Clinical Trials in Czechia / NCT06683742
Active, not recruiting
Phase 3
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
NCT06683742 · tracked via the Priya Life Science Czechia tracker
Condition(s) studied
Wet Age Related Macular DegenerationwAMD
Investigational drug(s) / intervention(s)
EYP-1901: Intravitreal Injection
Aflibercept (2.0 mg): Intravitreal Injection
Study summary
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Eligibility
Inclusion Criteria:
* Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit.
* Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1).
* For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.
Exclusion Criteria:
* Subfoveal fibrosis, atrophy, or scarring in the center subfield.
* BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.
Primary outcome measure(s)
- Average change in best corrected visual acuity (BCVA) — Weeks 52 and 56
Trial sites (113)
| Facility | City | Region | Status |
|---|---|---|---|
| Associated Retina Consultans | Gilbert | Arizona | |
| Associated Retina Consultants - Phoenix | Phoenix | Arizona | |
| Phoenix Retina Clinical Trials, LLC | Phoenix | Arizona | |
| Retina Macula Institute of Arizona | Scottsdale | Arizona | |
| Win Retina | Arcadia | California | |
| Doctor Retina, PC | Beverly Hills | California | |
| The Retina Partners | Encino | California | |
| RCOC Clinical Research Institute Inc. | Fullerton | California | |
| Global Research Management, Inc. | Glendale | California | |
| Atlantis Eyecare | Huntington Beach | California | |
| South Coast Retina Center | Long Beach | California | |
| Retinal Consultants Medical Group | Modesto | California | |
| Northern California Retina Vitreous Associates Medical Group INC. | Mountain View | California | |
| Kaiser Permanente | Oakland | California | |
| California Retina Consultants Oxnard Office | Oxnard | California | |
| California Eye Specialists Medical Group, Inc. | Redlands | California | |
| Retina Consultants of Southern California | Redlands | California | |
| VRMG Inc | Sacramento | California | |
| Bay Area Retina Associates | Walnut Creek | California | |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | |
| RSC Research, PLLC | Denver | Colorado | |
| Eye Center of Northern Colorado, PC | Fort Collins | Colorado | |
| Colorado Retina Associates | Lakewood | Colorado | |
| Connecticut Eye Consultants, P.C. | Danbury | Connecticut | |
| SightSera Clinical Research LLC | Greenwich | Connecticut | |
| Blue Ocean Clinical Research | Clearwater | Florida | |
| Rand Eye Institute | Deerfield Beach | Florida | |
| Retina Group of Florida | Fort Lauderdale | Florida | |
| The Eye Institute of West Florida | Largo | Florida | |
| Retina Care Specialists | Palm Beach Gardens | Florida | |
| Fort Lauderdale Eye Institute | Plantation | Florida | |
| MedEye Associates | South Miami | Florida | |
| Retina Vitreous Associates of Florida - Saint Petersburg | St. Petersburg | Florida | |
| East Florida Eye Institute | Stuart | Florida | |
| Retina Specialists of Tampa | Tampa | Florida | |
| Gailey Eye Clinic | Bloomington | Illinois | |
| Retina Associates | Elmhurst | Illinois | |
| Illinois Retina Associates, S.C. | Oak Park | Illinois | |
| 3RP/ Windy City Retina | Plainfield | Illinois | |
| AVRUC | Carmel | Indiana |
+ 73 more sites — see the full list on the official registry below.
More EyePoint Pharmaceuticals, Inc. trials in Czechia
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06683742 on ClinicalTrials.gov ↗ ← All trials in Czechia