Clinical trial register · France

Clinical Trials in Limoges, 2026

Every study on the ClinicalTrials.gov registry that lists a site in France and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 9722 matching records held by the registry are in this view. Synced 29 Oct 2026, 03:20 UTC

9722

Studies in scope

all four open statuses

6047

Recruiting now

open to new participants

1031

Lead sponsors

across recruiting studies

Top sites

Paris 2823 Lyon 1395 Bordeaux 1389 Marseille 1291 Lille 1281

Trials with a site in Limoges

Status

Study

Lead sponsor

Phase

Enrol

Sites in France

Start

Not yet open

Dexmedetomidine for Invasive Ventilation In the NEOnate

NCT07493785Invasive Ventilation, Infant Pain, Infant Discomfort, Infant Neurodevelopment

DrugDexmedetomidine

Centre Hospitalier Intercommunal Creteil

Phase 2/3

246

Brest, Créteil, Grenoble, Lille, Limoges, Nantes, Nice, Paris

2027-01-01

Not yet open

Endoscopic Treatment

NCT07727824Stenoses, Dyspnea

University Hospital, Toulouse

Not applicable

Le Plessis-Robinson, Lille, Limoges, Strasbourg, Suresnes, Toulouse

2027-01

Not yet open

tDCS and Symptom Provocation in Treatment-Resistant OCD

NCT07429500Obsessive - Compulsive Disorder

Centre Hospitalier Henri Laborit

Not applicable

178

Angoulême, Limoges, Nantes, Poitiers, Rennes, Thouars

2026-12-01

Not yet open

Epcoritamab Plus Lenalidomide in Relapsed/Refractory Large B-cell Lymphoma After Second-Line CAR T-cell Therapy

NCT07814001Refractory Diffuse Large B-Cell Lymphoma (DLBCL), Refractory Large B-cell Lymphoma (LBCL), Refractory T-cell/Histiocyte-rich Large B-cell Lymphoma, Refractory Transformed Follicular Lymphoma

DrugsEpcoritamab·Lenalidomide

The Lymphoma Academic Research Organisation

Phase 2

Créteil, Dijon, Lille, Limoges, Lyon, Marseille, Montpellier, Nantes

2026-12

Not yet open

Early Intervention in Remote Autism (IPAAD)

NCT04660669Early Intervention in Remote Autism

University Hospital, Brest

Not applicable

Nantes, Cergy-Pontoise, Le Havre, Limoges

2026-12

Not yet open

Therapeutic Implications of CMR Low Native T1 in Non-treated Non-hypertrophic Females With Fabry Disease (FD)

NCT07872852Fabry Disease

University Hospital, Bordeaux

Not applicable

Bron, Caen, Lille, Limoges, Montpellier, Nîmes, Paris, Pessac

2026-11-01

Not yet open

Efficacy of Sub-laminar and/or Interspinous Tethers to Prevent Proximal Junctional Kyphosis After Surgical Correction of Adult Spinal Deformity

NCT07618897Proximal Junctional Kyphosis

Hospices Civils de Lyon

Not applicable

128

Bordeaux, Limoges, Lyon, Marseille, Paris, Tours

2026-10-22

Not yet open

Evaluation of Efficacy of Coconut Oil Mouth Care for Non-autonomous Hospitalised Elderly People.

NCT07406425Geriatrics, Oral Health Care

University Hospital, Limoges

Not applicable

Brive-la-Gaillarde, Limoges

2026-10-01

Not yet open

MICropsampling for CAffeine in PREMature Newborns

NCT07779915Apnea of Prematurity

University Hospital, Limoges

Not applicable

Brivé, Limoges

2026-10-01

Not yet open

Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)

NCT07871227Colorectal Neoplasms

University Hospital, Bordeaux

Observational

1,200

Angers, Dijon, Limoges, Lyon, Nantes, Nîmes, Paris, Pessac

2026-10

Recruiting

Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test

NCT07859852Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia

Deepull Diagnostics S.L.

Observational

1,500

Limoges, Lyon

2026-09-21

Not yet open

INterest of the Negative Predictive Value of Integrons in the reduCtion of Large Broad-spectrum anTibiotics Consumption for Urinary Tract infectionS

NCT07675018Drug Resistance, Microbial, Biomarkers, Urinary Tract Infections (UTI's), Antibacterial Agents

University Hospital, Limoges

Not applicable

204

Chambray-lès-Tours, La Tronche, Limoges, Paris, Reims

2026-09-15

Not yet open

Superior Mesenteric Artery First Versus Standard Approach in Pancreaticoduodenectomy

NCT07547033Pancreatic Adenocarcinoma, Pancreatic Head Cancer

Assistance Publique - Hôpitaux de Paris

Not applicable

150

Amiens, Angers, Besançon, Bordeaux, Clermont-Ferrand, Dijon, Lille, Limoges

2026-09-01

Not yet open

Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children

NCT07587450Acute Uncomplicated Appendicitis

DrugAmoxi Clavulanate

University Hospital, Toulouse

Phase 3

724

Bordeaux, Grenoble, Lille, Limoges, Marseille, Montpellier, Nantes, Paris

2026-09-01

Not yet open

Real-world Evaluation of Different Endoscopic Biliary Drainage Techniques in Patients With Jaundice of Biliopancreatic Malignant Origin

NCT07817602Biliary Drainage, Endoscopic Ultrasound-Guided Drainage, Pancreatic Cancer

Centre Hospitalier Universitaire de Nīmes

Observational

300

Limoges, Lyon, Montpellier, Nîmes, Paris, Vandœuvre-lès-Nancy

2026-09

Not yet open

Study Evaluating the Efficacy and Safety of the Addition of Ivosidenib to Oral Azacitidine (Onureg®) in Patients Over 55 With Acute Myeloid Leukemia (AML) and IDH1 Mutation, in Complete Remission After Intensive Chemotherapy.

NCT07463768Acute Myeloid Leukemia

DrugsIvosidenib·Azacitidine

French Innovative Leukemia Organisation

Phase 2

Angers, Bayonne, Besançon, Clamart, Créteil, Grenoble, Lille, Limoges

2026-09

Recruiting

ENDometriosis: Evaluation of Detection and Need for ALGOlogic Care Before Surgery

NCT06997809Endometriosis, Pain

University Hospital, Limoges

Not applicable

187

Bordeaux, Le Chesnay, Lille, Limoges, Poissy, Poitiers, Rennes

2026-08-05

Not yet open

Hemodynamic Impact of the Spontaneous Ventilation Test in Patients at Risk of Weaning Pulmonary Oedema

NCT07666880Weaning-induced Pulmonary Edema

University Hospital, Limoges

Not applicable

Boulogne-Billancourt, Limoges, Nice

2026-08-01

Recruiting

Clinical Evaluation of Sensory Neuronopathies: the Neuronoscore Study

NCT07651540Sensory Neuronopathy

Centre Hospitalier Universitaire de Saint Etienne

Not applicable

Angers, Clermont-Ferrand, Grenoble, Lille, Limoges, Lyon, Marseille, Nancy

2026-07-06

Recruiting

Monitor the Evolution of Myasthenia Gravis Symptoms in Real-life in Patients With Anti-AChR and Anti-MUSK Generalised Myasthenia Gravis in Therapy With RYSTIGGO® (Rozanolixizumab)

NCT07570589Generalized Myasthenia Gravis

Centre Hospitalier Universitaire de Nice

Observational

Nice, Angers, Boulogne-sur-Mer, Créteil, Garches, Grenoble, Lille, Limoges

2026-06-15

Not yet open

Complementary and Alternative Medicine Among Patients With Hematologic Malignancies in France

NCT07541326Hematological Malignancies

University Hospital, Limoges

Not applicable

Limoges, Pau

2026-06-15

Not yet open

Liquid Biopsy in Early Colorectal Lesions

NCT07319104Colorectal Neoplasms, Precancerous Conditions, Adenocarcinoma of the Colon

University Hospital, Montpellier

Observational

1,000

Amiens, Bordeaux, Brest, Dijon, Limoges, Lyon, Montpellier, Nancy

2026-06-15

Recruiting

Active Surveillance vs Adjuvant Chemoradiotherapy for Locally Resected Intermediate-Risk T1 Rectal Cancer

NCT07669298Rectal Cancer

Medical University of Gdansk

Not applicable

480

Limoges

2026-06-14

Not yet open

Physical Activity Level at Home in CMT1A Patients: Wearable Sensor Assessment

NCT07591779Charcot-Marie-Tooth Disease, Type IA, Peripheral Neuropathy Hereditary, Motor Activity, Walking, Difficulty

University Hospital, Limoges

Observational

Limoges

2026-06-01

Recruiting

ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia

NCT07245888Ventilator Acquired Pneumonia, Mechanical Ventilation Complication

Region Skane

Observational

400

Limoges

2026-05-01

Recruiting

Radiofrequency Endometrial Ablation or Uterine Artery Embolization for Treatment of Adenomyosis-related Abnormal Uterine Bleeding

NCT07195305Abnormal Uterine Bleeding Due to Adenomyosis (Disorder)

University Hospital, Bordeaux

Not applicable

230

Bordeaux, Clamart, Limoges, Montpellier

2026-04-17

Not yet open

Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.

NCT07527442Posterior Urethral Valves

University Hospital, Bordeaux

Phase 2

Besançon, Bordeaux, Limoges, Marseille, Montpellier, Nantes, Paris, Reims

2026-04-13

Not yet open

Study of Functional Decline and Care Pathways in Neurosurgical Patients Over 65 Years of Age

NCT07506941Ageing and Geriatric Health

University Hospital, Toulouse

Observational

209

Limoges

2026-04-01

Not yet open

Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarkers - A Pilot Study

NCT07479017ALS (Amyotrophic Lateral Sclerosis)

University Hospital, Tours

Observational

Limoges, Lyon, Tours

2026-04

Recruiting

Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.

NCT07299071Colonoscopy, Colorectal Neoplasms, Intestinal Polyps

University Hospital, Bordeaux

Not applicable

592

Bayonne, Brest, Carhaix-Plouguer, Charenton-le-Pont, Limoges, Marseille, Nantes, Nîmes

2026-03-13

Recruiting

Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide

NCT07454837Chronic Hepatitis D

DrugBulevirtide

Mirum Pharmaceuticals, Inc.

Phase 2/3

120

Bordeaux, Clermont-Ferrand, Clichy, Créteil, Grenoble, Lille, Limoges, Lyon

2026-02-26

Recruiting

A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

NCT07318558Ovarian Neoplasms, Ovarian Cancer

DrugsMvasi·Sacituzumab tirumotecan·Avastin·Bevacizumab

Merck Sharp & Dohme LLC

Phase 3

900

Lyon, Strasbourg, Marseille, Plérin, Brest, Toulouse, Limoges, Tours

2026-02-16

Recruiting

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

NCT07215702Sepsis, Acute Kidney Injury

DrugAZD4144

AstraZeneca

Phase 2

124

Angers, Brive-la-Gaillarde, La Roche-sur-Yon, Limoges, Strasbourg, Tours

2026-02-10

Recruiting

A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema

NCT07086339COPD, Emphysema

Pulmair Medical, Inc.

Not applicable

Limoges

2026-02-04

Recruiting

Stratification of Arrhythmic Risk and/or Heart Failure Risk in Patients With Hereditary Heart Disease

NCT07257289Hereditary Heart Diseases

Nantes University Hospital

Observational

1,000

Bordeaux, Brest, Clermont-Ferrand, Dijon, La Rochelle, Limoges, Montpellier, Nantes

2026-02-03

Recruiting

Tucatinib and Trastuzumab in HER3-mutant and HER2-not Amplified Metastatic Breast Cancer

NCT07193394Metastatic Breast Cancer ( HER2 Negative), Unresectable Breast Cancer

DrugsTucatinib·Herceptin·Trastuzumab

Institut Curie

Phase 2

Bordeaux, Limoges, Marseille, Nice, Nîmes, Rennes, Saint-Cloud, Toulouse

2026-01-31

Active, closed

Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis

NCT07332091Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

CSL Behring

Phase 2

Limoges, Marseille, Montpellier, Mulhouse, Pessac, Pierre-Bénite, Rennes, Saint-Brieuc

2026-01-22

Recruiting

B Lymphocyte Populations in the Pulmonary Microenvironment of Patients Under Mechanical Ventilation With or Without VAP (Ventilator-Associated Pneumonia)

NCT07436780Ventilator-associated Pneumonia

University Hospital, Limoges

Observational

Limoges

2026-01-12

Recruiting

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT07222566Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)

DrugsPF-08634404·Pembrolizumab

Pfizer

Phase 3

1,410

Limoges, Angers, Paris, Vandœuvre-lès-Nancy, Villejuif, Boulogne-Billancourt

2026-01-06

Recruiting

Apparent Diffusion Coefficient of the Intervertebral Disc in Children: Pilot Study

NCT07331298Scoliosis Idiopathic

University Hospital, Limoges

Observational

Limoges, Toulouse

2026-01-05

Recruiting

Climate Anxiety in a Young Population at Risk of Suicide

NCT07305688Anxiety, Suicidal Ideation, Mental Health Issue, Environmental Exposure

Centre Hospitalier Esquirol

Observational

108

Limoges

2025-12-15

Recruiting

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

NCT07209111Neoplasm Malignant

DrugsCalderasib·Cetuximab

Merck Sharp & Dohme LLC

Phase 2

150

Limoges, Paris

2025-12-04

Recruiting

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

NCT06937229Alzheimer Disease, Agitation

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

650

Toulouse, Villeurbanne, Lille, Limoges, Montpellier, Paris, Strasbourg

2025-12-02

Recruiting

A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

NCT07218146Small-cell Lung Cancer

DrugZL-1310

Zai Lab (Shanghai) Co., Ltd.

