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Trackers› Clinical trials› Kentucky
Clinical trial register · United States · industry-sponsored

Clinical Trials in Kentucky, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca42 Merck Sharp & Dohme LLC38 Eli Lilly and Company22 Janssen Research & Development, LLC20 AbbVie19
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Kentucky

771 of 9118 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study
NCT05409989Intracranial Aneurysm
Microvention-Terumo, Inc.
Not applicable
154
Florida, Hawaii, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts
2022-09-20
Recruiting
Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT05168566Non-small Cell Lung Cancer
DrugSutetinib Maleate
Teligene US
Phase 2
99
California, Georgia, Kentucky, Maryland, North Carolina, Texas
2022-09-01
Active, closed
Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With GEP-NETs and PPGLs
NCT04711135Gastroenteropancreatic Neuroendocrine Tumors, Pheochromocytoma, Paraganglioma
DrugsLutetium [177Lu] oxodotreotide/dotatate·Lutathera
Advanced Accelerator Applications
Phase 2
11
Kentucky, Ohio, Pennsylvania
2022-08-31
Active, closed
Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device
NCT04839705Wide Neck Bifurcation Intracranial Aneurysms
Microvention-Terumo, Inc.
Not applicable
195
Florida, Hawaii, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts
2022-08-24
By invitation
MDR ExploR Radial Head System PMCF
NCT05583448Elbow Injury
Zimmer Biomet
Observational
93
Kentucky
2022-08-16
Active, closed
A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma
NCT05249101Metastatic Pancreatic Adenocarcinoma
DrugsXeloda·Capecitabine
CG Pharmaceuticals, Inc
Phase 1/2
70
Arizona, California, Georgia, Indiana, Kentucky, Louisiana, Michigan, New York
2022-08-15
Active, closed
A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma
NCT05421663Lymphoma, Non-Hodgkin, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse
Janssen Research & Development, LLC
Phase 1/2
166
California, Colorado, Iowa, Kentucky, New Jersey, North Carolina, Ohio, Pennsylvania
2022-08-12
Active, closed
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
NCT05433584Type 2 Diabetes
DrugTirzepatide
Eli Lilly and Company
Phase 4
780
Alabama, California, Connecticut, Florida, Georgia, Indiana, Iowa, Kentucky
2022-08-01
Active, closed
Noninterventional Study Evaluating Parkinson's Disease Diary Use
NCT05363046Parkinson's Disease
BlueRock Therapeutics
Observational
194
Arizona, California, Colorado, Florida, Illinois, Kansas, Kentucky, Massachusetts
2022-07-29
Active, closed
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
NCT05458297Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
DrugsZilovertamab vedotin·Nemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
189
Alaska, Arizona, Colorado, Illinois, Kansas, Kentucky, Maryland, Massachusetts
2022-07-21
Active, closed
Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
NCT05382299Triple Negative Breast Cancer, PD-L1 Negative
DrugsAbraxane·Sacituzumab Govitecan·Nab-paclitaxel·Gemcitabine
Gilead Sciences
Phase 3
623
Arizona, California, Colorado, Florida, Georgia, Illinois, Iowa, Kentucky
2022-07-20
Recruiting
A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
NCT05361174Unresectable Melanoma, Metastatic Melanoma, Stage III Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Iovance Biotherapeutics, Inc.
Phase 1/2
53
California, Florida, Kansas, Kentucky, New York, Ohio, Pennsylvania, Wisconsin
2022-07-20
Recruiting
Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
NCT06426628Pulmonary Nodule, Solitary, Lung Cancer
Veracyte, Inc.
Observational
2,400
Connecticut, Florida, Illinois, Kansas, Kentucky, Louisiana, Maryland, Massachusetts
2022-07-18
Active, closed
A Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed ES-SCLC Patients in Combination With Carboplatin, Etoposide and Atezolizumab
NCT05142696Extensive Stage Small Cell Lung Cancer
Drugs[177Lu]Lu-DOTA-TATE·[68Ga]Ga-DOTA-TATE·Lutathera·Atezolizumab
Novartis Pharmaceuticals
Phase 1/2
55
Florida, Georgia, Kentucky, Missouri, New Jersey, Ohio, Pennsylvania
2022-07-13
Recruiting
A Study of RNK05047 in Subjects With Advanced Solid Tumors/Diffuse Large B-cell Lymphoma (CHAMP-1)
NCT05487170Advanced Solid Tumor, DLBCL
Ranok Therapeutics (Hangzhou) Co., Ltd.
Phase 1/2
32
Georgia, Kentucky, New York
2022-07-12
Recruiting
Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors
NCT05270213Advanced Cancer
DrugsRBS2418·Pembrolizumab
Riboscience, LLC.
Phase 1
164
Arizona, California, Delaware, Kentucky, Louisiana, Maryland, New York, North Carolina
2022-07-11
Active, closed
A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium
NCT05456425Pterygium
Cloudbreak Therapeutics, LLC
Phase 3
660
Alabama, Arizona, California, Florida, Kentucky, Nevada, South Dakota, Texas
2022-06-30
Active, closed
MOTUS Total Joint Replacement Investigational Device Exemption Study
NCT05438719Lumbar Spine Degeneration
3Spine
Not applicable
158
California, Colorado, Florida, Kentucky, Louisiana, Minnesota, New York, North Carolina
2022-06-23
Active, closed
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT04975997Multiple Myeloma
DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone
Celgene
Phase 3
939
Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2022-06-23
Recruiting
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
NCT05142189Non-Small Cell Lung Cancer
DrugsBNT116·Gotistobart·Cemiplimab·Osimertinib
BioNTech SE
Phase 1
320
Kentucky, Maryland, Ohio, Texas, Virginia
2022-06-17
Active, closed
Study to Evaluate the Safety and Efficacy of Pegvaliase in Adolescents (Ages 12-17) With Phenylketonuria
NCT05270837Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Phase 3
55
Arizona, Arkansas, Colorado, Florida, Illinois, Indiana, Kentucky, Massachusetts
2022-06-17
Active, closed
Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome
NCT05382156Endogenous Cushing's Syndrome
DrugOsilodrostat
RECORDATI GROUP
Observational
206
Arizona, Georgia, Illinois, Indiana, Kentucky, Massachusetts, Michigan, Minnesota
2022-06-13
Recruiting
Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
NCT05433142Clear Cell Renal Cell Carcinoma
Xencor, Inc.
Phase 1
307
Arizona, California, Connecticut, Florida, Georgia, Illinois, Kentucky, Minnesota
2022-06-13
Active, closed
A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancer
NCT05318573Advanced Urothelial Carcinoma, Advanced Non Small Cell Lung Cancer
DrugsFF-10832·Keytruda·Pembrolizumab
Fujifilm Pharmaceuticals U.S.A., Inc.
Phase 2
120
California, District of Columbia, Kansas, Kentucky, Michigan, Missouri, Nebraska, Nevada
2022-06-01
Recruiting
Acute Partial Thickness Burn Study Comparing Transforming Powder Dressing to Standard of Care Dressing
NCT05424354Wounds and Injuries
ULURU Inc.
Phase 4
60
California, District of Columbia, Florida, Kentucky, New York, Texas
2022-05-26
Active, closed
A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)
NCT05374512Breast Cancer
DrugsEribulin·Dato-DXd·Nab-paclitaxel·Capecitabine
AstraZeneca
Phase 3
644
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Kentucky, Michigan
2022-05-16
Active, closed
Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
NCT05069558Stroke, Patent Foramen Ovale, PFO
Occlutech International AB
Not applicable
450
Arizona, California, Colorado, District of Columbia, Illinois, Kentucky, Maine, Massachusetts
2022-05-09
Recruiting
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
Adela, Inc
Observational
7,000
California, Florida, Georgia, Indiana, Kentucky, Minnesota, Ohio, Oregon
2022-05-03
Recruiting
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
NCT05219617Seizures, Lennox Gastaut Syndrome
SK Life Science, Inc.
Phase 3
252
California, Florida, Idaho, Kentucky, Louisiana, Maryland, Minnesota, Missouri
2022-04-28
Active, closed
Evolut™ EXPAND TAVR II Pivotal Trial
NCT05149755Moderate Aortic Valve Stenosis
Medtronic Cardiovascular
Not applicable
650
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Kentucky
2022-04-27
Active, closed
US Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus
NCT05232838Hydrocephalus, Normal Pressure, Hydrocephalus
CereVasc Inc
Not applicable
50
Connecticut, Florida, Kansas, Kentucky, Massachusetts, New York, Rhode Island, Virginia
2022-04-20
Active, closed
A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)
NCT05288166Prostatic Neoplasms, Neoplasm Metastasis, Urogenital Neoplasms, Physiological Effects of Drugs
DrugsAbiraterone·Abemaciclib·Prednisolone·Prednisone
Eli Lilly and Company
Phase 3
925
Arizona, Arkansas, California, Colorado, Florida, Georgia, Indiana, Kentucky
2022-04-14
Active, closed
CONVERGE Post-Approval Study (PAS)
NCT05393180Chronic Atrial Fibrillation
AtriCure, Inc.
