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Clinical Trials in France / NCT04858555
Active, not recruiting Observational

Staging System in Amyotrophic Lateral Sclerosis

NCT04858555 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Limoges
Phase
Observational
Started
2022-12-02
Last updated
2026-06-26

Condition(s) studied

Amyotrophic Lateral Sclerosis

Study summary

Recently two staging systems have been proposed for amyotrophic lateral sclerosis (ALS), based on clinical milestones The King's college clinical staging system (1) and ALS Milano-Torino Staging (ALS-MITOS) (2). Further research to validate and develop an accurate staging system in different populations will improve our understanding of its pathogenesis, disease activity and progression.

General objective : To validate the two previously proposed staging system and to test the interest of considering Neurofilament biomarkers in these systems.

Specific objectives: 1) To validate the two classification systems in an independent cohort of patients with ALS followed-up in the ALS expert center of Limoges (France) 2) To assess the interest of Nf biomarkers to predict neurological decline

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * ALS cases recruited for retrospectively (between) 2007 to 2016 for the retrospective cohort * ALS cases recruited for prospectively by the ALS expert center of Limoges for one year. Exclusion Criteria: * Previous neurosurgical operations * A recent history of neurotrauma * Peripheral neuropathies * ALS/frontotemporal dementia (ALS/FTD)

Primary outcome measure(s)

Trial sites (2)

FacilityCityRegionStatus
Limoges University Hospital Limoges France
Tours University Hospital Tours France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04858555 on ClinicalTrials.gov ↗ ← All trials in France