Clinical trial register · Italy

Clinical Trials in Roma, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6791 matching records held by the registry are in this view. Synced 11 Oct 2026, 03:19 UTC

6791

Studies in scope

all four open statuses

4079

Recruiting now

open to new participants

1019

Lead sponsors

across recruiting studies

Top sites

Milan 2846 Bologna 1303 Roma 1272 Naples 983 Rome 968

Trials with a site in Roma

Status

Study

Lead sponsor

Phase

Enrol

Sites in Italy

Start

Not yet open

Ophthalmic Artery Doppler in the Puerperium After Hypertensive Disorders of Pregnancy (OPHELIA-PP)

NCT07841795Hypertensive Disorders of Pregnancy, Pre-eclampsia, Postpartum Hypertension, Puerperal Disorders

University of Roma La Sapienza

Observational

366

Roma

2027-01-01

Not yet open

A Study to Assess the Safety and Tolerability of BMS-986527 in Participants With Clear Cell Renal Cell Carcinoma (ccRCC)

NCT07848295Clear Cell Renal Cell Carcinoma (ccRCC)

DrugsCabozantinib·Opdivo·Nivolumab

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 1

112

Rozzano, Roma

2026-12-31

Not yet open

Stratification and Treatment in Early Psychosis Study - PROMOTE

NCT07434973Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis, Clinical High Risk for Developing Psychosis

DrugCannabidiol

University of Oxford

Phase 3

586

Bari, Naples, Pavia, Roma

2026-12-01

Not yet open

Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy

NCT07086183Aneurysm Cerebral

Mayo Clinic

Observational

100

Roma

2026-12-01

Not yet open

IntraOperative UltraSound Guided vs Wire Guided vs Magnetic Seed Guided Breast-Conserving Surgery for Non-palpable Tumors

NCT07185568Breast Cancer, Breast-Conserving Surgery

Istituto Oncologico Veneto IRCCS

Not applicable

1,302

Roma, Modena, Ortona, Padova

2026-11-04

Not yet open

Phase II Study of Upfront SRT Plus Ivonescimab/Chemotherapy vs Ivonescimab/Chemotherapy in NSCLC Brain Mets

NCT07234877Non Small Cell Lung Cancer

DrugsPaclitaxel-albumin·Ivonescimab·Pemetrexed·Paclitaxel

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

158

Brescia, Milan, Roma, Udine

2026-11

Recruiting

Pre-marketing Trial to Assess Safety and Efficacy of 'Volumizing Filler Based on Hyaluronic Acid and Recombinant Collagen'

NCT06336044Wrinkle, Scar, Laxity; Skin

Taumedika s.r.l.

Not applicable

Roma

2026-11

Not yet open

Development of the SC-IBD Self-Care Measurement Scale

NCT07494227Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

275

Roma

2026-10-30

Not yet open

Evaluation of the Safety and Effectiveness of the Novel Medtronic Experimental Automated Insulin Delivery System (NMX8) in Adults Living With Type 1 Diabetes

NCT07401901Type 1 Diabetes (T1D)

Medtronic MiniMed, Inc.

Not applicable

230

Bologna, Milan, Naples, Roma

2026-10-15

Not yet open

Fetal Ovarian Cysts and IOTA Terminology for Perinatal Management

NCT07587580Fetal Ovarian Cyst, Neonatal Ovarian Cyst

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Roma

2026-10-11

Not yet open

Patients With Cryptogenic Hypertransaminasemia

NCT07834125Cryptogenic Hypertransaminasemia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-10-01

Not yet open

A Master Regulator of Lipid-Associated Macrophage Function in Cancer

NCT07848061Breast Cancer, Head & Neck Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

120

Roma

2026-10-01

Not yet open

Pelvic Floor Ultrasound Before Induction of Labour and Labour Outcome

NCT07797387Labor, Pelvic Floor Disorder, Labor Stage, Second, Induced Labor

University of Roma La Sapienza

Observational

140

Roma

2026-10-01

Not yet open

Testing a New Gold Nanoparticle-Based Lithium Delivery Method for Bipolar Disorder in Laboratory Models

NCT07732933Bipolar Disorder (BD), Bipolar Disorder (BPD)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2026-10-01

Not yet open

Remote Monitoring and Optimization of Heart Failure Therapy

NCT07622472Heart Failure

Zoll Medical Corporation

Not applicable

800

Roma

2026-10-01

Not yet open

Photobiomodulation Laser for Reticular Pseudodrusen in Age-Related Macular Degeneration

NCT07554690AMD - Age-Related Macular Degeneration

Fondazione G.B. Bietti, IRCCS

Not applicable

Roma

2026-10

Recruiting

A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.

NCT07559175Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF), Pancreatic Enzyme Abnormality, Pancreatic Diseases

DrugZenpep

Aimmune Nestlé Health Science US R&D, LLC

Phase 2

Catania, Rozzano, Messina, Florence, Milan, Roma

2026-10

Recruiting

FIBRONEER-ACT: A Study to Test Whether Nerandomilast Helps People With Fibrosing Interstitial Lung Disease at Risk for Disease Progression

NCT07540988Interstitial Lung Diseases

DrugNerandomilast

Boehringer Ingelheim

Phase 3

466

Catania, Foggia, Forlì, Milan, Monza, Padova, Roma

2026-09-17

Recruiting

A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis

NCT07412704Arthritis, Rheumatoid

Bristol-Myers Squibb

Phase 1/2

Rozzano, Roma

2026-09-15

Not yet open

Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome

NCT07801404Dravet Syndrome (DS)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Ancona, Florence, Genova, Messina, Milan, Roma, Rome, Verona

2026-09-15

Recruiting

A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum

NCT07811193Colorectal Adenocarcinoma

DrugsVVD-133214·Pembrolizumab

Vividion Therapeutics, Inc.

Phase 2

140

Milan, Naples, Roma, Rozzano

2026-09-11

Not yet open

Patients With Hepatocellular Carcinoma (HCC)

NCT07690683Hepatocellular Carcinoma, Hepatocellular Cancer, Liver Diseases, Liver Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2026-09-01

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 Skipping

NCT07587242Muscular Dystrophies, Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy), Muscular Disorders, Atrophic, Muscular Disease

DrugAOC 1044

Avidity Biosciences, Inc.

Phase 3

Genova, Milan, Roma

2026-09-01

Not yet open

Prophylactic Mesh Reinforcement Versus Primary Closure After Emergency Midline Laparotomy (PREEMPT)

NCT07753551Incisional Hernia After Midline Laparotomy, Emergency Abdominal Surgery

University of Rome Tor Vergata

Not applicable

189

Roma

2026-09-01

Recruiting

Insomnia and Post-Dental Surgery Pain: A Prospective Study

NCT07712432Dental, Dental Extraction, Insomnia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-09-01

Not yet open

Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT

NCT07544277FFR-CT, CT Angiography, CT Perfusion, Coronary Arterial Disease (CAD)

IRCCS San Raffaele

Observational

142

Roma, Milan

2026-09-01

Recruiting

A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

NCT07625215Atrial Fibrillation

Bayer

Phase 2

360

Acquaviva delle Fonti, Milan, Roma, Torrette

2026-09-01

Not yet open

Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables

NCT07533084Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia

Neuromed IRCCS

Observational

265

Brescia, Genova, Pozzilli, Milan, Pavia, Roma, Venezia

2026-09

Not yet open

HERCULES: Ultrasound-Based Liver Involvement Classification in Ovarian Cancer

NCT07808320Ovarian Cancer, Recurrent Ovarian Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-09

Not yet open

Machine Learning Algorithms Incorporating Radiomic Ultrasound Features

NCT07793201Adnexal Masses

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

12,000

Roma

2026-09

Not yet open

SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer

NCT07695519Rectal Cancer, Rectal Adenocarcinoma, Rectal Cancer Patients, Rectal Cancer, Radiotherapy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

196

Roma

2026-09

Recruiting

L19IL2/TNF in Patients With Basal Cell Carcinoma

NCT07227870Locally Advanced Basal Cell Carcinoma

DrugDaromun

Philogen S.p.A.

Phase 2

Naples, Roma, Rozzano, Siena

2026-09

Recruiting

L19IL2/L19TNF in Patients With Cutaneous Squamous Cell Carcinoma

NCT07228442Locally Advanced Cutaneous Squamous Cell Carcinoma

DrugDaromun

Philogen S.p.A.

Phase 2

Naples, Roma, Rozzano, Siena

2026-09

Not yet open

VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism

NCT07827963Parkinson's Disease, Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy

IRCCS San Raffaele Roma

Observational

Cassino, Roma

2026-09

Not yet open

Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)

NCT07817875Obesity

DrugTirzepatide

Eli Lilly and Company

Phase 3

150

Florence, Modena, Novara, Parma, Roma

2026-09

Recruiting

Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment

NCT07691970Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

1,072

Brescia, Cona, Florence, Milan, Roma

2026-08-31

Recruiting

A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy

NCT07771465Symptomatic Genetic Dilated Cardiomyopathy (DCM)

DrugDanicamtiv

Kardigan, Inc.