Not applicable
53
California, Connecticut, Florida, Georgia, Kentucky, Maryland, Massachusetts, New Jersey
2022-04-13
Active, closed
Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer
NCT05316155Non-Muscle Invasive Bladder Neoplasms
DrugErdafitinib
Janssen Research & Development, LLC
Phase 1/2
235
Alabama, California, Colorado, Florida, Illinois, Indiana, Kentucky, Louisiana
2022-04-11
Active, closed
CASCADE-LUNG: Cancer Screening Assay Using DELFI; A Clinical Validation Study in Lung
NCT05306288Lung Cancer
Delfi Diagnostics Inc.
Observational
11,935
Alabama, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2022-04-07
Active, closed
Long-term Follow-up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA)
NCT05232929Spinal Muscular Atrophy
DrugRisdiplam
Genentech, Inc.
Phase 4
403
Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Georgia, Kentucky
2022-03-29
Active, closed
Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy
NCT05477576GEP-NET, Gastroenteropancreatic Neuroendocrine Tumor, Gastroenteropancreatic Neuroendocrine Tumor Disease, Neuroendocrine Tumors
DrugsRYZ101·Octreotide·Lanreotide·Sunitinib
RayzeBio, Inc.
Phase 3
343
Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Iowa, Kentucky
2022-03-24
Recruiting
OssDsign® Spine Registry Study ("Propel")
NCT05329129Degenerative Disc Disease, Spinal Stenosis
OssDsign
Observational
450
California, Connecticut, Florida, Georgia, Illinois, Kentucky, Maryland, Minnesota
2022-03-23
By invitation
Long-Term Follow-up Study
NCT05332054Lymphoma, Non-Hodgkin, Relapsed Non-Hodgkin Lymphoma, Refractory B-Cell Non-Hodgkin Lymphoma, Non-Hodgkin Lymphoma
Caribou Biosciences, Inc.
Observational
150
Alabama, Arizona, California, Colorado, Florida, Georgia, Iowa, Kentucky
2022-03-16
Active, closed
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
NCT05100862Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma
DrugsRuxience·Truxima·Zanubrutinib·Obinutuzumab
BeOne Medicines
Phase 3
799
California, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky
2022-03-10
Active, closed
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
NCT05132582HER2 Positive Breast Cancer
DrugsPerjeta·Tucatinib·Herceptin·Pertuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
654
Arizona, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Maryland
2022-03-07
Active, closed
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
NCT05211895Non-Small Cell Lung Cancer
DrugsDomvanalimab·Durvalumab
AstraZeneca
Phase 3
791
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Maryland
2022-02-18
Active, closed
Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis
NCT05138133Lupus Nephritis
DrugAnifrolumab
AstraZeneca
Phase 3
363
Arizona, California, Florida, Georgia, Kentucky, New Jersey, New York, North Carolina
2022-02-15
Recruiting
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
NCT05263206Pruritus
DrugsFexofenadine·Dupilumab
Sanofi
Phase 3
284
California, District of Columbia, Florida, Georgia, Indiana, Kentucky, Louisiana, Maryland
2022-02-15
Active, closed
Long-term Follow-up Study of Allogeneic Gamma Delta (γδ) CAR T Cells
NCT04911478Lymphoma, Follicular, Lymphoma, Mantle-Cell, Marginal Zone Lymphoma, Primary Mediastinal B-cell Lymphoma
Adicet Therapeutics
Observational
50
California, Kentucky, Texas, Wisconsin
2022-02-14
Recruiting
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
NCT06378632Heart Failure
Cordio Medical
Observational
500
Alabama, California, Florida, Georgia, Illinois, Kansas, Kentucky, Louisiana
2022-02-11
Recruiting
Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma
NCT04879043Multiple Myeloma, Plasma Cell Disorder
DrugHDP-101
Heidelberg Pharma AG
Phase 1/2
78
Georgia, Kentucky, Nebraska, New York, Texas
2022-02-07
Active, closed
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
NCT05221840Non-Small Cell Lung Cancer
DrugsMonalizumab·Oleclumab·Durvalumab
AstraZeneca
Phase 3
1,051
California, Connecticut, Florida, Illinois, Indiana, Kentucky, Maryland, Michigan
2022-02-07
Active, closed
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
NCT05173987Endometrial Neoplasms
DrugsTaxotere·Paraplatin·Taxol·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
280
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2022-02-03
Active, closed
Safety and Immunogenicity of CRV-101 Vaccine for the Prevention of Herpes Zoster in Adults Aged 50 Years and Older
NCT05304351Herpes Zoster, Shingles
DrugShingrix
Curevo Inc
Phase 2
1,516
Arizona, Florida, Illinois, Kansas, Kentucky, Nevada, Oklahoma, Tennessee
2022-02-02
Recruiting
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
NCT05139017DLBCL, Diffuse Large B-Cell Lymphoma
DrugsZilovertamab vedotin·Granulocyte Colony-Stimulating Factor·Riabni·Ruxience
Merck Sharp & Dohme LLC
Phase 2/3
290
Arizona, California, Florida, Illinois, Kentucky, Maryland, Massachusetts, Michigan
2022-01-14
Active, closed
A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies
NCT05081609Advanced Solid Tumor, Locally Advanced Solid Tumor, Metastatic Solid Tumor, Platinum-resistant Ovarian Cancer
DrugsAdo-trastuzumab emtansine·Trastuzumab emtansine·Trastuzumab·Pembrolizumab
Ascendis Pharma Oncology Division A/S
Phase 1/2
320
California, Illinois, Kentucky, Massachusetts, New Jersey, New York, North Carolina, Ohio
2022-01-11
Active, closed
Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL)
NCT05218668Amyotrophic Lateral Sclerosis
DrugFasudil
Woolsey Pharmaceuticals
Phase 2
40
Arizona, Colorado, Florida, Illinois, Kentucky, Missouri, New York
2021-12-22
Active, closed
INSPIRE Pipeline™ Shield Post Approval Study
NCT05071963Intracranial Aneurysm
Medtronic Neurovascular Clinical Affairs
Observational
246
Alabama, Connecticut, Florida, Georgia, Illinois, Kentucky, Missouri, New York
2021-12-20
Active, closed
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
NCT05097287Asthma
DrugDupilumab
Sanofi
Phase 4
1,339
Alabama, Arizona, California, Florida, Georgia, Illinois, Kentucky, Louisiana
2021-12-16
Active, closed
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
NCT05116189Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
DrugsZirabev·Taxotere·Avastin·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
643
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2021-12-13
Active, closed
Prospective Case Collection Study for New Mammography Technologies
NCT05199701Mammography
Hologic, Inc.
Not applicable
7,500
Arizona, Florida, Kentucky, Maryland, Michigan, New York, North Carolina, Ohio
2021-12-10
Recruiting
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
NCT04892173Carcinoma, Squamous Cell
DrugsJNJ-90301900·Erbitux·Cetuximab
Johnson & Johnson Enterprise Innovation Inc.
Phase 3
500
Alabama, California, District of Columbia, Florida, Georgia, Kentucky, Massachusetts, New Mexico
2021-12-10
Recruiting
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
NCT05164172Migraine
DrugEptinezumab
H. Lundbeck A/S
Phase 3
600
Connecticut, Florida, Kentucky, Maryland, Michigan, New York, North Carolina, Ohio
2021-12-01
Recruiting
A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer
NCT05125016Metastatic Castration-resistant Prostate Cancer
DrugsNezastomig·REGN4336
Regeneron Pharmaceuticals
Phase 1/2
228
California, Connecticut, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio
2021-11-30
Recruiting
The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors
NCT05037825Non-Small-Cell Lung Carcinoma, Malignant Melanoma, Renal Cell Carcinoma, Triple-Negative Breast Cancer
VastBiome
Observational
800
Kentucky
2021-11-22
Active, closed
Safety, Tolerability, and Immunogenicity of MenABCWY Administered on Different Dosing Schedules in Healthy Adolescents
NCT05087056Meningitis, Meningococcal
GlaxoSmithKline
Phase 2
305
Alabama, Arizona, California, District of Columbia, Florida, Georgia, Indiana, Kentucky
2021-11-18
Recruiting
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
NCT05103683Advanced Solid Tumor, Ovarian Cancer, Endometrial Cancer, NSCLC
DrugTORL-1-23
TORL Biotherapeutics, LLC
Phase 1
90
California, Kentucky, Minnesota, New York, Ohio, Texas, Virginia
2021-11-17
Active, closed
A Study of NDI 1150-101 in Patients With Solid Tumors
NCT05128487Solid Tumor, Renal Cell Carcinoma (Kidney Cancer), Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma, Non-Small Cell Lung Cancer
DrugPembrolizumab
Nimbus Saturn, Inc.
Phase 1/2
106
Arizona, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Michigan, Minnesota
2021-11-05
Active, closed
Desara ® One Single Incision Sling 522 Study
NCT04772131Stress Urinary Incontinence
Caldera Medical, Inc.
