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Clinical Trials in France / NCT06625762
Recruiting Not applicable

Nantes Bariatric Surgery Cohort

NCT06625762 · tracked via the Priya Life Science France tracker
Sponsor
Nantes University Hospital
Phase
Not applicable
Started
2026-03-23
Last updated
2026-04-03

Condition(s) studied

Obesity

Investigational drug(s) / intervention(s)

Nantes bariatric surgery cohort

Nantes bariatric surgery cohort: The participants will be individuals living with obesity undergoing bariatric surgery

Study summary

While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese individuals. The NBC study aims to investigate :

1. Whether bariatric surgery is associated with changes in biological age
2. If bariatric surgery alters adipocyte dysfunction, the microbiota and biological rhythms
3. Whether changes in adipocyte dysfunction, microbiota and biological rhythms are linked to changes in biological age.

To achieve this, establishing a biocollection before, during and after bariatric surgery will be crucial in addressing these questions

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria : Individuals selected for bariatric surgery (starting the BC pathway within the Nantes University Hospital bariatric unit). Inclusion criteria are those of the Bariatric Surgery program. * male or female, adult over 18 years of age * BMI ≥ 35 kg/m2 with complication(s) or ≥ 40 kg/m2 with or without complication (the list of eligible complications is referenced in HAS 2024 recommendations). In the event of a change in access to bariatric surgery, this threshold could be revised without any substantial change to the protocol. * having consented to their participation in the cohort * participant affiliated to or benefiting from a social security scheme Exclusion Criteria : * Persons protected by law (guardianship or trusteeship) or deprived of their freedom, * Pregnant women (contraindication to CB) or nursing mothers.

Primary outcome measure(s)

  • Observe how biological age evolves between pre-bariatric surgery and 1 year after bariatric surgery — 1 year
    Biological age will be estimated by measuring phenotypic age. The phenotypic age will be determined from the following variable: albumin, creatinine, fasting glucose, CRP, lymphocyte count, red cell size, alkaline phosphates, leukocyte count.

Trial sites (1)

FacilityCityRegionStatus
Nantes University Hospital Nantes Loire-Atlantique Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06625762 on ClinicalTrials.gov ↗ ← All trials in France