Phase 3

480

Avignon, Bron, Créteil, Le Mans, Limoges, Lyon, Montpellier, Pierre-Bénite

2025-11-30

Recruiting

Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation

NCT07211958Acute Myeloid Leukemias

DrugRevumenib

Syndax Pharmaceuticals

Phase 3

468

Nice, Strasbourg, Marseille, Caen, Rouen, Limoges, Angers, Lille

2025-11-25

Recruiting

A Platform Study in Non-Small Cell Lung Cancer (NSCLC)

NCT06996782Advanced or Metastatic Non-small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Nab-paclitaxel·Pemetrexed

AstraZeneca

Phase 1/2

152

Bordeaux, Dijon, Limoges, Marseille, Nantes, Nice, Paris

2025-11-24

Recruiting

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

NCT07174310Parkinson's Disease

DrugPrasinezumab

Hoffmann-La Roche

Phase 3

900

Marseille, Bron, Clermont-Ferrand, Créteil, La Tronche, Lille, Limoges, Montpellier

2025-11-24

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

NCT07059845Ovarian Cancer

DrugsMirvetuximab Soravtansine·Bevacizumab·Carboplatin

AbbVie

Phase 2

400

Strasbourg, Dijon, Caen, Plérin, Bordeaux, Saint-Cloud, Reims, Limoges

2025-11-13

Active, closed

A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

NCT07170150Alzheimers Disease

DrugTrontinemab

Hoffmann-La Roche

Phase 3

1,060

Amiens Cedex1, Bordeaux, Bron, Limoges, Montpellier, Paris, Saint-Herblain, Strasbourg

2025-11-12

Recruiting

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

NCT07225504Secondary Progressive Multiple Sclerosis (SPMS)

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

1,275

Limoges, Ajaccio, Amiens, Clermont-Ferrand, Grenoble, Lille, Montpellier, Nancy

2025-11-11

Recruiting

Fluid-responsiveness in Children Ventilated With LOW Tidal Volume - The FLOW Study.

NCT07494643Circulatory Failure (Shock)

University Hospital, Bordeaux

Not applicable

Amiens, Bordeaux, Limoges, Paris, Rouen

2025-11-10

Recruiting

TOETVA Technique Compared With Anterior Cervical Thyroidectomy (AC) in Terms of Efficacy and Safety

NCT07055191Lobectomy, Thyroidectomy

University Hospital, Lille

Not applicable

616

Bobigny, Levallois-Perret, Lille, Limoges, Nantes, Paris, Pierre-Bénite, Poitiers

2025-11-07

Not yet open

PErioperative CISGEM + Rilvegostomig in High-Risk Resectable Intra Hepatic CholangioCarcinoma

NCT07128290Intrahepatic Cholangiocarcinoma (Icc)

DrugRilvegostomig

Federation Francophone de Cancerologie Digestive

Phase 2

Caen, Dijon, Grenoble, Limoges, Marseille, Nancy, Nantes, Poitiers

2025-10-30

Recruiting

Esmolol Versus Sufentanil on the Quality of Post-cholecystectomy Recovery Laparoscopic Anaesthesia With Orotracheal Intubation on an Outpatient Basis

NCT07019818Laparoscopic Cholecystectomy Surgery

DrugSufentanil

University Hospital, Limoges

Phase 4

120

Brive-la-Gaillarde, Limoges

2025-10-29

Recruiting

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

NCT07213804Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis

DrugsSofe-M·MIRV·Pegylated liposomal doxorubicin·Topotecan

Eli Lilly and Company

Phase 3

1,630

Angers, Bayonne, Besançon, Bordeaux, Brest, Lille, Limoges, Lyon Cedex08

2025-10-22

Recruiting

Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement?

NCT06643845Osteoarthritis, Knee

University Hospital, Brest

Not applicable

1,000

Amiens, Brest, Caen, La Roche-sur-Yon, Le Mans, Limoges, Lomme, Lyon

2025-10-17

Recruiting

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

NCT07165028Metabolic Dysfunction-Associated Steatotic Liver Disease

DrugsRetatrutide·Tirzepatide

Eli Lilly and Company

Phase 3

4,500

Amiens, Angers, Besançon, Clichy, Dijon, La Roche-sur-Yon, Lille, Limoges

2025-10-15

Recruiting

Integrating AI in Stroke Neurorehabilitation

NCT07138495Stroke

Eodyne Systems SL

Not applicable

192

Limoges

2025-10-15

Recruiting

Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders

NCT07237009Neurocognitive Disorders, Mild, Cognitive Impairment, Mild, Depression Mild, Apathy

KompanionCare SAS

Observational

Angers, Limoges, Nice, Paris, Tours

2025-10-14

Recruiting

StrAtegies For Zoledronic Acid Post-dEnosumab Discontinuation in Postmenopausal oSTeoporosis

NCT06767150Postmenopausal Osteoporosis

University Hospital, Toulouse

Phase 4

200

Amiens, Bordeaux, Cahors, Dax, Le Mans, Lille, Limoges, Marseille

2025-10-02

Not yet open

Health-economic Evaluation of the IPS (Individual Placement and Support) Model for Helping People With Severe Mental Disorders Access Employment in the Ordinary Labor Market, Compared to Standard Methods of Helping People Return to Work: a Prospective Real-life Study

NCT07206316Severe Mental Disorders

University Hospital, Tours

Observational

234

Angers, Bourges, Bron, Clermont, Clermont-Ferrand, La Rochelle, Limoges, Montpellier

2025-10-02

Recruiting

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

NCT07196748Colitis, Ulcerative

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

882

Bayonne, Clermont-Ferrand, Créteil, Échirolles, Lille, Limoges, Montfermeil, Montpellier

2025-10-01

Not yet open

In Situ Injection of Anti-angiogenics in Patients With Brain Arteriovenous Malformations Not Eligible for Exclusion Treatment

NCT07075757Brain Arteriovenous Malformations

Assistance Publique - Hôpitaux de Paris

Phase 1

Limoges, Nancy, Paris, Rouen

2025-10-01

Recruiting

Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients

NCT06910891Sepsis, Emergency Care, Microcirculation

University Hospital, Limoges

Not applicable

556

Brivé, Guéret, Limoges, Saint-Junien, Tulle, Ussel

2025-09-20

Recruiting

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

NCT07023835Amyotrophic Lateral Sclerosis (ALS)

Zydus Therapeutics Inc.

Phase 2

240

Clermont-Ferrand, Limoges, Montpellier, Nice, Paris, Tours

2025-09-17

Not yet open

Modeling Clinical Outcomes in Gambling Addiction

NCT06981546Gambling Disorder

Hospices Civils de Lyon

Observational

268

Besançon, Bron, Clermont-Ferrand, Lille, Limoges, Nîmes, Paris, Saint-Etienne

2025-09-01

Recruiting

A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)

NCT07200908Chronic Hepatitis D Infection

DrugBulevirtide

Mirum Pharmaceuticals, Inc.

Phase 3

172

Clermont-Ferrand, Clichy, Créteil, La Tronche, Le Chesnay, Lille, Limoges, Lyon

2025-08-27

Recruiting

A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer

NCT06868485Non Small Cell Lung Cancer

DrugWSD0922-FU

Wayshine Biopharm, Inc.

Phase 2

Rennes, Limoges, Pessac, Caen, Toulon

2025-08-18

Recruiting

Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation

NCT06853886Chronic Hepatitis B Virus

University Hospital, Limoges

Not applicable

140

Limoges, Lyon

2025-08-12

Active, closed

A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection

NCT07142811Viral Hepatitis

DrugsElebsiran·Tobevibart·Bulevirtide

Vir Biotechnology, Inc.

Phase 2

100

Clichy, Créteil, Limoges, Rennes, Toulouse

2025-08-05

Active, closed

A Study to Evaluate Tobevibart+Elebsiran in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide

NCT07128550Viral Hepatitis

DrugsElebsiran·Tobevibart·Bulevirtide

Vir Biotechnology, Inc.

Phase 3

150

Bobigny, Clichy, Créteil, Le Chesnay, Limoges, Lyon, Montpellier, Pessac

2025-07-30

Active, closed

Impact of CErebral Endovascular PROcedures on the Systemic Immune responSe Response

NCT05621850Cerebral Arterio-venous Malformation

University Hospital, Limoges

Not applicable

Limoges

2025-07-25

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

NCT07011745Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

426

Toulouse, Villeurbanne, Lille, Limoges, Montpellier, Paris, Strasbourg

2025-07-16

Recruiting

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

NCT06997497Colon Adenocarcinoma, Rectal Adenocarcinoma

DrugsLeucovorin/levofolinate calcium·Bevacizumab biosimilar·Calderasib·Mvasi

Merck Sharp & Dohme LLC

Phase 3

477

Nice, Caen, Toulouse, Limoges, Vandœuvre-lès-Nancy, Reims, Angers, Rouen

2025-07-16

Recruiting

A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy

NCT06963827Kidney Disease

DrugMezagitamab

Takeda

Phase 3

347

Créteil, Bordeaux, Limoges, Montpellier, Nantes, Paris

2025-07-15

Active, closed

A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

NCT06963710Chronic Hepatitis B Infection

DrugALG-000184

Aligos Therapeutics

Phase 2

200

Clichy, Limoges, Nice, Toulouse

2025-07-15

Recruiting

A Phase 1b/2a Trial to Evaluate Invobenitug Also Known as Procizumab (PCZ; AK1967) in Critical Cardiovascular Care.

NCT06832722Shock, Cardiogenic

4TEEN4 Pharmaceuticals GmbH

Phase 1/2

Bobigny, Dijon, Lille, Limoges, Nancy, Paris

2025-07-13

Recruiting

Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus

NCT07004699Oxygen Inhalation Therapy Endoscopy

Poitiers University Hospital

Not applicable

610

La Roche-sur-Yon, Limoges, Poitiers

2025-07-11

Active, closed

A Phase II Trial of Teclistamab in Participants With Previously Treated Immunoglobulin Light-chain (AL) Amyloidosis

NCT06649695AL Amyloidosis

DrugTeclistamab

European Myeloma Network B.V.

