Clinical Trials in Rome, 2026

A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

AbbVie

Phase 3

614

Rome, Brescia

2023-12-19

Active, closed

Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis

NCT06141473Multiple Sclerosis

DrugsCholestyramine·Activated Charcoal·Teriflunomide·Frexalimab

Sanofi

Phase 3

1,655

Cona, Florence, Genoa, Milan, Monza, Naples, Rome, Orbassano

2023-12-13

Recruiting

NCT05995353Crohn's Disease

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

AbbVie

Phase 3

110

Genoa, Naples, Rome, Messina

2023-12-11

Active, closed

Frexalimab in Preservation of Endogenous Insulin Secretion Compared to Placebo in Adults, Adolescents and Children on Top of Insulin Therapy (FABULINUS)

NCT06111586Type 1 Diabetes Mellitus

DrugFrexalimab

Sanofi

Phase 2

197

Torette, Florence, Milan, Naples, Rome, Novara, Varese, Verona

2023-12-11

Active, closed

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

NCT06132958Endometrial Cancer

DrugsAbraxane·Adriamycin·Sacituzumab tirumotecan·Taxol

Merck Sharp & Dohme LLC

Phase 3

710

Bologna, Aviano, Rome, Milan, Rozzano, Candiolo, Bari, Brescia

2023-12-06

Recruiting

Initial Triple Therapy Including Parenteral Treprostinil vs Initial Double Oral Therapy in PAH Group I Patients

NCT06317805Pulmonary Arterial Hypertension

AOP Orphan Pharmaceuticals AG

Phase 4

110

Rome

2023-12-06

Active, closed

A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patients

NCT06514807Essential Thrombocythaemia

DrugBesremi

AOP Orphan Pharmaceuticals AG

Phase 3

117

Bologna, Florence, Rome, Turin

2023-12-04

Recruiting

A Phase 3 Study of Rotigotine in Combination with Rivastigmine in Mild to Moderate Alzheimer's Disease

NCT06702124Alzheimer Disease

I.R.C.C.S. Fondazione Santa Lucia

Phase 3

348

Rome

2023-12-01

Active, closed

A Gene Delivery Study to Evaluate the Safety and Expression of Delandistrogene Moxeparvovec in Participants Under the Age of Four With Duchenne Muscular Dystrophy (DMD)

NCT06128564Duchenne Muscular Dystrophy

Hoffmann-La Roche

Phase 2

Rome

2023-11-29

Active, closed

A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)

NCT06113471NonSegmental Vitiligo

DrugPovorcitinib

Incyte Corporation

Phase 3

450

Brescia, Catania, Milan, Rome, Rozzano

2023-11-27

Recruiting

A Multicenter Multinational Observational Study of Children With Hypochondroplasia

NCT06212947Hypochondroplasia

BioMarin Pharmaceutical

Observational

400

Genoa, Roma, Milan, Rome

2023-11-27

Active, closed

Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents

NCT06120491Metastatic Castration-Sensitive Prostate Cancer

DrugsSaruparib·Zytiga·Xtandi·Abiraterone acetate

AstraZeneca

Phase 3

1,898

Bari, Genoa, Meldola, Milan, Naples, Padova, Rome, Rozzano

2023-11-21

Active, closed

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

NCT06016738Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Exemestane·Anastrozole·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

510

Avellino, Bologna, Meldola, Modena, Reggio Emilia, Udine, Rome, Milan

2023-11-16

Recruiting

CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine

NCT06158698Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure

DrugColchicine

Niguarda Hospital

Phase 3

Naples, Bologna, Trieste, Udine, Rome, Milan, Turin, Ancona

2023-11-14

Active, closed

Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease

NCT06075706Steroid-refractory Acute Graft-versus-host Disease

DrugMC0518

medac GmbH

Phase 2

Bologna, Monza, Pavia, Rome, Turin

2023-11-13

Active, closed

NCT06074588Non-small Cell Lung Cancer (NSCLC)

DrugsTaxotere·Sacituzumab tirumotecan·Pemetrexed·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

556

Meldola, Rome, Milan, Rozzano

2023-11-12

Active, closed

A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2

NCT06072183Stable Nonsegmental Vitiligo, Active Nonsegmental Vitiligo

DrugRitlecitinib

Pfizer

Phase 3

1,571

L’Aquila, Florence, Milan, Roma, Rome, Cagliari

2023-11-08

Active, closed

Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.

NCT05782907Ulcerative Colitis

AbbVie

Phase 3

122

Florence, Rome, Bologna

2023-11-06

By invitation

Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy

NCT06066580Becker Muscular Dystrophy

Edgewise Therapeutics, Inc.

Phase 2

260

Milan, Padova, Rome

2023-11-02

Recruiting

Use of Ctdna in Patients With Gastrointestinal Tract Tumors

NCT06202131Pancreas Cancer, Colon Cancer, Biliary Tract Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Rome

2023-11-01

Active, closed

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

NCT06052059Ulcerative Colitis

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 3

1,109

Monserrato, San Giovanni Rotondo, Rome, Milan, Rozzano, Rho, Naples, Palermo

2023-10-25

Active, closed

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

NCT05949684Myelodysplastic Syndromes

DrugsEpoetin Alfa·Reblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

402

Rome, Milan, Rozzano, Turin, Florence, Bologna, Reggio Calabria, Roma

2023-10-24

Recruiting

Evaluation of Electroencephalographic Biomarkers in Physiological Aging

NCT06824285Aging

IRCCS San Raffaele Roma

Observational

Rome

2023-10-20

Recruiting

Drug Survival of Target Therapies in Atopic Dermatitis

NCT06882148Atopic Dermatitis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

1,167

Rome

2023-10-12

Recruiting

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

NCT06012240Alopecia Areata

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

AbbVie

Phase 3

1,500

Florence, L’Aquila, Rozzano, Naples, Rome, Bologna, Brescia, Catania

2023-10-11

Active, closed

Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

NCT06008756Arteriosclerosis, Hypercholesterolaemia

DrugEnlicitide Decanoate

Merck Sharp & Dohme LLC

Phase 3

14,550

Cona, Rome, Bergamo, Brescia, Milan, Monza, Turin, Palermo

2023-10-09

Active, closed

A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants

NCT06045689Myelodysplastic Syndromes

DrugsReblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

106

Reggio Calabria, Naples, Rome, Pavia, Rozzano (MI), Novara, Turin, Florence

2023-10-05

Recruiting

An 18-month Prospective Natural History Study to Gain Insight Into FSHD2 Pathophysiology and Disease Progression

NCT06079567Facioscapulohumeral Muscular Dystrophy Type 2

Centre Hospitalier Universitaire de Nice

Not applicable

Rome, Milan, Pisa

2023-10-03

Recruiting

Endoscopic Sleeve Gastroplasty With Endomina® for the Treatment of Obesity in Kidney Transplant Candidates

NCT05917795Obesity, Morbid, End Stage Renal Disease, Kidney Transplantation, Endoscopic Sleeve Gastroplasty

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Rome

2023-09-24

Recruiting

FMT in Patients With Recurrent CDI and Ulcerative Colitis: Single Infusion Versus Sequential Approach

NCT06071312Clostridium Difficile, Ulcerative Colitis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase 1/2

Rome

2023-09-23

Recruiting

Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Robot-assisted Surgical Treatment of Genitourinary Cancers

NCT06717711Prostate Carcinoma, Erectile Function, Genito Urinary Cancer

DrugTadalafil

Regina Elena Cancer Institute

Phase 3

158

Rome, Naples

2023-09-15

Active, closed

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

NCT05904886Hepatocellular Carcinoma

DrugsTiragolumab·Tecentriq·Avastin·Atezolizumab

Hoffmann-La Roche

Phase 3

687

Tricase, Bologna, Rome, Genoa, Rozzano, Palermo, Verona

2023-09-14

Active, closed

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

NCT05869955Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis, Rheumatoid Arthritis

DrugsZola-cel·Tocilizumab·Fludarabine·Cyclophosphamide

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 1

270

Rome, Rozzano

2023-09-13

Active, closed

A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome

NCT05946941Sjögren's Syndrome

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

774

Brescia, Milan, Naples, Pisa, Rome, Udine

2023-09-11

Recruiting

NCT05894239Metastatic Breast Cancer

DrugsPhesgo·Inavolisib

Hoffmann-La Roche

Phase 3

230

Meldola, Rome, Milan, Monza, Novara, Palermo, Bagno a Ripoli, Verona

2023-09-08

Recruiting

Rescue of Nephrons With ALE.F02 (RENAL-F02)

NCT06047171Glomerulonephritis Rapidly Progressive

DrugsCyclophosphamid·Rituximab

Alentis Therapeutics AG

Phase 2

Bergamo, Florence, Milan, Rome, Trento

2023-09-07

Recruiting

Safety and Efficacy of Anakinra Treatment for Patients With Post Acute Covid Syndrome

NCT05926505Post-Acute COVID-19 Syndrome, Post-Acute COVID-19, Long COVID

DrugAnakinra

Hellenic Institute for the Study of Sepsis

Phase 2/3

182

Genova, Jesolo, Milan, Modena, Rome

2023-09-06

Recruiting

Micropulsed Laser in Patients With Macular Oedema in Retinal Dystrophies

NCT05976139Macular Edema, Inherited Retinal Dystrophy, Laser Retinopathy

Fondazione G.B. Bietti, IRCCS

Not applicable

Rome

2023-09-06

Recruiting

SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET)

NCT05689619Brain Metastases, Adult, Non Small Cell Lung Cancer, Breast Cancer

A.O.U. Città della Salute e della Scienza

Not applicable

Genova, Messina, Rome, Turin

2023-09-01

Recruiting

Robotic-assisted Versus Conventional Laparoscopic Surgery in Obese Patients With Early Endometrial Cancer

NCT05974995Endometrial Cancer, Endometrial Neoplasms, Obesity, Morbid, Gynecologic Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

566

Rome

2023-09-01

Active, closed

Prospective Evaluation of NfL as a Biomarker in ATTRv

NCT05879874Amyloidosis, Hereditary

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Rome

2023-09-01

Not yet open

National Database of the Virtual Institute of Cerebrovascular Diseases

NCT05925699Cerebrovascular Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

285,600

Rome

2023-09-01

Active, closed

A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

NCT05797610Primary IgA Nephropathy

Hoffmann-La Roche

Phase 3

459

Bari, Naples, Bologna, Rome, Genoa, Pavia, Turin

2023-08-08

Active, closed

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

NCT05843643Systemic Lupus Erythematosus

A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

AbbVie

Phase 3

1,014

Rome, Ancona, Padova, Pisa

2023-07-25

Recruiting

The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema

NCT05890677Lymphedema, Breast Cancer

University Hospital, Basel, Switzerland

Not applicable

280

Rome

2023-07-14

Recruiting

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

NCT05980949Psychosis Associated With Alzheimer's Disease

DrugKarXT

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 3

1,000

Salerno, Rome, Brescia, Milan, Baggiovara, Ponderano (Biella), Florence, Monza

2023-07-11

By invitation

Robotic Surgery in Pulmonary Metastasectomy

NCT06466070Primary Solid Tumors

Scientific Institute San Raffaele

Observational

1,650

Rome, Milan, Rozzano

2023-07-11

Active, closed

Randomized Clinical Trial Aimed at Comparing Unclamped Robotic Partial Nephrectomy With or Without Renorrhaphy

NCT06846112Kidney Cancer

Regina Elena Cancer Institute

Not applicable

248

Rome

2023-07-07

Active, closed

(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma

NCT05907954Uveal Melanoma

DrugDarovasertib

IDEAYA Biosciences

Phase 2

160

Milan, Rome

2023-07-03

Recruiting

Global Research Initiative for Patients Screening on MASH

NCT05651724MASH, MASLD, MASH With Fibrosis, Fibrosis, Liver

Julius Clinical

Observational

10,000

Rome

2023-06-30

Active, closed

Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy

NCT05696717Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy

Theravance Biopharma

Phase 3

102

Bologna, Milan, Rome, Salerno, Terni, Trento, Tricase

2023-06-27

Recruiting

Use of Shockwave M5+/L6 IVL Catheter (Intravascular Lithotripsy) in Hostile and Calcified Iliac Access

NCT05880641Aortic Diseases, Aorto-Iliac Atherosclerosis, Peripheral Arterial Disease

EndoCore Lab s.r.l.

