic Hypersomnia

DrugTAK-360

Takeda

Phase 2

Montpellier, Nantes, Paris

2025-02-07

Recruiting

Escalation of Doses of Daratumumab in Combination With Chemotherapy (Idarubicin and Cytarabine or CPX-351) in Patients of 60 Years Old or More With Adverse Risk Acute Myeloblastic Leukemia (AML) (DARALAM)

NCT05749276Adult Patients With Adverse Risk Acute Myeloblastic Leukemia

DrugDarzalex

Nantes University Hospital

Phase 1

Nantes

2025-02-06

Active, closed

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

NCT06834360Chronic Rhinosinusitis With Nasal Polyps

DrugsItepekimab·Mometasone furoate

Sanofi

Phase 3

216

Bordeaux, Marseille, Nantes, Poitiers, Pontoise, Toulouse

2025-02-06

Recruiting

Evaluation of CO Intoxication Rate, by CAPillary HbCO

NCT06641752Carbon Monoxide Intoxication

Nantes University Hospital

Observational

120

Angers, Nantes

2025-02-05

Recruiting

Inflammatory Bowel Disease Cohort in Nantes

NCT06256393Inflammatory Bowel Diseases

Nantes University Hospital

Observational

360

Nantes

2025-02-04

Recruiting

Early and Objective Assessment of Neurological Prognosis in Cardiac Arrest Patients

NCT06387225Cardiac Arrest, Neurologic Symptoms, Intensive Care Neurological Disorder

Nantes University Hospital

Observational

608

La Roche-sur-Yon, Nantes, Paris, Saint-Nazaire

2025-02-02

Recruiting

Assessment of the Impact of Intestinal Gas Emission Quality on the Postoperative Course After Abdominal Surgery

NCT06675097Postoperative Complication, Recovery, Physiological

University Hospital, Angers

Observational

200

Nantes, Angers

2025-01-31

Recruiting

Evaluation of Blood Protein O-GlcNAcylation Levels in Children

NCT06754696Sepsis, Septic Shock, Development and Health, Metabolism Changes

Nantes University Hospital

Observational

240

Nantes

2025-01-30

Recruiting

Assessment of the Prevalence of Steatotic Liver Disease Associated With Metabolic Dysfunction in Patients With Heterozygous Familial Hypercholesterolemia

NCT06634160Heterozygous Familial Hypercholesterolemia

Nantes University Hospital

Observational

200

Angers, Nantes, Rennes

2025-01-30

Recruiting

DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infection

NCT06203132HIV-1-infection

DrugsDoravirine·Tenofovir DF·Dolutegravir·Emtricitabine

ANRS, Emerging Infectious Diseases

Phase 3

610

Bordeaux, Montpellier, Nantes, Paris

2025-01-27

Recruiting

Impact of Pain From Injectables Antiretroviral Treatments in HIV-1 Patients Based on the Injection Site (Ventrogluteal or Dorsogluteal) and the Use or Non-use of Virtual Reality Headset

NCT06834113HIV I Infection, Injection Pain

Centre Hospitalier Régional d'Orléans

Not applicable

120

Orléans, La Roche-sur-Yon, Le Coudray, Nantes, Poitiers

2025-01-24

Recruiting

Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).

NCT06641414Higher-risk Myelodysplastic Syndrome

DrugsLisaftoclax·Azacitidine

Ascentage Pharma Group Inc.

Phase 3

490

Angers, Le Mans, Limoges, Nantes, Nice, Orléans, Paris, Pessac

2025-01-22

Recruiting

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

NCT06585774Chronic Graft-versus-host-disease

DrugsAxatilimab·Methylprednisolone·Prednisolone·Prednisone

Incyte Corporation

Phase 3

240

Amiens, Marseille, Nancy, Nantes, Nice, Paris, Pierre-Bénite, Toulouse

2025-01-21

Recruiting

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus

NCT06613360SLE, SLE (Systemic Lupus)

DrugCLN-978

Cullinan Therapeutics Inc.

Phase 1

Nantes, Saint-Priest-en-Jarez, Toulouse

2025-01-21

Not yet open

Prospective Observational Study Evaluating the Safety and Efficacy of Immunomodulatory Therapies in Refractory Inflammatory and Autoimmune Diseases

NCT06757426Autoimmune Diseases, Inflammatory Diseases

Groupe français d'étude des Maladies Inflammatoires de loeil

Observational

Aix-en-Provence, Blois, Caen, Le Mans, Marseille, Melun, Montfermeil, Nantes

2025-01-15

Recruiting

Perioperative Oral Vitamin D3 Supplementation on Implant Osseointegration

NCT06776640Implant Site Reaction

Nantes University Hospital

Observational

Nantes

2025-01-15

Recruiting

Impact of a Snoezelen Element on Anxiety in Patients During Oral Care: A Real-Life Study at Nantes University Hospital

NCT06776653Odontologic Disorders

Nantes University Hospital

Observational

100

Nantes

2025-01-15

Recruiting

Bronchiolitis Clearance Airways With Seaserum

NCT06177197Bronchiolitis Acute

University Hospital, Brest

Not applicable

458

Brest, Le Mans, Lille, Marseille, Morlaix, Nantes, Rennes, Tours

2025-01-10

Recruiting

Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia

NCT06602934Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease

Nantes University Hospital

Not applicable

300

Angers, Nantes, Rennes, Rouen, Toulouse

2025-01-02

Recruiting

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

NCT06227910Crohn's Disease

DrugsVedolizumab·Upadacitinib

Takeda

Phase 3

396

Amiens, Lille, Marseille, Nantes, Pessac, Saint-Etienne, Toulouse, Vandœuvre-lès-Nancy

2025-01-02

By invitation

A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring

NCT06788509Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes

DrugsJNJ-75348780·JNJ-87801493·JNJ-80948543·Ibrutinib

Janssen Research & Development, LLC

Phase 1

120

Lille, Nantes, Villejuif

2024-12-30

Recruiting

Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVD

NCT03593317Arrhythmogenic Right Ventricular Dysplasia

DrugSpironolactone

Hospices Civils de Lyon

Phase 2

120

Amiens, Bron, Clermont-Ferrand, Dijon, Grenoble, Marseille, Montpellier, Nantes

2024-12-20

Recruiting

Act on Quality of Life in Patients With aortIc Stenosis

NCT06477042Severe Aortic Stenosis

Hospices Civils de Lyon

Observational

240

Clermont-Ferrand, Lille, Lyon, Nantes

2024-12-19

Recruiting

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

NCT06736574Heart Failure, Heart Failure With Reduced Ejection Fraction

Cytokinetics

Phase 3

1,800

Toulouse, Valenciennes, Rennes, La Tronche, Montpellier, Nantes, Bron, Toulon

2024-12-19

Recruiting

CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.

