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Trackers› Clinical trials› Maryland
Clinical trial register · United States · industry-sponsored

Clinical Trials in Maryland, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9125 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 08 Oct 2026, 03:16 UTC
9125
Studies in scope
industry-sponsored, all four open statuses
4951
Recruiting now
open to new participants
2192
Lead sponsors
across recruiting studies
Top states
California 5301 Florida 4437 Illinois 2482 Georgia 2367 Arizona 2241
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca78 Novartis Pharmaceuticals31 Merck Sharp & Dohme LLC29 Eli Lilly and Company28 Pfizer28
State
California5301 Florida4437 Illinois2482 Georgia2367 Arizona2241
All 51 states
Target enrolment
to

Trials with a site in Maryland

1265 of 9125 studies
Download
Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
A Post-Authorization, Long-term Study of Ozanimod Real-world Safety
NCT05605782Multiple Sclerosis, Relapsing-Remitting
Bristol-Myers Squibb
Observational
9,000
Maryland
2021-09-02
Active, closed
A Study of ARV-766 Given by Mouth in Men With Metastatic Prostate Cancer
NCT05067140Prostate Cancer Metastatic
DrugsLuxdegalutamide·Abiraterone·Prednisolone·Prednisone
Novartis Pharmaceuticals
Phase 1/2
164
California, Connecticut, Florida, Maryland, Massachusetts, Michigan, New York, Pennsylvania
2021-09-02
Active, closed
A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease
NCT04929210Arthritis, Psoriatic
DrugsTremfya·Guselkumab
Janssen Research & Development, LLC
Phase 4
411
Arizona, Arkansas, California, Connecticut, Florida, Illinois, Maryland, Michigan
2021-08-30
Active, closed
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
NCT04923893Multiple Myeloma
DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine
Janssen Research & Development, LLC
Phase 3
743
California, Connecticut, Florida, Iowa, Kentucky, Maryland, Massachusetts, Michigan
2021-08-19
Active, closed
Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
NCT04938817Small Cell Lung Carcinoma
DrugsMK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab·R-DXd
Merck Sharp & Dohme LLC
Phase 1/2
110
Arizona, Georgia, Indiana, Kentucky, Maryland, Nebraska, Ohio, Pennsylvania
2021-08-19
Active, closed
Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)
NCT04976634Neoplasm Malignant
DrugsBelzutifan·Lenvatinib·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 2
730
Arizona, California, Connecticut, District of Columbia, Florida, Maryland, Michigan, New York
2021-08-18
Active, closed
Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma
NCT04674683Unresectable or Metastatic Melanoma, Progressive Brain Metastasis
DrugsChidamide·Nivolumab
HUYABIO International, LLC.
Phase 3
450
California, Florida, Indiana, Kentucky, Maryland, Missouri, Montana, North Carolina
2021-08-12
Recruiting
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
NCT04924075Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor, Von Hippel-Lindau Disease, Advanced Gastrointestinal Stromal Tumor
DrugBelzutifan
Merck Sharp & Dohme LLC
Phase 2
355
California, Illinois, Iowa, Maryland, Massachusetts, Michigan, Missouri, New York
2021-08-12
Active, closed
Study to Evaluate the Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases
NCT04640142Primary Immune Deficiency
Octapharma
Phase 3
50
California, Colorado, Florida, Illinois, Kansas, Kentucky, Maryland, Missouri
2021-08-04
Active, closed
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
NCT04790370Pulmonary Embolism
DrugsLMWH·Heparin
Boston Scientific Corporation
Phase 4
544
Alabama, California, Delaware, Georgia, Indiana, Kentucky, Maryland, Massachusetts
2021-08-02
Recruiting
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618C3G
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
98
Colorado, Florida, Georgia, Indiana, Iowa, Maryland, Massachusetts, New Jersey
2021-07-28
Recruiting
A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications
NCT04877288Renal Allograft Recipients
DrugsCyclosporine A·Belatacept·Mycophenolate Mofetil·Tacrolimus
Bristol-Myers Squibb
Phase 3
102
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Maryland, Massachusetts
2021-07-21
Active, closed
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment
NCT04908189Psoriatic Arthritis
DrugsApremilast·Deucravacitinib
Bristol-Myers Squibb
Phase 3
729
Alabama, California, Illinois, Kentucky, Louisiana, Maryland, Michigan, Minnesota
2021-07-15
Active, closed
A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases
NCT04554914Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
DrugTabelecleucel
Pierre Fabre Medicament
Phase 2
190
California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, Minnesota
2021-07-14
Active, closed
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution
NCT05044819Lennox Gastaut Syndrome, Dravet Syndrome, Tuberous Sclerosis Complex
DrugCannabidiol
Jazz Pharmaceuticals
Phase 4
154
Arkansas, California, Florida, Georgia, Kansas, Kentucky, Maryland, Massachusetts
2021-07-07
Active, closed
Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA
NCT04942210Yellow Fever, Healthy Volunteers
DrugYellow fever vaccine
Sanofi Pasteur, a Sanofi Company
Phase 2
568
Georgia, Louisiana, Maryland, Massachusetts, Missouri, Nebraska, New York, Rhode Island
2021-07-01
Active, closed
Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer
NCT04906395Breast Cancer
DrugsTOL2506·Tamoxifen·Exemestane·Anastrozole
Tolmar Inc.
Phase 3
250
California, Colorado, Illinois, Kentucky, Maryland, Nebraska, New York, Ohio
2021-07-01
Active, closed
A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH)
NCT04783181Congenital Adrenal Hyperplasia
Adrenas Therapeutics Inc
Phase 1/2
8
Illinois, Maryland, Minnesota, North Carolina, Pennsylvania
2021-07-01
Recruiting
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
NCT04965675Chronic Migraine in Children
DrugEptinezumab
H. Lundbeck A/S
Phase 3
285
Connecticut, District of Columbia, Florida, Georgia, Kentucky, Maryland, Michigan, New York
2021-06-30
Active, closed
A Study of Guselkumab in Participants With Active Psoriatic Arthritis
NCT04882098Arthritis, Psoriatic
DrugGuselkumab
Janssen Research & Development, LLC
Phase 3
1,054
Alabama, Arizona, California, Florida, Maryland, Michigan, Missouri, Montana
2021-06-17
Active, closed
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
NCT04768972Amyotrophic Lateral Sclerosis
Ionis Pharmaceuticals, Inc.
Phase 3
89
California, Maryland, Massachusetts, Missouri, New York, Ohio, Utah
2021-06-14
Recruiting
A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer
NCT04729114Prostate Cancer, Metastatic Castration Resistant Prostate Cancer, Metastatic Castration-sensitive Prostate Cancer
DrugsPRL-02·Enzalutamide·Prednisone·Dexamethasone
Astellas Pharma Global Development, Inc.
Phase 1
174
Arizona, California, Florida, Indiana, Kansas, Maryland, Nebraska, New Jersey
2021-06-14
Active, closed
Persona Ti-Nidium Post-Market Clinical Follow-up
NCT04817969Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
240
Colorado, Maryland, Mississippi, New Mexico, North Carolina, Pennsylvania, South Dakota
2021-06-01
Active, closed
Molecular Assessment and Profiling of Liver Transplant Recipients
NCT04793360Liver Transplantation, Biomarkers
CareDx
Observational
1,500
California, District of Columbia, Florida, Georgia, Kansas, Louisiana, Maryland, Massachusetts
2021-05-26
Active, closed
Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
NCT04544293Autoimmune Pulmonary Alveolar Proteinosis
DrugMolgramostim
Savara Inc.
Phase 3
164
Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Maryland
2021-05-19
Active, closed
A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation
NCT04856982Amyotrophic Lateral Sclerosis Associated With a SOD1 Gene Mutation
DrugTofersen
Biogen
Phase 3
158
Arizona, California, Florida, Georgia, Illinois, Maryland, Massachusetts, Missouri
2021-05-17
Active, closed
Evaluation of the Safety and Effectiveness of Bilateral Exablate Ablation of the Pallidothalamic Tract (PTT) for the Treatment of the Motor Complications of Parkinson's Disease (PD)
NCT04728295Parkinson Disease
InSightec
Not applicable
50
California, Florida, Illinois, Maryland, New York
2021-05-14
Active, closed
A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.
NCT04835805Melanoma
DrugsBelvarafenib·Cobimetinib·Nivolumab
Genentech, Inc.
Phase 1
65
California, Colorado, Iowa, Maryland, Missouri, New York, Tennessee
2021-05-13
Active, closed
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092Diffuse Large B-cell Lymphoma
DrugsTafasitamab·Vincristine·Doxorubicin·Prednisone
Incyte Corporation
Phase 3
899
Alabama, California, Colorado, Florida, Hawaii, Kansas, Kentucky, Maryland
2021-05-11
Active, closed
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
NCT04675333Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
DrugsEvorpacept·Cisplatin/Carboplatin·Fluorouracil·Keytruda
ALX Oncology Inc.
