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Compound · clinical trials

Phesgo clinical trials

Also listed in trial records as Hyaluronidase-zzxf, RHuPH20, RO7198574, RG6264, Ph Fdc, Hyqvia, Hyaluronidase-zzxf/Pertuzumab/Trastuzumab, Pertuzumab/Trastuzumab/Hyaluronidase-zzxf
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 15 trials in our USA, Spain, Germany, Italy, France, Poland, Brazil, South Korea, UK, Belgium, Mexico, Australia, India, China, Turkey, Taiwan, Canada, Japan, Israel, Sweden, Czechia, Portugal, Egypt, Singapore, Switzerland, Austria, Norway and Denmark registers that name Phesgo as an intervention. Synced 1 Oct 2026
15Current trials
8Recruiting now
10Lead sponsors
28Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Phesgo is named as an intervention in 15 current clinical trials in our USA, Spain, Germany, Italy, France, Poland, Brazil, South Korea, UK, Belgium, Mexico, Australia, India, China, Turkey, Taiwan, Canada, Japan, Israel, Sweden, Czechia, Portugal, Egypt, Singapore, Switzerland, Austria, Norway and Denmark registers. 8 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Hoffmann-La Roche (3). The most-studied condition is HER2-positive Breast Cancer. The EU clinical trials register (CTIS) separately lists 1 authorised or ongoing trial.

Trials by status

  • Recruiting853%
  • Active, closed747%

Trials by phase

  • Phase 2747%
  • Phase 3533%
  • Phase 1213%
  • Phase 1/217%
01

Clinical trials of Phesgo

15 trials
StudyPhaseStatusLead sponsorRegisters
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
NCT05256225 · ClinicalTrials.gov ↗ · Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma
Phase 3 Recruiting National Cancer Institute (NCI) Mexico, South Korea
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
NCT05894239 · ClinicalTrials.gov ↗ · Metastatic Breast Cancer
Phase 3 Recruiting Hoffmann-La Roche UK, USA, India, China, Germany, France, Spain, Italy, Belgium, Poland, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore, Australia
A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
NCT06747351 · ClinicalTrials.gov ↗ · Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Phase 3 Recruiting Takeda USA, Germany, Spain, Italy, Sweden, Denmark, Poland, Czechia, Japan
Neoadjuvant Endocrine Therapy +/- the PI3K Inhibitor Inavolisib in HER2+, HR+, PIK3CA Mutant Early Breast Cancer
NCT05306041 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
Phase 2 Recruiting GBG Forschungs GmbH Germany, Spain, Italy, Poland
Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)
NCT05332561 · ClinicalTrials.gov ↗ · Early-stage Breast Cancer
Phase 2 Recruiting German Cancer Research Center Germany
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer
NCT04802759 · Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
Phase 1/2 Recruiting Hoffmann-La Roche USA, Spain, South Korea, Australia, Israel
A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants
NCT05418868 · ClinicalTrials.gov ↗ · HIV Infections
Phase 1 Recruiting ViiV Healthcare USA
First Time in Human Study of Long Acting VH4524184 Formulations
NCT06310551 · HIV Infections
Phase 1 Recruiting ViiV Healthcare USA
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
NCT05296798 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic Breast Cancer
Phase 3 Active, closed Hoffmann-La Roche UK, USA, India, China, Germany, France, Spain, Italy, Belgium, Poland, Portugal, Turkey, Brazil, Mexico, South Korea, Taiwan, Egypt
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
NCT05625399 · ClinicalTrials.gov ↗ · Melanoma
Phase 3 Active, closed Bristol-Myers Squibb UK, USA, Germany, France, Spain, Italy, Belgium, Sweden, Poland, Switzerland, Austria, Czechia, Norway, Canada, Brazil, Australia, Israel
Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer
NCT05041842 · ClinicalTrials.gov ↗ · Metastatic Breast Cancer With a Isolated Brain Progression
Phase 2 Active, closed UNICANCER France
A Study to Investigate the Virologic Efficacy and Safety of VH3810109 + Cabotegravir Compared to Standard of Care (SOC) in Male and Female Adults Living With Human Immunodeficiency Virus (HIV)
NCT05996471 · HIV Infections
Phase 2 Active, closed ViiV Healthcare USA
Classifying for HER2 Dependence to De-Escalate Neoadjuvant Chemotherapy in Patients With HER2+ Early Breast Cancer Undergoing HER2 Double-Blockade
NCT06068985 · ClinicalTrials.gov ↗ · Breast Cancer, HER2-positive Breast Cancer
Phase 2 Active, closed Latin American Cooperative Oncology Group Brazil
A Study to Evaluate Whether Participants With Melanoma Prefer Subcutaneous vs Intravenous Administration of Nivolumab and Nivolumab + Relatlimab Fixed-dose Combinations
NCT06101134 · ClinicalTrials.gov ↗ · Melanoma
Phase 2 Active, closed Bristol-Myers Squibb USA, Spain, Italy
PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer
NCT06172127 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
Phase 2 Active, closed MedSIR Germany, France, Spain, Italy

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Phesgo in the EU trials register (CTIS)

1 trial

Authorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Phesgo. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.