Not applicable
300
Arizona, Florida, Idaho, Indiana, Kentucky, Massachusetts, Missouri, Nevada
2021-11-01
Recruiting
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
NCT05005403Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Micro Satellite Stable Colorectal Cancer, Gastric/Esophageal Cancer
DrugsBudigalimab·Telisotuzumab Adizutecan·Bevacizumab
AbbVie
Phase 1
694
California, Illinois, Indiana, Kentucky, Michigan, Minnesota, Nebraska, North Carolina
2021-11-01
Active, closed
AlloSure Lung Assessment and Metagenomics Outcomes Study
NCT05050955Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection
CareDx
Observational
550
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Maryland
2021-10-29
Recruiting
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma
NCT04989803Relapsed and/or Refractory B-cell Lymphoma
DrugsKITE-753·KITE-363·Fludarabine·Cyclophosphamide
Kite, A Gilead Company
Phase 1/2
247
Arizona, California, Florida, Georgia, Illinois, Kentucky, Maryland, Minnesota
2021-10-27
Active, closed
ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03)
NCT04829604HER2 Positive Metastatic Breast Cancer
DrugARX788
Ambrx, Inc.
Phase 2
72
California, Georgia, Illinois, Kentucky, Maryland, Massachusetts, Missouri, Nebraska
2021-10-26
Active, closed
Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
NCT05113251Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer
DrugsHerzuma·Perjeta·Herceptin·Adriamycin
AstraZeneca
Phase 3
927
Arkansas, California, Connecticut, Indiana, Kentucky, Louisiana, Minnesota, Nevada
2021-10-25
Active, closed
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
NCT05050942Gastro-enteropancreatic Neuroendocrine Tumor
DrugsCAM2029·Octreotide LAR
Camurus AB
Phase 3
332
Arizona, California, Colorado, Florida, Kentucky, Louisiana, Massachusetts, Minnesota
2021-10-22
Recruiting
US National OCS Liver Perfusion (OLP) Registry
NCT05940857Liver Transplant
TransMedics
Observational
100,000
Alabama, Arizona, California, Florida, Georgia, Kentucky, Massachusetts, Michigan
2021-10-14
Active, closed
A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
NCT04895696Systemic Lupus Erythematosus
Beeline Medicines Corporation
Phase 2
248
Alabama, California, Florida, Georgia, Illinois, Kentucky, Louisiana, Maryland
2021-10-11
Active, closed
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
NCT04971226Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive
DrugsBosutinib·Asciminib·ABL001·Nilotinib
Novartis Pharmaceuticals
Phase 3
405
Colorado, Florida, Kentucky, Massachusetts, North Carolina, Oregon, South Dakota, Tennessee
2021-10-06
Active, closed
A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer
NCT04975308Breast Neoplasms, Neoplasm Metastasis
DrugsImlunestrant·Exemestane·Abemaciclib·Fulvestrant
Eli Lilly and Company
Phase 3
874
Arizona, California, Colorado, Florida, Hawaii, Illinois, Indiana, Kentucky
2021-10-04
Active, closed
BOLT-DVT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis
NCT05003843Deep Vein Thrombosis, DVT
Penumbra Inc.
Not applicable
229
California, Delaware, District of Columbia, Florida, Illinois, Indiana, Kentucky, Louisiana
2021-09-30
Recruiting
JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization
NCT05064540AAA, AAA - Abdominal Aortic Aneurysm
Endologix
Not applicable
450
Alabama, Arizona, Arkansas, California, District of Columbia, Florida, Iowa, Kentucky
2021-09-20
Active, closed
A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
NCT04965493Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsRiabni·Ruxience·Truxima·Pirtobrutinib
Loxo Oncology, Inc.
Phase 3
600
Arizona, California, Connecticut, Florida, Iowa, Kentucky, Maryland, Massachusetts
2021-09-20
Active, closed
OCS Heart Perfusion Post-Approval Registry
NCT05047068Transplant
TransMedics
Observational
350
California, Connecticut, Florida, Georgia, Illinois, Kentucky, Massachusetts, Michigan
2021-09-13
Recruiting
Perform Humeral System Study
NCT05067543Osteoarthritis Shoulder, Avascular Necrosis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Tear Arthropathy
Stryker Trauma and Extremities
Observational
300
Kentucky, Minnesota, Missouri, Ohio, South Dakota, Utah
2021-09-12
Recruiting
Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib
NCT04486833Carcinoma, Non-Small Cell Lung
DrugsQuaratusugene ozeplasmid·Tagrisso·Osimertinib
Genprex, Inc.
Phase 1/2
158
California, Colorado, Illinois, Kentucky, Maryland, New Jersey, Ohio, Texas
2021-09-03
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04961996Early Breast Cancer
DrugGiredestrant
Hoffmann-La Roche
Phase 3
4,170
Alabama, California, Colorado, Connecticut, Florida, Illinois, Kansas, Kentucky
2021-08-27
Active, closed
MElanoma Research Lymph Node Prediction Implementation National_001
NCT04759781Melanoma
SkylineDx
Observational
1,820
Florida, Georgia, Kentucky, Michigan, Minnesota, New York, North Carolina, Utah
2021-08-25
Active, closed
Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
NCT04938817Small Cell Lung Carcinoma
DrugsMK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab·R-DXd
Merck Sharp & Dohme LLC
Phase 1/2
110
Arizona, Georgia, Indiana, Kentucky, Maryland, Nebraska, Ohio, Pennsylvania
2021-08-19
Active, closed
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
NCT04923893Multiple Myeloma
DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine
Janssen Research & Development, LLC
Phase 3
743
California, Connecticut, Florida, Iowa, Kentucky, Maryland, Massachusetts, Michigan
2021-08-19
Active, closed
Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma
NCT04674683Unresectable or Metastatic Melanoma, Progressive Brain Metastasis
DrugsChidamide·Nivolumab
HUYABIO International, LLC.
Phase 3
450
California, Florida, Indiana, Kentucky, Maryland, Missouri, Montana, North Carolina
2021-08-12
Active, closed
Study of Pembrolizumab (MK-3475) Subcutaneous (SC) Versus Pembrolizumab Intravenous (IV) Administered With Platinum Doublet Chemotherapy in Participants With Metastatic Squamous or Nonsquamous Non-Small Cell Lung Cancer (NSCLC) (MK-3475-A86)
NCT04956692Non-Small Cell Lung Cancer
DrugsAbraxane·Paraplatin·Taxol·Nab-paclitaxel
Merck Sharp & Dohme LLC
Phase 3
531
Arkansas, California, Florida, Indiana, Kentucky, Missouri, Montana, New York
2021-08-05
Active, closed
Study to Evaluate the Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases
NCT04640142Primary Immune Deficiency
Octapharma
Phase 3
50
California, Colorado, Florida, Illinois, Kansas, Kentucky, Maryland, Missouri
2021-08-04
Active, closed
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
NCT04790370Pulmonary Embolism
DrugsLMWH·Heparin
Boston Scientific Corporation
Phase 4
544
Alabama, California, Delaware, Georgia, Indiana, Kentucky, Maryland, Massachusetts
2021-08-02
Recruiting
Zimmer Biomet Shoulder Arthroplasty PMCF
NCT04984291Shoulder Fractures, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Deformity
Zimmer Biomet
Not applicable
584
California, Colorado, Illinois, Kentucky, Michigan, Minnesota, Mississippi, Missouri
2021-07-28
Active, closed
Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing
NCT04798768Tachycardia, Ventricular, Arrhythmia, Ventricular
Boston Scientific Corporation
Not applicable
297
Arizona, Arkansas, Florida, Georgia, Kentucky, Minnesota, New Jersey, New York
2021-07-20
Active, closed
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment
NCT04908189Psoriatic Arthritis
DrugsApremilast·Deucravacitinib
Bristol-Myers Squibb
Phase 3
729
Alabama, California, Illinois, Kentucky, Louisiana, Maryland, Michigan, Minnesota
2021-07-15
Active, closed
FT819 in Subjects With B-cell Malignancies
NCT04629729Lymphoma, B-Cell, Chronic Lymphocytic Leukemia, Precursor B-Cell Acute Lymphoblastic Leukemia
DrugsFT819·Fludara·Aldesleukin·Bendamustine
Fate Therapeutics
Phase 1
54
Alabama, Arizona, California, Florida, Iowa, Kansas, Kentucky, Minnesota
2021-07-12
Active, closed
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution
NCT05044819Lennox Gastaut Syndrome, Dravet Syndrome, Tuberous Sclerosis Complex
DrugCannabidiol
Jazz Pharmaceuticals
Phase 4
154
Arkansas, California, Florida, Georgia, Kansas, Kentucky, Maryland, Massachusetts
2021-07-07
Active, closed
Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer
NCT04906395Breast Cancer
DrugsTOL2506·Tamoxifen·Exemestane·Anastrozole
Tolmar Inc.
Phase 3
250
California, Colorado, Illinois, Kentucky, Maryland, Nebraska, New York, Ohio
2021-07-01
Recruiting
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
NCT04965675Chronic Migraine in Children
DrugEptinezumab
H. Lundbeck A/S
Phase 3
285
Connecticut, District of Columbia, Florida, Georgia, Kentucky, Maryland, Michigan, New York
2021-06-30
Recruiting
Persona Revision Knee System Outcomes
NCT04821154Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis
Zimmer Biomet
Observational
380
Arkansas, California, Colorado, Indiana, Kentucky, Michigan, Minnesota, Missouri
2021-06-14
Active, closed
3Spine Lumbar Fusion Real World Evidence Study
NCT04823858Lumbar Spine Degeneration
3Spine
Observational
176
California, Colorado, Florida, Kentucky, Louisiana, Minnesota, New York, North Carolina
2021-05-25
Recruiting
A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
NCT04811560Acute Leukemia
DrugBleximenib
Janssen Research & Development, LLC
Phase 1/2
420
California, Illinois, Indiana, Kentucky, Massachusetts, Michigan, New Mexico, New York
2021-05-19
Active, closed
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme
NCT04762069Glioblastoma Multiforme, Adult
DrugsCCNU·Lomustine
CNS Pharmaceuticals, Inc.