Phase 3

332

Bari, Florence, Milan, Padova, Pavia, Roma, Rozzano, Trieste

2026-08-26

Recruiting

AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications

NCT07797335Type 2 Diabetes, Cardiovascular Risk

DrugZenagamtide

Novo Nordisk A/S

Phase 3

1,778

Chieti, Catanzaro, Naples, Ravenna, Chiavari, Milan, Roma, Lucca

2026-08-24

Not yet open

Implementation Of A Telesurgery Program At A Referral Center For Robotic Surgery

NCT07792109Prostate Cancer, Colorectal Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma, Rome

2026-08-20

Recruiting

A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus

NCT07784725Obesity or Overweight

DrugLenbelintide

AstraZeneca

Phase 3

2,500

Bologna, Milan, Palermo, Pisa, Roma, Rozzano, Sesto San Giovanni, Torino

2026-08-19

Recruiting

A Prospective Study of Pediatric Participants up to 16 Years of Age With Methylmalonic Acidemia (MMA) Due to Mutations in the MMUT Gene

NCT07432880Methylmalonic Acidemia (MMA)

Genespire Srl

Observational

Milan, Roma

2026-08-13

Recruiting

A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving Mirikizumab Therapeutically for an Approved Indication

NCT07612267Lactation, Inflammatory Bowel Disease

DrugMirikizumab

Eli Lilly and Company

Phase 4

Lazio, Lombardia, Rho, Roma

2026-08-05

Recruiting

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study

NCT07746895C3 Glomerulopathy (C3G), Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)

DrugPegcetacoplan

Swedish Orphan Biovitrum

Phase 4

150

Bari, Bologna, Foggia, Messina, Milan, Roma, Udine

2026-08-05

Recruiting

BL-M14D1 Plus Atezolizumab vs Standard of Care in First-Line Extensive-Stage Small Cell Lung Cancer (BrenDeLL-Lung01)

NCT07625644Small Cell Lung Cancer Extensive Stage, Small-cell Lung Cancer, Small Cell Carcinoma, Sclc

DrugsEtoposide·Atezolizumab·Carboplatin

SystImmune Inc.

Phase 3

550

Aviano, Palermo, Roma, Siena

2026-08-04

Not yet open

Long-Term Extension Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon Skipping to Evaluate the Safety and Efficacy of Endosomal Escape Vehicle Phosphorodiamidate Morpholino Oligomer Platform Products (ELEVATE-LTE)

NCT07682129Duchenne Muscular Dystrophy (DMD)

DrugsENTR-601-44·ENTR-601-45

Entrada Therapeutics, Inc.

Phase 2

Milan, Roma, Rome

2026-08

Recruiting

Iron Deficiency at ICU Discharge

NCT07781540Anemia, Post ICU Syndrome, Red Blood Cell Transfusions, Iron Deficiencies

Università degli Studi di Ferrara

Observational

462

Ferrara, Roma, Siena

2026-07-29

Recruiting

Evaluation of the Efficacy and Safety of Magnetic Resonance Angiography (MRA) Using Gadopiclenol Compared to Gadoterate Meglumine in the Assessment of Steno-occlusive Disease in Adult Patients With Suspected Vascular Disease

NCT07348640Steno-occlusive Disease

DrugsGadopiclenol·Gadoterate meglumine

Guerbet

Phase 3

315

Bergamo, Cagliari, Chieti, Milan, Roma, Treviso

2026-07-28

Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

NCT07497087Systemic Sclerosis

Boehringer Ingelheim

Phase 3

448

Ancona, Bari, Florence, Milan, Modena, Naples, Roma

2026-07-27

Recruiting

Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment

NCT07444567Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES)

DrugsFasenra·Benralizumab

AstraZeneca

Phase 3

230

Roma

2026-07-24

Active, closed

Advancing Risk Stratification in Endometrial Cancer

NCT07746024Endometrial Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

400

Roma

2026-07-23

Recruiting

A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)

NCT07366034Fibrosing Interstitial Lung Disease

DrugNerandomilast

Boehringer Ingelheim

Phase 3

Genova, Roma

2026-07-21

Recruiting

Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems

NCT07842991Plaque, Dental Plaque, Gingivitis

DrugColgate Cavity Protection Toothpaste

Colgate Palmolive

Phase 3

120

Roma

2026-07-20

Recruiting

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

NCT07720284High-risk Muscle Invasive Urothelial Carcinoma

DrugsEnfortumab Vedotin·Rilvegostomig·Dato-DXd·Opdivo

AstraZeneca

Phase 3

915

Bari, Florence, Padova, Roma, Rozzano, Tricase

2026-07-16

Not yet open

Evaluation of Interactions and Group Processes in Multidisciplinary Tumor Boards in Gynecologic Oncology

NCT07645716Ovarian Neoplasms, Uterine Neoplasms

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

400

Roma

2026-07-13

Recruiting

DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy

NCT07544654Extrapulmonary Neuroendocrine Cancer (epNEC)

DrugsObrixtamig·Etoposide·Carboplatin

Boehringer Ingelheim

Phase 3

390

Bari, Florence, Milan, Naples, Palermo, Roma, Verona

2026-07-10

Recruiting

A Study to Observe the Long-term Safety of Odevixibat in Patients With Alagille Syndrome (ALGS) Who Are Receiving Ongoing Treatment

NCT07585097Alagille Syndrome

Ipsen

Observational

Florence, Naples, Padova, Roma, Torino, Udine

2026-07-10

Recruiting

LEOPARD Prospective Validation Cohort 1

NCT06723275Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma

Assistance Publique - Hôpitaux de Paris

Observational

630

Roma

2026-07-07

Recruiting

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

NCT07662213Type 2 Diabetes Mellitus

DrugsElecoglipron·Semaglutide

AstraZeneca

Phase 3

1,200

Bari, Bologna, Chieti, Milan, Modena, Naples, Roma

2026-07-06

Recruiting

Noninvasive Brain Stimulation for Cervical Dystonia

NCT07681284Cervical Dystonia

Fondazione Policlinico Universitario Campus Bio-Medico

Not applicable

Roma

2026-07-06

Recruiting

Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer

NCT07476287Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), Transformed Small Cell Lung Cancer, Lung Neoplasms

DrugPF-08634404

Pfizer

Phase 2

Roma, Orbassano, Bergamo

2026-07-02

Not yet open

Intrapartum Ultrasound for Assessment of Fetal Progression

NCT05718180Labor, Obstetric

University of Padova

Not applicable

105

Bologna, Padova, Roma

2026-07-01

Recruiting

Pridopidine Phase 3 Study in Huntington's Disease

NCT07609108Huntington Disease

DrugPridopidine

Prilenia

Phase 3

400

Bologna, Milan, Naples, Padova, Roma, San Giovanni Rotondo

2026-07-01

Recruiting

Use of Bifidobacterium Bifidum in Formula-Fed Infants With Colic, With or Without Atopic Dermatitis

NCT07754968Infant Colic, Atopic Dermatitis

University of Roma La Sapienza

Not applicable

Roma

2026-07-01

Not yet open

AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation

NCT07604727Atrial Fibrillation (AF), Heart Failure, Cardiac Pacing

University Medical Center Groningen

Not applicable

292

Florence, Lavagna, Milan, Nola, Reggio Emilia, Roma, Tricase

2026-07

Not yet open

MRI-Guided Adaptive Radiotherapy for Limited Peritoneal Metastases (MARACAS Trial).

NCT07593261Peritoneal Carcinomatosis, Oligometastatic Disease, Peritoneal Metastases

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase 2

Roma

2026-07

Not yet open

New Biomarkers for Organ Viability Assessment During Hypothermic Machine Perfusion in Liver Transplantation: the Role of Extemporaneous Histological Examination.

NCT07674394Liver Transplantation (LT), Early Allograft Dysfunction, Primary Non-function, Ischemia-Reperfusion Injury

The Mediterranean Institute for Transplantation and Advanced Specialized Therapies

Not applicable

150

Milan, Palermo, Roma

2026-07

Not yet open

Optimization of Respiratory Effort With Titrated Sedation in AHRF

NCT07679932AHRF

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-07

Recruiting

[68Ga]BED003 PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications

NCT07702292Colorectal Cancer, Epithelial Ovarian Cancer, Gastric Cancer (GC), Pancreatic Ductal Adenocarcinoma (PDAC)

Blue Earth Diagnostics

Phase 2

Bergamo, Monza, Roma, Milan

2026-06-30

Recruiting

Study of Ianalumab in Adults With Primary Immune Thrombocytopenia (ITP) and Warm-antibody Autoimmune Hemolytic Anemia (wAIHA) Who Have Previously Benefited From Ianalumab

NCT07039422Primary Immune Thrombocytopenia, Warm Autoimmune Hemolytic Anemia

DrugIanalumab

Novartis Pharmaceuticals

Phase 2

Florence, Roma, Trieste, Vicenza

2026-06-26

Recruiting

RHYthm and Myocardial Function Relationship Evaluation in Heart Diseases

NCT07491237Arrhythmia, Cardiomyopathy, Dilated, Systolic Dysfunction, Atrial Fibrillation

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

253

Roma

2026-06-23

Recruiting

Funcitonality and Safety of a Knee Device for Gait Rehabilitation in Neurological Patients

NCT07670325Stroke

Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna

Not applicable

Roma

2026-06-22

Recruiting

Panuri Performance Study

NCT07587866Pancreatic Ductal Adenocarcinoma (PDAC)

Urteste S.A

Observational

1,100

Forlì, Milan, Pavia, Pisa, Roma, Rozzano

2026-06-10

Recruiting

Developing a Tailored Neuropsychological Rehabilitation for Sturge-Weber Syndrome

NCT07655492Sturge - Weber Syndrome (SWS)

University of Roma La Sapienza

Observational

Roma

2026-06-10

Recruiting

Setting Up ctDNA Analysis on Archived Plasma Samples

NCT07546578Ovarian Cancer, Liquid Biopsy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-06-08

Active, closed

Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

NCT07468071Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer, Advanced Solid Tumors Harboring the KRAS G12C Mutation

DrugsTNO155·Opnurasib·Trametinib·Cetuximab

Novartis Pharmaceuticals

Phase 1/2

Milan, Roma

2026-06-08

Recruiting

Phase III Randomized International Open Label Clinical Trial of Treatment Intensification With Docetaxel Plus Apalutamide in Patients With Metastatic Hormone-sensitive Prostate Cancer Who Did Not Achieve a Deep PSA Response After Initial Treatment With Apalutamide: REINFORCE Trial.