Phase 2
172
California, Florida, Illinois, Kentucky, Maryland, New York, Ohio, Oregon
2021-05-10
Active, closed
Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer
DrugsCapivasertib·Abemaciclib·Ribociclib·Palbociclib
AstraZeneca
Phase 3
893
Arizona, California, Colorado, Connecticut, Delaware, Kentucky, Maryland, Massachusetts
2021-05-10
Recruiting
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
NCT04614103Metastatic Non Small Cell Lung Cancer
Iovance Biotherapeutics, Inc.
Phase 2
170
Arizona, Florida, Illinois, Kentucky, Maryland, Michigan, Minnesota, Nebraska
2021-05-07
Recruiting
A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
NCT04830137Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Waldenstrom Macroglobulinemia (WM), Mantle Cell Lymphoma (MCL)
Nurix Therapeutics, Inc.
Phase 1
248
California, Colorado, Florida, Illinois, Maryland, New York, Ohio, Tennessee
2021-05-05
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
NCT04777357Depression, Bipolar I Disorder
DrugCariprazine
AbbVie
Phase 3
380
Arkansas, California, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland
2021-04-28
Recruiting
Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
NCT03708900Cushing Syndrome
DrugOsilodrostat
RECORDATI GROUP
Phase 2
12
California, Florida, Illinois, Maryland, Texas
2021-04-28
Active, closed
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
NCT04784715Breast Cancer; HER2-positive; Metastatic
DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab
AstraZeneca
Phase 3
1,157
Arizona, Arkansas, California, Colorado, Florida, Georgia, Kentucky, Maryland
2021-04-26
Recruiting
ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)
NCT04883905Acute Hepatic Porphyria
Alnylam Pharmaceuticals
Observational
150
Alabama, Arizona, California, Maryland, Massachusetts, Minnesota, New York, North Carolina
2021-04-26
Recruiting
A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
NCT04775485Low-grade Glioma, Advanced Solid Tumor
DrugTovorafenib
Day One Biopharmaceuticals, Inc.
Phase 2
141
California, District of Columbia, Illinois, Maryland, Massachusetts, Michigan, Missouri, New York
2021-04-22
Recruiting
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
NCT04159103Propionic Acidemia
DrugMRNA-3927
ModernaTX, Inc.
Phase 1/2
77
California, Florida, Illinois, Maryland, Massachusetts, Michigan, New York, North Carolina
2021-04-15
Active, closed
Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion
NCT04794699Solid Tumor
DrugsIDE397·Sacituzumab Govitecan
IDEAYA Biosciences
Phase 1
169
Arizona, Arkansas, California, Florida, Indiana, Maryland, Massachusetts, New York
2021-04-14
Active, closed
Breast Cancer Index (BCI) Registry
NCT04875351Breast Cancer
Biotheranostics, Inc.
Observational
3,465
Alabama, Arizona, California, Colorado, Florida, Illinois, Maryland, New York
2021-04-14
Active, closed
Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
NCT04662255Lymphoma, Mantle-Cell
DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib
Loxo Oncology, Inc.
Phase 3
500
Alaska, Arizona, California, Colorado, Florida, Kentucky, Louisiana, Maryland
2021-04-08
Recruiting
Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment
NCT04617522Advanced or Metastatic Solid Tumor, Liver Failure
DrugSacituzumab Govitecan
Gilead Sciences
Phase 1
30
California, Delaware, Maryland, Texas
2021-04-06
Active, closed
Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
NCT04675294Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
DrugsEvorpacept·Keytruda·Pembrolizumab
ALX Oncology Inc.
Phase 2
189
California, Florida, Georgia, Illinois, Maryland, Massachusetts, New Jersey, New York
2021-04-02
Recruiting
A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes
NCT04786262Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness, Severe Hypoglycemia
DrugZimislecel
Vertex Pharmaceuticals Incorporated
Phase 3
57
California, Florida, Illinois, Maryland, Massachusetts, Pennsylvania, Texas, Virginia
2021-03-29
Active, closed
Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection
NCT04727788Kidney Transplant Rejection
Verici Dx
Observational
550
Illinois, Maryland, Michigan, Nebraska, Ohio, Pennsylvania, Tennessee, Washington
2021-03-21
Active, closed
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer
NCT04691804Metastatic Castration-Resistant Prostate Cancer (mCRPC)
DrugFluzoparib
Jiangsu HengRui Medicine Co., Ltd.
Phase 3
496
Alaska, Arizona, California, Florida, Louisiana, Maryland, Michigan, Nebraska
2021-03-18
Active, closed
Adjuvant PRGN-2012 in Adult Patients With Recurrent Respiratory Papillomatosis
NCT04724980Recurrent Respiratory Papillomatosis, Papillomavirus Infections, Papillomaviridae
Precigen, Inc
Phase 1/2
38
Maryland
2021-03-16
Active, closed
REgiStry Of the NAtural History of recurreNt periCarditis in pEdiatric and Adult Patients
NCT04687358Recurrent Pericarditis
Kiniksa Pharmaceuticals International, plc
Observational
500
Alaska, Arizona, California, Illinois, Iowa, Maryland, Massachusetts, Michigan
2021-03-16
Active, closed
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
NCT04562389Myelofibrosis
DrugsSelinexor·Ruxolitinib
Karyopharm Therapeutics Inc
Phase 3
353
Alabama, California, Colorado, Connecticut, District of Columbia, Kentucky, Maryland, Michigan
2021-03-11
Recruiting
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer
DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Durvalumab
AstraZeneca
Phase 1
304
California, Kansas, Maryland, Michigan, New York, Texas, Virginia, Washington
2021-03-09
Recruiting
Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors
NCT04777994Advanced Solid Tumor Cancer
Calico Life Sciences LLC
Phase 1
248
Arizona, Connecticut, Maryland, Massachusetts, Michigan, New York, North Carolina, Pennsylvania
2021-03-09
Active, closed
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
NCT04775082Obesity
DrugLiraglutide
Novo Nordisk A/S
Phase 3
78
Arizona, Colorado, Idaho, Louisiana, Maryland, Minnesota, New York, Ohio
2021-03-04
Active, closed
Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment
NCT04647526Metastatic Castration-Resistant Prostate Cancer
DrugsAbiraterone·Enzalutamide
POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company
Phase 3
455
Arizona, California, Colorado, Florida, Iowa, Kentucky, Louisiana, Maryland
2021-02-25
Active, closed
A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
NCT04408638Diffuse Large B-cell Lymphoma
DrugsRituxumab·Glofitamab·Tocilizumab·Obinutuzumab
Hoffmann-La Roche
Phase 3
270
Alabama, California, Florida, Maryland, Massachusetts, Mississippi, New Jersey, New York
2021-02-23
Active, closed
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
NCT04619004Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
DrugPatritumab deruxtecan
Daiichi Sankyo
Phase 2
277
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2021-02-02
Recruiting
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
NCT03127267Amyotrophic Lateral Sclerosis
DrugsMasitinib·Riluzole
AB Science
Phase 3
495
Alabama, California, Kentucky, Maryland, Massachusetts, Virginia
2021-02-02
Active, closed
Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
NCT04755283Atrial Fibrillation (AF), Stroke
DrugsAbelacimab·Rivaroxaban
Anthos Therapeutics, Inc.
Phase 2
1,287
Alabama, Connecticut, Florida, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2021-02-02
Active, closed
A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
NCT04711252ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Palbociclib
AstraZeneca
Phase 3
1,371
Alabama, Arkansas, California, Colorado, Florida, Indiana, Louisiana, Maryland
2021-01-28
Active, closed
Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
NCT04589845Solid Tumors
DrugsCamonsertib·Belvarafenib·Pralsetinib·Divarasib
Hoffmann-La Roche
Phase 2
920
Arizona, California, Georgia, Idaho, Illinois, Indiana, Maryland, Michigan
2021-01-18
Active, closed
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia
DrugBlinatumomab
Amgen
Phase 1/2
181
California, Illinois, Maryland, Michigan, New York, Pennsylvania, Tennessee, Texas
2021-01-04
Active, closed
MYLUNG Consortium Study Protocol 2
NCT05644808Carcinoma, Non-Small-Cell Lung
US Oncology Research
Observational
1,002
Alabama, Colorado, Florida, Illinois, Maryland, Minnesota, New York, Ohio
2020-12-29
Recruiting
Secukinumab Open Label Roll-over Extension Protocol
NCT04638647Autoimmunity, Inflammation
DrugSecukinumab
Novartis Pharmaceuticals
Phase 4
1,000
California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Nebraska
2020-12-22
Active, closed
A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation
NCT04625270Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer
DrugsAvutometinib (VS-6766) and defactinib·Avutometinib·Sotorasib
Verastem, Inc.
Phase 2
225
Arizona, California, Connecticut, Florida, Illinois, Maryland, Minnesota, Missouri
2020-12-21
Active, closed
Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)
NCT04656652Non-small Cell Lung Cancer
DrugsDato-DXd·Docetaxel
Daiichi Sankyo
Phase 3
605
Arizona, California, Florida, Illinois, Indiana, Kentucky, Louisiana, Maryland
2020-12-21
Active, closed
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
NCT04171492Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Biodesix, Inc.