Observational

Ancona, Bologna, Rome, Florence, Perugia, Padova

2023-06-26

Recruiting

Balance Rehabilitation Based on Serious Games

NCT06908564Hip Replacement, Total

IRCCS San Raffaele Roma

Not applicable

Rome, Sulmona

2023-06-23

Recruiting

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358Acute Myocardial Infarction, Coronary Artery Disease

Population Health Research Institute

Not applicable

5,100

Arezzo, Bologna, Ferrara, Grosseto, Reggio Emilia, Rome

2023-06-22

Active, closed

NCT05889182Hidradenitis Suppurativa

Radiotherapy & Total Neoadjuvant Therapy for Recurrent Rectal Cancer in Previously Irradiated Patients, an Italian Association for Radiotherapy and Clinical Oncology (AIRO)-GI Platform: a Multi-centre Prospective Observational Study

AbbVie

Phase 3

1,328

Cona, Florence, L’Aquila, Rome, Brescia, Milan, Modena, Pisa

2023-06-21

Recruiting

NCT05984576Rectal Neoplasm

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Rome

2023-06-21

Recruiting

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

NCT05789082Non-Small Cell Lung Cancer

DrugsDivarasib·Pemetrexed·Cisplatin·Carboplatin

Hoffmann-La Roche

Phase 1/2

320

Naples, Rome, Milan, Orbassano

2023-06-20

Active, closed

Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status

NCT05673187NSCLC Stage IV, KRAS P.G12C

DrugAdagrasib

ETOP IBCSG Partners Foundation

Phase 2

Perugia, Rome, Treviso

2023-06-12

Active, closed

Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)

NCT05733572Optic Pathway Glioma

Benedetto Falsini

Phase 2

Rome

2023-06-12

Active, closed

An Observational Study to Assess Change in Disease Activity and Adverse Events In Adult Participants With Moderate to Severe Active Crohn's Disease (CD)

NCT05841537Crohn's Disease

AbbVie

Observational

1,019

Florence, Rozzano, Milan, Rome, Bari, Bologna, Messina

2023-06-09

Recruiting

A Study of Eptinezumab in Pediatric Participants With Episodic Migraine

NCT05897320Episodic Migraine

DrugEptinezumab

H. Lundbeck A/S

Phase 3

315

Cagliari, Genoa, Milan, Pavia, Pisa, Rome

2023-06-08

Recruiting

NET-TIME: Inflammatory Tumor Microenvironment in Pituitary Neoplasm

NCT07594262Pituitary Tumor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Rome

2023-06-03

Recruiting

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

NCT05714085Heart Failure, Left Ventricular Systolic Dysfunction

DrugVericiguat

Merck Sharp & Dohme LLC

Phase 2/3

342

Genoa, Milan, Turin, Rome, Florence, Padova

2023-05-31

Active, closed

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

NCT05809531C3G, IC-MPGN, C3 Glomerulopathy, C3 Glomerulonephritis

DrugPegcetacoplan

Apellis Pharmaceuticals, Inc.

Phase 3

100

Milan, Ranica, Rome

2023-05-29

Active, closed

ECT STUDY High-grade or Initially Invasive Vulva - GinOnc-ECT Study

NCT06715592Paget Disease of the Vulva, Vulva Cancer

DrugCisplatin

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase 2

Rome

2023-05-23

Recruiting

Concomitant Radiotherapy and New Drugs in Metastatic Breast Cancer

NCT07021911Breast Cancer, Radiotherapy; Complications

Fondazione Policlinico Universitario Campus Bio-Medico

Observational

300

Rome

2023-05-17

Recruiting

A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL

NCT05748171ACUTE LYMPHOBLASTIC LEUKEMIA

DrugInotuzumab Ozogamicin

Pfizer

Phase 2

100

Naples, Genoa, Monza, Rome, Catania, Padova, Pavia, Torino

2023-05-17

Recruiting

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

NCT05442567Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

240

Naples, Bologna, Rome, Monza, Florence, Padova

2023-05-16

Active, closed

A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

NCT05789069Renal Cell Carcinoma, Melanoma, Non Small Cell Lung Cancer, Gastric Cancer

DrugTislelizumab

HiFiBiO Therapeutics

Phase 1

Naples, Rome, Verona

2023-05-09

Active, closed

Digital Twins for Model-driven Non-invasive Electrical Brain Stimulation

NCT06826261Alzheimer Disease

I.R.C.C.S. Fondazione Santa Lucia

Not applicable

Rome

2023-05-04

Active, closed

Phase III Study of AK112 for NSCLC Patients

NCT06396065Non-Squamous Non-small Cell Lung Cancer

DrugsIvonescimab·Pemetrexed·Carboplatin

Summit Therapeutics

Phase 3

420

Milan, Parma, Roma, Rome

2023-05-04

Active, closed

A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have

NCT05831176Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD), Eosinophilic Gastrointestinal Disease (EGID), Eosinophilic Gastroenteritis

DrugDupilumab

Regeneron Pharmaceuticals

Phase 2

Rozzano, Palermo, Bari, Milan, Pisa, Roma, Rome

2023-05-03

Recruiting

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

NCT05711394Episodic Migraine

DrugAtogepant

AbbVie

Phase 3

450

Milan, Rome, Palermo

2023-05-01

Recruiting

Fundus Camera Module for Early Detection of Alzheimer's Disease

NCT06841848Alzheimer Disease

I.R.C.C.S. Fondazione Santa Lucia

Observational

Rome

2023-05-01

Not yet open

RCT KS-SA Versur KS-BA in Diabetic Patients

NCT05847907Dental Implant, Diabetes

Università degli Studi di Sassari

Not applicable

Rome

2023-04-30

Recruiting

AIRFRAME: Artificial Intelligence for Recognition of Fetal bRain AnoMaliEs at Second Trimester Fetal Brain Scan

NCT06675266Fetal Anomalies, Brain Malformation

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

10,000

Rome

2023-04-30

Active, closed

Brain Connectivity Analysis

NCT06823102Neural Injury

IRCCS San Raffaele Roma

Not applicable

Rome

2023-04-28

Active, closed

FOLFIRINOX Versus OncoSil™ in Addition to FOLFIRINOX in Patients With Locally Advanced Pancreatic Adenocarcinoma

NCT05466799Locally Advanced Pancreatic Cancer

OncoSil Medical Limited

Phase 2

Rome, Verona

2023-04-26

Recruiting

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

NCT05786924Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis, BRAF Gene Mutation

DrugsPanitumumab·Folfox·Cetuximab·Nab-paclitaxel

Institut de Recherches Internationales Servier

Phase 1/2

554

Milan, Rome, Rozzano

2023-04-18

Active, closed

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

NCT05645692Urothelial Cancer

DrugsTobemstomig·Tiragolumab·Atezolizumab

Hoffmann-La Roche

Phase 2

204

Bari, Naples, Bologna, Meldola, Rome, Milan, Terni, Padova

2023-04-13

Recruiting

"Cognitive, Motor and Sleep Evaluation in Patients With Ischemic Stroke of Basal Ganglia After Thrombectomy"

NCT05878002Post-stroke Disorders

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

300

Rome

2023-04-12

Recruiting

A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions

NCT05816382Narcolepsy Type 1

DrugTAK-861

Takeda

Phase 2/3

500

Rome, Pozzilli, Bellaria

2023-04-05

Active, closed

A Study Evaluating the Effect of Filgotinib in Participants With Active Axial Spondyloarthritis

NCT05785611Axial Spondyloarthritis

DrugFilgotinib

Alfasigma S.p.A.

Phase 3

495

Bologna, Naples, Palermo, Rome, Udine

2023-04-05

Active, closed

Open Label, Long-term Study Evaluating Safety and Efficacy of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis

NCT05769777Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2

999

Milan, Naples, Rome, Brescia, Vicenza

2023-04-03

Active, closed

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

NCT05794906Biochemically Recurrent Prostate Cancer

DrugDarolutamide

Bayer

Phase 3

985

Foggia, Naples, Bologna, Modena, Reggio Emilia, Aviano, Rome, Genoa

2023-04-03

Recruiting

Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations

NCT06915805Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders

Istituto Superiore di Sanità

Observational

296

Como, Milan, Naples, Rome

2023-04-01

Active, closed

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

NCT05714202Bladder Cancer

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 3

1,135

Acquaviva delle Fonti, Asti, Avellino, Castelfranco Veneto, Milan, Naples, Ravenna, Rome

2023-03-23

Recruiting

Ultrasound and Respiratory Physiological Signals in Lung Diseases

NCT06068647Interstitial Lung Disease, Interstitial Lung Diseases, Interstitial Pneumonia, Chronic Obstructive Pulmonary Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Rome

2023-03-22

Recruiting

The Role of the Free/Pedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)

NCT06287034Larynx Carcinoma

Regina Elena Cancer Institute

Observational

102

Rome

2023-03-21

Recruiting

Prediction of Germline BRCA 1/2 Genes From Healthy Ovaries

NCT05769517BRCA Mutation, Ovarian Cancer, Ultrasound Therapy; Complications

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

6,465

Rome

2023-03-20

Active, closed

Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer

NCT05445778Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer

DrugsMirvetuximab Soravtansine·Bevacizumab

AbbVie

Phase 3

520

Florence, Meldola, Genoa, Rozzano, Milan, Naples, Rome, Mirano

2023-03-15

Recruiting

BPH Global Registry

NCT05543200Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms

Société Internationale d'Urologie

Observational

7,500

Florence, Rome

2023-03-13

Active, closed

Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder

NCT05818943GRIN-related Disorders

DrugRadiprodil

GRIN Therapeutics, Inc.

Phase 1

Rome, Florence

2023-03-07

Recruiting

Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery

NCT06519500Gastro-entero-pancreatic Neoplasms

Regina Elena Cancer Institute

Observational

Rome

2023-03-03

Active, closed

A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer

NCT05654623Advanced Breast Cancer

DrugsVepdegestrant·Fulvestrant

Pfizer

Phase 3

624

Naples, Misterbianco, Bologna, Cona, Rome, Monza, Ancona, Pisa

2023-03-03

Active, closed

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

NCT05669755Cardiovascular Disease

DrugsCagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

7,101

Chieti, Bari, Modena, Parma, Rome, San Donato Milanese (MI), Latina, Pavia

2023-03-01

Active, closed

A Treatment Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice.

NCT05637112Systemic Lupus Erythematosus

AstraZeneca

Observational

551

Naples, Cona, Udine, Rome, Brescia, Milan, Turin, Cagliari

2023-02-27

Active, closed

TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)

NCT05548127Breast Cancer

DrugsVepdegestrant·Abemaciclib

Pfizer

Phase 1/2

Rome, Candiolo

2023-02-23

By invitation

An Extension Study of JR-141 to Evaluate the Long-term Safety and Efficacy in MPS II (Hunter Syndrome) Subjects

NCT05594992Mucopolysaccharidosis II

DrugJR-141

JCR Pharmaceuticals Co., Ltd.