NCT07333066Metastatic Hormone-sensitive Prostate Cancer

DrugsApalutamide (Erleada)·Docetaxel

Alianza multidisciplinar para la investigación de los tumores genitourinarios -GUARD

Phase 3

320

Catania, Foggia, Milan, Roma

2026-06-05

Recruiting

Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer

NCT07590934Metastatic Prostate Cancer

DrugsAZD2287·FPI-2265·Palacaparib·Docetaxel

AstraZeneca

Phase 1/2

152

Bergamo, Meldola, Milan, Roma

2026-06-03

Recruiting

A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy

NCT07498426Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)

Novartis Pharmaceuticals

Phase 3

300

Milan, Roma

2026-06-03

Active, closed

Sleep Medicine Education in Dental Schools and Residency Programs in Italian Universities

NCT07624110Sleep Apnea Syndrome, Obstructive, Dental Education, Sleep-disordered Breathing

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-06-03

Recruiting

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

NCT07519902Persistent Corneal Epithelial Defect

DrugCenegermin

Dompé Farmaceutici S.p.A

Phase 3

150

Perugia, S. Andrea Delle Fratte, Florence, Milan, Pavia, Roma

2026-06-02

Recruiting

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

NCT07192952Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)

DrugFinerenone

Bayer

Phase 3

117

Bergamo, Bologna, Genova, Milan, Naples, Padova, Roma, Torino

2026-06-01

Recruiting

L19IL2 or L19TNF or L19IL2/TNF in Patients With Basal Cell Carcinoma (BCC)

NCT07227350Locally Advanced Basal Cell Carcinoma

DrugsDaromun·L19IL2·Onfekafusp alfa

Philogen S.p.A.

Phase 2

180

Naples, Roma, Rozzano, Siena

2026-06-01

Not yet open

An Open-label, Phase 2 Pilot Study on the Efficacy and Safety of Piclidenoson in Patients With Lowe Syndrome

NCT07410455Lowe Syndrome

Can-Fite BioPharma

Phase 2

Roma

2026-06-01

Not yet open

Evaluation of a Soft Elbow Exoskeleton and a Haptic Armband in Post-stroke and Parkinson's Disease Patients

NCT07637123Stroke, Parkinson Disease

IRCCS San Raffaele Roma

Not applicable

Cassino, Roma

2026-06

Recruiting

BIO|STREAM.CSP CLS

NCT07608822Sinus Node Disease, Atrioventricular Block

Biotronik SE & Co. KG

Observational

150

Brindisi, Milan, Novara, Piove di Sacco, Roma, Taranto

2026-05-29

Recruiting

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

NCT07357727Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (PPV-MF), Post-essential Thrombocythemia Myelofibrosis (PET-MF)

DrugsPelabresib·Ruxolitinib

Novartis Pharmaceuticals

Phase 3

460

Meldola, Florence, Padova, Roma, Verona, Novara

2026-05-27

Recruiting

BIO|STREAM.CSP Study

NCT07393009Cardiac Pacing, Cardiac Pacemaker, Implantable Cardioverter Defibrillator, Cardiac Resynchronization Therapy Devices

Biotronik SE & Co. KG

Observational

1,000

Brindisi, Milan, Novara, Piove di Sacco, Roma, Taranto

2026-05-25

Recruiting

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

NCT07492641HR+/HER2- Breast Cancer

DrugsBGB-43395·Abemaciclib·Ribociclib·Palbociclib

BeOne Medicines

Phase 3

1,056

Milan, Roma

2026-05-22

Recruiting

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT07422480Myelodysplastic Syndrome, Anemia

DrugsElritercept·Epoetin Alfa

Takeda

Phase 3

300

Florence, Rozzano, Pavia, Roma, Candiolo, Bologna, Milan, Naples

2026-05-21

Active, closed

Monitoring of the Sympathetic/Vagal Balance Through Multiparametric Analysis of Heart Rate Variability (HRV)

NCT07471802Diabete Type 2, Heart Failure, Kidney Disease, Chronic, Cardiorenal Syndrome

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

150

Roma

2026-05-20

Active, closed

Patients With Primary Biliary Cholangitis(PBC)

NCT07629128Primary Biliary Cholangitis, Liver Fibrosis, Cirrhosis, Liver, Blood Sugar; High

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-05-18

Not yet open

FMT for Pediatric SR-aGVHD

NCT07602751Acute Graft Versus Host Disease in Intestine

DrugFecal Microbial Transplantation

Bambino Gesù Hospital and Research Institute

Phase 1/2

Bologna, Padova, Roma

2026-05-18

Not yet open

The CORE - μFR Clinical Trial

NCT07598565Acute Coronary Syndromes (ACS), NSTEMI - Non-ST-Segment Elevation Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease

University of Roma La Sapienza

Not applicable

350

Roma

2026-05-18

Active, closed

Effects of Lokomat Training on Dynamic Postural Stability in Incomplete Spinal Cord Injury

NCT07621900Spinal Cord Injury

I.R.C.C.S. Fondazione Santa Lucia

Not applicable

Roma

2026-05-15

Recruiting

Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1

NCT07486934Myotonic Dystrophy Type 1 (DM1), DM1, Myotonic Dystrophy, Steinert Disease

DrugZeleciment basivarsen

Dyne Therapeutics

Phase 3

150

Gussago, Milan, Roma

2026-05-14

Recruiting

A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis

NCT07387549Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 3

350

Genova, Milan, Modena, Monza, Novara, Padova, Roma, Rozzano

2026-05-14

Recruiting

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

NCT07287098Breast Neoplasms

DrugsImlunestrant·Goserelin·Tamoxifen

Eli Lilly and Company

Phase 2

600

Genova, Milan, Misterbianco, Prato, Roma

2026-05-13

Recruiting

Study of INCA036978 in Participants With Myeloproliferative Neoplasms

NCT07441694Myeloproliferative Neoplasms

Incyte Corporation

Phase 1

218

Bologna, Milan, Roma, Udine

2026-05-11

Recruiting

Clostridium Butyricum in Stenosing Crohn's Disease

NCT07263880Crohn Disease (CD)

San Giovanni Addolorata Hospital

Phase 1/2

Roma

2026-05-08

By invitation

Granulation Tissue From Residual Periodontal Pockets

NCT07587606Periodontitis

University of Roma La Sapienza

Observational

Roma

2026-05-07

Recruiting

A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

NCT07415031Solid Tumors

DrugsAdagrasib·Fluorouracil·Leucovorin·Irinotecan

Mirati Therapeutics Inc.

Phase 2

170

Orbassano, Rome, Florence, Bologna, Meldola, Milan, Pesaro, Roma

2026-05-06

Recruiting

A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

NCT07483073Colitis, Ulcerative, Crohn Disease

DrugsLY4395089·Mirikizumab

Eli Lilly and Company

Phase 2

Florence, Milan, Monza, Negrar, Roma, Rozzano

2026-05-04

Recruiting

A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

NCT07483099Crohn Disease

DrugsLY4395089·Mirikizumab

Eli Lilly and Company

Phase 2

Florence, Milan, Monza, Negrar, Roma, Rozzano

2026-05-04

Recruiting

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

NCT07513376Non-small Cell Lung Cancer

DrugsPembrolizumab Formulated with Berahyaluronidase Alfa·Intismeran autogene

Merck Sharp & Dohme LLC

Phase 3

876

Bergamo, Milan, Florence, Perugia, Novara, Roma

2026-05-04

Not yet open

Benign and Malignant Adrenal Gland Surgery: Single Center Experience

NCT07577427Adrenal Gland Disease

University of Roma La Sapienza

Observational

Roma

2026-05-03

Recruiting

A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008)

NCT07519772Lymphoma, Non-Hodgkin, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse

DrugMK-1045

Merck Sharp & Dohme LLC

Phase 1/2

280

Campania, Candiolo, Milan, Roma

2026-05-03

By invitation

Empowering Postpartum Health Through Exercise

NCT07595380No Condition, Healthy Females

University of Rome Foro Italico

Not applicable

Roma

2026-05-01

Not yet open

A Phase I Study to Evaluate the Safety and Efficacy of L19IL2 in Combination With Ruxolitinib in Patients With Advanced Solid Tumors

NCT07566897Renal Carcinoma Metastatic, Pancreatic Adenocarcinoma Metastatic, Pancreatic Adenocarcinoma, Metastatic Colorectal Carcinoma (mCRC)

DrugsL19IL2·Ruxolitinib

Philogen S.p.A.