Phase 2

Limoges

2025-07-02

Recruiting

Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome

NCT06889974Renal Replacement Therapy for Acute Kidney Injury in ICU

University Hospital, Bordeaux

Observational

800

Angers, Bordeaux, Brest, Limoges, Nantes, Orléans, Pau, Rennes

2025-07-01

Not yet open

Exploratory Study of Sensory Profile and Coping Strategies in Eating Disorders

NCT07031037Eating Disorders, Anorexia Nervosa, Boulimia Nervosa, Hyperphagia

Centre Hospitalier Esquirol

Observational

150

Limoges

2025-07

Recruiting

Identification and Characterisation of IgA With Nephritogenic Potential in IgA Deposition Nephropathies (Rep-IgAN)

NCT07295808Kidney Disease

University Hospital, Limoges

Not applicable

150

Limoges

2025-06-25

Recruiting

NEUROvascular NAVigation With Remotely Controlled Deflectable Guidewire, Study I (NeuroNAV Study I)

NCT06972953Unruptured Cerebral Aneurysm

Artiria Medical

Not applicable

Limoges

2025-06-16

Recruiting

JAK Inhibitor Dose TAPering Strategy Study

NCT06687551Rheumatoid Arthritis (RA

DrugsFilgotinib·Tofacitinib·Upadacitinib

University Hospital, Toulouse

Phase 4

308

Toulouse, Amiens, Bordeaux, Brest, Clermont-Ferrand, Le Mans, Lille, Limoges

2025-06-06

Recruiting

Acceptability and Feasibility of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users and Vulnerable Populations, in Non-conventional Structures "Outside the Walls" by Dual Screening Method RTDs and FibroScan®

NCT06904820Viral Hepatitis

University Hospital, Limoges

Observational

2,300

Limoges

2025-06-05

Recruiting

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

NCT07000357Cardiovascular Disease

DrugAZD0780

AstraZeneca

Phase 3

15,100

Bordeaux, Brest, Bron, Corbeil-Essonnes, Dijon, La Tronche, Lille, Limoges

2025-06-04

Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

NCT06925737Prostate Cancer, Prostatic Neoplasms

DrugsIfinatamab Deruxtecan·Prednisolone·Prednisone·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

1,440

Suresnes, Strasbourg, Marseille, Caen, Besançon, Nîmes, Limoges, Vandœuvre-lès-Nancy

2025-05-13

Recruiting

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

NCT06819891Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

425

Pierre-Bénite, Chambray-lès-Tours, Clermont-Ferrand, Créteil, La Roche-sur-Yon, Lille, Limoges, Montpellier

2025-05-12

Recruiting

Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY)

NCT06354179Liver Transplantation, Immunosuppression

DrugTacrolimus

University Hospital, Limoges

Phase 4

162

Besançon, Clichy, Dijon, Grenoble, Lille, Limoges, Lyon, Marseille

2025-04-15

Active, closed

Validation of the French Version of the Primary Lateral Sclerosis Functioning Rating Scale (PLSFRS)

NCT06878235Lateral Sclerosis

University Hospital, Tours

Observational

Brest, Clermont-Ferrand, Lille, Limoges, Lyon, Nice, Tours

2025-04-11

Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

NCT06868277Carcinoma, Non-Small Cell Lung

DrugsRilvegostomig·Keytruda·Pembrolizumab

AstraZeneca

Phase 3

830

Angers, Avignon, Boulogne-Billancourt, Caen, Chambéry, Dijon, La Tronche, Limoges

2025-04-10

Recruiting

Evaluation of Software for Interpreting Virological Results Indicated for the Diagnosis of Cytomegalovirus (CMV) Infection During Pregnancy and Intended for Health Professionals

NCT06694428Cytomegalovirus Infections, Maternal Primary Cytomegalovirus Infection

Assistance Publique - Hôpitaux de Paris

Observational

491

Limoges, Paris, Villejuif

2025-04-04

Recruiting

Sensory Profile of People With High Intellectual Potential (HIP)

NCT07072455High Intellectual Potential

Centre Hospitalier Esquirol

Observational

160

Limoges

2025-04-01

Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT06841354Triple Negative Breast Neoplasms

DrugsAbraxane·Sacituzumab tirumotecan·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,000

Lyon, Limoges, Montpellier, Saint-Herblain, Reims, Rouen, Toulon, Paris

2025-03-16

Recruiting

A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy

NCT06854640Sepsis, Coagulopathy

DrugBAY3389934

Bayer

Phase 1

Tours, Strasbourg, Limoges, Angers, La Roche-sur-Yon, Nantes, Garches

2025-03-12

Recruiting

PMCF Registry to Describe the Safety and Performance of p64, p48 MW and p64 MW in France

NCT07748572Intracranial Aneurysms

Phenox GmbH

Observational

200

Amiens, Bordeaux, Bron, Clermont-Ferrand, Le Kremlin-Bicêtre, Limoges, Paris, Reims

2025-03-07

Not yet open

Systemic Antitumor Treatment with or Without Pressurized Intraperitoneal Aerosol Chemotherapy for Colon Peritoneal Metastases (PIPOX02)

NCT06681038Peritoneal Metastases from Colorectal Cancer

Institut Cancerologie de l'Ouest

Phase 2

114

Caen, Dijon, Lille, Limoges, Marseille, Montpellier, Paris, Pierre-Bénite

2025-02

Not yet open

Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease.

NCT06754553Parkinson Disease

University Hospital, Strasbourg, France

Observational

100

Besançon, Bron, Clermont-Ferrand, Créteil, Grenoble, Lille, Limoges, Marseille

2025-02

Recruiting

Interest of Post-operative Chemotherapy in Patients With Localised Uterine Leiomyosarcoma Suspected of Having a High Risk of Recurrence Based on a Biological Test Performed on the Tumour

NCT06524583Leiomyosarcoma Uterus

DrugsTrabectedin·Doxorubicin

UNICANCER

Phase 2

198

Angers, Besançon, Bordeaux, Caen, Clermont-Ferrand, Dijon, Limoges, Lyon

2025-01-27

Recruiting

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

NCT06717347Diffuse Large B-Cell Lymphoma

DrugsRituximab Biosimilar·Zilovertamab vedotin·Riabni·Ruxience

Merck Sharp & Dohme LLC

Phase 3

1,046

Nice, La Rochelle, Dijon, La Tronche, Limoges, Metz, Dunkirk, Clermont-Ferrand

2025-01-27

Recruiting

Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).

NCT06641414Higher-risk Myelodysplastic Syndrome

DrugsLisaftoclax·Azacitidine

Ascentage Pharma Group Inc.

Phase 3

490

Angers, Le Mans, Limoges, Nantes, Nice, Orléans, Paris, Pessac

2025-01-22

Recruiting

Detection of Homologous Recombination Pathway Gene Mutations in Circulating Tumour DNA From BRCA-mutated Ovarian Cancer Patients Receiving First-line PARP Inhibitor Maintenance Therapy

NCT06588322Ovarian Cancer

Institut Claudius Regaud

Not applicable

130

Angers, Bordeaux, Limoges, Nîmes, Saint-Herblain, Toulouse

2025-01-08

Recruiting

Speech Perception of a Tonotopy-based Fitting for Cochlear Implant Recipients for 6 Months With Conventional Setting

NCT06723262Sensorineural Hearing Loss, Bilateral

MED-EL Elektromedizinische Geräte GmbH

Not applicable

Limoges

2025-01-01

Recruiting

Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery Versus or Laparoscopic Hysterectomy

NCT05884658Hysterectomy, Vaginal

Centre Hospitalier Universitaire de Saint Etienne

Not applicable

200

Bron, Clermont-Ferrand, Issoire, Limoges, Saint-Etienne

2024-12-23

Active, closed

A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy

NCT06742190Multifocal Motor Neuropathy (MMN), MMN

DrugsEmpasiprubart·Immunoglobulin·IVIG

argenx

Phase 3

154

Bordeaux, Brest, Bron, Le Kremlin-Bicêtre, Lille, Limoges, Marseille, Nice

2024-12-18

Recruiting

Albumin Modifications as Early Biomarkers of Chronic Liver Diseases

NCT06318949Chronic Liver Disease

University Hospital, Limoges

Not applicable

756

Angers, Limoges, Poitiers, Rennes, Toulouse, Tours

2024-12-09

Recruiting

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.

NCT06382948Advanced Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, ESR1 Gene Mutation

DrugsElacestrant·Everolimus

MedSIR

Phase 3

300

Bordeau, Bordeaux, Dijon, Limoges, Lyon, Marseille, Paris, Plérin

2024-12-05

Recruiting

MEN1703 (SEL24) to Treat Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma (JASPIS-01)

NCT06534437Non-Hodgkin Lymphoma, B-cell

DrugGlofitamab

Ryvu Therapeutics SA

Phase 2

178

Le Mans, Lille, Limoges, Lyon, Montpellier, Paris, Pessac

2024-12-05

Active, closed

Prospective Cohort Study of a Population at Risk of Psychotic Transition

NCT06539611At-risk Mental States

Centre Hospitalier Esquirol

Observational

125

Limoges

2024-11-18

Recruiting

Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI

NCT06486467Velocity-time Integral Measurement, Critically Ill Patients, Tissue Hypoperfusion

Assistance Publique - Hôpitaux de Paris

Not applicable

100

Limoges, Paris

2024-11-14

Active, closed

Study To Assess Effectiveness and Adverse Events of Foscarbidopa/ Foslevodopa in Adult Participants With Advanced Parkinson Disease in Real Life Setting

NCT06639620Advanced Parkinson Disease

AbbVie

Observational

250

Strasbourg, Clermont-Ferrand, Lyon, Marseille, Saint-Brieuc, Besançon, Brest, Limoges

2024-11-12

Active, closed

A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)

NCT06537414Chronic Hepatitis B Virus Infection, Hepatitis B

DrugBepirovirsen

GlaxoSmithKline

Phase 2

283

Clichy, Créteil, Limoges, Lyon, Marseille

2024-11-11

Recruiting

EkiYou-Study-2 : A National Multicentric Trial of the EkiYou Application for Insulin Bolus Calculation

NCT06738849Diabetes Type 1, Diabetes Type 2 on Insulin, Pancreatogenous Diabetes

DiappyMed

Not applicable

154

Bobigny, Caen, Chartres, Corbeil-Essonnes, Dijon, Le Havre, Limoges, Marseille

2024-11-05

Recruiting

Epidemiological Data on Mast Cell Pathologies in France

NCT06186856Mast Cell Disorder

Imagine Institute

Observational

13,000

Amiens, Angers, Besançon, Caen, Clermont-Ferrand, Grenoble, Lille, Limoges

2024-11-01

Recruiting

Comparison of Vedolizumab Treatment to Adalimumab Dose Intensification in Crohn's Disease Patients With Loss of Response or Biomarker Activity to Adalimumab on First Line With Therapeutic Drug Concentration.

NCT06180382Crohn's Disease

DrugsVedolizumab·Adalimumab

Centre Hospitalier Universitaire de Saint Etienne

Phase 4

220

Le Kremlin-Bicêtre, Amiens, Lille, Limoges, Marseille, Montpellier, Nice, Paris

2024-10-31

Active, closed

Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinomas

NCT06557889Squamous Cell Carcinoma of Head and Neck

DrugsCisplatin/Carboplatin·Adrucil·Pembrolizumab

Institut Claudius Regaud

Phase 2

Amiens, Avignon, Bordeaux, Clermont-Ferrand, Limoges, Marseille, Nantes, Nice

2024-10-21

Recruiting

Effectiveness of the WHO ICOPE (Integrated Care for Older People) Program in Preventing Age-related Functional Decline (ICOPE Trial.Fr)

NCT06676839Ageing

University Hospital, Toulouse

Not applicable

1,000

Castres, Perpignan, Tarbes, Toulouse, Angers, Limoges

2024-10-14

Recruiting

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

NCT06528314NASH - Nonalcoholic Steatohepatitis, MASH - Metabolic Dysfunction-Associated Steatohepatitis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

2,150

Strasbourg, Pessac, Limoges, Lille, Clichy, Vandœuvre-lès-Nancy, Angers, Toulouse

2024-10-04

Recruiting

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

NCT06492616Breast Cancer

DrugsElacestrant·Tamoxifen·Exemestane·Anastrozole

Stemline Therapeutics, Inc.

Phase 3

4,220

Besançon, Nice, Strasbourg, Grenoble, Valenciennes, Montpellier, Chambray-lès-Tours, Limoges

2024-09-27

Recruiting

Medico-economic Evaluation of Robot-assisted Laparoscopy Compared With Conventional Laparoscopy in Hysterectomy for Endometrial Cancer.