NCT06269679Infective Endocarditis

Nantes University Hospital

Not applicable

170

Bordeaux, Clermont-Ferrand, Grenoble, Lyon, Marseille, Nancy, Nantes, Paris

2024-12-18

Recruiting

The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration

NCT06490822Frontotemporal Lobar Degeneration

Nantes University Hospital

Not applicable

Nantes

2024-12-17

Recruiting

A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

NCT06679101Multiple Myeloma, Newly Diagnosed Multiple Myeloma

DrugsBelantamab mafodotin·Daratumumab·Lenalidomide·Dexamethasone

GlaxoSmithKline

Phase 3

520

Bobigny, Nantes, Villejuif

2024-12-16

Recruiting

Cohorte COSCINUS - Biocollection

NCT06734000Spinal Cord Injury

Nantes University Hospital

Observational

105

Nantes

2024-12-13

Recruiting

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

NCT05421858Candidemia, Candidiasis, Invasive

DrugsCaspofungin·Fosmanogepix·Fluconazole

Basilea Pharmaceutica

Phase 3

450

Amiens, Argenteuil, Marseille, Nantes, Rennes, Tours

2024-12-11

Recruiting

Tacrolimus Minimization in Kidney Transplant Recipients Selected According to the AGORA Algorithm for Their Low Immunological Risk and Medium-term Graft Failure

NCT06235892Organ Grafts

DrugTacrolimus

Nantes University Hospital

Phase 3

300

Nantes

2024-12-10

Recruiting

Patient Safety Incidents in Coordinated Primary Care Teams: a Multi-method Study

NCT06230341Adverse Event

Nantes University Hospital

Not applicable

Nantes

2024-12-10

Recruiting

Prospective, Longitudinal Biocollection in Thoracic Oncology, Including Newly Diagnosed Lung Cancer Patients

NCT06481813Lung Cancer, Carcinoma, Non-Small-Cell Lung, Small Cell Lung Carcinoma, Metastatic Lung Cancer

Nantes University Hospital

Not applicable

730

Angers, Nantes, Rennes, Tours

2024-12-10

Recruiting

Evaluation of the Clinical and Cost-effectiveness of an Automated Mobile Hybrid Room in Vascular Surgery Compared with Current Practice

NCT06590532Endovascular

Nantes University Hospital

Not applicable

350

Besançon, Brest, Créteil, Grenoble, Nantes, Nice, Reims

2024-12-10

Recruiting

Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia

NCT06597019Familial Hypercholesterolemia - Heterozygous

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

Marseille, Nantes, Paris

2024-12-09

Recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

NCT06465953Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes (MDS)

DrugsIvosidenib·Azacitidine

Institut de Recherches Internationales Servier

Phase 3

Nantes, Nice, Paris, Pessac, Toulouse, Vandœuvre-lès-Nancy

2024-12-03

Active, closed

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

NCT06706817Chronic Rhinosinusitis With Nasal Polyps

AstraZeneca

Phase 3

181

Le Kremlin-Bicêtre, Marseille, Nantes, Pierre-Bénite, Poitiers, Toulouse

2024-12-03

Recruiting

Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive Keratoconus

NCT06450470Progressive Keratoconus

TBF Genie Tissulaire

Phase 3

116

Brest, Lyon, Marseille, Montpellier, Nantes, Paris, Saint-Priest-en-Jarez, Strasbourg

2024-11-25

Recruiting

Prospective and Comparative Evaluation of a Medical Device Composed of a Perineal Probe Connected to a Mobile Application in the Management of Stress Urinary Incontinence.

NCT06285292Urinary Incontinence

Nantes University Hospital

Not applicable

138

Nantes

2024-11-25

Recruiting

Brain Heart InterActioNs in Cardiac Arrest. Ancillary Study of the HEAVENwARd Trial

NCT06327334Cardiac Arrest

CMC Ambroise Paré

Observational

200

Brest, Nantes, Marseille, Neuilly-sur-Seine, Paris

2024-11-25

Recruiting

Tight Control for Rotator Cuff Tendinopathy

NCT06517680Rotator Cuff Tendinopathy

Nantes University Hospital

Not applicable

156

Angers, Brest, Chambray-lès-Tours, Cholet, La Roche-sur-Yon, Le Mans, Nantes, Rennes

2024-11-25

Active, closed

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

NCT06578247Leukemia

DrugQuizartinib

Daiichi Sankyo

Phase 3

700

Angers, Caen, La Tronche, Le Chesnay, Lille, Lyon, Marseille, Nantes

2024-11-19

Active, closed

A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)

NCT06422884Idiopathic Pulmonary Fibrosis, Progressive Fibrosing Interstitial Lung Disease

DrugTaladegib

Endeavor Biomedicines, Inc.

Phase 2

213

Angers, Bordeaux, Caen, Dijon, Montpellier, Nantes, Paris, Rennes

2024-11-15

Recruiting

Study of Posaconazole Prophylaxis in Patients Receiving Hematopoietic Stem Cell Allograft (Allo-HSC) at High Risk of Invasive Fungal Infection (IFI)

NCT06541067Hematologic Malignancy

DrugPosaconazole

Nantes University Hospital

Phase 2

Nantes

2024-11-08

Recruiting

Impact of the Choice of Gastric Tube Placement Sites on the Incidence of Ventilator Associated Pneumonia

NCT05915663Intubated Patient Requiring a Gastric Tube

Centre Hospitalier le Mans

Not applicable

2,400

Angers, Cholet, Grenoble, La Roche-sur-Yon, Le Mans, Marseille, Nantes, Orléans

2024-11-07

Recruiting

A Study to Investigate the Safety and Efficacy of SAR446523 Injected Subcutaneously in Adult Participants With Relapsed/Refractory Myeloma

NCT06630806Plasma Cell Myeloma Refractory

Sanofi

Phase 1

Lille, Nantes

2024-10-30

Recruiting

Heart Rate Variability in Early Prediction of a Noxic Brain Injury After Cardiac Arrest

NCT06044922Cardiac Arrest

CMC Ambroise Paré

Observational

200

Brest, Nantes, Marseille, Neuilly-sur-Seine, Paris

2024-10-23

Active, closed

Study Assessing RLT Using [177Lu]Lu-PentixaTher for Relapsed/Refractory CXCR4+ Acute Leukemia.