Phase 3

Rome

2023-02-22

Active, closed

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

NCT05676931Advanced Non-Small Cell Lung Cancer

DrugsQuemliclustat·Domvanalimab·Zimberelimab·Docetaxel

Gilead Sciences

Phase 2

400

Meldola, Milan, Padova, Pesaro, Rome

2023-02-21

Active, closed

A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A

NCT05685238Haemophilia A, Haemophilia A With Inhibitors

Novo Nordisk A/S

Phase 3

451

Rome, Florence, Milan, Naples, Roma, Torino

2023-02-13

Recruiting

Superdonor FMT in Patients With Ulcerative Colitis

NCT05739864Active Ulcerative Colitis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase 1/2

Rome

2023-02-13

Active, closed

Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma

NCT05605899High-risk Large B-cell Lymphoma (LBCL)

DrugsAxi-cel·Axicabtagene Ciloleucel·Vincristine·Doxorubicin

Kite, A Gilead Company

Phase 3

300

Bologna, Brescia, Milan, Perugia, Reggio Calabria, Rome, Rozzano

2023-02-10

Active, closed

A Study to Evaluate RO7204239 in Participants With Facioscapulohumeral Muscular Dystrophy

NCT05548556Facioscapulohumeral Muscular Dystrophy (FSHD)

DrugRO7204239

Hoffmann-La Roche

Phase 2

Rome, Milan

2023-02-07

Active, closed

Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)

NCT05609968Carcinoma, Non-Small-Cell Lung

DrugsSacituzumab Govitecan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

614

Rome, Bergamo, Milan, Naples, Florence, Peschiera del Garda, Parma

2023-02-06

Active, closed

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

NCT05686551Huntington Disease

Hoffmann-La Roche

Phase 2

301

Bologna, Rome, Milan

2023-02-03

Recruiting

Rare Embryonal Tumors of the Central Nervous System: International Registry

NCT05711992Embryonal Tumor

Immune Oncology Research Institute

Observational

300

Rome

2023-02-01

Recruiting

Clinical Value and Cost-effectiveness of a Personalized Prevention Program (PPP) in Patients With High Risk Stable CHD

NCT04433052Coronary Heart Disease

Tampere University

Not applicable

12,000

Genova, Milan, Rome, Turin

2023-02-01

Recruiting

Application of Patient Blood Management in the Oncology Patient Affected by Breast Cancer

NCT06883201Breast Cancer

Regina Elena Cancer Institute

Observational

Rome

2023-01-31

Recruiting

Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases

NCT05545007Brain Metastases, Adult

Istituto Clinico Humanitas

Not applicable

146

Brescia, Florence, Rozzano, Milan, Naples, Rome, Terni

2023-01-31

Active, closed

Registry on Percutaneous Electrochemotherapy

NCT05267080Primary Liver Cancer, Secondary Liver Cancer

Cardiovascular and Interventional Radiological Society of Europe

Observational

250

Milan, Rome

2023-01-25

Recruiting

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

NCT05580562H3 K27M, Glioma

DrugDordaviprone

Jazz Pharmaceuticals

Phase 3

510

Bologna, Rome, Milan, Rozzano, Turin, Padova

2023-01-23

Active, closed

A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy

NCT05405361Multifocal Motor Neuropathy (MMN)

DrugEmpasiprubart

argenx

Phase 2

Milan, Pisa, Rome, Rozzano

2023-01-18

Recruiting

Biomarkers of Efficacy and Tolerability of Sacituzumab-Govitecan in the Treatment of Patients With Triple-negative Breast Cancer in the Metastatic Phase: Prospective Multicenter Real-world Study

NCT06240195Breast Cancer

Regina Elena Cancer Institute

Observational

Rome

2023-01-17

Recruiting

Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application

NCT06883214Glioma

Regina Elena Cancer Institute

Observational

Rome

2023-01-17

Active, closed

A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery

NCT05608291Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,564

Ancona, Naples, Meldola, Milan, Bari, Cuneo, Perugia, Rome

2023-01-16

Recruiting

Intracoronary Provocative Test With Acetylcholine in Patients With INOCA and MINOCA

NCT05714319Myocardial Infarction With Non-Obstructive Coronary Artery, Ischemia With Non-Obstructive Coronary Artery

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

600

Rome

2023-01-12

Active, closed

A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)

NCT05617677Systemic Lupus Erythematosus

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

516

Rome, Milan, Pisa, Padova, Brescia, Naples, Verona

2023-01-12

Active, closed

Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

NCT05555732Metastatic Non Small Cell Lung Cancer

DrugsDato-DXd·Pemetrexed·Keytruda·Cisplatin

Daiichi Sankyo

Phase 3

1,170

Candiolo, Lucca, Orbassano, Rome, Udine, Varese, Verona

2023-01-11

Recruiting

Autonomic Involvement in Patient With Cognitive Decline

NCT06292741Dementia, Mild, Dementia of Alzheimer Type

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

120

Rome

2023-01-11

Active, closed

First in Human Study of IMGN151 in Recurrent Gynaecological Cancers

NCT05527184Endometrial Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer

DrugIMGN151

AbbVie

Phase 1

256

Rome, Ancona

2023-01-11

By invitation

European TIF2.0 Registry

NCT07395219Gastro -Oesophagal Reflux, Laryngo-pharyngeal Reflux

Cleveland Clinic London

Observational

500

Rome

2023-01-01

Active, closed

Predictive Tools in Head and Neck Cancer Patients Undergoing Radiotherapy

NCT06806683Head and Neck Cancers, Head and Neck Cancers - Nasopharyngeal, Oral Cavity Cancer, Oropharyngeal Cancers

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

915

Rome

2023-01-01

Recruiting

Superior Cervical Ganglion in Parkinson's Disease

NCT05741151Parkinson Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Rome

2023-01-01

Recruiting

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

NCT05640999Endometrial Cancer

Canadian Cancer Trials Group

Phase 2

393

Florence, Brescia, Lecco, Milan, Rome

2022-12-19

Active, closed

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)

NCT05469737Myelodysplastic Syndromes

DrugAzacitidine

Bristol-Myers Squibb

Phase 2/3

230

Rome, Rozzano, Florence, Bologna

2022-12-14

Recruiting

NCT05706896Dry Age-related Macular Degeneration

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Rome

2022-12-14

Active, closed

CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

NCT05681351Severe Hypertriglyceridemia

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

885

Bergamo, Bologna, Caserta, Milan, Naples, Palmero, Rome

2022-12-13

Active, closed

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

NCT05488314Carcinoma, Non-Small-Cell Lung

DrugsCapmatinib·Amivantamab

Janssen Research & Development, LLC

Phase 1/2

Milan, Naples, Padova, Ravenna, Rome

2022-12-13

Recruiting

A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B

NCT05611801Hemophilia A, Hemophilia B

DrugMarstacimab

Pfizer

Phase 3

100

Genoa, Rozzano, Rome, Parma, Torino

2022-12-09

Active, closed

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

NCT05501886Breast Cancer

DrugsGedatolisib·Alpelisib·Palbociclib·Fulvestrant

Celcuity Inc

Phase 3

701

Milan, Modena, Monza, Parma, Prato, Rome, Udine

2022-12-08

Active, closed

Romiplostim Plus Dexamethasone vs Dexamethasone in Patients With Newly Diagnosed Primary Immune Thrombocytopenia

NCT05325593Primary Immune Thrombocytopenia

DrugsRomiplostim·Dexamethasone

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Phase 3

129

Bologna, Milan, Rome

2022-12-02

Recruiting

MR-proADM as a Early Biomarker for DGF and AR in Kidney and Liver Transplantation

NCT06130046Kidney Transplant; Complications, Liver Transplant; Complications

University of Rome Tor Vergata

Observational

300

Rome

2022-12-01

Recruiting

Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer

NCT05522660Non-Small Cell Lung Cancer, Melanoma

ETOP IBCSG Partners Foundation

Phase 3

180

Naples, Padova, Perugia, Roma, Rome, Siena

2022-11-30

Recruiting

Long Term Trajectories of SMA Patients Receiving or Not Disease-modifying Treatments

NCT05768048Spinal Muscular Atrophy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

500

Genova, Messina, Milan, Rome

2022-11-28

Active, closed

Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis

NCT05588843Colitis Ulcerative

Sanofi

Phase 2

187

Bolzano, Milan, Rozzano, Rome, Catanzaro, Palermo, Pavia

2022-11-25

Active, closed

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Observational

6,000

Chieti, Bari, Catanzaro, Naples, Udine, Rome, Genoa, Bergamo

2022-11-21

Active, closed

Proteogenomic Signatures Analysis In Ovarian Cancer

NCT05953883Ovarian Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Rome

2022-11-17

Recruiting

A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma

NCT05533775Mature B-Cell Non-Hodgkin Lymphoma

DrugsIfosfamide·Glofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

Rome, Turin

2022-11-16

Recruiting

Takotsubo Syndrome and Air Pollution

NCT05731830Takotsubo Syndrome

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

250

Rome

2022-11-15

Recruiting

Metabolomic Evaluation of Psycho-surgical Synergy on Body Image Restoration After Breast Cancer

NCT05616988Psychological

University of Roma La Sapienza

Not applicable

Rome

2022-10-26

Recruiting

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

NCT05253651Colorectal Neoplasms

DrugsTucatinib·Herceptin·Erbitux·Avastin

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

400

Monserrato, Avellino, Rome, Tricase, Brescia, Milan, Naples, Verona

2022-10-24

Active, closed

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05259839Relapsed/Refractory Multiple Myeloma

DrugsEtentamig·Pomalidomide·Daratumumab·Lenalidomide

AbbVie

Phase 1

283

Meldola, Milan, Rome, Bologna

2022-10-20

Recruiting

Gender Differences and Age Related Differences in Emergency Department Admission

NCT05593692Emergencies, Gender, Age Problem

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

15,000

Rome

2022-10-18

Active, closed

A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer

NCT05587296Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes

Bayer

Phase 3

474

Naples, Modena, Rome, Genoa, Milan, Pavia, Turin, Florence

2022-10-14

Active, closed

A Study to Learn About the Safety of BIIB115 Injections and How BIIB115 is Processed in the Bodies of Healthy Adult Male Volunteers and of Pediatric Participants With Spinal Muscular Atrophy Who Previously Took Onasemnogene Abeparvovec

NCT05575011Healthy Volunteer, Muscular Atrophy, Spinal

DrugSalanersen

Biogen

Phase 1

Milan, Rome

2022-10-10

Recruiting

Met Non Small Cell Cancer Registry (MOMENT)

NCT05376891Cancer

EMD Serono Research & Development Institute, Inc.

