Clinical Trials in Nedlands, Australia, 2026

Trials with a site in Nedlands

Status

Study

Lead sponsor

Phase

Enrol

Sites in Australia

Start

Not yet open

Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis

NCT07441408Pulmonary Fibrosis

DrugAdmilparant

Bristol-Myers Squibb

Phase 3

2,380

Camperdown, Chermside, Greenslopes, South Brisbane, Adelaide, Frankston, Murdoch, Nedlands

2026-12-16

Not yet open

A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma

NCT07728188Relapsed or Refractory Multiple Myeloma

DrugsEtentamig·Teclistamab·Carfilzomib·Pomalidomide

AbbVie

Phase 3

520

Wollongong, Benowa, South Brisbane, Melbourne, Richmond, Murdoch, Nedlands

2026-11-30

Not yet open

A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.

NCT07272642Imaging, Colorectal Cancer, Head and Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer

Radiopharm Theranostics, Ltd

Phase 1

Nedlands

2026-10-30

Not yet open

A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).

NCT07735637Newly Diagnosed Multiple Myeloma (NDMM)

DrugsASCT·AZD0120·Melphalan·Lenalidomide

AstraZeneca

Phase 3

750

Brisbane, Camperdown, Darlinghurst, Fitzroy, Melbourne, Nedlands

2026-08-25

Recruiting

A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease

NCT07737743Sjögren's Disease

DrugDDY391

Novartis Pharmaceuticals

Phase 2

344

Southport, Nedlands

2026-08-24

Not yet open

A Study to Test CRT-402 in Refractory Autoimmune Disease

NCT07778446Autoimmune Diseases, Systemic Lupus Erythematosus, Systemic Scleroderma, Myositis

Myeloid Therapeutics

Phase 1/2

Nedlands

2026-08-24

Recruiting

A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease

NCT07298421Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

100

Parkville, Nedlands

2026-08-18

Recruiting

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas

NCT07546812HER2-negative, Gastroesophageal Junction, Esophageal Adenocarcinoma, Gastric Adenocarcinoma

DrugsDenikitug·Ramucirumab·Nivolumab·Paclitaxel

Gilead Sciences

Phase 2

120

Camperdown, St Leonards, Herston, Bedford Park, Nedlands

2026-08-07

Not yet open

TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors

NCT07713732Small Cell Lung Cancer ( SCLC ), Neuroendocrine Cancer, Malignant Pleural Mesotheliomas (Mpm), Synovial Sarcomas

DrugVenetoclax

Treeline Biosciences, Inc.

Phase 1

120

Camperdown, Malvern, Nedlands

2026-07-25

Recruiting

A Phase I Study of CS5007 in Participants With Advanced Solid Tumors

NCT07622524Advanced Solid Tumors

CStone Pharmaceuticals

Phase 1

310

Darlinghurst, North Ryde, Waratah, South Brisbane, Fitzroy, Nedlands

2026-07-16

Recruiting

Study of D3L-002 in Subjects With Advanced Solid Tumors

NCT07667842Advanced Solid Tumor

D3 Bio (Wuxi) Co., Ltd

Phase 1

Macquarie Park, Nedlands

2026-07-14

Recruiting

Study of XmAb412 in Healthy Participants

NCT07713485Not Applicable - Healthy Adult Participants

Xencor, Inc.

Phase 1

128

Joondalup, Nedlands

2026-07-13

Recruiting

Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction

NCT07362446Myocardial Infarction, Reperfusion Injury, AMI, STEMI (ST Elevation MI)

Nyrada Pty Ltd

Phase 2

300

Kingswood, Liverpool, Adelaide, Epping, Frankston, Saint Albans, Nedlands, Perth

2026-07-02

Recruiting

The Efficacy and Safety of PRTX007-003 Combined With Pembrolizumab in Resectable Stage III Melanoma

NCT07565285Melanoma Stage III

DrugPembrolizumab

Primmune Therapeutics, Inc.

Phase 2

Waratah, Cairns, Greenslopes, Woolloongabba, Melbourne, Nedlands

2026-07-01

Recruiting

An Investigational Study of BG-75202 Alone and in Combination With Other Agents in Patients With Myeloid Malignancies

NCT07619287Myeloid Malignancy

DrugBG-75202

BeOne Medicines

Phase 1

118

Concord, Kogarah, Kurralta Park, Geelong, Heidelberg, Nedlands

2026-06-23

Recruiting

A Study of ARC-02 in B-cell NHL

NCT07691606B-cell Non Hodgkin Lymphoma

DrugRituximab

Taiho Oncology, Inc.

Phase 1

140

Clayton, Melbourne, Nedlands, Southport

2026-06-22

Recruiting

Imaging Study in Metastatic Clear Cell RCC.

NCT07671417Metastatic Clear Cell Renal Cell Carcinoma

RayzeBio, Inc.

Phase EARLY_PHASE1

Saint Leonards, Nedlands, Perth

2026-06-15

Recruiting

Imaging Study in Metastatic UC, HR+ and HER2- Breast Cancer, TNBC, and NSCLC

NCT07671092Metastatic Urothelial Carcinoma, Breast Cancer, TNBC - Triple-Negative Breast Cancer, Hormone Receptor Positive HER-2 Negative Breast Cancer

RayzeBio, Inc.

Phase EARLY_PHASE1

St Leonards, Nedlands, Perth

2026-06-15

Recruiting

A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

NCT07101328Lymphoma, Non-Hodgkin, B-cell Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular

Eli Lilly and Company

Phase 1

215

Melbourne, VIC, Nedlands

2026-05-28

Recruiting

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

NCT07492641HR+/HER2- Breast Cancer

DrugsBGB-43395·Ribociclib·Abemaciclib·Palbociclib

BeOne Medicines

Phase 3

1,056

Blacktown, Liverpool, Wollongong, Birtinya, Douglas, Melbourne, Murdoch, Nedlands

2026-05-22

Recruiting

Study of INCA036978 in Participants With Myeloproliferative Neoplasms

NCT07441694Myeloproliferative Neoplasms

Incyte Corporation

Phase 1

218

Concord, St Leonards, Auchenflower, East Melbourne, Nedlands

2026-05-11

Recruiting

Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)

NCT07509151Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV

DrugSurovatamig

AstraZeneca

Phase 3

420

Adelaide, Fitzroy, Heidelberg, Nedlands, Perth, Rockingham

2026-05-05

Recruiting

A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants

NCT07573462Pneumococcal Disease

DrugsPG4·Prevnar 20

Pfizer

Phase 3

2,400

Westmead, Brisbane, South Brisbane, Clayton, Parkville, Nedlands

2026-05-04

Recruiting

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

NCT07513376Non-small Cell Lung Cancer

DrugsPembrolizumab Formulated with Berahyaluronidase Alfa·Intismeran autogene

Merck Sharp & Dohme LLC

Phase 3

876

St Leonards, Brisbane, Nedlands

2026-05-04

Recruiting

A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression

NCT07546500Ovarian Cancer

DrugAzenosertib

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 3

420

Randwick, Adelaide, Nedlands

2026-04-17

Recruiting

A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis

NCT07158242Moderately to Severely Active Ulcerative Colitis

DrugAfimkibart

Hoffmann-La Roche

Phase 3

100

South Brisbane, Parkville, Nedlands

2026-04-15

Recruiting

Dose Escalation and Dose Expansion Study of MDX2003 in Patients With Different Types of Lymphoma

NCT07249905Lymphoma, Waldenström Macroglobulinemia (WM), DLBCL - Diffuse Large B Cell Lymphoma, PMBCL

ModeX Therapeutics, An OPKO Health Company

Phase 1/2

180

Richmond, Nedlands

2026-04-13

By invitation

An Extension of SKY-0515 in Participants With Huntington's Disease

NCT07537075Huntington's Disease (HD)

DrugSKY-0515

Skyhawk Therapeutics, Inc.

Phase 2/3

500

New Lambton Heights, Westmead, Herston, Adelaide, Caulfield South, Parkville, Nedlands

2026-04-10

Not yet open

Evaluating Ovarian Toxicity Outcomes Following Immunotherapy in Patients With Triple-Negative Breast Cancer (TNBC)

NCT07527819Triple Negative Breast Cancer (TNBC)

Peter MacCallum Cancer Centre, Australia

Observational

Camperdown, Sydney, Adelaide, Hobart, Box Hill, Clayton, Melbourne, Nedlands

2026-04-08

Recruiting

Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

NCT07297979Ewing Sarcoma

DrugXaluritamig

Amgen

Phase 1

Camperdown, Melbourne, Nedlands

2026-04-08

Recruiting

A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)

NCT06947941Alzheimer Disease, Psychosis

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

325

Macquarie Park, Nedlands

2026-03-25

Recruiting

Study in Advanced Solid Tumor Patients

NCT07300943Advanced Solid Tumor

Callio Therapeutics

Phase 1/2

306

Randwick, South Brisbane, Box Hill, Heidelberg, Melbourne, Nedlands

2026-03-19

Active, closed

Study of BW-50218 in Healthy Participants

NCT07401472Healthy Participants Study

DrugBW-50218

Shanghai Argo Biopharmaceutical Co., Ltd.

Phase 1

Adelaide, Nedlands

2026-03-12

Recruiting

A Study of Terbium 161 (161Tb)-RAD402 in Participants With CRPC

NCT07259213Castration-resistant Prostate Cancer

Radiopharm Theranostics, Ltd

Phase 1/2

Wollongong, Nedlands

2026-03-05

Recruiting

A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.

NCT07369076Amyotrophic Lateral Sclerosis (ALS)

Nura Bio

Phase 1/2

Concord, Randwick, Brisbane, Bedford Park, Caulfield South, Nedlands

2026-03-04

Recruiting

ADCX-020 for the Treatment of Patients With Locally Advanced or Metastatic Cancers

NCT07238075Advanced Malignancy, Advanced Solid Cancers, Metastatic Solid Tumors

Adcytherix SAS

Phase 1

290

Sydney, Birtinya, Southport, Adelaide, Nedlands

2026-02-23

Recruiting

Inhaled RB042 in Healthy Adult Volunteers, Healthy Adult Smokers and Patients With Chronic Obstructive Pulmonary Disease

NCT07285122Healthy, Healthy Smoker, COPD (Chronic Obstructive Pulmonary Disease), COPD

Atisama Therapeutics

Phase 1

105

Nedlands

2026-02-16

Recruiting

BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia

NCT07204990Endotracheal Extubation, Airway Anesthesia, Paediatric

Telethon Kids Institute

Not applicable

1,400

Nedlands

2026-02-06

Recruiting

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

NCT07258511Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

400

Box Hill, Brisbane, Clayton, Fitzroy, Melbourne, Murdoch, Nedlands, Southport

2026-02-04

Recruiting

Study of BPI-572270 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

NCT07435038Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors

Betta Pharmaceuticals Co., Ltd.

Phase 1/2

120

Blacktown, Randwick, Sydney, Bedford Park, Heidelberg, Nedlands

2026-01-29

Recruiting

A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma

NCT07309614Asthma Control

DrugDupilumab

Université de Sherbrooke

Phase 3

150

Nedlands

2026-01-29

Active, closed

A Phase I/II, Dose-finding Study to Assess the Safety, Reactogenicity, and Immunogenicity of a Broadly Protective Sarbecovirus Vaccine (GBP511) in Healthy Adults.

NCT07280858Healthy Participants, Sarbecovirus

DrugB)

SK Bioscience Co., Ltd.

Phase 1/2

368

Sydney, Joondalup, Nedlands

2026-01-28

Recruiting

A Study in Pediatric Participants With Congenital Adrenal Hyperplasia (Balance-CAH)

NCT07159841Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 2/3

153

Westmead, South Brisbane, Clayton, Nedlands

2026-01-22

Recruiting

A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors

NCT07263594Gastrointestinal Cancer

DualityBio Inc.