Phase 1

Roma

2026-05-01

Not yet open

Neurocognitive Assessment in Adults Undergoing CD19 Targeted CAR-T Cell Therapy

NCT07463781Diffuse Large B Cell Lymphoma (DLBCL), High Grade B Cell Lymphoma, Primary Mediastinal B-cell Lymphoma (PMBCL)

Fondazione Italiana Linfomi - ETS

Observational

100

Alessandria, Ancona, Brescia, Palermo, Reggio Calabria, Roma, Taranto, Udine

2026-05

Recruiting

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)

NCT07447648Homozygous Familial Hypercholesterolemia (HoFH), Coronary Computed Tomography Angiography

Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)

Observational

Caserta, Catania, Cinisello Balsamo, Florence, Naples, Padova, Palermo, Roma

2026-04-30

Recruiting

Study to Determine the Efficacy and Safety of Asciminib in Pediatric Patients With Ph+ CML-CP

NCT07354074Chronic Myelogenous Leukemia, Leukemia, Myelogenous, Chronic, Philadelphia Chromosome Positive

DrugsAsciminib single agent·ABL001

Novartis Pharmaceuticals

Phase 2

Roma

2026-04-28

Recruiting

A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)

NCT07419295Bladder Cancer

DrugsVinflunine·Sacituzumab tirumotecan·Docetaxel·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

590

Rozzano, Orbassano, Verona, Arezzo, Genova, Milan, Roma

2026-04-23

Active, closed

Patients With Primary Biliary Cholangitis

NCT07573514Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer, Cancer Liver

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

2,000

Roma

2026-04-23

Recruiting

Donidalorsen Treatment in Children With Hereditary Angioedema

NCT07298447Hereditary Angioedema (HAE)

DrugDonidalorsen

Ionis Pharmaceuticals, Inc.

Phase 3

Milan, Padova, Roma, San Donato Milanese

2026-04-21

Recruiting

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

NCT07499232Crohn Disease

DrugsRisankizumab·Guselkumab

Janssen Research & Development, LLC

Phase 3

530

Bologna, Bolzano, Genova, Milan, Roma, Rozzano, Torino

2026-04-21

Recruiting

EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)

NCT07287670Diffuse Cutaneous Systemic Sclerosis

Mediar Therapeutics

Phase 2

Ancona, Catania, Genoa, Milan, Modena, Roma

2026-04-16

Recruiting

A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2

NCT07203053Extensive Stage Lung Small Cell Cancer

DrugTarlatamab

ETOP IBCSG Partners Foundation

Phase 2

Meldola, Milan, Perugia, Roma

2026-04-15

Recruiting

A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus

NCT07430306Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

245

Brescia, Catania, Ferrara, Florence, Milan, Padova, Pisa, Roma

2026-04-13

Recruiting

PACE Study: School-Based Mindfulness and Compassion Interventions for Children

NCT07398781School-based Intervention, Mindfulness-based Intervention, Compassion, Emotion Regulation

IRCCS Fondazione Stella Maris

Not applicable

500

Florence, Pisa, Roma

2026-04-13

Recruiting

A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

NCT07522073Solid Tumors

DrugINCB161734

Incyte Corporation

Phase 3

588

Bologna, Brescia, Candiolo, Foggia, Milan, Naples, Pisa, Roma

2026-04-09

Recruiting

Preoperative Oncogeriatric Assessment in Patients Undergoing Hepatectomy

NCT07537569Hepatic Malignancies, Comprehensive Geriatric Assessment, Hepatectomy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

242

Roma

2026-04-09

Not yet open

Effect of Neurofast® Supplementation on Anxiety and Cardiovascular Outcomes in the Psycho-Cardio Phenotype Adults

NCT07502807Anxiety, Cardiovascular Diseases

Liaquat University of Medical & Health Sciences

Not applicable

Roma

2026-04-07

Recruiting

A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation

NCT07535112Advanced/Metastatic Colorectal Adenocarcinoma

DrugCetuximab

Bayer

Phase 1

130

Roma

2026-04-07

Recruiting

Prospective Risk Evaluation and Detection of Crohn's Disease in First-degree Relatives

NCT07316621Crohn Disease (CD)

GLSMED Learning Health S.A.

Observational

10,000

Roma

2026-04-01

Not yet open

Impact of an Omega-3 Enriched Oral Nutritional Supplement on Improving Surgical Outcomes in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery

NCT07478432Peritoneal Carcinosis, Peritoneal Metastases, HIPEC, Cytoreductive Surgery

Catholic University of the Sacred Heart

Not applicable

Roma

2026-04

Recruiting

Assessment of Sexual Well-being in Patients With Gynecologic Cancer and Their Partners: the ONCOSEX Study

NCT07557342Sexual Wellness, Gynecologic Cancers

Casa di Cura Dott. Pederzoli

Observational

200

Bologna, Padova, Roma, Trieste, Udine, Peschiera del Garda

2026-04

Recruiting

Impact of Aortic Diseases on Quality of Life and Work Ability

NCT07479186Aortic Diseases

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

300

Roma

2026-03-31

Not yet open

Efficacy of Nigella Sativa (Nisatol®) in Women With Borderline Blood Pressure Values or a Non-Dipper Blood Pressure Phenotype

NCT07494279Prehypertension, Hypertension

Liaquat University of Medical & Health Sciences

Not applicable

106

Roma

2026-03-30

Recruiting

Zanubritnib and Anti-MAG Neuropathy

NCT07392229Anti-MAG IgM-associated Demyelinating Polyneuropathy

DrugZanubrutinib

Azienda Ospedaliera di Padova

Phase 2

Milan, Padova, Pavia, Roma, Trieste

2026-03-24

Recruiting

MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)

NCT07431827Non-small Cell Lung Cancer

DrugsPembrolizumab Formulated with Berahyaluronidase Alfa·Calderasib

Merck Sharp & Dohme LLC

Phase 3

400

Milan, Roma

2026-03-18

Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

NCT07221149Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

DrugsPumitamig·Folfox·Nivolumab

Bristol-Myers Squibb

Phase 2/3

690

Naples, Turin, Padova, Milan, Roma

2026-03-13

Not yet open

Interest in Nighttime Day Hospital Chemotherapy Infusions Among Gynecologic Cancer Patients

NCT07483905Gynecologic Cancers

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

200

Roma

2026-03-12

Recruiting

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease

NCT07332481Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE)

DrugEnpatoran

EMD Serono Research & Development Institute, Inc.

Phase 3

202

Florence, Roma

2026-03-10

Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)

NCT07282574Progressive Multiple Sclerosis

DrugOcrelizumab

Hoffmann-La Roche

Phase 2

360

Chieti, Naples, Salerno, Roma, Genoa, Milan, Pavia

2026-03-10

Recruiting

Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

NCT07491445Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma

DrugsCetuximab·Nab-paclitaxel·Gemcitabine

Revolution Medicines, Inc.

Phase 3

900

Milan, Padova, Roma, Tricase, Verona

2026-03-09

Recruiting

A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

NCT07441642Geographic Atrophy Secondary to Age-related Macular Degeneration

Novartis Pharmaceuticals

Phase 2

272

Florence, Milan, Roma

2026-03-09

Recruiting

Partial Enteral Nutrition to Prevent Weight Loss and Sarcopenia in IBD Patients at Nutritional Risk - SIMBA

NCT07433946Ulcerative Colitis (Disorder), Crohn Disease, Malnutrition or Risk of Malnutrition, IBD

Lionhealth Srl Società Benefit

Not applicable

146

Rozzano, Naples, Pavia, Roma

2026-03-09

Recruiting

A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

NCT07438496Lupus Erythematosus, Systemic

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

600

Ancona, Catania, Milan, Perugia, Roma, Rozzano, Torino, Udine

2026-03-05

Recruiting

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

NCT07288398Pulmonary Hypertension Associated With HFpEF

DrugTNX-103

Tenax Therapeutics, Inc.

Phase 3

540

Acquaviva delle Fonti, Bergamo, Messina, Milan, Pavia, Pisa, Roma, Rozzano

2026-03-03

Not yet open

Clinical and Radiographic Outcomes of Alveolar Ridge Preservation

NCT07427784Alveolar Ridge Preservation

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-03-01

Recruiting

Derivation and Validation of the Aortic Valve Echocardiographic Calcium Score to Confirm Severe Aortic Stenosis: the Echo-AVCS Study

NCT07620925Aortic Stenosis, Chronic Coronary Syndrome, Calcific Aortic Valve Disease, Calcific Aortic Stenosis

Azienda Ospedaliera "Sant'Andrea"

Observational

250

Bologna, Milan, Roma

2026-03-01

Recruiting

Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)

NCT07406867Periodontal Disease, Gingivitis, Periodontitis

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Observational

2,000

Roma

2026-03-01

Not yet open

Multiparametric Ultrasound for the Noninvasive Diagnosis of Porto-sinusoidal Vascular Liver Disorder

NCT07492862Porto-sinusoidal Vascular Liver Disorder, Liver Cirrhosis, Portal Hypertension, Noncirrhotic, Portal Hypertension Related to Cirrhosis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

100

Roma

2026-03

Not yet open

Radiofrequency Ablation Multicenter Observational Study in Renal Oncology Patients

NCT07465458Renal Carcinoma

Humanitas Hospital, Italy

Observational

226

Milan, Brescia, Roma

2026-03

Not yet open

Attitudes of Dental Students Towards HIV+ Patients: a Multi-center Survey Among Italian Universities

NCT07485374HIV (Human Immunodeficiency Virus)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

480

Roma

2026-02-22

Active, closed

Modular Neurological Examination for Early Risk Detection

NCT07533162Clinical Practice Guidelines, Neurological Development

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

300

Roma

2026-02-20

Recruiting

A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004)

NCT07363590Systemic Lupus Erythematosus, Rheumatoid Arthritis

DrugMK-1045

Merck Sharp & Dohme LLC

Phase 1

Rozzano, Roma

2026-02-19

Recruiting

Monitoring Daily Mobility in Children With Autism

NCT07519369Autism Spectrum Disorder (ASD

IRCCS San Raffaele Roma

Not applicable

Roma

2026-02-18

Recruiting

A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

NCT07318558Ovarian Neoplasms, Ovarian Cancer

DrugsMvasi·Sacituzumab tirumotecan·Avastin·Bevacizumab

Merck Sharp & Dohme LLC

Phase 3

900

Brescia, Lecco, Milan, Padova, Roma, Torino

2026-02-16

Recruiting

Association of VAgus Nerve Stimulation and Treadmill Training for GAit Rehabilitation in DE Novo Parkinson's Disease

NCT07337226Idiopathic Parkinson's Disease (PD)

Fondazione Policlinico Universitario Campus Bio-Medico

Not applicable

Roma

2026-02-14

Recruiting

A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

NCT07210723Symptomatic Genetic Dilated Cardiomyopathy

DrugDanicamtiv

Kardigan, Inc.