Observational

700

Misterbianco, Milan, Modena, Naples, Rome, Torino, Varese

2022-10-04

Active, closed

Study of the Adverse Events and Change in Disease State of Pediatric Participants (and Young Adults Between the Ages of 18-25) With Relapsed/Refractory Aggressive Mature B-cell Neoplasms Receiving Subcutaneous (SC) Injections of Epcoritamab

NCT05206357Non-hodgkin Lymphoma

DrugEpcoritamab

Genmab

Phase 1

Florence, Monza, Rome

2022-10-04

Recruiting

Panomic Approach to Immune-Connected Assays in Small Cell Lung Cancer

NCT05797493Small Cell Lung Cancer

DrugAtezolizumab

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Rome

2022-10-04

Recruiting

Management of Aorto-iliac Infection With BioIntegral Surgical No-React® Bovine Pericardial Xenografts

NCT05777681Aortic Diseases

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Rome

2022-10-01

Active, closed

Observational Study in Patients With Cyclin-dependent Kinase-like 5 Deficiency Disorder

NCT05373719Cyclin-Dependent Kinase-Like 5 Deficiency Disorder

Loulou Foundation

Observational

112

Florence, Roma, Rome, Verona

2022-09-30

Recruiting

INSIGHTFUL-FFR Clinical Trial

NCT05437900Coronary Artery Disease, Acute Coronary Syndrome

CoreAalst BV

Phase 4

2,500

Ferrara, La Spezia, Latina, Naples, Rome

2022-09-22

Active, closed

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma

NCT05409066Follicular Lymphoma (FL)

DrugsEpcoritamab·Lenalidomide·Rituximab

Genmab

Phase 3

549

San Giovanni Rotondo, Milan, Turin, Aviano, Rome, Candiolo, Alessandria, Bari

2022-09-20

Recruiting

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT05519085Relapsed or Refractory Multiple Myeloma

DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib

Celgene

Phase 3

810

Meldola, Rome, Catania, Bologna, Pavia

2022-09-20

Active, closed

CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma

NCT05440786Sarcoma, Ewing, Neoplasm Metastasis

DrugsAbemaciclib·Temozolomide·Irinotecan

Eli Lilly and Company

Phase 2

Rome, Bologna

2022-09-20

Recruiting

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

NCT05489211Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer, Ovarian Cancer

DrugsPrednisone/Prednisolone·Volrustomig·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

454

Florence, Genova, Milan, Naples, Rome

2022-09-06

By invitation

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

NCT04905693Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Progressive Pulmonary Fibrosis

DrugTreprostinil

United Therapeutics

Phase 3

1,850

Modena, Rome, Milan, Catania, Siena, Ancona, Forlì, Roma

2022-09-06

Active, closed

Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With Myotonic Dystrophy Type 1

NCT05481879Myotonic Dystrophy Type 1 (DM1)

DrugZeleciment basivarsen

Dyne Therapeutics

Phase 1/2

127

Milan, Rome

2022-09-05

Active, closed

Analysis of the Levels of HLADR+ Extracellular Vesicles in Women With Preeclampsia as a Early Potential Biomarker

NCT06873737Preeclampsia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

300

Rome

2022-09-01

Recruiting

Group CBT in Adolescents With Fragile X Syndrome and in Adolescents With Autism Spectrum Disorder

NCT06677866Fragile X Syndrome (FXS), Autism Spectrum Disorder

Bambino Gesù Hospital and Research Institute

Not applicable

Rome

2022-09-01

Recruiting

Telerehabilitation in People With Parkinson's Disease

NCT05773885Parkinson's Disease

IRCCS San Raffaele Roma

Not applicable

Cassino, Rome

2022-09-01

Active, closed

First-Line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects With Extensive Stage Small Cell Lung Cancer (ES-SCLC)

NCT05361395Extensive Stage Small Cell Lung Cancer

DrugsTarlatamab·Tecentriq·Etoposide·Atezolizumab

Amgen

Phase 1

184

Catanzaro, Monza (MB), Rome

2022-08-24

Recruiting

A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)

NCT05511363Psychosis Associated With Alzheimer's Disease

DrugKarXT

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 3

410

Salerno, Rome, Baggiovara, Ponderano (Biella), Florence, Milan, Monza, Pisa

2022-08-23

Active, closed

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

NCT05492578Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2/3

1,856

Milan, Rozzano, Naples, Rome, Turin, Bologna, Catania, Chieti

2022-08-22

Active, closed

An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice

NCT05494606Ulcerative Colitis

AbbVie

Observational

785

Castellana Grotte, Rozzano, Milan, Naples, Rome, Negrar, Palermo, Pisa

2022-08-15

Active, closed

Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping

NCT05524883Duchenne Muscular Dystrophy (DMD)

DrugZeleciment Rostudirsen

Dyne Therapeutics

Phase 1/2

Rome, Milan

2022-08-12

Active, closed

A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow

NCT05330325SGA, Turner Syndrome, Noonan Syndrome, ISS

DrugsNorditropin·Somapacitan

Novo Nordisk A/S

Phase 3

412

Milan, Florence, Genova, Naples, Roma, Rome

2022-08-10

Active, closed

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

NCT05388669Advanced or Metastatic Non-small Cell Lung Cancer

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 3

418

Bari, Bologna, Milan, Orbassano, Padova, Ravenna, Roma, Rome

2022-08-05

Active, closed

A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

NCT05306340Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Tamoxifen·Exemestane·Everolimus

Genentech, Inc.

Phase 3

373

Modena, Rome, Genoa, Milan, Torrette Di Ancona, Verona

2022-08-03

Recruiting

A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

NCT05410145KRAS P.G12C

DrugsD3S-001·Cetuximab·Pemetrexed·Cisplatin

D3 Bio (Wuxi) Co., Ltd

Phase 1/2

442

Candiolo, Milan, Naples, Rome, Siena

2022-08-03

Recruiting

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

NCT05477563Beta-Thalassemia, Thalassemia, Hematologic Diseases, Genetic Diseases, Inborn

DrugExa-cel

Vertex Pharmaceuticals Incorporated

Phase 3

Rome

2022-08-02

Active, closed

A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

NCT05133531Paroxysmal Nocturnal Hemoglobinuria

DrugsSoliris·Ultomiris·Cemdisiran·Pozelimab

Regeneron Pharmaceuticals

Phase 3

202

Florence, Rome, Turin

2022-08-01

Recruiting

Therapeutic Effect of Surgical Debulking of Metastatic Lymph Nodes in Cervical Cancer Stage IIICr

NCT05421650Cervical Cancer

CHA University

Not applicable

240

Rome

2022-08-01

Active, closed

Noninterventional Study Evaluating Parkinson's Disease Diary Use

NCT05363046Parkinson's Disease

BlueRock Therapeutics

Observational

194

Ancona, Padova, Rome, Salerno

2022-07-29

Active, closed

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

NCT05296798Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Phesgo·Pertuzumab·Trastuzumab

Hoffmann-La Roche

Phase 3

922

Naples, Reggio Emilia, Rimini, Rome, Brescia, Milan, Rozzano, Misterbianco (CT)

2022-07-18

Active, closed

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)

NCT05406401Lymphoma, Large B-Cell, Diffuse (DLBCL)

DrugsRituximab Biosimilar·Zilovertamab vedotin·Truxima·Adriamycin

Merck Sharp & Dohme LLC

Phase 2

Rome, Milan, Palermo, Florence, Alessandria

2022-07-14

Active, closed

Study of INCB123667 in Subjects With Advanced Solid Tumors

NCT05238922Solid Tumors

DrugsRibociclib·Palbociclib·Olaparib·Fulvestrant

Incyte Corporation

Phase 1

291

Milan, Naples, Rome, Rozzano, Verona

2022-07-05

Recruiting

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

NCT05203172Solid Tumors

DrugsVemurafenib·Binimetinib·Encorafenib·Zirabev

Pfizer

Phase 4

210

Bari, Perugia, Rome, Candiolo, Padova, Bologna, Milan, Naples

2022-07-05

Recruiting

Post COVID-19 Condition

NCT05531773COVID-19

Euresist Network GEIE

Observational

2,300

Rome, Milan

2022-07-01

Recruiting

Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA

NCT05990348Respiratory Failure, Weaning Failure

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Rome

2022-07-01

Recruiting

Early Visual Functions in Patients at Risk of Developing Cerebral Visual Impairment. A Pilot Study

NCT05865093Visual Impairment

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

700

Rome

2022-07-01

Active, closed

Relacorilant in Combination With Nab-Paclitaxel in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer

NCT05257408Ovarian Neoplasm, Fallopian Tube Neoplasms, Peritoneal Neoplasms

DrugsNab-paclitaxel /m^2·Relacorilant

Corcept Therapeutics

Phase 3

381

Catania, Legnago, Milan, Pavia, Roma, Rome, Torino, Treviso

2022-06-29

Active, closed

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT04975997Multiple Myeloma

DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone

Celgene

Phase 3

939

Rome, Bologna, Catania, Genova, Milan, Novara, Pavia, Pisa

2022-06-23

Active, closed

SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM

NCT05405166Plasma Cell Myeloma Recurrent

DrugsParacetamol / Acetaminophen·Montelukast·Diphenhydramine·Isatuximab

Sanofi

Phase 3

531

Torette, Meldola, Rome, Bologna, Brescia, Pavia

2022-06-23

Active, closed

A Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants With Severe or Moderate Hemophilia A Without Factor VIII Inhibitors on Emicizumab Prophylaxis

NCT05181618Severe Hemophilia A, Moderate Hemophilia A

DrugEmicizumab

Hoffmann-La Roche

Phase 4

136

Naples, Rome, Milan, Florence

2022-06-20

Recruiting

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

NCT05384626Locally Advanced Solid Tumor, Metastatic Solid Tumor

DrugsNeladalkib·Repaglinide·Itraconazole·Midazolam

Nuvalent Inc.

Phase 1/2

840

Ancona, Bari, Milan, Padova, Ravenna, Rome

2022-06-09

Active, closed

BIVV020 (SAR445088) in Prevention and Treatment of Antibody-mediated Rejection (AMR)

NCT05156710Transplant Rejection

DrugsAntithymocyte globulin·Riliprubart·Immunoglobulin·IVIG

Sanofi

Phase 2

Bologna, Rome, Brescia, Milan

2022-06-09

Recruiting

A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)

NCT05813678Phenylketonuria (PKU)

DrugPegvaliase

BioMarin Pharmaceutical

Observational

450

Bologna, Florence, Milan, Naples, Padova, Palermo, Rome

2022-06-06

Active, closed

A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy

NCT05115110Spinal Muscular Atrophy (SMA)

DrugsRO7204239·Risdiplam

Hoffmann-La Roche

Phase 2/3

Rome, Genoa, Milan, Ancona

2022-06-02

Active, closed

Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)

NCT05186974Non-small Cell Lung Cancer

DrugsSacituzumab Govitecan·Paraplatin·Keytruda·Cisplatin

Gilead Sciences

Phase 2

193

Brescia, Catania, Parma, Rome, Rozzano

2022-05-30

Active, closed

An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration

NCT05300724Age-Related Macular Degeneration

Genentech, Inc.

Observational

400

Udine, Rome, Milan

2022-05-27

Active, closed

A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)

NCT05123703Relapsing-remitting Multiple Sclerosis

DrugsFingolimod·Ocrelizumab

Hoffmann-La Roche

Phase 3

188

Chieti, Bari, Rome, Milan, Catania

2022-05-19

Recruiting

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

NCT05039619Lupus Nephritis

DrugsAcetaminophen/paracetamol·Diphenhydramine hydrochloride·Mycophenolate Mofetil·Methylprednisolone

Hoffmann-La Roche

Phase 2

Rome, Genoa, Milan

2022-05-12

Recruiting

To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva

NCT05090891Fibrodysplasia Ossificans Progressiva (FOP)

Incyte Corporation

Phase 2

Rome

2022-05-05

Active, closed

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

NCT05269004Multiple Sclerosis

A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)

Hoffmann-La Roche

Phase 3

1,300

Gallarate, Ponderano, Rome, Genoa, Milan, Montichiari, Orbassano, Cefalù

2022-05-03

Active, closed

Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)

NCT05356195Beta-Thalassemia, Thalassemia, Genetic Diseases, Inborn, Hematologic Diseases

DrugExa-cel

Vertex Pharmaceuticals Incorporated

Phase 3

Rome

2022-05-03

Active, closed

Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)

NCT05329649Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hemoglobinopathies

DrugExa-cel

Vertex Pharmaceuticals Incorporated

Phase 3

Rome

2022-05-02

Recruiting

Versatile Ampification Single-Molecule Detection in Liquid Biopsy

NCT05940311Liquid Biopsy, Melanoma (Skin), Melanoma Stage III, Melanoma Stage IV

Regina Elena Cancer Institute

Observational

Rome

2022-04-27

Active, closed

NCT05288166Prostatic Neoplasms, Neoplasm Metastasis, Urogenital Neoplasms, Physiological Effects of Drugs

DrugsAbiraterone·Abemaciclib·Prednisolone·Prednisone

Eli Lilly and Company

Phase 3

925

Meldola, Rome, Milan, Castelfranco Veneto, Terni, Trento

2022-04-14

Recruiting

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

NCT05131022Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)

DrugBexobrutideg

Nurix Therapeutics, Inc.

Phase 1

572

Bologna, Brescia, Milan, Rome

2022-04-13

Recruiting

Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

NCT04829175Stress Urinary Incontinence, Pelvic Organ Prolapse

Ethicon, Inc.