Phase 1/2

127

Randwick, South Brisbane, Nedlands

2026-01-20

Recruiting

Vorasidenib Maintenance for IDH Mutant Astrocytoma

NCT06809322IDH-mutant Grade 2 or 3 Astrocytoma

DrugVorasidenib

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

468

Bedford Park, Camperdown, Heidelberg, Hobart, Liverpool, Melbourne, Nedlands, St Leonards

2026-01-16

Recruiting

A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

NCT07253285Overweight, Obesity

DrugsCagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

460

Westmead, South Brisbane, Nedlands

2026-01-08

Recruiting

A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients With Advanced Solid Tumors

NCT07266428Advanced Solid Tumors

Ottimo Pharma Limited

Phase 1/2

170

Adelaide, Camperdown, Nedlands

2025-12-17

Recruiting

A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)

NCT07247110Malignant Neoplasm

DrugsCetuximab·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 1

250

Sydney, Clayton, Melbourne, Nedlands

2025-12-16

Recruiting

A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

NCT07221474Squamous Non-small Cell Lung Cancer

DrugsIntismeran autogene·Nab-paclitaxel·Keytruda·Paclitaxel

Merck Sharp & Dohme LLC

Phase 2

180

Westmead, Woolloongabba, Nedlands

2025-12-12

Recruiting

A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia

NCT07144163Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 3

150

Herston, Woolloongabba, Adelaide, Parkville, Nedlands

2025-12-11

Recruiting

A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors

NCT07226349Advanced Solid Tumor

DrugsBGB-43395·Fulvestrant

BeOne Medicines

Phase 1

105

Blacktown, St Leonards, Auchenflower, Malvern, Melbourne, Nedlands

2025-12-11

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

NCT07155187Non-Small Cell Lung Cancer

DrugsTelisotuzumab Adizutecan·Osimertinib

AbbVie

Phase 2/3

490

Garran, Kogarah, South Brisbane, Hobart, Fitzroy, St Albans, Nedlands

2025-12-10

Recruiting

Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Iptacopan in Pediatric Patients With Primary IgAN

NCT06994845Primary Immunoglobulin A Nephropathy (IgAN)

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

Brisbane, Nedlands

2025-11-27

Recruiting

Safety and Efficacy of Tarperprumig in Adult Participants With Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis

NCT07160608Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Alexion Pharmaceuticals, Inc.

Phase 2

Clayton, Heidelberg, Nedlands, Wollongong

2025-11-26

Recruiting

SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

NCT07187531Type 1 Diabetes

SAb Biotherapeutics, Inc.

Phase 2

159

Brisbane, Nedlands, Parkville, St Leonards, Westmead

2025-11-25

Recruiting

Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation

NCT07211958Acute Myeloid Leukemias

DrugRevumenib

Syndax Pharmaceuticals

Phase 3

468

Kingswood, Kogarah, Randwick, South Brisbane, Melbourne, Nedlands, Perth, Gosford

2025-11-25

Recruiting

Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MT-304 in Adults With Advanced HER2-Expressing Solid Tumors

NCT07334119HER2-Expressing Solid Tumors

DrugNivolumab

Myeloid Therapeutics

Phase 1

Darlinghurst, Randwick, Waratah, South Brisbane, Adelaide, Melbourne, Nedlands

2025-11-25

Recruiting

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

NCT07174310Parkinson's Disease

DrugPrasinezumab

Hoffmann-La Roche

Phase 3

900

Kogarah, Westmead, Woolloongabba, Clayton, Parkville, Prahan, Nedlands

2025-11-24

Active, closed

A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment

NCT07036523Idiopathic Pulmonary Fibrosis

Boehringer Ingelheim

Phase 2

Chermside, Clayton, Nedlands

2025-11-13

Recruiting

AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL

NCT07215585Large B-cell Lymphoma

DrugsR-mini-CHOP·Surovatamig

AstraZeneca

Phase 3

420

Clayton, Macquarie University, Melbourne, Nedlands, Waratah

2025-11-11

Recruiting

Study of PRA-216 in Healthy Participants and Participants With Mild-to-Moderate Asthma

NCT07245368Mild to Moderate Asthma

Prana Therapies Inc

Phase 1/2

Botany, Camberwell, Clayton, Joondalup, Nedlands

2025-11-04

Recruiting

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

NCT07085767Breast Cancer, Locally Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Ribociclib·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

1,000

Sydney, Waratah, South Brisbane, Adelaide, Clayton, Geelong, Heidelberg, Nedlands

2025-11-03

Recruiting

An Initial Evaluation of AN8025 in Solid Tumors

NCT07639047Advanced Solid Tumor (Phase 1)

Adlai Nortye Biopharma Co., Ltd.

Phase 1

Nedlands

2025-11-01

Recruiting

Study to Collect Real-world Performance and Safety Data on Penumbra System® in Population With Acute Ischemic Stroke (AIS).

NCT07107022Acute Ischemic Stroke (AIS)

Penumbra Inc.

Observational

200

Nedlands

2025-11-01

Recruiting

A Study of ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC

NCT07244705Colorectal Cancer (Diagnosis), Colorectal Cancer Metastatic, Colorectal Cancer (CRC), Immunotherapy

DrugsAvastin·Tislelizumab·Bevacizumab

Anbogen Therapeutics, Inc.

Phase 1/2

Liverpool, Macquarie Park, Randwick, Greenslopes, Woodville South, Clayton, Heidelberg, Nedlands

2025-11

Recruiting

Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food Allergy

NCT07220811Ig-E Mediated Food Allergy

DrugOzureprubart

RAPT Therapeutics, Inc., a member of the GSK plc group of companies

Phase 2

100

Darlinghurst, Westmead, South Brisbane, North Adelaide, Clayton, Parkville, Nedlands, Perth

2025-10-22

Recruiting

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

NCT07184931Crohn's Disease

DrugDuvakitug

Sanofi

Phase 3

980

Birtinya, Nedlands, South Brisbane

2025-10-01

Recruiting

A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

NCT07008118Myeloproliferative Neoplasms

Incyte Corporation

Phase 1

120

Sydney, Adelaide, Melbourne, Nedlands

2025-10-01

Recruiting

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

NCT07028853Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

1,000

Orange, Wahroonga, South Brisbane, Kurralta Park, Nedlands

2025-09-28

Recruiting

A Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors

NCT07141706Advanced/Metastatic Solid Tumors

DualityBio Inc.

Phase 1

253

Liverpool, Randwick, Westmead, Nedlands

2025-09-23

Recruiting

A Study of YL242 in Subjects With Advanced Solid Tumors

NCT07197827Advanced Solid Tumor

DrugsAdrucil·Pembrolizumab

MediLink Therapeutics (Suzhou) Co., Ltd.

Phase 1/2

424

Liverpool, Darlinghurst, Fitzroy, Heidelberg, Nedlands

2025-09-22

Recruiting

A Phase II Study of Intravitreal KIO-301 in Patients With Late-stage Retinitis Pigmentosa

NCT06628947Retinitis Pigmentosa

Kiora Pharmaceuticals, Inc.

Phase 2

Sydney, Woolloongabba, Adelaide, East Melbourne, Nedlands

2025-08-29

Recruiting

A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as Monotherapy or in Combination With BNT327 in Adults With Advanced Solid Tumors

NCT07147348Advanced Solid Tumor

DrugPumitamig

BioNTech SE

Phase 1/2

375

Adelaide, Clayton, Melbourne, Nedlands, Randwick

2025-08-27

Recruiting

A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)

NCT07058077Heterozygous Familial Hypercholesterolemia (HeFH)

DrugEnlicitide Decanoate

Merck Sharp & Dohme LLC

Phase 2/3

153

Clayton, Nedlands

2025-08-21

Recruiting

Open-label Extension Study in Participants With Early Alzheimer's Disease

NCT07105709Alzheimer's Disease

GlaxoSmithKline

Phase 2

220

Macquarie Park, Nedlands

2025-08-14

Recruiting

A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC) [EMBOLD SCLC-301]

NCT07099898Neoplasms, Lung

DrugsRis-Rez·Topotecan

GlaxoSmithKline

Phase 3

420

Blacktown, St Leonards, Nedlands

2025-08-11

Recruiting

Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT06896916Multiple Myeloma

DrugsEtentamig·Iberdomide

AbbVie

Phase 1

135

Blacktown, Wollongong, Melbourne, Nedlands

2025-08-07

Recruiting

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

NCT07094516Alzheimer's Disease

DrugVHB937

Novartis Pharmaceuticals

Phase 2

407

Camperdown, Kogarah, Box Hill, Heidelberg, Nedlands

2025-08-07

Recruiting

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

NCT07098338Non-Small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Datopotamab deruxtecan

AstraZeneca

Phase 2

278

Heidelberg, Nedlands, Woodville

2025-08-07

Recruiting

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

NCT06757634Breast Cancer

DrugsGedatolisib·Ribociclib·Palbociclib·Letrozole

Celcuity Inc

Phase 3

1,180

Adelaide, Nedlands, Southport, Wahroonga, Westmead, Woodville

2025-07-24

Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

NCT07060807Breast Neoplasms

DrugsLiposomal doxorubicin·Patritumab deruxtecan·Xeloda·Abraxane

Merck Sharp & Dohme LLC

Phase 3

1,000

Blacktown, Camperdown, Clayton, Melbourne, Nedlands

2025-07-21

Recruiting

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

NCT07082738Chronic Obstructive Pulmonary Disease (COPD)

AstraZeneca

Phase 2

987

Cairns, Nedlands, Norwood, Osborne Park, South Brisbane, Wollongong

2025-06-27

Recruiting

Study of DT-7012 as a Single Agent and in Combination With an Immune Checkpoint Inhibitor in Participants With Advanced Solid Tumors

NCT06819735Advanced Solid Tumors

DrugDT-7012

Domain Therapeutics Australia Pty Ltd

Phase 1/2

125

North Ryde, Adelaide, Frankston, Malvern, Nedlands

2025-06-25

Active, closed

Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)

NCT07003919Allergy, Peanut Allergy

DBV Technologies

Phase 3

480

Westmead, South Brisbane, Parkville, Richmond, Nedlands

2025-06-24

Active, closed

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

NCT07037771Homozygous Familial Hypercholesterolemia

Arrowhead Pharmaceuticals

Phase 3

Camperdown, Saint Leonards, Heidelberg, Nedlands

2025-06-17

Active, closed

REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome

NCT06914609Angelman Syndrome

DrugObudanersen

Ionis Pharmaceuticals, Inc.

Phase 3

156

South Brisbane, Heidelberg, Nedlands, Randwick

2025-06-10

Recruiting

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

NCT06808984Agitation, Alzheimer Disease

DrugIrafamdastat

Celgene

Phase 2

120

Macquarie Park, Daw Park, Wangaratta, Nedlands, Darlinghurst

2025-06-09

Recruiting

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

NCT06782490Multiple Sclerosis Spasticity

DrugIrafamdastat

Celgene

Phase 2

200

Newcastle, Sydney, Kent Town, Box Hill, Heidelberg, Parkville, Nedlands

2025-06-05

Recruiting

A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

NCT06961006Malignant Melanoma

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 2

160

Blacktown, Wollstonecraft, Nedlands

2025-05-29

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

NCT06682988Advanced High-Grade Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancers

DrugsMIRV·Mirvetuximab Soravtansine

AbbVie

Phase 2

110

Blacktown, Lambton Heights, Brisbane, Chermside, Ballarat, Clayton, Nedlands

2025-05-28

Active, closed

Study of SKY-0515 for Safety, Efficacy, and Pharmacodynamics in Participants With Huntington's Disease

NCT06873334Huntington Disease, Huntingtons Disease

DrugSKY-0515

Skyhawk Therapeutics, Inc.

Phase 2/3

120

New Lambton Heights, Westmead, Herston, Adelaide, Launceston, Caulfield South, Parkville, Nedlands

2025-05-27

Recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

NCT06952504Endometrial Cancer

DrugsSacituzumab tirumotecan·Docetaxel·Keytruda·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

1,123

Blacktown, Brisbane, Melbourne, Nedlands

2025-05-22

Recruiting

A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes Mellitus

NCT06937203Obesity, Diabetes Mellitus, Type 2

Arrowhead Pharmaceuticals

Phase 1/2

150

Morayfield, Nedlands

2025-05-09

Recruiting

Safety, Tolerability and Efficacy of Intravitreal KIO-104 in Patients With Macular Edema

NCT06825702Macular Edema

Kiora Pharmaceuticals, Inc.