Phase 2/3

332

Bari, Florence, Milan, Padova, Pavia, Roma, Rozzano, Trieste

2026-02-13

Recruiting

Phase 2 EL219 Versus Liposomal Amphotericin B or Voriconazole for Early Antifungal Therapy

NCT07215273Invasive Mould Infection

DrugVoriconazole

Elion Therapeutics, Inc.

Phase 2

Milan, Roma

2026-02-13

Recruiting

A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

NCT07202546HIV Infections

DrugsVH4524184·Dovato·Dolutegravir/Lamivudine

ViiV Healthcare

Phase 2

186

Bergamo, Milan, Roma

2026-02-11

Recruiting

A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

NCT07201922Familial Pulmonary Fibrosis, Interstitial Lung Abnormalities, Interstitial Lung Diseases

DrugNerandomilast

Boehringer Ingelheim

Phase 3

Milan, Padova, Roma

2026-02-10

Recruiting

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

NCT07215702Sepsis, Acute Kidney Injury

DrugAZD4144

AstraZeneca

Phase 2

124

Milan, Padua, Roma, Rozzano

2026-02-10

Recruiting

Cognitive and Physical Recovery After Hip Fracture in Frail Patients Using Digital Rehabilitation Technology

NCT07392515Fracture Femur, Hip Arthroplasty Replacement, Total Hip Arthroplasty (THA)

C.O.T. Cure Ortopediche Traumatologiche S.p.A.

Not applicable

Messina, Roma

2026-02-09

Active, closed

A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma

NCT07266441Multiple Myeloma

DrugRamantamig

Janssen Research & Development, LLC

Phase 2

168

Bergamo, Bologna, Cuneo, Florence, Palermo, Pavia, Pescara, Roma

2026-02-08

Recruiting

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

NCT07258511Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

400

Alessandria, Brescia, Milan, Pisa, Reggio Emilia, Roma, Rozzano, San Giovanni Rotondo

2026-02-04

Recruiting

Early Feasibility Clinical Investigation to Assess YntraDose™ as a Neoadjuvant Treatment for LA-PDAC

NCT07155850Pancreatic Ductal Adenocarcinoma (PDAC), Locally Advanced, Unresectable

BetaGlue Therapeutics SpA

Not applicable

Roma

2026-02-03

Recruiting

TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy

NCT07223203Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy, hATTR-PN

DrugsNucresiran·Vutrisiran

Alnylam Pharmaceuticals

Phase 3

125

Florence, Milan, Padova, Pavia, Roma

2026-02-03

Not yet open

Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas

NCT07394413Cervical Adenosarcoma

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Roma

2026-02-01

Not yet open

DELphi Procedure for Developing Recommendations for the Implementation of Wearable Devices and Polygenic Risk Scores

NCT07358481Wearable Electronic Devices, Polygenic Risk Score, CVD - Cardiovascular Disease, Primary Prevention

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-02

Not yet open

Cirrhotic and Non-cirrhotic Patients With Clinically Significant Portal Hypertension

NCT07405749Cirrhosis, Liver, Portal Hypertension, Clinically Significant Portal Hypertension(CSPH), Gastroesophageal Varices

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

2,500

Roma

2026-02

Recruiting

Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer

NCT07288177Non-small Cell Lung Cancer (NSCLC)

DrugRina-S

Genmab

Phase 2

240

Candiolo, Meldola, Orbassano, Ravenna, Roma

2026-01-30

Recruiting

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

NCT07227298Advanced/Metastatic Non-Small Cell Lung Cancer, Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Cancer

DrugsSigvotatug vedotin·PF-08634404

Pfizer

Phase 1/2

162

Fano, Roma

2026-01-30

Recruiting

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

NCT07227597Small Cell Lung Cancer Extensive Stage

DrugsGocatamig·Ifinatamab Deruxtecan·Etoposide·Atezolizumab

Merck Sharp & Dohme LLC

Phase 1/2

170

Meldola, Milan, Roma

2026-01-29

Recruiting

Upfront Targeted Axillary Dissection for Luminal Breast Cancer With Limited Axillary Involvement

NCT07278726ALND, Sentinel Lymph Node Biopsy (SLNB), Targeted Axillary Dissection (TAD)

European Institute of Oncology

Observational

150

Bologna, Forlì, Milan, Naples, Ortona, Pavia, Pisa, Roma

2026-01-28

Recruiting

A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia

NCT07277231Chronic Lymphocytic Leukemia

DrugsSonrotoclax·Venclyxto·Acalabrutinib·Venclexta

BeOne Medicines

Phase 3

500

Bologna, Florence, Milan, Padova, Roma

2026-01-22

Recruiting

UNMASK: Unveiling the Pathobiology of Metabolic Dysfunction-Associated Steatotic Liver Disease for the Discovery of Novel Therapeutics and Biomarkers

NCT07652151MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Not applicable

450

Roma

2026-01-20

Recruiting

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

NCT07216703Cervical Cancer

DrugsMvasi·Sacituzumab tirumotecan·Paraplatin·Avastin

Merck Sharp & Dohme LLC

Phase 3

1,023

Meldola, Aviano, Milan, Brescia, Catania, Padova, Roma, Torino

2026-01-19

Recruiting

Vorasidenib Maintenance for IDH Mutant Astrocytoma

NCT06809322IDH-mutant Grade 2 or 3 Astrocytoma

DrugVorasidenib

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

468

Bologna, Padova, Roma, Torino

2026-01-16

Recruiting

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

NCT07195695Non-small Cell Lung Cancer

DrugsZongertinib·Atezolizumab·Durvalumab·Nivolumab

Boehringer Ingelheim

Phase 3

400

Bari, Milan, Misterbianco (CT), Naples, Orbassano (TO), Roma, Rozzano (MI), Verona

2026-01-16

Not yet open

Framework for Optimizing, Refining, and Unifying Management of HSCT in Pediatric ALL

NCT07297914Acute Lymphoblastic Leukemia (ALL), Stem Cell Transplant, Graft -Versus-host-disease

DrugsBlinatumomab·Cyclophosphamide

Bambino Gesù Hospital and Research Institute

Phase 2/3

1,000

Roma

2026-01-15

Not yet open

SCUBE Proteins in Polycystic Ovary Syndrome (IPSOS)

NCT07396402Polycystic Ovary Syndrome (PCOS), Insulin Resistance

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2026-01-15

Recruiting

A First-in-Human Study of BMS-986506 in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

NCT07195682Renal Cell Carcinoma

DrugsPumitamig·Yervoy·Ipilimumab

Bristol-Myers Squibb

Phase 1

281

Roma, Verona

2026-01-15

Recruiting

Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

NCT07325292Multiple Sclerosis

DrugsMRI contrast-enhancing preparations·Frexalimab

Sanofi

Phase 3

160

Milan, Foggia, Roma

2026-01-14

Recruiting

A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma

NCT06980480Multiple Myeloma, Secondary Immunodeficiency

Takeda

Phase 3

183

Catania, Pavia, Pescara, Roma, Torrette

2026-01-14

Recruiting

Evaluation of the Effectiveness of an Educational Intervention in Splenectomized Patients

NCT07354893Splenectomized Patients, Splenectomy, Splenectomy; Status, Asplenia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Rome, Roma

2026-01-13

Recruiting

REAL-CARE: Real-world Effectiveness of Iptacopan in Italian Patients With Paroxysmal Nocturnal Hemoglobinuria

NCT07229235Paroxysmal Nocturnal Hemoglobinuria (PNH)

Novartis Pharmaceuticals

Observational

Alessandria, Avellino, Brescia, Florence, Genova, Milan, Palermo, Roma

2026-01-13

Recruiting

Bruxism Therapy of Facial Pain

NCT07611643Bruxism, Bruxism, Sleep-Related, Sleep Quality

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2026-01-12

Not yet open

Clinical and Imaging Features in MRKH Syndrome

NCT07321782Mayer Rokitansky Kuster Hauser Syndrome, Müllerian Agenesis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-01-12

Recruiting

Endoscopic Suture Gastroplasty (ESG) for Treatment of Obese Patients With Endometrial Cancer

NCT07397624Endometrial Cancer

Centro di Riferimento Oncologico - Aviano

Observational

Aviano, Roma

2026-01-08

Recruiting

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

NCT07179380Pulmonary Hypertension, Interstitial Lung Disease

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 3

344

Bologna, Catania, Milan, Modena, Monza, Naples, Pavia, Roma

2026-01-07

Recruiting

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT07222566Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)

DrugsPF-08634404·Pembrolizumab

Pfizer

Phase 3

1,410

Naples, Misterbianco, Meldola, Milan, Fano, Aviano, Roma, Brescia

2026-01-06

Recruiting

Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder

NCT07224581GRIN-related Neurodevelopmental Disorder

DrugRadiprodil

GRIN Therapeutics, Inc.

