Clinical trial register · Czechia

Clinical Trials in Prague, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Czechia and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 1513 matching records held by the registry are in this view. Synced 11 Nov 2026, 03:18 UTC

1513

Studies in scope

all four open statuses

780

Recruiting now

open to new participants

300

Lead sponsors

across recruiting studies

Top sites

Prague 1080 Brno 610 Hradec Králové 323 Olomouc 313 Ostrava 282

Trials with a site in Prague

Status

Study

Lead sponsor

Phase

Enrol

Sites in Czechia

Start

Not yet open

An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy

NCT07789483Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

DrugCliramitug

Alexion Pharmaceuticals, Inc.

Phase 3

1,180

Praha, Prague

2027-11-23

Not yet open

Exercise-Based Strategies for Chronic Back Pain

NCT07475481Chronic Low-back Pain (cLBP)

Charles University, Czech Republic

Not applicable

120

Prague

2027-07-01

Not yet open

The Evaluation of User Experience With FARAVIEW™ Technology of the OPAL HDx™ Mapping System When Used With the FARAWAVE NAV™ ULTRA Pulsed Field Ablation Catheter in the Treatment of Atrial Fibrillation

NCT07925359Atrial Fibrillation (AF), Paroxysmal AF, Persistent Atrial Fibrillation (PersAF), FARAPULSE

Boston Scientific Corporation

Not applicable

200

Prague

2027-01-20

Not yet open

A Study to Learn How Well People With Bronchiectasis Tolerate Continued Treatment With Verducatib After Earlier Studies (AIRTIVITY®-ON)

NCT07915219Bronchiectasis

DrugVerducatib

Boehringer Ingelheim

Phase 3

1,500

Jindřichův Hradec, Prague

2027-01-11

Not yet open

Multimodal Therapy for Somatosensory Tinnitus

NCT07468318Ear Noise, Tinnitus, Noise Induced, Tinnitus, Subjective, Headache Other

Charles University, Czech Republic

Not applicable

160

Prague

2027-01-01

Recruiting

Standardized 4D Transperineal Ultrasound Assessment of Urethrovesical Junction Mobility After Vaginal Laser Treatment for Stress Urinary Incontinence.

NCT07907016Urinary Incontinence , Stress, Laser Therapy

Charles University, Czech Republic

Observational

Prague

2027-01-01

Not yet open

Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO

NCT07499037Pneumonia, Heart Failure

University Hospital Ostrava

Phase 2

200

Ostrava, Prague

2027-01

Not yet open

A Study to Understand How Nerandomilast Works in People With Active Idiopathic Inflammatory Myopathies

NCT07789015Idiopathic Inflammatory Myopathies

DrugNerandomilast

Boehringer Ingelheim

Phase 3

270

Prague

2026-12-14

Not yet open

Efficacy of Progesterone and Low Molecular Weight Heparin in Recurrent Pregnancy Loss

NCT07796737Pregnancy Loss, Pregnancy Loss, Early

DrugsVaginal Micronized Progesterone·Enoxaparin

General University Hospital, Prague

Phase 3

268

Prague

2026-12-01

Not yet open

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk

NCT07900633Obesity, Overweight, Cardiovascular Diseases, Diabetes Mellitus, Type 2

DrugEloralintide

Eli Lilly and Company

Phase 3

3,000

Náchod, Nový Jičín, Prague, Roudnice nad Labem, Ústí nad Labem

2026-12

Not yet open

PREterm Infants With Bronchial Obstruction - Prospective Study of Efficacy and Safety of Inhaled Tiotropium

NCT07827859Bronchial Obstruction, Premature Birth

General University Hospital, Prague

Phase 4

Prague

2026-11-01

Not yet open

A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder

NCT07772531Major Depressive Disorder

Bristol-Myers Squibb

Phase 2

200

Prague, Kladno, Klecany, Pilsen

2026-10-30

Recruiting

Cervical Stiffness in Women With Threatened Preterm Labor

NCT07840235Preterm Labor, Preterm Birth

Pregnolia AG

Observational

100

Prague

2026-10-15

Not yet open

Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders

NCT07903142Low Back Pain, Radicular Syndrome, Sacroiliac Joint Dysfunction, Shoulder Impingement Syndrome

BTL Industries Ltd.

Not applicable

Prague

2026-10-15

Not yet open

Pilot Study of Individualized Neurovisual Rehabilitation Following Acquired Brain Injury

NCT07849582Brain Injuries

Charles University, Czech Republic

Not applicable

Prague

2026-10-15

By invitation

Visual Impairment and Functional Visual Performance Following Acquired Brain Injury: A Cross-Sectional Study

NCT07858708Vision Disorder, Stroke, Brain Injuries

Charles University, Czech Republic

Observational

108

Prague

2026-10

Recruiting

Bexmarilimab + Azacitidine Versus Placebo + Azacitidine in Participants With Treatment-naïve Higher-risk Myelodysplastic Syndromes

NCT07672769Higher Risk Myelodysplastic Syndromes

DrugsBexmarilimab·Azacitidine

Faron Pharmaceuticals Ltd

Phase 2

Brno, Hradec Králové, Ostrava-Poruba, Prague

2026-10

Not yet open

Exercise Snacks Enabled by an mHealth Intervention Delivered in General Practice to Promote a Sustainable Active Lifestyle in Adults With Obesity

NCT07867665Obesity, Physical Inactivity, Sedentary Behavior

Charles University, Czech Republic

Not applicable

306

Ostrava, Prague

2026-10

Recruiting

Evaluation of the DuoVT PFA System for Ventricular Tachycardia

NCT07706712Ventricular Tachycardia

Abbott Medical Devices

Not applicable

Prague

2026-09-29

Recruiting

The Effect of Urolithin A (Mitopure®) on Alzheimer's Disease

NCT07842146Alzheimer's Disease (AD), Early Alzheimer's Disease, Mild Cognitive Impairment Due to Alzheimer's Disease

University Hospital, Akershus

Not applicable

Prague

2026-09-26

Recruiting

A Study to Investigate the Efficacy and Safety of Alpha1H as a Neoadjuvant Therapy in Participants With Low- to Intermediate-Risk/Low-Grade Papillary Non-Muscle Invasive Bladder Cancer

NCT07804056Urinary Bladder Neoplasms, Non-muscle Invasive Bladder Cancer (NMIBC)

Hamlet Pharma AB

Phase 3

194

Prague

2026-09-17

Recruiting

Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies

NCT07648264Secondary Immune Deficiency

DrugHizentra

CSL Behring

Phase 3

Ostrova, Hradec Králové, Prague

2026-09-15

Recruiting

A Study in Adults With Geographic Atrophy

NCT07606365Geographic Atrophy

DrugSTL303

Sitala Bio LTD

Phase 2

300

Pardubice, Prague

2026-09-11

Recruiting

A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib

NCT07623161Myelofibrosis, Anemia

DrugElritercept

Takeda

Phase 3

324

Brno, Hradec Králové, Prague

2026-09-10

Recruiting

Magnet System Gastric Outlet Obstruction Study

NCT07609511Gastric Outlet Obstruction

GT Metabolic Solutions, Inc.

Not applicable

Prague

2026-09-09

Recruiting

A Study of Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) or Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With NDMM For Whom Stem Cell Transplant is Not Planned

NCT07665450Multiple Myeloma

DrugsRamantamig·Bortezomib·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,000

Brno, Hradec Králové, Ostrava, Pilsen, Prague

2026-09-09

Recruiting

A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia

NCT07623200Essential Thrombocythemia

DrugINCA033989

Incyte Corporation

Phase 3

426

Brno, Ostrava-poruba, Prague

2026-09-08

Not yet open

A Precision Medicine Trial for Patients With Relapsed or Refractory T Cell ALL

NCT07522801LAL

DrugsEnrylaze·Tofacitinib·Azacitidine·Venetoclax

Philippe ROUSSELOT

Phase 2

Brno, Prague

2026-09-01

Not yet open

Feasibility and Preliminary Effects of a Structured Resistance Training Program in Children Aged 10-14 Years

NCT07512570Muscle Architecture, Ultrasonic Diagnosis

Charles University, Czech Republic

Not applicable

Prague

2026-09-01

Recruiting

International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 (IntReALL BCP 2020)

NCT07476729B-Cell Acute Lymphoblastic Leukaemia

DrugsInotuzumab Ozogamicin·Blinatumomab

Charite University, Berlin, Germany

Phase 3

750

Prague

2026-09-01

Recruiting

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

NCT07743463Obesity, Overweight, Chronic Weight Management

DrugASC30 A1

Ascletis Pharma (China) Co., Limited

Phase 3

3,003

Pardubice, Prague, Uherské Hradiště

2026-08-31

Recruiting

Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment

NCT07691970Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

1,072

Prague

2026-08-31

Recruiting

A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis

NCT07845487Ulcerative Colitis (UC), Severe Ulcerative Colitis, Moderate Ulcerative Colitis

DrugPALI-2108

Palisade Bio

Phase 2

204

Brno, Havířov, Hradec Králové, Prague, Slaný

2026-08-28

Recruiting

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

NCT07743450Obesity, Overweight, Chronic Weight Management, Type 2 Diabetes Mellitus

DrugASC30 A1

Ascletis Pharma (China) Co., Limited

Phase 3

1,560

Pardubice, Prague, Uherské Hradiště

2026-08-28

Recruiting

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

NCT07794579Overweight, Prediabetic State, Prehypertension, Obesity, Abdominal

DrugOrforglipron

Eli Lilly and Company

Phase 3

2,001

Brno, České Budějovice, Habry, Ostrava, Prague, Praha 9 - Klanovice, Uherské Hradiště

2026-08-26

Recruiting

A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus

NCT07784725Obesity or Overweight

DrugLenbelintide

AstraZeneca

Phase 3

2,500

Benešov, Brandýs nad Labem, Brno, Hodonín, Kladno, Ostrava, Prague, Štětí

2026-08-19

Recruiting

A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

NCT07759245Pulmonary Disease, Chronic Obstructive

DrugBrenipatide

Eli Lilly and Company

Phase 2

606

Jindichv Hradec, Miroslav, Ostrava, Prague

2026-08-07

Recruiting

CanRisk-Based Ovarian Cancer Risk Assessment Versus Standard Practice (DISARM CSA)

NCT07809659Ovarian Cancer

Instituto Portugues Oncologia de Lisboa Francisco Gentil

Not applicable

2,130

Prague

2026-08-06

Recruiting

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study

NCT07746895C3 Glomerulopathy (C3G), Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)

DrugPegcetacoplan

Swedish Orphan Biovitrum

Phase 4

150

Prague

2026-08-05

Recruiting

Innovative Ovarian Cancer Biomarker Assays

NCT07693894Ovarian Cancer

National and Kapodistrian University of Athens

Observational

2,080

Prague

2026-08-03

Recruiting

Intracardiac Echocardiography-guided Versus Electroanatomical Mapping-guided Pulsed Field Ablation for Paroxysmal Atrial Fibrillation

NCT07772518Paroxysmal Atrial Fibrillation (PAF)

Mitera Hospital

Not applicable

292

Prague

2026-08-01

Recruiting

Impact of Ultra-Processed Food Reduction on Remission Duration in Pediatric Crohn's Disease

NCT07884045Crohn Disease (CD)

University Hospital, Motol

Not applicable

124

Prague

2026-08-01

Recruiting

A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)

NCT07742735Short Bowel Syndrome (SBS), SBS Associated With Intestinal Failure (SBS-IF)

DrugApraglutide

VectivBio AG

Phase 3

124

Brno, Hradec Králové, Prague

2026-08

Recruiting

Evaluation of the Efficacy and Safety of Magnetic Resonance Angiography (MRA) Using Gadopiclenol Compared to Gadoterate Meglumine in the Assessment of Steno-occlusive Disease in Adult Patients With Suspected Vascular Disease

NCT07348640Steno-occlusive Disease

DrugGadoterate meglumine

Guerbet

Phase 3

315

Brno, Prague

2026-07-28

Recruiting

A Study on the Acquisition of 2D ICE Images With the CHORUS IDx System in Subjects Undergoing an Ablation Procedure

NCT07353710Atrial Arrhythmia, Intracardiac Echocardiography

Boston Scientific Corporation

Not applicable

200

Prague

2026-07-28

Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

NCT07497087Systemic Sclerosis

Boehringer Ingelheim

Phase 3

448

Brno, Prague

2026-07-27

Recruiting

A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)

NCT07366034Fibrosing Interstitial Lung Disease

DrugNerandomilast

Boehringer Ingelheim

Phase 3

Prague

2026-07-21

Recruiting

An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

NCT07234032Pulmonary Hypertension, Interstitial Lung Disease

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 3

344

Prague

2026-07-20

Recruiting

Toric Performance And Constant Evaluation

NCT07471295Cataract

Carl Zeiss Meditec AG

Phase 4

130

Prague

2026-07-13

Recruiting

An Extension Study to Assess Safety and Efficacy of Remibrutinib in Participants With Moderate to Severe HS

NCT07665437Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

710

Prague

2026-07-10

Recruiting

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin

NCT07664553Type 2 Diabetes Mellitus

DrugElecoglipron

AstraZeneca

Phase 3

600

Broumov, České Budějovice, Ostrava, Pilsen, Prague

2026-07-08

Recruiting

A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus

NCT07662109Type 2 Diabetes Mellitus

DrugsElecoglipron·Dapagliflozin

AstraZeneca

Phase 3

2,000

Hradec Králové, Humpolec, Jílové u Prahy, Ostrava, Prague, Příbram

2026-07-06

Not yet open

Midwife-led Childbirth Review and Psychological Outcomes in New Parents

NCT07678801Postpartum Depression (PPD), Perinatal Anxiety, Postpartum Mental Health

Charles University, Czech Republic

Not applicable

1,300

Brno, Prague

2026-07-06

Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

NCT07630974Malignant Neoplasm

DrugIfinatamab Deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

134

Prague

2026-07-06

Recruiting

Pediatric Artificial Intelligence for Retinopathy Screening in Children With Type 1 Diabetes

NCT07149142Type 1 Diabetes Mellitus

University Hospital, Motol

Not applicable

400

Prague

2026-07-01

Recruiting

Stroke Care During the COVID-19 Pandemic

NCT07795021Stroke (CVA) or TIA

Dr. Yaroslav Winter

Observational

40,000

Prague

2026-07-01

Not yet open

Comprehensive Rehabilitation Programme in People With Multiple Sclerosis: The RECONNECT-MS Study

NCT07666958Multiple Sclerosis

Charles University, Czech Republic

Not applicable

Prague

2026-07-01

Recruiting

Pridopidine Phase 3 Study in Huntington's Disease

NCT07609108Huntington Disease

DrugPridopidine

Prilenia

Phase 3

400

Prague

2026-07-01

Recruiting

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction

NCT07403058Heart Failure With Reduced Ejection Fraction (HFrEF)

Axon Therapies, Inc.