Phase 2
252
Arkansas, California, Colorado, Florida, Georgia, Illinois, Kentucky, Louisiana
2021-05-18
Recruiting
GORE® ENFORM Biomaterial Product Study
NCT04718168Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
W.L.Gore & Associates
Not applicable
245
California, Colorado, Florida, Illinois, Kentucky, North Carolina, South Carolina, Texas
2021-05-17
Recruiting
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
NCT07218029Pulmonary Arterial Hypertension
DrugSotatercept
Merck Sharp & Dohme LLC
Phase 3
815
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Kansas, Kentucky
2021-05-12
Active, closed
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092Diffuse Large B-cell Lymphoma
DrugsTafasitamab·Vincristine·Doxorubicin·Prednisone
Incyte Corporation
Phase 3
899
Alabama, California, Colorado, Florida, Hawaii, Kansas, Kentucky, Maryland
2021-05-11
Active, closed
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
NCT04675333Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
DrugsEvorpacept·Cisplatin/Carboplatin·Fluorouracil·Keytruda
ALX Oncology Inc.
Phase 2
172
California, Florida, Illinois, Kentucky, Maryland, New York, Ohio, Oregon
2021-05-10
Active, closed
Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer
DrugsCapivasertib·Abemaciclib·Ribociclib·Palbociclib
AstraZeneca
Phase 3
893
Arizona, California, Colorado, Connecticut, Delaware, Kentucky, Maryland, Massachusetts
2021-05-10
Recruiting
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
NCT04614103Metastatic Non Small Cell Lung Cancer
Iovance Biotherapeutics, Inc.
Phase 2
170
Arizona, Florida, Illinois, Kentucky, Maryland, Michigan, Minnesota, Nebraska
2021-05-07
Recruiting
Ventral or Inguinal Hernia, Robotically Repaired With OviTex Mesh
NCT04779918Hernia, Ventral, Hernia, Inguinal
Tela Bio Inc
Not applicable
160
Alabama, Colorado, Florida, Kansas, Kentucky, Michigan, New York, Texas
2021-04-29
Active, closed
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
NCT04784715Breast Cancer; HER2-positive; Metastatic
DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab
AstraZeneca
Phase 3
1,157
Arizona, Arkansas, California, Colorado, Florida, Georgia, Kentucky, Maryland
2021-04-26
Active, closed
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
NCT04700124Bladder Cancer
DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
808
Arizona, California, Colorado, Florida, Indiana, Iowa, Kentucky, New York
2021-04-21
Active, closed
A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML
NCT04730258Acute Myeloid Leukemia, Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, AML
DrugsCFI-400945·Azacitidine
Treadwell Therapeutics, Inc
Phase 1/2
72
California, Kentucky, New York, Ohio, Texas
2021-04-16
Active, closed
A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.
NCT04680052Follicular Lymphoma, Marginal Zone Lymphoma
DrugsTafasitamab·Lenalidomide·Rituximab
Incyte Corporation
Phase 3
654
California, Connecticut, Florida, Georgia, Hawaii, Iowa, Kentucky, Louisiana
2021-04-15
Active, closed
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
NCT04736706Carcinoma, Renal Cell
DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda
Merck Sharp & Dohme LLC
Phase 3
1,688
Alabama, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2021-04-14
Active, closed
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
NCT04576156Myelofibrosis
DrugImetelstat Sodium
Geron Corporation
Phase 3
327
California, Connecticut, Florida, Kentucky, New York, North Carolina, Ohio, South Dakota
2021-04-12
Active, closed
Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
DrugsPelabresib·Ruxolitinib
Novartis Pharmaceuticals
Phase 3
430
Alabama, Arizona, California, Connecticut, Florida, Illinois, Indiana, Kentucky
2021-04-09
Active, closed
Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
NCT04662255Lymphoma, Mantle-Cell
DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib
Loxo Oncology, Inc.
Phase 3
500
Alaska, Arizona, California, Colorado, Florida, Kentucky, Louisiana, Maryland
2021-04-08
Active, closed
Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)
NCT04365374Brain Metastases
GT Medical Technologies, Inc.
Phase 3
230
Arizona, Arkansas, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky
2021-04-06
Active, closed
Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)
NCT04816604Pulmonary Arterial Hypertension
DrugSeralutinib
Gossamer Bio USA, Inc.
Phase 2
74
California, Florida, Kansas, Kentucky, Massachusetts, Nebraska, New York, Ohio
2021-04-05
Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
DrugNemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
490
Arkansas, California, Colorado, Kentucky, Minnesota, New Jersey, North Dakota, Texas
2021-04-05
Active, closed
Antibody Persistence And Long Term Safety Of A Chikungunya Virus Vaccine (VLA1553)
NCT04838444Chikungunya Virus Infection
Valneva Austria GmbH
Phase 3
363
Arizona, Florida, Illinois, Kentucky, Nebraska, Tennessee, Texas, Utah
2021-04-02
Active, closed
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
NCT04562389Myelofibrosis
DrugsSelinexor·Ruxolitinib
Karyopharm Therapeutics Inc
Phase 3
353
Alabama, California, Colorado, Connecticut, District of Columbia, Kentucky, Maryland, Michigan
2021-03-11
Active, closed
A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma
NCT04594642B-cell Non Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma
DrugSurovatamig
AstraZeneca
Phase 1
226
Florida, Kentucky, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Wisconsin
2021-03-02
Active, closed
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231Carcinoma, Renal Cell
DrugsBelzutifan·Cabozantinib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
747
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Kentucky
2021-02-25
Active, closed
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
313
California, Florida, Illinois, Kentucky, Michigan, Missouri, New Jersey, New York
2021-02-25
Active, closed
Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment
NCT04647526Metastatic Castration-Resistant Prostate Cancer
DrugsAbiraterone·Enzalutamide
POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company
Phase 3
455
Arizona, California, Colorado, Florida, Iowa, Kentucky, Louisiana, Maryland
2021-02-25
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
DrugsAdagrasib·Taxotere·Docetaxel
Mirati Therapeutics Inc.
Phase 3
453
California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky
2021-02-23
Active, closed
A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer
NCT03899636Stage III Pancreatic Cancer
DrugModified FOLFIRINOX
Angiodynamics, Inc.
Phase 3
528
Florida, Illinois, Kentucky, Pennsylvania, Texas
2021-02-23
Active, closed
MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb
NCT04649359Multiple Myeloma
DrugElranatamab
Pfizer
Phase 2
187
California, Florida, Georgia, Illinois, Kentucky, Louisiana, New Jersey, New York
2021-02-02
Active, closed
Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
NCT04755283Atrial Fibrillation (AF), Stroke
DrugsAbelacimab·Rivaroxaban
Anthos Therapeutics, Inc.
Phase 2
1,287
Alabama, Connecticut, Florida, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2021-02-02
Recruiting
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
NCT03127267Amyotrophic Lateral Sclerosis
DrugsMasitinib·Riluzole
AB Science
Phase 3
495
Alabama, California, Kentucky, Maryland, Massachusetts, Virginia
2021-02-02
Recruiting
A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04634552Hematological Malignancies
DrugTalquetamab
Janssen Research & Development, LLC
Phase 2
510
Alabama, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Michigan
2021-02-01
Active, closed
A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)
NCT04628494Diffuse Large B-cell Lymphoma
DrugEpcoritamab
Genmab
Phase 3
483
Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas
2021-01-13
Active, closed
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
NCT04534205Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
DrugPembrolizumab
BioNTech SE
Phase 2/3
358
California, Connecticut, District of Columbia, Florida, Georgia, Kentucky, Massachusetts, New Mexico
2021-01-07
Recruiting
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
NCT04669548Intraabdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury, Cardiovascular Surgery
Potrero Medical
Observational
2,500
California, District of Columbia, Florida, Kentucky, North Carolina, Ohio
2020-12-21
Active, closed
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
NCT04305795Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head-and-neck Squamous-cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
DrugsCemiplimab·Pembrolizumab
Rakuten Medical, Inc.
