Real-world Study of Pyrotinib-containing Regimens of Advanced HER2-positive Breast Cancer
NCT07600164 · ClinicalTrials.gov ↗ · HER2 + Breast Cancer, Advanced Breast Cancer
|
Phase 4 |
Recruiting |
Peking University People's Hospital |
China |
|
A Study of SHR-A1811 in Subjects With Ovarian Cancer
|
Phase 3 |
Recruiting |
Jiangsu HengRui Medicine Co., Ltd. |
China |
A Clinical Trial of SHR-A1811 in the Treatment of Triple-negative Breast Cancer
NCT07111832 · ClinicalTrials.gov ↗ · PD-L1-positive Locally Recurrent Unresectable or Metastatic Triple-negative Breast Cancer
|
Phase 3 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
|
Artificial Intelligence Model-Guided Neoadjuvant Anti-HER2 Targeted Therapy
|
Phase 3 |
Recruiting |
Fudan University |
China |
A Study of Trastuzumab Rezetecan in Combination With Adebrelimab Versus Investigator's Choice of Therapy in Subjects With Residual Triple Negative Breast Cancer
NCT07679360 · ClinicalTrials.gov ↗ · Triple Negative Breast Cancer
|
Phase 3 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
Reverse Triple Negative Immune Resistant Breast Cancer
NCT05076682 · ClinicalTrials.gov ↗ · Triple-negative Breast Cancer
|
Phase 2 |
Recruiting |
Fudan University |
China |
Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy
NCT05582499 · ClinicalTrials.gov ↗ · Breast Neoplasm, Breast Cancer, Breast Tumors
|
Phase 2 |
Recruiting |
Fudan University |
China |
SNF Platform Study of HR+/ HER2-advanced Breast Cancer
NCT05594095 · ClinicalTrials.gov ↗ · Breast Neoplasm, Breast Cancer, Hormone Receptor Positive Tumor
|
Phase 2 |
Recruiting |
Fudan University |
China |
A Study of SHR-A1811 Monotherapy or Combined With Pyrotinib Maleate as Neoadjuvant Treatment in HER2-positive Breast Cancer Patients
NCT05635487 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 2 |
Recruiting |
Shengjing Hospital |
China |
SHR-A1811 Alone or in Combination With Adebrelimab as Neoadjuvant Treatment in HR Positive/HER2 Low Breast Cancer
NCT06340230 · ClinicalTrials.gov ↗ · HR Positive/HER2 Low Breast Cancer
|
Phase 2 |
Recruiting |
Shengjing Hospital |
China |
|
Exploratory Platform Research on Precision Therapy of Advanced Pancreatic Cancer
|
Phase 2 |
Recruiting |
Fudan University |
China |
Platform Study of ADC Rechallenge in ADC-treated Metastatic Breast Cancer
NCT06649331 · ClinicalTrials.gov ↗ · Advanced Breast Cancer, Metastatic Breast Cancer, Triple Negative Breast Cancer (TNBC)
|
Phase 2 |
Recruiting |
Fudan University |
China |
A Clinical Study of SHR-A1811 in the Treatment of HER2-positive Locally Advanced or Metastatic Biliary Tract Cancer
NCT06778031 · ClinicalTrials.gov ↗ · HER2-positive Locally Advanced or Metastatic Biliary Tract Cancer
|
Phase 2 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
A Phase II Trial of SHR-A1811 in HER2-Expressing Recurrent/Metastatic Cervical Cancer
NCT07051486 · ClinicalTrials.gov ↗ · Recurrent or Metastatic Cervical Cancer
|
Phase 2 |
Recruiting |
Jiangsu HengRui Medicine Co., Ltd. |
China |
Trastuzumab Rezetecan Combined With Radiotherapy Versus Trastuzumab Rezetecan in the Treatment of HER2-positive Advanced Breast Cancer With Brain Metastases
NCT07100600 · ClinicalTrials.gov ↗ · HER2-positive Advanced Breast Cancer, Brain Metastases, Radiotherapy
|
Phase 2 |
Recruiting |