NCT06356922Acute Leukemia

Nantes University Hospital

Phase 1/2

Bordeaux, Nantes, Angers, Clermont-Ferrand

2024-10-22

Active, closed

Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinomas

NCT06557889Squamous Cell Carcinoma of Head and Neck

DrugsCisplatin/Carboplatin·Adrucil·Pembrolizumab

Institut Claudius Regaud

Phase 2

Amiens, Avignon, Bordeaux, Clermont-Ferrand, Limoges, Marseille, Nantes, Nice

2024-10-21

Recruiting

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

NCT06662786Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Irinotecan

Janssen Research & Development, LLC

Phase 3

1,000

Avignon, Lille, Lyon, Montpellier, Nantes, Paris, Pessac, Poitiers

2024-10-18

Recruiting

Advanced Practice Nurses for Fall Incidence PrevenTion in Very Old Robust Adults

NCT06617806Fall Prevention, Autonomy of Older People, Frail Elderly, Advanced Practice Nursing

Nantes University Hospital

Not applicable

386

Nantes

2024-10-15

Active, closed

Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health

NCT06866210Social Determinant of Health, Intracranial Aneurysms, Subarachnoid Hemorrhage, Treatment Outcomes

Nantes University Hospital

Observational

1,800

Nantes

2024-10-15

Active, closed

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)

NCT06516952Prurigo Nodularis

DrugPovorcitinib

Incyte Corporation

Phase 3

349

Antony, Brest, Martigues, Mulhouse, Nantes, Paris, Romans-sur-Isère, Toulouse

2024-10-10

Active, closed

A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

NCT06625060Episodic Migraine, Chronic Migraine

DrugCorabotase

Ipsen

Phase 2

670

Amiens, Clermont-Ferrand, Nantes, Nîmes, Paris

2024-10-10

Recruiting

Efficacy of INM004 in Children With STEC-HUS

NCT06389474Hemolytic-Uremic Syndrome

Inmunova S.A.

Phase 3

220

Bordeaux, Lyon, Montpellier, Nantes, Paris, Rouen

2024-10-05

Active, closed

BIO|MASTER.CSP Study

NCT06620237Cardiac Pacing, Artificial, Cardiac Pacemaker, Artificial, Cardiac Resynchronization Therapy Devices, Bradycardia

Biotronik SE & Co. KG

Not applicable

152

Marseille, Metz, Nantes, Pessac

2024-10-04

Active, closed

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT06417814Metastatic Non-small Cell Lung Cancer

DrugsTagrisso·Dato-DXd·Osimertinib·Pemetrexed

AstraZeneca

Phase 3

768

Bordeaux, Caen, Lille, Montpellier, Nantes, Paris, Pessac, Toulon Armees

2024-10-04

Recruiting

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

NCT05947955Acute Respiratory Distress Syndrome, Infections

BioAegis Therapeutics Inc.

Phase 2

600

La Roche-sur-Yon, Le Kremlin-Bicêtre, Melun, Nantes, Oullins-Pierre-Bénite, Paris, Strasbourg

2024-10-03

Recruiting

Echocardiography in Nursing Home

NCT06445231Heart Diseases, Heart Failure, Heart Valve Diseases

Nantes University Hospital

Not applicable

1,050

Nantes

2024-10-02

Recruiting

A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer

NCT06545955Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

DrugsNadofaragene Firadenovec·Docetaxel·Gemcitabine·Pembrolizumab

Ferring Pharmaceuticals

Phase 3

250

Clermont-Ferrand, Lyon, Toulouse, Nantes, Bordeaux, Nîmes, Paris

2024-10-01

Recruiting

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

NCT06510374Intermediate Risk Non-Muscle Invasive Bladder Cancer

DrugNadofaragene Firadenovec

Ferring Pharmaceuticals

Phase 3

454

Clermont-Ferrand, Toulouse, Nantes, Bordeaux, Rouen, Nîmes, Lyon, Paris

2024-10-01

Recruiting

Dexamethasone and Pregnancy: Maternal Effects

NCT06259994Dexamethasone During Pregnancy

Assistance Publique - Hôpitaux de Paris

Observational

Bordeaux, Bron, Grenoble, Le Kremlin-Bicêtre, Lille, Nantes, Paris, Toulouse

2024-09-30

Recruiting

Type 2 DIAbeTes With NAFLD: innOvative Biomarkers of Disease progressioN and clInical outComes

NCT06567990Metabolic Dysfunction-Associated Liver Disease

Hospices Civils de Lyon

Not applicable

500

Dijon, Lyon, Nantes, Pierre-Bénite

2024-09-25

Recruiting

Biological, Prospective Study Evaluating the Dosage of Plasma Cytokines Including the FLT3 Ligand and IL6 of Patients Treated With Non-intensive Chemotherapy

NCT06439199Acute Myeloid Leukemia, Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia

Nantes University Hospital

Observational

Nantes

2024-09-23

Recruiting

Hyaluronic Acid in Shoulder Tendinopathy

NCT06376981Shoulder Tendinitis

DrugHyaluronic Acid

Centre Hospitalier Departemental Vendee

Phase 3

132

La Roche-sur-Yon, Nantes

2024-09-19

Active, closed

A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma

NCT06190951Melanoma

DrugsFianlimab·Cemiplimab

Regeneron Pharmaceuticals

Phase 2

151

Pierre-Bénite, Dijon, Tours, Bordeaux, La Tronche, Poitiers, Caen, Nantes

2024-09-18

Active, closed

Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus)

NCT06497504Hepatitis B

DrugBepirovirsen

GlaxoSmithKline

Phase 2

153

Marseille, Melun, Montpellier, Nantes, Paris

2024-09-17

Recruiting

Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis

NCT06368804Bronchiectasis

Centre Hospitalier Intercommunal Creteil

Phase 2

196

Amiens, Bordeaux, Brest, Cergy-Pontoise, Créteil, Lyon, Marseille, Nantes

2024-09-15

Active, closed

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

NCT06581198Lupus Erythematosus, Systemic, Lupus Nephritis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 2

179

Bordeaux, Clermont-Ferrand, Marseille, Montpellier, Nantes, Paris, Strasbourg, Toulouse

2024-09-04

Not yet open

Effects of an Eccentric Muscle Strengthening Protocol on Force Moment, Muscle Activation and Plantar Flexor Structure of Patients With Central Nervous System Injuries.

NCT06099340Spinal Cord Injured, Post-stroke

Nantes University Hospital

Not applicable

Nantes

2024-09

Active, closed

Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)

NCT06564142Immunoglobulin A Nephropathy

DrugPovetacicept

Alpine Immune Sciences Inc, A Subsidiary of Vertex

Phase 3

605

Bordeaux, Créteil, Le Puy-en-Velay, Marseille, Nantes, Paris, Saint-Priest-en-Jarez, Valenciennes

2024-08-30

Recruiting

Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome

NCT06244433Sudden Infant Death, Sudden Unexplained Infant Death

Nantes University Hospital

Observational

650

Nantes, Amiens, Angers, Besançon, Bondy, Brest, Caen, Clamart

2024-08-27

Recruiting

Observational Study of Venus P-Valve

NCT05835349Right Ventricular Outflow Tract Dysfunction

Venus MedTech (HangZhou) Inc.