Phase 1/2
23
Florida, Kentucky, Minnesota, Oregon, Pennsylvania, Tennessee, Texas
2020-12-21
Active, closed
Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)
NCT04656652Non-small Cell Lung Cancer
DrugsDato-DXd·Docetaxel
Daiichi Sankyo
Phase 3
605
Arizona, California, Florida, Illinois, Indiana, Kentucky, Louisiana, Maryland
2020-12-21
Active, closed
Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thrombocytopenia (ITP)
NCT04562766Immune Thrombocytopenia
DrugRilzabrutinib
Principia Biopharma, a Sanofi Company
Phase 3
232
California, Colorado, Florida, Georgia, Illinois, Kentucky, Massachusetts, New York
2020-12-14
Active, closed
A Study to Assess Safety and Efficacy of PRL3-Zumab in Patients With Solid Tumors
NCT04452955Solid Tumor
DrugPRL3-ZUMAB
Intra-IMMUSG Pte Ltd
Phase 2
51
Arizona, California, Kentucky, Nevada
2020-12-12
Active, closed
Atrasentan in Patients With IgA Nephropathy
NCT04573478IgA Nephropathy, Immunoglobulin A Nephropathy
DrugsAtrasentan·Zigakibart
Novartis Pharmaceuticals
Phase 3
404
Alabama, California, Florida, Georgia, Illinois, Indiana, Kentucky, Massachusetts
2020-12-11
Active, closed
Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy
NCT04655976Lung Cancer, Non-Small Cell
DrugsCobolimab·Dostarlimab·Docetaxel
GlaxoSmithKline
Phase 2/3
758
California, Connecticut, District of Columbia, Hawaii, Iowa, Kentucky, Nevada, New York
2020-12-08
Active, closed
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
NCT04624204Small Cell Lung Cancer
DrugsOlaparib·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
672
Arizona, California, District of Columbia, Florida, Illinois, Indiana, Kentucky, Louisiana
2020-12-08
Active, closed
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
NCT04622319HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
DrugsAdo-trastuzumab emtansine·Trastuzumab deruxtecan
Daiichi Sankyo
Phase 3
1,600
California, Florida, Illinois, Kentucky, Louisiana, Maryland, New York, North Carolina
2020-12-04
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
NCT04548999Multiple Sclerosis
DrugsOcrelizumab·Methylprednisolone
Hoffmann-La Roche
Phase 3
769
Alabama, Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts
2020-12-03
Recruiting
A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease
NCT04671771End Stage Renal Disease (ESRD), Kidney Failure, Chronic Renal Disease, Hemodialysis
W.L.Gore & Associates
Not applicable
133
Arizona, Florida, Georgia, Kentucky, Maryland, Massachusetts, New Jersey, New York
2020-12-03
Active, closed
Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
NCT04592913Gastrointestinal Neoplasms, Esophagogastric Junction
DrugDurvalumab
AstraZeneca
Phase 3
957
California, Florida, Indiana, Kentucky, Massachusetts, New York, Tennessee, Texas
2020-11-17
Recruiting
Study of PF-07248144 in Advanced or Metastatic Solid Tumors
NCT04606446Locally Advanced or Metastatic ER+ HER2- Breast Cancer, Locally Advanced or Metastatic Castration-resistant Prostate Cancer, Locally Advanced or Metastatic Non-small Cell Lung Cancer
DrugsPrifetrastat·Atirmociclib·Palbociclib·Letrozole
Pfizer
Phase 2
320
Arizona, California, Connecticut, Florida, Kentucky, Tennessee, Texas, Washington
2020-11-16
Active, closed
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
NCT04301518Preterm Labor, Preterm Birth
Sera Prognostics, Inc.
Not applicable
6,500
California, Connecticut, Delaware, Florida, Kentucky, Louisiana, Massachusetts, Michigan
2020-11-06
Recruiting
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
NCT04329728Lymphoid Malignancies
AVM Biotechnology Inc
Phase 1/2
144
California, Florida, Illinois, Kentucky, Nebraska, Ohio, Tennessee, Texas
2020-11-06
Active, closed
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)
NCT04524871Advanced Liver Cancers
DrugsADG126·Tobemstomig·Tiragolumab·Tocilizumab
Hoffmann-La Roche
Phase 1/2
518
California, Colorado, Connecticut, District of Columbia, Kentucky, Oregon, Tennessee, Texas
2020-11-01
Active, closed
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
NCT04464226Cancer
DrugDarolutamide
Bayer
Phase 3
402
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Maryland
2020-10-20
Active, closed
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
NCT04446117Metastatic Prostate Cancer, Prostate Adenocarcinoma
DrugsZytiga·Xtandi·Abiraterone·Abiraterone acetate
Exelixis
Phase 3
575
Arizona, California, Colorado, Connecticut, Florida, Georgia, Kansas, Kentucky
2020-10-19
Active, closed
Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC
NCT04550260Esophageal Squamous Cell Carcinoma
DrugsFluorouracil·Durvalumab·Capecitabine·Cisplatin
AstraZeneca
Phase 3
640
Georgia, Kentucky, Texas, Virginia, West Virginia
2020-10-19
Active, closed
Study to Evaluate D-1553 in Subjects With Solid Tumors
NCT04585035Solid Tumor, Adult, NSCLC, CRC
DrugD-1553
InventisBio Co., Ltd
Phase 1/2
180
California, Kentucky, Michigan, New York, Oregon
2020-10-02
Active, closed
Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)
NCT04524611Crohn's Disease (CD)
DrugsSkyrizi·Risankizumab·Ustekinumab
AbbVie
Phase 3
527
Arizona, California, Connecticut, Florida, Georgia, Illinois, Kentucky, Louisiana
2020-09-30
Active, closed
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP, an Autoimmune Disorder That Affects the Peripheral Nerves)
NCT04280718Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
DrugEfgartigimod PH20
argenx
Phase 2
229
Alabama, Arizona, California, Colorado, Florida, Iowa, Kansas, Kentucky
2020-09-18
Active, closed
PF-07104091 as a Single Agent and in Combination Therapy
NCT04553133Small Cell Lung Cancer, Ovarian Cancer, Breast Cancer
DrugsPF-07104091·Palbociclib·Letrozole·Fulvestrant
Pfizer
Phase 2
157
Iowa, Kentucky, Massachusetts, New Jersey, New York, Virginia
2020-09-16
Active, closed
Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
NCT04140526Non Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Melanoma, Metastatic Head and Neck Carcinoma
DrugsGotistobart·Taxotere·Docetaxel·Keytruda
OncoC4, Inc.
Phase 1/2
733
Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Kentucky
2020-09-16
Active, closed
Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
NCT04384484Relapsed Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
DrugsLoncastuximab Tesirine·Rituximab·Oxaliplatin·Gemcitabine
ADC Therapeutics S.A.
Phase 3
440
California, Florida, Iowa, Kentucky, Nevada, Oregon, South Carolina, Virginia
2020-09-16
Active, closed
Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients)
NCT01817192Non-Small Cell Lung Cancer
Razor Genomics
Not applicable
420
California, Florida, Kentucky, Missouri, New Jersey, North Carolina, Oklahoma, Pennsylvania
2020-09-11
Active, closed
A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
NCT04442022Relapsed/Refractory Diffuse Large B-cell Lymphoma
DrugsSelinexor·Rituximab·Dexamethasone·Gemcitabine
Karyopharm Therapeutics Inc
Phase 2/3
501
Arizona, California, Kentucky, Maryland, New York, Texas
2020-09-03
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma
NCT04246086Follicular Lymphoma
DrugsMosunetuzumab·Tocilizumab·Lenalidomide
Hoffmann-La Roche
Phase 1/2
237
California, Florida, Kentucky, Louisiana, Michigan, North Carolina, Ohio, Rhode Island
2020-08-12
Active, closed
A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies
NCT04227847Myelodysplastic Syndrome, Acute Myeloid Leukemia
DrugsVenclexta·Azacitidine·Venetoclax
Seagen, a wholly owned subsidiary of Pfizer
Phase 1
170
Alabama, California, Colorado, Kansas, Kentucky, Massachusetts, Michigan, Missouri
2020-08-07
Recruiting
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
NCT04300556Solid Tumor
DrugsPrednisolone·Lenvatinib·Prednisone·Dexamethasone
Eisai Inc.
Phase 1/2
182
Arizona, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Maryland
2020-08-06
Active, closed
Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA
NCT04325022Advanced Degeneration of the Hip Joint, Revision of the Hip Joint
Smith & Nephew, Inc.
Observational
177
Kentucky, Nebraska, New York, North Carolina, Texas
2020-07-27
Active, closed
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
NCT04494425Advanced or Metastatic Breast Cancer
DrugsTrastuzumab deruxtecan·Nab-paclitaxel·Capecitabine·Paclitaxel
AstraZeneca
Phase 3
866
Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Kansas, Kentucky
2020-07-24
Active, closed
RETHINK REFLUX Registry
NCT04253392Gastroesophageal Reflux
Ethicon Endo-Surgery
Observational
500
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Michigan
2020-07-08
Active, closed
Evaluation of Safety and Effectiveness of Stryker Surpass Evolve™ Flow Diverter System
NCT04195568Aneurysm, Intracranial
Stryker Neurovascular
Not applicable
248
Arizona, California, Florida, Illinois, Indiana, Iowa, Kansas, Kentucky
2020-07-07
Active, closed
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
NCT04380636Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
DrugsParaplatin·Taxol·Olaparib·Etoposide
Merck Sharp & Dohme LLC
Phase 3
870
Alabama, Arkansas, California, Florida, Indiana, Kentucky, Massachusetts, Michigan
2020-07-06
Active, closed
Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System
NCT04201132Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis
Contego Medical, Inc.
Not applicable
305
Alabama, California, District of Columbia, Florida, Iowa, Kentucky, Louisiana, Maryland
2020-06-12
Active, closed
Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma, Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPHA2)
NCT04416984Relapsed or Refractory Large B Cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma
DrugsALLO-647·Fludarabine·Cyclophosphamide
Allogene Therapeutics
Phase 1/2
160
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2020-05-21
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
NCT04241185Urinary Bladder Neoplasms
DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda
Merck Sharp & Dohme LLC
Phase 3
520
District of Columbia, Florida, Kentucky, Maryland, Missouri, New Jersey, New York, Ohio
2020-05-19
Recruiting
CERAMENT™| Bone Void Filler Device Registry
NCT04244942Orthopedic Disorder
BONESUPPORT AB
Observational
300
Arizona, Florida, Indiana, Kentucky, Massachusetts, New York, North Carolina, Ohio
2020-03-30
Active, closed
Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD
NCT04229017Degenerative Disc Disease
Providence Medical Technology, Inc.