Observational
2,000
Colorado, Connecticut, District of Columbia, Indiana, Maryland, Michigan, Minnesota, Missouri
2020-12-18
Active, closed
Beating Heart Mitral Valve Repair With the HARPOON™ System
NCT04375332Mitral Regurgitation
Edwards Lifesciences
Not applicable
25
California, Georgia, Maryland, Michigan, Minnesota, Oregon, Tennessee, Utah
2020-12-16
Active, closed
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
NCT04490915Congenital Adrenal Hyperplasia
DrugCrinecerfont
Neurocrine Biosciences
Phase 3
182
California, Colorado, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2020-12-16
Active, closed
A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease
NCT04540497IgG4 Related Disease
DrugInebilizumab
Amgen
Phase 3
135
California, Georgia, Maryland, Massachusetts
2020-12-04
Active, closed
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
NCT04622319HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
DrugsTrastuzumab emtansine·Trastuzumab deruxtecan
Daiichi Sankyo
Phase 3
1,600
California, Florida, Illinois, Kentucky, Louisiana, Maryland, New York, North Carolina
2020-12-04
Recruiting
A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease
NCT04671771End Stage Renal Disease (ESRD), Kidney Failure, Chronic Renal Disease, Hemodialysis
W.L.Gore & Associates
Not applicable
133
Arizona, Florida, Georgia, Kentucky, Maryland, Massachusetts, New Jersey, New York
2020-12-03
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
NCT04548999Multiple Sclerosis
DrugsOcrelizumab·Methylprednisolone
Hoffmann-La Roche
Phase 3
769
Alabama, Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts
2020-12-03
Active, closed
Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome
NCT04623541Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Treatment-naïve High Risk Chronic Lymphocytic Leukemia
DrugsEpcoritamab·Pirtobrutinib·Lenalidomide·Venetoclax
Genmab
Phase 1/2
194
Alabama, California, Florida, Maryland, Massachusetts, Michigan, New Jersey, New York
2020-11-25
Recruiting
ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)
NCT04561518Transthyretin-Mediated Amyloidosis, ATTR Amyloidosis
Alnylam Pharmaceuticals
Observational
1,500
California, Florida, Iowa, Kansas, Maryland, Massachusetts, New York, North Carolina
2020-11-23
Active, closed
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)
NCT04567550Diabetic Retinopathy (DR), Center-Involved Diabetic Macular Edema (CI-DME)
DrugAflibercept
AbbVie
Phase 2
139
Arizona, California, Georgia, Illinois, Maryland, Massachusetts, Nevada, New Jersey
2020-11-20
Active, closed
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)
NCT04512235AL Amyloidosis
DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)
Alexion Pharmaceuticals, Inc.
Phase 3
281
Arizona, California, Florida, Indiana, Louisiana, Maryland, Massachusetts, Michigan
2020-11-03
Recruiting
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
NCT04541082Central Nervous System Neoplasms, Glioblastoma, Gliosarcoma, Adult, Anaplastic Oligodendroglioma
DrugONC206
Jazz Pharmaceuticals
Phase 1
102
Maryland
2020-10-26
Active, closed
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
NCT04598893Diabetes Mellitus, Type 1
DrugTeplizumab
Provention Bio, a Sanofi Company
Observational
188
California, Colorado, Florida, Georgia, Idaho, Indiana, Iowa, Maryland
2020-10-26
Recruiting
The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation
NCT04494295Supratentorial Hemorrhage
Integra LifeSciences Corporation
Observational
500
California, Florida, Illinois, Maryland, Michigan, Missouri, New Jersey, New York
2020-10-23
By invitation
Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy
NCT04628585Sickle Cell Disease
Genetix Biotherapeutics Inc.
Observational
85
Alabama, California, Georgia, Illinois, Maryland, Minnesota, New Jersey, New York
2020-10-21
Active, closed
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
NCT04464226Cancer
DrugDarolutamide
Bayer
Phase 3
402
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Maryland
2020-10-20
Active, closed
CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC
NCT04495153Non Small Cell Lung Cancer
DrugAglatimagene besadenovec
Candel Therapeutics, Inc.
Phase 2
90
Arizona, Connecticut, Illinois, Maryland, Minnesota, New York, Ohio, Pennsylvania
2020-10-13
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Palbociclib·Letrozole
Hoffmann-La Roche
Phase 3
992
California, Colorado, Florida, Hawaii, Maryland, Massachusetts, Missouri, New Jersey
2020-10-09
Active, closed
Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations
NCT04521686Cholangiocarcinoma, Chondrosarcoma, Glioma, Any Solid Tumor
DrugsLY3410738·Durvalumab·Gemcitabine·Cisplatin
Eli Lilly and Company
Phase 1
200
Arizona, California, Florida, Illinois, Indiana, Maryland, Massachusetts, Minnesota
2020-10-01
Active, closed
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04487080Carcinoma, Non-Small-Cell Lung
DrugsLazertinib·Amivantamab·Osimertinib
Janssen Research & Development, LLC
Phase 3
1,074
Arizona, California, Colorado, Florida, Georgia, Louisiana, Maryland, Michigan
2020-09-30
Active, closed
Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)
NCT04526691Advanced or Metastatic NSCLC
DrugsDato-DXd·Keytruda·Cisplatin·Carboplatin
Daiichi Sankyo
Phase 1
145
Arizona, California, District of Columbia, Florida, Maryland, Minnesota, New Mexico, Texas
2020-09-15
Active, closed
A Unique Micro Water Jet Technology Device Versus Standard Debridement in the Treatment of Diabetic Foot
NCT04564443Diabetic Foot Ulcer, Diabetic Foot
Medaxis, LLC
Not applicable
222
California, Florida, Maryland, North Carolina, Ohio, Virginia
2020-09-11
Active, closed
A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
NCT04442022Relapsed/Refractory Diffuse Large B-cell Lymphoma
DrugsSelinexor·Rituximab·Dexamethasone·Gemcitabine
Karyopharm Therapeutics Inc
Phase 2/3
501
Arizona, California, Kentucky, Maryland, New York, Texas
2020-09-03
Recruiting
Hydrus® Microstent New Enrollment Post-Approval Study
NCT04553523Primary Open Angle Glaucoma
Alcon Research
Not applicable
545
California, Colorado, Iowa, Kansas, Maryland, Michigan, Minnesota, Missouri
2020-08-25
Active, closed
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)
NCT04514653Neovascular Age-Related Macular Degeneration (nAMD)
DrugRanibizumab
AbbVie
Phase 2
146
Arizona, California, Georgia, Illinois, Maryland, Massachusetts, Nevada, New Mexico
2020-08-25
Active, closed
Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL
NCT04404283Diffuse Large B-cell Lymphoma
DrugsBrentuximab Vedotin·Lenalidomide·Rituximab
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
239
Alabama, California, Florida, Kansas, Maryland, Michigan, Missouri, Ohio
2020-08-20
Recruiting
Ankle Robotics After Stroke
NCT04594837Foot Drop, Stroke, Hemiparesis
NextStep Robotics Inc.
Not applicable
140
Maryland
2020-08-20
Recruiting
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)
NCT04419649Myelodysplastic Syndromes, Cytopenia
DrugElritercept
Takeda
Phase 2
160
Arkansas, California, Florida, Maryland, Michigan, New Jersey, New York, Pennsylvania
2020-08-19
Recruiting
A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies
NCT04503265Advanced Malignant Neoplasm, Breast Cancer, Ovarian Cancer, Homologous Recombination Deficiency
DrugExpansion
AtlasMedx, Incorporated
Phase 1/2
122
California, Maryland, Tennessee, Texas
2020-08-12
Recruiting
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
NCT04300556Solid Tumor
DrugsPrednisolone·Lenvatinib·Prednisone·Dexamethasone
Eisai Inc.
Phase 1/2
182
Arizona, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Maryland
2020-08-06
Active, closed
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib
NCT04421963Ovarian Cancer, Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
185
Florida, Maryland, Michigan, Minnesota, New Jersey, New York, Pennsylvania, Rhode Island
2020-08-04
Active, closed
Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)
NCT04509700B-Cell Malignancies
DrugsItacitinib·Parsaclisib·Ibrutinib·Ruxolitinib
Incyte Corporation
Phase 2
112
Alabama, Arizona, California, Colorado, Illinois, Kansas, Maryland, Massachusetts
2020-08-03
Active, closed
Artoss Prospective Spine Registry Outcomes
NCT04439032Spinal Fusion
Artoss Inc.
Observational
330
Arizona, California, Connecticut, Maryland, Mississippi
2020-08-03
Active, closed
A Study to Test Different Doses of Obrixtamig in Patients With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3
NCT04429087Small Cell Lung Carcinoma and Other Neuroendocrine Neoplasms Expressing DLL3
DrugObrixtamig
Boehringer Ingelheim
Phase 1
306
Georgia, Maryland, Missouri, Pennsylvania
2020-07-29
Active, closed
A Phase III Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)
NCT04191304Hypereosinophilic Syndrome
DrugBenralizumab
AstraZeneca
Phase 3
134
California, Georgia, Maryland, Michigan, North Carolina, Ohio, Utah
2020-07-20
Active, closed
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
NCT04245839Lymphoma, Non-Hodgkin
DrugsLiso-cel·Fludarabine·Cyclophosphamide
Celgene
Phase 2
276
California, Colorado, Connecticut, Illinois, Iowa, Kansas, Maryland, Massachusetts
2020-07-14
Active, closed
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
NCT04493853Hormone-Sensitive Prostate Cancer
DrugsZytiga·Capivasertib·Abiraterone acetate
AstraZeneca
Phase 3
1,012
Arizona, California, Colorado, Connecticut, Florida, Illinois, Maryland, Michigan
2020-07-13
Active, closed
SELUTION SLR™ 014 In-stent Restenosis
NCT04280029Coronary Restenosis
M.A. Med Alliance S.A.