Observational

200

Pessac, Nantes, Le Plessis-Robinson, Paris

2024-08-26

Active, closed

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

NCT06413498Multiple Myeloma

DrugsAnitocabtagene Autoleucel·Carfilzomib·Pomalidomide·Bortezomib

Kite, A Gilead Company

Phase 3

452

Lille, Marseille, Montpellier, Nantes, Paris, Pierre-Bénite, Poitiers, Rennes

2024-08-23

Active, closed

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

NCT06461897Atopic Dermatitis

DrugsUpadacitinib·Dupilumab

AbbVie

Phase 3

699

Toulouse, Vandœuvre-lès-Nancy, Bordeaux, Nantes, Clermont-Ferrand, Amiens, Paris, Argenteuil

2024-08-19

Recruiting

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

NCT06395103B-cell Acute Lymphoblastic Leukemia, Diffuse Large B-cell Lymphoma, Burkitt Lymphoma, Neuroblastoma

DrugZilovertamab vedotin

Merck Sharp & Dohme LLC

Phase 1/2

Bordeaux, Lyon, Nantes, Marseille, Villejuif

2024-08-16

Recruiting

Research Project on the Risk of Discomfort, Pain, Alteration of Skin Condition in Bedpan Use by Patients and Caregivers

NCT06332495Nurse-Patient Relations

Nantes University Hospital

Observational

300

Nantes, Cholet, Laval, Le Mans, Orléans

2024-08-03

Recruiting

Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

NCT05014581Critical Illness, Respiratory Failure

DrugsNoradrenaline·Norepinephrine

University of Turin, Italy

Phase 3

420

Nantes

2024-08-01

Recruiting

Effect of Probiotics on Infantile Colic Symptoms

NCT06385054Infantile Colic

Lallemand Health Solutions

Phase 2

Bécon-les-Granits, Boulogne-sur-Mer, Caen, La Tronche, Lille, Montauban, Nantes, Paris

2024-08

Recruiting

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

NCT06216301Metastatic Non-small Cell Lung Cancer

DrugPembrolizumab

NovoCure GmbH

Phase 3

734

Créteil, Limoges, Marseille, Nantes, Paris, Pessac, Pierre-Bénite, Strasbourg

2024-07-31

Active, closed

NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastatic Neuroendocrine Prostate Cancer.

NCT06379217Metastatic Neuroendocrine Prostate Cancer

Drugs[68Ga]Ga-PSMA-11·[177Lu]Lu-DOTA-TATE·[68Ga]Ga-DOTA-TATE·Ga-NeoB

Novartis Pharmaceuticals

Phase 1

Nantes

2024-07-29

Recruiting

Drowning-related Acute Respiratory Failure

NCT06183827Drowning

Assistance Publique Hopitaux De Marseille

Not applicable

210

Bayonne, Bordeaux, La Rochelle, Les Sables-d'Olonne, Marseille, Montpellier, Nantes, Nice

2024-07-24

Recruiting

A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors

NCT06427941Metastatic Hepatocellular Carcinoma, Local Advanced Hepatocellular Carcinoma, Alpha-fetoprotein (AFP)-Producing Gastric Cancer, Extragonadal Yolk Sac Tumors

DrugsTislelizumab·Bevacizumab

BeOne Medicines

Phase 1/2

630

Clichy, Nantes, Villejuif

2024-07-23

Active, closed

A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease

NCT06544616Alzheimer Disease

Janssen Pharmaceutica N.V., Belgium

Phase 2

Lille, Nantes, Paris, Toulouse, Tours

2024-07-22

Recruiting

Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation

NCT06252870Graft Versus Host Disease, Hematologic Malignancy

DrugsClofarabine·Thiotepa·Busulfan·Methotrexate

Nantes University Hospital

Phase 2

Angers, Brest, Nantes

2024-07-18

Recruiting

Multi-modal Characterisation of Hepatocellular Carcinoma (HCC) Treated With Targeted Radionuclide Therapy (TRT): Prospective Interventional Multicentre National Cohort

NCT06334965Hepatocellular Carcinoma, Radioembolization

Assistance Publique - Hôpitaux de Paris

Not applicable

180

Clichy, Nantes, Paris

2024-07-18

Active, closed

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

NCT06456346Essential Thrombocythemia

DrugsBomedemstat·Hydroxyurea

Merck Sharp & Dohme LLC

Phase 3

300

Nice, Pessac, Marseille, Toulouse, Limoges, Tours, Nantes, Pierre-Bénite

2024-07-16

Active, closed

A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery

NCT06161441Resectable Non-small Cell Lung Cancer

DrugsFianlimab·Cemiplimab·Paraplatin·Taxol

Regeneron Pharmaceuticals

Phase 2

195

Nancy, Saint-Herblain, Bordeaux, Limoges, Boulogne-Billancourt, Dijon, Nantes, Vantoux

2024-07-16

Recruiting

COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial

NCT06425614On-pump Cardiac Surgery, High Risk for Bleeding, Autotransfusion

University Hospital, Bordeaux

Not applicable

570

Bordeaux, Bron, Montpellier, Nantes, Paris, Rennes, Strasbourg, Toulouse

2024-07-15

Recruiting

Prospective Study of the Methods and Outcomes of CHYME REinstillation After Small Bowel Surgery

NCT06751628Enterostomy

Nantes University Hospital

Observational

100

Nantes

2024-07-14

Active, closed

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

NCT06445023Chronic Spontaneous Urticaria

DrugBarzolvolimab

Celldex Therapeutics

Phase 3

963

Pierre-Bénite, La Tronche, Martigues, Nantes, Nice, Paris, Rouen

2024-07-11

Recruiting

Characterization and Support for Neurodevelopmental Disorders Associated With Congenital Heart Defects

NCT06442592Congenital Heart Defects, Neurodevelopmental Disorder

Nantes University Hospital

Not applicable

1,206

Brest, Rennes, Nantes, Angers, Tours

2024-07-08

Recruiting

Prediction of Undesired Obstruction in External Ventricular Drains.

NCT06466811Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain

Nantes University Hospital

Observational

640

Nantes

2024-07-04

Recruiting

Parathyroid Assessment of Symptoms French Version

NCT06450431Quality of Life in Primary Hyperparathyroidism

Nantes University Hospital

Observational

548

Nantes

2024-07-01

Recruiting

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

NCT06427304Cardiac Amyloidosis

Gérond'if

Observational

637

Paris, Nantes, Poitiers, Rouen, Montpellier, Toulouse, Amiens, Angers

2024-07-01

Active, closed

A Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus

NCT06015737Cutaneous Lupus Erythematosus

AstraZeneca

Phase 3

339

Bois-Guillaume, Dijon, Lyon, Montivilliers, Nantes, Paris, Poitiers, Toulouse

2024-06-29

Active, closed

Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)

NCT06331312Polymyalgia Rheumatica

DrugSecukinumab

Novartis Pharmaceuticals

Phase 3

162

Toulon, Brest, Cholet, Colmar, Dijon, Le Mans, Nantes, Reims

2024-06-28

Active, closed

Assessment of HGI (Hemoglobin Glycation Index) Variability Over Time in Patients Living With Diabetes Using Continuous Glucose Monitoring ( GAP OUEST )

