Pericoronary Adipocyte Size Gradient

NCT07360925 · tracked via the Priya Life Science Czechia tracker

Sponsor

Institute for Clinical and Experimental Medicine

Phase

Observational

Started

2023-06-01

Last updated

2026-01-22

Condition(s) studied

Heart FailureHeart Transplantation

Investigational drug(s) / intervention(s)

Heart transplantation for the final stage of heart failure

Heart transplantation for the final stage of heart failure: The study population comprises patients who underwent heart transplantation for heart failure at the Institute for Clinical and Experimental Medicine, Cardiovascular Surgery Department, between June 2023 and December 2028. Only the subjects' retrospective clinical data and matching heart samples will be analyzed.

Study summary

Evaluation of pericoronary adipocyte gradient (PCAT) in relationship with local atherosclerotic changes in a patient undergoing heart transplantation.

Eligibility

Sex

ALL

Min age

30 Years

Max age

90 Years

Healthy volunteers

Inclusion Criteria: * Age 30-90 years * Diagnosis of dilatational or ischemic cardiomyopathy * Patients undergoing heart transplantation in IKEM Exclusion Criteria: * Known combined diagnosis of dilatational and ischemic cardiomyopathy * Arrhythmogenic cardiomyopathy * Congenital heart defects * Non-eligibility due to the absence of informed consent

Primary outcome measure(s)

Adipocyte size — Perioperative/Periprocedural
Assessment of the difference (in square micrometer) between adipocyte size closely adjacent to the coronary artery and those more distant from the arterial lumen in relation to atherosclerotic pathologies in situ

Trial sites (1)

Facility	City	Region	Status
Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine,	Prague	Czechia	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07360925 on ClinicalTrials.gov ↗ ← All trials in Czechia