Not applicable

Prague

2026-06-12

Recruiting

Open Label Extension to Assess Long Term Safety and Efficacy of KL1333 in Patients With Primary Mitochondrial Disease

NCT07514338Mitochondrial Diseases

DrugNapazimone

Pharming Technologies B.V.

Phase 2

140

Prague

2026-06-12

Recruiting

IGNITE: Study of Tirabrutinib vs Rituximab and Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

NCT07104032Relapsed/Refractory Primary Central Nervous System Lymphoma

DrugsTirabrutinib·Temozolomide·Rituximab

Ono Pharmaceutical Co., Ltd.

Phase 3

132

Ostrava, Prague

2026-06-12

Recruiting

Supporting Weak Immune System During Autoimmune Therapy: Testing Panzyga to Prevent Infections

NCT07220915Hypogammaglobulinemia, Autoimmune Conditions, Rheumatic Conditions, Infections

DrugPanzyga

Octapharma

Phase 3

360

Prague, Hradec Králové, Pardubice

2026-06-10

Recruiting

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

NCT07519902Persistent Corneal Epithelial Defect

DrugCenegermin

Dompé Farmaceutici S.p.A

Phase 3

150

Prague

2026-06-02

Recruiting

Extended Ablation Versus Pulmonary Vein Isolation to Treat Persistent Atrial Fibrillation

NCT07424326Atrial Fibrillation (AF)

Charles University, Czech Republic

Not applicable

450

Olomouc, Prague

2026-06-01

Recruiting

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

NCT07192952Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)

DrugFinerenone

Bayer

Phase 3

117

Prague, Brno

2026-06-01

Recruiting

Middle Meningeal Artery Embolisation in Chronic Subdural Hematoma

NCT07751887Chronic Subdural Hematoma

University Hospital Hradec Kralove

Not applicable

200

České Budějovice, Hradec Králové, Liberec, Olomouc, Prague

2026-06-01

Recruiting

A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT07518186Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

700

Brno, Hradec Králové, Ostrava, Plzen-Lochotin, Prague

2026-05-31

Recruiting

A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis

NCT07599813Atopic Dermatitis, Atopic, Dermatitis, Dermatitis, Atopic

Apollo Therapeutics Ltd

Phase 2

280

Ostrava, Pardubice, Prague

2026-05-28

Recruiting

A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration

NCT07614776Neovascular Age-related Macular Degeneration, nAMD

Amgen

Phase 3

304

Náchod, Ostrava - Poruba, Prague, Mladá Boleslav

2026-05-27

Recruiting

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

NCT07357727Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (PPV-MF), Post-essential Thrombocythemia Myelofibrosis (PET-MF)

DrugsPelabresib·Ruxolitinib

Novartis Pharmaceuticals

Phase 3

460

Ostrava, Brno, Hradec Králové, Olomouc, Prague

2026-05-27

Recruiting

BIO|STREAM.CSP Study

NCT07393009Cardiac Pacing, Cardiac Pacemaker, Implantable Cardioverter Defibrillator, Cardiac Resynchronization Therapy Devices

Biotronik SE & Co. KG

Observational

1,000

Olomouc, Prague

2026-05-25

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis

NCT07577856Colitis, Ulcerative

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

644

Brno, České Budějovice, Hradec Králové, Kladno, Ostrava, Prague

2026-05-23

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease

NCT07577843Crohn Disease

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

460

Hradec Králové, Kladno, Ostrava, Prague

2026-05-22

Recruiting

Safety, Tolerability, Pharmacokinetics, and Efficacy of Filgotinib for the Treatment of Polyarticular-course Juvenile Idiopathic Arthritis in Children and Adolescents

NCT07554495Polyarticular Course Juvenile Idiopathic Arthritis

DrugFilgotinib

Alfasigma S.p.A.

Phase 3

Prague

2026-05-21

Recruiting

RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive

NCT07413939HER2-positive Breast Cancer

DrugsZN-A-1041·Tucatinib·Trastuzumab·Capecitabine

Hoffmann-La Roche

Phase 2/3

650

Brno, Hradec Králové, Nový Jičín, Prague

2026-05-21

Recruiting

A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

NCT07564414Obesity, Type 2 Diabetes

DrugsCagriSema·Semaglutide

Novo Nordisk A/S

Phase 3

2,500

Brno, Dolní Břežany, Liberec, Náchod, Plzeň 3, Prague

2026-05-21

Recruiting

Optimal Shock Energy for Electrical Cardioversion of Atrial Fibrillation

NCT07610980Atrial Fibrillation (AF)

Motol and Homolka University Hospital

Not applicable

400

Prague

2026-05-18

Recruiting

A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis

NCT07387549Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 3

350

Pilsen, Prague

2026-05-14

Recruiting

Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica

NCT07286214Polymyalgia Rheumatica

DrugSarilumab

Sanofi

Phase 3

300

Hlučín, Ostrava, Prague, Uherské Hradiště, Zlín

2026-05-12

Recruiting

Long-Acting Cabotegravir and Rilpivirine in People Living With HIV-1 Subtype A6: A Real-World Retrospective Study

NCT07370649Human Immunodeficiency Virus (HIV)-1 Infection, HIV-1 Subtype A6 Infection, HIV-1 Subtype B Infection, Virologically Suppressed HIV-1 Infection Receiving Long-Acting Antiretroviral Therapy

DrugCabotegravir

Pomeranian Medical University Szczecin

Observational

250

Prague

2026-05-12

Recruiting

FEMART-1 Pilot Study

NCT07596446Sudden Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA), Cardiogenic Shock Acute

Emergency Medical Service, Prague

Not applicable

Prague

2026-05-11

Recruiting

Monopolar Basivertebral Nerve Ablation for Axial Low Back Pain

NCT07559890Chronic Back Pain, Basivertebral Nerve Ablation

EPC Education s.r.o.

Not applicable

100

Prague

2026-05-04

Not yet open

Reduction of Muscle Catabolism Through Brain Activation in Burn Patients

NCT07435402Burns - Multiple, Critical Illness, Muscle Weakness

Charles University, Czech Republic

Not applicable

Prague

2026-05-01

Recruiting

Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic

NCT07432009Frailty, Cognitive Impairment, Older Adults, Hip Arthroplasty

Tomas Bata Hospital, Czech Republic

Observational

400

Brno, Olomouc, Ostrava, Prague, Vsetín, Zlín

2026-04-24

Recruiting

Fermented Foods and Bone Health: Investigating the Gut-Bone Axis in Premenopausal Vegan Women

NCT07645885Bone, Bone Health

Isabelle Herter-Aeberli

Not applicable

Prague

2026-04-23

Recruiting

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

NCT07499232Crohn Disease

DrugsRisankizumab·Guselkumab

Janssen Research & Development, LLC

Phase 3

530

Brno, Hradec Kralova, Hradec Králové, Ostrava-Poruba, Prague

2026-04-21

Recruiting

Visugromab in Cachexia International Trial

NCT07112196Cancer-associated Cachexia

DrugVisugromab

CatalYm GmbH

Phase 2/3

518

Hořovice, Hradec Králové, Olomouc, Prague

2026-04-16

Recruiting

Remibrutinib Open Label Roll-over Post-trial Access Protocol

NCT07456891Indication of the Parent Protocol

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

650

Brno, Plzen Bolevec, Prague

2026-04-16

Recruiting

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

NCT07496567Macular Degeneration, Age-Related Macular Degeneration, Choroidal Neovascularization, Wet Macular Degeneration

DrugsTiespectus·Eylea·Aflibercept

EyeBiotech Ltd.

Phase 2/3

960

Mladá Boleslav, Náchod, Prague

2026-04-15

Not yet open

Neuroproprioceptive Equine-Assisted Physiotherapy for Spinal Muscular Atrophy

NCT07336602Spinal Muscular Atrophy (SMA)

Charles University, Czech Republic

Not applicable

Bohuslavice, Jihlava, Prague

2026-04-15

Recruiting

A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma

NCT07525375Asthma

AstraZeneca

Phase 2

Brno, Prague

2026-04-14

Recruiting

DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy

NCT07472517Small Cell Lung Cancer (SCLC), Extensive-stage Small Cell Lung Cancer (ES-SCLC)

DrugsObrixtamig·Etoposide·Atezolizumab·Carboplatin

Boehringer Ingelheim

Phase 3

670

Olomouc, Prague

2026-04-13

Recruiting

Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumors

NCT07536087Endoscopic Ultrasound-Guided Radiofrequency Ablation, Pancreatic Neuroendocrine Tumors (pNET), Pancreatic Cystic Neoplasms

Institute for Clinical and Experimental Medicine

Not applicable

Prague

2026-04-11

Recruiting

A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)

NCT07489495Carcinoma, Renal Cell

DrugsZanzalintinib·Belzutifan

Merck Sharp & Dohme LLC

Phase 3

758

Brno, Ostrava, Hradec Králové, Olomouc, Prague

2026-04-09

Recruiting

Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

NCT07298473Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)

Medtronic Cardiac Ablation Solutions

Not applicable

400

Prague

2026-04-08

Recruiting

Safety and Effectiveness of Orbera365™ Intragastric Balloon System

NCT07062094Obesity

Boston Scientific Corporation

Observational

200

Prague

2026-04-07

Recruiting

NS-PFA Catheter Ablation of Paroxysmal Atrial Fibrillation With the Pulse Biosciences CellFX System

NCT07018596Atrial Fibrillation Paroxysmal, Cardiac Ablation, Cardiac Arrhythmia

Pulse Biosciences, Inc.

Not applicable

215

Prague

2026-04-06

Recruiting

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

NCT07527156Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones

Institute for Clinical and Experimental Medicine

Phase 4

Prague

2026-04-04

Recruiting

Confirmatory Clinical Study in Active Ulcerative Colitis

NCT07296315Colitis, Ulcerative

MRM Health NV

Phase 2

204

Brno, Prague

2026-04-03

Recruiting

Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)

NCT07428499Hereditary Angioedema (HAE), Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2, HAE

ADARx Pharmaceuticals, Inc.

Phase 3

Hradec Králové, Prague

2026-04-02

Recruiting

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)

NCT07355218Systematic Lupus Erythematosus, Cutaneous Lupus Erythematosus

DrugEnpatoran

EMD Serono Research & Development Institute, Inc.

Phase 3

202

Brno, Prague, Uherské Hradiště

2026-04-01

Not yet open

Menstrual Cycle and Women's Performance

NCT07462286Menstrual Cycle, Physical Performance, Muscle Strength, Musculoskeletal System

Charles University, Czech Republic

Observational

Prague

2026-04-01

Recruiting

Deep Endometriosis Affecting the Urogenital Tract: Long-term Outcomes and Impact on Renal Function

NCT07776574Endometriosis, Endometriosis (Diagnosis), Urinary Tract Diseases

Charles University, Czech Republic

Observational

Prague

2026-04-01

Recruiting

Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration

NCT07523620Atrial Fibrillation (AF), Paroxysmal AF, Persistent Atrial Fibrillation

Abbott Medical Devices

Not applicable

240

Prague

2026-03-31

Recruiting

InRAD Observational Study

NCT07213700Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Non-Alzheimer Degenerative Dementia

Stichting International Registry for Alzheimer's Disease and other Dementias Foundation

Observational

50,000

Prague

2026-03-30

Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Other Agents in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)

NCT07293351Advanced Renal Cell Carcinoma (RCC)

DrugsCasdatifan·Pumitamig·Cabozantinib·Yervoy

Bristol-Myers Squibb

Phase 1/2

474

Prague, Brno, Hradec Králové

2026-03-26

Recruiting

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

NCT07415044Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe

DrugZotemtegrast

Eli Lilly and Company

Phase 2

1,431

Hradec Králové, Pardubice, Prague, Slaný, Sternberk, Uherské Hradiště, Vsetín

2026-03-26

Recruiting

A Study to Assess the Effects of Zigakibart on IgA Nephropathy.

NCT07146906Immunoglobulin A Nephropathy (IgAN)

DrugZigakibart

Novartis Pharmaceuticals

Phase 2

Prague

2026-03-26

Recruiting

A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

NCT07326709Huntington Disease

DrugVotoplam

Novartis Pharmaceuticals

Phase 3

770

Brno, Prague

2026-03-24

Recruiting

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

NCT07351058Obesity or Overweight, Type 2 Diabetes Mellitus

Hoffmann-La Roche

Phase 3

1,600

Brandýs nad Labem, Jesenice, Prague, Praha 9 - Klánovice

2026-03-23

Recruiting

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

NCT07351045Obesity or Overweight

Hoffmann-La Roche

Phase 3

2,000

České Budějovice, Náchod, Plze?, Prague

2026-03-16

Recruiting

A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation

NCT07412470Kidney Transplant Rejection

DrugsRabbit anti-thymocyte globulin·Frexalimab·Mycophenolate Mofetil·Tacrolimus

Sanofi

Phase 2/3

526

Ostrava, Prague

2026-03-13

Active, closed

An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps

NCT07424144Chronic Rhinosinusitis With Nasal Polyps

DrugItepekimab

Sanofi

Phase 3

Hradec Králové, Pardubice, Prague

2026-03-12

Recruiting

Continuation Study of Zasocitinib in Adults With Psoriatic Arthritis

NCT07286058Psoriatic Arthritis

DrugZasocitinib

Takeda

Phase 3

1,182

Ostrava, Pardubice, Prague, Uherské Hradiště, Zlín

2026-03-11

Recruiting

A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

NCT07441642Geographic Atrophy Secondary to Age-related Macular Degeneration

Novartis Pharmaceuticals

Phase 2

272

Prague

2026-03-09

Recruiting

A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

NCT07438496Lupus Erythematosus, Systemic

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

600

Brno, Karvina Frystat, Prague

2026-03-05

Active, closed

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

NCT07288398Pulmonary Hypertension Associated With HFpEF

DrugTNX-103

Tenax Therapeutics, Inc.

Phase 3

540

Ostrava, Prague

2026-03-03

Recruiting

Evaluation of SaCoVLM™ Video Laryngeal Mask for Airway Management in Military Medics

NCT07249983Airway Management, Tracheal Intubation, Anesthesia

Charles University, Czech Republic

Not applicable

Prague

2026-03-01

Recruiting

Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide

NCT07454837Chronic Hepatitis D

DrugBulevirtide

Mirum Pharmaceuticals, Inc.