NCT06185491Diabetes Mellitus

Nantes University Hospital

Not applicable

750

Angers, Brest, Caen, Le Mans, Nantes, Poitiers, Pontoise, Rennes

2024-06-24

Recruiting

A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients

NCT06923150Gastroenterology, LARS - Low Anterior Resection Syndrome, Rectal Cancer

Qufora A/S

Observational

Amiens, Besançon, Bordeaux, La Tronche, Marseille, Nantes, Pessac, Pierre-Bénite

2024-06-18

Recruiting

Golcadomide Post-CAR T-cell in R/R Aggressive Large B-cell Lymphoma Patients With High Risk of Relapse

NCT06271057Diffuse Large B-cell Lymphoma Refractory, Refractory Primary Mediastinal Large B-Cell Lymphoma, Refractory Transformed B-cell Non-Hodgkin Lymphoma, Refractory High Grade B-Cell Lymphoma

DrugGolcadomide

The Lymphoma Academic Research Organisation

Phase 2

Créteil, Dijon, La Tronche, Lille, Marseille, Montpellier, Nantes, Paris

2024-06-14

Active, closed

A Study Comparing Pre- and Post-Change Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT06425991Multiple Myeloma

DrugTeclistamab

Janssen Research & Development, LLC

Phase 1

108

Lille, Lyon, Nantes, Pessac

2024-06-07

Recruiting

IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

NCT06112314Advanced Melanoma

DrugsBrenetafusp·Relatlimab·Opdivo·Nivolumab

Immunocore Ltd

Phase 3

680

Marseille, Toulouse, Bobigny, Boulogne-Billancourt, Caen, Dijon, Lille, Nantes

2024-06-05

Active, closed

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

NCT06507306Solid Tumor, Adult

DrugsKQB198·Tagrisso·Amivantamab·Osimertinib

Kumquat Biosciences Inc.

Phase 1

Marseille, Saint-Herblain, Bordeaux, Toulouse, Nantes

2024-06-03

Recruiting

Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

NCT06479135Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis, Primary Myelofibrosis

DrugsNavtemadlin·Jakavi·Ruxolitinib

Kartos Therapeutics, Inc.

Phase 3

600

Paris, Amiens, Angers, Lille, Lyon, Nantes, Nice, Nîmes

2024-06-03

Active, closed

A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

NCT05963074Leukemia, Lymphocytic, Chronic, B-Cell, Small Lymphocytic Lymphoma

DrugsIbrutinib·Venclexta·Venetoclax

Janssen Research & Development, LLC

Phase 2

333

Clermont-Ferrand, Nantes, Paris, Pierre-Bénite, Reims, Strasbourg

2024-05-30

Active, closed

A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease

NCT06401044Thyroid Eye Disease

DrugAMG 732

Amgen

Phase 1/2

Nantes, Paris

2024-05-30

Active, closed

Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of STT Osteoarthritis

NCT06038331Osteoarthritis Hand

TBF Genie Tissulaire

Phase 2

Besançon, Lyon, Nantes, Strasbourg

2024-05-28

Recruiting

Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)

NCT06347315Mild Cognitive Impairment

Société des Produits Nestlé (SPN)

Not applicable

380

Bron, Montpellier, Nantes, Toulouse

2024-05-24

Recruiting

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

NCT06237452Clostridium Difficile, Clostridium Difficile Infections, Clostridium Difficile Infection Recurrence, Clostridioides Difficile Infection

Vedanta Biosciences, Inc.

Phase 3

852

Les Paris, Dijon, Paris, Bordeaux Cedex, Garches, Nantes, Lyon, Tours

2024-05-20

Recruiting

Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis

NCT06414954Myasthenia Gravis, Myasthenia Gravis, MuSK

NMD Pharma A/S

Phase 2

Bordeaux, Marseille, Nantes, Nice

2024-05-16

Recruiting

Kidney Graft Tolerance KTOL

NCT06271343Kidney Transplant Tolerance

Nantes University Hospital

Observational

Nantes

2024-05-14

Active, closed

Use of Elranatamab in Patients With High-risk Smoldering Multiple Myeloma

NCT06183489Smoldering Multiple Myeloma

DrugElranatamab

European Myeloma Network B.V.

Phase 2

La Roche-sur-Yon, Montpellier, Nantes, Poitiers, Tours

2024-05-14

Recruiting

Belatacept as a Replacement for CNIs 3 to 12 Months Post-transplantation in Patients With Early Graft Dysfunction

NCT05562869Chronic Kidney Failure

Nantes University Hospital

Phase 3

Nantes

2024-05-03

Recruiting

Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint Infections

NCT05902221Infections Joint Prosthetic

DrugsRifampicin·Moxifloxacin·Amoxicillin

Centre Hospitalier Universitaire de Nice

Phase 3

235

Annecy, Bordeaux, Boulogne, Lyon, Marseille, Montpellier, Nantes, Nice

2024-05-02

Active, closed

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

NCT06383390Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

DrugRetatrutide

Eli Lilly and Company

Phase 3

10,000

Bois-Guillaume, Bordeaux, Clermont-Ferrand, Corbeil-Essonnes, La Tronche, Le Coudray, Montpellier, Nantes

2024-04-30

Active, closed

A Study Evaluating APG777 in Atopic Dermatitis

NCT06395948Atopic Dermatitis

DrugAPG777

Apogee Therapeutics, Inc.

Phase 2

470

Rouen, Martigues, Nantes

2024-04-29

Recruiting

Study of OCT Peripapillary Angiography in Patients With Advanced Glaucoma

NCT06274593Glaucoma

Nantes University Hospital

Observational

Nantes

2024-04-27

Recruiting

Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward

NCT06229288Community-acquired Pneumonia

DrugsAmoxicillin-clavulanate·Amoxicillin

Nantes University Hospital

Phase 3

326

Saint-Nazaire, Angers, Bobigny, Brest, La Roche-sur-Yon, La Tronche, Marseille, Nantes

2024-04-25

Recruiting

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

NCT06385080Squamous Cell Carcinoma of Head and Neck

DrugsAmivantamab·Paraplatin·Taxol·Keytruda

Janssen Research & Development, LLC

Phase 1/2

287

Avignon, Lille, Nantes, Paris, Villejuif

2024-04-22

Recruiting

Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries

NCT05885529Traumatic Brain Injury

Centre Hospitalier Princesse Grace

Observational

1,500

Angers, Clermont-Ferrand, Dijon, Grenoble, Lyon, Montpellier, Nantes, Nice

2024-04-19

Active, closed

Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients

NCT06408935Crohn's Disease

DrugsTremfya·Guselkumab

Janssen-Cilag Ltd.

Phase 3

120

Amiens, Clermont-Ferrand, Lille, Marseille, Nantes, Paris

2024-04-17

Active, closed

A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.

