Intensive Care Unit Acquired WeaknessMuscle Weakness
Investigational drug(s) / intervention(s)
Early assessment of quadriceps muscle strength
Early assessment of quadriceps muscle strength: Patients will undergo non-invasive assessment of quadriceps muscle strength using manual dynamometry and 3D ultrasound. These assessments will be conducted regularly during their ICU stay to evaluate early recovery. The intervention is part of routine patient care and does not involve additional treatments or procedures.
Study summary
Patients in intensive care often develop acquired muscle weakness (ICUAW or Intensive Care Unit Acquired Weakness) due to immobilization and muscle atrophy. Early mobilization can help reduce weakness and improve functional recovery, but practices vary. Muscle strength assessment, particularly using the MRC (Medical Research Council) score, is crucial, though it has precision limitations. Additional methods, such as manual dynamometry and functional scales, are needed to better track muscle recovery. The quadriceps, important for function, requires early evaluation, but there is a lack of specific data in intensive care to predict medium-term functional recovery.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adults aged \> 18 years
* Hospitalized in an ICU
* Treated with invasive mechanical ventilation (MV) for at least 4 days during their stay (may be extubated at the time of inclusion)
* Conscious and cooperative patients: ability to respond appropriately to the following commands: open and close eyes, look at me, nod your head, stick out your tongue, raise your eyebrows when I count to five
* MRC score ≥ 3/5 for the "Leg Extension" function on either the left or right side
* Informed consent obtained (no opposition)
Exclusion Criteria:
* Pregnant or breastfeeding women
* Fracture or amputation of a lower limb
* Acute or chronic brain or spinal cord injury responsible for hemiplegia or paraplegia
* Unstable spinal injury
* Neurodegenerative or chronic neurological disease
* Guillain-Barré Syndrome
* Myasthenia Gravis
* Acute deep vein thrombosis of the lower limbs treated within the last 48 hours
* Pre-existing motor deficit in a lower limb before the ICU stay, of any cause
* Incarcerated or legally protected individuals (guardianship, curatorship)
* Individuals without social protection
Primary outcome measure(s)
Describe the evolution of quadriceps muscle recovery using manual dynamometry in patients under invasive mechanical ventilation in the ICU. — 3 months This study aims to describe the evolution of quadriceps muscle recovery in ICU patients under invasive mechanical ventilation, using manual dynamometry as a measurement tool. The recovery will be assessed periodically throughout the ICU stay to evaluate early muscle strength recovery.
Description of the evolution of the recovery of the rectus femoris muscle using 3D ultrasound in ICU patients treated with invasive mechanical ventilation. — 3 months after ICU discharge Change in the volume of the rectus femoris muscle measured by 3D ultrasound.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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