Phase 2/3

120

Brno, Prague

2026-02-26

Active, closed

A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

NCT07400653Obesity, Overweight and/or Obesity, Overweight, Diabetes, Type 2

DrugBerobenatide

Pfizer

Phase 3

1,078

Brandys Nad Lebem, Náchod, Ostrava, Pardubice, Prague

2026-02-24

Recruiting

A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

NCT07318558Ovarian Neoplasms, Ovarian Cancer

DrugsMvasi·Sacituzumab tirumotecan·Avastin·Bevacizumab

Merck Sharp & Dohme LLC

Phase 3

900

Brno, Ostrava-Poruba, Hradec Králové, Prague

2026-02-16

Recruiting

Evaluation of Novel Waveforms Delivered Using the FARAPULSE™ PFA System

NCT07444320Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation

Boston Scientific Corporation

Not applicable

200

Prague

2026-02-12

Recruiting

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease

NCT07363694Moderate to Severe Chronic Obstructive Pulmonary Disease

Pfizer

Phase 2/3

1,156

Brandýs nad Labem-Stará Boleslav, Jindřichův Hradec, Mladá Boleslav, Prague, Varnsdorf

2026-02-11

Recruiting

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

NCT07215702Sepsis, Acute Kidney Injury

DrugAZD4144

AstraZeneca

Phase 2

124

Brno, Kolín, Prague

2026-02-10

Recruiting

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

NCT07392190Overweight, Obesity

DrugEloralintide

Eli Lilly and Company

Phase 3

900

Holešov, Prague

2026-02-10

Active, closed

CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

NCT07449923Diabetic Macular Edema, DME, Diabetic Macular Edema (DME)

DrugsEYP-1901·Aflibercept

EyePoint Pharmaceuticals, Inc.

Phase 3

240

Náchod, Prague, Sokolov

2026-02-09

Recruiting

A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)

NCT07222332Diabetes Mellitus, Type 1

DrugBaricitinib

Eli Lilly and Company

Phase 3

300

Jihlava, Ostrava, Prague

2026-02-05

Recruiting

Early Detection of Skin Tumors Using a Telemedicine Tool in Primary Care

NCT07349940Skin Cancer Prevention, Melanoma In Situ, Skin Lesions, Skin Cancer

Institute of Health Information and Statistics of the Czech Republic

Not applicable

1,440

Brno, Olomouc, Pilsen, Prague

2026-02-01

Recruiting

HPV After chemoRadioTherapy

NCT07493928Cervical Cancer Recurrent, Radiotherapy, Cell Free DNA, HPV

General University Hospital, Prague

Observational

120

Prague

2026-02-01

Recruiting

Anatomical Navigation for Guided Electrophysiology in AFL and AFib

NCT07210151Atrial Fibrillation, Atrial Flutter, Atrial Arrhythmia

LUMA Vision Ltd.

Not applicable

Prague

2026-01-29

By invitation

A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD)

NCT07286006Graves' Disease

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

372

Prague, Náchod

2026-01-26

Recruiting

Neoadjuvant Darovasertib in Primary Uveal Melanoma

NCT07015190Uveal Melanoma

DrugDarovasertib

IDEAYA Biosciences

Phase 3

520

Prague

2026-01-25

Recruiting

A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia

NCT07277231Chronic Lymphocytic Leukemia

DrugsSonrotoclax·Acalabrutinib·Venclexta·Zanubrutinib

BeOne Medicines

Phase 3

500

Brno, Hradec Králové, Olomouc, Ostrava, PLZE, Prague

2026-01-22

Active, closed

Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis

NCT07332091Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

CSL Behring

Phase 2

Brno, Ostrava, Prague

2026-01-22

Recruiting

A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

NCT07184944Crohn's Disease

DrugDuvakitug

Sanofi

Phase 3

751

Hradec Králové, Prague

2026-01-22

Recruiting

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

NCT07216703Cervical Cancer

DrugsMvasi·Paraplatin·Sacituzumab tirumotecan·Avastin

Merck Sharp & Dohme LLC

Phase 3

1,023

Brno, Nový Jičín, Ostrava, Prague

2026-01-19

Active, closed

A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

NCT07321873Arthritis, Psoriatic

Janssen Research & Development, LLC

Phase 2

157

Břeclav, Hlučín, Karvina Frystat, Pardubice, Prague, Uherské Hradiště

2026-01-15

Recruiting

Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.

NCT07611721CGM, Intensive Care (ICU), Liver Transplant Surgery, Solid Organ Transplantation

Institute for Clinical and Experimental Medicine

Not applicable

Prague

2026-01-14

Recruiting

A Study of an IDH1m Inhibitor in Participants With IDH1-Mutated Malignancies and Hepatic or Renal Impairment

NCT07006688IDH1-Mutated Malignancies

DrugIvosidenib

Servier Bio-Innovation LLC

Phase 1

Prague, Brno, Ostrava

2026-01-14

Active, closed

Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

NCT07284901Obesity With Diabetes, Overweight With Diabetes

DrugRibupatide

Kailera

Phase 3

1,270

Brandýs nad Labem, Náchod, Trutnov, Bohnice, Prague, Brno, Holešov, Hodonín

2026-01-12

Recruiting

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

NCT07179380Pulmonary Hypertension, Interstitial Lung Disease

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 3

344

Prague

2026-01-07

Recruiting

Framework for Optimizing, Refining, and Unifying Management of HSCT in Pediatric ALL

NCT07297914Acute Lymphoblastic Leukemia (ALL), Stem Cell Transplant, Graft -Versus-host-disease

DrugsBlinatumomab·Cyclophosphamide

Bambino Gesù Hospital and Research Institute

Phase 2/3

1,000

Prague

2026-01-07

Recruiting

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT07222566Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)

DrugsPF-08634404·Pembrolizumab

Pfizer

Phase 3

1,410

Brno, Olomouc, Ostrava, Pardubice, Prague

2026-01-06

Recruiting

Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression

NCT07324070Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)

Charles University, Czech Republic

Not applicable

Prague

2026-01-05

Recruiting

A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation

NCT07219043Microvascular Inflammation

DrugFelzartamab

Biogen

Phase 2

Prague

2026-01-05

Recruiting

Single-center Evaluation of Human Milk Quantity and Quality Over Five Years

NCT07309146Lactating Women - Human Milk Donors

Charles University, Czech Republic

Observational

500

Prague

2026-01-01

Recruiting

Remimazolam-Fentanyl Mild Conscious Sedation Regimen in Pulsed-Field Ablation for Paroxysmal Atrial Fibrillation

NCT07734194Atrial Fibrillation (AF)

Charles University, Czech Republic

Observational

Prague

2026-01-01

Recruiting

Fertility Outcomes After Antibiotic Treatment In Women With Chronic Endometritis

NCT07603492Endometritis, Infertility, Hysteroscopy, Pregnancy Disease

Faculty Hospital Kralovske Vinohrady

Observational

100

Prague

2026-01-01

Not yet open

Time in rANge vs. Time in nOrmal Glycemia for Better Glycemic Control

NCT07376850Diabetes, Diabetes (DM), Diabetes Type 1

University Hospital, Motol

Not applicable

120

Prague

2026-01

Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

NCT07221357Untreated, Unresectable, or Metastatic Colorectal Cancer

DrugsPumitamig·Folfox·Bevacizumab

Bristol-Myers Squibb

Phase 2/3

990

Brno, Prague, Hradec Králové, Olomouc

2025-12-31

Recruiting

AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

NCT07218809Epithelial Ovarian Cancer

DrugsTorvutatug samrotecan·MIRV·Mirvetuximab Soravtansine·Pegylated liposomal doxorubicin

AstraZeneca

Phase 3

1,100

Brno, Hradec Králové, Nový Jičín, Olomouc, Prague

2025-12-29

Active, closed

A Dose-ranging Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Galvokimig in Adult Study Participants With Atopic Dermatitis

NCT07277660Atopic Dermatitis

DrugGalvokimig

UCB Biopharma SRL

Phase 2

165

Náchod, Prague

2025-12-29

Recruiting

Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)

NCT07482969Gastro Esophageal Reflux

University Hospital, Motol

Observational

1,000

Prague

2025-12-20

Active, closed

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

NCT07311850Obesity and Overweight

DrugBerobenatide

Pfizer

Phase 3

3,578

Brno, Náchod, Ostrava, Pardubice, Prague

2025-12-19

Active, closed

Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

NCT07284875Obesity, Overweight

DrugRibupatide

Kailera

Phase 3

2,530

Brandýs nad Labem, Náchod, Krnov, Bohnice, Prague, Brno, Hodonín, Olomouc

2025-12-18

Recruiting

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

NCT07300969Major Depressive Disorder (MDD)

DrugDT-101

Draig Therapeutics Ltd

Phase 2

300

Ostrava, Prague, Říčany

2025-12-16

Recruiting

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

NCT07282600Overweight, Obesity

DrugEloralintide

Eli Lilly and Company

Phase 3

1,035

Krnov, Ostrava, Prague

2025-12-15

Recruiting

LEAP 2 Chronic EFS

NCT07287423Cardiac Pacemaker, Cardiac Rhythm Disorder, Bradycardia

Abbott Medical Devices

Not applicable

Prague

2025-12-13

Recruiting

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

NCT07218380Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis

DrugsVepugratinib·Pembrolizumab

Eli Lilly and Company

Phase 3

450

Brno, Hradec Králové, Olomouc, Prague

2025-12-12

Recruiting

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

NCT06793397Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders

DrugCYB003

Cybin IRL Limited

Phase 3

330

Prague, Předměstí

2025-12-10

Not yet open

Comprehensive Therapeutic Program For People With Multiple Sclerosis

NCT07248657Multiple Sclerosis, Neurorehabilitation, Rehabilitation, Rehabilitation Exercise

Charles University, Czech Republic

Not applicable

Prague

2025-12-05

Recruiting

A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting

NCT07230691Carcinoma, Non-Small-Cell Lung

Janssen Research & Development, LLC

Observational

380

Brno, Hradec Králové, Olomouc, Prague

2025-12-03

Recruiting

A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)

NCT07276724Severe Asthma

DrugGB-0895

Generate Biomedicines

Phase 3

786

Varnsdorf, Jindřichův Hradec, Prague, Jablonec nad Nisou, Teplice

2025-12-03

Recruiting

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

NCT07276399Squamous Cell Carcinoma of Head and Neck

DrugsAmivantamab·Cisplatin·Carboplatin·Pembrolizumab

Janssen Research & Development, LLC

Phase 3

600

Hradec Králové, Olomouc, Ostrava, Prague, Zlín

2025-12-03

Recruiting

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

NCT06937229Alzheimer Disease, Agitation

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

650

Olomouc, Prague, Brno, Choceň, Pilsen, Rychnov nad Kněžnou

2025-12-02

Not yet open

Expiratory Muscle Training in Parkinson's Disease With Forward Trunk Flexion

NCT07268703Parkinson's Disease

General University Hospital, Prague

Not applicable

Prague

2025-12

Recruiting

A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

NCT06847542Neovascular Age-related Macular Degeneration

DrugRanibizumab

Hoffmann-La Roche

Phase 3

250

Mladá Boleslav, Ostrava, Prague

2025-11-27

Recruiting

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

NCT07227402Renal Cell Carcinoma

DrugsZanzalintinib·Belzutifan·Cabozantinib

Merck Sharp & Dohme LLC

Phase 3

904

Brno, Ostrava, České Budějovice, Hradec Králové, Olomouc, Prague

2025-11-26

Recruiting

PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS

NCT07142291Amyotrophic Lateral Sclerosis (ALS)

DrugsCromolyn Sodium·Riluzole

PhenoNet, Inc.

Phase 2

105

Hradec Králové, Prague

2025-11-25

By invitation

Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

NCT07256392Chronic Spontaneous Urticaria

DrugBarzolvolimab

Celldex Therapeutics

Phase 3

1,370

Prague

2025-11-25

Active, closed

A Study of KT-621 Administered Orally to Participants With Moderate to Severe Atopic Dermatitis

NCT07217015Atopic Dermatitis

DrugKT-621

Kymera Therapeutics, Inc.

Phase 2

200

Pardubice, Prague

2025-11-24

Recruiting

Proton-Based Total Marrow Irradiation for Allogeneic Transplantation in High-Risk AML/MDS

NCT07532824Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)/AML, Proton Therapy, MDS and AML Prior to Allogeneic SCT

Institute of Hematology and Blood Transfusion, Czech Republic

Phase 1/2

Prague

2025-11-21

Recruiting

A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema

NCT07216027Atopic Dermatitis, Eczema, Atopic

Pfizer

Phase 2

165

Náchod, Ostrava, Pardubice, Prague

2025-11-20

Recruiting

A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction

NCT07188805Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)

DrugFinerenone

Bayer

Phase 3

111

Brno, Prague

2025-11-19

Recruiting

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

NCT07228832Metastatic Colorectal Cancer (CRC)

DrugsIvonescimab·Leucovorin·Adrucil·Oxaliplatin

Summit Therapeutics

Phase 3

900

Brno, Hradec Králové, Olomouc, Prague

2025-11-18

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

NCT07059845Ovarian Cancer

DrugsMirvetuximab Soravtansine·Bevacizumab·Carboplatin

AbbVie

Phase 2

400

Brno, Prague, Hradec Králové

2025-11-13

Recruiting

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

NCT07225504Secondary Progressive Multiple Sclerosis (SPMS)

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

1,275

Brno, Hradec Králové, Jihlava, Prague, Teplice

2025-11-11

Active, closed

Phase 2a Study to Assess the Efficacy,Safety and Tolerability of GIA632 in Adult Participants With Moderate to Severe Atopic Dermatitis

NCT07220577Atopic Dermatitis

DrugGIA632

Novartis Pharmaceuticals

Phase 2

Ostrava, Brno, Prague

2025-11-10

Recruiting

Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

NCT06990269Geographic Atrophy Secondary to Age-related Macular Degeneration

ADARx Pharmaceuticals, Inc.

Phase 2

240

Prague, Praha Klanovice

2025-11-10

Recruiting

Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa

NCT07170917Hidradenitis Suppurativa

DrugBrivekimig

Sanofi

Phase 2

208

Ostrava, Prague

2025-11-06

Recruiting

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

NCT07007065Neovascular Age-related Macular Degeneration

DrugSurabgene Lomparvovec

AbbVie

Phase 3

561

Prague

2025-11-05

Active, closed

Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide

NCT07220759Overweight, Obesity, Type 2 Diabetes

DrugCagrilintide

Novo Nordisk A/S

Phase 3

330

České Budějovice, Prague

2025-11-05

By invitation

Risk Assessment of Mild Traumatic Brain Injury in Military Training

NCT06992570Trauma, Brain

Charles University, Czech Republic

Not applicable

Prague

2025-11-04

Active, closed

A Study Evaluating BFB759 in Moderate to Severe Hidradenitis Suppurativa

NCT07287644Hidradenitis Suppurativa (HS)

DrugBFB759

Bluefin Biomedicine, Inc.