Henan Cancer Hospital |
China |
Safety and Efficacy of SHR2554 Combined With Other Antitumor Therapies in Gastric or Gastro-oesophageal Junction Adenocarcinoma
NCT07102901 · ClinicalTrials.gov ↗ · Advanced Gastric Cancer, Metastatic Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
|
Phase 2 |
Recruiting |
Jiangsu HengRui Medicine Co., Ltd. |
China |
A Trial of Adebrelimab Plus (SHR-A1811/SHR-A1904 With Chemotherapy) or SHR-8068 as Treatment for Gastric/GEJ Cancer
NCT07110571 · ClinicalTrials.gov ↗ · Gastric Cancer, Gastroesophageal-junction Cancer
|
Phase 2 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
The Efficacy and Safety of Trastuzumab Rezetecan (SHR-A1811) in HER2-Low Unresectable/Metastatic Breast Cancer Patients With Visceral Crisis
NCT07203729 · ClinicalTrials.gov ↗ · HER2-Low Unresectable/Metastatic Breast Cancer Complicated With Visceral Crisis
|
Phase 2 |
Recruiting |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
China |
Phase II Study of Trastuzumab Rezetecan or in Combination With Adebrelimab in HER2-Expressing Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC)
NCT07241793 · ClinicalTrials.gov ↗ · Urothelial Carcinoma, Advanced Urothelial Carcinoma, Urothelial Carcinoma Recurrent
|
Phase 2 |
Recruiting |
Sun Yat-sen University |
China |
Trastuzumab Rezetecan in Advanced Solid Tumors Refractory to Standard Therapies
NCT07309770 · ClinicalTrials.gov ↗ · Urachal Cancer, Advanced Solid Tumor Cancer, Antibody-drug Conjugates
|
Phase 2 |
Recruiting |
Sheng Zhang |
China |
Neoadjuvant Trastuzumab-rezetecan Plus Pertuzumab or Nab-Paclitaxel, Carboplatin, Trastuzumab, and Pyrotinib After Suboptimal Response to Neoadjuvant Dual HER2-Targeted Therapy Combined With Chemotherapy in HER2-Positive Early Breast Cancer
NCT07340398 · ClinicalTrials.gov ↗ · HER2-positive Early Breast Cancer
|
Phase 2 |
Recruiting |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
China |
A Trial of Trastuzumab Rezetecan in Unresectable Locally Recurrent/Metastatic Breast Cancer
NCT07497386 · ClinicalTrials.gov ↗ · Unresectable Locally Recurrent Breast Cancer, Unresectable Locally Metastatic Breast Cancer
|
Phase 2 |
Recruiting |
Jiangsu HengRui Medicine Co., Ltd. |
China |
Trastuzumab Rezetecan Neoadjuvant Therapy in THP-Insensitive HER2-Positive Early Breast Cancer
NCT07647263 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 2 |
Recruiting |
The First Affiliated Hospital of Soochow University |
China |
Phase II Study of Trastuzumab Rezetecan Combined With Adebrelimab and Lenvatinib as First-Line Therapy for Advanced HER2-Positive/HER2-Low Biliary Tract Cancer
NCT07670273 · ClinicalTrials.gov ↗ · Biliary Tract Neoplasms Immunotherapy
|
Phase 2 |
Recruiting |
Peking Union Medical College Hospital |
China |
Phase II Study of Trastuzumab Rezetecan Combined With Adebrelimab and Lenvatinib in Advanced HER2-Positive/Low-Expression Biliary Tract Cancer
NCT07704177 · ClinicalTrials.gov ↗ · Biliary Tract Neoplasms Immunotherapy
|
Phase 2 |
Recruiting |
Peking Union Medical College Hospital |
China |
|
Neoadjuvant Gemcitabine Plus Trastuzumab Rezetecan in HER2-positive UTUC
|
Phase 2 |
Recruiting |
Zhiquan Hu |
China |
Phase II Study of SHR-A1811 for Ultra-Low HER2 Advanced Breast Cancer
NCT07817082 · ClinicalTrials.gov ↗ · Advanced Breast Cancer With Ultra-Low HER2 Expression
