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Clinical Trials in Czechia / NCT07527156
Recruiting Phase 4

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

NCT07527156 · tracked via the Priya Life Science Czechia tracker
Sponsor
Institute for Clinical and Experimental Medicine
Phase
Phase 4
Started
2026-04-04
Last updated
2026-04-14

Condition(s) studied

Acute Heart Failure (AHF)Cardiogenic ShockHeart FailureKetonesKetone Body Metabolism

Investigational drug(s) / intervention(s)

Ketone Monoester (KE)

Ketone Monoester (KE): Continous infusion of a commercially available ketone monoester via nasogastric tube.

Study summary

This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * LVEF \<35% * Acute heart failure with low cardiac output syndrome or cardiogenic shock Exclusion Criteria: * Severe liver failure * Severe acidosis * Inability to insert nasogastric tube * Gastric paralysis / ileus * Repeated vomiting * Severe hypokalemia

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Institute for Clinical and Experimental Medicine (IKEM) Prague Prague Recruiting

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Other trials for the same condition

A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy Recruiting
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart Recruiting
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF) Recruiting
Alleviant ALLAY-HF Study Recruiting
Multimodal Cardiac Imaging Registry in Patients with Atrial Fibrillation Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07527156 on ClinicalTrials.gov ↗ ← All trials in Czechia