Phase 2/3

210

Ostrava, Pardubice, Prague

2025-11-03

Recruiting

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

NCT07085767Breast Cancer, Locally Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Ribociclib·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

1,000

Hořovice, Liberec, Olomouc, Prague, Zlín

2025-11-03

Recruiting

LA Function After PFA in Paroxysmal AF

NCT07439016Atrial Fibrillation (AF)

Charles University, Czech Republic

Observational

Prague

2025-11-01

Active, closed

PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery

NCT07248527Pancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers

Charles University, Czech Republic

Observational

400

Prague

2025-11-01

Recruiting

Conservative vs Interventional Management of Postsurgical CSF Pseudomeningocele

NCT07614399CSF Leak, CSF Pressure Increased, CSF Circulation Disorder, Puncture

Charles University, Czech Republic

Not applicable

Prague

2025-11-01

Recruiting

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

NCT07173751Breast Neoplasms

DrugsEribulin·Pumitamig·Gemcitabine·Carboplatin

BioNTech SE

Phase 3

558

Nový Jičín, Pardubice, Prague

2025-10-30

Recruiting

Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

NCT06659445Geographic Atrophy (GA), Age - Related Macular Degeneration (AMD)

DrugAvacincaptad Pegol

ONL Therapeutics

Phase 2

324

Náchod, Prague, Sokolov

2025-10-28

Recruiting

Study to Evaluate the Efficacy and Safety of Oral Rilzabrutinib in Adults With Immune Thrombocytopenia (ITP) Who Failed First-line Treatment

NCT07007962Immune Thrombocytopenia

DrugRilzabrutinib

Sanofi

Phase 3

Prague

2025-10-24

Active, closed

A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

NCT07076121Pancreatic Ductal Adenocarcinoma

DrugsNavlimetostat·Abraxane·Nab-paclitaxel·Gemcitabine

Bristol-Myers Squibb

Phase 2/3

470

Brno, Hradec Králové, Olomouc, Prague

2025-10-23

Recruiting

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

NCT07213804Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis

DrugsSofe-M·MIRV·Pegylated liposomal doxorubicin·Topotecan

Eli Lilly and Company

Phase 3

1,630

Brno, Nový Jiín, Olomouc, Prague, Zlín

2025-10-22

Recruiting

A Study of JNT-517 in Participants With Phenylketonuria (PKU)

NCT06971731Phenylketonuria

DrugRepinatrabit

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 3

120

Prague

2025-10-20

Recruiting

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

NCT07165028Metabolic Dysfunction-Associated Steatotic Liver Disease

DrugsRetatrutide·Tirzepatide

Eli Lilly and Company

Phase 3

4,500

Liberec, Ostrava, Prague

2025-10-15

Active, closed

A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis

NCT07260669Endometriosis

Gesynta Pharma AB

Phase 2

213

Brno, Olomouc, Pilsen, Prague, Vodňany

2025-10-15

By invitation

Clinical Impact Through AI-assisted MS Care - A Prospective Multi-center Study

NCT07032246Multiple Sclerosis, Radiologically Isolated Syndrome, Clinically Isolated Syndrome

icometrix

Not applicable

750

Prague

2025-10-09

Recruiting

Unified Protocol for Emotional Disorders: HiTOP-PRO Trial

NCT07557017Emotional Disorder

National Institute of Mental Health, Czech Republic

Not applicable

Prague

2025-10-08

Recruiting

Anderson-Fabry Disease Fitness Improvement Training

NCT07495410Fabry Disease

General University Hospital, Prague

Not applicable

Prague

2025-10-06

Recruiting

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

NCT07196722Crohn Disease

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 2/3

1,092

Brno, Kladno, Olomouc, Pardubice, Prague, Praha 1- Mala Strana, Přerov

2025-10-03

Recruiting

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

NCT07207811Transthyretin Amyloid Cardiomyopathy (ATTR CM)

DrugNNC6019-0001

Novo Nordisk A/S

Phase 3

1,280

Broumov, Brno, Olomouc, Ostrava-Poruba, Prague, Uherské Hradiště

2025-10-02

By invitation

A Long-Term Study of Navenibart in Participants With Hereditary Angioedema

NCT07204938Hereditary Angioedema (HAE)

DrugNavenibart

Astria Therapeutics, Inc.

Phase 3

145

Prague

2025-10-01

Recruiting

Natural History of Type 1 Interferonopathies: Insights From a European Cohort

NCT07040774Genetic Disease, Immune Dysfunction, Neurological Diseases or Conditions, Autoimmune Diseases

Imagine Institute

Observational

500

Prague

2025-10-01

Recruiting

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

NCT07184931Crohn's Disease

DrugDuvakitug

Sanofi

Phase 3

980

Brno, Hradec Králové, Prague

2025-10-01

Active, closed

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

NCT07196748Colitis, Ulcerative

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

896

Brno, České Budějovice, Kladno, Olomouc, Pardubice, Prague, Praha 1- Mala Strana, Přerov

2025-10-01

Recruiting

Clinical Course Of Disease In Participants With FA-CM

NCT06865482Friedreich Ataxia, Cardiomyopathy

Lexeo Therapeutics

Observational

Prague

2025-09-30

Recruiting

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

NCT07106762Urothelial Cancer

DrugsIza-bren·Gemcitabine·Cisplatin·Carboplatin

Bristol-Myers Squibb

Phase 2/3

470

Brno, Hradec Králové, Prague

2025-09-30

Recruiting

A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight

NCT07202884Urinary Incontinence,Stress

DrugOrforglipron

Eli Lilly and Company

Phase 3

1,000

Benešov, Brno, Karlovy Vary, Náchod, Olomouc, Ostrava, Pilsen, Prague

2025-09-30

Recruiting

Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

NCT07204275Primary Membranous Nephropathy

DrugsPovetacicept·Tacrolimus

Vertex Pharmaceuticals Incorporated

Phase 2/3

176

Prague

2025-09-30

Recruiting

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

NCT07144280Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Carcinoma

DrugsPF-08046054·Docetaxel

Pfizer

Phase 3

680

Ostrava, Brno, Nový Jičín, Olomouc, Prague

2025-09-29

Recruiting

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

NCT07028853Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

1,000

Brno, Hradec Králové, Olomouc, Prague

2025-09-28

Recruiting

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

NCT07007312Acute Myeloid Leukemia (AML)

DrugsZiftomenib·Ara-C·Daunorubicin·Venclexta

Kura Oncology, Inc.

Phase 3

1,300

Ostrava-Poruba, Prague

2025-09-26

Recruiting

Early Detection of Developmental Abnormalities of Preterm Infants at 5 Years of Age

NCT073915275 Year Old Children Born Prematurely

Institute of Health Information and Statistics of the Czech Republic

Not applicable

210

České Budějovice, Havlíčkův Brod, Liberec, Prague

2025-09-23

Recruiting

Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

NCT07116967Plaque Psoriasis

DrugsUstekinumab·Deucravacitinib

Bristol-Myers Squibb

Phase 3

3,040

Nový Jicín, Prague, Brno, Náchod, Olomouc, Ostrava, Ústí nad Labem

2025-09-22

Recruiting

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

NCT07190222Chronic Obstructive Pulmonary Disease

DrugLunsekimig

Sanofi

Phase 3

942

Brandýs nad Labem-Stará Boleslav, Havlíčkův Brod, Hradec Králové, Jindřichův Hradec, Kralupy nad Vltavou, Prague

2025-09-17

Active, closed

Development of Human Motor Skills and the Promotion of Motivation for Physical Activity

NCT07485270Physical Inactivity, Obesity & Overweight, Motor Development, Cognitive Development

Charles University, Czech Republic

Not applicable

325

Brno, Lomnice, Mohelnice, Pilsen, Prague, Rudná, Velké Popovice

2025-09-11

Recruiting

A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.

NCT07029828Severe Alopecia Areata

DrugsRitlecitinib higher·Ritlecitinib lower

Pfizer

Phase 3

140

Brno, Pilsen, Prague, Praha 8 - Libeň

2025-09-10

Recruiting

Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

NCT06784466Atrial Fibrillation (AF), Persistant Atrial Fibrillation, Paroxysmal AF

Arga Medtech SA

Not applicable

360

Brno, Prague

2025-09-10

Recruiting

Study to Assess Change in Quality of Life of Risankizumab Treatment in Adult Participants With Moderate-to-Severe Plaque Psoriasis

NCT07039110Plaque Psoriasis

AbbVie

Observational

700

Brno, Prague, Pilsen, České Budějovice

2025-09-09

Recruiting

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

NCT07011719Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear Cell Renal Cell Carcinoma

DrugsCasdatifan·Cabozantinib

Arcus Biosciences, Inc.

Phase 3

720

Brno, Brno-střed, České Budějovice, Hradec, Prague

2025-09-08

Recruiting

A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases

NCT07115745Refractory Autoimmune Diseases

DrugsTocilizumab·Fludarabine·Cyclophosphamide

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 1

125

Prague

2025-09-04

Recruiting

A Real World Study to Globally Assess Disease Burden in Adolescent and Adult Participants With Alopecia Areata, Vitiligo, or Hidradenitis Suppurativa

NCT07136467Non-Segmental Vitiligo (NSV), Alopecia Areata, Hidradenitis Suppurativa

AbbVie

Observational

2,795

Prague, Pilsen

2025-09-02

By invitation

An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)

NCT07161700Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress

DrugGlyphAllo

Seaport Therapeutics

Phase 2

360

Brno, Pilsen, Prague

2025-09-02

Recruiting

STOP-HAE: A Phase 3 Study of ADX-324 in HAE

NCT06960213Hereditary Angioedema, HAE, Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2

ADARx Pharmaceuticals, Inc.

Phase 3

Hradec Králové, Prague

2025-08-28

Recruiting

A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)

NCT07200908Chronic Hepatitis D Infection

DrugBulevirtide

Mirum Pharmaceuticals, Inc.

Phase 3

172

Brno, Hradec Králové, Liberec, Prague

2025-08-27

Recruiting

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

NCT07043400Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsLeucovorin·Adrucil·Tislelizumab·Capecitabine

BeOne Medicines

Phase 3

351

Brno, Hradec Králové, Olomouc, Prague

2025-08-27

Recruiting

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

NCT06982521PIK3CA Mutation, HER2- Negative Breast Cancer, Hormone Receptor Positive Tumor, Breast Cancer

DrugsCapivasertib·Fulvestrant

Relay Therapeutics, Inc.

Phase 3

540

Brno, Hořovice, Hradec Králové, Nový Jičín, Olomouc, Prague

2025-08-26

Active, closed

A Study Evaluating TRIV-509 in Atopic Dermatitis

NCT07167758Atopic Dermatitis

Triveni Bio

Phase 2

Ostrava, Pardubice, Prague

2025-08-26

Recruiting

Controlled Remote Monitoring and Optimization of Oxygen Therapy in Preterm Infants

NCT07161908BPD - Bronchopulmonary Dysplasia, Pulmonary Hypertension

Institute of Health Information and Statistics of the Czech Republic

Not applicable

České Budějovice, Olomouc, Prague

2025-08-25

Recruiting

A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)

NCT07058077Heterozygous Familial Hypercholesterolemia (HeFH)

DrugsEnlicitide·Enlicitide Decanoate

Merck Sharp & Dohme LLC

Phase 2/3

153

Brno, Prague

2025-08-21

Active, closed

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine

NCT07018700Episodic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

997

Brno, Hradec Králové, Prague

2025-08-21

Active, closed

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

NCT07018713Chronic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

808

Brno, Hradec Králové, Prague

2025-08-21

Active, closed

A Study of SPY072 in Rheumatic Disease

NCT07148414Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Rheumatic Diseases

DrugSPY072

Spyre Therapeutics, Inc.

Phase 2

285

Hlučín, Moravská Ostrava, Pardubice, Prague, Uherské Hradiště

2025-08-21

Recruiting

Protocol-driven Nutrition in Preterm Infants

NCT07364500Preterm Infants

Institute of Health Information and Statistics of the Czech Republic

Not applicable

400

Brno, České Budějovice, Olomouc, Prague, Zlín

2025-08-21

Recruiting

A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia

NCT07086976Autoimmune Haemolytic Anaemia

DrugRilzabrutinib

Sanofi

Phase 3

Brno, Prague

2025-08-18

Recruiting

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

NCT06887192Psychosis Associated With Alzheimer's Disease

DrugML-007C-MA

MapLight Therapeutics

Phase 2

300

Choceň, Prague

2025-08-15

Recruiting

A Study Investigating Intravenous Human Normal Immunoglobulin 10% in Adults With Chronic Immune Thrombocytopenia (ITP)

NCT07059000Chronic Primary Immune Thrombocytopenia (ITP)

DrugKedrion IVIG

Kedrion S.p.A.

Phase 3

Prague, Brno

2025-08-13

Recruiting

Focused Orticumab Research for Treating Inflammation in Coronary Arteries

NCT06927739Acute Coronary Syndromes, Coronary Arterial Disease (CAD), Inflammation, Heart Disease

Abcentra

Phase 2

240

Ostrava, Pilsen, Prague, Brno

2025-08-11

By invitation

Transfemoral TAVI With or Without Coronary Angiogram in Patients With Severe Aortic Stenosis (PURE TAVI)

NCT06898086Severe Aortic Stenosis

Rede Optimus Hospitalar SA

Not applicable

620

Prague

2025-08-08

Active, closed

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

NCT07094516Alzheimer's Disease

DrugVHB937

Novartis Pharmaceuticals

Phase 2

Brno, Prague

2025-08-07

Recruiting

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

NCT07029581Lewy Body Dementia Psychosis

DrugACP-204

ACADIA Pharmaceuticals Inc.

Phase 2

180

Brno, Choceň, Prague, Rychnov nad Kněžnou

2025-08-06

Recruiting

A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes

NCT07088068Type 1 Diabetes Mellitus

DrugsTzield·Teplizumab

Sanofi

Phase 3

723

Prague

2025-08-06

Recruiting

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

NCT07062965Breast Cancer

DrugsPrifetrastat·Exemestane·Everolimus·Fulvestrant

Pfizer

Phase 3

400

Prague, Nový Jičín

2025-08-05

Recruiting

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

NCT06607458Refractory Metastatic Colorectal Cancer

DrugsMelphalan·Trifluridine/Tipiracil·Bevacizumab

Delcath Systems Inc.