Phase 2

Sydney, Westmead, Adelaide, Hobart, East Melbourne, Nedlands

2025-05-01

Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

NCT06820463Metastatic Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Panitumumab·Leucovorin·Fluorouracil

AbbVie

Phase 2

390

Sydney, South Brisbane, Woodville South, Heidelberg, Nedlands

2025-04-24

Recruiting

A Study of Intravenous CPTX2309 in Healthy Participants and Participants With Moderate to Severe Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE)

NCT06917742Healthy Volunteers, Rheumatoid Arthritis, Systemic Lupus Erythematosus

Capstan Therapeutics

Phase 1

Herston, Bayswater, Nedlands

2025-04-09

Recruiting

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

NCT06822790Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

869

Box Hill, Clayton, Heidelberg Heights, Nedlands

2025-04-09

Recruiting

Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

NCT06801834Extensive Stage Small Cell Lung Cancer (ES-SCLC)

DrugsAmrubicin·Lurbinectedin·Topotecan·Sacituzumab Govitecan

Gilead Sciences

Phase 3

695

New South Wales, Queensland, Southport, Adelaide, Fitzroy, Nedlands

2025-04-04

Recruiting

Tissue Repair Gel in Venous Leg Ulcers in AU/US

NCT06707103Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis

DrugTR987

TR Therapeutics

Phase 3

312

Camperdown, Kogarah, Orange, Sydney, Bendigo, Ivanhoe, Shepparton, Nedlands

2025-04

Recruiting

A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL

NCT06854653CTCL

Prescient Therapeutics, Ltd.

Phase 2

115

Westmead, Melbourne, Nedlands

2025-03-28

Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

NCT06989112Endometrial Cancer

DrugsTaxotere·Rilvegostomig·Paraplatin·Taxol

AstraZeneca

Phase 3

600

Blacktown, East Melbourne, Nedlands, South Brisbane

2025-03-27

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

NCT06878261Chronic Obstructive Pulmonary Disease (COPD)

DrugTezepelumab

AstraZeneca

Phase 3

990

Coffs Harbour, Frankston, Garran, Nedlands, New Lambton, Spearwood, Wollongong, Woodville South

2025-03-25

Active, closed

A Study of JNJ-90189892 for Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Neoplasms

NCT06651229Leukemia, Myeloid, Acute, Myelodysplastic Neoplasms

DrugsAzacitadine·Venetoclax

Janssen Research & Development, LLC

Phase 1

Concord, Melbourne, Nedlands

2025-03-21

Active, closed

A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

NCT06795048Neovascular Age-related Macular Degeneration (nAMD)

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Phase 4

274

Strathfield, Sydney, Adelaide, East Melbourne, Rowville, Nedlands

2025-03-14

Recruiting

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

NCT06940739Unresectable Melanoma, Metastatic Melanoma, Ocular Melanoma

Iovance Biotherapeutics, Inc.

Phase 1/2

Greenslopes, Nedlands

2025-03-11

Recruiting

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

NCT06742996Mantle Cell Lymphoma, B Cell Lymphoma

DrugsSonrotoclax·Zanubrutinib

BeOne Medicines

Phase 3

300

St Leonards, Birtinya, Box Hill, Clayton, Cooloongup, Nedlands, West Perth

2025-03-05

Recruiting

Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment

NCT06841055Non-small Cell Lung Cancer

DrugsPumitamig·Docetaxel

BioNTech SE

Phase 2

Liverpool, Woolloongabba, Adelaide, Hobart, Nedlands

2025-03-03

Recruiting

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

NCT06804824Advanced Solid Tumors

DrugsSotorasib·Trametinib

Vividion Therapeutics, Inc.

Phase 1

220

Adelaide, Nedlands

2025-02-25

Recruiting

SNV4818 in Participants With Advanced Solid Tumors

NCT06736704Advanced Solid Tumors

DrugsPalbociclib·Fulvestrant

Pikavation Therapeutics, Inc.

Phase 1/2

320

Camperdown, Randwick, Clayton, Melbourne, Nedlands

2025-02-20

By invitation

GENomic Predictors in A Multi-Ethnic Population With Kidney Disease Study

NCT06828562Kidney Disease

Western Sydney Local Health District

Observational

500

Sydney, Westmead, Nedlands

2025-02-10

Recruiting

BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer

NCT06756932Hormone-receptor-positive Breast Cancer, HER2-negative Breast Cancer, Metastatic Breast Cancer

DrugsBGB-43395·Fulvestrant

BeOne Medicines

Phase 1

120

Darlinghurst, Waratah, Birtinya, Melbourne, St Albans, Nedlands

2025-02-04

Recruiting

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

NCT06564038Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma, Large B-cell Lymphoma

DrugsSurovatamig·Acalabrutinib·Vincristine·Doxorubicin

AstraZeneca

Phase 1/2

408

Heidelberg, Melbourne, Nedlands

2025-01-30

Recruiting

A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.

NCT06697184Chronic Lymphocytic Leukemia, CLL, Mantle Cell Lymphoma, MCL

DrugsSonrotoclax·Zanubrutinib

BeOne Medicines

Phase 1/2

258

Blacktown, Adelaide, Malvern, Melbourne, Cooloongup, Nedlands

2025-01-23

Active, closed

Study to Evaluate Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-291 Moves Through the Body in Adult Participants With Non-Hodgkin's Lymphoma

NCT06667687Non-Hodgkin's Lymphoma

AbbVie

Phase 1

Fitzroy Melbourne, Nedlands

2025-01-16

Recruiting

An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors

NCT06589596Advanced Solid Tumor

DrugBGB-58067

BeOne Medicines

Phase 1

525

Blacktown, Woolloongabba, Clayton, Heidelberg, Nedlands

2025-01-10

By invitation

A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring

NCT06788509Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes

DrugsJNJ-75348780·JNJ-87801493·JNJ-80948543·Ibrutinib

Janssen Research & Development, LLC

Phase 1

120

Macquarie University, Melbourne, Nedlands, Randwick

2024-12-30

Active, closed

A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma

NCT06679985Hepatocellular Carcinoma

DrugsToripalimab·Bevacizumab

Coherus Oncology, Inc.

Phase 2

Herston, Bankstown, Melbourne, Darlinghurst, Nedlands

2024-12-20

Recruiting

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

NCT06667908Carcinoma, Non-Small-Cell Lung

DrugsJNJ-90301900·Durvalumab

Johnson & Johnson Enterprise Innovation Inc.

Phase 2

130

Herston, Nedlands, North Ryde, Parkville

2024-12-06

Recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

NCT06465953Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes (MDS)

DrugsIvosidenib·Azacitidine

Institut de Recherches Internationales Servier

Phase 3

Adelaide, Clayton, Epping, Liverpool, Nedlands, Waratah

2024-12-03

Recruiting

Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

NCT06526793B-cell Non-Hodgkin Lymphoma, Follicular Lymphoma (FL), Large B-Cell Lymphoma (LBCL)

DrugSurovatamig

AstraZeneca

Phase 2

270

Heidelberg, Kogarah, Macquarie University, Nedlands

2024-11-27

Recruiting

A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

NCT06634589B-cell Malignancy, Relapsed Cancer, Refractory Cancer, B-cell Lymphoma

DrugsTacabrutideg·Mosunetuzumab·Sonrotoclax·Glofitamab

BeOne Medicines

Phase 1/2

Kogarah, South Brisbane, Clayton, Melbourne, Nedlands

2024-11-27

Recruiting

ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

NCT06597721Advanced Solid Tumor, PDAC, HNSCC

Adcendo ApS

Phase 1

210

Macquarie Park, Randwick, Bedford Park, Frankston, Malvern, Melbourne, Nedlands

2024-11-25

Active, closed

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older

NCT06460506Cystic Fibrosis

DrugELX/TEZ/IVA

Vertex Pharmaceuticals Incorporated

Phase 3

Nedlands, Parkville, South Brisbane

2024-11-21

Active, closed

A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)

NCT06422884Idiopathic Pulmonary Fibrosis, Progressive Fibrosing Interstitial Lung Disease

DrugTaladegib

Endeavor Biomedicines, Inc.

Phase 2

213

Camperdown, Macquarie Park, Brisbane, South Brisbane, Box Hill, Nedlands

2024-11-15

Recruiting

Study of IMC-P115C in Advanced PRAME-Positive Cancers

NCT07156136PRAME Positive, Cancer, HLA-A*02:01-positive

Immunocore Ltd

Phase 1

140

Adelaide, Nedlands, Wollstonecraft

2024-11-07

Recruiting

An Open Label Dose Finding Study of PTT-4256 in Patients With Solid Tumours (RAISIC-1).

NCT06634849Advanced Solid Tumor

Pathios Therapeutics Pty Ltd

Phase 1/2

Blacktown, Randwick, Adelaide, Heidelberg, Nedlands

2024-11-04

Active, closed

A Study of ZW191 in Participants With Solid Tumors

NCT06555744Advanced Solid Tumors

Zymeworks BC Inc.

Phase 1

145

Nedlands, St Leonards

2024-10-30

Recruiting

A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants

NCT06663332Crohns Disease, Colitis, Ulcerative, Arthritis, Psoriatic, Arthritis, Juvenile

DrugGuselkumab

Janssen Research & Development, LLC

Phase 3

196

Nedlands, South Brisbane, Westmead

2024-10-29

Active, closed

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

NCT06413706Glioma

DrugsAbemaciclib·Temozolomide

Eli Lilly and Company

Phase 2

Brisbane, Nedlands, Westmead

2024-10-25

Active, closed

Phase I Study of WJ47156 Monotherarpy and in Combination With Other Therapy in Advanced Solid Tumors

NCT06571422Advanced Malignant Solid Tumors

DrugsJS207·JS001·Bevacizumab

Shanghai Junshi Bioscience Co., Ltd.

Phase 1

Sydney, Brisbane, Adelaide, Nedlands

2024-10-23

Active, closed

Long-term Extension Study of Ulviprubart (ABC008) in Subjects With Inclusion Body Myositis

NCT06450886Inclusion Body Myositis (IBM)

Abcuro, Inc.

Phase 2/3

270

Saint Leonards, Herston, Nedlands

2024-10-21

Recruiting

Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis

NCT07612280Essential Thrombocythemia (ET), Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN), Myeloproliferative Neoplasms (MPN)

Jubilant Therapeutics Inc.

Phase 1/2

Sydney, Adelaide, Melbourne, Perth, Nedlands

2024-10-21

Recruiting

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

NCT06623422Carcinoma, Non-Small-Cell Lung

DrugsIntismeran autogene·Pemetrexed·Gemcitabine·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

680

Waratah, Southport, Woolloongabba, Ballarat, Nedlands

2024-10-21

Recruiting

Study of BG-T187 Alone and in Combination With Other Therapeutic Agents in Participants With Advanced Solid Tumors

NCT06598800Advanced Solid Tumor

BeOne Medicines

Phase 1

153

Blacktown, North Ryde, Malvern, Nedlands

2024-10-18

Recruiting

Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

NCT06619990Ulcerative Colitis (UC)

Xencor, Inc.

Phase 1/2

270

Adelaide, Joondalup, Melbourne, Nedlands, South Brisbane, Southport, Wollongong

2024-10-10

Recruiting

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT06417814Metastatic Non-small Cell Lung Cancer

DrugsTagrisso·Datopotamab deruxtecan·Osimertinib·Pemetrexed

AstraZeneca

Phase 3

744

Fitzroy, Heidelberg, Kogarah, Liverpool, Nedlands, Port Macquarie, St Leonards, Westmead

2024-10-04

Recruiting

A Study of BG-C477 in Participants With Advanced Solid Tumors

NCT06596473Advanced Solid Tumors

DrugTislelizumab

BeOne Medicines

Phase 1

310

Blacktown, Frenchs Forest, Birtinya, Adelaide, Melbourne, Nedlands

2024-10-03

Active, closed

To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications

NCT06553027Parkinson Disease

Cerevance

Phase 3

330

Darlinghurst, Kogarah, Sydney, Woolloongabba, Cheltenham, Melbourne, Nedlands

2024-09-20

Recruiting

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

NCT06542250B-cell Malignancies

DrugAZD5492

AstraZeneca

Phase 1/2

174

Melbourne, Nedlands

2024-09-18

Active, closed

A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis

NCT06431373Uveitis, Posterior, Uveitis, Intermediate, Uveitis

Priovant Therapeutics, Inc.

Phase 3

371

Sydney, East Melbourne, Nedlands

2024-09-11

Recruiting

First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

NCT06554795Solid Tumor, Adult

DualityBio Inc.