Not applicable
236
Arizona, California, Colorado, Illinois, Kentucky, Louisiana, Maryland, Michigan
2020-03-18
Active, closed
Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)
NCT04199689Papillomavirus Infections
DrugNonavalent HPV vaccine
Merck Sharp & Dohme LLC
Phase 3
6,033
California, Florida, Georgia, Idaho, Kansas, Kentucky, Missouri, Nevada
2020-02-27
Active, closed
Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET
NCT03972488Gastro-enteropancreatic Neuroendocrine Tumor
DrugsOctreotide LAR·Lutathera
Advanced Accelerator Applications
Phase 3
226
Connecticut, Florida, Iowa, Kentucky, Minnesota, Texas
2020-01-08
Active, closed
Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia
NCT04150887Leukemia, Myeloid, Acute
DrugsCusatuzumab·Venclexta·Azacitidine·Venetoclax
OncoVerity, Inc.
Phase 1
61
California, Kentucky, Michigan, New York, Pennsylvania, Texas, Vermont, Wisconsin
2019-12-23
Recruiting
KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)
NCT04165798Carcinoma, Non-Small-Cell Lung
Merck Sharp & Dohme LLC
Observational
1,065
Arizona, California, District of Columbia, Kentucky, Maryland, Massachusetts, Nebraska, New Hampshire
2019-12-19
Recruiting
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
NCT04165070Carcinoma, Non-Small-Cell Lung
DrugsMK-4830·Ifinatamab Deruxtecan·Patritumab deruxtecan·Abraxane
Merck Sharp & Dohme LLC
Phase 1/2
450
Arizona, California, District of Columbia, Kentucky, Maryland, Massachusetts, Nebraska, New Hampshire
2019-12-19
Active, closed
Neuspera's Implantable Sacral Nerve Stimulation System in Patients With Symptoms of Urinary Urgency Incontinence (UUI)
NCT04232696Urinary Urgency Incontinence
Neuspera Medical, Inc.
Not applicable
331
California, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky, Louisiana
2019-12-13
Active, closed
Prophylactic Reinforcement of Ventral Abdominal Incisions Trial
NCT03911700Open Midline Laparotomy
C. R. Bard
Not applicable
477
Arizona, California, Connecticut, Georgia, Illinois, Indiana, Kentucky, Louisiana
2019-12-12
Recruiting
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
NCT04198766Solid Tumor, Non-Small Cell Lung Cancer, Head and Neck Cancer, Melanoma
DrugsCarboplatin (AUC 5)·Carboplatin (AUC 6)·Nab-paclitaxel·Pemetrexed
Inhibrx Biosciences, Inc
Phase 1/2
340
California, Florida, Georgia, Illinois, Iowa, Kentucky, Michigan, Minnesota
2019-12-10
Recruiting
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
Abbott Medical Devices
Observational
1,000
Arizona, California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky
2019-11-26
Active, closed
A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies
NCT03888105B-cell Non-Hodgkin Lymphoma (B-NHL)
DrugOdronextamab
Regeneron Pharmaceuticals
Phase 2
515
Illinois, Iowa, Kentucky, Massachusetts, Minnesota, New Jersey, New York, North Carolina
2019-11-13
Active, closed
A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm
NCT04041050Myeloproliferative Neoplasm
DrugsNavitoclax·Celebrex·Celecoxib·Ruxolitinib
AbbVie
Phase 1
85
California, Illinois, Kentucky, Michigan, Nebraska, North Carolina, Ohio, Pennsylvania
2019-11-08
By invitation
MDR - Comprehensive Reverse/Versa Dial Ti Glenosphere
NCT04003272Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Arthritis
Zimmer Biomet
Observational
59
Kentucky, New York
2019-10-28
Active, closed
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
NCT04123626Autosomal Dominant Retinitis Pigmentosa, Eye Diseases, Eye Diseases, Hereditary, Retinal Dystrophies
ProQR Therapeutics
Phase 1/2
11
Colorado, Florida, Kentucky, Oregon, Texas
2019-10-07
Active, closed
SyncAV Post-Market Trial
NCT04100148Congestive Heart Failure
Abbott Medical Devices
Not applicable
1,686
Alabama, Arizona, California, Colorado, Florida, Georgia, Iowa, Kentucky
2019-10-03
Active, closed
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04033445Ulcerative Colitis
DrugGuselkumab
Janssen Research & Development, LLC
Phase 2/3
1,064
California, Colorado, Florida, Georgia, Illinois, Kansas, Kentucky, Massachusetts
2019-09-26
Active, closed
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
NCT04083599Malignant Solid Tumor, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Melanoma
DrugsGEN1042·Adrucil·Nab-paclitaxel·Pemetrexed
Genmab
Phase 1/2
350
Alaska, California, Connecticut, Delaware, Florida, Illinois, Kentucky, Maryland
2019-09-17
Active, closed
Observational Evaluation of Atopic Dermatitis in Pediatric Patients
NCT03687359Dermatitis Atopic
Sanofi
Observational
1,860
Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Kentucky
2019-08-15
Active, closed
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
NCT04012996Symptomatic Cervical Disc Disease
Centinel Spine
Not applicable
390
Arizona, California, Colorado, District of Columbia, Florida, Indiana, Kentucky, Louisiana
2019-08-05
Recruiting
Safety and Preliminary Efficacy of OBT076 in Recurrent/Metastatic CD205+ Solid Tumors
NCT04064359Solid Tumor
Oxford BioTherapeutics Ltd
Phase 1
200
Arizona, California, Florida, Iowa, Kentucky, Mississippi, New Mexico, New York
2019-07-25
Active, closed
A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer
NCT03981796Neoplasms
DrugsNiraparib·Dostarlimab·Paclitaxel·Carboplatin
Tesaro, Inc.
Phase 3
785
Arizona, California, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky
2019-07-18
Active, closed
Citadel Embolization Device Study
NCT04057352Unruptured Wide-neck Aneurysms
Stryker Neurovascular
Not applicable
150
California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky, Massachusetts
2019-07-18
Recruiting
Assessment of Anti-tumor and Safety in Glumetinib in Patients With c-MET-positive Non-Small Cell Lung Cancer
NCT04270591C-Met Exon 14 Mutation
DrugGlumetinib
Haihe Biopharma Co., Ltd.
Phase 1/2
183
Kentucky
2019-07-15
Active, closed
A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)
NCT04035486Non-Small Cell Lung Cancer
DrugsPemetrexed/Cisplatin·Pemetrexed/Carboplatin·Osimertinib
AstraZeneca
Phase 3
587
California, Florida, Kansas, Kentucky, Massachusetts, Nevada, New York, Ohio
2019-07-02
Active, closed
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis
NCT03725007Juvenile Idiopathic Arthritis (JIA)
DrugUpadacitinib
AbbVie
Phase 1
124
Illinois, Kentucky, Massachusetts, Ohio, Oregon, Pennsylvania, Washington
2019-06-24
Active, closed
remedē System Therapy Study
NCT03884660Central Sleep Apnea
Respicardia, Inc.
Observational
225
Arizona, California, Colorado, Florida, Georgia, Illinois, Kentucky, Michigan
2019-06-18
Active, closed
Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma
NCT03969004Cutaneous Squamous Cell Carcinoma
DrugCemiplimab
Regeneron Pharmaceuticals
Phase 3
415
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Maryland
2019-06-04
Active, closed
Evaluation of the Safety and Efficacy of TLD in Patients with COPD
NCT03639051COPD
Nuvaira, Inc.
Not applicable
464
Alabama, Arizona, California, Florida, Illinois, Kentucky, Massachusetts, Michigan
2019-05-23
Active, closed
A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants
NCT03253263Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Intraventricular Hemorrhage, Retinopathy of Prematurity (ROP)
OHB Neonatology Ltd.
Phase 2
295
Arkansas, California, Florida, Illinois, Indiana, Kentucky, Louisiana, Massachusetts
2019-05-09
Active, closed
ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy
NCT03769506Head and Neck Cancer
Rakuten Medical, Inc.
Phase 3
135
Florida, Georgia, Kentucky, Pennsylvania, Texas
2019-05-09
Active, closed
A Registry Study of NanoKnife IRE for Stage 3 Pancreatic Cancer
NCT03899649Stage III Pancreatic Cancer
Angiodynamics, Inc.
Observational
532
California, Florida, Georgia, Illinois, Iowa, Kentucky, Minnesota, Missouri
2019-05-08
Active, closed
Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer (TOPAZ-1)
NCT03875235Biliary Tract Neoplasms
DrugDurvalumab
AstraZeneca
Phase 3
810
California, District of Columbia, Florida, Kansas, Kentucky, Massachusetts, Missouri, North Carolina
2019-04-16
Active, closed
Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella
NCT03873545Cartilage Injury, Cartilage Damage
AlloSource
Observational
34
Illinois, Kentucky, Ohio
2019-03-18
Active, closed
A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer
NCT03816163Pancreatic Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma
DrugsZolbetuximab·Nab-paclitaxel·Gemcitabine
Astellas Pharma Global Development, Inc.