|
Phase 2 |
Recruiting |
Tianjin Medical University Cancer Institute and Hospital |
China |
|
Study of HRS-8080 or SHR-A2009 Combined With Anti-tumor Therapy in Patients With Unresectable or Metastatic Breast Cancer
|
Phase 1/2 |
Recruiting |
Shandong Suncadia Medicine Co., Ltd. |
China |
Study of SHR-A1811 Combined With Pyrotinib and Bevacizumab in Advanced Breast Cancer With Brain Metastasis
NCT06718933 · ClinicalTrials.gov ↗ · Breast Cancer Metastatic, Breast Cancer Brain Metastases
|
Phase 1/2 |
Recruiting |
Fudan University |
China |
|
A Clinical Study of SHR-A1811 Combined With Chemotherapy for Platinum Sensitive Recurrent Ovarian Cancer
|
Phase 1/2 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
SHR-A1811 Combination Regimen for the Treatment of Recurrent or Metastatic Cervical Cancer
NCT06859775 · ClinicalTrials.gov ↗ · Recurrent or Metastatic Cervical Cancer
|
Phase 1/2 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
|
A Study of HRS-4508 in Combination With Other Anti-tumor Therapy for Solid Tumor
|
Phase 1/2 |
Recruiting |
Jiangsu HengRui Medicine Co., Ltd. |
China |
|
A Clinical Study of SHR-A1811(sc) Subcutaneous Injection in Patients With Solid Tumor
|
Phase 1 |
Recruiting |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
|
SHR - A1811 Versus Chemotherapy for Platinum-resistant Recurrent Epithelial Ovarian Cancer
|
Phase 3 |
Not yet open |
Tongji Hospital |
China |
|
Famitinib Combined With SHR-A1811, Versus SHR-A1811 for CDK4/6 Inhibitors-resistent Advanced HR+/HER2- Breast Cancer With SNF4 Subtype
|
Phase 3 |
Not yet open |
Fudan University |
China |
Neoadjuvant SHR-A1811 Plus Adebrelimab in HR Negative/Low & HER2 Low Breast Cancer Patients
NCT06592625 · ClinicalTrials.gov ↗ · Untreated Early-stage or Locally Advanced Breast Cancer
|
Phase 2 |
Not yet open |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
|
SHR-1811 Combined With Carboplatin in the Treatment of Advanced Breast Cancer With HER2 Expression
|
Phase 2 |
Not yet open |
Anhui Provincial Cancer Hospital |
China |
Maintenance Therapy in HER2-Positive Unresectable Locally Recurrent or Metastatic Breast Cancer: A Phase II Study
NCT07179939 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 2 |
Not yet open |
Fudan University |
China |
Chemotherapy With or Without Adebrelimab and T-DXh as Neoadjuvant Therapy for HR+/HER2 Low Early Stage Breast Cancer
NCT07317778 · ClinicalTrials.gov ↗ · Breast Cancer Early Stage Breast Cancer (Stage 1-3), HR Positive/HER2 Low Breast Cancer
|
Phase 2 |
Not yet open |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
China |
Serplulimab Combined With Trastuzumab Rezetecan as Neoadjuvant Therapy for Triple-Negative Breast Cancer
NCT07466303 · ClinicalTrials.gov ↗ · Breast Cancer, Serplulimab Combined With SHR-A1811 as Neoadjuvant Therapy for Triple-Negative Breast Cancer
|
Phase 2 |
Not yet open |
Xijing Hospital |
China |
Study of Multi-mode Thermal Therapy Combined With Immunotherapy In Patients With HER2-negative Breast Cancer With Liver Metastases
NCT07466927 · ClinicalTrials.gov ↗ · HER2-negative Breast Cancer
|
Phase 2 |
Not yet open |
Fudan University |
China |
|
Neoadjuvant SHR-A1811 Combined With Pertuzumab in HER2-Positive Breast Cancer: An Exploratory Clinical Study.