Not applicable
418
California, Colorado, District of Columbia, Florida, Georgia, Indiana, Kansas, Maryland
2020-07-06
Recruiting
Study of SX-682 Alone and in Combination With Oral or Intravenous Decitabine in Subjects With Myelodysplastic Syndrome
NCT04245397Myelodysplastic Syndromes
DrugsSX-682·Decitabine
Syntrix Biosystems, Inc.
Phase 1
151
Florida, Georgia, Maryland, New York
2020-06-30
Active, closed
Bilateral Treatment of Medication Refractory Essential Tremor
NCT04112381Essential Tremor
InSightec
Not applicable
51
California, Maryland, New York, Ohio, Pennsylvania, Virginia, West Virginia
2020-06-30
Active, closed
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
NCT04295811Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
Lucid Diagnostics, Inc.
Not applicable
784
Colorado, District of Columbia, Florida, Illinois, Louisiana, Maryland, Massachusetts, Michigan
2020-06-18
Active, closed
Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System
NCT04201132Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis
Contego Medical, Inc.
Not applicable
305
Alabama, California, District of Columbia, Florida, Iowa, Kentucky, Louisiana, Maryland
2020-06-12
Active, closed
A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)
NCT04404660Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia
DrugAUTO1
Autolus Limited
Phase 1/2
153
California, Colorado, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts
2020-06-03
Active, closed
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
NCT04379596Gastric Cancer
DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Fluorouracil
AstraZeneca
Phase 2
452
Maryland, Massachusetts, New York, Texas
2020-06-03
Active, closed
Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS
NCT04057898Amyotrophic Lateral Sclerosis
MediciNova
Phase 2/3
234
California, Florida, Georgia, Indiana, Maryland, Minnesota, New York, North Carolina
2020-05-28
Active, closed
The JenaValve ALIGN-AR Pivotal Trial
NCT04415047Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease
JenaValve Technology, Inc.
Not applicable
180
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Maryland, Michigan
2020-05-22
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
NCT04241185Urinary Bladder Neoplasms
DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda
Merck Sharp & Dohme LLC
Phase 3
520
District of Columbia, Florida, Kentucky, Maryland, Missouri, New Jersey, New York, Ohio
2020-05-19
Active, closed
Long-Term Prospective Registry in Prostate Cancer Patients From Diverse Urology Practice Settings Following Prolaris® Testing
NCT04404894Prostate Cancer
Myriad Genetic Laboratories, Inc.
Observational
500
Alabama, California, Florida, Illinois, Maryland, Tennessee
2020-04-30
Active, closed
Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer
NCT04305496Locally Advanced (Inoperable) or Metastatic Breast Cancer
DrugsCapivasertib·Fulvestrant
AstraZeneca
Phase 3
818
Arizona, California, Florida, Kansas, Maryland, Massachusetts, Minnesota, Missouri
2020-04-16
Active, closed
A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)
NCT03477604Peripheral Arterial Disease
Micro Medical Solution, Inc.
Not applicable
177
Alabama, Arizona, California, Colorado, Florida, Iowa, Louisiana, Maryland
2020-03-31
Active, closed
Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD
NCT04229017Degenerative Disc Disease
Providence Medical Technology, Inc.
Not applicable
236
Arizona, California, Colorado, Illinois, Kentucky, Louisiana, Maryland, Michigan
2020-03-18
Active, closed
GNOS-PV02 Personalized Neoantigen Vaccine, INO-9012 and Pembrolizumab in Subjects With Advanced HCC
NCT04251117HCC
DrugsGNOS-PV02·INO-9012·Pembrolizumab
Geneos Therapeutics
Phase 1/2
36
Maryland, New York
2020-03-01
Active, closed
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
NCT04195750Carcinoma, Renal Cell
DrugsBelzutifan·Everolimus
Merck Sharp & Dohme LLC
Phase 3
755
Alabama, California, Colorado, District of Columbia, Georgia, Illinois, Louisiana, Maryland
2020-02-27
Active, closed
Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer
NCT03937154Chemotherapy-induced Thrombocytopenia
DrugsNplate·Romiplostim
Amgen
Phase 3
145
Arkansas, California, Colorado, Florida, Idaho, Illinois, Louisiana, Maryland
2020-02-26
Active, closed
DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer
NCT04042701Breast Cancer, Non-small Cell Lung Carcinoma
DrugsTrastuzumab deruxtecan·Keytruda·Pembrolizumab
Daiichi Sankyo
Phase 1
115
California, Connecticut, Florida, Maryland, Massachusetts, Missouri, Pennsylvania, Texas
2020-02-10
Active, closed
Long-term Follow-up Study of Patients Receiving Onasemnogene Abeparvovec-xioi
NCT04042025Spinal Muscular Atrophy Type I, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy Type III, SMA
DrugsOnasemnogene Abeparvovec-xioi·Zolgensma
Novartis Gene Therapies
Phase 3
85
California, Colorado, Illinois, Maryland, Massachusetts, Michigan, Missouri, New York
2020-02-10
Active, closed
Optilume™ BPH Catheter System in Men With Symptomatic BPH
NCT04131907Benign Prostatic Hyperplasia
Urotronic Inc.
Not applicable
162
Arkansas, Colorado, Florida, Illinois, Louisiana, Maryland, Nevada, New Jersey
2020-02-05
Active, closed
TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations
NCT04129502Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
DrugsMobocertinib·Pemetrexed·Cisplatin·Carboplatin
Takeda
Phase 3
354
California, Florida, Illinois, Maryland, Massachusetts, Tennessee, Virginia
2020-01-10
Recruiting
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL
NCT04260022Leukemia, Myeloid, Chronic, Myeloid Leukemia, Chronic Myeloid Leukemia, Philadelphia Positive Acute Lymphoblastic Leukemia
DrugBlinatumomab
Ascentage Pharma Group Inc.
Phase 1
242
Alabama, California, Georgia, Maryland, Ohio, Texas, Washington
2020-01-09
Active, closed
A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer
NCT04165317Non-muscle Invasive Bladder Cancer
DrugsSasanlimab·Bacillus Calmette-Guerin
Pfizer
Phase 3
1,068
Arizona, Arkansas, California, Colorado, Florida, Illinois, Louisiana, Maryland
2019-12-30
Recruiting
KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)
NCT04165798Carcinoma, Non-Small-Cell Lung
Merck Sharp & Dohme LLC
Observational
1,065
Arizona, California, District of Columbia, Kentucky, Maryland, Massachusetts, Nebraska, New Hampshire
2019-12-19
Recruiting
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
NCT04165070Carcinoma, Non-Small-Cell Lung
DrugsMK-4830·Ifinatamab Deruxtecan·Patritumab deruxtecan·Abraxane
Merck Sharp & Dohme LLC
Phase 1/2
450
Arizona, California, District of Columbia, Kentucky, Maryland, Massachusetts, Nebraska, New Hampshire
2019-12-19
Active, closed
A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma
NCT04194775Hepatocellular Carcinoma
DrugLenvatinib
CStone Pharmaceuticals
Phase 3
534
California, Maryland, Massachusetts, New York
2019-12-13
Active, closed
A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer
NCT04188548Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, Endometrial Cancer
DrugsImlunestrant·Alpelisib·Everolimus·Abemaciclib
Eli Lilly and Company
Phase 1
379
Arizona, Arkansas, California, Florida, Georgia, Indiana, Maryland, Massachusetts
2019-12-10
Recruiting
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
NCT04197921Opioid-use Disorder, Substance Use Disorders
InSightec
Not applicable
29
Florida, Maryland, New York, West Virginia
2019-11-27
Active, closed
Study of RV001V in Biochemical Failure Following Curatively Intended Therapy For Localized Prostate Cancer
NCT04114825Prostate Cancer Recurrent
RhoVac APS
Phase 2
180
Florida, Maryland, Nebraska, Nevada, New York, South Carolina, Texas
2019-11-19
Active, closed
A Study of Tyrosine Kinase Inhibitor Orelabrutinib (ICP-022) in Patients With r/r B-Cell Malignancies
NCT04014205Part 1：r/r B-cell Malignancies, Part 2：B-cell Malignancies
DrugOrelabrutinib
Beijing InnoCare Pharma Tech Co., Ltd.