Phase 1/2

360

North Ryde, Randwick, Nedlands

2024-09-03

Active, closed

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

NCT06413498Multiple Myeloma

DrugsAnitocabtagene Autoleucel·Carfilzomib·Pomalidomide·Bortezomib

Kite, A Gilead Company

Phase 3

452

Camperdown, St Leonards, Adelaide, Richmond, Nedlands

2024-08-23

Recruiting

Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors

NCT06535607Sub-study 1 Cervical Cancer (Volrustomig Monotherapy), Sub-study 2 Head and Neck Squamous Cell Carcinoma (Volrustomig Monotherapy), Sub-study 3 Head and Neck Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy), Sub-study 4 Esophageal Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy)

DrugsVolrustomig·Adrucil·Paclitaxel·Cisplatin

AstraZeneca

Phase 2

257

Clayton, Nedlands

2024-08-22

Active, closed

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

NCT06533059Cancer, Breast Cancer, Endometrial Cancer, Metastatic Cancer

Alterome Therapeutics, Inc.

Phase 1

110

Randwick, Malvern, Nedlands

2024-08-22

Recruiting

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

NCT06467357Biliary Tract Cancer

DrugsRilvegostomig·Trastuzumab deruxtecan·Durvalumab·Gemcitabine

AstraZeneca

Phase 3

620

Chermside, Clayton, Concord, Nedlands

2024-08-12

Recruiting

A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

NCT06549595Untreated Follicular Lymphoma

DrugsSurovatamig·R-Chop

AstraZeneca

Phase 3

1,018

Clayton, Darlinghurst, Garran, Heidelberg, Macquarie University, Nedlands

2024-08-07

Active, closed

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

NCT06459180Cervical Cancer

DrugsTisotumab Vedotin·Vinorelbine·Topotecan·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

686

Sydney, Herston, Clayton, Melbourne, Nedlands

2024-07-24

Active, closed

A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease

NCT06544616Alzheimer Disease

Janssen Pharmaceutica N.V., Belgium

Phase 2

Carlton, Chermside, Darlinghurst, Ivanhoe, Kogarah, Macquarie Park, Nedlands

2024-07-22

Recruiting

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

NCT06127407Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

DrugIvosidenib

Servier Bio-Innovation LLC

Phase 3

136

Bedford Park, Camperdown, Fitzroy, Nedlands, Woolloongabba

2024-07-09

Recruiting

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

NCT06465069Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm

Eli Lilly and Company

Phase 1

420

Darlinghurst, Nedlands

2024-07-01

Active, closed

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

NCT06496178Head and Neck Squamous Cell Carcinoma

DrugPetosemtamab

Merus B.V.

Phase 3

621

Darlinghurst, Herston, Melbourne, Nedlands, Saint Leonards, Sydney

2024-06-25

Recruiting

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

NCT06428409Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer

DrugsSacituzumab tirumotecan·Leucovorin·Fluorouracil·Adrucil

Merck Sharp & Dohme LLC

Phase 1/2

220

Westmead, Brisbane, East Melbourne, Frankston, Nedlands

2024-06-20

Recruiting

A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

NCT06455449Polymyositis, Dermatomyositis

AstraZeneca

Phase 3

240

Camperdown, Nedlands, New Lambton, Southport, Woodville South

2024-06-20

Recruiting

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

NCT06500273Large B-cell Lymphoma

DrugsFludara·Cytoxan·Fludarabine·Cyclophosphamide

Allogene Therapeutics

Phase 2

250

Auchenflower, Hobart, Clayton, Fitzroy, Heidelberg, Nedlands

2024-06-18

Recruiting

AMT-676 in Patients With Advanced Solid Tumors

NCT06400485Advanced Solid Tumors

DrugAMT-676

Multitude Therapeutics Inc.

Phase EARLY_PHASE1

Randwick, Macquarie, Greenslopes, Melbourne, Nedlands

2024-06-18

Recruiting

A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections

NCT06056297Neutropenia

X4 Pharmaceuticals

Phase 3

176

Nedlands, Southport, Wendouree

2024-06-06

Active, closed

Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab

NCT06211036Extensive-Stage Small-Cell Lung Cancer, Small-Cell Lung Cancer

DrugsTarlatamab·Durvalumab

Amgen

Phase 3

563

Camperdown, Wollongong, Greenslopes, Adelaide, Clayton, Nedlands

2024-06-05

Recruiting

IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

NCT06112314Advanced Melanoma

DrugsBrenetafusp·Relatlimab·Opdivo·Nivolumab

Immunocore Ltd

Phase 3

680

Waratah, Greenslopes, Nedlands, Heidelberg, North Melbourne, Wollstonecraft, Woolloongabba

2024-06-05

Recruiting

A Study to Investigate APL-4098 Alone and in Combination in Adults With AML or MDS

NCT06372717Acute Myeloid Leukemia Refractory, Myelodysplastic Syndrome Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts, Acute Myeloid Leukemia, in Relapse

Apollo Therapeutics Ltd

Phase 1

100

Clayton, Fitzroy, Melbourne, Nedlands, Perth

2024-06-04

Recruiting

Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

NCT06479135Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis, Primary Myelofibrosis

DrugsNavtemadlin·Jakavi·Ruxolitinib

Kartos Therapeutics, Inc.

Phase 3

600

Hobart, Nedlands, Adelaide, Clayton, Douglas, Gosford, Kogarah, Melbourne

2024-06-03

Recruiting

A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers

NCT05509153Huntington Disease

DrugN-Acetylcysteine

Western Sydney Local Health District

Phase 2

160

Westmead, Herston, Parkdale, Parkville, Nedlands

2024-06-01

Recruiting

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

NCT06345729Non-small Cell Lung Cancer

DrugsCalderasib·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

600

Camperdown, Urraween, Frankston, Nedlands

2024-05-24

Recruiting

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

NCT06343402Non-small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer, NSCLC, KRAS G12C

DrugsBBO-10203·Pembrolizumab

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Phase 1

350

Darlinghurst, Bedford Park, Woodville South, Frankston, Melbourne, Nedlands

2024-05-22

Active, closed

A Study of Revumenib in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias

NCT06226571Acute Myeloid Leukemias

DrugRevumenib

Syndax Pharmaceuticals

Phase 1

Epping, Perth, Adelaide, Melbourne, Nedlands

2024-05-21

Active, closed

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

NCT06393712Cerebral Amyloid Angiopathy

DrugsMivelsiran·Aln-App

Alnylam Pharmaceuticals

Phase 2

210

Adelaide, Brisbane, Heidelberg, Nedlands, Parkville

2024-05-17

Active, closed

Evaluating Efficacy and Safety of CBD TPM Capsules for Use in Insomnia

NCT05840822Insomnia

DrugCannabidiol (CBD)

Avecho Biotechnology

Phase 3

519

North Sydney, Sydney, Southport, Clayton, Nedlands

2024-05-16

Active, closed

Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP

NCT06079359Hypophosphatasia

DrugALXN1850

Alexion Pharmaceuticals, Inc.

Phase 3

Nedlands, Parkville

2024-05-14

Recruiting

Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

NCT06384352Advanced Solid Tumors

DrugsPembro·Pemetrexed·Cisplatin·Carboplatin

MediLink Therapeutics (Suzhou) Co., Ltd.

Phase 1

500

Gosford, Nedlands, Melbourne

2024-05-01

Active, closed

A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)

NCT06346067Advanced or Metastatic NRAS-mutant Melanoma

DrugsNaporafenib·Temodar·Dacarbazine·Trametinib

Erasca, Inc.

Phase 3

Waratah, Southport, Woolloongabba, Melbourne, Nedlands

2024-04-29

Active, closed

Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

NCT05972551Osteogenesis Imperfecta

DrugRomosozumab

Amgen

Phase 3

111

Clayton, Nedlands

2024-04-22

Recruiting

Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors

NCT06233942Advanced Solid Tumor

DrugsTislelizumab·Bevacizumab

BeOne Medicines

Phase 1

308

Blacktown, North Ryde, Wollongong, Woolloongabba, Clayton, Malvern, Melbourne, Nedlands

2024-04-12

Active, closed

A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

NCT06329401Pulmonary Fibrosis, Progressive Pulmonary Fibrosis, Pulmonary Fibrosis Secondary to Systemic Sclerosis, Pulmonary Fibrosis, Interstitial Lung Disease

DrugPirfenidone

Avalyn Pharma Inc.

Phase 2

375

Camperdown, Kingswood, New Lambton, Sydney, Westmead, Nedlands, Brisbane, Footscray

2024-04-03

Active, closed

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

NCT06254950Ulcerative Colitis

DrugZasocitinib

Takeda

Phase 2

213

Sydney, South Brisbane, Bedford Park, Woodville, Melbourne, Nedlands, Perth, Murdoch

2024-03-29

Active, closed

A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)

NCT06305767Bladder Cancer

DrugsIntismeran autogene·Enfortumab Vedotin·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 1/2

230

Macquarie University, Westmead, South Brisbane, Nedlands

2024-03-28

Active, closed

Safety, Tolerability, PK and PD of ADX-850 in Participants With Hypertension

NCT06205628Hypertension, Hypertension,Essential

ADARx Pharmaceuticals, Inc.

Phase 1

Adelaide, Nedlands, Perth

2024-03-21

Recruiting

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

NCT06072781Low Grade Serous Ovarian Cancer

DrugsAvutometinib·Defactinib·Pegylated liposomal doxorubicin·Anastrozole

Verastem, Inc.

Phase 3

270

Randwick, Auchenflower, Adelaide, Melbourne, Nedlands

2024-03-18

Recruiting

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

NCT05923073Crohn's Disease

DrugsTremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

120

Nedlands, South Brisbane, Westmead

2024-03-13

Active, closed

NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)

NCT05996003Duchenne Muscular Dystrophy, Exon 44, DMD

DrugBrogidirsen

NS Pharma, Inc.

Phase 2

South Brisbane, Nedlands

2024-02-22

Recruiting

A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

NCT06283966COPD (Chronic Obstructive Pulmonary Disease)

AstraZeneca

Phase 3

5,000

Birtinya, Cairns, Chermside, Coffs Harbour, Dubbo, Nedlands, Port Macquarie, Spearwood

2024-02-21

Recruiting

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

NCT06244771Advanced Solid Tumors With KRAS G12C Mutations, Solid Tumor, Adult, Unresectable Solid Tumor, Metastatic Solid Tumor

Frontier Medicines Corporation

Phase 1/2

403

Macquarie Park, Southport, Kurralta Park, North Adelaide, Box Hill, Nedlands

2024-02-12

Recruiting

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

NCT06152575Multiple Myeloma

DrugsElotuzumab·Elranatamab·Carfilzomib·Pomalidomide

Pfizer

Phase 3

492

Blacktown, Concord, Birtinya, Brisbane, Fitzroy, Geelong, Nedlands

2024-02-08

Active, closed

Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)

NCT06225596Metastatic Urothelial Cancer

DrugsZelenectide pevedotin·Avelumab·Gemcitabine·Cisplatin

BicycleTx Limited

Phase 2

375

Adelaide, Brisbane, Douglas, Geelong, Hunter, Nedlands, New South Wales, South Brisbane

2024-01-24

Recruiting

AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.

NCT06137144Lymphoma, Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Peripheral T-cell Lymphoma (PTCL)

DrugsAZD3470·Pembrolizumab

AstraZeneca

Phase 1/2

161

Adelaide, Birtinya, Fitzroy, Nedlands, South Brisbane, Waratah

2024-01-23

Active, closed

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis

NCT06260163Colitis, Ulcerative

DrugsTremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

112

Nedlands, South Brisbane, Westmead

2024-01-19

Recruiting

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

NCT06162221Non-Small Cell Lung Cancer, NSCLC, KRAS, NRAS, HRAS-mutated NSCLC, KRAS G12C-mutated Solid Tumors, Lung Cancer, Lung Cancer Stage IV, Advanced Solid Tumor, Cancer

DrugsElironrasib·RMC-9805·Cetuximab·Pemetrexed

Revolution Medicines, Inc.