NCT06348719Hysterectomies for Low- or Intermediate-risk Endometrial Carcinoma

Rennes University Hospital

Not applicable

1,680

Lille, Limoges, Paris, Pierre-Bénite, Plérin, Rennes, Rouen, Saint-Etienne

2024-09-23

Recruiting

French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis

NCT06147843Amyotrophic Lateral Sclerosis

University Hospital, Limoges

Not applicable

1,000

Lille, Limoges, Marseille, Montpellier, Nice, Paris, Tours

2024-09-17

Active, closed

A Study to Compare ABP 234 and Keytruda® (Pembrolizumab) in Participants With Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer

NCT06311721Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer

DrugsABP 234·Keytruda·Pembrolizumab

Amgen

Phase 3

315

Bordeaux, Limoges, Marseille, Montpellier, Nîmes, Toulon, Valenciennes, Vantoux

2024-09-09

Recruiting

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

NCT06452277Advanced Non-small Cell Lung Cancer, HER2 Mutation

DrugsSevabertinib·Pemetrexed·Cisplatin·Carboplatin

Bayer

Phase 3

444

La Tronche, Pierre-Bénite, Brest, Mulhouse, Lille, Bordeaux, Limoges, Rouen

2024-08-28

Recruiting

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

NCT06216301Metastatic Non-small Cell Lung Cancer

DrugPembrolizumab

NovoCure GmbH

Phase 3

734

Créteil, Limoges, Marseille, Nantes, Paris, Pessac, Pierre-Bénite, Strasbourg

2024-07-31

Active, closed

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

NCT06517758Generalized Myasthenia Gravis

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

146

Limoges, Garches, Nice, Paris

2024-07-31

Recruiting

Hydroxychloroquine as a Steroid-sparing Agent in Extrapulmonary Sarcoidosis

NCT05841758Sarcoidosis, Pulmonary

DrugHydroxychloroquine

Hospices Civils de Lyon

Phase 4

140

Avignon, Bobigny, Créteil, Dijon, Lille, Limoges, Lyon, Montpellier

2024-07-30

Recruiting

Effects of the COTID (Community Occupational Therapist in Dementia) Program and Usual Occupational Therapy Care on Recurrence of Falls at 12 Months in Elderly People With Neurocognitive Disorders Who Had Been Hospitalized for Falls, After Their Return Home

NCT06237218Nervous System Diseases

University Hospital, Limoges

Not applicable

Limoges

2024-07-29

Active, closed

A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery

NCT06161441Resectable Non-small Cell Lung Cancer

DrugsFianlimab·Cemiplimab·Platinol·Paraplatin

Regeneron Pharmaceuticals

Phase 2

195

Nancy, Saint-Herblain, Bordeaux, Limoges, Boulogne-Billancourt, Dijon, Nantes, Vantoux

2024-07-16

Active, closed

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

NCT06456346Essential Thrombocythemia

DrugsBomedemstat·Hydroxyurea

Merck Sharp & Dohme LLC

Phase 3

300

Nice, Pessac, Marseille, Toulouse, Limoges, Tours, Nantes, Pierre-Bénite

2024-07-16

Active, closed

Minimal Residual Disease-based Strategy With T-Cell Redirector After Treatment With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (D-VRd) in Newly Diagnosed Multiple Myeloma

NCT06353022Multiple Myeloma

DrugsTalquetamab·Teclistamab·Bortezomib·Daratumumab

Nantes University Hospital

Phase 2

103

Bayonne, Caen, Dijon, La Roche-sur-Yon, Lille, Limoges, Lyon, Marseille

2024-06-26

Recruiting

Randomized Phase III Trial Testing Maintenance Olaparib Versus Observation After Adjuvant Chemoradiation for p53abn Endometrial Cancer

NCT06712472Endometrial Cancer, p53abn

DrugOlaparib

Gustave Roussy, Cancer Campus, Grand Paris

Phase 3

554

Albi, Angers, Besançon, Carcassonne, Dijon, Grenoble, Limoges, Lyon

2024-06-26

Active, closed

A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)

NCT06472076Lung Cancer, Non-Small Cell

DrugsBelrestotug·Dostarlimab·Pembrolizumab

GlaxoSmithKline

Phase 3

Angers, Boulogne-Billancourt, Limoges, Lorient, Pessac, Rennes

2024-06-10

Recruiting

ECLECTIC: EstroTEP and Circulating Biomarkers for ER-positive HER2-negative Metastatic Breast Cancer Patients

NCT06195709Breast Carcinoma

Institut Curie

Phase 3

300

Bayonne, Bordeaux, Caen, Dijon, Lille, Limoges, Lyon, Marseille

2024-05-27

Recruiting

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

NCT06419374Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis

DrugPegozafermin

Hoffmann-La Roche

Phase 3

1,800

Amiens, Clichy, Dijon, Limoges, Lyon, Montpellier, Nice, Paris

2024-05-24

Recruiting

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

NCT06203210Small Cell Lung Cancer

DrugsAmrubicin·Ifinatamab Deruxtecan·Lurbinectedin·Topotecan

Daiichi Sankyo

Phase 3

540

Avignon, Bordeaux, Créteil, Lille, Limoges, Lyon, Marseille, Montpellier

2024-05-21

Recruiting

Trial Evaluating the Rate of Pneumothorax in Severe Emphysema Secondary to Endoscopic Volume Reduction With Two-stage ZEPHYR® Valves Versus Endoscopic Volume Reduction With One-stage ZEPHYR® Valves

NCT06181357COPD

University Hospital, Limoges

Not applicable

244

Bordeaux, Brest, Bron, Dijon, Grenoble, Lille, Limoges, Marseille

2024-05-06

Not yet open

Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw

NCT06419010Osteonecrosis of the Jaw

University Hospital, Toulouse

Not applicable

150

Bordeaux, Limoges, Montpellier, Paris, Toulouse

2024-05

Recruiting

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)

NCT05485961End Stage Kidney Disease

DrugClazakizumab

CSL Behring

Phase 2/3

3,110

Amiens, Aura, Brest, Caen, Compiègne, Grabels, Lille, Limoges

2024-04-27

Recruiting

A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer

NCT06319820Non-Muscle Invasive Bladder Neoplasms

DrugGemcitabine

Janssen Research & Development, LLC

Phase 3

641

Lille, Limoges, Lyon, Marseille, Paris, Quint-Fonsegrives, Rennes, Toulouse

2024-04-18

Recruiting

Efficacy of Inhaled Aromatherapy on Nausea and Vomiting in Hematological Malignancies

NCT06150469Hematological Malignancies

University Hospital, Limoges

Not applicable

286

Brivé, La Réunion, Limoges, Saint-Germain-en-Laye

2024-04-17

Recruiting

Clinical Relevance of Detecting Molecular Abnormalities in Glial Tumor Exosomes

NCT06116903Glioma

University Hospital, Limoges

Not applicable

Limoges

2024-04-11

Active, closed

A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)

NCT06211764Non-Muscle Invasive Bladder Neoplasms

DrugsTAR-200·Mitomycin C·Gemcitabine

Janssen Research & Development, LLC

Phase 3

272

Lille, Limoges, Marseille, Paris, Quint-Fonsegrives, Rennes, Suresnes

2024-04-09

Recruiting

Study of the Prevalence of Sexual Dysfunction in Women After Rectal Cancer Surgery and Analysis of the Impact of a Sexologist Intervention

NCT05933122Rectal Tumor, Women, Sexuality, Life Quality

University Hospital, Limoges

Not applicable

144

Brive-la-Gaillarde, Guéret, Limoges, Saint-Junien

2024-04-03

Recruiting

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

NCT06312137Non Small Cell Lung Cancer

DrugsSacituzumab tirumotecan·Pemetrexed·Gemcitabine·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

780

Brest, Toulouse, Rouen, Limoges, Valenciennes, Clermont-Ferrand, Bron, Toulon

2024-04-03

Recruiting

Impact of Psychomotor Therapy on the Quality of Life in Depression

NCT06234176Major Depressive Disorder

Centre Hospitalier Esquirol

Not applicable

128

Limoges

2024-04-01

Recruiting

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion

NCT06158854Immunoglobulin Light Chain (AL) Amyloidosis

DrugEtentamig

AbbVie

Phase 1/2

Limoges, Toulouse

2024-04-01

Recruiting

Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy

NCT05952167Radiculopathy, Cervical

Centre Hospitalier Departemental Vendee

Not applicable

206

La Roche-sur-Yon, La Rochelle, Le Puy-en-Velay, Limoges, Nantes, Paris, Reims, Rouen

2024-03-25

Recruiting

Evaluation of Treatment by Glofitamab in Combination With Rituximab or Obinutuzumab Plus CHOP in Patients With RIchter Syndrome

NCT06186648Richter Syndrome

DrugsGlofitamab·Obinutuzumab

French Innovative Leukemia Organisation

Phase 2

Amiens, Angers, Bayonne, Clermont-Ferrand, Grenoble, Lille, Limoges, Lyon

2024-03-21

Recruiting

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

NCT06318169Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis

DrugPegozafermin

Hoffmann-La Roche

Phase 3

1,350

Amiens, Angers, Bordeaux, Clichy, Lille, Limoges, Lyon, Montpellier

2024-03-13

Active, closed

Asciminib Prospective Non Interventional Study as 3rd Line Therapy or More to Treat Adult Patients With CML- CP in Real World Setting in France

NCT06092879Chronic Myeloid Leukemia

Novartis Pharmaceuticals

Observational

201

Angers, Limoges, Saint Priest Jarez, Aix-en-Provence, Amiens, Antibes, Avignon, Besançon

2024-03-06

Recruiting

The PENTO Protocol in Medication-related Osteonecrosis of the Jaw

NCT05795647Medication-related Osteonecrosis of the Jaw (MRONJ)

DrugsTocopherol·Pentoxifylline

University Hospital, Limoges

Phase 2

Limoges

2024-02-29

Recruiting

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

NCT06035120Emphysema, Pulmonary, Emphysema or COPD

Pulmonx Corporation

Not applicable

200

Limoges, Paris, Strasbourg, Toulouse

2024-02-22

Recruiting

A Long-term Observational Study Evaluating the Presentation and Management of Acute Respiratory Tract Infections in Primary Care Across Europe

NCT06282718Acute Respiratory Tract Infection

European Clinical Research Alliance for Infectious Diseases (ECRAID)

Observational

2,000

Limoges

2024-02-22

Recruiting

Radiofrequency Ablation vs Doppler-guided Haemorrhoidal Artery Ligation in the Treatment of Haemorrhoidal Disease

NCT06170736Haemorrhoids, Internal Haemorrhoids, Grade II/III Haemorrhoids

Centre Hospitalier Departemental Vendee

Not applicable

168

Amiens, Angers, Bordeaux, Brest, Écully, La Roche-sur-Yon, Lille, Limoges

2024-02-21

Recruiting

Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in Patients Treated for Localized Breast Cancer

NCT06027632Breast Cancer, Cognitive Dysfunction

Centre Francois Baclesse

Not applicable

300

Bordeaux, Briis-sous-Forges, Caen, Chambéry, Clermont-Ferrand, Dijon, Grenoble, Limoges

2024-02-09

Active, closed

A Study About Antibody Levels and Biomarkers in the Blood in People With Late-onset Pompe Disease

NCT06150820Pompe Disease (Late-onset)

Astellas Gene Therapies

Not applicable

119

Angers, Garches, Lille, Limoges, Marseille, Nantes, Nice, Strasbourg

2024-02-01

Active, closed

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

NCT06208150Multiple Myeloma

DrugsElotuzumab·Talquetamab·Velcade·Teclistamab

Janssen Research & Development, LLC

Phase 3

838

Lille, Limoges, Lyon, Marseille, Nantes, Paris, Pessac, Strasbourg

2024-01-22

Recruiting

DELTA DESCRIBE: the French Collaborative Project

NCT05936073Hepatitis D

University Hospital, Limoges

Observational

734

Limoges

2024-01-22

Active, closed

A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)

NCT06018337Metastatic Breast Cancer

DrugsDB-1303/BNT323·Nab-paclitaxel·Capecitabine·Paclitaxel

DualityBio Inc.

Phase 3

541

Marseille, La Rochelle, Besançon, Nîmes, Bordeaux, Toulouse, Limoges, Montpellier

2024-01-18

Recruiting

Study Investigating the Efficacy and Safety of the Addition of Oral-azacitidine to Salvage Treatment by Gilteritinib in Subjects ≥18 Years of Age With Relapsed/Refractory FLT3-mutated Acute Myeloid Leukemia

NCT06022003AML, Adult, Refractory AML, Relapsed Adult AML, FLT3-TKD Mutation

DrugsOnureg·Xospata·Gilteritinib·Azacitidine

French Innovative Leukemia Organisation

Phase 2

Amiens, Angers, Clamart, Clermont-Ferrand, Créteil, Grenoble, Lille, Limoges

2024-01-13

Active, closed

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

NCT06079879Essential Thrombocythemia

DrugsAnagrelide·Bomedemstat·Busulfan·Ruxolitinib

Merck Sharp & Dohme LLC

Phase 3

340

Rennes, Tours, Limoges, Vandœuvre-lès-Nancy, Roubaix, Pierre-Bénite, Paris

2023-12-31

Active, closed

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)

NCT06099782Non-Small Cell Lung Cancer, Renal Cell Carcinoma, Melanoma

Drugs) Berahyaluronidase alfa·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 2

147

Lyon Cedex08, Caen, Limoges, Toulon, Paris

2023-12-26

Recruiting

PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer

NCT05581121Cervical Carcinoma, Adenocarcinoma, Adenosquamous Carcinoma

Institut Claudius Regaud

Phase 3

510

Angers, Bordeaux, Brest, Caen, Créteil, Dijon, Lille, Limoges

2023-12-20

Recruiting

Sensory Profile and Early Clinical Signs of Calm Room Users

NCT06839950Psychotic Disorders, Personality Disorders, Mood Disorders

Centre Hospitalier Esquirol

Observational

Limoges

2023-12-19

Active, closed

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)

NCT05973773Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation

DrugZipalertinib

Taiho Oncology, Inc.