Phase 3

100

Florence, Pavia, Roma

2026-01-05

Recruiting

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

NCT07172919Advanced Solid Tumors

DrugsLumakras·Sotorasib·Panitumumab

Amgen

Phase 2

Roma

2026-01-02

Recruiting

Oral Health and Systemic Diseases: Survey of General Practitioners

NCT07604493Periodontal Disease, Diabete Mellitus

University of Roma La Sapienza

Observational

100

Roma

2026-01-01

Recruiting

Feeding Disorders in Children

NCT07431671Neurodevelopmental Disorder (Diagnosis), Feeding Disorder, ARFID

IRCCS San Raffaele Roma

Not applicable

Roma

2026-01-01

By invitation

COLORECTAL CANCER: SINGLE CENTER EXPERIENCE

NCT07576049Colorectal Cancer (Diagnosis)

University of Roma La Sapienza

Observational

Roma

2026-01-01

Recruiting

Reconstruction With a Lawrence-Hunt Jejunal Pouch After Total Gastrectomy

NCT06967571Total Gastrectomy, Gastric Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2026-01-01

Not yet open

Antithrombotic Therapy at the End of Life: The PEACE Study

NCT07338071Palliative Care

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

410

Roma

2026-01

Not yet open

Proteomic Changes in Patients With Myasthenia Gravis and Ravulizumab

NCT07337395Myasthenia Gravis Generalised

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2026-01

Not yet open

Cost-Effectiveness and Outcome of Robot-assisted Vs Laparoscopic Roux-en-Y Gastric Bypass

NCT07153419Morbid Obesity

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

512

Roma

2026-01

Active, closed

Comparing Advanced Hemostasis and Ultrasound-Guided Puncture to Conventional Approaches in Distal Radial Access

NCT06835829Coronary Catheterization

Associazione per lo Studio delle Malattie Cardiovascolari Cardiva ONLUS

Not applicable

480

Roma, Legnago

2025-12-31

Recruiting

Study to Assess the Safety and Tolerability of Tafasitamab in Adult Participants With Primary Autoimmune Blood Cell Disorders

NCT07104565Immune Thrombocytopenia

Incyte Corporation

Phase 2

Bologna, Brescia, Meldola, Milan, Naples, Padova, Roma

2025-12-29

Recruiting

A Study to Investigate Bowel Cleansing With PLENVU® Compared to Sodium Picosulfate in Participants Aged 1 to < 18 Years of Age in Preparation for Colonoscopy

NCT07218523Bowel Cleansing Prior to Clinical Procedures

DrugsPicoprep·Plenvu

Norgine

Phase 3

212

Bergamo, Florence, Messina, Milan, Naples, Roma

2025-12-29

Recruiting

Adjuvant Treatment in Premenopausal Breast Cancer

NCT06807749Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

800

Roma, Salerno

2025-12-24

Recruiting

Comparison of Bone Mineral Density in the Third Trimester Between Women in Singleton and Twin Pregnancies Using Questionnaires and REMS Densitometric Examination

NCT07508553Osteoporosis, Pregnancy, Twin Pregnancy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

100

Roma

2025-12-23

Recruiting

Microbiological and Biochemical Profiling of Amniotic Fluid in Women With Short Cervix or Premature Rupture of Membranes

NCT07792083Short Cervix, PROM, Preterm (Pregnancy)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

300

Roma

2025-12-23

Recruiting

AEF0217 in Participants With Down Syndrome

NCT07334912Down Syndrome (Trisomy 21)

Aelis Farma

Phase 2

188

Bologna, Roma, Troina

2025-12-22

Recruiting

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

NCT07225946Prostatic Neoplasms, Castration-Resistant

DrugsPasritamig·Prednisone/Prednisolone·Docetaxel

Janssen Research & Development, LLC

Phase 3

800

Florence, Localita La Schiana Pozzuoli, Milan, Roma, Torino

2025-12-19

Recruiting

Chemotherapy De-escalation in HR +, HER2-, Intermediate-risk Early Breast Cancer Treated With Adjuvant Ribociclib

NCT07237256Breast Cancer

UNICANCER

Phase 3

3,902

Aviano, Caserta, Genova, Naples, Padova, Pisa, Pontedera, Roma

2025-12-18

Recruiting

A Study on Hemolytic Disease of the Fetus and Newborn (HDFN) Through Global Registry

NCT07194070Hemolytic Disease of the Fetus and Newborn

Janssen Research & Development, LLC

Observational

175

Milan, Roma

2025-12-17

Recruiting

Gingival Phenotype and Dental Crowding in Pediatric Patients

NCT07205172Crowding, Tooth, Gingival Diseases

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

180

Roma

2025-12-16

Recruiting

A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

NCT07221474Squamous Non-small Cell Lung Cancer

DrugsIntismeran autogene·Nab-paclitaxel·Keytruda·Paclitaxel

Merck Sharp & Dohme LLC

Phase 2

180

Ravenna, Milan, Roma

2025-12-12

Recruiting

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

NCT07218380Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis

DrugsVepugratinib·Pembrolizumab

Eli Lilly and Company

Phase 3

450

Bari, Milan, Naples, Padova, Pisa, Roma, Rome

2025-12-12

Recruiting

An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

NCT07222267Breast Cancer, Advanced Solid Tumor

DrugBG-75202

BeOne Medicines

Phase 1

Milan, Naples, Roma, Rozzano

2025-12-11

Recruiting

A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia

NCT07144163Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 3

150

Genova, Milan, Rozzano, Modena, Padova, Palermo, Naples, Roma

2025-12-11

Recruiting

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

NCT07222800Intestinal Neoplasms, Gastrointestinal Neoplasms, Digestive System Neoplasms, Neoplasms by Site

DrugsPF-08634404·Avastin·Bevacizumab

Pfizer

Phase 3

800

Tricase, Roma, Padova, Florence, Milan

2025-12-11

Recruiting

Effect of a Food for Special Medical Purposes on Muscle Mass Preservation During GLP-1 RAs Weight Loss Treatment

NCT07393360Obesity & Overweight

Pharmanutra S.p.a.

Not applicable

144

Milan, Roma, Rozzano

2025-12-11

Recruiting

Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody

NCT07285213Clostridioides Difficile Infection

AstraZeneca

Phase 2

230

Modena, Naples, Palermo, Pisa, Roma, Varese

2025-12-10

Recruiting

Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer

NCT07226999Small Cell Lung Cancer (SCLC)

DrugsPF-08634404·Atezolizumab

Pfizer

Phase 2/3

550

Aviano, Roma, Orbassano

2025-12-09

Active, closed

Central Sensitization in Women With Adenomyosis: Prevalence, Risk Factors, and Therapeutic Failure

NCT07455721Adenomyosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,200

Bologna, Cagliari, Catanzaro, Florence, Milan, Palermo, Potenza, Roma

2025-12-09

Recruiting

A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

NCT07107945Chronic Kidney Disease

DrugDapagliflozin

Boehringer Ingelheim

Phase 3

120

Genova, Milan, Padova, Roma

2025-12-09

Recruiting

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

NCT07209111Neoplasm Malignant

DrugsCalderasib·Cetuximab

Merck Sharp & Dohme LLC

Phase 2

150

Rozzano, Milan, Roma

2025-12-04

Recruiting

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

NCT07276399Squamous Cell Carcinoma of Head and Neck

DrugsAmivantamab·Cisplatin·Carboplatin·Pembrolizumab

Janssen Research & Development, LLC

Phase 3

500

Milan, Naples, Palermo, Pavia, Roma, Rozzano

2025-12-03

Recruiting

A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis

NCT06979453Plaque Psoriasis

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

366

Rome, Roma

2025-12-03

Recruiting

Phase II Trial of Amivantamab Plus Monochemotherapy in Platinum Unfit NSCLC Patients With EGFR exon20 Insertion Mutations.

NCT07392658Metastatic NSCLC - Non-Small Cell Lung Cancer

DrugAmivantamab

Fondazione Ricerca Traslazionale

Phase 2

Roma

2025-12-02

Recruiting

Impact of Elexacaftor-Tezacaftor-Ivacaftor Treatment on Metabolic, Epigenetic and Fecal Microbiota Profiles in People With Cystic Fibrosis.

NCT07363304Cystic Fibrosis (CF)

DrugsTrikafta·Elexacaftor/Tezacaftor/Ivacaftor

Meyer Children's Hospital IRCCS

Observational

150

Bari, Milan, Naples, Roma, Torino, Florence

2025-12-02

Recruiting

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

NCT06937229Alzheimer Disease, Agitation

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

650

Naples, Rome, Milan, Pisa, Brescia, Isernia, Roma

2025-12-02

Not yet open

Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ

NCT06622421Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw, Osteonecrosis Due to Drug

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-12-01

Recruiting

New Diagnostic Criteria in the Evaluation Response to Ablation Treatment of Hepatocellular Carcinoma Nodules

NCT07272083Hepatocellular Carcinoma

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

200

Roma

2025-12-01

Recruiting

An Efficacy and Safety Study of DFL24498 in the Treatment of AKC

NCT07395232Atopic Keratoconjunctivitis

DrugDFL24498

Dompé Farmaceutici S.p.A

Phase 3

153

Bologna, Chieti, Florence, Roma, Verona

2025-12-01

Recruiting

Changes in Taste and Eating Habits Associated With GLP-1 Agonists in Weight Loss Patients

NCT07229170Obesity & Overweight, Taste Alterations, Weight Loss, Eating Behavior Changes

San Raffaele Telematic University

Observational

150

Roma, Rome

2025-12-01

Recruiting

A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

NCT07218146Small-cell Lung Cancer

DrugZL-1310

Zai Lab (Shanghai) Co., Ltd.