Phase 1/2

616

Camperdown, Liverpool, St Leonards, Clayton, Nedlands

2024-01-18

Recruiting

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

NCT06179160Solid Tumors

DrugsGEMNabP·INCB161734·INCA33890·Retifanlimab

Incyte Corporation

Phase 1

710

Camperdown, Darlinghurst, Melbourne, Nedlands

2024-01-04

Recruiting

Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

NCT06056830Prostate Cancer, Prostatic Neoplasms

Drug64Cu-SAR-bisPSMA

Clarity Pharmaceuticals Ltd

Phase 3

383

Sydney, Woolloongabba, Murdoch, Nedlands

2023-12-21

Active, closed

A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment Naïve Mantle Cell Lymphoma

NCT05951959Mantle Cell Lymphoma (MCL)

DrugsAcalabrutinib·Venetoclax·Rituximab

AstraZeneca

Phase 2

108

Heidelberg, Kogarah, Nedlands, Sydney

2023-12-13

Active, closed

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

NCT06077760Non-small Cell Lung Cancer

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

868

Melbourne, Nedlands

2023-12-06

Active, closed

A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer

NCT06139406Lymphoma, Non-Hodgkin

DrugsJNJ-75348780·JNJ-87801493·JNJ-80948543

Janssen Research & Development, LLC

Phase 1

Heidelberg, Melbourne, Nedlands, Randwick

2023-12-06

Recruiting

AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

NCT06106945Multiple Myeloma

DrugsElranatamab·Pomalidomide·Dexamethasone

AstraZeneca

Phase 1/2

226

Fitzroy, Melbourne, Nedlands, Wollongong

2023-12-05

Recruiting

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

NCT06103864Breast Cancer

DrugsDatopotamab deruxtecan·Durvalumab·Nab-paclitaxel·Gemcitabine

AstraZeneca

Phase 3

625

Camperdown, Darlinghurst, Heidelberg, Melbourne, Nedlands, Waratah

2023-11-23

By invitation

A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies

NCT06208878Hematologic Malignancy, Solid Malignancy

CRISPR Therapeutics AG

Observational

Camperdown, Melbourne, Nedlands, Richmond

2023-11-22

Active, closed

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

NCT06016738Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Exemestane·Anastrozole·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

510

Gosford, Westmead, Adelaide, Ballarat Central, Clayton, Shepparton, Nedlands

2023-11-16

Recruiting

A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral Activity of Maribavir for the Treatment of Cytomegalovirus (CMV) Infection in Children and Adolescents Who Have Received a Hematopoietic Stem Cell Transplant (HSCT) or a Solid Organ Transplant (SOT)

NCT05319353Cytomegalovirus (CMV)

DrugMaribavir

Takeda

Phase 3

Randwick, Woollangabba, Parkville, Nedlands

2023-11-13

Active, closed

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma

NCT06097728Unresectable Pleural Mesothelioma

DrugsVolrustomig·Yervoy·Paraplatin·Opdivo

AstraZeneca

Phase 3

863

Chermside, Clayton, Melbourne, Nedlands, Westmead

2023-11-09

Recruiting

Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

NCT05862012Relapsed/Refractory Multiple Myeloma

Ichnos Sciences SA

Phase 1

200

Concord, Benowa, Fitzroy, Melbourne, Nedlands

2023-11-01

Active, closed

A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

NCT05952037Waldenstrom Macroglobulinemia, Waldenstrom's Macroglobulinemia Recurrent, Waldenstrom's Macroglobulinemia Refractory

DrugsSonrotoclax·Zanubrutinib

BeOne Medicines

Phase 2

114

Concord, St Leonards, Woolloongabba, Bedford PK, Clayton, Fitzroy, Nedlands, Perth

2023-10-23

Active, closed

Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

NCT05743244Diabetes Mellitus, Type 1

DrugsCibinqo·Ritlecitinib·Abrocitinib

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Phase 2

Saint Leonards, South Brisbane, Adelaide, Melbourne, Parkville, Nedlands

2023-10-19

Recruiting

The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease

NCT05811364Aortoiliac Occlusive Disease, Peripheral Arterial Disease

W.L.Gore & Associates

Not applicable

244

Adelaide, Nedlands, Randwick

2023-10-17

Recruiting

A Phase 2 Trial of GlOfitamab anD pIrtobrutinib in Mantle Cell Lymphoma Patients With Prior BTK Inhibitor Exposure.

NCT05833763Mantle Cell Lymphoma, Mantle Cell Lymphoma Refractory

DrugsPirtobrutinib·Glofitamab·Tocilizumab·Obinutuzumab

Australasian Leukaemia and Lymphoma Group

Phase 2

Parkville, Nedlands

2023-10-12

Active, closed

A Phase III Trial Comparing Tisagenlecleucel to Standard of Care (SoC) in Adult Participants With r/r Follicular Lymphoma

NCT05888493Follicular Lymphoma (FL)

DrugTisagenlecleucel

Novartis Pharmaceuticals

Phase 3

109

Camperdown, Clayton, Melbourne, Nedlands

2023-10-02

Recruiting

A Study Investigating BGB-26808 Alone or in Combination With Tislelizumab in Participants With Advanced Solid Tumors

NCT05981703Advanced Solid Tumor, Solid Tumor

DrugTislelizumab

BeOne Medicines

Phase 1

337

Miranda, North Ryde, Kurralta Park, Nedlands

2023-09-21

Recruiting

IKS014 in Advanced Solid Tumors That Express HER2

NCT05872295Breast Cancer, Gastric Cancer, Gastroesophageal-junction Cancer

Iksuda Therapeutics Ltd.

Phase 1

165

Concord, Sydney, Westmead, Frankston, Melbourne, Nedlands

2023-09-14

Recruiting

Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)

NCT05722938Community-acquired Pneumonia

Biotest

Phase 3

590

Woolloongabba, Clayton, Footscray, Heidelberg, Saint Albans, Nedlands

2023-09-09

Active, closed

Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine

NCT05846230Bronchiectasis

DrugVerducatib

Boehringer Ingelheim

Phase 2

268

Macquarie Park, Westmead, Chermside, South Brisbane, Nedlands, Spearwood

2023-09-08

Active, closed

A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations

NCT06052267Asthma

Teva Branded Pharmaceutical Products R&D LLC

Phase 3

2,772

Box Hill, Clayton, Melbourne, Midland, Nedlands, North Adelaide, Parkville, South Brisbane

2023-08-30

By invitation

Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older

NCT05844449Cystic Fibrosis

DrugVNZ/TEZ/D-IVA

Vertex Pharmaceuticals Incorporated

Phase 3

174

Nedlands, North Adelaide, Parkville, South Brisbane

2023-08-11

Recruiting

Study of MT-302 in Adults With Advanced or Metastatic Epithelial Tumors

NCT05969041Epithelial Tumors, Malignant

Myeloid Therapeutics

Phase 1

Darlinghurst, Randwick, Westmead, Bedford Park, Malvern, Nedlands

2023-08-02

Recruiting

The Safety and Tolerability of LBS-007 in Patients With Relapsed or Resistant Acute Leukaemias

NCT05756322Relapsed or Resistant Acute Leukaemias

Lin BioScience, Inc

Phase 1/2

Wollongong, Benowa, Adelaide, Melbourne, Nedlands, Perth

2023-07-20

Active, closed

A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

NCT05933577Melanoma

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

1,089

Westmead, Wollstonecraft, Brisbane, Melbourne, Nedlands

2023-07-19

Recruiting

A Phase 1/2 Study of D3S-002 as Monotherapy or Combination Therapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations

NCT05886920Advanced Solid Tumors With MAPK Pathway Mutations

DrugD3S-001

D3 Bio (Wuxi) Co., Ltd

Phase 1/2

Blacktown, Macquarie Park, Bedford Park, Melbourne, Nedlands

2023-07-10

Recruiting

DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

NCT05785754Advanced or Metastatic Solid Tumors

DrugsDCSZ11·Tebentafusp·Doxorubicin·Pembrolizumab

DynamiCure Biotechnology

Phase 1

320

Randwick, Sydney, Buderim, Bedford Park, Woodville South, Clayton, Malvern, Nedlands

2023-06-28

Recruiting

A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments

NCT05714839Multiple Myeloma

DrugsBelantamab mafodotin·Pomalidomide·Dexamethasone

GlaxoSmithKline

Phase 1/2

123

Fitzroy, Nedlands

2023-06-14

Active, closed

Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy

NCT05583552Myelodysplastic Syndromes, Acute Myeloid Leukemia

DrugImetelstat sodium

GCP-Service International West GmbH

Phase 2

Adelaide, Brisbane, Nedlands

2023-06-05

Recruiting

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

NCT05303519Glioma, Astrocytoma, Grade IV, IDH1-mutant Glioma, Astrocytoma, IDH-Mutant, Grade 3

DrugSafusidenib

Nuvation Bio Inc.

Phase 3

365

Darlinghurst, Saint Leonards, Herston, Melbourne, Nedlands

2023-06-05

Recruiting

Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma

NCT05826535Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Large B-cell Lymphoma

DrugsRondecabtagene autoleucel·Fludarabine·Cyclophosphamide

Lyell Immunopharma, Inc.

Phase 1/2

270

Nedlands, Perth, Melbourne

2023-05-09

Active, closed

Study Evaluating SC291 in Subjects With r/r B-cell Malignancies (ARDENT)

NCT05878184Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia

DrugsSC291·Fludarabine·Cyclophosphamide

Sana Biotechnology

Phase 1

Adelaide, Melbourne, Nedlands

2023-05-02

Active, closed

A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL)

NCT05512390Diffuse Large B-Cell Lymphoma, Chronic Lymphocytic Leukemia, Follicular Lymphoma

DrugABBV-319

AbbVie

Phase 1

Concord, Fitzroy Melbourne, Nedlands

2023-04-26

Recruiting

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

NCT05774951Breast Cancer, Early Breast Cancer

DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole

AstraZeneca

Phase 3

4,300

Birtinya, Concord, Nedlands, Randwick, Tweed Heads, Waratah, Wendouree

2023-03-31

Active, closed

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05572515Relapsed or Refractory Multiple Myeloma

DrugsTeclistamab·Carfilzomib·Pomalidomide·Bortezomib

Janssen Research & Development, LLC

Phase 3

614

Blacktown, Fitzroy, Melbourne, Murdoch, Nedlands

2023-03-29

Active, closed

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

NCT05714202Bladder Cancer

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 3

1,135

Heidelberg, Macquarie University, Nedlands, South Brisbane

2023-03-23

Active, closed

Minimising Adverse Drug Reactions and Verifying Economic Legitimacy in Children (MARVEL-PIC)

NCT05667766Neoplasms, Bone Marrow Transplantation

Murdoch Childrens Research Institute

Not applicable

441

Randwick, North Adelaide, Parkville, Nedlands

2023-03-22

Active, closed

ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer

NCT05650879HER2 Mutant Non-small Cell Lung Cancer, HER2-positive Metastatic Breast Cancer, HER2 Gene Mutation, HER2 Amplification

DrugsELVN-002·Fam-Trastuzumab Deruxtecan-Nxki·Trastuzumab emtansine·Trastuzumab deruxtecan

Enliven Therapeutics

Phase 1

198

Westmead, Nedlands, Darlinghurst

2023-03-20

Active, closed

An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases

NCT05732402Lupus Nephritis, Immunoglobulin A Nephropathy, Membranous Nephropathy, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

DrugPovetacicept

Alpine Immune Sciences, Inc.

Phase 1/2

Concord, Saint Albans, Nedlands

2023-03-15

Recruiting

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

NCT05643742B-cell Lymphoma, Non-Hodgkin Lymphoma, B-cell Malignancy, Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

DrugZugo-cel

CRISPR Therapeutics AG

Phase 1/2

120

Camperdown, Melbourne, Nedlands

2023-03-10

Active, closed

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer

NCT05635708Non-small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer

DrugsGimistotug·Alcestobart·Nab-paclitaxel·Tislelizumab

BeiGene

Phase 2

400

Blacktown, Camperdown, Frenchs Forest, Port Macquarie, Nedlands, Subiaco

2023-03-07

Recruiting

First in Human Study of EMB-07 in Locally Advanced/Metastatic Solid Tumors or Relapse/Refractory Lymphoma

NCT05607498Advanced/Metastatic Solid Tumors, Relapse/Refractory Lymphoma

EpimAb Biotherapeutics (Suzhou)Co., Ltd.

Phase 1

150

Frankston, Nedlands

2023-03-01

Active, closed

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

NCT05566795Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma, Pediatric Low-grade Glioma

DrugTovorafenib

Day One Biopharmaceuticals, Inc.