Phase 2

Prague

2025-08-05

Recruiting

HOPE Against Cancer Recurrence in HCC

NCT06717919Liver Transplantation, HCC, Oncological Outcomes

Philipp Dutkowski

Phase 4

220

Prague

2025-08-01

Recruiting

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

NCT07044336Endometrial Cancer, Malignant Solid Tumour

DrugsAdriamycin·Taxol·Doxorubicin·Paclitaxel

AstraZeneca

Phase 3

800

Brno, Hradec Králové, Nový Jičín, Ostrava, Prague, V Uvalu 84

2025-08-01

Not yet open

Expiratory Muscle Training and Trunk Flexion in Parkinson's Disease

NCT06963918Parkinson Disease

General University Hospital, Prague

Not applicable

Prague

2025-08

Active, closed

A Study to Learn About Medicine Called Ritlecitinib in Children Aged Between 6 to 12 Years With Severe Alopecia Areata

NCT07029711Severe Alopecia Areata

DrugsRitlecitinib higher·Ritlecitinib lower

Pfizer

Phase 3

208

Brno, Pilsen, Prague, Praha 8 - Libeň

2025-07-31

Recruiting

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

NCT06757634Breast Cancer

DrugsGedatolisib·Ribociclib·Palbociclib·Letrozole

Celcuity Inc

Phase 3

1,180

Brno, Hořovice, Hradec Králové, Olomouc, Prague

2025-07-24

Recruiting

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

NCT06758401Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)

DrugsSigvotatug vedotin·Pembrolizumab

Pfizer

Phase 3

714

Prague, Liberec1, Nový Jičín, Olomouc

2025-07-23

Recruiting

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

NCT07064473Diabetes Mellitus, Type 2, Hypertension, Cardiovascular Diseases

DrugsVicadrostat·Dapagliflozin

Boehringer Ingelheim

Phase 3

11,800

Brandýs nad Labem, Brno, Havířov, Prague, Uherské Hradiště, Znojmo

2025-07-22

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

NCT07011745Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

426

Olomouc, Prague, Brno, Choceň, Pilsen, Rychnov nad Kněžnou

2025-07-16

Recruiting

Append Prague Study

NCT07816029Non Valvular Atrial Fibrillation

Append Medical Ltd.

Not applicable

Prague

2025-07-16

Recruiting

A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy

NCT06963827Kidney Disease

DrugMezagitamab

Takeda

Phase 3

347

Nový Jičín, Olomouc, Prague

2025-07-15

Active, closed

A Study Evaluating BFB759 in Moderate to Severe Atopic Dermatitis

NCT07105488Atopic Dermatitis (AD)

DrugBFB759

Bluefin Biomedicine, Inc.

Phase 2

225

Ostrava, Pardubice, Prague

2025-07-15

Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

NCT06976216Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

586

Brno, Olomouc, Pilsen, Prague, Rychnov nad Kněžnou

2025-07-14

Recruiting

A Phase 1b/2a Trial to Evaluate Invobenitug Also Known as Procizumab (PCZ; AK1967) in Critical Cardiovascular Care.

NCT06832722Shock, Cardiogenic

4TEEN4 Pharmaceuticals GmbH

Phase 1/2

Pilsen, Prague

2025-07-13

Active, closed

Support C Post-Market Registry

NCT06678490Coronary Arteriosclerosis

OrbusNeich

Observational

282

Liberec, Prague

2025-07-09

Active, closed

A Study to Assess the Efficacy and Safety of Weekly Doses of GLM101 in Participants With PMM2-CDG

NCT06892288Phosphomannomutase 2 Deficiency, PMM2-CDG

Glycomine, Inc.

Phase 2/3

Prague

2025-07-09

Recruiting

ELEVATE-HFpEF Clinical Study

NCT06678841Heart Failure With Preserved Ejection Fraction (HFpEF)

Medtronic Cardiac Rhythm and Heart Failure

Not applicable

700

Prague

2025-07-09

Active, closed

An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

NCT06991556Metastatic Hormone-sensitive Prostate Cancer

DrugsLuxdegalutamide·Abiraterone·Enzalutamide

Novartis Pharmaceuticals

Phase 2

168

Brno, Olomouc, Prague

2025-07-07

Active, closed

A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)

NCT07047118Prostatic Cancer, Castration-Resistant

DrugsLuxdegalutamide·Lu-PSMA

Novartis Pharmaceuticals

Phase 2

138

Prague

2025-07-03

Recruiting

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

NCT07052903Transthyretin Amyloidosis With Cardiomyopathy

DrugNucresiran

Alnylam Pharmaceuticals

Phase 3

1,750

Brno, Ostrava, Prague

2025-07-02

Active, closed

A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD

NCT06981078Chronic Obstructive Pulmonary Disease

DrugVerekitug

Upstream Bio Inc.

Phase 2

666

Broumov, Poruba, Prague, Rokycany, Miroslav, Brandýs nad Labem, Kralupy nad Vltavou, Teplice

2025-07-02

Not yet open

Yoga-based, Movement Therapy Device as Noninvasive Glymphatic Clearance Augmentation in Alzheimer's Disease.

NCT06989242Alzheimer Disease, Mild Cognitive Impairment (MCI)

CIATRIX, INC.

Not applicable

Brno, Prague

2025-07-01

Recruiting

Psilocybin Therapy for Psychological Distress in Palliative Patients

NCT06782724COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis), Major Depressive Disorder (MDD)

University Medical Center Groningen

Phase 2

108

Prague

2025-07-01

Recruiting

A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy

NCT06979375Heart Failure

DrugCDR132L

Novo Nordisk A/S

Phase 2

200

Brno, České Budějovice, Ostrava-Poruba, Prague

2025-06-30

Recruiting

A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults

NCT06937931Cervical Dystonia

DrugCorabotase

Ipsen

Phase 2

132

Brno, Choceň, Olomouc, Prague

2025-06-30

By invitation

A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Moderate to Severe Hidradenitis Suppurativa

NCT07007637Hidradenitis Suppurativa

DrugSonelokimab

MoonLake Immunotherapeutics AG

Phase 3

835

Ostrava, Prague

2025-06-27

Recruiting

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

NCT06937086Ulcerative Colitis, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

350

Brno, Hradec Králové, Ostrava, Prague, Ústí nad Labem

2025-06-26

Recruiting

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099Crohn's Disease, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

290

Brno, Hradec Králové, Ostrava, Prague, Ústí nad Labem

2025-06-26

Recruiting

A Clinical Trial to Test the Safety, Tolerability, and How the Body Processes CPV-104 in Healthy People and Patients With C3-Glomerulopathy

NCT07483827C3 Glomerulopathy (C3G), Healthy Adult Participants

eleva GmbH

Phase 1

Prague

2025-06-26

Recruiting

INNODIA Family & Friends Early-Stage T1D Detection Protocol

NCT07118098Type 1 Diabetes (T1D), Pre Diabetes

INNODIA iVZW

Observational

30,000

Prague

2025-06-25

Recruiting

Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

NCT06961214Pulmonary Disease, Chronic Obstructive

DrugDepemokimab

GlaxoSmithKline

Phase 3

961

Jindřichův Hradec, Kralupy nad Vltavou, Nymburk, Prague, Varnsdorf

2025-06-23

Recruiting

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

NCT06846281Relapsing Multiple Sclerosis

DrugsRemibrutinib·Ocrelizumab

Novartis Pharmaceuticals

Phase 3

400

Brno, Hradec Králové, Jihlava, Pardubice, Prague

2025-06-23

Recruiting

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

NCT07018323Graves' Disease

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

210

Náchod, Prague

2025-06-19

Recruiting

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

NCT07065240Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress

DrugGlyphAllo

Seaport Therapeutics

Phase 2

360

Brno, Pilsen, Prague

2025-06-19

Recruiting

Efficacy and Safety of the APGO Algorithm for Automated Insulin Delivery

NCT07320495Diabetes Mellitus Type 1

Charles University, Czech Republic

Not applicable

200

Prague

2025-06-19

Recruiting

The Combined First Trimester Screening

NCT07015203Preeclampsia (PE), Fetal Growth Restriction, Congenital Abnormalities, Preterm Labor

Institute of Health Information and Statistics of the Czech Republic

Observational

2,000

Most, Olomouc, Prague

2025-06-15

Recruiting

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

NCT06943872Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsSonrotoclax·Venclexta·Obinutuzumab·Venetoclax

BeOne Medicines

Phase 3

630

Brno, Hradec Králové, Prague

2025-06-11

Recruiting

PMCF Investigation of Medical Device ChitoCare® Medical

NCT06850389Dermatitis, Acne, Conditions After Dematosurgical Procedures, Scars

Primex ehf

Observational

214

Prague

2025-06-11

Active, closed

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFH

NCT07000136Heterozygous Familial Hypercholesterolaemia

DrugAZD0780

AstraZeneca

Phase 3

473

Hradec Králové, Prague, Uherské Hradiště

2025-06-10

Recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

NCT06340568Endometrial Cancer

DrugsDoxorubicin·Docetaxel·Paclitaxel

BioNTech SE

Phase 3

480

Brno, Olomouc, Ostrava, Prague

2025-06-10

Recruiting

The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

NCT06872892Bronchiectasis

DrugVerducatib

Boehringer Ingelheim

Phase 3

1,755

Jindřichův Hradec, Prague

2025-06-09

Recruiting

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

NCT06782490Multiple Sclerosis Spasticity

DrugIrafamdastat

Celgene

Phase 2

200

Brno, Hradec Králové, Prague, Pardubice, Zlín, Teplice

2025-06-05

Recruiting

A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema

NCT06962839Macular Edema

Boehringer Ingelheim

Phase 2

300

Hradec Králové, Ostrava-Poruba, Pardubice, Prague

2025-06-05

Recruiting

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

NCT06852222Leukemia, Myeloid, Acute

DrugsBleximenib·Azacitidine·Venetoclax

Janssen Research & Development, LLC

Phase 3

600

Brno, Hradec Králové, Ostrava - Poruba, Pilsen, Prague

2025-06-04

Active, closed

A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy

NCT06821542Chronic Graft-versus-host-disease

DrugAxatilimab

Incyte Corporation

Phase 3

Hradec Králové, Ostrava-poruba, Prague

2025-06-04

Recruiting

A Prospective Multicenter Diagnostic Biomarker Study to Discriminate Borderline From Stage I Invasive Ovarian Cancer

NCT06709872Stage I Ovarian Cancer, Borderline Ovarian Tumors

KU Leuven

Observational

400

Prague

2025-06-03

Recruiting

Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma

NCT07130851Vestibular Schwannoma, Unilateral Vestibular Deficit, Healthy

Marketa Bonaventurova

Not applicable

Prague

2025-06-01

Recruiting

Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening

NCT07033091Oropharynx Cancer

The Institute of Molecular and Translational Medicine, Czech Republic

Not applicable

20,000

Brno, Jihlava, Olomouc, Prague

2025-06-01

Recruiting

Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)

NCT07424963Cirrhosis, Portal Hypertension, EUS, Non-Cirrhotic Portal Hypertension

Military University Hospital, Prague

Not applicable

Prague

2025-05-30

Active, closed

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event

NCT07000123Cardiovascular Disease

DrugAZD0780

AstraZeneca

Phase 3

3,103

Benešov, Brandýs nad Labem, Chlumec nad Cidlinou, České Budějovice, Hodonín, Jílové u Prahy, Klatovy, Prague

2025-05-28

Recruiting

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

NCT07012395Ulcerative Colitis, Inflammatory Bowel Diseases, Colitis, Colitis, Ulcerative

DrugsSPY001·SPY002·SPY003

Spyre Therapeutics, Inc.

Phase 2

645

Brno, Klatovy, Ostrava, Pardubice, Prague

2025-05-27

Recruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

NCT06941272Malignant Neoplasm

DrugPatritumab deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

Brno, Prague

2025-05-26

Recruiting

A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

NCT06901531Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

DrugsZolbetuximab·Adrucil·Capecitabine·Oxaliplatin

Astellas Pharma Global Development, Inc.

Phase 3

500

Brno, Olomouc, Prague

2025-05-22

Active, closed

Study of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age

NCT06975878Pneumococcal Immunization, Healthy Volunteers

DrugsVaxneuvance·PCV21 vaccine·Vaxelis vaccine·Varivax

Sanofi

Phase 3

1,092

Jindřichův Hradec, Krnov, Pilsen, Prague

2025-05-22

Recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

NCT06952504Endometrial Cancer

DrugsSacituzumab tirumotecan·Keytruda·Docetaxel·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

1,123

Ostrava, Nový Jičín, Prague

2025-05-22

Active, closed

A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia

NCT06843590Idiopathic Hypersomnia

DrugALKS 2680

Alkermes, Inc.

Phase 2

126

Prague

2025-05-22

Active, closed

Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa

NCT06940830Hemophilia A

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 4

252

Brno, Ostrava, Prague

2025-05-21

Recruiting

Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study Treatment Withdrawal in Participants With Lupus Nephritis (SIRIUS-LN Extension)

NCT06711887Lupus Nephritis

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

348

Olomouc, Prague

2025-05-19

Active, closed

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

NCT06972472Obesity, Overweight, Type 2 Diabetes

DrugOrforglipron

Eli Lilly and Company

Phase 3

600

České Budějovice, Český Krumlov, Ostrava, Prague, Uherské Hradiště

2025-05-19

Recruiting

A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

NCT06522737Lymphoma

DrugsDuvelisib·Bendamustine·Gemcitabine

SecuraBio

Phase 3

124

Prague

2025-05-19

Recruiting

Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

NCT06830798Delayed Graft Function, DGF, Kidney Transplant

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Phase 3

450

Hradec Kralova, Ostrava, Prague

2025-05-19

Recruiting

Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis

NCT06947993Atopic Dermatitis

Novartis Pharmaceuticals

Phase 2

224

Plzen Bory, Prague

2025-05-16

Active, closed

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

NCT06972459Obesity, Overweight

DrugOrforglipron

Eli Lilly and Company

Phase 3

800

České Budějovice, Český Krumlov, Ostrava, Prague, Uherské Hradiště

2025-05-15

Active, closed

A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes

NCT06993792Obesity, Overweight, Type 2 Diabetes

DrugOrforglipron

Eli Lilly and Company

Phase 3

1,400

České Budějovice, Český Krumlov, Ostrava, Prague, Uherské Hradiště

2025-05-15

Active, closed

RADIQAL Study (Radiation Dose and Image Quality Trial)

NCT06944509Coronary Artery Disease

Philips Clinical & Medical Affairs Global

Not applicable

824

Prague

2025-05-14

Recruiting

A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

NCT07003425Atopic Dermatitis

DrugAPG777

Apogee Therapeutics, Inc.