Observational

1,000

Rome

2022-04-11

Recruiting

Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus

NCT05918510Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site, High-risk Human Papillomavirus Infection, Liquid Biopsy

Regina Elena Cancer Institute

Observational

142

Rome

2022-04-04

Recruiting

A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

NCT04928846Non Small Cell Lung Cancer, c-MET

DrugsTelisotuzumab vedotin·Docetaxel

AbbVie

Phase 3

768

Misterbianco, Milan, Naples, Rome, Bari, Cremona, Messina, Perugia

2022-03-25

Active, closed

Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant

NCT05317416Multiple Myeloma

DrugsElranatamab·Lenalidomide

Pfizer

Phase 3

854

Meldola, Rome, Milan, Catania, Siena, Ancona, Bologna, Roma

2022-03-25

Recruiting

i-NEED: NEw migrainE Drugs Database

NCT07103694Episodic Migraine, Chronic Migraine, Medication Overuse Headache

IRCCS San Raffaele Roma

Observational

2,641

Milan, Rome

2022-03-24

Active, closed

Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)

NCT05224141Small Cell Lung Carcinoma

DrugsPembrolizumab/Vibostolimab·Tecentriq·Paraplatin·Etoposide

Merck Sharp & Dohme LLC

Phase 3

460

Naples, Milan, Rozzano, Rome

2022-03-24

Recruiting

Prognosis in Adult Patients With Congenital Heart Disease

NCT06723704Adult Congenital Heart Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

450

Rome

2022-03-21

Active, closed

COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events

NCT05333068Multivessel Coronary Artery Disease, Ischemia, Vulnerable Plaque, Coronary Artery Disease

Diagram B.V.

Not applicable

1,223

Milan, Rome

2022-03-16

Active, closed

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

NCT05239728Carcinoma, Renal Cell

DrugsBelzutifan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

1,800

Bari, Meldola, Rome, Milan, Orbassano, Florence, Arezzo, Bologna

2022-03-15

Active, closed

Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations

NCT05215340Metastatic Non Small Cell Lung Cancer

DrugsDato-DXd·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

740

Bari, Chieti, Lucca, Milan, Naples, Perugia, Rome, Varese

2022-03-04

Recruiting

Helmet NIV vs. CPAP vs. High-flow Nasal Oxygen in Hypoxemic Respiratory Failure

NCT05089695Respiratory Failure, Hypoxemic Respiratory Failure

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

1,200

Rome

2022-03-01

Recruiting

Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

NCT05156398Migraine

DrugRimegepant

Pfizer

Phase 3

640

Bari, Brescia, Latina, Rome, Milan

2022-02-28

Recruiting

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

NCT04988555Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute, Multiple Myeloma, Myelodysplastic Syndromes

DrugsAzoles·Gilteritinib·Azacitidine·Venetoclax

Sumitomo Pharma America, Inc.

Phase 1/2

606

Bologna, Busto Arsizio, Genoa, Meldola, Padua, Perugia, Ravenna, Rome

2022-02-28

Recruiting

Hospitalised COVID-19 Patients Cohort Study in the EuCARE Project

NCT05463380COVID-19

Euresist Network GEIE

Observational

22,000

Milan, Rome

2022-02-23

Active, closed

Setrusumab vs Placebo for Osteogenesis Imperfecta

NCT05125809Osteogenesis Imperfecta

DrugSetrusumab

Ultragenyx Pharmaceutical Inc

Phase 2/3

183

Bologna, Rome, Verona

2022-02-21

Recruiting

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

NCT05128825High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

DrugAzenosertib

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 2

310

Naples, Modena, Aviano, Rome, Milan, Verona, Bologna

2022-02-17

Recruiting

Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)

NCT05263206Pruritus

DrugsFexofenadine·Dupilumab

Sanofi

Phase 3

284

Cona, Florence, Milan, Rozzano, Naples, Rome, Ancona

2022-02-15

Active, closed

A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II (STARLIGHT)

NCT04573023Mucopolysaccharidosis II

DrugsIdursulfase·JR-141

JCR Pharmaceuticals Co., Ltd.

Phase 3

Rome

2022-02-14

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)

NCT05031780Sickle Cell Disease

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 2/3

286

Naples, Modena, Rome, Genoa, Palermo

2022-02-11

Recruiting

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

NCT04779320Crohn's Disease (CD)

DrugVedolizumab

Takeda

Phase 3

120

Naples, Bologna, Rome, Monza, Padova

2022-02-10

Active, closed

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)

NCT05173987Endometrial Neoplasms

DrugsTaxotere·Paraplatin·Taxol·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

280

Naples, Bologna, Meldola, Milan, Turin, Rome, Florence, Vicenza

2022-02-03

Active, closed

External Hypofractionated Radiotherapy With Simultaneous Integrated Boost in Early Breast Cancer Patients

NCT06224244Breast Neoplasms, Breast Cancer

Regina Elena Cancer Institute

Phase 2

180

Rome

2022-02-01

Recruiting

BIOmarkers and PLAtelet Function Assessment in Myocardial Ischemia and Non Obstructive Coronary Arteries Study

NCT05714241Ischemia With no Obstructive Coronary Artery Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

200

Rome

2022-02-01

Active, closed

Multimodal Morpho-functional Study in Glaucoma Patients-Citicoline Oral Solution

NCT05315206Primary Open Angle Glaucoma

Fondazione G.B. Bietti, IRCCS

Not applicable

Roma, Rome

2022-01-25

Active, closed

Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN

NCT05309668Neurofibromatosis Type 1

DrugSelumetinib

AstraZeneca

Phase 1/2

Milan, Rome

2022-01-21

Active, closed

ADH1 and ADH2 Disease Monitoring Study (DMS)

NCT05227287Autosomal Dominant Hypocalcemia

Calcilytix Therapeutics, Inc., a BridgeBio company

Observational

Milan, Rome

2022-01-20

Active, closed

Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

NCT05407636AMD, nAMD, Wet Age-related Macular Degeneration, wAMD

DrugsEylea·Aflibercept

AbbVie

Phase 3

735

Cona, Milan, Naples, Rome, Negrar, Bari, Chieti, Udine

2022-01-13

Recruiting

Short- and Long-term Behavioral, Cognitive and Motor Outcomes of Frameless Deep Brain Stimulation in Patients With Parkinson's Disease: a Prospective Observational Study

NCT05752656Parkinson Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Rome

2022-01-12

Active, closed

An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.

NCT05217628Trigeminal Neuralgia

Noema Pharma AG

Phase 2/3

166

Rome, Florence, Milan

2022-01-11

Recruiting

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

NCT05118789Locally Advanced Solid Tumor, Metastatic Solid Tumor

Nuvalent Inc.

Phase 1/2

359

Ancona, Bari, Milan, Padova, Ravenna, Rome

2022-01-04

Recruiting

Mutational Oncology in Clinical Practice

NCT06020625Genome Instability, Genetic Predisposition to Disease, Gene Rearrangement

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

20,000

Rome

2022-01-01

Recruiting

ALTo endogrAft Italian Registry

NCT05234892Abdominal Aortic Aneurysm

Gianmarco de Donato

Observational

300

Rome, Siena

2022-01-01

Active, closed

Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE

NCT04919226Neuroendocrine Tumors

DrugsFOLFOX (Folinic acid·Everolimus·Fluorouracil·Oxaliplatin

ITM Solucin GmbH

Phase 3

259

Messina, Milan, Rome

2021-12-21

Active, closed

Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer

NCT04905069Prostate Cancer

Boston Scientific Corporation

Not applicable

500

Parma, Rome, Verona

2021-12-21

Recruiting

Association of Thoraco-mediastinal Radiotherapy With Maintenance Immunotherapy Treatment With Atezolizumab

NCT06771518Small Cell Lung Cancer

Regina Elena Cancer Institute

Phase 2

Rome

2021-12-15

By invitation

Long-Term Follow-Up Study After Gene-Modified Cell Treatment in Kite Studies

NCT05041309Solid and Hematological Malignancies, Autoimmune Diseases

DrugsKITE-197·SPRX002·KITE-753·Tecartus

Kite, A Gilead Company

Observational

1,500

Milan, Rome

2021-12-15

Active, closed

A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

NCT05070858Generalized Myasthenia Gravis

DrugsCemdisiran·Pozelimab

Regeneron Pharmaceuticals

Phase 3

288

Rome, Milan, Pisa, Bergamo, Roma

2021-12-14

Recruiting

Efficacy and Safety of ESD for the Treatment of Superficial Gastric Neoplasms

NCT05930860Gastric Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

200

Rome

2021-12-12

Active, closed

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

NCT05152147Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma

DrugsZanidatamab·Herceptin·Trastuzumab·Adrucil

Jazz Pharmaceuticals

Phase 3

920

Bologna, Candiolo, Genova, Meldola, Milan, Modena, Reggio Emilia, Rome

2021-12-02

Recruiting

A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

NCT05164172Migraine

DrugEptinezumab

H. Lundbeck A/S

Phase 3

600

Rome, Genoa, Milan, Cagliari, Florence, Pisa, Pavia

2021-12-01

Active, closed

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)

NCT05060016Relapsed/Refractory Small Cell Lung Cancer

DrugTarlatamab

Amgen

Phase 2

222

Parma, Rome, Varese

2021-12-01

Active, closed

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)

NCT05130450Familial Chylomicronemia Syndrome

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

Naples, Palermo, Rome

2021-11-18

Active, closed

Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus Erythematosus

NCT05039840Systemic Lupus Erythematosus

DrugFrexalimab

Sanofi

Phase 2

109

Milan, Rome

2021-11-10

Recruiting

BACTERIUM: Study for a Machine-learning-based Model to Predict Bloodstream Infections

NCT05876598Infection, Bloodstream

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

5,000

Rome

2021-11-03

Active, closed

A Study of the Safety and Tolerability in Participants With PIK3CA-related Overgrowth Spectrum or Proteus Syndrome Who Are Being Treated With Miransertib (MK-7075) in Other Studies (MK-7075-006)

NCT04980872PIK3CA-Related Overgrowth Spectrum (PROS)/Proteus Syndrome (PS)

Merck Sharp & Dohme LLC

Phase 2

Rome

2021-11-02

Active, closed

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus

NCT04963296Systemic Lupus Erythematosus

DrugsAcetaminophen/paracetamol·Diphenhydramine hydrochloride·Methylprednisolone·Obinutuzumab

Hoffmann-La Roche

Phase 3

303

Rome, Milan, Pisa, Cona (Ferrara), Padova

2021-10-26

Recruiting

Natural History and Prognosis of Pediatric Epilepsies With Different Etiology

NCT07588971Pediatric Epilepsies

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

2,300

Rome

2021-10-26

Recruiting

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

NCT04929223Metastatic Colorectal Cancer

DrugsDivarasib·Tiragolumab·Inavolisib·Tecentriq

Hoffmann-La Roche

Phase 1

542

Naples, Meldola, Rome, Milan, Padova

2021-10-22

Active, closed

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

NCT04861259Atypical Hemolytic Uremic Syndrome

DrugCrovalimab

Hoffmann-La Roche

Phase 3

Rome, Genoa

2021-10-22

Active, closed

Study of Vimseltinib for Tenosynovial Giant Cell Tumor

NCT05059262Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse

DrugVimseltinib

Deciphera Pharmaceuticals, LLC

Phase 3

123

Bologna, Milan, Naples, Padua, Rome

2021-10-14

Active, closed

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

NCT04931342Ovarian Cancer

DrugsCobimetinib·Ipatasertib·Giredestrant·Inavolisib

Hoffmann-La Roche

Phase 2

176

Bari, Naples, Rome, Milan

2021-10-07

Active, closed

A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer

NCT04975308Breast Neoplasms, Neoplasm Metastasis

DrugsImlunestrant·Exemestane·Abemaciclib·Fulvestrant

Eli Lilly and Company

Phase 3

874

Naples, Aviano, Rome, Genoa, Florence, Padova

2021-10-04

Active, closed

A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases

NCT04603807Carcinoma, Non-Small-Cell Lung

DrugsEntrectinib·Crizotinib

Hoffmann-La Roche

Phase 3

217

Rome, Genoa, Orbassano, Padova

2021-09-30

Recruiting

International Rare And Severe Psoriasis Expert Network

NCT04359394Pustular Psoriasis (PP)

University Hospital, Basel, Switzerland

Observational

180

Rome

2021-09-22

Active, closed

Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033)

NCT04776252HIV-1 Infection

DrugDOR/ISL

Merck Sharp & Dohme LLC

Phase 3

2,000

Rome, Milan, Pavia

2021-09-15

Active, closed

Ovarian Tumor Organotypic Slices Cultures for functionAl Drug Testing and Therapy Response Prediction

NCT06065358Ovarian Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Rome

2021-09-13

Recruiting

Post Market Clinical Follow-up Study on TVT ABBREVO® Continence System

NCT04829357Stress Urinary Incontinence

Ethicon, Inc.