Phase 3

418

South Brisbane, Nedlands, North Adelaide, Parkville, Randwick, Westmead

2023-02-27

Active, closed

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

NCT05676931Advanced Non-Small Cell Lung Cancer

DrugsQuemliclustat·Domvanalimab·Zimberelimab·Docetaxel

Gilead Sciences

Phase 2

400

Albury, Benowa, Adelaide, Nedlands

2023-02-21

Active, closed

Safety and Efficacy Study of Viaskin Peanut in Peanut-allergic Children 4-7 Years of Age

NCT05741476Allergy, Peanut

DBV Technologies

Phase 3

600

Adelaide, Nedlands, Parkville, Richmond, South Brisbane, Westmead

2023-02-21

Active, closed

A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy

NCT05621317Peanut Allergy, Peanut Hypersensitivity, Peanut-Induced Anaphylaxis, Immune System Diseases

Aravax Pty Ltd

Phase 2

Randwick, Westmead, South Brisbane, North Adelaide, Parkville, Nedlands

2023-02-09

Active, closed

A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

NCT05578976Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone

Genmab

Phase 3

900

Liverpool, Adelaide, Clayton, Heidelberg, Melbourne, Nedlands, Perth

2023-02-08

Recruiting

Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study

NCT05447559Surgical Site Infection

DrugCefazolin

Monash University

Phase 4

9,180

Sydney, Brisbane, Adelaide, Hobart, Melbourne, Nedlands, Perth

2023-02-07

Active, closed

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

NCT05686551Huntington Disease

Hoffmann-La Roche

Phase 2

301

Clayton, Parkville, Nedlands

2023-02-03

Active, closed

Study to Assess SLN124 in Patients With Polycythemia Vera

NCT05499013Polycythemia Vera

Silence Therapeutics plc

Phase 1/2

Benowa, Hobart, Kurralta Park, Melbourne, Nedlands, Richmond

2023-01-26

Recruiting

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

NCT05580562H3 K27M, Glioma

DrugDordaviprone

Jazz Pharmaceuticals

Phase 3

510

Randwick, Sydney, Herston, Hobart, Heidelberg, Nedlands

2023-01-23

Active, closed

Phase 2b Study of GSK4532990 in Adults With NASH

NCT05583344Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease

DrugGSK4532990

GlaxoSmithKline

Phase 2

284

Nedlands, Perth

2023-01-02

Recruiting

Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

NCT05650229Primary Mitochondrial Disease

DrugNapazimone

Pharming Technologies B.V.

Phase 2

180

Randwick, Saint Leonards, Parkville, Nedlands

2022-12-13

Active, closed

A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)

NCT05668988Non-small Cell Lung Cancer

DrugsSunvozertinib·Pemetrexed·Carboplatin

Dizal Pharmaceuticals

Phase 3

324

Concord, Melbourne, Nedlands, Randwick

2022-12-13

Active, closed

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

NCT05501886Breast Cancer

DrugsGedatolisib·Alpelisib·Palbociclib·Fulvestrant

Celcuity Inc

Phase 3

701

Adelaide, Fitzroy, Frankston, Nedlands, South Brisbane, Southport, Wahroonga, Woodville

2022-12-08

Active, closed

A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough

NCT05600777Cough, Refractory Chronic Cough

DrugCamlipixant

Bellus Health Inc. - a GSK company

Phase 3

997

Coffs Harbour, Macquarie University, New Lambton Heights, St Leonards, Chermside, Adelaide, St Albans, Nedlands

2022-12-05

Active, closed

Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations

NCT05544552Locally Advanced Urothelial Carcinoma, Metastatic Urothelial Carcinoma, Solid Tumor, Urothelial Carcinoma

DrugTYRA-300

Tyra Biosciences, Inc

Phase 1/2

310

Macquarie Park, Southport, Woolloongabba, Heidelberg, Melbourne, Nedlands

2022-11-22

Active, closed

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Observational

6,000

Hurstville, Westmead, Geebung, East Melbourne, Melbourne, Rowville, Broome, Nedlands

2022-11-21

Recruiting

A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma

NCT05533775Mature B-Cell Non-Hodgkin Lymphoma

DrugsIfosfamide·Glofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

South Brisbane, Nedlands

2022-11-16

Active, closed

A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy

NCT05444257Cystic Fibrosis

DrugVNZ/TEZ/D-IVA

Vertex Pharmaceuticals Incorporated

Phase 3

822

Camperdown, Chermside, Melbourne, Nedlands, Parkville, South Brisbane, Westmead

2022-11-08

Active, closed

A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)

NCT05170204Non-Small Cell Lung Cancer

DrugsEntrectinib·Alectinib·Durvalumab

Hoffmann-La Roche

Phase 3

Melbourne, Nedlands

2022-11-01

Recruiting

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

NCT05552222Multiple Myeloma

DrugsTalquetamab·Teclistamab·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,590

Camperdown, Geelong, Liverpool, Nedlands, New South Wales, Wollongong, Woolloongabba

2022-10-25

Active, closed

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

NCT05581004Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma

DrugsTecentriq·Atezolizumab·Keytruda·Pembrolizumab

Genentech, Inc.

Phase 1

165

Darlinghurst, Clayton, Nedlands

2022-10-20

Recruiting

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

NCT05183035Acute Myeloid Leukemia

DrugsGemtuzumab Ozogamicin·Cytarabine·Azacitidine·Fludarabine

PedAL BCU, LLC

Phase 3

130

South Brisbane, Parkville, Nedlands

2022-10-01

Active, closed

A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer

NCT05483868Non-muscle-invasive Bladder Cancer, NMIBC, Non-Muscle Invasive Bladder Carcinoma, Non-Muscle Invasive Bladder Neoplasms

DrugBel-sar

Aura Biosciences

Phase 1

Westmead, Heidelberg, Langwarrin, Parkville, Nedlands

2022-09-26

Recruiting

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT05519085Relapsed or Refractory Multiple Myeloma

DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib

Celgene

Phase 3

810

Liverpool, Waratah, Wollongong, Birtinya, Box Hill, Melbourne, Nedlands

2022-09-20

Active, closed

A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanoma

NCT05309421Melanoma Stage IV, Unresectable Melanoma

DrugsKeytruda·Pembrolizumab

Evaxion Biotech A/S

Phase 2

Wollstonecraft, Nedlands

2022-09-19

Recruiting

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

NCT05519449Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, Castration Resistant Prostatic Cancer

DrugsJANX007·Darolutamide

Janux Therapeutics

Phase 1

272

Camperdown, Bedford Park, Nedlands

2022-09-15

Recruiting

Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

NCT05465174Craniopharyngioma, Child, Craniopharyngioma, Recurrent Craniopharyngioma

DrugTovorafenib

Sabine Mueller, MD, PhD

Phase 2

New Lambton Heights, Hobart, Clayton, Parkville, Nedlands

2022-09-12

Active, closed

A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT05057494Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

DrugsAcalabrutinib·Obinutuzumab·Venetoclax

AstraZeneca

Phase 3

607

Clayton, Nedlands, Waratah

2022-09-12

Recruiting

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

NCT05533697Advanced Solid Tumors

DrugsIpilimumab·Nivolumab·Pembrolizumab

ModernaTX, Inc.

Phase 1/2

361

Miranda, Wollongong, Wollstonecraft, Melbourne, Nedlands

2022-09-01

Active, closed

Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

NCT05508906Metastatic Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Breast Cancer

DrugsPalazestrant·Atirmociclib·Alpelisib·Everolimus

Olema Pharmaceuticals, Inc.

Phase 1

190

Sydney, Nedlands

2022-08-31

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

NCT05271409Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

DrugSatralizumab

Hoffmann-La Roche

Phase 3

132

Camperdown, Clayton, Nedlands

2022-08-30

Active, closed

A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

NCT05424822Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

DrugJNJ-80948543

Janssen Research & Development, LLC

Phase 1

167

Macquarie University, Melbourne, Nedlands, Randwick

2022-08-18

Recruiting

International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery

NCT05673499Congenital Disorders, Cerebral Desaturation, Neonatal Surgery

Children's Hospital of Philadelphia

Observational

900

Nedlands, Parkville

2022-08-12

Active, closed

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

NCT05468697Renal Cell Carcinoma

DrugsBelzutifan·Palbociclib

Merck Sharp & Dohme LLC

Phase 1/2

Macquarie University, Westmead, Frankston, Nedlands

2022-08-10

Recruiting

Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

NCT05376267Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain

University of Michigan

Not applicable

900

Brisbane, Douglas, Southport, North Adelaide, Clayton, Parkville, Nedlands

2022-08-05

Recruiting

A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

NCT05410145KRAS P.G12C

DrugsD3S-001·Cetuximab·Pemetrexed·Cisplatin

D3 Bio (Wuxi) Co., Ltd

Phase 1/2

442

Sydney, Malvern, Melbourne, Nedlands, Bedford Park

2022-08-03

Recruiting

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma

DrugsPirtobrutinib·Ibrutinib

Loxo Oncology, Inc.

Phase 3

737

Nedlands, St Albans, West Perth

2022-07-22

Active, closed

Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

NCT05382299Triple Negative Breast Cancer, PD-L1 Negative

DrugsAbraxane·Sacituzumab Govitecan·Nab-paclitaxel·Gemcitabine

Gilead Sciences

Phase 3

623

Kogarah, South Brisbane, Woolloongabba, Adelaide, Clayton, Melbourne, Nedlands

2022-07-20

Recruiting

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

NCT05475925LGLL - Large Granular Lymphocytic Leukemia, Primary Cutaneous Gamma-Delta T-Cell Lymphoma, Primary Cutaneous CD8+ Aggressive Epidermotropic T-Cell Lymphoma, Hepatosplenic T-cell Lymphoma

DrugDibotatug

Dren Bio

Phase 1/2

200

Clayton, Richmond, Nedlands

2022-07-13

Active, closed

Natural History of PRPF31 Mutation-Associated Retinal Dystrophy

NCT05573984Retinitis Pigmentosa, Eye Diseases, Hereditary, Retinal Dystrophies, Retinal Dystrophy Rod

PYC Therapeutics

Observational

Nedlands, East Melbourne

2022-07-07

Recruiting

Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour

NCT05230758Medulloblastoma, Childhood, Cognitive Impairment

DrugGlucophage

Donald Mabbott

Phase 3

140

New Lambton Heights, Westmead, Adelaide, Clayton, Parkville, Nedlands

2022-07-01

Active, closed

Merit WRAPSODY™ Endoprosthesis for Treatment of Stenosis or Occlusion (WRAP)

NCT05062291Venous Stenosis, Venous Occlusion

Merit Medical Systems, Inc.

Observational

500

Clayton, Liverpool, Murdoch, Nedlands, Woolloongabba

2022-06-23

Active, closed

Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

NCT05422222Cystic Fibrosis

DrugVNZ/TEZ/D-IVA

Vertex Pharmaceuticals Incorporated

Phase 3

210

Nedlands, North Adelaide, Parkville, South Brisbane

2022-06-21

Recruiting

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

NCT05320198Myelofibrosis; Anemia, Anemia, Myelofibrosis, Myelofibrosis Due to and Following Polycythemia Vera

DrugDISC-0974

Disc Medicine, Inc

Phase 1/2

150

Nedlands, Saint Albans, Sydney, West Perth

2022-06-06

Recruiting

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

NCT05076175Colitis, Ulcerative

DrugOzanimod

Bristol-Myers Squibb

Phase 2/3

120

Westmead, Clayton, Murdoch, Nedlands

2022-05-30

Active, closed

An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration

NCT05300724Age-Related Macular Degeneration

Genentech, Inc.

Observational

400

Parramatta, Sydney, Adelaide, East Melbourne, Nedlands

2022-05-27

Active, closed

Adjuvant Encorafenib and Binimetinib in High-risk Stage II Melanoma With a BRAF Mutation.

NCT05270044Melanoma

Pierre Fabre Medicament

Phase 3

815

Sydney, Wollstonecraft, Woolloongabba, North Adelaide, Box Hill, Heidelberg, Prahran, Nedlands

2022-05-02

Recruiting

Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

NCT05219617Seizures, Lennox Gastaut Syndrome

SK Life Science, Inc.