Phase 2

350

Prague

2025-05-14

Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

NCT06925737Prostate Cancer, Prostatic Neoplasms

DrugsIfinatamab Deruxtecan·Prednisolone·Prednisone·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

1,440

Brno, Ostrava - Poruba, Prague, Olomouc

2025-05-13

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

NCT06925750Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

130

Prague

2025-05-12

Recruiting

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

NCT06819891Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

425

Hradec Králové, Ostrava - Poruba, Prague, Ústí nad Labem

2025-05-12

Active, closed

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

NCT06962280Type 1 Diabetes, Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

465

Chrudim III, Hranice, Krnov, Olomouc, Prague

2025-05-12

Recruiting

A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)

NCT06935357Immunoglobulin A Nephropathy (IgAN)

DrugFelzartamab

Biogen

Phase 3

454

Prague

2025-05-08

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT06499285Myelodysplastic Syndromes

DrugElritercept

Takeda

Phase 3

225

Brno, Hradec Králové, Ostrava, Prague

2025-05-06

Recruiting

Effect of Visual Feedback From the SpiroGym Mobile Application

NCT06942533Parkinson Disease, Breathing Exercises, Telemedicine

General University Hospital, Prague

Not applicable

Prague

2025-05-01

Recruiting

PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis

NCT06855329Progressive Pulmonary Fibrosis, Interstitial Lung Disease

University of Massachusetts, Worcester

Observational

500

Prague

2025-05-01

Recruiting

Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation

NCT06868823Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders

University Hospital, Motol

Observational

Prague

2025-05-01

Recruiting

Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients

NCT06921746Overactive Bladder

University Hospital Ostrava

Observational

Ostrava, Prague

2025-05-01

Recruiting

TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden

NCT07107477Preterm Premature Rupture of Membranes (PPROM)

The Central and Eastern European Gynecologic Oncology Group

Phase 3

138

Brno, Prague

2025-05-01

Active, closed

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

NCT06948435Hypertension, Overweight or Obesity

DrugOrforglipron

Eli Lilly and Company

Phase 3

487

Brno, Hodonín, Ledeč nad Sázavou, Ostrava, Pardubice V, Prague

2025-04-30

Active, closed

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2

NCT06952530Hypertension

DrugOrforglipron

Eli Lilly and Company

Phase 3

487

Brno, Hodonín, Ledeč nad Sázavou, Ostrava, Pardubice V, Prague

2025-04-30

Active, closed

A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)

NCT06948422Hypertension

DrugOrforglipron

Eli Lilly and Company

Phase 3

974

Brno, Hodonín, Ledeč nad Sázavou, Ostrava, Pardubice V, Prague

2025-04-30

Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

NCT06820463Metastatic Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Panitumumab·Fluorouracil·Leucovorin

AbbVie

Phase 2

390

Prague, Brno, Hradec Králové

2025-04-24

Recruiting

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT06966401Major Depressive Disorder

DrugOsavampator

Neurocrine Biosciences

Phase 3

850

Pilsen, Prague

2025-04-16

Recruiting

A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

NCT06846671CLL, Chronic Lymphocytic Leukemia

DrugsIdelalisib·Tacabrutideg·Bendamustine·Venetoclax

BeOne Medicines

Phase 3

250

Brno, Hradec Králové, Ostrava, Prague

2025-04-10

Recruiting

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

NCT06824467Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

DrugsSteroid mouthwash (dexamethasone·Mvasi·Acetaminophen·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

770

Brno, Ostrava-Poruba, Prague

2025-04-09

Active, closed

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

NCT06822790Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

710

Hodonín, Hradec Králové, Náchod, Olomouc, Prague, Praha 4-Krc, Slaný, Teplice

2025-04-09

Active, closed

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

NCT07108166COPD, Smoking, Tobacco Use

Philip Morris Products S.A.

Not applicable

290

Kralupy nad Vltavou, Olomouc, Ostrava, Prague, Varnsdorf

2025-04-02

By invitation

Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP

NCT06859099Polyneuropathy, Inflammatory Demyelinating, Chronic

DrugRiliprubart

Sanofi

Phase 3

300

Brno, Prague

2025-04-01

Recruiting

A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata

NCT06873945Alopecia Areata

DrugsLitfulo·Ritlecitinib

Pfizer

Phase 3

674

Pilsen, Prague, Pardubice

2025-04-01

By invitation

Additive Effects of Interoceptive Training to Physiotherapy in Functional Movement Disorders (interoPTfmd)

NCT06792760Functional Neurological Disorder, Functional Movement Disorder

Charles University, Czech Republic

Not applicable

Prague

2025-04-01

Recruiting

Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE

NCT07874139Chronic Lung Diseases

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Observational

683

Prague

2025-03-31

Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

NCT06890598Carcinoma, Non-Small-Cell Lung

DrugsOlomorasib·Durvalumab·Pembrolizumab

Eli Lilly and Company

Phase 3

700

Ostrava, Prague

2025-03-27

Active, closed

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa

NCT06840392Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

565

Karlovy Vary, Plzen Bolevec, Prague

2025-03-20

Active, closed

A Study of Navenibart in Participants With Hereditary Angioedema

NCT06842823Hereditary Angioedema (HAE)

DrugNavenibart

Astria Therapeutics, Inc.

Phase 3

157

Hradec Králové, Prague

2025-03-20

Recruiting

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

NCT06819007Ovarian Cancer

DrugsTrastuzumab deruxtecan·Bevacizumab

Daiichi Sankyo

Phase 3

582

Ostrava-Poruba, Prague

2025-03-19

Recruiting

Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

NCT06641362Bradycardia, Heart Failure, Ventricular Dysfunction

VDI Technologies

Observational

360

Brno, Prague

2025-03-18

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

NCT06883305Chronic Obstructive Pulmonary Disease (COPD)

DrugTezepelumab

AstraZeneca

Phase 3

990

Brandýs nad Labem, Brno, Jindřichův Hradec, Lovosice, Pilsen, Prague, Teplice, Varnsdorf

2025-03-18

Active, closed

Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

NCT06858878Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight

DrugMaridebart cafraglutide

Amgen

Phase 3

1,105

Brno, Ostrava, Pardubice, Prague, Pribram VIII

2025-03-17

Recruiting

EXTERNAL NEGATIVE PRESSURE DURING LISA

NCT07271368Neonatology

Charles University, Czech Republic

Not applicable

Prague

2025-03-17

Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT06841354Triple Negative Breast Neoplasms

DrugsAbraxane·Paraplatin·Sacituzumab tirumotecan·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,000

Ostrava - Poruba, Prague, Brno, Olomouc

2025-03-16

Recruiting

Impact of Delivery Method Elite Athletes.

NCT06803979Delivery, Performance, Caesarean Section, Pregnancy

Faculty Hospital Kralovske Vinohrady

Observational

500

Prague

2025-03-16

Not yet open

Neonatal Oximeter Bias Study

NCT06817850Neonatal Respiratory Distress, Oxygenation

Czech Technical University in Prague

Observational

Prague

2025-03-15

Active, closed

EucaLimus Post-Market Registry

NCT06621524Coronary Arterioscleroses

OrbusNeich

Observational

251

Liberec, Prague

2025-03-14

Recruiting

A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis

NCT06869551Juvenile Psoriatic Arthritis

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

Olomouc, Prague

2025-03-13

Active, closed

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

NCT06764485Metastatic Castration-resistant Prostate Cancer

DrugsAbiraterone·Enzalutamide·Docetaxel

Celgene

Phase 3

960

Brno, Hradec Králové, Olomouc, Prague

2025-03-13

Active, closed

Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

NCT06858839Obesity

DrugMaridebart cafraglutide

Amgen

Phase 3

3,853

Brandýs nad Labem, Brno, Havířov, Olomouc, Ostrava, Prague

2025-03-12

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

NCT06615479Relapsed or Refractory Multiple Myeloma (RRMM)

DrugsArlo-cel·Carfilzomib·Pomalidomide·Daratumumab

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 3

440

Brno, Hradec Králové, Ostrava, Prague

2025-03-12

Recruiting

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

NCT06830044Major Depressive Disorder (MDD)

Vanda Pharmaceuticals

Phase 3

500

Brno, Pilsen, Poruba, Prague

2025-03-03

Recruiting

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

NCT06671483Psoriatic Arthritis

DrugZasocitinib

Takeda

Phase 3

1,088

Brno, Hlučín, Prague, Uherské Hradiště, Ostrava, Zlín, Pardubice

2025-03-03

Recruiting

Strength-Endurance Circuit Training in Parkinson's Disease

NCT06893055Parkinson Disease, Idiopathic

General University Hospital, Prague

Not applicable

Prague

2025-03-03

By invitation

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

NCT06823115Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors

Indiana University

Observational

8,000

Prague

2025-03-01

Not yet open

Detection of Muscle Quality in Children - Protocol for a Validation Study

NCT06792279Ultrasonography

Charles University, Czech Republic

Observational

120

Prague

2025-03-01

By invitation

AR-Based Motor Rehabilitation for Children With CP

NCT07664878Cerebral Palsy (CP), Augmented Reality Exercise Program

College of Physical Education and Sport PALESTRA

Not applicable

Prague

2025-03-01

Recruiting

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

NCT06855498Hidradenitis Suppurativa (HS)

DrugPovorcitinib

Incyte Corporation

Phase 3

600

Ostrava-poruba, Prague, Praha 13-stodulky

2025-02-28

Recruiting

IMPACT-AML: A Randomized Pragmatic Clinical Trial for Relapsed or Refractory Acute Myeloid Leukemia.

NCT06713837Acute Myeloid Leukemia, Relapse/Recurrence

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Phase 3

339

Brno, Hradec Králové, Olomouc, Ostrava, Pilsen, Prague

2025-02-27

Recruiting

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

NCT06731478Gastric Cancer, Gastroesophageal Junction Cancer

DrugsTrastuzumab deruxtecan·Trastuzumab·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

726

Brno, Hradec Králové, Olomouc, Prague

2025-02-27

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

NCT06646276Extensive-Stage Small Cell Lung Cancer

DrugsEtoposide·Atezolizumab·Nivolumab·Carboplatin

Bristol-Myers Squibb

Phase 3

530

Brno, Ostrava, Prague, Olomouc

2025-02-25

Recruiting

Chronic Kidney Disease Screening

NCT07153432Chronic Kidney Diseases

Institute for Clinical and Experimental Medicine

Observational

3,000

Prague

2025-02-24

Active, closed

A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis

NCT06878404Arthritis, Psoriatic

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

552

Brno, Brno-Židenice, Břeclav, Hlučín, Karvina Frystat, Ostrava, Prague, Uherské Hradiště

2025-02-21

Recruiting

A Study to Assess How Vaborem® is Taking up in the Body and Tolerated in Paediatric Patients With Gram Negative Infections, Including But Not Restricted to Complicated Urinary Tract Infections

NCT06828848Gram Negative Infections

DrugMeropenem

Menarini Group

Phase 2

Ostrava, Prague

2025-02-18

Recruiting

Effect of Trunk Flexion on Airway Defense in Parkinson's Disease

NCT06955377Parkinson Disease

General University Hospital, Prague

Observational

100

Prague

2025-02-18

Recruiting

Feasibility Study of the FARAFLEX Mapping and PFA System

NCT06510556Atrial Fibrillation, Persistent Atrial Fibrillation, Paroxysmal AF

Boston Scientific Corporation

Not applicable

250

Prague

2025-02-17

Active, closed

Study of Oral Atogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

NCT06806293Menstrual Migraine (MM)

DrugAtogepant

AbbVie

Phase 3

468

Brno, Pilsen, Prague, Hradec Králové, Olomouc

2025-02-10

Not yet open

The Influence of Secretin Stimulated Pancreatic Secretion on ctDNA Expression in Patients With Pancreatic Ductal Adenocarcinoma: The Role of Biomarkers in Determining the Prognosis of Pancreatic Ductal Adenocarcinoma

NCT06807112Pancreatic Adenocarcinoma, Pancreatic Cancer

Charles University, Czech Republic

Observational

Prague

2025-02-09

Active, closed

Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer

NCT06619236Platinum-resistant Ovarian Cancer

DrugsRina-S·Pegylated liposomal doxorubicin·Topotecan·Gemcitabine

Genmab

Phase 3

584

Prague, Brno, Hradec Králové, Nový Jičín

2025-02-07

Recruiting

Robotic Rehabilitation of the Upper Limb in Subacute Stroke

NCT06839482Stroke

IRCCS San Raffaele Roma

Not applicable

130

Kladruby, Lázně Bělohrad, Olomouc, Prague

2025-02-06

Active, closed

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

NCT06834360Chronic Rhinosinusitis With Nasal Polyps

DrugsItepekimab·Mometasone furoate

Sanofi

Phase 3

216

Hradec Králové, Pardubice, Pilsen, Prague

2025-02-06

Active, closed

A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)

NCT06680817Neovascular Age-related Macular Degeneration, Diabetic Macular Edema

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Observational

875

Liberec, Mladá Boleslav, Olomouc, Ostrava, Prague

2025-02-05

Recruiting

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

NCT06651970Chronic Lymphocytic Leukaemia, Moderate to Severe Cardiac Impairment

DrugAcalabrutinib

AstraZeneca

Phase 4

Brno, Hradec Králové, Prague

2025-02-04

Active, closed

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

NCT06556563Glioblastoma

DrugsTemozolomide·Keytruda·Pembrolizumab

NovoCure GmbH

Phase 3

741

Prague

2025-02-03

Recruiting

Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study

NCT07057297Carotid Arteriosclerosis, Carotid Stenosis, Brain Stroke

Charles University, Czech Republic

Observational

300

Prague

2025-02-01

Recruiting

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

NCT06564038Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma, Large B-cell Lymphoma

DrugsSurovatamig·Acalabrutinib·Vincristine·Doxorubicin

AstraZeneca

Phase 1/2

408

Ostrava - Poruba, Prague, Praha 2 - Nové Město

2025-01-30

Active, closed

A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)

NCT06809595Generalized Anxiety Disorder

DrugDT120

Definium Therapeutics US, Inc.

Phase 3

245

Pilsen, Prague

2025-01-29

Recruiting

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

NCT06788990Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

DrugsFicerafusp alfa·Keytruda·Pembrolizumab

Bicara Therapeutics

Phase 2/3

650

Hradec Králové, Prague

2025-01-28

Recruiting

Efficacy and Safety of KBP-336 in Obese Individuals with Osteoarthritis

NCT06833749Osteoarthritis in the Knee, Obesity

KeyBioscience AG

Phase 2

600

Brno, Hlučín, Hradiště, Pardubice, Prague

2025-01-28

Recruiting

A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia

NCT06767683Narcolepsy Type 1, Narcolepsy Type 2, Idiopathic Hypersomnia

DrugALKS 2680

Alkermes, Inc.

Phase 2/3

786

Prague

2025-01-27

Recruiting

Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).