Phase 3

285

Strasbourg, Caen, Limoges, Pessac, Le Mans, Villejuif, Quimper, Boulogne-Billancourt

2023-12-18

Recruiting

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

NCT06170788Non-small Cell Lung Cancer (NSCLC)

DrugsSacituzumab tirumotecan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

614

Marseille, Montpellier, Limoges, Nancy, Bayonne, Villefranche-sur-Saône, Amiens, Poitiers

2023-12-15

Recruiting

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NCT06215716NASH With Fibrosis, MASH With Fibrosis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

1,650

Nice, Lyon, Strasbourg, Limoges, Clichy, Vandœuvre-lès-Nancy, Angers, Toulouse

2023-12-01

Active, closed

A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy

NCT05988073Multifocal Motor Neuropathy

argenx

Observational

413

Angers, Bordeaux, Brest, Bron, Le Kremlin-Bicêtre, Lille, Limoges, Marseille

2023-11-29

Recruiting

A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa.

NCT06022159Soft Tissue Sarcoma

Institut Claudius Regaud

Phase 2

Bordeaux, Lille, Limoges, Lyon, Montpellier, Paris, Poitiers, Saint-Herblain

2023-11-28

Recruiting

Tolerance Study of Robotic-Assisted Virtual Reality Walking Rehabilitation for Non-Walking Stroke Patients

NCT06053619Stroke, Central Nervous System Diseases

University Hospital, Limoges

Not applicable

Limoges

2023-11-20

Recruiting

Study of Families With an Hemopathies Predisposition Related to the DDX41 Gene.

NCT06022016DDX41 Gene Mutation

Institut Claudius Regaud

Not applicable

910

Bordeaux, Limoges, Marseille, Montpellier, Toulouse

2023-11-17

Recruiting

ACP-204 in Adults With Alzheimer's Disease Psychosis

NCT06159673Alzheimer's Disease Psychosis

DrugACP-204

ACADIA Pharmaceuticals Inc.

Phase 2/3

1,074

Bron, Colmar, Dijon, Limoges, Lyon, Paris, Rouen, Toulouse

2023-11-14

Active, closed

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

NCT06112379Breast Cancer

DrugsDato-DXd·Epirubicin·Xeloda·Olaparib

AstraZeneca

Phase 3

1,902

Avignon, Bayonne, Caen, Clermont-Ferrand, Limoges, Marseille, Montpellier, Nice

2023-11-14

Active, closed

Impact of Annual Versus Biannual Infusions of Ocrelizumab in Patients With Active MS,After 2 Years of Initial Treatment, on Freedom From Radiological Disease Activity at Two Years: a Multicenter Randomized Controlled Non-inferiority Trial

NCT05999604Multiple Sclerosis

DrugOcrelizumab

Fondation Ophtalmologique Adolphe de Rothschild

Phase 3

244

Créteil, Gonesse, Grenoble, Limoges, Lyon, Nice, Paris, Poissy

2023-11-09

Recruiting

Oral Pooled Fecal Microbiotherapy to Prevent Allogeneic Hematopoietic Cell Transplantation Complications (PHOEBUS Trial)

NCT05762211Transplant Complication

DrugPooled allogeneic fecal microbiotherapy

MaaT Pharma

Phase 2

387

Angers, Besançon, Caen, La Tronche, Lille, Limoges, Marseille, Montpellier

2023-10-31

By invitation

Long-Term Safety and Efficacy of Tegoprubart in Kidney Transplant Recipients

NCT06126380Kidney Transplant Rejection

DrugsTegoprubart·Tacrolimus

Eledon Pharmaceuticals

Phase 2

132

Bordeaux, Grenoble, Limoges, Toulouse

2023-10-25

Active, closed

A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.

NCT05984277Metastatic Non-small Cell Lung Cancer

DrugsVolrustomig·Pemetrexed·Paclitaxel·Carboplatin

AstraZeneca

Phase 3

895

Angers, Avignon, Bayonne, Bordeaux, Caen, Lille, Limoges, Marseille

2023-10-24

Recruiting

Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy

NCT05840562Chemotherapy-induced Peripheral Neuropathy

DrugsCapsaicin·Duloxetine

Institut Cancerologie de l'Ouest

Phase 3

274

Angers, Bordeaux, Caen, Grenoble, Limoges, Lyon, Nantes, Nice

2023-10-20

Recruiting

Thromboprophylaxis in Good and Intermediate Prognosis Advanced Germ Cell Tumors

NCT05874063Germ Cell Tumor

Gustave Roussy, Cancer Campus, Grand Paris

Phase 3

387

Angers, Bayonne, Bordeaux, Brest, Clermont-Ferrand, Grenoble, Lille, Limoges

2023-10-17

Active, closed

Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

NCT06008756Arteriosclerosis, Hypercholesterolaemia

DrugsEnlicitide Decanoate·Enlicitide

Merck Sharp & Dohme LLC

Phase 3

14,550

Grenoble, Chambray-lès-Tours, Orléans, Dijon, Le Coudray, Nîmes, Limoges, Rennes

2023-10-09

Active, closed

Azacitidine Combined With Venetoclax in Patients With Higher-risk Chronic Myelomonocytic Leukemia (AVENHIR)

NCT05768711Chronic Myeloid Leukemia

DrugVenetoclax

Groupe Francophone des Myelodysplasies

Phase 2

Amiens, Angers, Bobigny, Cesson-Sévigné, Grenoble, Lille, Limoges, Mont-de-Marsan

2023-10-04

Recruiting

TRansmural hEaliNg Definition in CroHn's Disease (TRENCH 1)

NCT05903066Crohn Disease

Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives

Observational

210

Amiens, Bordeaux, Boulogne-Billancourt, Clermont-Ferrand, Colombes, Lille, Limoges, Marseille

2023-09-28

Active, closed

Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)

NCT06088290Leiomyosarcoma

DrugsLurbinectedin·Doxorubicin

PharmaMar

Phase 3

469

Lyon, Besançon, Angers, Nice, Bordeaux, Lille, Limoges, Marseille

2023-09-21

Active, closed

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

NCT05904886Hepatocellular Carcinoma

DrugsTiragolumab·Tecentriq·Avastin·Atezolizumab

Hoffmann-La Roche

Phase 3

687

Caen, Lille, Limoges, Marseille, Nantes, Paris, Reims, Valence

2023-09-14

Recruiting

Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)

NCT05722938Community-acquired Pneumonia

Biotest

Phase 3

590

Nice, Reims, Strasbourg, Colombes, Limoges, Rennes, Tours, Grenoble

2023-09-09

Recruiting

Prospective Imaging Assessment of Perineo-pelvic Static's Evolution After Sexual Reassignment Surgery in MtF Transgender Patient, by Peno-scrotal Inversion Vaginoplasty Technique (TRANSPELV)

NCT06093724Transgenderism

University Hospital, Limoges

Not applicable

Limoges

2023-09-08

Active, closed

Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis

NCT05727371Knee Osteoarthritis

RegenLab France SAS

Not applicable

280

Dijon, Corbeil-Essonnes, Créteil, La Roche-sur-Yon, Limoges, Lyon, Montpellier, Nantes

2023-08-21

Recruiting

A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.

NCT05967689Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations

DrugZipalertinib

Taiho Oncology, Inc.

Phase 2

220

Strasbourg, Lyon, Caen, Limoges, Pessac, Marseille, Saint-Herblain, Boulogne-Billancourt

2023-07-31

Recruiting

Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients

NCT05843786Pneumonia, Ventilator-Associated

Hospices Civils de Lyon

Phase 3

132

Limoges, Lyon, Nancy, Paris, Pierre-Bénite, Saint-Etienne

2023-06-30

Recruiting

Rituximab Therapy in Anti-Myelin Associated Glycoprotein Patients With Characteristics of Good Responders

NCT05136976Anti-MAG Neuropathy

DrugRituximab

Centre Hospitalier Universitaire de Saint Etienne

Phase 3

Brest, Grenoble, Lille, Limoges, Lyon, Marseille, Nancy, Nantes

2023-06-29

Recruiting

IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

NCT05742607Non Small Cell Lung Cancer

DrugDurvalumab

Innate Pharma

Phase 2

Angers, Caen, Lille, Limoges, Lyon, Marseille, Rennes, Rouen

2023-06-23

Active, closed

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

NCT05827016Multiple Myeloma

DrugsIberdomide·Lenalidomide

Bristol-Myers Squibb

Phase 3

1,230

Amiens, Caen, Créteil, La Roche-sur-Yon, Lille, Limoges, Nantes, Paris

2023-06-22

Recruiting

Ganciclovir Resistant/Refractory Cytomegalovirus Infection in SOT Recipients and HSCT Patients

NCT05234723Cytomegalovirus Infections

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Limoges

2023-06-19

Active, closed

A Phase 2 Study of Gemtuzumab Ozogamicin (GO)-Gilteritinib Combination in Adults With FLT3-ITD and/or FLT3-TKD Relapse/Refractory (R/R) AML

NCT05199051AML, Leukaemia (Acute Myeloid)

Centre Antoine Lacassagne

Phase 2

Amiens, Angers, Bordeaux, Caen, Chambéry, Clamart, Limoges, Nancy

2023-06-03

Recruiting

RItuximab Versus Ocrelizumab in Relapsing-remitting Multiple Sclerosis.

NCT05758831Multiple Sclerosis, Relapsing-remitting Multiple Sclerosis

Rennes University Hospital

Phase 3

386

Lyon, Brest, Caen, Cergy-Pontoise, Clermont-Ferrand, Gonesse, Lille, Limoges

2023-06-01

Active, closed

Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer

NCT05740566Small Cell Lung Cancer (SCLC)

DrugsAmrubicin·Lurbinectedin·Tarlatamab·Topotecan

Amgen

Phase 3

509

Grenoble, Lille, Limoges, Lyon, Marseille, Paris, Pierre-Bénite, Rennes

2023-05-31

Active, closed

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

NCT05840211Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast Cancer

DrugsAbraxane·Xeloda·Sacituzumab Govitecan·Taxol

Gilead Sciences

Phase 3

654

Besançon, Bordeaux, Dijon, Lille, Limoges, Loire Atlantique, Lyon, Marseille

2023-05-08

Active, closed

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

NCT05714202Bladder Cancer

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 3

1,135

Bordeaux, Clermont-Ferrand, Grenoble, Limoges, Lyon, Nantes, Nîmes, Orléans

2023-03-23

Active, closed

COMPArative Study of the Consequence on innaTe Immune Response du to Bacterial or Viral Infection in Patients Admitted to Intensive Care Unit

NCT05671159Viral Infection, Sepsis

University Hospital, Limoges

Not applicable

Limoges

2023-02-19

Active, closed

A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

NCT05578976Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone

Genmab

Phase 3

900

Nice, Clermont, Marseille, Rennes, Dijon, Limoges, Montpellier, La Tronche

2023-02-08

Active, closed

Treatment Pause Versus Treatment Continuation in IMDC Good or Intermediate Risk With Only One Adverse Prognostic Factor in mRCC Patients With an Objective Response at 12 Months of Treatment With PD1/ PDL1 ICIs + VEGFR-Tyrosine Kinase Inhibitors

NCT05219318Metastatic Renal Cell Carcinoma, Good or Only One Adverse Prognostic Factor Intermediate Risk Per IMDC Score

DrugVegfr-Tki

University Hospital, Bordeaux

Phase 3

Bayonne, Bordeaux, Caen, Clermont-Ferrand, Créteil, Dijon, Grenoble, Limoges

2023-01-23

Active, closed

Phase 2b Study of GSK4532990 in Adults With NASH

NCT05583344Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease

DrugGSK4532990

GlaxoSmithKline

Phase 2

284

Angers, Limoges, Paris, Pierre-Bénite, Strasbourg

2023-01-02

Recruiting

Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantation

NCT04935684Acute Leukemia in Remission, Myelodysplastic Syndromes, Myeloproliferative Syndrome, Hodgkin Lymphoma

DrugFecal Microbiota Transplantation

University Hospital, Clermont-Ferrand

Phase 2

150

Amiens, Angers, Besançon, Clermont-Ferrand, Grenoble, Lille, Limoges, Lyon

2022-12-20

Recruiting

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

NCT05633654Triple Negative Breast Cancer

DrugsXeloda·Sacituzumab Govitecan·Keytruda·Capecitabine

Gilead Sciences

Phase 3

1,514

Amiens, Chambray-lès-Tours, Dijon, Le Mans, Limoges, Loire Atlantique, Lyon, Nancy