Phase 3

252

Heidelberg, Melbourne, Nedlands, South Brisbane

2022-04-28

Recruiting

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

NCT05208047Advanced Gastrointestinal Stromal Tumors, Metastatic Cancer

DrugsBezuclastinib·Sunitinib·Midazolam

Cogent Biosciences, Inc.

Phase 3

482

Nedlands, Bankstown

2022-04-14

Active, closed

A Phase 3 Study of Rusfertide in Patients With Polycythemia Vera

NCT05210790Polycythemia Vera

DrugRusfertide

Protagonist Therapeutics, Inc.

Phase 3

293

Nedlands, Adelaide, Melbourne

2022-04-01

Active, closed

First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors

NCT05277051Neoplasms

DrugsRemzistotug·GSK5764227·Nelistotug·Belrestotug

GlaxoSmithKline

Phase 1

152

Nedlands

2022-03-22

Recruiting

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

NCT05315700Solid Tumors

ORIC Pharmaceuticals

Phase 1/2

350

Camperdown, Melbourne, Nedlands, Sydney

2022-03-10

Recruiting

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

NCT05128825High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

DrugAzenosertib

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 2

310

Chermside, South Brisbane, Adelaide, Toorak Gardens, East Melbourne, Nedlands, Subiaco

2022-02-17

Recruiting

Study to Evaluate IMP9064 as a Monotherapy or in Combination in Patients With Advanced Solid Tumors

NCT05269316Solid Tumor, Advanced Solid Tumor

Impact Therapeutics, Inc.

Phase 1/2

Blacktown, Nedlands

2022-02-11

Active, closed

LIFE-BTK PK Sub-study

NCT05208905Critical Limb Ischemia (CLI)

Abbott Medical Devices

Not applicable

Nedlands

2022-02-10

Active, closed

Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer

NCT04905069Prostate Cancer

Boston Scientific Corporation

Not applicable

500

Waratah, Woolloongabba, Nedlands

2021-12-21

Active, closed

A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients

NCT05266105Breast Cancer

DrugsPalazestrant·Palbociclib

Olema Pharmaceuticals, Inc.

Phase 1

Waratah, Westmead, South Brisbane, Southport, Clayton, Frankston, Geelong, Nedlands

2021-12-10

Recruiting

A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study

NCT06290505Esophageal Cancer

DrugDurvalumab

Australasian Gastro-Intestinal Trials Group

Phase 2

Garran, Albury, Newcastle, Herston, Bedford Park, Fitzroy, Melbourne, Nedlands

2021-12-08

Active, closed

A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

NCT05117476Advanced Solid Tumor, NSCLC

DrugsCLN-619·Carboplatin (AUC 6)·Datopotamab deruxtecan·Pemetrexed

Cullinan Therapeutics Inc.

Phase 1

440

Clayton, Melbourne, Nedlands

2021-10-29

Active, closed

ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03)

NCT04829604HER2 Positive Metastatic Breast Cancer

DrugARX788

Ambrx, Inc.

Phase 2

Frankston, Geelong, Nedlands

2021-10-26

Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

NCT05009992Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Diffuse Midline Glioma, H3 K27M-Mutant

DrugsDNX-2401·Dordaviprone·Paxalisib

University of California, San Francisco

Phase 2

360

New Lambton Heights, Westmead, South Brisbane, Clayton, Melbourne, Nedlands, Adelaide, Sydney

2021-10-20

Active, closed

Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain

NCT04809376Osteoarthritis, Knee

DrugPentosan Polysulfate Sodium

Paradigm Biopharmaceuticals USA (INC)

Phase 2/3

602

Maroubra, Southport, Stepney, Nedlands

2021-10-19

Recruiting

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

NCT05123482Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer, Endometrial Cancer

DrugsPalacaparib·Saruparib·Rilvegostomig

AstraZeneca

Phase 1/2

460

Clayton, Melbourne, Nedlands

2021-10-18

Recruiting

A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies

NCT05006716B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma

DrugTacabrutideg

BeOne Medicines

Phase 1/2

645

Concord, Waratah, Woolloongabba, Fitzroy, Heidelberg, Melbourne, Nedlands, West Perth

2021-09-13

Active, closed

A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma

NCT04974398Nasopharyngeal Carcinoma

DrugPenpulimab

Akeso

Phase 3

296

Camperdown, Darlinghurst, St Leonards, Heidelberg, Nedlands

2021-08-16

Active, closed

Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma

NCT04674683Unresectable or Metastatic Melanoma, Progressive Brain Metastasis

DrugsChidamide·Nivolumab

HUYABIO International, LLC.

Phase 3

450

Wahroonga, Buderim, South Brisbane, Ballarat, Shepparton, Brisbane, Liverpool, Nedlands

2021-08-12

Active, closed

Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)

NCT04956640Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Endometrial Neoplasms, Ovarian Neoplasms

DrugsOlomorasib·Erbitux·Cetuximab·Pemetrexed

Eli Lilly and Company

Phase 1/2

540

St Leonards, Sydney, Adelaide, Frankston, Nedlands

2021-07-19

Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

NCT04613921Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications

European Foundation for Study of Chronic Liver Failure

Observational

3,000

Heidelberg, Nedlands, Sydney

2021-07-08

Recruiting

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

NCT04802759Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

DrugsPh Fdc·Samuraciclib·Phesgo·Ipatasertib

Hoffmann-La Roche

Phase 1/2

316

Bedford Park, Frankston, Melbourne, Nedlands

2021-06-22

Active, closed

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

NCT04895358Breast Neoplasms

DrugsLiposomal doxorubicin·Xeloda·Abraxane·Taxol

Merck Sharp & Dohme LLC

Phase 3

342

Macquarie Park, Westmead, Frankston, Nedlands

2021-06-18

Recruiting

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

NCT04895709Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer

DrugsImzokitug·Pumitamig·Docetaxel·Nivolumab

Bristol-Myers Squibb

Phase 1/2

1,109

Blacktown, Liverpool, Brisbane, Malvern, Melbourne, Nedlands

2021-05-27

Active, closed

A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.

NCT04835805Melanoma

DrugsBelvarafenib·Cobimetinib·Nivolumab

Genentech, Inc.

Phase 1

Waratah, Melbourne, Nedlands

2021-05-13

Active, closed

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Ribociclib·Abemaciclib·Palbociclib

AstraZeneca

Phase 3

893

Darlinghurst, Nedlands, Waratah

2021-05-10

Active, closed

Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)

NCT04675333Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma

DrugsEvorpacept·Cisplatin/Carboplatin·Fluorouracil·Keytruda

ALX Oncology Inc.

Phase 2

172

Herston, Adelaide, Melbourne, Nedlands

2021-05-10

Recruiting

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

NCT04614103Metastatic Non Small Cell Lung Cancer

Iovance Biotherapeutics, Inc.

Phase 2

170

Darlinghurst, Westmead, Nedlands

2021-05-07

Active, closed

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis

DrugsPelabresib·Ruxolitinib

Novartis Pharmaceuticals

Phase 3

430

Brisbane, Adelaide, Clayton, Frankston, Buderim, Nedlands

2021-04-09

Active, closed

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

NCT04662255Lymphoma, Mantle-Cell

DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib

Loxo Oncology, Inc.

Phase 3

500

Kogarah, Hobart, Nedlands, Perth, Auchenflower

2021-04-08

Recruiting

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia

DrugNemtabrutinib

Merck Sharp & Dohme LLC

Phase 2

490

Sydney, Box Hill, Nedlands

2021-04-05

Recruiting

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

NCT04665206Solid Tumor, Adult, Mesothelioma, NSCLC

DrugsPemetrexed/Carboplatin·Osimertinib·Ipilimumab

Vivace Therapeutics, Inc

Phase 1/2

434

Clayton, Melbourne, Nedlands

2021-03-24

Active, closed

A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)

NCT04817007Myelofibrosis

DrugsBMS-986158·Fedratinib·Ruxolitinib

Bristol-Myers Squibb

Phase 1/2

216

Blacktown, Wollongong, East Melbourne, Heidelberg, Nedlands, West Perth

2021-03-22

Active, closed

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

NCT04562389Myelofibrosis

DrugsSelinexor·Ruxolitinib

Karyopharm Therapeutics Inc

Phase 3

353

Bankstown, Campbelltown, Liverpool, South Brisbane, Adelaide, Nedlands

2021-03-11

Recruiting

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Durvalumab

AstraZeneca

Phase 1

304

Adelaide, Heidelberg, Nedlands

2021-03-09

Active, closed

An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis

DrugLuspatercept

Celgene

Phase 3

313

Clayton, Melbourne, Nedlands, Gosford, Hobart

2021-02-25

Active, closed

A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

NCT04408638Diffuse Large B-cell Lymphoma

DrugsRituxumab·Glofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 3

270

Randwick, Adelaide, Clayton, Fitzroy, Melbourne, Nedlands

2021-02-23

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors

NCT04431726Severe Hemophilia A

DrugEmicizumab

Hoffmann-La Roche

Phase 3

Westmead, Parkville, Nedlands

2021-02-04

Active, closed

A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL

NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia

DrugBlinatumomab

Amgen

Phase 1/2

181

Randwick, Westmead, South Brisbane, Adelaide, Clayton, Heidelberg, Melbourne, Nedlands

2021-01-04

Recruiting

Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities

NCT04683250RET-altered Non Small Cell Lung Cancer, RET-altered Solid Tumors

Taiho Pharmaceutical Co., Ltd.

Phase 1/2

244

Malvern, Nedlands, Saint Leonards

2020-12-16

Active, closed

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

NCT04622319HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer

DrugsTrastuzumab emtansine·Trastuzumab deruxtecan

Daiichi Sankyo

Phase 3

1,600

Adelaide, Camperdown, Clayton, Heidelberg, Melbourne, Nedlands, Saint Leonards, Subiaco

2020-12-04

Active, closed

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

NCT04603001Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), Myeloproliferative Neoplasms (MPNs)

DrugsLY3410738·Azacitidine·Venetoclax

Eli Lilly and Company

Phase 1

260

Melbourne, Nedlands

2020-11-19

Active, closed

Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy

NCT04281485Duchenne Muscular Dystrophy

Pfizer

Phase 3

114

Westmead, Parkville, Nedlands

2020-11-05

Active, closed

Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)

NCT04663347Diffuse Large B-Cell Lymphoma, Follicular Lymphoma

DrugsR-Ice·Rituximab and lenalidomide·Gemcitabine and oxaliplatin·Epcoritamab

Genmab

Phase 1/2

543

Heidelberg, Nedlands

2020-11-03

Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor

DrugsRezatapopt·Keytruda·Pembrolizumab

PMV Pharmaceuticals, Inc

Phase 1/2

300

Camperdown, South Brisbane, Bedford Park, Clayton, Nedlands

2020-10-29

Recruiting

A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer

NCT04516447Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer

DrugsAzenosertib·Pegylated liposomal doxorubicin·Gemcitabine·Paclitaxel

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 1

172

South Brisbane, Sunshine Coast, Adelaide, Melbourne, Nedlands

2020-10-26

Recruiting

Abbott Vascular Medical Device Registry

NCT04573660Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism

Abbott Medical Devices

Observational

3,784

Nedlands

2020-10-25

Active, closed

Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)

NCT03868618Obstructive Sleep Apnea

Nyxoah S.A.

Not applicable

115

Wollongong, Heidelberg, Nedlands

2020-10-14

Active, closed

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

NCT04538664Carcinoma, Non-Small-Cell Lung

DrugsAmivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 3

308

Camperdown, Kogarah, Malvern, Nedlands

2020-10-13

Active, closed

A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)

NCT04529772Diffuse Large B-Cell Lymphoma

DrugsAcalabrutinib·Vincristine·Doxorubicin·Prednisone

Acerta Pharma BV

Phase 3

611

Camperdown, Darlinghurst, Heidelberg, Hobart, Kogarah, Nedlands, Westmead

2020-10-08

Active, closed

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04487080Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Osimertinib

Janssen Research & Development, LLC

Phase 3

1,074

Bedford Park, Heidelberg, Malvern, Murdoch, Nedlands, Westmead, Wollongong, Woolloongabba

2020-09-30

Active, closed

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

NCT04404283Diffuse Large B-cell Lymphoma

DrugsBrentuximab Vedotin·Lenalidomide·Rituximab

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

239

Gosford, Hamlyn Terrace, Hobart, Nedlands, Adelaide, Eastwood, St Leonards

2020-08-20

Active, closed

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

NCT04482309Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer, Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 2

477

Auchenflower, Blacktown, Camperdown, Heidelberg, Melbourne, Nedlands

2020-08-18

Active, closed

LIFE-BTK Randomized Controlled Trial

NCT04227899Critical Limb Ischemia (CLI)

Abbott Medical Devices

Not applicable

261

Randwick, Nedlands

2020-08-18

Active, closed

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

NCT04449874Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors

DrugsDivarasib·Erlotinib·Inavolisib·Cetuximab

Genentech, Inc.

