CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.

Condition(s) studied

Investigational drug(s) / intervention(s)

CBCT: Cone Beam Computed Tomography (CBCT) has a better sensitivity and sensibility to detect OIF.

Study summary

1\. Infective Endocarditis (IE) is a rare and serious disease with high morbidity and mortality; 2. Streptoccoci of oral origin are the second more frequent microorganisms responsible for IE; 3. Oral Infectious Foci (OIF) are underdetected using the current recommended clinical examination/Orthopantomogram (OPT) approach; 4. Cone Beam Computed Tomography (CBCT) has a better sensitivity and sensibility to detect OIF than OPT; 5. To date, no study has been performed to assess the potential benefit of a clinical examination/CBCT approach on the oral health status in IE patients.

Thus, conducting a randomized controlled trial is highly desirable to assess the potential impact of a clinical examination/CBCT approach on the oral health status of patients hospitalized for IE and potentially to reduce IE new episodes.

Eligibility

Primary outcome measure(s)

• Superiority of CBCT — Month 12
  Number of oral infectious foci detected using orthopantomogram versus Cone Beam Computer Tomography
• Superiority of CBCT — Month 12
  DFMT index comprising the number of decayed, filled and missing teeth
• Superiority of CBCT — Month 12
  Number of severe periodontitis sites

Trial sites (10)

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