Phase 2
393
California, Connecticut, Florida, Georgia, Illinois, Kentucky, Louisiana, Missouri
2019-03-15
Active, closed
Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT03836261Chronic Lymphocytic Leukemia
DrugsVenclyxto·Acalabrutinib·Venclexta·Obinutuzumab
Acerta Pharma BV
Phase 3
984
California, Indiana, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, New York
2019-02-25
Active, closed
Clinical Trial Multi-analyte Blood Test
NCT03694600Liver Cirrhosis
Helio Genomics
Observational
1,900
Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas, Kentucky
2019-02-04
Recruiting
Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple Myeloma
NCT03761108Multiple Myeloma
DrugLinvoseltamab
Regeneron Pharmaceuticals
Phase 1/2
387
Florida, Georgia, Indiana, Kentucky, Michigan, New Jersey, New York, Ohio
2019-01-23
Active, closed
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
NCT03682536Myelodysplastic Syndromes
DrugsEpoetin Alfa·Luspatercept
Celgene
Phase 3
363
California, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Missouri, New Jersey
2019-01-02
Active, closed
Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors
NCT03836352Ovarian Cancer, Hepatocellular Carcinoma, Non-small Cell Lung Cancer, Bladder Cancer
DrugsCyclophosphamide·Pembrolizumab
ImmunoVaccine Technologies, Inc. (IMV Inc.)
Phase 2
184
Arizona, California, Florida, Georgia, Kentucky, Louisiana, Minnesota, New Mexico
2018-12-21
Active, closed
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)
NCT03765918Head and Neck Neoplasms
DrugsKeytruda·Cisplatin·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
714
California, Colorado, District of Columbia, Florida, Idaho, Illinois, Kansas, Kentucky
2018-12-17
Active, closed
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)
NCT03742895Advanced Solid Neoplasms
DrugOlaparib
Merck Sharp & Dohme LLC
Phase 2
329
Arizona, California, Colorado, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2018-12-12
Active, closed
QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
NCT03228667Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Urothelial Carcinoma, Head and Neck Squamous Cell Carcinoma
DrugsPD-L1 t-haNK·Avelumab·Atezolizumab·Durvalumab
ImmunityBio, Inc.
Phase 2
40
Alaska, Arkansas, California, Florida, Indiana, Iowa, Kentucky, Massachusetts
2018-12-11
Active, closed
A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer
NCT03800134Non-Small Cell Lung Cancer
DrugsDurvalumab·Pemetrexed·Gemcitabine·Paclitaxel
AstraZeneca
Phase 3
825
Arizona, California, Colorado, Florida, Illinois, Kansas, Kentucky, Maryland
2018-12-06
Active, closed
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
NCT03732677Muscle Invasive Bladder Cancer
DrugsDurvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,063
Alabama, California, Connecticut, Illinois, Iowa, Kansas, Kentucky, Louisiana
2018-11-16
Active, closed
Destination Therapy Post Approval Study
NCT03681210Chronic Heart Failure
Medtronic Cardiac Rhythm and Heart Failure
Observational
300
Arkansas, California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky
2018-10-31
Active, closed
A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
NCT03539744Multiple Myeloma
DrugsPomalidomide·Venetoclax·Dexamethasone
AbbVie
Phase 3
265
Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts, Michigan
2018-10-22
Active, closed
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
NCT03690388Differentiated Thyroid Cancer
DrugCabozantinib
Exelixis
Phase 3
187
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Kentucky, Massachusetts
2018-10-05
Active, closed
Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy
NCT03703297Small Cell Lung Cancer
DrugsTremelimumab·Durvalumab
AstraZeneca
Phase 3
730
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2018-09-27
Active, closed
Reducing Lung CongestIon Symptoms in Advanced Heart Failure
NCT03499236Heart Failure
V-Wave Ltd
Not applicable
605
Arizona, California, Colorado, Florida, Georgia, Illinois, Kentucky, Minnesota
2018-09-19
Active, closed
Post-Market Study of Comprehensive Reverse Augmented Glenoid and Mini Humeral Tray in Total Shoulder Arthroplasty
NCT03726554Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects
Zimmer Biomet
Not applicable
99
Florida, Kentucky, Michigan, New York, Tennessee, Virginia
2018-08-28
Active, closed
Study of Abexinostat in Patients With Relapsed or Refractory Follicular Lymphoma
NCT03600441Follicular Lymphoma
DrugAbexinostat
Xynomic Pharmaceuticals, Inc.
Phase 2
139
Illinois, Kentucky, New York, Pennsylvania, Texas, Washington
2018-08-27
Active, closed
Early Feasibility Evaluation of the AccuCinch® Ventricular Restoration System in Patients With Heart Failure and Reduced Ejection Fraction
NCT03533517Heart Failure, Cardiomyopathy, Dilated
Ancora Heart, Inc.
Not applicable
22
California, Georgia, Kentucky, Louisiana, Minnesota, Nebraska, New Jersey, New York
2018-08-23
By invitation
Advanced Materials Science in XLIF Study
NCT03649490Degenerative Disc Disease, Spondylolisthesis
NuVasive
Observational
300
Connecticut, Florida, Illinois, Kentucky, Maryland, Minnesota, Missouri, North Carolina
2018-08-19
Active, closed
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
NCT03547973Metastatic Urothelial Cancer
DrugsDomvanalimab·Zimberelimab·Avelumab·Enfortumab Vedotin
Gilead Sciences
Phase 2
502
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2018-08-13
Active, closed
DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03]
NCT03529110Breast Cancer
DrugsAdo-trastuzumab emtansine·Trastuzumab deruxtecan
Daiichi Sankyo
Phase 3
524
California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Massachusetts, Nebraska
2018-08-09
Active, closed
Post Approval Study Investigating Lutonix Drug Coated Balloon for Treatment of Dysfunctional Arteriovenous Fistulae
NCT03506308Arteriovenous Fistula
C. R. Bard
Not applicable
213
Alabama, California, Connecticut, Iowa, Kentucky, Louisiana, Maryland, Massachusetts
2018-08-07
Recruiting
A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)
NCT03592472Renal Cell Carcinoma
DrugsAbexinostat·Pazopanib
Xynomic Pharmaceuticals, Inc.
Phase 3
413
Arizona, California, Kentucky, Louisiana, Nebraska, New York, Ohio, Oregon
2018-07-17
Active, closed
A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy in Adults With Gastric Cancer.
NCT03504397Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
DrugsZolbetuximab·Folinic acid·Fluorouracil·Oxaliplatin
Astellas Pharma Global Development, Inc.
Phase 3
565
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2018-06-21
Recruiting
A Study of BI-1206 in Combination With Rituximab With or Without Acalabrutinib in Subjects With Indolent B-Cell NHL
NCT03571568Indolent B-Cell Non-Hodgkin Lymphoma
DrugsRuxience·Acalabrutinib·Rituximab
BioInvent International AB
Phase 1/2
140
Georgia, Kentucky
2018-05-16
Active, closed
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
NCT03438747Degenerative Disc Disease
CeraPedics, Inc
Not applicable
290
Alabama, California, Colorado, Connecticut, Florida, Illinois, Indiana, Kentucky
2018-04-24
Active, closed
A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT03462719Leukemia, Lymphocytic, Chronic, B-Cell
DrugsChlorambucil·Ibrutinib·Obinutuzumab·Venetoclax
Janssen Research & Development, LLC
Phase 3
211
Kentucky, New Jersey, North Carolina
2018-04-17
Recruiting
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977Metastatic Castration Resistant Prostate Cancer (mCRPC), Small Cell Lung Cancer (SCLC), Follicular Lymphoma (FL)
DrugsMevrometostat·Xtandi·Itraconazole·Enzalutamide
Pfizer
Phase 1
453
Arizona, California, Connecticut, Kansas, Kentucky, Maryland, Massachusetts, Nebraska
2018-04-17
Active, closed
Study of the Safety and Effectiveness of Motiva Implants®
NCT03579901Breast Implants
Motiva USA LLC
Not applicable
800
California, Colorado, Georgia, Illinois, Indiana, Kentucky, Louisiana, Michigan
2018-04-06
Active, closed
A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer
NCT03473743Urothelial Carcinoma
DrugsErdafitinib·Cetrelimab·Cisplatin·Carboplatin
Janssen Research & Development, LLC
Phase 1/2
125
Colorado, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania
2018-04-05
Active, closed
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations
NCT03390504Urothelial Cancer
DrugsVinflunine·Erdafitinib·Docetaxel·Pembrolizumab
Janssen Research & Development, LLC
Phase 3
629
Alaska, California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Maryland
2018-03-23
Active, closed
A Study of Durvalumab Alone and Durvalumab+Olaparib in Advanced, Platinum-Ineligible Bladder Cancer (BAYOU)
NCT03459846Urinary Bladder Neoplasms
DrugsOlaparib·Durvalumab
AstraZeneca
Phase 2
154
Alabama, Arizona, Florida, Kentucky, New York, Pennsylvania, Tennessee, Washington
2018-03-16
Active, closed
To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.