Phase 1/2
81
Arizona, California, Florida, Illinois, Indiana, Kansas, Louisiana, Maryland
2019-11-18
Recruiting
APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study
NCT05119842Paralysis, Unilateral, Vocal Cord
APrevent Biotech GmbH
Not applicable
30
Arizona, Maryland, Ohio, Texas
2019-11-13
Active, closed
A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer
NCT04025879Carcinoma, Non-Small-Cell Lung
DrugsOpdivo·Pemetrexed·Docetaxel·Nivolumab
Bristol-Myers Squibb
Phase 3
461
Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, New Hampshire, Ohio
2019-11-05
Active, closed
Pediatric Long-Term Follow-up and Rollover Study
NCT03975829Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood
DrugsDabrafenib·Trametinib
Novartis Pharmaceuticals
Phase 4
163
Arizona, District of Columbia, Florida, Indiana, Maryland, Massachusetts, Minnesota, New York
2019-11-04
By invitation
A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia
NCT04138927Warm Antibody Autoimmune Hemolytic Anemia
DrugFostamatinib
Rigel Pharmaceuticals
Phase 3
90
California, District of Columbia, Maryland, Massachusetts, Nevada, Washington
2019-10-30
Active, closed
Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors
NCT04041310Solid Tumor, Adult
DrugsKeytruda·Pembrolizumab
Nouscom SRL
Phase 1/2
115
California, Florida, Indiana, Maryland, Missouri, New York, Texas
2019-10-21
Active, closed
Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry
NCT04076813Myocardial Infarction
Chiesi USA, Inc.
Observational
5,050
California, Delaware, Florida, Idaho, Maryland, Massachusetts, Michigan, Missouri
2019-10-16
By invitation
A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)
NCT04093570Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes
DrugDecitabine
Taiho Oncology, Inc.
Phase 2
332
California, Florida, Illinois, Maryland, Michigan, Minnesota, New Jersey, New York
2019-09-30
Recruiting
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
NCT04104776Advanced Solid Tumor, Diffuse Large B Cell Lymphoma, Lymphoma, T-Cell, Mesothelioma, Malignant
DrugsTulmimetostat·Enzalutamide
Novartis Pharmaceuticals
Phase 1/2
300
Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, New Jersey, New York
2019-09-18
Active, closed
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
NCT04083599Malignant Solid Tumor, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Melanoma
DrugsGEN1042·Adrucil·Nab-paclitaxel·Pemetrexed
Genmab
Phase 1/2
350
Alaska, California, Connecticut, Delaware, Florida, Illinois, Kentucky, Maryland
2019-09-17
Active, closed
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
NCT04067336Advanced Malignant Neoplasm, Acute Myeloid Leukemia, Mixed Lineage Leukemia, Mixed Lineage Acute Leukemia
DrugsZiftomenib·Itraconazole·Midazolam
Kura Oncology, Inc.
Phase 1/2
263
Arizona, California, Florida, Illinois, Maryland, Massachusetts, Michigan, Minnesota
2019-09-12
Active, closed
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease
NCT04120493Huntington's Disease
UniQure Biopharma B.V.
Phase 1/2
43
Alabama, Arizona, California, Colorado, Illinois, Maryland, Michigan, Ohio
2019-09-06
Active, closed
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
NCT03950232Ulcerative Colitis
DrugEtrasimod
Pfizer
Phase 3
896
Alabama, California, Colorado, Florida, Georgia, Illinois, Louisiana, Maryland
2019-09-05
Active, closed
Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE III)
NCT04065490Dry Age-related Macular Degeneration
LumiThera, Inc.
Not applicable
96
California, Florida, Maryland, New Jersey, New York, North Carolina, Pennsylvania, Texas
2019-09-01
Active, closed
Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
NCT04044768Synovial Sarcoma, Myxoid Liposarcoma
USWM CT, LLC
Phase 2
52
California, Colorado, Florida, Illinois, Maryland, Massachusetts, Michigan, Missouri
2019-08-13
Recruiting
Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies
NCT04068597Haematological Malignancy, Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma
DrugsIxazomib·Elranatamab·Teclistamab·Pomalidomide
CellCentric Ltd.
Phase 1/2
250
Georgia, Indiana, Maryland, Nebraska, Pennsylvania
2019-08-09
Active, closed
Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma
NCT03937219Renal Cell Carcinoma
DrugsCabozantinib·Yervoy·Ipilimumab·Opdivo
Exelixis
Phase 3
855
California, Florida, Georgia, Illinois, Maine, Maryland, Massachusetts, Michigan
2019-06-25
Active, closed
Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)
NCT03944772Non-Small Cell Lung Cancer
DrugsNecitumumab·Gefitinib·Savolitinib·Selpercatinib
AstraZeneca
Phase 2
247
California, Connecticut, Illinois, Maryland, Massachusetts, Michigan, New York, Oregon
2019-06-25
Active, closed
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
NCT03997123Triple Negative Breast Neoplasms
DrugsCapivasertib·Paclitaxel
AstraZeneca
Phase 3
923
California, Florida, Illinois, Kansas, Maryland, Michigan, New York, Ohio
2019-06-25
Active, closed
Validation of ClarityDX Prostate as a Reflex Test to Refine the Prediction of Clinically-significant Prostate Cancer
NCT03957252Prostate Cancer, Prostate Cancer Screening, Performance Assessment of Novel Test
Nanostics
Observational
2,800
Maryland
2019-06-06
Active, closed
Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma
NCT03969004Cutaneous Squamous Cell Carcinoma
DrugCemiplimab
Regeneron Pharmaceuticals
Phase 3
415
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Maryland
2019-06-04
By invitation
Long-term Follow-Up Study of RGX-314 and Fellow Eye Substudy
NCT03999801Neovascular Age-related Macular Degeneration, Wet Macular Degeneration
AbbVie
Phase 2
865
Arizona, California, Maryland, Massachusetts, Nevada, Pennsylvania, Tennessee, Texas
2019-05-31
Recruiting
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
NCT03808922Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
Ansun Biopharma, Inc.
Phase 3
274
California, Illinois, Iowa, Kansas, Maryland, Massachusetts, Minnesota, Missouri
2019-05-23
Active, closed
Case-Control Study of the Glycotest™ HCC Panel vs AFP for the Detection of Early-stage Hepatocellular Carcinoma
NCT03878550Carcinoma, Hepatocellular, Cirrhosis, Liver
Glycotest, Inc.
Observational
766
California, Florida, Illinois, Maryland, Michigan, Minnesota, New York, Pennsylvania
2019-05-22
Active, closed
Assessment of Medherent Medication Management Device and Adherence Platform
NCT03775044Mental Health Disorder, Medication Adherence
Terrapin Pharmacy
Not applicable
150
Maryland
2019-05-01
Active, closed
Safety and Efficacy of EcoActive on Intestinal Adherent Invasive E. Coli in Patients With Inactive Crohn's Disease
NCT03808103Crohn Disease
DrugBacteriophage preparation
Intralytix, Inc.
Phase 1/2
30
Maryland, New York
2019-05-01
Active, closed
Modified Immune Cells (Autologous CAR T Cells) in Treating Patients with Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
NCT03907527Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Recurrent Fallopian Tube Carcinoma
Precigen, Inc
Phase 1
71
Maryland, Washington
2019-04-30
Active, closed
Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer
NCT03907852Mesothelioma, Mesothelioma, Malignant, Mesothelioma; Pleura, Mesotheliomas Pleural
DrugsIpilimumab·Fludarabine·Nivolumab·Cyclophosphamide
TCR2 Therapeutics
Phase 1/2
57
California, Florida, Illinois, Maryland, New York, North Carolina, Pennsylvania, Tennessee
2019-04-15
Recruiting
An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia
NCT03813407Hyperkalaemia
DrugPumitamig
AstraZeneca
Phase 3
140
Alabama, Georgia, Maryland, Michigan, Missouri, New Jersey, New York, North Carolina
2019-04-02
Active, closed
Avelumab Program Rollover Study
NCT03815643Solid Tumors
DrugAvelumab
EMD Serono Research & Development Institute, Inc.
Phase 3
205
Arizona, Arkansas, California, Connecticut, Florida, Georgia, Maryland, Michigan
2019-03-22
Active, closed
Intra-operative Pancreatoscopy in Patients With IPMN
NCT03729453Intraductal Papillary Mucinous Neoplasm
Boston Scientific Corporation
Observational
100
Colorado, Indiana, Maryland
2019-03-20
Active, closed
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
NCT03845166Neoplasm Malignant, Renal Cell Carcinoma, Hormone Receptor Positive Breast Carcinoma, Metastatic Castration-resistant Prostate Cancer
DrugsZanzalintinib·Avelumab·Tecentriq·Atezolizumab
Exelixis
Phase 1
325
California, Florida, Georgia, Iowa, Kansas, Maine, Maryland, Massachusetts
2019-03-20
Recruiting
Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
NCT03666000Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsAzer-cel·Pirtobrutinib·Aldesleukin·Fludarabine
Imugene Limited
Phase 1
135
Florida, Georgia, Maryland, Massachusetts, Minnesota, New York, Rhode Island, Texas
2019-03-11
Active, closed
Troriluzole in Adult Participants With Spinocerebellar Ataxia
NCT03701399Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3
DrugTroriluzole
Biohaven Pharmaceuticals, Inc.