2022-12-12

Recruiting

Evaluation of the Effectiveness of the Parkinson Specialized Teams Intervention

NCT05433441Parkinson Disease

University Hospital, Bordeaux

Not applicable

250

Bordeaux, Lille, Limoges, Poitiers

2022-12-06

Active, closed

Staging System in Amyotrophic Lateral Sclerosis

NCT04858555Amyotrophic Lateral Sclerosis

University Hospital, Limoges

Observational

Limoges, Tours

2022-12-02

Active, closed

Venetoclax in Patients With MDS or AML in Relapse After AHSCT

NCT05226455MDS, AML

DrugsDonor lymphocyte·Azacitidine·Venetoclax

Groupe Francophone des Myelodysplasies

Phase 1/2

Angers, Grenoble, Limoges, Montpellier, Nantes, Nice, Paris, Pessac

2022-11-23

Recruiting

Contact Aspiration Versus Stent Retriever for Recanalisation of Acute Stroke Patients With Basilar Artery Occlusion: The Posterior Circulation ASTER Randomized Trial Protocol

NCT05320263Basilar Artery Occlusion

Hopital Foch

Not applicable

480

Bordeaux, Caen, Limoges, Montpellier, Nancy, Nantes, Paris, Reims

2022-11-19

Active, closed

Dazucorilant in Patients With Amyotrophic Lateral Sclerosis

NCT05407324Amyotrophic Lateral Sclerosis

Corcept Therapeutics

Phase 2

279

Bron, Lille, Limoges, Marseille, Montpellier, Nice, Paris, Tours

2022-11-15

Recruiting

Deescalation of Endocrine Therapy Duration in Women With HR+ HER2- Breast Cancer at Very Low Risk

NCT05297617Breast Cancer

UNICANCER

Phase 2

696

Limoges, Villejuif

2022-10-12

Active, closed

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

NCT05556512Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

15,374

Corbeil-Essonnes, La Tronche, Le Coudray, Le Creusot, Limoges, Nice, Paris, Pierre-Bénite

2022-10-11

Recruiting

Comparison of Functional Outcomes of Ejaculation-preserving Partial Trans Urethral Resection of the Prostate With Complete Trans Urethral Resection of the Prostate for Benign Prostatic Obstruction

NCT05574244Benign Prostatic Hyperplasia

University Hospital, Bordeaux

Not applicable

336

Aix-en-Provence, Angers, Bordeaux, Créteil, Lille, Limoges, Marseille, Nice

2022-09-29

Recruiting

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT05519085Relapsed or Refractory Multiple Myeloma

DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib

Celgene

Phase 3

810

Pessac, Lyon Cedex08, Lille, Clermont-Ferrand, Limoges, Nantes, Nîmes, Strasbourg

2022-09-20

Active, closed

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma

NCT05409066Follicular Lymphoma (FL)

DrugsEpcoritamab·Lenalidomide·Rituximab

Genmab

Phase 3

549

Clermont, Rennes, Caen, Dijon, Limoges, Nîmes, Reims, Vandœuvre-lès-Nancy

2022-09-20

Active, closed

Determinants of Daily Physical Activity Level in Patients With Cystic Fibrosis - Pilot Study Protocol

NCT05206097Cystic Fibrosis

University Hospital, Limoges

Not applicable

Bordeaux, Limoges, Toulouse

2022-09-19

Recruiting

De-escalation Study for Stage IIa/IIb < 3 cm Seminoma

NCT05529251Seminoma, Stage II

DrugCarboplatin AUC7

Centre Leon Berard

Phase 2

Besançon, Bordeaux, Caen, Clermont-Ferrand, Lille, Limoges, Lyon, Marseille

2022-09-06

Active, closed

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

NCT05388669Advanced or Metastatic Non-small Cell Lung Cancer

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 3

418

La Tronche, Lille, Limoges, Marseille

2022-08-05

Recruiting

Perpetual Observational Study - Ventilator Associated Pneumonia

NCT05719259Ventilator Associated Pneumonia

European Clinical Research Alliance for Infectious Diseases (ECRAID)

Observational

20,000

Chalon-sur-Saône, Dijon, Le Mans, Lille, Limoges, Tours

2022-08-03

Recruiting

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma

DrugsPirtobrutinib·Ibrutinib

Loxo Oncology, Inc.

Phase 3

737

La Roche-sur-Yon, Le Mans, Limoges, Nantes, Nice, Paris, Pierre-Bénite, Rennes

2022-07-22

Recruiting

Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation in BRCA 1/2 and HER2-negative, Metastatic or Locally Advanced Breast Cancer.

NCT05378204Breast Cancer

Institut Claudius Regaud

Not applicable

120

Bordeaux, Caen, Clermont-Ferrand, Dijon, La Roche-sur-Yon, Lille, Limoges, Lyon

2022-06-23

Recruiting

A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia

NCT05304377Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Cml

DrugELVN-001

Enliven Therapeutics

Phase 1

250

Amiens, Bordeaux, Lille, Limoges, Lyon, Pierre-Bénite

2022-05-22

Active, closed

A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)

NCT05374512Breast Cancer

DrugsEribulin·Dato-DXd·Nab-paclitaxel·Capecitabine

AstraZeneca

Phase 3

644

Bordeaux, Dijon, Limoges, Lyon, Marseille, Montpellier, Paris, Rouen

2022-05-16

Active, closed

Observational Study of the Use of 8% Capsaicin Patch in Children 0 to 18 Years Old

NCT05299294Neuropathic Pain, Chronic Pain

University Hospital, Brest

Observational

160

Angers, Bordeaux, Bourg-en-Bresse, Brest, Caen, Lille, Limoges, Marseille

2022-05-12

Recruiting

Nivolumab and Ipilimumab in Anti-PD1-Resistant dMMR/MSI mCRC

NCT05310643Metastatic Colorectal Cancer

DrugsYervoy·Ipilimumab·Opdivo·Nivolumab

GERCOR - Multidisciplinary Oncology Cooperative Group

Phase 2

Besançon, Bordeaux, Lille, Limoges, Lyon, Montpellier, Nice, Paris

2022-05-05

Recruiting

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

NCT05061550Non-small Cell Lung Cancer

DrugsAZD0171·Pemetrexed/Cisplatin·Pemetrexed/Carboplatin·Monalizumab

AstraZeneca

Phase 2

630

Avignon, Bobigny, Bordeaux, Limoges, Rennes, Rouen, Suresnes, Toulon

2022-04-14

Recruiting

Childhood Traumas in Obese Women: Association With Deregulation of the Glucocorticoid Axis and Inflammatory State.

NCT05237440Obesity

University Hospital, Limoges

Not applicable

102

Limoges

2022-04-13

Recruiting

Comparison of Two sTRAtegies For the Non-Invasive Diagnosis of advanCed Liver Fibrosis in NAFLD

NCT04681573NAFLD

University Hospital, Angers

Not applicable

1,045

Angers, Besançon, Bobigny, Dijon, La Roche-sur-Yon, La Tronche, Lille, Limoges

2022-04-07

By invitation

Trial of Sibeprenlimab in the Treatment of Immunoglobulin A Nephropathy (IgAN)

NCT05248659Immunoglobulin A Nephropathy

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 2/3

600

Grenoble, Nîmes, Nantes, Limoges, Sr Priest En Jarez

2022-04-05

Active, closed

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

NCT05312879Proteinuric Kidney Disease

Vertex Pharmaceuticals Incorporated

Phase 2/3

522

Créteil, Grenoble, Le Kremlin-Bicêtre, Limoges, Marseille, Paris, Pointe à Pitre, Saint-Ouen

2022-03-30

Recruiting

A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus

NCT04867590Barrett Esophagus, Dysplasia

University Hospital, Angers

Not applicable

140

Besançon, Brest, Chambray-lès-Tours, Dijon, Lille, Limoges, Lyon, Montpellier

2022-03-25

Active, closed

Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)

NCT05224141Small Cell Lung Carcinoma

DrugsPembrolizumab/Vibostolimab·Platinol·Tecentriq·Paraplatin

Merck Sharp & Dohme LLC

Phase 3

460

Marseille, Toulouse, Limoges

2022-03-24

Active, closed

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

NCT05250973Amyloidosis

DrugsBortezomib·Daratumumab·Dexamethasone·Cyclophosphamide

Janssen Research & Development, LLC

Phase 2

151

Limoges, Pierre-Bénite, Poitiers, Toulouse

2022-03-01

Recruiting

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

NCT04988555Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute, Multiple Myeloma, Myelodysplastic Syndromes

DrugsAzoles·Gilteritinib·Azacitidine·Venetoclax

Sumitomo Pharma America, Inc.

Phase 1/2

606

Angers, Bobigny, Le Mans, Lille, Limoges, Lyon, Marseille, Nantes

2022-02-28

Active, closed

Impact of 18F-FES PET on the Therapeutic Treatment of Patients With Metastatic Breast Cancer

NCT05486182Metastatic Breast Cancer

GE Healthcare

Phase 4

153

Dijon, La Tronche, Limoges, Lyon, Montpellier, Neuilly-sur-Seine, Nice, Paris

2022-02-08

Recruiting

Better Understand Motor Deficits Associated With Autism Spectrum Disorders: Development of an Assessment Protocol

NCT05236803Autism Spectrum Disorder

Centre Hospitalier Charles Perrens, Bordeaux

Not applicable

110

Bordeaux, La Rochelle, Limoges, Poitiers

2022-02-07

Active, closed

Pulmonary Function in Patients Recovering From COVID19 Infection : a Pilot Study

NCT05074927COVID-19

University Hospital, Limoges

Not applicable

Limoges

2022-01-31

Active, closed

Study of Drug Acceptance and Its Persistence Over Time in Patients Receiving a Haematopoietic Stem Cell Allograft

NCT05164835Allograft

University Hospital, Limoges

Not applicable

Limoges

2022-01-26

Active, closed

LVIS™ Evo™ and HydroCoil® Embolic System for Intracranial Aneurysm Treatment

NCT04999423Intracranial Aneurysm

Microvention-Terumo, Inc.

Observational

206

Brest, Limoges, Lyon, Marseille, Paris, Rouen

2022-01-14

Recruiting

Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)

NCT05009927Metastatic Gastrointestinal Stromal Tumor (GIST), C-KIT Mutation, Advanced Gastrointestinal Stromal Tumor (GIST)

DrugsGlivec·Imatinib

Centre Leon Berard

Phase 2

Besançon, Bordeaux, Limoges, Lyon, Marseille, Paris, Reims, Rennes

2022-01-03

Active, closed

Study of Tafasitamab and Lenalinomide Associated to Rituximab in Frontline Diffuse Large B-Cell Lymphoma Patients of 80 y/o or Older

NCT04974216DLBCL

DrugsTafasitamab·Lenalidomide·Rituximab

The Lymphoma Academic Research Organisation

Phase 2

Avignon, Bayonne, Besançon, Bordeaux, Corbeil-Essonnes, La Roche-sur-Yon, Lille, Limoges

2021-12-20

Active, closed

Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).

NCT05116189Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

DrugsZirabev·Taxotere·Avastin·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

643

Brest, Caen, Limoges, Saint-Cloud, Rennes, Montpellier, Nantes

2021-12-13

Active, closed

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)

NCT05156281Relapsing Multiple Sclerosis

DrugsTeriflunomide·Remibrutinib

Novartis Pharmaceuticals

Phase 3

1,007

Limoges, Toulon, Caen, Clermont-Ferrand, Dijon, Gonesse, Grenoble, Lille

2021-12-13

Recruiting

Adult Tic Disorders Registry

NCT05090943Tic Disorders

Assistance Publique - Hôpitaux de Paris

Observational

450

Clermont-Ferrand, Limoges, Marseille, Paris, Poitiers, Saint-Herblain, Strasbourg

2021-12-01

Recruiting

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis

Blueprint Medicines Corporation

Phase 2/3

534

Amiens, Caen, Grenoble, Limoges, Nantes, Paris, Poitiers, Toulouse

2021-11-30

Active, closed

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

NCT05030428Atherosclerotic Cardiovascular Disease

DrugInclisiran sodium

Novartis Pharmaceuticals

Phase 3

17,004

Limoges, Amiens, Béziers, Brest, Chambray-lès-Tours, Cholet, Clermont-Ferrand, Corbeil-Essonnes

2021-11-23

Active, closed

Onco-haematology Vigilance Card

NCT04931329Medical Oncology, Hematology, Molecular Targeted Therapies

University Hospital, Limoges

Observational

100

Limoges

2021-11-08

Active, closed

A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05083169Multiple Myeloma

DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab

Janssen Research & Development, LLC

Phase 3

587

Créteil, Lille, Limoges, Lyon, Nantes, Poitiers, Strasbourg, Toulouse

2021-10-14

Recruiting

A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments

NCT05020236Multiple Myeloma

DrugsDarzalex·Elranatamab·Pomalidomide·Daratumumab

Pfizer

Phase 3

893

Limoges, Lille, Nantes, Paris, Pierre-Bénite, Poitiers, Toulouse

2021-10-04

Recruiting

Intestine-lung Axis of Cystic Fibrosis Patients Treated With the Combination Elexacaftor/Tezacaftor/Ivacaftor

NCT05937815Cystic Fibrosis

University Hospital, Bordeaux

Not applicable

253

Bordeaux, Grenoble, Lille, Limoges, Lyon, Marseille, Montpellier, Nancy

2021-09-13

Active, closed

Safety, Tolerability, Pharmacokinetics and Efficacy Study of Radotinib in Parkinson's Disease

NCT04691661Parkinson Disease

DrugRadotinib HCl

Il-Yang Pharm. Co., Ltd.