Phase 3

480

Ancona, Candiolo, Meldola, Ravenna, Roma, Verona

2025-11-30

Recruiting

A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs

NCT06930625Acromegaly

Debiopharm International SA

Phase 3

119

Ferrara, Genova, Milan, Naples, Padova, Roma, Torino

2025-11-26

Recruiting

A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer

NCT07155174Small Cell Lung Cancer

DrugsABBV-706·Lurbinectedin·Etoposide·Atezolizumab

AbbVie

Phase 2

180

Rome, Orbassano, Roma

2025-11-25

Recruiting

TrueLok Elevate PMCF Study

NCT07079774Wound of Skin, Ulcers, Soft Tissue Defect

Orthofix s.r.l.

Observational

153

Acquaviva delle Fonti, Parma, Roma, Tivoli, Palermo

2025-11-24

Recruiting

A Platform Study in Non-Small Cell Lung Cancer (NSCLC)

NCT06996782Advanced or Metastatic Non-small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Nab-paclitaxel·Pemetrexed

AstraZeneca

Phase 1/2

152

Milan, Orbassano, Pavia, Roma

2025-11-24

Recruiting

A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

NCT07227857Epileptic Encephalopathy

Institut de Recherches Internationales Servier

Phase 1/2

Florence, Roma

2025-11-24

Recruiting

Clinical Study in Adult and Young Adult Patients With Advanced Desmoplastic Small Round Cell Tumor (DSRCT) ISG-TULIPS

NCT07328425Desmoplastic Small Round Cell Tumor

DrugsLurbinectedin·Irinotecan

Italian Sarcoma Group

Phase 2

Candiolo, Milan, Padova, Prato, Roma

2025-11-21

Recruiting

Transition From Pediatric to Adult Care in Epilepsy

NCT07592676Epilepsy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-11-19

Active, closed

A Study to Learn About How Well BAY 3401016 Works in Adults With Alport Syndrome

NCT07211685Alport Syndrome

Bayer

Phase 2

Bologna, Brescia, Genova, Roma

2025-11-19

Recruiting

A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction

NCT07188805Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)

DrugFinerenone

Bayer

Phase 3

111

Bergamo, Bologna, Genova, Milan, Naples, Padova, Roma, Torino

2025-11-19

Recruiting

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

NCT07228832Metastatic Colorectal Cancer (CRC)

DrugsIvonescimab·Leucovorin·Adrucil·Oxaliplatin

Summit Therapeutics

Phase 3

600

Roma, Aviano, Brescia, Florence, Genova, Meldola, Milan, Pisa

2025-11-18

Recruiting

This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment

NCT07290803Atopic Dermatitis

Sanofi

Observational

1,000

Ancona, Novara, Reggio Emilia, Roma

2025-11-17

Recruiting

Youth Suicide Risk Factors, Reduction of Suicide Risk Factor in Youth People

NCT07188506Mood Disorders, Suicide, Attempted, Suicidal Ideation, Suicide Prevention

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

180

Roma

2025-11-15

Recruiting

Phase 3, Open Label Extension Study of ACP-204 in Lewy Body Dementia Psychosis

NCT07095465Lewy Body Dementia Psychosis

DrugACP-204

ACADIA Pharmaceuticals Inc.

Phase 3

126

Naples, Roma

2025-11-14

Recruiting

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis

NCT07219420Palmoplantar Pustulosis

DrugBimekizumab

UCB Biopharma SRL

Phase 3

320

Brescia, Roma, Rozzano

2025-11-14

Recruiting

Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

NCT07090005Obesity, Overweight

Nitinotes Surgical Ltd.

Not applicable

184

Roma

2025-11-14

Recruiting

A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to < 12 Years Old) With Nonsegmental Vitiligo

NCT06804811NonSegmental Vitiligo

DrugRuxolitinib

Incyte Corporation

Phase 3

250

Bologna, Brescia, Catania, Milan, Naples, Padua, Roma, Rome

2025-11-13

Active, closed

A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment

NCT07036523Idiopathic Pulmonary Fibrosis

Boehringer Ingelheim

Phase 2

Bergamo, Florence, Naples, Roma, Torino

2025-11-13

Recruiting

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

NCT07225504Secondary Progressive Multiple Sclerosis (SPMS)

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

1,275

Ancona, Bergamo, Foggia, Pozzilli, Pavia, Roma, Gallarate, Naples

2025-11-11

Recruiting

LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

NCT07186101Ulcerative Colitis

DrugsZotemtegrast·Mirikizumab

Eli Lilly and Company

Phase 2

252

Milan, Roma, Rozzano

2025-11-10

Recruiting

Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

NCT06990269Geographic Atrophy Secondary to Age-related Macular Degeneration

ADARx Pharmaceuticals, Inc.

Phase 2

240

Milan, Roma, Novara, Padova

2025-11-10

Recruiting

REal Word aPpLicAtion of Molecular Based Endometrial Cancer Classification

NCT07555665Endometrial Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

264

Roma

2025-11-07

Recruiting

A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

NCT07088926Bronchiectasis With Pseudomonas Aeruginosa Colonization

DrugAZD0292

AstraZeneca

Phase 2

435

Milan, Palermo, Pavia, Perugia, Roma, Rozzano, Torrette

2025-11-06

Recruiting

Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa

NCT07170917Hidradenitis Suppurativa

DrugBrivekimig

Sanofi

Phase 2

208

Milan, Catania, Roma

2025-11-06

Recruiting

A Phase II Trial to Evaluate the Clinical Efficacy, Safety and Tolerability of MAS825 in Pediatric and Adult Participants With Still's Disease

NCT07203001Still´s Disease

DrugArumakimig

Novartis Pharmaceuticals

Phase 2

Florence, Genova, Roma

2025-11-03

Active, closed

Design and Validation of Innovative Strategies Based on Dual-Task Approach

NCT07254377Stroke, Multiple Sclerosis, Parkinson Disease, Dual Task Exercises

I.R.C.C.S. Fondazione Santa Lucia

Not applicable

Roma

2025-11-01

Recruiting

Gentle Touch for Post-Mastectomy Lymphedema

NCT07257679Lymphedema, Breast Cancer

I.R.C.C.S. Fondazione Santa Lucia

Phase 4

Roma

2025-11-01

Active, closed

Point Prevalence Survey of Palliative Care Needs in Hospitals and Residential Care Facilities for the Elderly.

NCT07313748Palliative Care, Health Services

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

3,000

Roma

2025-11-01

Not yet open

Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With Anthracycline

NCT07253077Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity, Childhood Cancer Survivors

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-11

Recruiting

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

NCT07173751Breast Neoplasms

DrugsEribulin·Pumitamig·Gemcitabine·Carboplatin

BioNTech SE

Phase 3

558

Aviano, Lucca, Milan, Monza, Pisa, Roma, Torrette

2025-10-30

Recruiting

A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis

NCT07201051Bronchiectasis

DrugGSK3862995B

GlaxoSmithKline

Phase 2

363

Milan, Naples, Roma

2025-10-30

Recruiting

A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer

NCT07205822Breast Cancer

DrugDato-DXd

AstraZeneca

Phase 3

100

Aviano, Florence, Meldola, Milan, Naples, Roma

2025-10-30

By invitation

Clinical Trial of Vormatrigine in Adult Patients With Epilepsy

NCT07287163Epilepsy, Tonic-Clonic, Focal Seizure, Primary Generalized Seizure

Praxis Precision Medicines

Phase 3

700

Pozzilli, Bosisio Parini, Milan, Naples, Pavia, Pisa, Ponderano, Roma

2025-10-27

Recruiting

A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)

NCT06405087Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

Messina, Milan, Pescara, Roma

2025-10-27

Recruiting

Post Authorization Efficacy and Safety Study (PAES) to Confirm and Collect More Clinical Data of Buccalin® Tablets In the Prophylaxis of Recurrent Lower Respiratory Tract Infections (RLRTIs).

NCT06736288Respiratory Infection, Lower Respiratory Tract Infection (LRTI)

Laboratorio Farmaceutico SIT srl

Phase 4

240

Alessandria, Catania, Milan, Roma, Sassari

2025-10-21

Recruiting

Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.

NCT07407465Colorectal Cancer, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Rectal Cancer, Adenocarcinoma

DrugsTrastuzumab deruxtecan·Capecitabine·Bevacizumab

Gruppo Oncologico del Nord-Ovest

Phase 2

Bari, Florence, Milan, Ravenna, Rozzano, Tricase, Modena, Roma

2025-10-20

Recruiting

A Study of Efgartigimod IV in Participants From 12 Years to Less Than 18 Years of Age With Chronic Immune Thrombocytopenia (ITP)

NCT07194850Immune Thrombocytopenia (ITP), ITP - Immune Thrombocytopenia, ITP, Immune Thrombocytopenic Purpura

DrugEfgartigimod

argenx

Phase 2/3

Genoa, Monza, Roma, Torino

2025-10-20

Recruiting

Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency

NCT07266805Acquired Angioedema Due to C1-Inhibitor Deficiency (AAE-C1-INH)

DrugDeucrictibant

Pharvaris Netherlands B.V.