Phase 3
299
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2019-03-08
Active, closed
Durvalumab and Tremelimumab for Pediatric Malignancies
NCT03837899Pediatric Cancer, Solid Tumor Pediatric, Hematological Malignancies
DrugDurvalumab
AstraZeneca
Phase 1/2
50
Maryland, Massachusetts, New York, Oklahoma, South Carolina
2019-03-07
Active, closed
Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT03836261Chronic Lymphocytic Leukemia
DrugsVenclyxto·Acalabrutinib·Venclexta·Obinutuzumab
Acerta Pharma BV
Phase 3
984
California, Indiana, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, New York
2019-02-25
Active, closed
AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment
NCT03732794Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
AtriCure, Inc.
Not applicable
150
California, District of Columbia, Illinois, Indiana, Maryland, Michigan, Minnesota, Missouri
2019-01-30
Active, closed
Study of NEO-201 in Solid Tumors Expansion Cohorts
NCT03476681Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Cervical Cancer, Uterine Cancer
DrugPembrolizumab
Precision Biologics, Inc
Phase 1/2
121
Maryland, Virginia
2019-01-18
Active, closed
NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy
NCT03589339Radiotherapy, Immunotherapy, Microsatellite Instability-High Solid Malignant Tumour, Metastasis From Malignant Tumor of Liver
DrugsJNJ-90301900·Opdivo·Nivolumab·Keytruda
Nanobiotix
Phase 1
145
California, Florida, Georgia, Illinois, Maryland, Michigan, New Mexico, New York
2019-01-16
Active, closed
Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib
NCT03778229Carcinoma
DrugsSavolitinib·Osimertinib
AstraZeneca
Phase 2
367
California, District of Columbia, Maryland, Massachusetts, Minnesota, New York, Pennsylvania, Washington
2019-01-09
By invitation
A Long-term Observational Study Evaluating Eteplirsen, Golodirsen, or Casimersen in Routine Clinical Practice
NCT06606340Duchenne Muscular Dystrophy
DrugEteplirsen
Sarepta Therapeutics, Inc.
Observational
300
Arkansas, California, District of Columbia, Florida, Iowa, Maryland, Missouri, New York
2019-01-07
Active, closed
Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients
NCT03737643Advanced Ovarian Cancer
DrugsOlaparib·Durvalumab·Paclitaxel·Bevacizumab
AstraZeneca
Phase 3
1,407
California, Florida, Georgia, Illinois, Indiana, Maryland, Michigan, Missouri
2019-01-04
Active, closed
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
NCT03682536Myelodysplastic Syndromes
DrugsEpoetin Alfa·Luspatercept
Celgene
Phase 3
363
California, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Missouri, New Jersey
2019-01-02
Active, closed
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
NCT03742102Triple Negative Breast Neoplasms
DrugsOleclumab·Capivasertib·Dato-DXd·Trastuzumab deruxtecan
AstraZeneca
Phase 1/2
243
Arizona, Maryland, Massachusetts, Michigan, Missouri, Texas, Virginia
2018-12-21
Active, closed
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)
NCT03742895Advanced Solid Neoplasms
DrugOlaparib
Merck Sharp & Dohme LLC
Phase 2
329
Arizona, California, Colorado, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2018-12-12
Active, closed
OCS™ Lung TOP Registry For Donor Lungs for Transplantation
NCT03639025Lung Transplantation
TransMedics
Observational
458
Arizona, California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan
2018-12-10
Active, closed
A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer
NCT03800134Non-Small Cell Lung Cancer
DrugsDurvalumab·Pemetrexed·Gemcitabine·Paclitaxel
AstraZeneca
Phase 3
825
Arizona, California, Colorado, Florida, Illinois, Kansas, Kentucky, Maryland
2018-12-06
Active, closed
Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC
NCT03562637Triple Negative Breast Cancer
OBI Pharma, Inc
Phase 3
575
California, Florida, Illinois, Maryland, Michigan, New Jersey, Pennsylvania, Texas
2018-12-05
Active, closed
Open Label Extension to Assess the Long-Term Safety and Tolerability of ZYN002 in Children and Adolescents With FXS
NCT03802799Fragile X Syndrome
Zynerba Pharmaceuticals, Inc.
Phase 2/3
476
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Maryland
2018-11-09
Active, closed
Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101
NCT03741127Multiple Myeloma
Poseida Therapeutics, Inc.
Phase 1
100
California, Colorado, Illinois, Kansas, Maryland, Michigan, Pennsylvania, Tennessee
2018-10-29
Recruiting
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
NCT03588975Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
Vericel Corporation
Phase 3
45
California, Louisiana, Maryland, Michigan, New York, Ohio, Pennsylvania, Texas
2018-10-24
Active, closed
A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
NCT03539744Multiple Myeloma
DrugsPomalidomide·Venetoclax·Dexamethasone
AbbVie
Phase 3
265
Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts, Michigan
2018-10-22
Active, closed
A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia
NCT03589326Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL)
DrugsPonatinib·Imatinib·Cytarabine·Vincristine
Takeda
Phase 3
245
Alabama, California, Georgia, Indiana, Kansas, Maryland, New Jersey, New York
2018-10-04
Active, closed
Neurotechnology Following Traumatic Brain Injury
NCT03649958Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
Brain State Technologies, LLC
Not applicable
80
Maryland, North Carolina
2018-08-28
By invitation
Advanced Materials Science in XLIF Study
NCT03649490Degenerative Disc Disease, Spondylolisthesis
NuVasive
Observational
300
Connecticut, Florida, Illinois, Kentucky, Maryland, Minnesota, Missouri, North Carolina
2018-08-19
Active, closed
Post Approval Study Investigating Lutonix Drug Coated Balloon for Treatment of Dysfunctional Arteriovenous Fistulae
NCT03506308Arteriovenous Fistula
C. R. Bard
Not applicable
213
Alabama, California, Connecticut, Iowa, Kentucky, Louisiana, Maryland, Massachusetts
2018-08-07
Active, closed
X-linked Hypophosphatemia Disease Monitoring Program
NCT03651505X-linked Hypophosphatemia, Hypophosphatemic Rickets
Ultragenyx Pharmaceutical Inc
Observational
782
Alabama, California, Colorado, Connecticut, Illinois, Indiana, Maryland, Massachusetts
2018-07-16
Recruiting
A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves
NCT05110989Post Operative Pain
AtriCure, Inc.
Observational
5,000
Florida, Maryland, Missouri, New Hampshire, Ohio, Texas
2018-06-29
Active, closed
ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
NCT03499964Urethral Stricture
Urotronic Inc.
Not applicable
127
Arizona, Arkansas, Florida, Iowa, Maryland, Minnesota, Nebraska, New Jersey
2018-06-22
Active, closed
Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy
NCT03755791Hepatocellular Carcinoma
DrugsSorafenib·Cabozantinib·Tecentriq·Atezolizumab
Exelixis
Phase 3
837
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Maryland, Massachusetts
2018-06-10
Active, closed
Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study
NCT03381274Carcinoma, Non-Small-Cell Lung
DrugsOleclumab·Tagrisso·Osimertinib
MedImmune LLC
Phase 1/2
43
California, Colorado, Connecticut, Georgia, Illinois, Maryland, New York, Texas
2018-05-08
Active, closed
Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome
NCT03604198Cushing Syndrome
DrugRelacorilant
Corcept Therapeutics
Phase 2
125
Arizona, California, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland
2018-05-07
Active, closed
Extended Access of Momelotinib in Adults With Myelofibrosis
NCT03441113Neoplasms, Post-polycythemia Vera Myelofibrosis (Post-PV MF), Primary Myelofibrosis (PMF), Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)
GlaxoSmithKline
Phase 2
237
Arizona, California, Colorado, Florida, Georgia, Maryland, Massachusetts, Minnesota
2018-05-03
Active, closed
A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
NCT03401788VHL - Von Hippel-Lindau Syndrome, VHL Gene Mutation, VHL Syndrome, VHL Gene Inactivation
DrugBelzutifan
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
50
Maryland, Massachusetts, Michigan, Pennsylvania, Tennessee, Texas, Utah
2018-05-02
Active, closed
The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration
NCT03348995Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Miach Orthopaedics
Not applicable
250
California, Florida, Georgia, Louisiana, Maryland, Massachusetts, New Jersey, Rhode Island
2018-04-17
Recruiting
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977Metastatic Castration Resistant Prostate Cancer (mCRPC), Small Cell Lung Cancer (SCLC), Follicular Lymphoma (FL)
DrugsMevrometostat·Xtandi·Itraconazole·Enzalutamide
Pfizer
Phase 1
453
Arizona, California, Connecticut, Kansas, Kentucky, Maryland, Massachusetts, Nebraska
2018-04-17
Active, closed
A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
NCT03470922Melanoma
DrugsRelatlimab·Nivolumab
Bristol-Myers Squibb
Phase 2/3
714
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Maryland
2018-04-11
By invitation
Adoptive Cell Therapy Long-term Follow-up (LTFU) Study
NCT03391778Neoplasms
USWM CT, LLC
Phase 1
250
Georgia, Maryland, Michigan, Missouri, New York, North Carolina, Oregon, Pennsylvania
2018-04-09
Active, closed
A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer
NCT03473743Urothelial Carcinoma
DrugsErdafitinib·Cetrelimab·Cisplatin·Carboplatin
Janssen Research & Development, LLC
Phase 1/2
125
Colorado, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania
2018-04-05
Active, closed
A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and Granulocyte Colony Stimulating Factor (G-CSF) as Compared to Placebo and G-CSF for the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Subjects With Multiple Myeloma (MM)
NCT03246529Multiple Myeloma
DrugsMotixafortide·G-Csf
BioLineRx, Ltd.