NCT06372145Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis

DrugTeriflunomide

Sanofi

Phase 3

2,500

Besançon, Bron, Clermont-Ferrand, Gonesse, Lille, Montpellier, Nancy, Nantes

2024-04-16

Recruiting

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

NCT06312176Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

1,200

Lyon, Caen, Montpellier, Nantes, Poitiers, Paris

2024-04-14

Recruiting

Attention Deficit Hyperactivity Disorder

NCT06232226Attention Deficit Hyperactivity Disorder, Behavior Hyperactive, Behavior Disorders

Nantes University Hospital

Not applicable

Nantes, Brest, Tours

2024-04-11

Recruiting

Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation

NCT06322017Atrial Fibrillation

Nantes University Hospital

Not applicable

294

Nantes

2024-04-09

Recruiting

Survey of Adult Participants Enrolled in Decentralized Clinical Trials

NCT06751641Clinical Trial Incorporating Decentralized Elements

Nantes University Hospital

Observational

200

Nantes

2024-04-05

Recruiting

Multicenter Real-life Observational Study Switched Aflibercept or Ranibizumab to Faricimab in Patients With AMD.

NCT06271330Age-related Macular Degeneration

DrugFaricimab

Nantes University Hospital

Observational

100

Nantes

2024-04-01

Not yet open

Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)

NCT06349798Total Hip Arthroplasty

DrugsNefopam·NaCl

University Hospital, Tours

Phase 3

546

Angers, Blois, Chartres, Nantes, Orléans, Poitiers, Tours

2024-04

Active, closed

Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

NCT06291376Immunoglobulin A Nephropathy, IgAN

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Phase 3

584

Amiens, Bayonne, Brest, Chambéry, Le Kremlin-Bicêtre, Marseille, Nantes, Paris

2024-03-29

Active, closed

Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06290934Ulcerative Colitis

Gilead Sciences

Phase 2

228

La Tronche, Nantes, Pierre-Bénite

2024-03-27

Recruiting

A Clinical Study of MK-4208/TERN-701 in Participants With Chronic Myeloid Leukemia (CML) (MK-4208-003/Tern701-1012/CARDINAL)

NCT06163430Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Chronic Myeloid Leukemia, Chronic Phase, Chronic Myeloid Leukemia

DrugHS-10382

Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 1/2

330

Lyon, Bordeaux, Marseille, Nantes, Paris, Pierre-Bénite

2024-03-26

Recruiting

Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera

NCT06093672Polycythemia Vera

DrugHydroxyurea

Italfarmaco

Phase 3

220

Saint-Quentin, Nice, Troyes, Tours, Nantes, Angers, Amiens, Paris

2024-03-26

Recruiting

Bougie Versus Endotracheal Tube Alone on First-attempt Intubation Success in Prehospital Emergency Intubation (BETA Trial)

NCT06307392Acute Respiratory Failure Requiring Intubation

Nantes University Hospital

Not applicable

710

Nantes, Besançon, Bordeaux, Clermont-Ferrand, La Roche-sur-Yon, Lorient, Lyon, Nancy

2024-03-26

Recruiting

Multi-modal Characterisation of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NETs) Treated With Targeted Radionuclide Therapy (TRT): Prospective Interventional Multicentre National Cohort

NCT06256705Gastroenteropancreatic Neuroendocrine Tumor, Radiotherapy

Assistance Publique - Hôpitaux de Paris

Not applicable

Clichy, Nantes, Paris

2024-03-25

Recruiting

Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy

NCT05952167Radiculopathy, Cervical

Centre Hospitalier Departemental Vendee

Not applicable

206

La Roche-sur-Yon, La Rochelle, Le Puy-en-Velay, Limoges, Nantes, Paris, Reims, Rouen

2024-03-25

Active, closed

A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis

NCT06257875Ulcerative Colitis

DrugsLutikizumab·Humira·Adalimumab

AbbVie

Phase 2

156

Nice, Toulouse, Créteil, Nantes, St-Priest-en-Jarez

2024-03-23

Recruiting

Interest of a Hybrid Connected Watch for Cardiac Rhythm Monitoring in Post-operative Cardiac Surgery

NCT05664308Atrial Fibrillation

Nantes University Hospital

Observational

106

Nantes

2024-03-19

Recruiting

Biocollection on Peripheral Inflammation

NCT05934474Schizoaffective Disorder, Depressive Type, Bipolar Disorder I, Bipolar Disorder II

Nantes University Hospital

Observational

Nantes

2024-03-19

Recruiting

Vegetalization of the Maternal Diet During Pregnancy: Association With Pregnancy Outcomes and Newborn Health.

NCT06155344Diet During Pregnancy

Nantes University Hospital

Observational

670

Nantes

2024-03-18

Active, closed

AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2

NCT06346392Gastric Cancer, Gastroesophageal Junction Cancer

DrugsSonesitatug Vedotin·Ramucirumab·Trifluridine/Tipiracil·Apatinib

AstraZeneca

Phase 3

594

Besançon, Brest, Lille, Lyon, Nantes

2024-03-04

Recruiting

Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting

NCT06081400Desmoid Tumor

University Hospital, Strasbourg, France

Not applicable

150

Besançon, Bordeaux, Caen, Dijon, Lyon, Marseille, Nantes, Nice

2024-03-04

Recruiting

Evaluation of Possible Postoperative Complications After Nissen Sleeve Gastrectomy. French Multicenter Study

NCT06271317Obesity

Nantes University Hospital

Observational

100

Nantes

2024-03-01

Recruiting

Mpact 3D Metal Monolit Study

NCT06748885Total Hip Arthroplasty (THA)

Medacta International SA

Observational

Nantes, Paris

2024-02-28

Recruiting

DEprescribing: Perceptions of PAtients Living With Advanced Cancer

NCT06193083Deprescribing, Palliative Care, Oncology

Nantes University Hospital

Observational

325

La Roche-sur-Yon, Lyon, Nantes, Paris, Saint-Herblain, Saint-Nazaire, Tours

2024-02-28

Recruiting

Efficacy and Safety of Methotrexate Versus Placebo in Adults With Atopic Dermatitis.

NCT06239311Moderate to Severe Atopic Dermatitis

DrugMethotrexate

medac GmbH

Phase 3

277

Bordeaux, Clermont-Ferrand, Nantes, Pierre-Bénite

2024-02-27

Recruiting

A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

NCT06161025Solid Cancer

DrugsR-DXd·Topotecan·Paclitaxel

Daiichi Sankyo

Phase 2/3

860

Bordeaux, Caen, Clermont-Ferrand, Dijon, Lyon, Marseille, Montpellier, Nantes

2024-02-27

Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

NCT06172478Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer

DrugPatritumab deruxtecan

Daiichi Sankyo

Phase 2

740

Bordeaux, Dijon, Lille, Lyon, Marseille, Nantes, Toulouse, Vandœuvre-lès-Nancy

2024-02-26

Recruiting

Discovering New Insights Into Anorexia Nervosa: Influence of MicrObial DysbiosiS (DIAMOnDS)

NCT06043154Anorexia Nervosa

Nantes University Hospital

Not applicable

Nantes

2024-02-22

Recruiting

Efficacy of 7 Days Versus 14 Days of Antibiotic Therapy for Acute Pyelonephritis in Kidney Transplant Recipients, a Multicentre Randomized Non-inferiority Trial.