Observational

195

Rome

2021-09-09

Active, closed

Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome

NCT05035030Alagille Syndrome

DrugOdevixibat

Albireo, an Ipsen Company

Phase 3

Florence, Padova, Rome

2021-09-03

Active, closed

A Study of AL102 in Patients With Progressing Desmoid Tumors

NCT04871282Desmoid, Desmoid Tumor

Immunome, Inc.

Phase 2/3

198

Bologna, Milan, Rome

2021-09-01

Active, closed

Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)

NCT04959448Chronic Rhinosinusitis With Nasal Polyposis

DrugDupilumab

Regeneron Pharmaceuticals

Observational

717

Rozzano, Catania, Pisa, Siena, Padova, Catanzaro, Genova, Rome

2021-08-12

Recruiting

Predictive Factors for Massive Transfusion During Liver Transplantation

NCT05763446Liver Transplant; Complications

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

400

Rome

2021-07-31

Recruiting

The GUARDIAN Trial

NCT04884802Blood Pressure

The University of Texas Health Science Center, Houston

Not applicable

6,254

Rome

2021-07-25

Active, closed

A Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Velodrome)

NCT04657289Neovascular Age-related Macular Degeneration (nAMD)

DrugRanibizumab

Hoffmann-La Roche

Phase 3

451

Chieti, Bari, Trieste, Rome, Milan, Torrette - Ancona, Florence, Perugia

2021-07-14

Active, closed

Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.

NCT05018286Short Bowel Syndrome

DrugApraglutide

VectivBio AG

Phase 3

158

Bologna, Rome, Turin

2021-07-13

Recruiting

A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

NCT04965675Chronic Migraine in Children

DrugEptinezumab

H. Lundbeck A/S

Phase 3

285

Pavia, Rome, Milan, Cagliari, Genoa

2021-06-30

Active, closed

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

NCT04895358Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol

Merck Sharp & Dohme LLC

Phase 3

342

Rome, Milan, Monza, Rozzano, Bari, Catania, Naples, Padova

2021-06-18

Active, closed

A Study of Guselkumab in Participants With Active Psoriatic Arthritis

NCT04882098Arthritis, Psoriatic

DrugGuselkumab

Janssen Research & Development, LLC

Phase 3

1,054

Catania, Milan, Naples, Palermo, Rome, Torino, Verona

2021-06-17

Recruiting

Riluzole in Patients With Spinocerebellar Ataxia Type 7

NCT03660917SCA7

DrugRiluzole

S. Andrea Hospital

Phase 2/3

Rome

2021-06-01

Recruiting

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

NCT04844606Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease

DrugMirikizumab

Eli Lilly and Company

Phase 3

150

Bergamo, Bologna, Florence, Milan, Roma, Rome

2021-05-26

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

NCT07218029Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 3

815

Monza, Milan, Rome, Naples

2021-05-12

Active, closed

An Observational Study to Evaluate the Real-World Clinical Management and Outcomes of ALK-Positive Advanced NSCLC Participants Treated With Alectinib

NCT04764188NSCLC

DrugAlectinib

Hoffmann-La Roche

Observational

800

Taranto, Reggio Calabria, Meldola, Rome, Genoa, Brescia, Cremona, Novara

2021-05-10

Active, closed

A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease

NCT04777331Parkinsons Disease

DrugPrasinezumab

Hoffmann-La Roche

Phase 2

586

Naples, Salerno, Bologna, Rome, Genoa, Brescia, Milan, Pozzilli (IS)

2021-05-05

Recruiting

Evaluation of Different Perimetric Grids to Detect Central Visual Field Defect in Glaucoma Patients With Reduce Ganglion Cell Layer Thickness Measured by Spectral Domain OCT.

NCT06227611Glaucoma

Fondazione G.B. Bietti, IRCCS

Observational

Rome

2021-05-04

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

NCT04873362Breast Cancer

DrugsTrastuzumab emtansine·Herceptin·Tecentriq·Trastuzumab

Hoffmann-La Roche

Phase 3

1,188

Avellino, Naples, Modena, Aviano, Rome, Brescia, Milan, Livorno

2021-05-04

Active, closed

Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).

NCT04372953Lung Injury, Preterm Birth

Murdoch Childrens Research Institute

Not applicable

906

Monza, Varese, Florence, Milan, Rome

2021-05-04

Active, closed

A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy

NCT04660344Muscle-invasive Bladder Cancer

DrugsTecentriq·Atezolizumab

Hoffmann-La Roche

Phase 3

761

Naples, Bologna, Meldola, Rome, Genoa, Milan, Orbassano, Arezzo

2021-05-03

Recruiting

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

NCT04752774Spasticity

DrugsDysport·Corabotase

Ipsen

Phase 1/2

240

Brescia, Naples, Rome, Verona

2021-04-29

Recruiting

Neurodevelopmental Outcome in Newborn With Hypoxic-ischemic Encephalopathy Treated With Therapeutic Hypothermia

NCT05767476Encephalopathy, Hypoxic Ischemic

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Rome

2021-04-28

Active, closed

A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab

NCT04770896Unresectable Hepatocellular Carcinoma

DrugsSorafenib·Tecentriq·Lenvatinib·Atezolizumab

Hoffmann-La Roche

Phase 3

557

Naples, Bologna, Rome, Milan, Turin, Palermo, Florence, Pisa

2021-04-26

Recruiting

RESTORE - Study of AGN1 LOEP to Prevent Secondary Hip Fractures

NCT04796350Fragility Fracture, Hip Fractures, Osteoporosis

AgNovos Healthcare, LLC

Not applicable

2,400

Florence, Milan, Rome, Torino

2021-04-24

Recruiting

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

NCT04752722Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Non-muscle Invasive Bladder Cancer

DrugPhase 2

enGene, Inc.

Phase 1/2

350

Milan, Naples, Rome, Torino

2021-04-22

Active, closed

Observational Clinical Investigation of Arthrosamid in Knee Osteoarthritis

NCT05057559Knee Osteoarthritis

Contura

Observational

201

Rome

2021-04-21

Active, closed

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

NCT04736706Carcinoma, Renal Cell

DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda

Merck Sharp & Dohme LLC

Phase 3

1,688

Modena, Rome, Bari, Milan, Naples, Terni

2021-04-14

Active, closed

Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

NCT04763200Left Ventricular Dysfunction, Coronary Artery Disease

Abiomed Inc.

Not applicable

1,252

Rome, San Donato Milanese

2021-04-13

Recruiting

Twin Pregnancy: a Challenge for Patients, Families and Health Professionals

NCT05761769Twin Pregnancy With Antenatal Problem, Twin Diseases, Twin Placenta

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

200

Rome

2021-04-09

Active, closed

Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

NCT04586023Relapsing Multiple Sclerosis

DrugsFenebrutinib·Teriflunomide

Hoffmann-La Roche

Phase 3

751

Chieti, Bari, Naples, Rome, Genoa, Milan, Montichiari, Pavia

2021-03-24

Active, closed

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

NCT04586010Relapsing Multiple Sclerosis

DrugsFenebrutinib·Teriflunomide

Hoffmann-La Roche

Phase 3

746

Foggia, Naples, Parma, Rome, Bergamo, Milan, Mondovì (CN), Catania

2021-03-17

Recruiting

Subthreshold Laser Treatment for Reticular Pseudodrusen Secondary to Age-related Macular Degeneration

NCT04847635Macular Degeneration, Senile, Laser Burn of Retina, Macular Degeneration Intermediate, Macular Degeneration, Dry

Ospedale San Raffaele

Not applicable

Genova, Milan, Rome

2021-03-16

Recruiting

FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae

NCT04759001Enterobacteriaceae Infections, Multi-antibiotic Resistance

DrugDonor - FMT

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase 1/2

Rome

2021-02-18

Recruiting

Sbrt±sTad for Unfavorable iNtermediate rIsk/High Risk Prostate caNcer

NCT05557604Prostate Cancer

DrugLeuprolide Acetate

Regina Elena Cancer Institute

Phase 2

146

Rome

2021-02-02

By invitation

A Long-term Follow-up Study in Participants Who Received CTX001

NCT04208529Beta-Thalassemia, Thalassemia, Sickle Cell Disease, Hematologic Diseases

DrugExa-cel

Vertex Pharmaceuticals Incorporated

Phase 3

160

Rome

2021-01-20

Active, closed

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

NCT04589845Solid Tumors

DrugsCamonsertib·Belvarafenib·Pralsetinib·Divarasib

Hoffmann-La Roche

Phase 2

920

Rome, Brescia, Milan, Turin, Siena

2021-01-18

Active, closed

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

NCT04657991Melanoma

DrugsBinimetinib·Encorafenib·Keytruda·Pembrolizumab

Pfizer

Phase 3

257

Udine, Milan, San Sisto, Roma, Rome, Siena, Candiolo, Bari

2021-01-15

Active, closed

Deciphering the Molecular Traits of Non-canonical Responders to Advance Personalized Therapy in Gastric Cancer

NCT06877910Metastatic Gastric Cancer

Regina Elena Cancer Institute

Observational

220

Rome

2021-01-10

Active, closed

Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)

NCT04634877Endometrial Neoplasms

DrugsDocetaxel·Keytruda·Paclitaxel·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

990

Roma, Rome, Milan, Candiolo, Brescia, Naples, Padova

2021-01-10

Recruiting

Predictive Factors for Survival in Aggressive Meningiomas

NCT05793034Meningioma, Meningioma Atypical, Anaplastic Meningioma

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

250

Rome

2021-01-07

Recruiting

NobleStitch EL STITCH Trial is a PFO Comparative Trial

NCT04339699Foramen Ovale, Patent, Stroke, Ischemic

Nobles Medical Technologies II Inc

Not applicable

640

Rome

2021-01-01

Recruiting

SBRT in Early Breast Cancer in Elderly Women

NCT05071105Breast Neoplasm Female

University of Rome Tor Vergata

Not applicable

Rome

2021-01-01

Recruiting

Real-Life Chronic Rhinosinusitis Outcome Registry

NCT04670172Chronic Rhinosinusitis (Diagnosis)

Change Accelerator in Respiratory Care

Observational

4,550

Rome

2021-01-01

Active, closed

A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer

NCT04538742Metastatic Breast Cancer

DrugsTucatinib·Pertuzumab·Trastuzumab deruxtecan·Durvalumab

AstraZeneca

Phase 1/2

245

Bologna, Milan, Naples, Rome

2020-12-28

Active, closed

The Efficacy of Upper Limb Rehabilitation With Exoskeleton in Patients With Subacute Stroke.