Phase 1

498

Mount Kuring-Gai, Melbourne, Nedlands

2020-07-29

Active, closed

AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

NCT04468659Preclinical Alzheimer's Disease, Early Preclinical Alzheimer's Disease

DrugLecanemab

Eisai Inc.

Phase 3

1,400

Darlinghurst, Waratah, Westmead, Adelaide, Ivanhoe, Nedlands

2020-07-14

Active, closed

Evaluation of Safety and Effectiveness of Stryker Surpass Evolve™ Flow Diverter System

NCT04195568Aneurysm, Intracranial

Stryker Neurovascular

Not applicable

248

Liverpool, Nedlands, Southport

2020-07-07

Active, closed

Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

NCT04270409Plasma Cell Myeloma

DrugsMontelukast·Diphenhydramine·Acetaminophen·Isatuximab

Sanofi

Phase 3

337

Liverpool, Waratah, Wollongong, Fitzroy, Heidelberg West, Richmond, Nedlands

2020-06-16

Active, closed

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma

DrugTazemetostat

Epizyme, Inc.

Phase 3

599

Adelaide, Bedford Park, Clayton, Geelong, Nedlands, Frankston, Hobart, Southport

2020-06-11

Recruiting

INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies

NCT03838042CNS Tumor, Solid Tumor

DrugOpdivo

University Hospital Heidelberg

Phase 1/2

Randwick, Westmead, Parkville, Nedlands

2020-05-26

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)

NCT04241185Urinary Bladder Neoplasms

DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda

Merck Sharp & Dohme LLC

Phase 3

520

Liverpool, St Leonards, Clayton, Heidelberg, Nedlands

2020-05-19

Active, closed

Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

NCT04269200Endometrial Neoplasms

DrugsOlaparib·Durvalumab·Paclitaxel·Carboplatin

AstraZeneca

Phase 3

805

Clayton, Malvern, Melbourne, Nedlands, Sydney

2020-05-05

Active, closed

Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection

NCT05110911Influenza, Human, SARS-CoV-2 Infection

DrugVaxzevria

University of Melbourne

Observational

1,500

New Lambton Heights, Westmead, Brisbane, Adelaide, Melbourne, Nedlands

2020-04-02

Recruiting

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

NCT04094610Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors

DrugRepotrectinib

Turning Point Therapeutics, Inc.

Phase 1/2

Randwick, Westmead, South Brisbane, Nedlands

2020-03-12

Active, closed

Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

NCT04262466Select Advanced Solid Tumors

DrugBrenetafusp

Immunocore Ltd

Phase 1/2

410

Randwick, Wollstonecraft, Melbourne, Nedlands

2020-02-25

Recruiting

Feasibility of the InnoVein Valve and Delivery System for Chronic Venous Insufficiency

NCT04253301Chronic Venous Insufficiency

InnoVein

Not applicable

Nedlands, Adelaide

2020-01-15

Active, closed

A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer

NCT04188548Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, Endometrial Cancer

DrugsImlunestrant·Alpelisib·Everolimus·Abemaciclib

Eli Lilly and Company

Phase 1

379

Darlinghurst, Waratah, Adelaide, Nedlands

2019-12-10

Recruiting

A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

NCT04065399Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia

DrugsCobicistat·Revumenib

Syndax Pharmaceuticals

Phase 1/2

447

Melbourne, Parkville, Nedlands, Saint Leonards

2019-11-05

Recruiting

High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

NCT04221035High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy

DrugsVindesine·Busulfan·Dacarbazine·Ifosfamide

Gustave Roussy, Cancer Campus, Grand Paris

Phase 3

800

Sydney, Clayton, Nedlands, New Lambton Heights, Westmead

2019-11-05

Active, closed

Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer

NCT04050436Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma

DrugsVusolimogene Oderparepvec·Cemiplimab

Replimune, Inc.

Phase 2

231

Camperdown, Wollongong, Southport, Clayton, Melbourne, Nedlands

2019-10-08

Active, closed

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

NCT03975647HER2-positive Breast Cancer

DrugsTucatinib·Trastuzumab emtansine

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

466

North Sydney, Westmead, Heidelberg, Melbourne, Parkville, Nedlands

2019-10-02

Active, closed

An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial

NCT03844048Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Multiple Myeloma, Non-Hodgkin's Lymphoma

DrugsVenclexta·Venetoclax

AbbVie

Phase 3

165

Camperdown, Kogarah, Liverpool, Melbourne, Murdoch, Nedlands

2019-09-06

Active, closed

Study of Lenalidomide, Venetoclax and Obinutuzumab in Patients With Treatment-Naïve Follicular Lymphoma

NCT03980171Follicular Lymphoma

DrugsVenclyxto·Venclexta·Obinutuzumab·Lenalidomide

Peter MacCallum Cancer Centre, Australia

Phase 1/2

Townsville, Melbourne, Nedlands

2019-08-19

Active, closed

Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

NCT03847428Hepatocellular Carcinoma

DrugsAvastin·Durvalumab·Bevacizumab

AstraZeneca

Phase 3

908

Kogarah, Melbourne, Nedlands, Westmead

2019-04-29

By invitation

Zoledronate In the Prevention of Paget's Disease: Long Term Extension

NCT03859895Paget Disease

University of Edinburgh

Observational

287

Geelong, Nedlands, Newcastle, Sydney, Toowoomba

2019-04-05

Active, closed

A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease

NCT03887455Early Alzheimer's Disease

DrugLecanemab

Eisai Inc.

Phase 3

1,906

Darlinghurst, Macquarie Park, Chermside Brisbane, Woodville South, Adelaid, Ivanhoe, Malvern, Nedlands

2019-03-27

Recruiting

Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

NCT03850574Leukemia, Myeloid, Acute, Refractory AML, Relapsed Adult AML, Myelodysplastic Syndrome With Excess Blasts-2

DrugsAzacitidine·Venetoclax

Aptose Biosciences Inc.

Phase 1/2

240

Albury, Herston, Townsville, Fitzroy, Nedlands

2019-03-11

Active, closed

Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

NCT03836261Chronic Lymphocytic Leukemia

DrugsVenclyxto·Acalabrutinib·Venclexta·Obinutuzumab

Acerta Pharma BV

Phase 3

984

Adelaide, Darlinghurst, Heidelberg, Kogarah, Melbourne, Nedlands, Waratah, Woolloongabba

2019-02-25

Active, closed

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

NCT03742895Advanced Solid Neoplasms

DrugOlaparib

Merck Sharp & Dohme LLC

Phase 2

329

Darlinghurst, Port Macquarie, Nedlands

2018-12-12

Active, closed

Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC

NCT03562637Triple Negative Breast Cancer

OBI Pharma, Inc

Phase 3

575

Westmead, Urraween, East Melbourne, Malvern, Nedlands, Darlinghurst, Gosford, Murdoch

2018-12-05

Active, closed

A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.

NCT03539744Multiple Myeloma

DrugsPomalidomide·Venetoclax·Dexamethasone

AbbVie

Phase 3

265

Liverpool, Wahroonga, Wollongong, Hyde Park, South Brisbane, Woodville South, Nedlands

2018-10-22

Active, closed

First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma

NCT03625037DLBCL, High-grade B-cell Lymphoma (HGBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), FL

DrugEpcoritamab

Genmab

Phase 1/2

666

Clayton, Concord, Fitzroy, Herston, Hobart, Kogarah, Malvern, Nedlands

2018-06-26

Active, closed

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

NCT03383458Hepatocellular Carcinoma, Liver Cancer

DrugsOpdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

545

Blacktown, Camperdown, Concord, Herston, Adelaide, Heidelberg, Nedlands

2018-04-18

Active, closed

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

NCT03466411Crohn's Disease

DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3·Ustekinumab

Janssen Research & Development, LLC

Phase 2/3

1,409

Adelaide, Clayton, Concord, Heidelberg, Nedlands, North Terrace, Parkville, Penrith

2018-04-13

Active, closed

A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib, Lenalidomide and Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant

NCT03319667Plasma Cell Myeloma

DrugsVelcade·Isatuximab·Bortezomib·Lenalidomide

Sanofi

Phase 3

475

Liverpool, Waratah, Wollongong, South Brisbane, Clayton, Heidelberg West, Nedlands, West Perth

2017-12-07

Active, closed

Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment

NCT02962414Tuberous Sclerosis Complex

DrugEverolimus

Novartis Pharmaceuticals

Phase 3

206

Sydney, Nedlands

2017-08-23

Active, closed

Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors

NCT03313778Solid Tumors

DrugsIntismeran autogene·Pembrolizumab

ModernaTX, Inc.

Phase 1

161

Darlinghurst, Westmead, Nedlands

2017-08-14

Active, closed

Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer

NCT02947685HER-2 Positive Breast Cancer, Estrogen Receptor Positive Breast Cancer

DrugsPerjeta·Herceptin·Exemestane·Anastrozole

Alliance Foundation Trials, LLC.

Phase 3

518

Clayton, Darlinghurst, Garran, Melbourne, Nedlands, South Brisbane, Waratah, Westmead

2017-06-21

Active, closed

A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy

NCT02993523Acute Myeloid Leukemia (AML)

DrugsAzacitidine·Venetoclax

AbbVie

Phase 3

443

Woolloongabba, Adelaide, Melbourne, Parkville, Nedlands, Perth

2017-02-02

By invitation

Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency

NCT02796937Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency

DrugAlpha-1 MP

Grifols Therapeutics LLC

Phase 3

290

Darlinghurst, Adelaide, Chermside, Fitzroy, Nedlands

2016-07

Recruiting

Quality of Pediatric Resuscitation in a Multicenter Collaborative

NCT02708134Cardiac Arrest, Cardiopulmonary Arrest

Children's Hospital of Philadelphia

Observational

7,000

Westmead, Nedlands, South Brisbane

2016-05-02

Active, closed

Study of Tumour Focused Radiotherapy for Bladder Cancer

NCT02447549Bladder Cancer

Institute of Cancer Research, United Kingdom

Phase 2

345

Wagga Wagga, Brisbane, Douglas, South Brisbane, Hobart, Melbourne, Nedlands

2015-10-21

Active, closed

Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)

NCT01983241Pulmonary Emphysema in Alpha-1 PI Deficiency

DrugAlpha-1 MP

Grifols Therapeutics LLC

Phase 3

345

Sydney, Chermside, Adelaide, Fitzroy, Nedlands

2013-11

Active, closed

Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer

NCT01872260Breast Cancer

DrugsAlpelisib·Ribociclib·Letrozole

Novartis Pharmaceuticals

Phase 1/2

259

Westmead, Parkville, Nedlands

2013-10-22

Active, closed

Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma

NCT01843374Unresectable Pleural or Peritoneal Malignant Mesothelioma

DrugTremelimumab

MedImmune LLC

Phase 2

571

Adelaide, Auchenflower, Box Hill, Chermside, East Bentleigh, Gosford, Heidelberg, Nedlands

2013-05-17

Active, closed

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

NCT01760005Alzheimers Disease, Dementia, Alzheimers Disease, Familial

DrugsE2814·Lecanemab

Washington University School of Medicine

Phase 2/3

490

Randwick, Melbourne, Nedlands

2012-12

Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Australian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 30 September 2026. https://priyalifescience.com/clinical-trials-australia/city/nedlands

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Clinical Trials in Nedlands, 2026

Trials with a site in Nedlands

About this register

How many clinical trials are recruiting in Nedlands?

Summary by phase

Most active sponsors

Phase	Studies	Recruiting	Share
Phase 3	137	61	36.9%
Phase 1	67	40	18.1%
Phase 1/2	66	51	17.8%
Phase 2	62	34	16.7%
Observational	14	5	3.8%
Not applicable	10	4	2.7%
Phase 2/3	10	4	2.7%
Phase EARLY_PHASE1	3	3	0.8%
Phase 4	2	1	0.5%