NCT05597540Pyelonephritis Acute, Kidney Transplant Infection

Assistance Publique - Hôpitaux de Paris

Phase 3

470

Bordeaux, Boulogne-Billancourt, Créteil, Lyon, Nantes, Paris, Toulouse

2024-02-22

Active, closed

A Study to Investigate Efficacy and Safety of TOUR006 in Participants 18 to 80 Years of Age With Thyroid Eye Disease

NCT06088979Thyroid Eye Disease

Tourmaline Bio, Inc., a Novartis Company

Phase 2

Angers, Nantes

2024-02-19

Active, closed

Measurement of the Performance and Safety of RTR+Membrane in Guided Tissue Regeneration (GTR) in Dental Surgical Procedures

NCT06467630Guided Bone Regeneration

Septodont

Observational

Nantes, Nozay, Olonne-sur-Mer, Orée d'Anjou, Orvault

2024-02-09

Recruiting

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

NCT06152575Multiple Myeloma

DrugsElotuzumab·Elranatamab·Carfilzomib·Pomalidomide

Pfizer

Phase 3

492

Pessac, Toulouse, Nantes, Pontoise, Créteil, City/Town/Village, Bayonne, La Roche-sur-Yon

2024-02-08

Active, closed

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

NCT06191744Follicular Lymphoma (FL)

DrugsEpcoritamab·Bendamustine·Obinutuzumab·Vincristine

Genmab

Phase 3

1,095

Caen, Brest, Nantes, Avignon, Pierre-Bénite, Le Mans, Libourne, Paris

2024-02-05

Active, closed

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

NCT05853575Advanced Cancer, Metastatic Cancer, Malignant Neoplasm of Lung

DrugAdagrasib

Mirati Therapeutics Inc.

Phase 2

200

Grenoble, Pessac, Saint-Herblain, Angers, Lorient, Nantes, Poitiers, Nice

2024-02-01

Active, closed

A Study About Antibody Levels and Biomarkers in the Blood in People With Late-onset Pompe Disease

NCT06150820Pompe Disease (Late-onset)

Astellas Gene Therapies

Not applicable

119

Angers, Garches, Lille, Limoges, Marseille, Nantes, Nice, Strasbourg

2024-02-01

Active, closed

A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa

NCT06212999Hidradenitis Suppurativa (HS)

DrugPovorcitinib

Incyte Corporation

Phase 3

617

Bordeaux, Brest, Dijon, Le Mans, Lyon, Marseille, Nantes, Nice

2024-01-30

Recruiting

The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis

NCT05564936Myasthenia Gravis

Ad scientiam

Not applicable

144

Garches, Grenoble, Lille, Nancy, Nantes, Paris, Strasbourg, Toulouse

2024-01-24

Active, closed

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

NCT06143891Chronic Graft Versus Host Disease

DrugsBelumosudil·Prednisolone·Prednisone

Sanofi

Phase 3

260

Marseille, Nantes, Paris, Pessac, Pierre-Bénite, Rennes, Vandœuvre-lès-Nancy

2024-01-23

Active, closed

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

NCT06208150Multiple Myeloma

DrugsElotuzumab·Talquetamab·Velcade·Teclistamab

Janssen Research & Development, LLC

Phase 3

838

Lille, Limoges, Lyon, Marseille, Nantes, Paris, Pessac, Strasbourg

2024-01-22

Recruiting

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

NCT06162221Non-Small Cell Lung Cancer, NSCLC, KRAS, NRAS, HRAS-mutated NSCLC, KRAS G12C-mutated Solid Tumors, Lung Cancer, Lung Cancer Stage IV, Advanced Solid Tumor, Cancer

DrugsElironrasib·RMC-9805·Cetuximab·Pemetrexed

Revolution Medicines, Inc.

Phase 1/2

616

Bron, Dijon, Lille, Nantes, Bordeaux, Angers, Boulogne, Caen

2024-01-18

Recruiting

Study on the Treatment of Anal Fistulas Using Alofisel Versus Fat Autologous Stem Cells

NCT05974280Crohn Disease, Anal Fistula

Nantes University Hospital

Observational

Nantes

2024-01-02

Recruiting

Evaluation of Tibial Nerve Selective Neurotomy Compared to Botulinum Toxin Injections for Spastic Foot Treatment in Post-stroke Patients According to a Goal-centered Approach

NCT05874154Post Stroke Seizure, Spastic Foot

DrugBotulinum toxin

Hospices Civils de Lyon

Not applicable

Bron, Clichy, Nantes, Saint-Genis-Laval

2024-01-02

Recruiting

AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia

NCT06137118B-cell Acute Lymphoblastic Leukemia (B-ALL)

DrugSurovatamig

AstraZeneca

Phase 1/2

255

Caen, Marseille, Nantes, Paris, Pierre-Bénite, Toulouse

2023-12-29

Recruiting

A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone Lymphoma

NCT06149286Relapsed/Refractory Follicular Lymphoma, Relapsed/Refractory Marginal Zone Lymphoma (R/R MZL)

DrugsOdronextamab·Lenalidomide·Rituximab

Regeneron Pharmaceuticals

Phase 3

580

Marseille, Rennes, Tours, Bordeaux, Pessac, Lille, Rouen, Nantes

2023-12-28

Recruiting

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

NCT06059638Hypertension, Hypertension, Systolic, Hypertension, Essential

Orchestra BioMed, Inc

Not applicable

316

Grenoble, Lyon, Nantes, Paris, Tours

2023-12-27

Recruiting

Global Trial in APG2575 for Patients With CLL/SLL

NCT06104566CLL/SLL

DrugLisaftoclax

Ascentage Pharma Group Inc.

Phase 3

400

Clermont-Ferrand, Le Mans, Lyon, Nantes, Nîmes, Orléans, Poitiers, Pontoise

2023-12-20

Active, closed

Proof of Concept Study on Pitolisant Effect on Autism Spectrum Disorders in Children and Adolescents

NCT05953389Autism Spectrum Disorder

DrugPitolisant

Bioprojet

Phase 2

Bordeaux, Nantes, Sotteville-lès-Rouen

2023-12-20

Recruiting

Tucatinib in Combination With Oral Etoposide andTrastuzumab in Patients With Metastatic HER2+ Breast Cancer

NCT05955170HER2-positive Breast Cancer

Institut Curie

Phase 2

Clermont-Ferrand, Amiens, Avignon, Caen, Dijon, Lille, Montpellier, Nantes

2023-12-19

Recruiting

A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials

NCT06285318Relapsed/Refractory Multiple Myeloma (RRMM)

Janssen-Cilag Ltd.