NCT04697368Stroke, Upper Extremity Paresis

IRCCS San Raffaele Roma

Not applicable

Bologna, Ferrara, Foggia, Messina, Roma, Rome, San Giovanni Rotondo

2020-12-28

Active, closed

Pullback Pressure Gradient (PPG) Global Registry

NCT04789317Chronic Coronary Insufficiency, Non ST Elevation Myocardial Infarction

VZW Cardiovascular Research Center Aalst

Observational

982

Ferrara, Rome

2020-12-23

Active, closed

International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach

NCT04572230Intracranial Aneurysm

Stryker Neurovascular

Observational

405

Florence, Genova, Milan, Rome

2020-12-21

Active, closed

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

NCT04640623Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 2

220

Bari, Florence, Genova, Milan, Pisa, Roma, Rome, Torino

2020-12-18

Active, closed

Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

NCT04794101X-Linked Retinitis Pigmentosa

MeiraGTx Ocular UK Ltd

Phase 3

Florence, Milan, Naples, Rome

2020-12-04

Active, closed

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)

NCT04548999Multiple Sclerosis

DrugsOcrelizumab·Methylprednisolone

Hoffmann-La Roche

Phase 3

769

Naples, Rome, Gallarate, Milan, Pavia, Turin

2020-12-03

Active, closed

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

NCT04544436Multiple Sclerosis

DrugsOcrelizumab·Methylprednisolone

Hoffmann-La Roche

Phase 3

864

Chieti, Naples, Rome, Milan, Pozzilli

2020-11-26

Active, closed

Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

NCT04623541Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Treatment-naïve High Risk Chronic Lymphocytic Leukemia

DrugsEpcoritamab·Pirtobrutinib·Lenalidomide·Venetoclax

Genmab

Phase 1/2

194

Bologna, Torino, Ferrara, Meldola, Rome, Roma, Brescia, Milan

2020-11-25

Recruiting

Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

NCT03963622ARDS

Unity Health Toronto

Not applicable

740

Ferrara, Foggia, Rome

2020-11-23

Active, closed

Evaluation of Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk

NCT04829929Non-Valvular Atrial Fibrillation

Eclipse Medical Ltd.

Not applicable

200

Rome

2020-11-17

Active, closed

RADIANT: A Study of Radium-223 Dichloride (Xofigo) vs Enzalutamide or Abiraterone (ARPIs, Androgen Receptor Pathway Inhibitors) in Patients With Prostate Cancer That Has Spread to the Bones (mCRPC, Metastatic Castration-Resistant Prostate Cancer)

NCT04597125Metastatic Castrate Resistant Prostate Cancer (mCRPC)

Bayer

Phase 4

654

Ferrara, Modena, Parma, Aviano, Rome, Genoa, Milan, Alessandria

2020-11-09

Active, closed

Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy

NCT04281485Duchenne Muscular Dystrophy

Pfizer

Phase 3

114

Roma, Rome

2020-11-05

Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor

DrugsRezatapopt·Keytruda·Pembrolizumab

PMV Pharmaceuticals, Inc

Phase 1/2

300

Rome, Milan, Rozzano, Candiolo, Naples

2020-10-29

Active, closed

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis

NCT04544449Multiple Sclerosis, Primary Progressive

DrugsFenebrutinib·Ocrelizumab

Hoffmann-La Roche

Phase 3

985

Naples, Parma, Rome, Genoa, Milan, Montichiari, Pozzilli, Palermo

2020-10-26

Active, closed

Myasthenia Gravis Inebilizumab Trial

NCT04524273Myasthenia Gravis

DrugInebilizumab

Amgen

Phase 3

238

Milan, Pavia, Rome

2020-10-15

Active, closed

A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Palbociclib·Letrozole

Hoffmann-La Roche

Phase 3

992

Meldola, Rome, Brescia, Milan, Monza, Misterbianco (CT), Candiolo, Livorno

2020-10-09

Active, closed

Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)

NCT04524611Crohn's Disease (CD)

DrugsSkyrizi·Risankizumab·Ustekinumab

AbbVie

Phase 3

527

Bologna, Genoa, Milan, Rho, Rome, Negrar, Cagliari, Palermo

2020-09-30

Active, closed

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

NCT04432584Paroxysmal Nocturnal Hemoglobinuria

DrugsCrovalimab·Eculizumab

Hoffmann-La Roche

Phase 3

190

Ravenna, Rome, Milan, Turin, Florence

2020-09-30

Active, closed

Chemo-Radiotherapy Boost Treatment Guided by Perfusion MRI on Hypoxic Zones in Head and Neck Cancer

NCT06880289Squamous Cell Tumors of the Head and Neck

Regina Elena Cancer Institute

Phase 2

Roma, Rome

2020-09-16

Recruiting

Rediscovering Biomarkers for the Diagnosis and Early Treatment Response in NEN (REBORN)

NCT04464122Neuroendocrine Tumors, Neuroendocrine Neoplasm, Neuroendocrine Tumor Grade 1, Neuroendocrine Tumor Grade 2

University of Roma La Sapienza

Observational

Rome

2020-09-14

Active, closed

Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome

NCT04401748Myelodysplastic Syndrome (MDS)

DrugsVenclexta·Azacitidine·Venetoclax

AbbVie

Phase 3

531

Rozzano, Naples, Rome, Bologna, Reggio Calabria

2020-09-10

Active, closed

A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

NCT04442022Relapsed/Refractory Diffuse Large B-cell Lymphoma

DrugsSelinexor·Rituximab·Dexamethasone·Gemcitabine

Karyopharm Therapeutics Inc

Phase 2/3

501

Ancona, Caserta, Naples, Novara, Pescara, Rome, Palermo, Turin

2020-09-03

Active, closed

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

NCT04468984Myelofibrosis (MF)

DrugsNavitoclax·Ruxolitinib

AbbVie

Phase 3

330

Bologna, Florence, Rome, Monza, Naples, Turin, Ancona, Bergamo

2020-08-31

Active, closed

Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

NCT04498117Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma

DrugsOregovomab·Paraplatin·Taxol·Paclitaxel

CanariaBio Inc.

Phase 3

615

Rome, Monza

2020-08-25

Active, closed

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

NCT04482309Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer, Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 2

477

Milan, Naples, Rome

2020-08-18

Recruiting

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

NCT04575935Advanced Ovarian Carcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Tumor, Fallopian Tube Serous Neoplasm

M.D. Anderson Cancer Center

Phase 3

580

Bologna, Rome

2020-08-05

Active, closed

A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)

NCT03992430Muscular Dystrophy, Duchenne

DrugEteplirsen

Sarepta Therapeutics, Inc.

Phase 3

160

Genova, Rome

2020-07-13

Active, closed

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

NCT04380636Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

DrugsParaplatin·Taxol·Olaparib·Etoposide

Merck Sharp & Dohme LLC

Phase 3

870

Torrette, Rome, Rozzano, Florence, Lecce, Milan, Modena, Udine

2020-07-06

Active, closed

Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia

NCT04258943Philadelphia Chromosome Positive CML, Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia, Chronic Phase Chronic Myelogenous Leukemia

DrugBosutinib

Children's Oncology Group

Phase 1/2

Monza, Rome, Torino

2020-07-06

Recruiting

Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients

NCT05793203Rejection Acute Hepatic, Transplant; Failure, Liver, Liver Dysfunction

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Rome

2020-07-06

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)

NCT04241185Urinary Bladder Neoplasms

DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda

Merck Sharp & Dohme LLC

Phase 3

520

Bari, Rome, Milan, Florence, Modena, Naples, Province of Macerata

2020-05-19

Recruiting

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

NCT04094610Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors

DrugRepotrectinib

Turning Point Therapeutics, Inc.

Phase 1/2

Milan, Padova, Rome, Torino

2020-03-12

Recruiting

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

NCT04294927BRCA1 Gene Mutation, BRCA2 Gene Mutation, RAD51C Gene Mutation, RAD51D Gene Mutation

University Medical Center Nijmegen

Not applicable

3,000

Bologna, Milan, Monza, Rome

2020-03-01

Recruiting

Covid-19 in Hematological Malignancies

NCT04733729COVID-19 Infection in Hematological Malignancies Patients

Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne

Observational

3,000

Brescia, Naples, Rome, Varese, Verona

2020-03-01

Active, closed

Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)

NCT04199689Papillomavirus Infections

DrugNonavalent HPV vaccine

Merck Sharp & Dohme LLC

Phase 3

6,033

Rome, Padova, Bari, Catania, Roma

2020-02-27

Active, closed

Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

NCT04262466Select Advanced Solid Tumors

DrugBrenetafusp

Immunocore Ltd

Phase 1/2

410

Rome, Seriate, Naples

2020-02-25

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

NCT04194944Non-Small Cell Lung Cancer

DrugsSelpercatinib·Pemetrexed·Cisplatin·Carboplatin

Eli Lilly and Company

Phase 3

261

Naples, Ravenna, Aviano, Rome, Monza, Milan, Rozzano, Orbassano

2020-02-17

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

NCT04211337Medullary Thyroid Cancer

DrugsVandetanib·Selpercatinib·Cabozantinib

Loxo Oncology, Inc.

Phase 3

291

Naples, Rome, Milan, Turin, Pisa, Siena, Padova, Catania

2020-02-11

Recruiting

Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors

NCT03934372Acute Myeloid Leukemia, Accelerated Phase Chronic Myeloid Leukemia, Blast Phase Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia

DrugPonatinib

Incyte Biosciences International Sàrl

Phase 1/2

Bologna, Brescia, Genova, Milan, Monza, Naples, Pavia, Rome

2020-01-29

Active, closed

A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis

NCT04075266Multiple Sclerosis

Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance

Hoffmann-La Roche

Phase 2

Rome, Catania

2020-01-09

Active, closed

Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis

NCT03989206Moderate-to-Severe Atopic Dermatitis

DrugNemolizumab

Galderma R&D

Phase 3

1,700

Bologna, L’Aquila, Roma, Rome, Rozzano, Vicenza

2019-12-30

Recruiting

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

NCT04071847Movement Disorders, Parkinson Disease, Essential Tremor, Tremor

Abbott Medical Devices

Observational

1,000

Cona, Rome, Milan

2019-11-26

Active, closed

NCT04150068HIV-1-infection

DrugLenacapavir

Gilead Sciences

Phase 2/3

Bergamo, Brescia, Milan, Roma, Rome

2019-11-21

Active, closed

A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm

NCT04041050Myeloproliferative Neoplasm

DrugsNavitoclax·Celebrex·Celecoxib·Ruxolitinib

AbbVie

Phase 1

Rome, Brescia, Meldola

2019-11-08

Recruiting

Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta (β)-Thalassemia

NCT04143724Beta-Thalassemia

DrugLuspatercept

Celgene

Phase 2

Rome, Genoa, Naples, Orbassano

2019-11-07

Recruiting

Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)

NCT04032470Essential Tremor

Boston Scientific Corporation

Observational

500

Rome

2019-10-23

Active, closed

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

NCT03975647HER2-positive Breast Cancer

DrugsTucatinib·Trastuzumab emtansine

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

466

Torrette, Bologna, Rome, Faenza, Lugo, Cattolica, Milan, Ravenna

2019-10-02

Recruiting

Multivirus-specific T-cell Transfer Post SCT vs AdV, CMV and EBV Infections

NCT04832607AdV Infection, EBV Infection, CMV Infection, Stem Cell Transplant Complications

Tobias Feuchtinger

Phase 3

149

Rome, Turin

2019-08-27

Active, closed

A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

NCT04035005Multiple Sclerosis, Primary Progressive

Hoffmann-La Roche

Phase 3

1,013

Naples, Rome, Genoa, Milan, Pavia, Orbassano, Cefalù

2019-08-12

Active, closed

A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer

NCT03981796Neoplasms

DrugsNiraparib·Dostarlimab·Paclitaxel·Carboplatin

Tesaro, Inc.

