complete surgeryIn vitro fertilization without surgery
complete surgery: complete surgery of colorectal deep infiltrating endometriosis
In vitro fertilization without surgery: IVF without endometriosis surgery
Study summary
The ENDOFERT Study is an open, multicenter, randomized, parallel-group, controlled trial. This study includes patients presenting colorectal DIE and infertility. Patients will be randomized in two parallel-groups; one group underwent complete surgery of colorectal DIE prior to ART and the other group underwent ART alone (ratio 1:1)
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
38 Years
Healthy volunteers
No
Inclusion Criteria:
* Primary and secondary infertility
* Indication for IVF
* Persistent pain related to endometriosis with analgesic medical treatment failure
* Persistent pain including at least one of the following digestive symptoms related to endometriosis: Dyschesia / Sub-occlusive syndrome / Rectal bleeding / Painful defecation
* Colorectal deep infiltrating endometriosis : Whatever lesion size / With at least rectal serosal involvement / Confirmed by MRI and 1 different investigation: vaginal ultrasound echography or coloscopic CT scan or rectal endoscope ultrasound
* Eligible for DIE surgery
Exclusion Criteria:
* Contraindication to pregnancy or to IVF
* Viral risk
* Previous IVF cycle(s)
* Previous colorectal surgery
* Need of myomectomy during surgery
* The use of oocytes donor
Primary outcome measure(s)
Clinical pregnancy after 2 IVF cycles — At the end of the 2nd IVF cycle (therefore at 6 weeks after each embryo transfer) Clinical pregnancy is defined as pregnancy at 6 weeks of gestation with ultrasound echographic confirmation.
An IVF cycle is defined as the transfer of all the embryos created via IVF after 1 oocytes puncture until a pregnancy confirmation or until the failure of the last embryo transfer. 2 embryos are transferred for each transfer steps.
The length of one cycle depend on the number of embryo transfer steps. It is usually between 2 and 9 months.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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