Observational

900

Lille, Marseille, Nantes, Paris, Toulouse, Vandœuvre-lès-Nancy

2023-12-18

Recruiting

Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

NCT06059313Behavioral Variant of Frontotemporal Disorder (bvFTD), Phenocopy Frontotemporal Dementia (phFTD), Frontal Variant of Alzheimer Disease, Bipolar Disorder

Nantes University Hospital

Observational

120

Nantes

2023-12-14

Recruiting

A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

NCT06091865Diffuse Large B-cell Lymphoma (DLBCL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

904

Quimper, Rennes, Tours, Bordeaux, Pessac, Poitiers, Lille, Nantes

2023-12-13

Recruiting

Long Term Follow-up of the TREOCAPA Study (TREOCAPA-LT)

NCT06064825Patency of the Ductus Arteriosus Acetaminophen Extreme Prematurity

Institut National de la Santé Et de la Recherche Médicale, France

Observational

500

Angers, Bron, Montpellier, Nantes, Paris, Strasbourg, Tours

2023-12-12

Recruiting

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

NCT06091254Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Bendamustine

Regeneron Pharmaceuticals

Phase 3

822

Rennes, Tours, Nantes, Marseille, Poitiers, Angers, Paris, Strasbourg

2023-12-12

Active, closed

A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines

NCT05976243Chronic Inducible Urticaria

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

362

Grenoble, Montpellier, Nantes, Paris, Pierre-Bénite, Rouen, Toulouse

2023-12-07

Active, closed

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06029972Ulcerative Colitis

Gilead Sciences

Phase 2

176

Grenoble, Little Cedex, Montpellier, Nantes, Neuilly-sur-Seine, Saint-Etienne, Toulouse, Vandœuvre-lès-Nancy

2023-12-05

Recruiting

AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

NCT06106945Multiple Myeloma

DrugsElranatamab·Pomalidomide·Dexamethasone

AstraZeneca

Phase 1/2

226

Lille, Nantes

2023-12-05

Active, closed

A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)

NCT06127043Ulcerative Colitis

DrugRosnilimab

AnaptysBio, Inc.

Phase 2

132

Nantes, Tours

2023-12-04

Recruiting

Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study

NCT05935358Severe Hemophilia A

DrugNuwiq

Octapharma

Phase 4

Nantes, Tours

2023-11-28

Recruiting

Validation of Biomarkers Performance to Reduce Antibiotics overUse in newBorns With Suspected Clinical Signs of InfectionS

NCT06058819Neonatal Late Onset Sepsis

Hospices Civils de Lyon

Observational

285

Bron, Grenoble, Nantes

2023-11-22

Active, closed

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

NCT06016738Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Exemestane·Anastrozole·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

510

Bourg-en-Bresse, Besançon, Nantes, Compiègne, Clermont-Ferrand, Le Mans, Villejuif, Caen

2023-11-16

Recruiting

Impact of Bacterial Expression and Immune Response in the Severity of Pertussis

NCT05897879Bordetella Pertussis, Whooping Cough

DrugsNasopharyngeal swab·Blood samples

Institut Pasteur

Not applicable

210

Bordeaux, Colombes, Créteil, Lille, Lyon, Marseille, Nantes, Paris

2023-11-16

Recruiting

Contribution of the Indoor Environment Medical Advisor in the Management of Fibrosing Hypersensitivity Pneumonitis

NCT05988437Hypersensitivity Pneumonitis

Nantes University Hospital

Observational

100

Nantes, Ancenis, Angers, Châteaubriant, La Roche-sur-Yon, Les Sables-d'Olonne, Saint-Nazaire

2023-11-16

Recruiting

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

NCT06128551Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer, Pancreatic Ductal Adenocarcinoma

DrugsElironrasib·Cetuximab

Revolution Medicines, Inc.

Phase 1/2

534

Angers, Bordeaux, Bron, Lille, Lyon, Montpellier, Nantes, Strasbourg

2023-11-14

Recruiting

HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies

NCT05658640Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory

DrugsTrametinib·Cytarabine·Dexamethasone·Cyclophosphamide

Princess Maxima Center for Pediatric Oncology

Phase 1/2

Bordeaux, Lille, Lyon, Marseille, Nantes, Paris

2023-11-14

Recruiting

Adapted Physical Activity in the Treatment of Anorexia:

NCT05477537Anorexia Nervosa

Fondation Santé des Étudiants de France

Not applicable

220

Lille, Lyon, Montpellier, Nantes, Paris, Saint-Etienne

2023-11-14

Active, closed

A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma

NCT06097364Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

733

Cannes, Tours, Nîmes, Mont-de-Marsan, Nantes, Cergy-Pontoise, Grenoble, Le Puy-en-Velay

2023-11-14

Active, closed

Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease

NCT06075706Steroid-refractory Acute Graft-versus-host Disease

DrugMC0518

medac GmbH

Phase 2

Bordeaux, La Tronche, Lille, Lyon, Marseille, Montpellier, Nantes, Paris

2023-11-13

Recruiting

A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral Activity of Maribavir for the Treatment of Cytomegalovirus (CMV) Infection in Children and Adolescents Who Have Received a Hematopoietic Stem Cell Transplant (HSCT) or a Solid Organ Transplant (SOT)

NCT05319353Cytomegalovirus (CMV)

DrugMaribavir

Takeda

Phase 3

Rennes, La Tronche, Nantes, Paris

2023-11-13

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a French investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 26 October 2026. https://priyalifescience.com/clinical-trials-france/city/nantes

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in France and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,697 studies in total at the last sync on 26 Oct 2026, 03:20 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 906 of those studies with a site in Nantes.

How many clinical trials are recruiting in Nantes?

523 of the 906 studies on this page are recruiting new participants as of the 26 Oct 2026, 03:20 UTC sync. A further 77 have not yet opened recruitment, 294 are active but closed to new participants, and 12 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Nantes), 906 studies
Phase	Studies	Recruiting	Share
Phase 3	285	128	31.5%
Not applicable	192	131	21.2%
Observational	181	128	20%
Phase 2	126	59	13.9%
Phase 1/2	57	37	6.3%
Phase 1	34	19	3.8%
Phase 2/3	17	11	1.9%
Phase 4	14	10	1.5%

Most active sponsors

Lead sponsors with the most studies (Nantes)
Lead sponsor	Studies	Recruiting
Nantes University Hospital	176	135
Janssen Research & Development, LLC	35	14
AstraZeneca	27	10
Novartis Pharmaceuticals	25	12
Sanofi	17	7
AbbVie	16	5
Assistance Publique - Hôpitaux de Paris	16	13
University Hospital, Brest	16	11
Hoffmann-La Roche	15	4
Bristol-Myers Squibb	13	4

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.