Phase 3

785

Candiolo, Carpi MO, Lecce, Milan, Naples, Ponderano BI, Rome, Sassuolo

2019-07-18

Active, closed

A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor

NCT04008797Endometrial Neoplasms, Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms

DrugsE7386·Doxorubicin·Lenvatinib·Paclitaxel

Eisai Inc.

Phase 1/2

301

Ancona, Milan, Rome

2019-07-11

Active, closed

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis

NCT03725007Juvenile Idiopathic Arthritis (JIA)

A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy

AbbVie

Phase 1

124

Rome

2019-06-24

Recruiting

Bacille Calmette-Guérin (BCG) Vaccine In Radiologically Isolated Syndrome (RIS)

NCT03888924Multiple Sclerosis

S. Andrea Hospital

Phase 2

100

Rome

2019-06-17

Active, closed

Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)

NCT03992417Dermatitis Atopic

DrugDupilumab

Sanofi

Observational

955

Torrette Di Ancona, Terracina, Rome, Bari, Brescia, Cagliari, Genova, L’Aquila

2019-06-11

Active, closed

Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

NCT03969004Cutaneous Squamous Cell Carcinoma

DrugCemiplimab

Regeneron Pharmaceuticals

Phase 3

415

Bergamo, Bologna, Brescia, Florence, L’Aquila, Milan, Naples, Rome

2019-06-04

Active, closed

PROSpect: Prone and Oscillation Pediatric Clinical Trial

NCT03896763Acute Respiratory Distress Syndrome in Children

University of Pennsylvania

Not applicable

600

Florence, Rome, Genova

2019-05-01

Active, closed

Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients.

NCT03913481C.Surgical Procedure; Cardiac

Università Vita-Salute San Raffaele

Not applicable

2,000

Cotignola, Catania, Lecce, Milan, Padua, Pisa, Potenza, Rome

2019-04-15

Active, closed

NCT03675308Psoriatic Arthritis

AbbVie

Phase 3

964

Modena, Ancona, Catania, Rome, Verona

2019-03-25

Active, closed

Durvalumab and Tremelimumab for Pediatric Malignancies

NCT03837899Pediatric Cancer, Solid Tumor Pediatric, Hematological Malignancies

DrugDurvalumab

AstraZeneca

Phase 1/2

Genova, Milan, Rome, Torino

2019-03-07

Active, closed

A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

NCT03673501Gastrointestinal Stromal Tumors

DrugsRipretinib·Sunitinib

Deciphera Pharmaceuticals, LLC

Phase 3

453

Bologna, Meldola, Milan, Padova, Palermo, Rome

2019-02-08

Recruiting

Body Mass Index (BMI) and Quality of Life (QoL) in Cancer Patients

NCT03873064Neoplasm Malignant, Body Weight, Quality of Life

University of Rome Tor Vergata

Observational

1,380

Rome

2019-01-15

Recruiting

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations

NCT04127552Adrenal Incidentaloma, Hypercortisolism, Adrenal Tumor

University of Roma La Sapienza

Observational

Rome

2019-01-02

Recruiting

SAPT Versus DAPT in Incomplete Revascularization After CABG

NCT03789916Coronary Artery Disease

DrugsAcetylsalicylic acid·Ticagrelor

Campus Bio-Medico University

Phase 3

800

Rome

2019-01-02

Active, closed

Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

NCT03539536Non-small Cell Lung Cancer

DrugTelisotuzumab vedotin

AbbVie

Phase 2

270

Bologna, Meldola, Milan, Naples, Rome, Orbassano, Avellino, Parma

2018-10-10

Recruiting

Extension Study for the Port Delivery System With Ranibizumab (Portal)

NCT03683251Neovascular Age-Related Macular Degeneration

DrugPDS Implant with Ranibizumab

Hoffmann-La Roche

Phase 3

1,000

Chieti, Bari, Trieste, Rome, Milan, Torrette - Ancona, Florence, Perugia

2018-09-20

Active, closed

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis

NCT03398135Ulcerative Colitis (UC)

AbbVie

Phase 3

1,242

Genoa, Rozzano, Milan, Rho, Rome, Negrar, Bologna, Catania

2018-08-28

Recruiting

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

NCT03486873Solid Tumors, Hematologic Malignancies

DrugsPembrolizumab/Favezelimab·) Berahyaluronidase alfa·Olaparib·Lenvatinib

Merck Sharp & Dohme LLC

Phase 3

3,500

Bologna, Rome, Milan, Monza, Rozzano, Aviano, Catania, Candiolo

2018-08-21

Active, closed

A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer

NCT03456076Carcinoma, Non-Small-Cell Lung

DrugsAlectinib·Vinorelbine·Pemetrexed·Gemcitabine

Hoffmann-La Roche

Phase 3

257

Naples, Rome, Milan, Orbassano, Perugia

2018-08-16

Active, closed

Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood

NCT03793478Acute Myeloid Leukemia

DrugsQuizartinib·Cytarabine·Etoposide·Fludarabine

Daiichi Sankyo

Phase 1/2

Monza, Rome, Torino

2018-08-15

Active, closed

A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis

NCT03568318Atopic Dermatitis

AbbVie

Phase 3

1,533

Rome, Rozzano, Ancona, Catania, Milan, Naples

2018-08-09

Recruiting

A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)

NCT02991469Juvenile Idiopathic Arthritis

DrugSarilumab

Sanofi

Phase 2

Genoa, Milan, Rome

2018-08-09

Active, closed

Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)

NCT03513614Node-positive Breast Cancer

University Hospital, Basel, Switzerland

Not applicable

1,500

Castellanza, Rome

2018-08-07

Recruiting

Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

NCT03435796Neoplasms

Celgene

Phase 2/3

1,541

Ancona, Bologna, Milan, Monza, Naples, Roma, Rome, Rozzano (MI)

2018-07-19

Active, closed

A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

NCT03519945Ulcerative Colitis

DrugMirikizumab

Eli Lilly and Company

Phase 3

1,058

Catanzaro, Genova, Pisa, Rho, Roma, Rome, Rozzano, Torino

2018-07-18

Active, closed

Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors

NCT03485209Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Exocrine Pancreatic Cancer, Carcinoma, Squamous Cell of Head and Neck

DrugsTisotumab Vedotin·Tivdak·Keytruda·Cisplatin

Seagen, a wholly owned subsidiary of Pfizer

Phase 2

350

Meldola (Fc), Ravenna, Meldola (FC), Rome, Brescia, Milan, Cattolica, Rimini

2018-06-25

Recruiting

Natural History of SMA

NCT05755451Muscular Atrophy, Spinal

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

1,200

Genova, Messina, Milan, Rome

2018-06-21

Active, closed

A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

NCT03523858Progressive Multiple Sclerosis (PMS)

Hoffmann-La Roche

Phase 3

927

Bari, Naples, Trieste, Rome, Genoa, Milan, Pavia, Pozzilli

2018-05-28

Recruiting

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

NCT03564340Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer

DrugsUbamatamab·Sarilumab·Cemiplimab·Tocilizumab

Regeneron Pharmaceuticals

Phase 1/2

890

Rome, Milan, Naples

2018-05-21

Active, closed

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

NCT03466411Crohn's Disease

DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3·Ustekinumab

Janssen Research & Development, LLC

Phase 2/3

1,409

Bologna, Cagliari, Cento, Messina, Milan, Padova, Roma, Rome

2018-04-13

Active, closed

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease

NCT03105102Crohn's Disease

AbbVie

Phase 3

1,336

Torrette, Genoa, Rozzano, Milan, Rho, Rome, Florence, Negrar

2018-04-09

Active, closed

Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow

NCT03363373Neuroblastoma

DrugsNaxitamab·Gm-Csf

Y-mAbs Therapeutics

Phase 2

122

Genoa, Milan, Rome

2018-04-03

Recruiting

Surgical or Medical Treatment of Breast Cancer Metastasis: A Multicentre Observational Study

NCT06093022Breast Cancer, Liver Metastases

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

720

Rome

2018-04-01

Active, closed

Development of Novel Clinical Endpoints in Intermediate AMD

NCT03349801Age Related Macular Degeneration (AMD)

Frank G. Holz

Observational

718

Milan, Rome

2018-03-26

Active, closed

A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433

NCT03345823Crohn's Disease

AbbVie

Phase 3

747

Bologna, Rozzano, Milan, Rome, Negrar, Catania, Catanzaro, Genova

2018-03-21

Recruiting

Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia A Patients

NCT03695978Haemophilia A

Octapharma

Observational

200

Bari, Bologna, Castelfranco Veneto, Catania, Florence, Milan, Padova, Rome

2018-02-13

Active, closed

Safety/PK Study of Gene Modified Donor T Cell Infusion in Children With Recurrent Hem Malignancies After Allo Transplant

NCT03459170Hematologic Malignancy

DrugsBPX-501 T cells·Rimiducid

Bellicum Pharmaceuticals

Phase 1

Pavia, Rome, Turin

2018-02-01

Recruiting

Randomization of Single vs Multiple Arterial Grafts

NCT03217006Coronary Artery Disease, Heart Diseases

Weill Medical College of Cornell University

Not applicable

4,300

Bari, Brescia, Cotignola, Roma, Rome, Torino

2018-01-07

Active, closed

ORANGE SEGMENTS: Open Versus Laparoscopic Parenchymal Preserving Postero-Superior Liver Segment Resection

NCT03270917Liver Surgery

Maastricht University Medical Center

Not applicable

250

Brescia, Milan, Rome

2017-11-01

Active, closed

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

NCT03178552Non-Small Cell Lung Cancer

DrugsCobimetinib·Divarasib·Vemurafenib·Entrectinib

Hoffmann-La Roche

Phase 2/3

1,000

Naples, Meldola, Aviano, Rome, Bergamo, Cremona, Milan, Monza

2017-09-22

Active, closed

A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)

NCT03148418Cancer

DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab

Hoffmann-La Roche

Phase 3

382

Naples, Modena, Rome, Genoa, Milan, Monza, Novara, Orbassano

2017-09-20

Recruiting

Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)

NCT03016819Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Soft-Tissue Sarcoma

DrugsCatequentenib·Digoxin·Dacarbazine·Rosuvastatin

Advenchen Laboratories, LLC

Phase 3

325

Milan, Palermo, Rome

2017-08-15

Active, closed

Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer

NCT03155997Breast Cancer

DrugAbemaciclib

Eli Lilly and Company

Phase 3

5,637

Naples, Cona, Meldola, Monza, Milan, Rozzano, Rome, Terni

2017-07-12

Active, closed

The OCTOBER Trial - European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction (OCTOBER)

NCT03171311Ischaemic Heart Disease, Ischemic Heart Disease

Aarhus University Hospital Skejby

Not applicable

1,201

Ferrara, Rome

2017-07-05

Recruiting

Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease

NCT02986516Chordoma

Italian Sarcoma Group

Not applicable

100

Milan, Bologna, Florence, Pavia, Pisa, Rome, Trento

2017-03-16

Active, closed

Prospective Registry for Patients Undergoing Surgery for Male Stress Urinary Incontinence

NCT02757274Urinary Incontinence, Stress

European Association of Urology Research Foundation

Observational

1,054

Rome

2017-02-22

Active, closed

Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor

NCT03069469Advanced Malignant Neoplasm, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor

DrugVimseltinib

Deciphera Pharmaceuticals, LLC

Phase 1/2

120

Bologna, Milan, Rome

2017-02-16

Active, closed

LEADERS FREE II: BioFreedom™ Pivotal Study

NCT02843633Acute Coronary Syndrome, High Bleeding Risk

Biosensors Europe SA

Not applicable

1,203

Milan, Rome

2017-02-14

Active, closed

A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy

NCT02993523Acute Myeloid Leukemia (AML)

DrugsAzacitidine·Venetoclax

AbbVie

Phase 3

443

Lecce, Rome, Ancona, Bergamo, Bologna, Genova, Milan, Naples

2017-02-02

Active, closed

A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

NCT03006068Ulcerative Colitis (UC)