|
Phase 2 |
Not yet open |
Hebei Medical University Fourth Hospital |
China |
Exploratory Study of SHR-A1811 Via Different Administration Routes in Patients
NCT07560475 · ClinicalTrials.gov ↗ · HER2positive, Advanced Breast Cancer, HER2 + Breast Cancer
|
Phase 2 |
Not yet open |
Tianjin Medical University Cancer Institute and Hospital |
China |
Trastuzumab Rezetecan(SHR-A1811) Combined With Ivonescimab (AK112) in Locally Advanced or Metastatic Non-small Cell Lung Cancer Harboring HER2 Gene Abnormalities
NCT07630077 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
|
Phase 2 |
Not yet open |
Sun Yat-sen University |
China |
Efficacy and Safety of Trastuzumab Rezetecan or Trastuzumab Deruxtecan in Advanced Breast Cancer
NCT07630103 · ClinicalTrials.gov ↗ · Advanced Breast Cancer
|
Phase 2 |
Not yet open |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
China |
Trastuzumab Rezetecan Followed by Pyrotinib, and Trastuzumab Combined With Capecitabine as First-line Treatment for Advanced HER2-positive Breast Cancer
NCT07766772 · ClinicalTrials.gov ↗ · HER2 + Breast Cancer, Advanced Breast Cancer
|
Phase 2 |
Not yet open |
Fujian Cancer Hospital |
China |
Trastuzumab Rezetecan and Carboplatin ยฑ Bevacizumab Versus Investigator's Choice Chemotherapy in Patients With Platinum-sensitive Recurrent Ovarian Cancer
NCT07776171 · ClinicalTrials.gov ↗ · Ovarian Cancer, Platinum Sensitive Ovarian Cancer (PSOC)
|
Phase 2 |
Not yet open |
Sun Yat-sen University |
China |
SHR-A1811 Monotherapy or Sequential THPy as Neoadjuvant Therapy for Stage II-III HER2-Positive Breast Cancer
NCT07787338 · ClinicalTrials.gov ↗ · HER2-positive Breast Cancer
|
Phase 2 |
Not yet open |
First Affiliated Hospital of Zhejiang University |
China |
Phase II Study of Trastuzumab Rezetecan Combined With Retlirafusp Alfa With or Without CAPOX as Perioperative Therapy for Resectable Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
NCT07802288 · ClinicalTrials.gov ↗ · Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma
|
Phase 2 |
Not yet open |
Tianjin Medical University Cancer Institute and Hospital |
China |
|
Trastuzumab Combined With Retlirafusp Alfa in Treating HER2๏ผHuman Epidermal Growth Factor Receptor 2๏ผ 2+/3+ Gastric/Gastroesophageal Junction Adenocarcinoma After First-line Systemic Therapy Failure
|
Phase 2 |
Not yet open |
Henan Cancer Hospital |
China |
|
SHR - A1811 Injection in the Treatment of Platinum-sensitive Recurrent Ovarian Cancer
|
Phase 1/2 |
Not yet open |
Tongji Hospital |
China |
A Trial of SHR-A1811versus Pyrotinib in Combination With Capecitabine in HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With Trastuzumab and Taxane
NCT05424835 · ClinicalTrials.gov ↗ · HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With Trastuzumab and Taxane
|
Phase 3 |
Active, closed |
Jiangsu HengRui Medicine Co., Ltd. |
China |
|
SHR-A1811 Versus Investigator's Chemotherapy in Recurrent/Metastatic Breast Cancer Clinical Trial
|
Phase 3 |
Active, closed |
Jiangsu HengRui Medicine Co., Ltd. |
China |
A Phase III, Active-Controlled Study of SHR-A1811 Versus Trastuzumab Emtansine (T-DM1) in HER2-Positive Primary Breast Cancer Participants With Residual Invasive Disease Following Neoadjuvant Therapy
NCT06126640 · ClinicalTrials.gov ↗ · HER2-Positive Primary Breast Cancer Participants With Residual Invasive Disease Following Neoadjuvant Therapy
|
Phase 3 |
Active, closed |
Jiangsu HengRui Medicine Co., Ltd. |
China |
Injection of SHR-A1811 Versus Physician Choiced Treatment in Patients With Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-fu, and Irinotecan
NCT06199973 · ClinicalTrials.gov ↗ · Advanced Colorectal Cancer
|
Phase 3 |
Active, closed |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
China |
A Trial of SHR-A1811 Compared to Other Antitumor Therapies as Neoadjuvant Treatments in Early-stage or Locally Advanced HER2-positive Breast Cancer
NCT07196774 · ClinicalTrials.gov ↗ · Early-stage or Locally Advanced HER2-positive Breast Cancer
|
Phase 3 |
Active, closed |
Jiangsu HengRui Medicine Co., Ltd. |
China |
A Phase II Study of Advanced Salivary Gland Carcinoma Based on Molecular Typing
NCT05924256 · ClinicalTrials.gov ↗ · Advanced Salivary Gland Carcinoma
|
Phase 2 |
Active, closed |
Fudan University |
China |
|
Different Targeted Antibody-drug Conjugates For HER2 Ultra-low or No Expression Advanced Breast Cancer๏ผGALAXY๏ผ
|
Phase 1/2 |
Active, closed |
Fudan University |
China |