Phase 2

Lille, Limoges, Lyon, Nantes, Paris, Poitiers, Rouen

2021-09-09

Recruiting

Clinical Trial Assessing the Immunogenicity of an Anti-pneumococcal Vaccination Strategy (PCV13+PPV23 Versus PREVENAR20) in Adult Patients Treated for a Lymphoma

NCT04460235Vaccine, Streptococcus Pneumoniae, Lymphoma, Non-Hodgkin

Poitiers University Hospital

Phase 4

160

Angers, Bordeaux, Limoges, Nantes, Périgueux, Poitiers, Tours

2021-09-07

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)

NCT04961996Early Breast Cancer

DrugGiredestrant

Hoffmann-La Roche

Phase 3

4,170

Caen, Limoges, Montpellier, Argenteuil, Brest, Grenoble, La Roche-sur-Yon, Le Mans

2021-08-27

Recruiting

Addition of Pembrolizumab to the Standard of Care Chemotherapy in Patient With SCCOHT

NCT04602377Small Cell Ovarian Carcinoma

DrugsKeytruda·Pembrolizumab

ARCAGY/ GINECO GROUP

Phase 2

Angers, Besançon, Bordeaux, Dijon, Lille, Limoges, Lyon, Montpellier

2021-08-04

Active, closed

Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis

NCT04779593Haemochromatosis

DrugBioBank

Rennes University Hospital

Not applicable

239

Bobigny, Limoges, Lorient, Mulhouse, Orléans, Paris, Rennes, Saint-Brieuc

2021-07-02

Active, closed

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

NCT04964934ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Anastrozole·Ribociclib·Abemaciclib

AstraZeneca

Phase 3

315

Avignon, Brest, Clermont-Ferrand, Dijon, Limoges, Lorient, Lyon, Marseille

2021-06-30

Recruiting

Study of Repetitive Behaviors in Alzheimer's Disease

NCT07732842Alzheimer Disease, Anterograde Amnesia, Anosognosia

Centre Hospitalier Esquirol

Observational

103

Limoges

2021-06-24

Recruiting

Patritumab Deruxtecan (U3-1402) in Unresectable Locally Advanced or Metastatic Breast Cancer

NCT04965766Metastatic Breast Cancer, Advanced Breast Cancer

DrugPatritumab deruxtecan

Gustave Roussy, Cancer Campus, Grand Paris

Phase 2

139

Dijon, Limoges, Lyon, Marseille, Montpellier, Nice, Paris, Saint-Herblain

2021-05-11

Active, closed

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Ribociclib·Abemaciclib·Palbociclib

AstraZeneca

Phase 3

893

Bobigny, Limoges, Lyon, Plérin, Rouen, Saint-Herblain, Villejuif

2021-05-10

Active, closed

A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease

NCT04777331Parkinsons Disease

DrugPrasinezumab

Hoffmann-La Roche

Phase 2

586

Bordeaux, Bron, Clermont-Ferrand, Créteil, Grenoble, Limoges, Marseille, Montpellier

2021-05-05

Recruiting

Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group

NCT03967834Soft Tissue Sarcoma, Clear Cell Sarcoma, Epithelioid Sarcoma, Perivascular Epithelioid Cell Neoplasms

Institut Claudius Regaud

Not applicable

400

Besançon, Bordeaux, Clermont-Ferrand, Dijon, Lille, Limoges, Lyon, Marseille

2021-04-26

Active, closed

Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)

NCT04700124Bladder Cancer

DrugsEnfortumab Vedotin·Platinol·Keytruda·Gemcitabine

Merck Sharp & Dohme LLC

Phase 3

808

Marseille, Besançon, Brest, Toulouse, Limoges, La Tronche, Orléans, Lille

2021-04-21

Active, closed

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

NCT04736706Carcinoma, Renal Cell

DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda

Merck Sharp & Dohme LLC

Phase 3

1,688

Marseille, Besançon, Toulouse, Limoges, Beuvry, Angers, Pierre-Bénite, Paris

2021-04-14

Recruiting

Creation of a Register of Patients With Neonatal-onset Epileptic Encephalopathy

NCT04802135Epileptic Encephalopathy

Assistance Publique Hopitaux De Marseille

Observational

200

Angers, Bordeaux, Brest, Lille, Limoges, Lyon, Marseille, Montpellier

2021-03-06

Active, closed

A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

NCT04586231Carcinoma, Renal Cell

DrugsBelzutifan·Cabozantinib·Lenvatinib

Merck Sharp & Dohme LLC

Phase 3

747

Reims, Nice, Strasbourg, Bordeaux, Toulouse, Limoges, Saint-Herblain, Angers

2021-02-25

Recruiting

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

NCT03127267Amyotrophic Lateral Sclerosis

DrugsMasitinib·Riluzole

AB Science

Phase 3

495

Angers, Bordeaux, Bron, Clermont-Ferrand, Lille, Limoges, Marseille, Montpellier

2021-02-02

Active, closed

A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)

NCT04628494Diffuse Large B-cell Lymphoma

DrugEpcoritamab

Genmab

Phase 3

483

Amiens, Bayonne, Brest, Caen, La Rochelle, Limoges, Lyon, Marseille

2021-01-13

Recruiting

Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management

NCT03997253Organ Transplantation

University Hospital, Limoges

Not applicable

430

Limoges, Poitiers, Rennes, Tours

2020-12-21

Active, closed

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

NCT04640623Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 2

220

Bordeaux, Grenoble, Hyères, Limoges, Lyon, Marseille, Montpellier, Nîmes

2020-12-18

Active, closed

A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

NCT04658862Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab·Gemcitabine·Cisplatin

Janssen Research & Development, LLC

Phase 3

518

Bordeaux, Brest, Caen, Chambray-lès-Tours, Hyères, Lille, Limoges, Lyon

2020-12-07

Recruiting

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer

DrugsAdagrasib·Pembrolizumab

Mirati Therapeutics Inc.

Phase 2/3

626

Angers, Boulogne-Billancourt, Brest, Caen, Créteil, La Tronche, Limoges, Lorient

2020-12-02

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)

NCT04512235AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

281

Caen, Créteil, Dijon, Lille, Limoges, Marseille, Paris, Pessac

2020-11-03

Recruiting

Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue Sarcoma

NCT04307277Soft Tissue Sarcoma

Institut Claudius Regaud

Phase 3

600

Besançon, Caen, Clermont-Ferrand, Dijon, Limoges, Lyon, Marseille, Montpellier

2020-10-09

Recruiting

Bougie Sleeve Trial

NCT02937649Morbid Obesity

Assistance Publique - Hôpitaux de Paris

Not applicable

1,658

Boulogne-Billancourt, Caen, Clamart, Créteil, La Tronche, Limoges, Longjumeau, Paris

2020-10-08

Active, closed

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04487080Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Osimertinib

Janssen Research & Development, LLC

Phase 3

1,074

Bordeaux, Bron, La Tronche, Lille, Limoges, Marseille, Paris, Pessac

2020-09-30

Active, closed

A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP, an Autoimmune Disorder That Affects the Peripheral Nerves)

NCT04280718Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

DrugEfgartigimod PH20

argenx

Phase 2

229

Angers, Bordeaux, Clermont-Ferrand, Le Kremlin-Bicêtre, Limoges, Nantes, Nice, Paris

2020-09-18

Active, closed

Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism

NCT04304651Embolism and Thrombosis

University Hospital, Brest

Not applicable

1,276

Morlaix, Agen, Angers, Brest, Clermont-Ferrand, Dijon, Limoges, Paris

2020-09-08

Recruiting

Chemotherapy For Metastatic Grade 3 Poorly Differentiated NEuroendocrine Carcinoma Of GastroEnteroPancreatic And Unknown Primary

NCT04325425Neuroendocrine Carcinoma

DrugsFOLFOXIRI Protocol·Cisplatin·Carboplatin

Centre Hospitalier Universitaire Dijon

Phase 2

218

Caen, Dijon, Limoges, St-Malo, Troyes

2020-09-01

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)

NCT04504825AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

125

Caen, Créteil, Limoges, Marseille, Paris, Pessac, Pierre-Bénite, Poitiers

2020-08-25

Recruiting

Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients

NCT04028401Cutibacterium Acnes Infection

Nantes University Hospital

Phase 3

110

Angers, Brest, Limoges, Nantes, Rennes, Tours

2020-06-19

Active, closed

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma

DrugTazemetostat

Epizyme, Inc.

Phase 3

599

Pessac, Brest, Bordeaux, Mulhouse, Rouen, Limoges, La Tronche, Nantes

2020-06-11

Recruiting

International CIPN Assessment and Validation Study

NCT04633655Chemotherapy-induced Peripheral Neuropathy, Quality of Life

University of Milano Bicocca

Observational

1,000

Clamart, Limoges

2020-06-08

Recruiting

Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study

NCT03582800Systemic Sclerosis, Dermatomyositis, iPPSD2

University Hospital, Limoges

Phase 2

Bordeaux, Bron, Le Kremlin-Bicêtre, Limoges, Paris, Rennes, Rouen, Toulouse

2020-01-06

Recruiting

French Colorectal ESD Cohort in Experts Centers

NCT04592003Cancer Colorectal, Polyps Colorectal, Endoscopic Submucosal Resection

University Hospital, Limoges

Observational

1,200

Amiens, Angers, Besançon, Bordeaux, Brest, Dijon, Limoges, Lyon

2020-01-01

Active, closed

A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer

NCT04165317Non-muscle Invasive Bladder Cancer

DrugsSasanlimab·Bacillus Calmette-Guerin

Pfizer

Phase 3

1,068

Antony, Bayonne, Bordeaux, Brest, Limoges, Nancy, Paris, Strasbourg

2019-12-30

Active, closed

Safety and Efficacy of Silk Vista and Silk Vista Baby Flow Diverter for Intracranial Aneurysm Treatment

NCT04034810Intracranial Aneurysm, Flow Diverter

Balt Extrusion

Observational

234

Bordeaux, Brest, Bron, Caen, Clermont-Ferrand, Grenoble, Le Kremlin-Bicêtre, Limoges

2019-11-04

Recruiting

Sport Surgery Products Outcomes - A Post-market Follow-up

NCT06532929Sport Surgery

Teknimed

Observational

390

Aubenas, Guilherand-Granges, Brive-la-Gaillarde, Bergerac, Toulouse, Limoges, Boujan-sur-Libron, Lunel

2019-11-01

Active, closed

Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation

NCT07030413Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy

Poitiers University Hospital

Observational

2,000

Bordeaux, Limoges, Poitiers

2019-11-01

Active, closed

Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)

NCT04075981Cardiac Surgery

DrugsXeomin·Botulinum toxin type A

Assistance Publique - Hôpitaux de Paris

Phase 3

220

Issy-les-Moulineaux, Le Plessis-Robinson, Limoges, Marseille, Neuilly-sur-Seine, Paris

2019-09-30

Recruiting

Vaginal Native Tissues Repair for Pelvic Organ Prolapse

NCT03875989Prolapse, Vaginal

University Hospital, Limoges

Not applicable

214

Bordeaux, Brive-la-Gaillarde, Clermont-Ferrand, Guéret, Limoges, Saint-Etienne, Toulouse, Tulle

2019-09-27

Active, closed

Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast Cancer

NCT03820830Breast Cancer Recurrent

DrugPalbociclib

ETOP IBCSG Partners Foundation

Phase 3

405

Avignon, Bordeaux, Caen, Cholet, Dijon, Limoges, Lorient, Lyon

2019-08-27

Recruiting

Unruptured Cerebral Aneurysm: Prediction of Evolution

NCT04578808Unruptured Intracranial Aneurysm

Nantes University Hospital

Observational

1,000

Marseille, Brest, Bordeaux, Toulouse, Limoges, Rennes, Tours, Nantes

2019-08-19

Active, closed

A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)

NCT04008030Metastatic Colorectal Cancer

DrugsFluorouracil·Leucovorin·Ipilimumab·Irinotecan

Bristol-Myers Squibb

Phase 3

839

Limoges, Lille, Bayonne, Besançon, Lyon, Marseille, Montpellier, Nantes

2019-08-05

Active, closed

Adjuvant Palbociclib in Elderly Patients With Breast Cancer

NCT03609047Breast Cancer Stage II, Breast Cancer Stage III

DrugsDoxorubicin/cyclophosphamide·Palbociclib·Paclitaxel

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

366

Bordeaux, Brou, Caen, Clermont-Ferrand, La Roche-sur-Yon, Lille, Limoges, Lyon

2019-06-14

Active, closed

IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome

NCT03503409Myelodysplastic Syndromes, Acute Myeloid Leukemia

DrugIvosidenib

Groupe Francophone des Myelodysplasies

Phase 2

Angers, Bayonne, Belfort, Caen, Grenoble, Le Mans, Limoges, Lyon

2019-05-14

Active, closed

A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis

NCT03900429NASH - Nonalcoholic Steatohepatitis

DrugResmetirom

Madrigal Pharmaceuticals, Inc.