NCT06641414Higher-risk Myelodysplastic Syndrome

DrugsLisaftoclax·Azacitidine

Ascentage Pharma Group Inc.

Phase 3

490

Brno, Hradec Králové, Ostrava, Prague

2025-01-22

Recruiting

Rapid Prehospital ACcess to ECPR in Prague

NCT06789978Out of Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation

General University Hospital, Prague

Not applicable

Prague

2025-01-20

Recruiting

New Onset of Arrhythmia After Patent Foramen Ovale (PFO) Closure

NCT06983613Cardiovascular Diseases

Na Homolce Hospital

Observational

150

Prague

2025-01-15

Recruiting

A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants

NCT06758492Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Video Laryngoscopy, Surfactant

University College Dublin

Observational

600

Brno, Prague

2025-01-13

Recruiting

A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants

NCT06757543Intubation, Intubation Complications, Infant, Newborn, Infant Respiratory Distress Syndrome

University College Dublin

Not applicable

840

Brno, Prague

2025-01-13

Recruiting

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

NCT06740630Chickenpox

DrugsHepatitis A vaccine·MMR vaccine·PCV (pneumococcal conjugate vaccine) 13·PCV 20

GlaxoSmithKline

Phase 3

1,840

Jindřichův Hradec, Jinočany, Ostrava, Prague

2025-01-10

Active, closed

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

NCT06807424Arthritis, Psoriatic

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

813

Brno, Břeclav, Hlučín, Ostrava, Prague, Uherské Hradiště, Zlín

2025-01-09

Recruiting

Radiologic Features of Rheumatoid Arthritis Interstitial Lung Disease at Chest High Resolution Computed Tomography

NCT07174102Reumatoid Arthritis, Interstitial Lung Disease Due to Systemic Disease (Disorder), Idiopathic Pulmonary Fibrosis (IPF), Connective Tissue Disease (CTD)

Azienda Unita Sanitaria Locale di Piacenza

Observational

500

Prague

2025-01-08

Active, closed

Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis

NCT06846541Plaque Psoriasis, Psoriasis (PsO), Psoriasis, Moderate Psoriasis

Alumis Inc

Phase 3

1,680

Náchod, Ostrava, Prague, Brno, Kutná Hora, Nový Jičín, Olomouc, Pardubice

2025-01-08

Active, closed

Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease

NCT06760637Breast Cancer

DrugsAtirmociclib·Ribociclib·Abemaciclib·Palbociclib

Pfizer

Phase 3

1,035

Brno, Prague, Nový Jičín

2025-01-06

Recruiting

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NCT06588478Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugPirtobrutinib

Loxo Oncology, Inc.

Phase 2

249

Brno, Hradec Králové, Prague

2025-01-03

Recruiting

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

NCT06227910Crohn's Disease

DrugsVedolizumab·Upadacitinib

Takeda

Phase 3

396

České Budějovice, Hradec Králové, Prague

2025-01-02

Recruiting

Left Atrial Posterior Wall and Mitral Isthmus PF Ablation in Non-Paroxysmal AF Patients

NCT06801392Atrial Fibrillation (AF)

Charles University, Czech Republic

Observational

Prague

2025-01-01

Not yet open

Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.

NCT06672601Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy

Charles University, Czech Republic

Observational

150

Prague

2025-01-01

Recruiting

LIDRISE Study: A Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops, Single Dose) in the Treatment of Acquired Blepharoptosis.

NCT06514612Acquired Blepharophimosis

Santen SAS

Phase 3

234

Pardubice, Pilsen, Prague

2024-12-30

Active, closed

A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)

NCT06593522MTAP-deleted NSCLC

DrugAnvumetostat

Amgen

Phase 2

Brno, Olomouc, Prague

2024-12-26

Recruiting

A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease

NCT06500702Focal Segmental Glomerulosclerosis, Glomerulonephritis Minimal Lesion

DrugsBrivekimig·Frexalimab·Rilzabrutinib

Sanofi

Phase 2

Olomouc, Prague

2024-12-19

Active, closed

A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy

NCT06742190Multifocal Motor Neuropathy (MMN), MMN

DrugsEmpasiprubart·Immunoglobulin·IVIG

argenx

Phase 3

154

Brno, Hradec Králové, Prague

2024-12-18

Recruiting

A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

NCT06679101Multiple Myeloma, Newly Diagnosed Multiple Myeloma

DrugsBelantamab mafodotin·Daratumumab·Lenalidomide·Dexamethasone

GlaxoSmithKline

Phase 3

520

Ostrava, Prague

2024-12-16

Active, closed

Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

NCT06608927Metastatic Pancreatic Ductal Adenocarcinoma

DrugsQuemliclustat·Nab-paclitaxel·Gemcitabine

Arcus Biosciences, Inc.

Phase 3

610

Brno, Nový Jičín, Prague

2024-12-13

Recruiting

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

NCT06526195Heart Failure, Heart Diseases, Cardiovascular Diseases, Pulmonary Hypertension

Abbott Medical Devices

Not applicable

850

Prague

2024-12-13

Recruiting

Pulmonary Vein Isolation With the Single Shot Endoscopic Ultra-Compliant PFA Balloon for the Treatment of AF

NCT06828939Atrial Fibrillation (Paroxysmal)

CardioFocus

Not applicable

100

Prague

2024-12-12

Recruiting

A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis

NCT06636656Ulcerative Colitis

Boehringer Ingelheim

Phase 2

Hradec Králové, Prague

2024-12-11

Active, closed

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06588855Moderately to Severely Active Ulcerative Colitis

DrugAfimkibart

Hoffmann-La Roche

Phase 3

350

Hradec Králové, Prague

2024-12-11

Recruiting

Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia

NCT06597019Familial Hypercholesterolemia - Heterozygous

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

Prague

2024-12-09

By invitation

Phase 1b Long-term Extension Trial of RAY121 in Immunological Diseases (RAINBOW-LTE Trial)

NCT06723106Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)

DrugRAY121

Chugai Pharmaceutical

Phase 1

144

Prague

2024-12-09

Recruiting

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

NCT06679140COVID-19 SARS-CoV-2 Infection

DrugIbuzatrelvir

Pfizer

Phase 3

2,330

Brno, Prague, České Budějovice, Protivín, Olomouc

2024-12-08

Recruiting

Closed-loop in Adults With Type 2 Diabetes

NCT06579404Type 2 Diabetes Treated With Insulin

University of Cambridge

Not applicable

224

Prague

2024-12-06

Recruiting

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.

NCT06382948Advanced Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, ESR1 Gene Mutation

DrugsElacestrant·Everolimus

MedSIR

Phase 3

300

Brno, Hořovice, Olomouc, Prague, Zlín

2024-12-05

Active, closed

Nipocalimab in Moderate to Severe Sjogren's Disease

NCT06741969Sjogrens Syndrome

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

655

Brno, Karvina Frystat, Ostrava, Prague, Uherské Hradiště

2024-12-04

By invitation

A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

NCT06679946Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

DrugVutrisiran

Alnylam Pharmaceuticals

Phase 3

700

Prague

2024-12-03

Recruiting

A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

NCT06717698Chronic Kidney Disease

DrugSemaglutide

Novo Nordisk A/S

Phase 2

465

Český Krumlov, Frýdek-Místek, Hodonín, Prague, Smiřice

2024-12-02

Not yet open

High Flow Nasal Cannula for Stabilization of Extremely Premature Infants

NCT06683677Premature Infant, Ventilation Therapy, High Flow Nasal Canula

Charles University, Czech Republic

Not applicable

Prague

2024-12-01

Active, closed

A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56

NCT06683742Wet Age Related Macular Degeneration, wAMD

DrugsEYP-1901·Aflibercept

EyePoint Pharmaceuticals, Inc.

Phase 3

400

Náchod, Prague

2024-11-27

By invitation

The Effect of DNS Therapy on Asymmetry in Children After Surgery of Congenital Heart Disease

NCT06776822Congenital Heart Disease in Children

Charles University, Czech Republic

Not applicable

Prague

2024-11-20

Recruiting

A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis

NCT06443502Pouchitis

DrugVedolizumab

Takeda

Phase 3

Prague

2024-11-19

Active, closed

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

NCT06578247Leukemia

DrugQuizartinib

Daiichi Sankyo

Phase 3

700

Brno, Hradec Králové, Pilsen, Poruba, Prague

2024-11-19

Recruiting

National Childhood Obesity Prevention Programme BE FIT 24

NCT07057453Childhood Obesity

Institute of Health Information and Statistics of the Czech Republic

Not applicable

1,000

Prague

2024-11-19

Active, closed

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

NCT06616194Migraine

DrugRimegepant

Pfizer

Phase 3

636

Brno, Hradec Králové, Ostrava, Prague

2024-11-15

Recruiting

LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis

NCT06632457Metabolic Dysfunction Associated Steatohepatitis

Boehringer Ingelheim

Phase 3

1,590

Liberec, Pilsen, Prague

2024-11-12

Active, closed

A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis

NCT06655155Systemic Sclerosis (SSc)

argenx

Phase 2

Prague

2024-11-11

Active, closed

A Study on Safety and Effectiveness of Long-term Treatment With Vamorolone in Boys With Duchenne Muscular Dystrophy

NCT06713135Duchenne Muscular Dystrophy

DrugVamorolone

Santhera Pharmaceuticals

Phase 4

Brno, Prague

2024-11-10

Active, closed

Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants

NCT06647407Meningococcal Immunization, Healthy Volunteers

DrugsNimenrix·Vaxelis vaccine·Bexsero·Paracetamol

Sanofi Pasteur, a Sanofi Company

Phase 1/2

750

Jindřichův Hradec, Ostrava, Pilsen, Prague

2024-11-05

Active, closed

A Study About the Long-Term Safety of TAK-881 in People With Primary Immunodeficiency Diseases

NCT06076642Primary Immunodeficiency Diseases (PID)

DrugTAK-881

Takeda

Phase 3

Brno, Prague

2024-11-04

Recruiting

Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs

NCT06967740Cervical Cancer, Cervical Intraepithelial Neoplasia (CIN), Risk Factors, Conservative Management

Nikola Janovska

Observational

200

Prague

2024-11-01

Recruiting

Biodegradable Stents in Liver Transplant RecipIents for Treatment of Biliary Anastomotic Strictures

NCT06716541Liver Transplant, Complications, Biliary Anastomotic Stenosis, Endoscopic Retrograde Cholangiopancreatography

Institute for Clinical and Experimental Medicine

Not applicable

Prague

2024-11-01

Recruiting

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

NCT06456593Moderately to Severely Active Crohn Disease

DrugObefazimod

Abivax S.A.

Phase 2

212

Brno, Hradec Králové, Olomouc, Prague, Slaný

2024-10-30

Active, closed

Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis

NCT06655896Scleroderma, Diffuse

DrugsRapcabtagene autoleucel·Rituximab

Novartis Pharmaceuticals

Phase 2

Olomouc, Prague

2024-10-29

Active, closed

A Study of Mosliciguat in PH-ILD

NCT06635850Pulmonary Hypertension, Interstitial Lung Disease, Lung Diseases, Vascular Diseases

DrugMosliciguat

Pulmovant, Inc.

Phase 2

135

Prague

2024-10-29

Recruiting

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

NCT06649110Healthy Volunteers, Pulmonary Arterial Hypertension

Novartis Pharmaceuticals

Phase 1/2

232

Prague

2024-10-24

Active, closed

CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I Trial

NCT06765876Leukemia, Myeloid, Acute(AML), Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic Syndromes (MDS), Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Institute of Hematology and Blood Transfusion, Czech Republic

Early Phase 1

Prague

2024-10-23

Recruiting

A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia

NCT06651567Agitation Associated With Alzheimer's Dementia

DrugITI-1284

Intra-Cellular Therapies, Inc.

Phase 2

320

Brno, Choceň, Kutná Hora, Pilsen, Prague

2024-10-22

Active, closed

Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV.

NCT06321601Vasculitis

DrugAvacopan

Amgen

Phase 3

Prague

2024-10-22

Recruiting

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

NCT06629779Metastatic Castration-Resistant Prostate Cancer

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

900

Ostrava - Poruba, Olomouc, Pardubice, Prague, Liberec

2024-10-22

Active, closed

A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).

NCT06551324Metastatic Castrate Resistant Prostate Cancer (mCRPC)

DrugsMevrometostat·Xtandi·Taxotere·Enzalutamide

Pfizer

Phase 3

609

Olomouc, Pardubice, Prague

2024-10-21

Recruiting

A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia

NCT06544499Primary Immune Thrombocytopenia (ITP)

DrugEfgartigimod

argenx

Phase 3

Ostrava, Prague

2024-10-18

Active, closed

Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis Naive to Biologic Disease-Modifying Antirheumatic Drug

NCT06641076Arthritis, Psoriatic

DrugSonelokimab

MoonLake Immunotherapeutics AG

Phase 3

960

Brno, Břeclav, Ostrava, Prague, Studénka, Zlín

2024-10-15

Recruiting

LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

NCT06632444Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis

Boehringer Ingelheim

Phase 3

1,800

Liberec, Pilsen, Prague

2024-10-14

Recruiting

A Phase II Randomized, Open Label Non-inferiority Study of NiraParib Maintenance After 3 vs. 6 Cycles of Platinum-based Chemotherapy in completeLy debUlked Advanced HRDpositive High-grade Ovarian Cancer patientS in First Line Therapy

NCT05460000Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Clear Cell Carcinoma

North Eastern German Society of Gynaecological Oncology

Phase 2

640

Ostrava, Prague

2024-10-11

Active, closed

A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

NCT06625060Episodic Migraine, Chronic Migraine

DrugCorabotase

Ipsen

Phase 2

670

Brno, Choceň, Hradec Králové, Ostrava, Pardubice, Prague

2024-10-10

Active, closed

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)

NCT06516965Prurigo Nodularis

DrugPovorcitinib

Incyte Corporation

Phase 3

346

Prague

2024-10-10

Recruiting

Enhancing Palliative Care in ICU

NCT06605079Palliative Care

Charite University, Berlin, Germany

Not applicable

2,040

Prague

2024-10-10

Active, closed

A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

NCT06602479Migraine

AbbVie

Phase 2

309

Kladno, Prague, Rychnov nad Kněžnou

2024-10-07

Recruiting

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

NCT05947955Acute Respiratory Distress Syndrome, Infections

BioAegis Therapeutics Inc.