Phase 3
180
California, Florida, Illinois, Maryland, Minnesota, Missouri, Ohio, Texas
2018-03-23
Active, closed
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations
NCT03390504Urothelial Cancer
DrugsVinflunine·Erdafitinib·Docetaxel·Pembrolizumab
Janssen Research & Development, LLC
Phase 3
629
Alaska, California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Maryland
2018-03-23
Active, closed
Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer
NCT03436485Prostate Cancer Metastatic
DrugsOpevesostat·Midazolam
Orion Corporation, Orion Pharma
Phase 1/2
204
Maryland, Minnesota, Nebraska, New York
2018-03-19
Active, closed
Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC
NCT03257033Locally Advanced Pancreatic Cancer
DrugsAbraxane·Nab-paclitaxel·Gemcitabine
RenovoRx
Phase 3
190
California, District of Columbia, Florida, Iowa, Maryland, Nebraska, New Hampshire, New Jersey
2018-03-12
Active, closed
A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer
NCT03431350Prostatic Neoplasms, Castration-Resistant
DrugsCetrelimab·Abiraterone acetate·Niraparib·Prednisone
Janssen Research & Development, LLC
Phase 2
136
Arizona, Colorado, Florida, Indiana, Maryland, Michigan, New York, Pennsylvania
2018-03-02
Recruiting
The PREDICT Registry:
NCT03448926DCIS, Stage 0 Breast Cancer, Ductal Breast Carcinoma In Situ
PreludeDx
Observational
3,000
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2018-02-27
Active, closed
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
NCT03319485Parkinson Disease
InSightec
Not applicable
92
California, Florida, Maryland, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2018-02-09
Active, closed
First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)
NCT03401385Hormone Receptor Positive Breast Cancer, Triple Negative Breast Cancer, Non-small Cell Lung Cancer
DrugDato-DXd
Daiichi Sankyo Co., Ltd.
Phase 1
890
California, District of Columbia, Georgia, Maryland, Massachusetts, New York, Tennessee, Texas
2018-01-31
Recruiting
Dabrafenib and/or Trametinib Rollover Study
NCT03340506Melanoma, Non Small Cell Lung Cancer, Solid Tumor, Rare Cancers
DrugsDabrafenib·Trametinib
Novartis Pharmaceuticals
Phase 4
100
Arizona, Maryland, Ohio, Texas
2018-01-26
Active, closed
Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN
NCT03386513Blastic Plasmacytoid Dendritic Cell Neoplasm, Myeloproliferative Neoplasm
DrugIMGN632
AbbVie
Phase 1/2
179
Alabama, Arizona, California, Florida, Maryland, Massachusetts, New York, North Carolina
2018-01-02
Recruiting
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
NCT03394365Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant
DrugTabelecleucel
Pierre Fabre Medicament
Phase 3
115
California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Maryland, Massachusetts
2017-12-29
Active, closed
Study Evaluating Safety, Tolerability and Pharmacokinetics (PK) of Tarlatamab in Adults With Small Cell Lung Cancer (SCLC)
NCT03319940Small Cell Lung Carcinoma
DrugsTarlatamab·Pembrolizumab
Amgen
Phase 1
269
California, Connecticut, Florida, Georgia, Illinois, Louisiana, Maryland, Michigan
2017-12-26
Active, closed
Phase II Umbrella Study of Novel Anti-cancer Agents in Participants With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy
NCT03334617Non-Small Cell Lung Cancer
DrugsDanvatirsen·Vistusertib·Cediranib Maleate·Ceralasertib
AstraZeneca
Phase 2
528
California, District of Columbia, Illinois, Maryland, Massachusetts, Missouri, New York, Pennsylvania
2017-12-18
Active, closed
An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia
NCT03424018Achondroplasia
DrugVosoritide
BioMarin Pharmaceutical
Phase 3
119
California, Delaware, Georgia, Illinois, Maryland, Missouri, Ohio, Texas
2017-12-12
Active, closed
Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System
NCT03214601Thoracic Aorta Aneurysm, Aneurysm, Ruptured, Aortic Aneurysm
Bolton Medical
Not applicable
30
California, Florida, Georgia, Maryland, Massachusetts, Missouri, New York, North Carolina
2017-12-04
Active, closed
Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma
NCT03298451Hepatocellular Carcinoma
DrugsSorafenib·Tremelimumab·Durvalumab
AstraZeneca
Phase 3
1,324
California, District of Columbia, Florida, Kansas, Maryland, Michigan, Minnesota, New York
2017-10-11
Active, closed
A Study of AT132 in Young Children With X-Linked Myotubular Myopathy (XLMTM)
NCT03199469X-Linked Myotubular Myopathy
Astellas Gene Therapies
Phase 2/3
27
California, Illinois, Maryland
2017-08-02
Active, closed
JOURNEY II XR Safety and Effectiveness PMCF
NCT03136887Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint
Smith & Nephew, Inc.
Observational
176
California, Florida, Illinois, Maryland, Michigan, Nevada, New Jersey, New York
2017-07-28
Active, closed
Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom
NCT02952508Waldenstrom Macroglobulinemia, Multiple Myeloma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugCLR 131
Cellectar Biosciences, Inc.
Phase 2
120
California, District of Columbia, Florida, Georgia, Illinois, Kansas, Louisiana, Maryland
2017-07-26
Active, closed
Evaluation of the Personal KinetiGraph™ (PKG™) to Improve Insight Into Parkinson's Disease Status
NCT03741920Parkinson Disease
Global Kinetics Corporation
Not applicable
231
California, Florida, Kansas, Maryland, Michigan, New York, Texas
2017-05-17
Active, closed
Study of the Relay Pro® Thoracic Stent-Graft in Subjects With Traumatic Injury of the Descending Thoracic Aorta
NCT03090230Other Specified Injury of Thoracic Aorta
Bolton Medical
Not applicable
50
California, Connecticut, Georgia, Indiana, Iowa, Maryland, Massachusetts, Missouri
2017-04-17
Recruiting
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
NCT03093116Locally Advanced Solid Tumors, Metastatic Solid Tumors
DrugRepotrectinib
Turning Point Therapeutics, Inc.
Phase 1/2
500
California, Colorado, District of Columbia, Florida, Georgia, Illinois, Louisiana, Maryland
2017-03-07
Active, closed
A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy
NCT02993523Acute Myeloid Leukemia (AML)
DrugsAzacitidine·Venetoclax
AbbVie
Phase 3
443
California, Georgia, Illinois, Indiana, Kansas, Kentucky, Maine, Maryland
2017-02-02
Recruiting
A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients
NCT03110822Multiple Myeloma
DrugsDepo-Medrol·Solu-Medrol·Jakavi·Ruxolitinib
Oncotherapeutics
Phase 1
134
California, Florida, Maryland, Washington
2017-02-01
Active, closed
Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
NCT02682511Scleroderma, Diffuse, Scleroderma, Systemic, Scleroderma, Limited, Sclerosis, Progressive Systemic
DrugIfetroban
Cumberland Pharmaceuticals
Phase 2
34
Arizona, California, Florida, Maryland, Massachusetts, Nebraska, New York, Pennsylvania
2017-01
Active, closed
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
NCT03100474Essential Tremor, Parkinson's Disease, Movement Disorders, Neuropathic Pain
InSightec
Observational
500
California, Maryland, Pennsylvania, Virginia, Washington
2016-12
Active, closed
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
NCT02803957Mitral Valve Insufficiency
NeoChord
Not applicable
585
California, District of Columbia, Georgia, Indiana, Maryland, Michigan, New York, Pennsylvania
2016-11-03
Active, closed
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
NCT02932150Chronic Hepatitis B
Gilead Sciences
Phase 2
150
California, Colorado, Indiana, Maryland, Missouri, New York, Ohio, Tennessee
2016-11
Active, closed
A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
NCT02773030Multiple Myeloma
DrugsIberdomide·Darzalex·Velcade·Carfilzomib
Celgene
Phase 1/2
466
Arizona, Arkansas, Georgia, Illinois, Kansas, Maryland, Massachusetts, Michigan
2016-10-14
Active, closed
Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma
NCT02811861Renal Cell Carcinoma
DrugsSunitinib·Everolimus·Lenvatinib·Pembrolizumab
Eisai Inc.
Phase 3
1,069
California, Florida, Illinois, Kansas, Louisiana, Maryland, Massachusetts, Michigan
2016-10-13
Recruiting
MEASuRE: Metreleptin Effectiveness And Safety Registry
NCT02325674Generalised Lipodystrophy, Partial Lipodystrophy
DrugMetreleptin
Chiesi Farmaceutici S.p.A.
Observational
100
Alabama, California, Georgia, Illinois, Kansas, Louisiana, Maryland, Michigan
2016-10-11
Active, closed
Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)
NCT02864992Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC) With MET Exon 14 (METex14) Skipping Alterations or MET Amplification, Lung Adenocarcinoma Stage IIIB/IV
DrugTepotinib
EMD Serono Research & Development Institute, Inc.