NCT03330847Metastatic Triple Negative Breast Cancer
DrugCeralasertib
AstraZeneca
Phase 2
273
Alabama, Alaska, Arizona, Colorado, Connecticut, Illinois, Indiana, Kentucky
2018-03-07
Active, closed
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
NCT03211663Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Medacta USA
Observational
269
Florida, Kentucky, Montana, North Carolina, Pennsylvania
2017-10-09
Active, closed
A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT03178552Non-Small Cell Lung Cancer
DrugsCobimetinib·Divarasib·Vemurafenib·Entrectinib
Hoffmann-La Roche
Phase 2/3
1,000
California, Colorado, Florida, Kentucky, Nevada, New Hampshire, New York, Oregon
2017-09-22
Active, closed
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
NCT03767348Non-Small Cell Lung Cancer (NSCLC), Microsatellite Instability-High (MSI-H), Non-melanoma Skin Cancer (NMSC), Cutaneous Melanoma
DrugsVusolimogene Oderparepvec·Opdivo·Nivolumab
Replimune, Inc.
Phase 2
340
Alabama, Arizona, Arkansas, California, Florida, Iowa, Kentucky, Minnesota
2017-09-20
Active, closed
ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population
NCT03153449Primary Knee Arthroplasty
DePuy Orthopaedics
Not applicable
400
California, Colorado, Connecticut, Florida, Kentucky, Mississippi, New Hampshire, New Jersey
2017-09-19
Active, closed
ADAPT - A Patient Registry of the Real-world Use of Orenitram®
NCT03045029Pulmonary Arterial Hypertension
DrugTreprostinil
United Therapeutics
Observational
300
California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky
2017-07-18
Active, closed
LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis
NCT03115983Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Empirical Spine, Inc.
Not applicable
299
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kentucky
2017-07-17
Active, closed
Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
NCT03164616Non Small Cell Lung Cancer NSCLC
DrugsTremelimumab·Abraxane·Durvalumab·Pemetrexed
AstraZeneca
Phase 3
1,186
Arizona, California, Florida, Kentucky, Missouri, Ohio, Pennsylvania, Tennessee
2017-06-01
Active, closed
ATTUNE Revision System in the Revision Total Knee Arthroplasty Population
NCT03153475Revision Total Knee Arthroplasty
DePuy Orthopaedics
Not applicable
400
California, Colorado, Connecticut, Florida, Kentucky, Mississippi, Missouri, New Hampshire
2017-05-30
Active, closed
Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.
NCT03229200Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Leukemia, B-cell, Graft Vs Host Disease
DrugIbrutinib
Pharmacyclics Switzerland GmbH
Phase 4
297
California, Georgia, Illinois, Kentucky, Massachusetts, Michigan, Nevada, New Jersey
2017-05-22
Active, closed
A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL
NCT02972840Lymphoma, Mantle Cell
DrugsAcalabrutinib·Bendamustine·Rituximab
Acerta Pharma BV
Phase 3
635
Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Kansas, Kentucky
2017-04-05
Active, closed
A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy
NCT02993523Acute Myeloid Leukemia (AML)
DrugsAzacitidine·Venetoclax
AbbVie
Phase 3
443
California, Georgia, Illinois, Indiana, Kansas, Kentucky, Maine, Maryland
2017-02-02
Active, closed
A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL
NCT02970318Chronic Lymphocytic Leukemia
DrugsIdelalisib·Acalabrutinib·Bendamustine·Rituximab
Acerta Pharma BV
Phase 3
310
Arizona, California, Georgia, Illinois, Iowa, Kentucky, Minnesota, Nebraska
2017-02-02
Active, closed
Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM)
NCT02899052Multiple Myeloma
DrugsCarfilzomib·Venclexta·Venetoclax·Dexamethasone
AbbVie
Phase 2
120
Alabama, Arkansas, Florida, Georgia, Illinois, Indiana, Kentucky, Maine
2017-01-19
Active, closed
An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib
NCT02955940Pancreatic Cancer, Colorectal Cancer (CRC), Breast Cancer, Lung Cancer
DrugsRegorafenib·Xeloda·Ruxolitinib·Capecitabine
Incyte Corporation
Phase 2
10
California, Kentucky, New York, Tennessee, Texas
2016-11-30
Active, closed
A Study of LY3200882 in Participants With Solid Tumors
NCT02937272Solid Tumor
DrugsNab-paclitaxel·Gemcitabine·Cisplatin
Eli Lilly and Company
Phase 1
223
Kentucky, New York, Texas
2016-11-21
Active, closed
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
NCT02951598Alzheimer Disease, Mild Cognitive Impairment
Eli Lilly and Company
Observational
1,400
California, Colorado, Connecticut, Florida, Georgia, Indiana, Kansas, Kentucky
2016-10-29
Active, closed
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 2
NCT02777593Aortic Aneurysm, Thoracic, Aorta; Lesion
W.L.Gore & Associates
Not applicable
250
California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana, Kentucky
2016-09-06
Recruiting
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
NCT02744677Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration
Edwards Lifesciences
Not applicable
108
Alabama, Arkansas, California, Colorado, Georgia, Kentucky, Massachusetts, Minnesota
2016-07-05
Active, closed
A Study of Acalabrutinib in Combination With Rituximab + (Bendamustine or Venetoclax) in Subjects With MCL
NCT02717624Mantle Cell Lymphoma (MCL)
DrugAcalabrutinib
Acerta Pharma BV
Phase 1
72
Kentucky, Michigan, New Jersey, New York, Ohio, Tennessee, Texas, Washington
2016-04-20
By invitation
A Clinical Registry of Orthobiologics Procedures
NCT03011398Orthopedic Disorder
Regenexx, LLC
Observational
50,000
Arizona, California, Colorado, Florida, Illinois, Iowa, Kentucky, Louisiana
2016-02
Active, closed
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
NCT02542293Non Small Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
953
California, Kentucky, New Jersey, New Mexico, New York, Ohio, Pennsylvania, Texas
2015-11-03
Active, closed
Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer
NCT02516241Urothelial Cancer
DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,126
California, Colorado, Connecticut, Florida, Georgia, Kentucky, Massachusetts, Michigan
2015-11-02
Active, closed
Triathlon Tritanium Cone Augments Outcomes Study
NCT02521103Arthroplasty, Replacement, Knee
Stryker Orthopaedics
Not applicable
254
Florida, Illinois, Kentucky, Michigan, Missouri, New Jersey, Oklahoma, Washington
2015-08
Active, closed
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
NCT02365597Urothelial Cancer
DrugsErdafitinib·Midazolam·Metformin
Janssen Research & Development, LLC
Phase 2
239
Arizona, California, Colorado, District of Columbia, Illinois, Iowa, Kentucky, Minnesota
2015-04-22
Recruiting
C-Brace Prospective Registry
NCT04640584Pareses, Lower Extremity
Otto Bock Healthcare Products GmbH
Observational
250
Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland
2015-04
Active, closed
A Trial of Vigil for Participants With Ovarian Cancer
NCT02346747Ovarian Cancer, Ovarian Neoplasms
Gradalis, Inc.
Phase 2
92
Alabama, California, Florida, Georgia, Kentucky, Maine, Massachusetts, Michigan
2015-02
Active, closed
Study of Acalabrutinib Alone or in Combination Therapy in Subjects With B-cell Non-Hodgkin Lymphoma
NCT02180711Non Hodgkin Lymphoma
DrugsAcalabrutinib·Lenalidomide·Rituximab
Acerta Pharma BV
Phase 1/2
113
Arizona, California, Florida, Illinois, Kentucky, Louisiana, Michigan, New Jersey
2014-12-29
Active, closed
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
NCT02227251Diffuse Large B-cell Lymphoma
DrugSelinexor
Karyopharm Therapeutics Inc
Phase 2
244
Arizona, California, Florida, Illinois, Kentucky, Massachusetts, New Jersey, New York
2014-11
Active, closed
Electrical Nerve Block for Amputation Pain
NCT02221934Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain, Stump Pain
Neuros Medical, Inc.
Not applicable
607
Arizona, Arkansas, Colorado, Florida, Georgia, Illinois, Kentucky, Louisiana
2014-10-09
Active, closed
NOVOCART®3D for Treatment of Articular Cartilage of the Knee
NCT01957722Articular Cartilage of the Femoral Condyle Between 2-6cm2
DrugNOVOCART 3D
Aesculap Biologics, LLC
Phase 3
233
California, Colorado, Florida, Idaho, Illinois, Kentucky, Louisiana, Michigan
2013-12
Active, closed
A Long-term Extension Study of PCI-32765 (Ibrutinib)
NCT01804686Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma
DrugIbrutinib
Janssen Research & Development, LLC
Phase 3
539
California, Connecticut, Georgia, Illinois, Indiana, Kansas, Kentucky, Massachusetts
2013-09-09
Active, closed
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
NCT01480440Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Ununited Humeral Head Fracture
Zimmer Biomet
Observational
200
California, Kentucky, New Jersey, Pennsylvania
2011-01
Active, closed
Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
NCT01526681Peripheral Nerve Injuries
Axogen Corporation
Observational
3,126
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Kansas, Kentucky
2008-11
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Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/kentucky?page=2

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 771 of those studies with a site in Kentucky.

How many clinical trials are recruiting in Kentucky?

371 of the 771 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 10 have not yet opened recruitment, 377 are active but closed to new participants, and 13 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.