Phase 2

600

Brno, Prague

2024-10-03

Recruiting

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

NCT06510374Intermediate Risk Non-Muscle Invasive Bladder Cancer

DrugNadofaragene Firadenovec

Ferring Pharmaceuticals

Phase 3

454

Prague, Kroměříž, Liberec

2024-10-01

Recruiting

Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure

NCT06207383Atrial Fibrillation, Persistent, Heart Failure

University Hospital, Geneva

Not applicable

220

Prague

2024-10-01

Not yet open

NEUROMOdulation Pain Therapy in Combination With Intensive Physiotherapy

NCT05544175Spinal Cord

Charles University, Czech Republic

Not applicable

Prague

2024-10-01

Recruiting

A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer

NCT06545955Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

DrugsNadofaragene Firadenovec·Docetaxel·Gemcitabine·Pembrolizumab

Ferring Pharmaceuticals

Phase 3

250

Liberec, Prague, Kroměříž

2024-10-01

Not yet open

The Role of Pre-Surgical Tru - Cut Biopsy in the Management of Atypical Myometrial Lesions

NCT06521060Leiomyosarcoma

Charles University, Czech Republic

Observational

250

Prague

2024-10

By invitation

Open-Label Extension Study to Assess GLM101 in PMM2-CDG Patients

NCT06657859Pmm2-CDG, Phosphomannomutase 2 Deficiency

Glycomine, Inc.

Phase 2

Prague

2024-09-30

Active, closed

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

NCT06492616Breast Cancer

DrugsElacestrant·Tamoxifen·Exemestane·Anastrozole

Stemline Therapeutics, Inc.

Phase 3

4,556

Brno, Hořovice, Prague

2024-09-27

Active, closed

A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

NCT06238622Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis

DrugNerandomilast

Boehringer Ingelheim

Phase 3

1,666

Prague

2024-09-26

Active, closed

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

NCT06525220Head and Neck Squamous Cell Carcinoma

DrugsPetosemtamab·Pembrolizumab

Genmab

Phase 3

699

Olomouc, Prague

2024-09-25

Active, closed

A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy

NCT06481891Obstructive Cardiomyopathy, Hypertrophic, Non-obstructive Hypertrophic Cardiomyopathy

DrugSotagliflozin

Lexicon Pharmaceuticals

Phase 3

500

Brno, Prague, Ústí nad Labem

2024-09-24

Active, closed

To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications

NCT06553027Parkinson Disease

Cerevance

Phase 3

330

Pardubičky, Prague, Brno, Hradec Králové

2024-09-20

Recruiting

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

NCT06635148Geographic Atrophy, Macular Degeneration

Janssen Research & Development, LLC

Phase 2/3

274

Prague

2024-09-19

Active, closed

A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis

NCT06431373Uveitis, Posterior, Uveitis, Intermediate, Uveitis

Priovant Therapeutics, Inc.

Phase 3

371

Prague

2024-09-11

Recruiting

Clinical Performance of Medical Device Software "Lipidica 1.0" for Processing Data Generated by Lipidomic Analysis in Pancreatic Cancer Screening

NCT06549725Pancreas Cancer, Pancreatic Ductal Adenocarcinoma, Hereditary Diseases, Pancreatitis, Chronic

Lipidica, a.s.

Not applicable

419

Prague, Brno, České Budějovice, Hradec Králové, Jablonec nad Nisou, Olomouc, Pardubice, Pilsen

2024-09-10

Recruiting

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

NCT06548542Crohn's Disease

DrugsTrosunilimab·Lutikizumab·Risankizumab

AbbVie

Phase 2

590

Hradec Králové, Prague, Brno

2024-09-04

Active, closed

A Study of TAK-279 in Participants With Moderate-to-Severe Plaque Psoriasis

NCT06550076Plaque Psoriasis

DrugZasocitinib

Takeda

Phase 3

2,099

Náchod, Nový Jičín, Ostrava, Olomouc, Pardubice, Brno, Prague

2024-09-04

Active, closed

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

NCT06581198Lupus Erythematosus, Systemic, Lupus Nephritis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 2

179

Olomouc, Prague

2024-09-04

Recruiting

Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

NCT06274801Pulmonary Arterial Hypertension

Gossamer Bio USA, Inc.

Phase 3

330

Prague

2024-09-03

Not yet open

Use of Wearables to Detect Infections in Kidney Transplant Recipients

NCT06364618Kidney Transplant Infection

Institute for Clinical and Experimental Medicine

Observational

200

Prague

2024-09-01

Active, closed

A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients With Antibody-Mediated Rejection (AMR)

NCT06503731Antibody-mediated Rejection

argenx

Phase 2

Prague

2024-08-30

Active, closed

A Phase 2a/b Study of the Efficacy and Safety of Subcutaneous Amlitelimab in Adults With Nonresponsive Celiac Disease

NCT06557772Coeliac Disease, Celiac Disease

DrugAmlitelimab

Sanofi

Phase 2

229

Brno, Havířov, Klatovy, Prague

2024-08-29

Active, closed

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)

NCT06486441Endometrial Cancer

DrugsAdriamycin·Sacituzumab Govitecan·Taxol·Doxorubicin

Gilead Sciences

Phase 3

640

Nový Jičín, Ostrava-Poruba, Prague

2024-08-28

Active, closed

A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)

NCT06564311Relapsing Multiple Sclerosis

DrugObexelimab

Zenas BioPharma (USA), LLC

Phase 2

Brno, Jihlava, Prague

2024-08-26

Recruiting

Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure

NCT06331208Heart Failure, Pulmonary Hypertension, Pulmonary Vascular Resistance Abnormality

Institute for Clinical and Experimental Medicine

Observational

230

Prague

2024-08-23

Recruiting

Metabolic Response to the Initiation of Heart Failure Therapy

NCT06283420Heart Failure

Vojtech Melenovsky, MD, PhD

Observational

120

Prague

2024-08-23

Recruiting

A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT06290141Chronic Inflammatory Demyelinating Polyneuropathy

DrugsRiliprubart·IVIG

Sanofi

Phase 3

160

Brno, Hradec Králové, Ostrava, Pardubice, Prague

2024-08-21

Recruiting

Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

NCT06096116Acquired Antithrombin Deficiency

Octapharma

Phase 3

120

Brno, Prague

2024-08-21

Recruiting

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

NCT06371417Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)

DrugRAY121

Chugai Pharmaceutical

Phase 1

144

Prague

2024-08-19

Recruiting

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

NCT06395103B-cell Acute Lymphoblastic Leukemia, Diffuse Large B-cell Lymphoma, Burkitt Lymphoma, Neuroblastoma

DrugZilovertamab vedotin

Merck Sharp & Dohme LLC

Phase 1/2

Brno, Prague

2024-08-16

Recruiting

A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease

NCT06540833Psychotic Disorders, Alzheimer Disease

DrugITI-1284

Intra-Cellular Therapies, Inc.

Phase 2

370

Brno, Hradec Králové, Prague

2024-08-15

Active, closed

A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

NCT06508658Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Lenalidomide·Rituximab·Oxaliplatin

Genmab

Phase 3

379

Hradec Králové, Prague, Olomouc

2024-08-13

Recruiting

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

NCT06467357Biliary Tract Cancer

DrugsRilvegostomig·Trastuzumab deruxtecan·Durvalumab·Gemcitabine

AstraZeneca

Phase 3

620

Brno, Hradec Králové, Olomouc, Prague

2024-08-12

Recruiting

A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

NCT06549595Untreated Follicular Lymphoma

DrugsSurovatamig·R-Chop

AstraZeneca

Phase 3

1,018

Brno, Hradec Králové, Prague

2024-08-07

Active, closed

A Study to Evaluate the Efficacy and Safety of 2 Doses of Remigromig (EYE103) Compared With Ranibizumab (0.5 mg) in Participants With DME

NCT06571045Diabetic Macular Edema (DME)

DrugsRemigromig·Lucentis·Ranibizumab

EyeBiotech Ltd.

Phase 2/3

984

Mladá Boleslav, Náchod, Prague

2024-08-07

Recruiting

Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

NCT06480383Generalized Anxiety Disorder

DrugITI-1284

Intra-Cellular Therapies, Inc.

Phase 2

705

Brno, Pilsen, Prague

2024-08-05

Active, closed

Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension

NCT06492291Hypercholesterolemia

DrugsEnlicitide·Enlicitide Decanoate

Merck Sharp & Dohme LLC

Phase 3

3,000

Brno, Prague

2024-08-05

Active, closed

Iptacopan in Patients With ANCA Associated Vasculitis

NCT06388941Anti-Neutrophil Cytoplasm Antibodies (ANCA) Associated Vasculitis

DrugsIptacopan·Rituximab

Novartis Pharmaceuticals

Phase 2

Prague

2024-08-05

Recruiting

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

NCT06380751Advanced Breast Cancer

DrugsSaruparib·Camizestrant·Exemestane·Anastrozole

AstraZeneca

Phase 3

788

Brno, Hořovice, Hradec Králové, Olomouc, Prague

2024-08-01

By invitation

A Prospective Non-interventional Observational Study to Observe Long-term Treatment and Outcomes in Pulmonary Arterial Hypertension (PAH) Patients

NCT06445673Pulmonary Arterial Hypertension

AOP Orphan Pharmaceuticals AG

Observational

110

Olomouc, Prague

2024-07-31

Recruiting

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

NCT06216301Metastatic Non-small Cell Lung Cancer

DrugPembrolizumab

NovoCure GmbH

Phase 3

734

Olomouc, Ostrava, Prague

2024-07-31

Active, closed

A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy

NCT06440967Hot Flashes

DrugsFezolinetant·Tamoxifen

Astellas Pharma Global Development, Inc.

Phase 3

982

České Budějovice, Hořovice, Hradec Králové, Nový Jičín, Olomouc, Prague, Tábor, Vodňany

2024-07-31

Active, closed

A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)

NCT06510816Geographic Atrophy

DrugVonaprument

Annexon, Inc.

Phase 3

659

Prague

2024-07-30

By invitation

Long-term Safety and Tolerability of Cenerimod in Adults With Systemic Lupus Erythematosus

NCT06475742Lupus Erythematosus, Systemic

DrugCenerimod

Viatris Innovation GmbH

Phase 3

680

Brno, Prague

2024-07-30

By invitation

Long-term Safety and Tolerability of BHV-7000

NCT06443463Focal Epilepsy

DrugOpakalim

Biohaven Therapeutics Ltd.

Phase 2

660

Prague, Brno

2024-07-30

Recruiting

CellFX® Nanosecond Pulsed Field Ablation (PFA) 360 Catheter Ablation System for Treatment of Atrial Fibrillation

NCT06696170Atrial Fibrillation Paroxysmal, Cardiac Ablation, Cardiac Arrhythmia

Pulse Biosciences, Inc.

Not applicable

Prague

2024-07-25

Active, closed

The Field PULSE Study

NCT06452589Atrial Arrhythmias

Field Medical

Not applicable

Prague

2024-07-25

Recruiting

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

NCT06559306Depressive Disorder, Major

DrugSeltorexant

Janssen Research & Development, LLC

Phase 3

752

Brno, Pilsen, Prague

2024-07-25

Recruiting

Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

NCT06282575Biliary Tract Cancer

DrugsZanidatamab·Durvalumab·Gemcitabine·Cisplatin

Jazz Pharmaceuticals

Phase 3

286

Brno, Hradec Králové, Prague

2024-07-19

Active, closed

Scanning the Meiotic Spindle in Assisted Reproductive Techniques to Assess Oocyte Quality

NCT06539585Infertility, Infertility, Male, Infertility, Female

Charles University, Czech Republic

Not applicable

164

Prague

2024-07-18

Recruiting

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

NCT06226883Inflammatory Bowel Diseases, Crohn's Disease

DrugZotemtegrast

Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

Phase 2

385

Brno, Prague

2024-07-18

Recruiting

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

NCT06252649Metastatic Colorectal Cancer

DrugsLumakras·Sotorasib·Panitumumab·Bevacizumab-awwb

Amgen

Phase 3

450

Brno, Hradec Králové, Olomouc, Prague

2024-07-17

Recruiting

TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias

NCT07798674Hereditary Spastic Paraplegia, Spastic Ataxia

Heidelberg University

Observational

4,000

Prague

2024-07-16

Recruiting

Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors

NCT06680791Endometrial Cancer, Genetic Predisposition, Risk Behavior

Lukas Vanek

Observational

280

Prague

2024-07-15

Active, closed

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

NCT06445023Chronic Spontaneous Urticaria

DrugBarzolvolimab

Celldex Therapeutics

Phase 3

963

Prague

2024-07-11

Active, closed

Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

NCT06293365Sjögrens Disease, Systemic Lupus Erythematosus, Rheumatoid Arthritis

DrugIanalumab

Novartis Pharmaceuticals

Phase 2

155

Brno, Prague, Uherské Hradiště

2024-07-02

Active, closed

Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)

NCT06331312Polymyalgia Rheumatica

DrugSecukinumab

Novartis Pharmaceuticals

Phase 3

162

Prague, Brno, Hlučín, Uherské Hradiště

2024-06-28

Active, closed

A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

NCT06468228Hidradenitis Suppurativa

DrugLutikizumab

AbbVie

Phase 3

1,400

Ostrava, Karlovy Vary, Prague

2024-06-27

Active, closed

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

NCT06118281Cardiovascular Risk, Acute Myocardial Infarction (AMI)

DrugZiltivekimab

Novo Nordisk A/S

Phase 3

10,000

Liberec, Ústní Nad Labem, Brno, České Budějovice, Olomouc, Pardubice, Plzen - Lochotín, Prague

2024-06-25

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Czech investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 12 November 2026. https://priyalifescience.com/clinical-trials-czechia/city/prague

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Czechia and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 1,513 studies in total at the last sync on 11 Nov 2026, 03:18 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,080 of those studies with a site in Prague.

How many clinical trials are recruiting in Prague?

533 of the 1,080 studies on this page are recruiting new participants as of the 11 Nov 2026, 03:18 UTC sync. A further 36 have not yet opened recruitment, 473 are active but closed to new participants, and 38 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Prague), 1,080 studies
Phase	Studies	Recruiting	Share
Phase 3	566	236	52.4%
Phase 2	141	62	13.1%
Observational	140	98	13%
Not applicable	138	82	12.8%
Phase 2/3	37	22	3.4%
Phase 4	24	15	2.2%
Phase 1/2	23	12	2.1%
Phase 1	10	6	0.9%
Early Phase 1	1	0	0.1%

Most active sponsors

Lead sponsors with the most studies (Prague)
Lead sponsor	Studies	Recruiting
Charles University, Czech Republic	51	23
Novartis Pharmaceuticals	50	24
AstraZeneca	42	18
Janssen Research & Development, LLC	42	15
Eli Lilly and Company	40	15
Merck Sharp & Dohme LLC	39	20
Sanofi	34	12
Pfizer	33	18
AbbVie	28	7
Bristol-Myers Squibb	26	11

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.