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Clinical Trials in Italy / NCT04127552
Recruiting Observational

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations

NCT04127552 · tracked via the Priya Life Science Italy tracker
Sponsor
University of Roma La Sapienza
Phase
Observational
Started
2019-01-02
Last updated
2025-03-28

Condition(s) studied

Adrenal IncidentalomaHypercortisolismAdrenal Tumor

Investigational drug(s) / intervention(s)

Adrenalectomy

Adrenalectomy: Adrenalectomy according to 2016 ESE guidelines

Study summary

The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS). Investigators hypothesize that adrenalectomy in selected patients, following the 2016 European Congress of Endocrinology (ECE) guidelines, can improve metabolic parameters and cardiovascular risks and features.

Eligibility

Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Incidentally detected adrenal mass Exclusion Criteria: * Patients with overt Cushing's syndrome, pheochromocytoma, Conn syndrome, adrenocortical carcinoma, late-onset congenital adrenal hyperplasia, adrenal metastasis and adrenal hemorrhage * Patients taking medications influencing glucocorticoid production or metabolism * Patients with psychiatric diseases or alcohol abuse * Pregnancy

Primary outcome measure(s)

  • Echocardiographic Change of Left Ventricular Hypertrophy — at Baseline (T0) and after 1 year (t1) and 5 years (t2)
    Change of Left Ventricular Hypertrophy will be evaluated by transthoracic echocardiography. Patients will be examined in the left lateral decubitus position according to the American Society of Echocardiography guidelines.

Trial sites (1)

FacilityCityRegionStatus
Department of Experimental Medicine Rome Italy Recruiting

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Other trials for the same condition

Clinical Outcome of Autonomous Cortisol Secretion in Adrenal Incidentalomas Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04127552 on ClinicalTrials.gov ↗ ← All trials in Italy