Phase 3

1,759

Strasbourg, Lyon, Clermont-Ferrand, Rennes, Besançon, Lille, Montpellier, Limoges

2019-03-28

Active, closed

Treatment Intensification With Temozolomide in Adults With a Glioblastoma

NCT03663725Glioblastoma

DrugStupp protocol

Centre Oscar Lambret

Phase 3

486

Amiens, Caen, Clermont-Ferrand, Colmar, Dijon, Grenoble, Limoges, Lyon

2019-03-13

Recruiting

Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas

NCT03805022Non-metastatic Soft-tissue Sarcoma, Resectable

DrugsDacarbazine·Ifosfamide·Doxorubicin

Institut Bergonié

Phase 3

351

Bordeaux, Dijon, Limoges, Lyon, Marseille, Montpellier, Saint-Herblain, Strasbourg

2019-02-14

Recruiting

Evaluation of Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic Low Grade Endometrial Stromal Sarcoma (LGESS)

NCT03624244Low Grade Endometrial Stromal Sarcoma

DrugsExemestane·Anastrozole·Letrozole

Centre Leon Berard

Phase 2

Besançon, Bordeaux, Caen, Clermont-Ferrand, Lille, Limoges, Lyon, Marseille

2019-01-23

Active, closed

Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

NCT03737643Advanced Ovarian Cancer

DrugsOlaparib·Durvalumab·Paclitaxel·Bevacizumab

AstraZeneca

Phase 3

1,407

Besançon, Bordeaux, Limoges, Lyon, Marseille, Nantes, Paris, Saint-Herblain

2019-01-04

Active, closed

A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve

NCT03682536Myelodysplastic Syndromes

DrugsEpoetin Alfa·Luspatercept

Celgene

Phase 3

363

Angers, Bayonne, Caen, La Tronche, Le Mans, Lille, Limoges, Nantes

2019-01-02

Recruiting

Dat'Aids Prevention

NCT03795376HIV Prevention

DatAids

Observational

6,500

Belfort, Besançon, Brest, Clermont-Ferrand, La Roche-sur-Yon, Le Kremlin-Bicêtre, Limoges, Lyon

2019-01-01

Active, closed

NK Cell Deregulation in HBV Patients

NCT03761875Hepatitis B Virus

University Hospital, Limoges

Not applicable

Limoges

2018-12-11

Active, closed

A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer

NCT03701334Early Breast Cancer

DrugRibociclib

Novartis Pharmaceuticals

Phase 3

5,101

Nice, Dijon, Limoges, Saint-Cloud, Rennes, Grenoble, Lyon, Amiens

2018-12-07

Active, closed

Shared Medical Decision Making in the Prophylactic Treatment of Bipolar Disorder

NCT03245593Bipolar Disorder

Centre Hospitalier Universitaire de Nīmes

Not applicable

300

Béziers, Bordeaux, Bron, Clermont-Ferrand, Créteil, Grenoble, Limoges, Marseille

2018-04-24

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

NCT03425643Non-small Cell Lung Cancer

DrugsPlatinol·Pemetrexed·Keytruda·Gemcitabine

Merck Sharp & Dohme LLC

Phase 3

797

Suresnes, Pierre-Bénite, Strasbourg, Toulouse, Limoges, Chambéry, Pringy, Rouen

2018-04-24

Active, closed

Adjuvant Radiotherapy in Patients With Pathological High-risk Bladder Cancer (GETUG-AFU 30)

NCT03333356Patients With High-risk MIBC

UNICANCER

Not applicable

Angers, Bordeaux, Caen, Dijon, Grenoble, Lille, Limoges, Lorient

2018-04-19

Active, closed

A Study of Combination Therapy With Venetoclax, Daratumumab and Dexamethasone (With and Without Bortezomib) in Participants With Relapsed or Refractory Multiple Myeloma

NCT03314181Multiple Myeloma

DrugsVenclexta·Bortezomib·Daratumumab·Venetoclax

AbbVie

Phase 2

156

Limoges, Tours, Nantes, Villejuif, Poitiers, Paris

2018-04-02

Recruiting

FARD (RaDiCo Cohort) (RaDiCo-FARD)

NCT05954416Inherited Epidermolysis Bullosa, Ichthyosis, Ectodermal Dysplasia, Incontinentia Pigmenti

Institut National de la Santé Et de la Recherche Médicale, France

Observational

900

Bobigny, Bordeaux, Créteil, Dijon, Limoges, Marseille, Montpellier, Nice

2018-03-07

Recruiting

CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome

NCT02812212Ureteropelvic Junction Obstruction

Centre Hospitalier Universitaire de la Réunion

Not applicable

Bordeaux, Limoges, Nantes, Rennes, Saint-Denis

2017-11-28

Active, closed

A Study Comparing Zanubrutinib With Bendamustine Plus Rituximab in Participants With Previously Untreated CLL or SLL

NCT03336333Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsBendamustine·Venclexta·Zanubrutinib·Venetoclax

BeiGene

Phase 3

590

Argenteuil, Bordeaux, Caen, La Roche-sur-Yon, Le Mans, Limoges, Marseille, Nantes

2017-10-31

Recruiting

Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis

NCT03268668Stroke, Acute, Biological Specimen Banks, Biomarkers, Etiology

Fondation Ophtalmologique Adolphe de Rothschild

Observational

1,200

Bordeaux, Caen, Limoges, Nancy, Nantes, Paris, Rennes, Suresnes

2017-07-13

Recruiting

Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures

NCT05361603Hepatitis C, Transmission, Intravenous Drug Abuser, Addiction, Alcohol, Addiction Opiate

University Hospital, Limoges

Observational

1,500

Limoges

2017-05-24

Active, closed

A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

NCT02972840Lymphoma, Mantle Cell

DrugsAcalabrutinib·Bendamustine·Rituximab

Acerta Pharma BV

Phase 3

635

Argenteuil, Bobigny, Bordeaux, Le Mans, Limoges, Pessac, Périgueux, Rennes

2017-04-05

Recruiting

IDMet (RaDiCo Cohort) (RaDiCo-IDMet)

NCT05945576Silver Russell Syndrome, Beckwith-Wiedemann Syndrome, Transient Neonatal Diabetes Mellitus, Angelman Syndrome

Institut National de la Santé Et de la Recherche Médicale, France

Observational

2,000

Angers, Besançon, Clermont-Ferrand, Le Kremlin-Bicêtre, Lille, Limoges, Lyon, Marseille

2017-03-10

Active, closed

Feasibility of Molecular Biology in Pancreatic Cyst Tumors

NCT03305146Pancreatic Cyst, Pancreas Cyst, Serous Cystadenoma, Mucinous Cystadenoma

Hospital St. Joseph, Marseille, France

Not applicable

Charenton-le-Pont, Limoges, Lyon, Marseille, Nantes, Nice, Paris, Vichy

2017-01

Active, closed

Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation

NCT02871167Breast Cancer

Centre Oscar Lambret

Not applicable

140

Bondy, Bordeaux, Caen, Clamart, Dijon, La Réunion, Lille, Limoges

2016-12

Active, closed

Nationwide Observation Study to Evaluate the Efficacy and Tolerance of the Adjustable Medical Device REMEEX® in the Treatment of Male Stress Urinary Incontinence

NCT03650244Urinary Incontinence,Stress

Centre Hospitalier Universitaire de Nīmes

Observational

100

Besançon, Créteil, Dijon, Limoges, Nancy, Nice, Nîmes, Strasbourg

2016-11-16

Active, closed

Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis

NCT02817958Penile Cancer, Squamous Carcinoma

UNICANCER

Phase 2

Angers, Besançon, Bordeaux, Caen, Clermont-Ferrand, Limoges, Lyon, Marseille

2016-10-17

Active, closed

Study to Evaluate Imetelstat (GRN163L) in Participants With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

NCT02598661Myelodysplastic Syndromes

DrugImetelstat Sodium

Geron Corporation

Phase 2/3

289

Nice, Tours, Limoges, La Tronche, Vandœuvre-lès-Nancy, Le Mans, Poitiers, Angers

2016-01-12

Active, closed

AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.

NCT02511106Stage IB-IIIA Non-small Cell Lung Carcinoma

DrugOsimertinib

AstraZeneca

Phase 3

682

Bron, Lille, Limoges, Lyon, Paris

2015-10-21

Recruiting

Treatment of Brain AVMs (TOBAS) Study

NCT02098252Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation, Arteriovenous Malformations, AVM

Centre hospitalier de l'Université de Montréal (CHUM)

Not applicable

1,000

Brest, Besançon, Bordeaux, Caen, Clermont-Ferrand, Dijon, Le Kremlin-Bicêtre, Limoges

2014-05

Recruiting

Chronic Myeloid Leukemia (CML) Real-Life Database

NCT05963061Chronic Myeloid Leukemia (CML)

University Hospital, Clermont-Ferrand

Observational

3,500

Annecy, Caen, Clermont-Ferrand, Le Puy-en-Velay, Limoges, Marseille, Nancy, Paris

2014-04-16

Active, closed

French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders

NCT01842763Refractory Chronic Headache Disorders

Centre Hospitalier Universitaire de Nice

Observational

246

Colmar, Clermont-Ferrand, Épagny, Grenoble, Lille, Limoges, Lyon, Marseille

2013-03

Active, closed

Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)

NCT01838512Multiple Myeloma

Bristol-Myers Squibb

Observational

2,555

Blois, Chalon-sur-Saône, La Roche-sur-Yon, Limoges, Meaux, Nantes, Rennes

2012-06-13

Active, closed

Long Term Follow up of a Cohort of Children With TCF2 Mutation:Evolution of Endocrine and Renal Function

NCT00760331Hepatocyte Nuclear Factor 1-beta

University Hospital, Limoges

Observational

100

Limoges

2008-06

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a French investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 1 November 2026. https://priyalifescience.com/clinical-trials-france/city/limoges

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in France and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,722 studies in total at the last sync on 29 Oct 2026, 03:20 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 325 of those studies with a site in Limoges.

How many clinical trials are recruiting in Limoges?

179 of the 325 studies on this page are recruiting new participants as of the 29 Oct 2026, 03:20 UTC sync. A further 30 have not yet opened recruitment, 114 are active but closed to new participants, and 2 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Limoges), 325 studies
Phase	Studies	Recruiting	Share
Phase 3	109	50	33.5%
Not applicable	78	52	24%
Observational	58	33	17.8%
Phase 2	55	26	16.9%
Phase 2/3	9	5	2.8%
Phase 4	8	7	2.5%
Phase 1/2	5	4	1.5%
Phase 1	3	2	0.9%

Most active sponsors

Lead sponsors with the most studies (Limoges)
Lead sponsor	Studies	Recruiting
University Hospital, Limoges	41	26
Merck Sharp & Dohme LLC	18	8
AstraZeneca	12	5
Janssen Research & Development, LLC	11	2
University Hospital, Bordeaux	11	7
Hoffmann-La Roche	8	4
Institut Claudius Regaud	8	7
Assistance Publique - Hôpitaux de Paris	7	4
Centre Hospitalier Esquirol	7	5
University Hospital, Toulouse	7	3

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.