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Clinical Trials in Czechia / NCT07033091
Recruiting Not applicable

Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening

NCT07033091 · tracked via the Priya Life Science Czechia tracker
Sponsor
The Institute of Molecular and Translational Medicine, Czech Republic
Phase
Not applicable
Started
2025-06-01
Last updated
2026-02-13

Condition(s) studied

Oropharynx Cancer

Investigational drug(s) / intervention(s)

Self-sampling by gargling kit at dental clinicQuestionnaireSelf-sampling by gargling kit at homeBlood samplingSelf-sampling of the urogenital area

Self-sampling by gargling kit at dental clinic: Participants will perform a self-sampling at the dental clinic using gargling kit

Questionnaire: Participants will answer questionnaire online/paper at their home or at the dental clinic

Self-sampling by gargling kit at home: Participants will perform a self-sampling at home using gargling kit

Blood sampling: Venous blood will be collected from study participants with oral hrHPV positivity, in which the presence of circulating hrHPV DNA will be determined.

Self-sampling of the urogenital area: In case of a positive examination in the oropharynx, the tested individuals will be offered a self-collection HPV examination in the urogenital area (cervicovaginal swab in women or external genital swab in men).

Study summary

This study defines the prevalence of oral infection with high-risk human papillomaviruses (hrHPV) in individuals over 40 years of age in the Czech Republic. It also establishes an effective methodology for oropharyngeal carcinoma screening and optimization of screening and testing procedures.

Eligibility

Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Participants aged 40 years or older at the time of enrollment. * Individuals who are capable of rinsing the oral cavity by gargling independently. * Signed informed consent for study participation, molecular-genetic testing, and personal data processing. Exclusion Criteria: \- Previously diagnosed head and neck cancer.

Primary outcome measure(s)

Trial sites (5)

FacilityCityRegionStatus
Masaryk Memorial Cancer Institute Brno Czechia Not Yet Recruiting
Stomatologická klinika, Fakultní nemocnice u sv. Anny Brno Czechia Recruiting
Stomatologické centrum ARTDENT s.r.o. Jihlava Czechia Recruiting
Klinika zubního lékařství Fakultní nemocnice Olomouc Olomouc Czechia Recruiting
CLINIQ Dejvice Prague Czechia Recruiting

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Self-sampling for Non-attenders to Cervical Cancer Screening Recruiting

Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07033091 on ClinicalTrials.gov ↗ ← All trials in Czechia