Blood test: A blood test (2 x 5 ml dry tubes) will be taken to analyze steroid profiles
urine sample: a 20 ml urine sample will be taken to analyze steroid profiles
vaginal sample: to characterize the microbiota.
Study summary
Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age. The etiology and pathophysiology of endometriosis is not completely understood to support effective treatment and prevention strategies. Despite the steroid dependency, little is known concerning the underlying metabolism of estrogen and other tightly related steroids. Moreover, shortening the long diagnostic delays is a major priority in endometriosis research.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
45 Years
Healthy volunteers
No
Inclusion Criteria:
* Women aged 18 to 45
* Free, informed and written consent from the patient to participate in the study
* Good understanding of the French language
* Patient affiliated to or benefiting from a social security or similar scheme
Specific inclusion criteria for each group:
Group 1. Controls.
* Women with no laparoscopically confirmed signs suggestive of deep endometriosis.
* No clinico-biological criteria in favour of a diagnosis of endometriotic disease, nor any radiological signs (ultrasound or MRI) suggestive of endometriosis.
Group 2. Cases of deep endometriosis.
* Newly diagnosed women (less than 12 months).
* Severe, deep endometriotic pathology with surgical indication (clinical examination, imaging tests, pre-operative findings).
Exclusion Criteria:
* Intercurrent diagnosis of pregnancy.
* Presence of other hormone-dependent pathologies (e.g. breast cancer, PCOS).
* Acute infection.
Primary outcome measure(s)
Identify steroid profiles associated with endometriosis — Sampling at inclusion visit Statistical associations between steroids and the presence of endometriosis.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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