Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

measurement of the peripheral perfusion index and marbling assessment: in addition to the classic hemodynamic parameters measured in all patients, a measurement of the peripheral perfusion index (from 1 sec to 10 sec) and marbling assessment (scale from 0 to 5) will be performed

Study summary

Despite early treatment, the deterioration and mortality of sepsis patients remains high. A possible explanation could be persistent tissue hypoperfusion, or undetected in the early phase despite the normalization of macro-hemodynamic parameters. This interventional study evaluates the impact of measuring microcirculation parameters by nurses on patient prognosis through early initiation of vascular filling.

Eligibility

Primary outcome measure(s)

• Number and proportion of patients presenting clinical deterioration during emergency care — between time of inclusion and 24 hours after
  Clinical deterioration is defined by (composite criterion): 1. Arterial hypotension defined by systolic blood pressure (SBP) ≤ 100 mmHg 2. Implementation of treatment for organ support: * Vasopressor or inotrope * Invasive ventilation 3. Abnormal lactate concentration (\> 2mmol/L), without improvement (absence of decay) 4. Patient admitted in intensive care unit 5. Death

Trial sites (6)

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