StudyPhaseStatusSponsorCountries
TAILOR-PANC: Molecularly Tailored Therapy versus Standard Care in Advanced Pancreatic Cancer (DPCG-02)
2025-522431-34-00 · CTIS ↗ · Neoplasms
Phase 2 Authorised Region Hovedstaden Denmark
03

Conditions studied with Phesgo

14 conditions
HER2-positive Breast Cancer3HIV Infections3Melanoma2Locally Advanced or Metastatic Breast Cancer1Metastatic Breast Cancer1Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer1Early-stage Breast Cancer1Metastatic Breast Cancer With a Isolated Brain Progression1Breast Cancer1Endometrial Carcinoma1Endometrial Clear Cell Adenocarcinoma1Endometrial Dedifferentiated Carcinoma1
All 14 conditions
Condition (as registered)Trials
HER2-positive Breast Cancer3
HIV Infections3
Melanoma2
Locally Advanced or Metastatic Breast Cancer1
Metastatic Breast Cancer1
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer1
Early-stage Breast Cancer1
Metastatic Breast Cancer With a Isolated Brain Progression1
Breast Cancer1
Endometrial Carcinoma1
Endometrial Clear Cell Adenocarcinoma1
Endometrial Dedifferentiated Carcinoma1
Endometrial Endometrioid Adenocarcinoma1
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Hoffmann-La Roche3
ViiV Healthcare3
Bristol-Myers Squibb2
MedSIR1
GBG Forschungs GmbH1
German Cancer Research Center1
UNICANCER1
Latin American Cooperative Oncology Group1
National Cancer Institute (NCI)1
Takeda1
05

By country register

RegisterTrialsRecruiting
Clinical trials in USA95
Clinical trials in Spain84
Clinical trials in Germany74
Clinical trials in Italy73
Clinical trials in France51
Clinical trials in Poland53
Clinical trials in Brazil41
Clinical trials in South Korea43
Clinical trials in UK31
Clinical trials in Belgium31
Clinical trials in Mexico32
Clinical trials in Australia32
Clinical trials in India21
Clinical trials in China21
Clinical trials in Turkey21
Clinical trials in Taiwan21
Clinical trials in Canada21
Clinical trials in Japan22
Clinical trials in Israel21
Clinical trials in Sweden21
Clinical trials in Czechia21
Clinical trials in Portugal10
Clinical trials in Egypt10
Clinical trials in Singapore11
Clinical trials in Switzerland10
Clinical trials in Austria10
Clinical trials in Norway10
Clinical trials in Denmark11
EU register (CTIS)1—

A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.

06

Related compounds

07

Questions about Phesgo trials

How many clinical trials are testing Phesgo?

15 current trials in our USA, Spain, Germany, Italy, France, Poland, Brazil, South Korea, UK, Belgium, Mexico, Australia, India, China, Turkey, Taiwan, Canada, Japan, Israel, Sweden, Czechia, Portugal, Egypt, Singapore, Switzerland, Austria, Norway and Denmark registers name Phesgo (also registered as RHuPH20) as a drug or biological intervention, as of the registry sync on 1 October 2026. Completed and withdrawn studies are not counted.

Are Phesgo trials recruiting patients?

Yes. 8 of the 15 trials are recruiting: 5 with sites in USA, 4 with sites in Spain, 4 with sites in Germany, 3 with sites in Italy, 1 with sites in France, 3 with sites in Poland, 1 with sites in Brazil, 3 with sites in South Korea, 1 with sites in UK, 1 with sites in Belgium, 2 with sites in Mexico, 2 with sites in Australia, 1 with sites in India, 1 with sites in China, 1 with sites in Turkey, 1 with sites in Taiwan, 1 with sites in Canada, 2 with sites in Japan, 1 with sites in Israel, 1 with sites in Sweden, 1 with sites in Czechia, 1 with sites in Singapore and 1 with sites in Denmark. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Phesgo clinical trials?

Hoffmann-La Roche (3), ViiV Healthcare (3), Bristol-Myers Squibb (2) and MedSIR (1), among 10 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Phesgo works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Phesgo works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Phesgo (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 1 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.