Phase 2
337
California, Colorado, Florida, Georgia, Illinois, Indiana, Maryland, Massachusetts
2016-09-13
Active, closed
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 0/1
NCT02777528Aortic Aneurysm, Thoracic, Aorta, Lesion
W.L.Gore & Associates
Not applicable
79
California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana, Maryland
2016-08
Active, closed
BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI)
NCT02805023Chronic Limb-Threatening Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
BioGenCell Ltd.
Phase 1/2
40
California, Connecticut, Maryland
2016-06
Active, closed
Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer
NCT02609776Non-Small-Cell Lung Cancer
DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin
Janssen Research & Development, LLC
Phase 1
751
California, Florida, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri
2016-05-24
Active, closed
A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease
NCT02726386Parkinson's Disease
NeuroDerm Ltd.
Phase 2
214
Arizona, Arkansas, California, Colorado, Florida, Illinois, Iowa, Maryland
2016-05-04
Active, closed
Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options
NCT02650401Solid Tumors, CNS Tumors
DrugEntrectinib
Hoffmann-La Roche
Phase 1/2
69
California, Colorado, Georgia, Illinois, Maryland, Massachusetts, Missouri, New York
2016-05-03
Active, closed
Randomized Controlled Trial of CAN-2409 Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES)
NCT02768363Prostate Cancer
DrugsAglatimagene besadenovec·Valacyclovir
Candel Therapeutics, Inc.
Phase 2
187
Colorado, Illinois, Louisiana, Maryland, Missouri, Nevada, New Jersey, New York
2016-05
Active, closed
A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.
NCT02734004Ovarian, Breast, SCLC, Gastric Cancers
DrugsAvastin·Olaparib·Durvalumab·Bevacizumab
AstraZeneca
Phase 1/2
264
Georgia, Maryland, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania
2016-03-17
Active, closed
Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System
NCT02514525Barrett Esophagus
Pentax Medical
Not applicable
150
California, Florida, Illinois, Maryland, Minnesota, New York, North Carolina, Ohio
2016-03
Active, closed
A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors
NCT02671435Advanced Solid Tumors
DrugsMonalizumab·MFOLFOX6·Cetuximab·Durvalumab
MedImmune LLC
Phase 1/2
383
Alabama, Arizona, California, Colorado, Florida, Illinois, Maryland, Massachusetts
2016-02-22
Active, closed
A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH)
NCT02724228Achondroplasia
DrugVosoritide
BioMarin Pharmaceutical
Phase 2
30
California, Illinois, Maryland, Tennessee, Texas
2016-01-26
Active, closed
Study to Evaluate Imetelstat (GRN163L) in Participants With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
NCT02598661Myelodysplastic Syndromes
DrugImetelstat Sodium
Geron Corporation
Phase 2/3
289
Alabama, Arizona, California, Connecticut, Florida, Indiana, Maryland, Missouri
2016-01-12
Active, closed
Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib Treatment in a Novartis-sponsored Study
NCT02584933ALK Positive Malignancies
DrugCeritinib
Novartis Pharmaceuticals
Phase 4
233
Arkansas, California, Colorado, Maryland, New Jersey
2015-12-11
Active, closed
AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.
NCT02511106Stage IB-IIIA Non-small Cell Lung Carcinoma
DrugOsimertinib
AstraZeneca
Phase 3
682
California, Colorado, Connecticut, Florida, Georgia, Hawaii, Illinois, Maryland
2015-10-21
Active, closed
JOURNEY™ II CR Total Knee System
NCT02440672Osteoarthritis, Knee
Smith & Nephew, Inc.
Observational
170
Arizona, Illinois, Maryland, New York, North Carolina, Ohio
2015-09
Active, closed
Phase 2 Tolerability and Effects of ALK-001 on Stargardt Disease
NCT02402660Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy, Autosomal Recessive Stargardt Disease 1 (ABCA4-related)
DrugALK-001
Alkeus Pharmaceuticals, Inc.
Phase 2
160
Arizona, California, Colorado, Florida, Indiana, Maryland, Michigan, New York
2015-08
Active, closed
Phase III Open Label First Line Therapy Study of MEDI 4736 (Durvalumab) With or Without Tremelimumab Versus SOC in Non Small-Cell Lung Cancer (NSCLC)
NCT02453282Non-Small-Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
1,118
Arizona, California, Connecticut, Florida, Georgia, Hawaii, Maryland, Minnesota
2015-07-21
Active, closed
Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
NCT02503423Solid Tumors, Lymphoma
DrugTolinapant
Taiho Oncology, Inc.
Phase 1/2
253
Alabama, Arizona, California, Connecticut, Georgia, Illinois, Maryland, Massachusetts
2015-07-14
Recruiting
C-Brace Prospective Registry
NCT04640584Pareses, Lower Extremity
Otto Bock Healthcare Products GmbH
Observational
250
Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland
2015-04
By invitation
Registry of Patients With Hypophosphatasia
NCT02306720Hypophosphatasia (HPP)
Alexion Pharmaceuticals, Inc.
Observational
1,571
Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Minnesota, Missouri
2015-01-20
Active, closed
A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)
NCT02293980ccRCC, RCC, Kidney Cancer, Clear Cell Renal Cell Carcinoma
DrugsBelzutifan·Cabozantinib·Opdivo·Nivolumab
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 1
110
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Maryland
2014-11-25
Active, closed
A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer
NCT02107703Breast Neoplasms
DrugsAbemaciclib·Fulvestrant
Eli Lilly and Company
Phase 3
669
Arkansas, California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan
2014-07-22
Active, closed
PERIGON Pivotal Trial
NCT02088554Aortic Stenosis
Medtronic Cardiac Surgery
Not applicable
1,312
California, Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Michigan
2014-05-12
Active, closed
Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy
NCT02633943Transfusion-dependent Beta-Thalassemia
Genetix Biotherapeutics Inc.
Observational
66
California, Illinois, Maryland, New York, Pennsylvania, South Carolina
2014-01
Active, closed
Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy
NCT01874353Platinum Sensitive, BRCA Mutated, Relapsed Ovarian Cancer, Following Complete or Partial Response to Platinum Based Chemotherapy
DrugOlaparib
AstraZeneca
Phase 3
327
Alabama, California, Colorado, Connecticut, Florida, Illinois, Maryland, Massachusetts
2013-09-03
Active, closed
Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma
NCT01843374Unresectable Pleural or Peritoneal Malignant Mesothelioma
DrugTremelimumab
MedImmune LLC
Phase 2
571
Arizona, California, Connecticut, Delaware, Florida, Georgia, Illinois, Maryland
2013-05-17
Active, closed
A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration
NCT01678872Age-Related Macular Degeneration
Oxford BioMedica
Phase 1
18
Iowa, Maryland, Oregon
2012-08
Active, closed
A Study of LY2784544 in Participants With Myeloproliferative Neoplasms
NCT01594723Neoplasms, Hematologic
Eli Lilly and Company
Phase 2
110
Arkansas, California, Connecticut, Florida, Illinois, Indiana, Kansas, Maryland
2012-05-22
Active, closed
Safety and Efficacy Study of the Xoft® Axxent® eBx® IORT System®
NCT01644669Invasive Ductal Carcinoma, Ductal Carcinoma in Situ
Xoft, Inc.
Not applicable
1,200
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, New Hampshire
2012-05-08
Active, closed
Phase 3 Study of ProstAtak® Immunotherapy With Standard Radiation Therapy for Localized Prostate Cancer
NCT01436968Prostate Cancer
DrugsAglatimagene besadenovec·Valacyclovir
Candel Therapeutics, Inc.
Phase 3
711
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Louisiana, Maryland
2011-09
Active, closed
Database Retrieval for the Comprehensive Shoulder
NCT03409718Osteoarthritis of the Shoulder, Avascular Necrosis, Rheumatoid Arthritis, Prior Failed Revision
Zimmer Biomet
Observational
160
Maryland
2011-02-24
Recruiting
Caris Biorepository Research Protocol
NCT01499394Cancer, Early Detection of Cancer, Minimal Residual Disease
Caris Science, Inc.
Observational
100,000
Alabama, Arizona, Arkansas, Florida, Georgia, Illinois, Louisiana, Maryland
2010-11
By invitation
Comprehensive Reverse Shoulder Data Collection
NCT03404778Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects
Zimmer Biomet
Observational
175
Maryland, Michigan, Minnesota, Ohio
2010-03-07
Active, closed
Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.
NCT00099437Breast Cancer
DrugFulvestrant
AstraZeneca
Phase 3
736
Arizona, California, Connecticut, Florida, Illinois, Maryland, Michigan, Missouri
2005-02-13
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 8 October 2026. https://priyalifescience.com/clinical-trials-usa/state/maryland?page=3

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,125 studies in total at the last sync on 08 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,265 of those studies with a site in Maryland.

How many clinical trials are recruiting in Maryland?

645 of the 1,265 studies on this page are recruiting new participants as of the 08 Oct 2026, 03:16 UTC sync. A further 34 have not yet opened recruitment, 545 are active but closed to new participants, and 41 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.