Phase 3

Milan, Padova, Roma

2025-10-16

Recruiting

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

NCT07165028Metabolic Dysfunction-Associated Steatotic Liver Disease

DrugsRetatrutide·Tirzepatide

Eli Lilly and Company

Phase 3

4,500

Bergamo, Bologna, Florence, Milan, Naples, Padova, Palermo, Roma

2025-10-15

Active, closed

A New Crowding Indicator in the Emergency Department

NCT07111624Emergency Department, Crowding

Mario Negri Institute for Pharmacological Research

Observational

828

Brescia, Genova, Ravenna, Roma, Cirié, Orbassano, Vercelli, Alessandria

2025-10-15

Recruiting

SUBDIMA: Subclinical Depression in Acute Myocardial Infarction (SUBDIMA25)

NCT07492537Acute Myocardial Infarction, Subclinical Depression

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

100

Roma

2025-10-14

Recruiting

EPIK-P4: A Phase II Single-arm Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (PROS)

NCT06997588PIK3CA-related Overgrowth Spectrum (PROS)

DrugAlpelisib

Novartis Pharmaceuticals

Phase 2

140

Roma, Torino, Trieste

2025-10-09

Active, closed

Comfortage - AD Prevention Strategies

NCT06896201Alzheimer Disease, Subjective Cognitive Impairment, Mild Cognitive Impairment

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

200

Roma

2025-10-07

Recruiting

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

NCT07196722Crohn Disease

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 2/3

1,092

Cagliari, Milan, Monza, Negrar-Verona, Roma, Rozzano, Torino

2025-10-03

Recruiting

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

NCT07181161Metastatic Prostate Cancer

DrugPalacaparib

AstraZeneca

Phase 1/2

283

Milan, Naples, Roma, Rozzano

2025-10-01

Recruiting

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

NCT07041099Sjögren, Sjogren Disease, Sjogren's Syndrome

DrugCLN-978

Cullinan Therapeutics Inc.

Phase 1

Roma

2025-10-01

Recruiting

HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

NCT05745714Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory

DrugsRuxolitinib·Cytarabine·Venetoclax·Dexamethasone

Princess Maxima Center for Pediatric Oncology

Phase 1/2

Genova, Monza, Padova, Roma, Turin

2025-10-01

Active, closed

IL-6 and Lactates in Cord Blood and Neonatal Outcomes

NCT07211503Fetal Infection, Fetal Inflammatory Response Syndrome, Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

160

Roma

2025-10-01

Recruiting

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

NCT07196748Colitis, Ulcerative

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

882

Bologna, Florence, Milan, Negrar-Verona, Roma, Rozzano, San Giovanni Rotondo

2025-10-01

Recruiting

HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

NCT05751044Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory

DrugsDasatinib·Cytarabine·Venetoclax·Dexamethasone

Princess Maxima Center for Pediatric Oncology

Phase 1/2

Genova, Monza, Padova, Roma, Turin

2025-10-01

Recruiting

#AWARE.HIV Europe: Supporting Healthcare Professionals to Find Undiagnosed HIV in European Hospitals: An Effectiveness-implementation Trial.

NCT06900829HIV Infection, HIV, Stigma, Education

Casper Rokx

Not applicable

5,200

Milan, Roma

2025-10-01

Recruiting

Hemodynamic Optimization Using an Artificial Intelligenze System

NCT07366164Hemodynamic (MAP) Stability, Fluid Management

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-10-01

Recruiting

An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy

NCT07197866Multiple System Atrophy

DrugEmrusolmin

Teva Branded Pharmaceutical Products R&D LLC

Phase 2

200

Bologna, Catania, Milan, Padova, Roma, Salerno

2025-09-30

Recruiting

Vitamin k, D-chiro Inositol and α-lactalbumin in Bone Homeostasis

NCT07256769Osteoporosis Secondary, Breast Cancer Females

Regina Elena Cancer Institute

Observational

134

Latina, Roma

2025-09-29

Recruiting

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

NCT07144280Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Carcinoma

DrugsPF-08046054·Docetaxel

Pfizer

Phase 3

680

Aviano, Rome, Roma, Florence, Verona, Bergamo, Caserta, Genova

2025-09-29

Recruiting

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

NCT07129993Urothelial Cancer, Bladder Cancer

DrugsDato-DXd·Gemcitabine·Cisplatin·Carboplatin

Daiichi Sankyo

Phase 2/3

630

Naples, Roma, Rozzano

2025-09-26

Recruiting

Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide

NCT07429864HBV, HBV Coinfection, HCV, HIV Infections

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-09-24

Recruiting

International Study of the SING IMT™ Prosthesis in Pseudophakic patiEnts With Stable Moderate to Profound Bilateral Central vIsion Impairment Due to adVancEd AMD / PERSPECTIVE Study

NCT07164378Age - Related Macular Degeneration (AMD)

VisionCare, Inc.

Not applicable

Bari, Bergamo, Ferrara, Florence, Roma

2025-09-23

Recruiting

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

NCT07111520Non-small Cell Lung Cancer

DrugsBNT326·Pumitamig

BioNTech SE

Phase 1/2

880

Alessandria, Catania, Florence, Milan, Roma

2025-09-22

Recruiting

Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

NCT07116967Plaque Psoriasis

DrugsUstekinumab·Deucravacitinib

Bristol-Myers Squibb

Phase 3

3,040

L’Aquila, Cagliari, Rozzano, Baggiovara, Bologna, Chieti, Naples, Roma

2025-09-22

Recruiting

Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

NCT07176689Desmoid Tumor, Aggressive Fibromatosis

DrugNirogacestat

SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Phase 4

Meldola, Candiolo, Bologna, Milan, Naples, Roma

2025-09-17

Not yet open

Sleep-Disordered Breathing in Children With Cerebral Palsy at Increased Risk of Respiratory Disorders

NCT07077226Sleep-disordered Breathing (SDB)

GUIDO CAMANNI

Observational

150

Padova, Assisi, Roma, Salerno, Trieste, Varese, Naples

2025-09-15

Active, closed

A Study to Test Whether Nerandomilast Helps People With Lung Fibrosis Related to Rheumatic Diseases

NCT06806592Interstitial Lung Diseases, Systemic Autoimmune Rheumatic Diseases Associated Interstitial Lung Diseases

DrugNerandomilast

Boehringer Ingelheim

Phase 3

413

Brescia, Florence, Milan, Padova, Pavia, Roma

2025-09-13

Recruiting

Local Treatment of Breast Pain Based on the Daily Use of a Topical Gel

NCT07257770Mastalgia

Lo.Li.Pharma s.r.l

Not applicable

Roma

2025-09-11

Recruiting

A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer

NCT06919965Non-Muscle Invasive Bladder Neoplasms

DrugsErdafitinib·Mitomycin C·Gemcitabine

Janssen Research & Development, LLC

Phase 3

220

Bergamo, Brescia, Genova, Milan, Naples, Roma, Sanatorio San Luigi, Udine

2025-09-10

Recruiting

Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study

NCT06928272Long COVID

DrugsPirfenidone·Upadacitinib

Douglas D. Fraser

Phase 3

348

Roma, Modena

2025-09-10

Active, closed

ABX Versus CHX in NSPT

NCT07520968Periodontal Disease, Periodontal Disease Stage 2, Periodontal Disease, AVDC Stage 3

University of Roma La Sapienza

Not applicable

Roma

2025-09-09

Recruiting

A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)

NCT07164443Metastatic Castration-resistant Prostatic Neoplasms

DrugsJNJ-87189401·Pasritamig

Janssen Research & Development, LLC

Phase 3

1,203

Foggia, Milan, Naples, Padova, Palermo, Roma, Rozzano, Torino

2025-09-02

Recruiting

Clinical Trial on Bowel Preparation Comparing Mannitol 100g to Plenvu Both in a Same Day Regimen (CLEARWAY)

NCT07465705Elective Colonoscopy

DrugMannitol

NTC srl

Phase 3

412

Carpi, Aviano, Negrar, Bologna, Brescia, Como, Milan, Roma

2025-09-02

Not yet open

Effect of Graminex on Infertility Related to Male Accessory Glands Inflammation

NCT06974175Male Infertility, Prostatitis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-09-01

Recruiting

Gummy Smile and Altered Passive Eruption Prevalence

NCT07548398Altered Passive Eruption of Teeth

University of Roma La Sapienza

Observational

100

Roma

2025-09-01

Recruiting

Prosthetic Modality and MBL

NCT07156110Bone Loss

Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo

Not applicable

Roma

2025-09-01

Recruiting

Impact of Liquid Biopsy on the Therapeutic Pathway for Lung Cancer: Advancing the Molecular Characterization of Patients With Advanced Lung Adenocarcinoma by Integrating Liquid Biopsy Into the Early Stages of the Diagnostic and Therapeutic Pathway

NCT07649629Advanced Non-small Cell Lung Cancer (NSCLC)

Regina Elena Cancer Institute

Observational

Roma

2025-09-01

Recruiting

Virtual Reality for Shoulder Rehabilitation

NCT06797492Shoulder Musculoskeletal Disorders

Fondazione Policlinico Universitario Campus Bio-Medico

Not applicable

Roma, Rome

2025-09-01

Not yet open

The SUNRISE Project is Dedicated to Enhancing Primary Cancer Prevention Among Adolescents in Europe by Leveraging Innovative Digital Tools and Methodologies. SmartCoach, Developed by Swiss Research Institute for Public Health and Addiction (ISGF), is a Mobile Phone-based Life-skills Training Program

NCT06922201Cancer

Biobizkaia Health Research Institute

Not applicable

3,500

Roma

2025-09

Not yet open

Clinical validatiOn of an AI-based DEcision Support System for Robotic Upper Limb Rehabilitation in Patients With Stroke. A CO-AIDER Study.

NCT07199322Stroke, Stroke Ischemic, Stroke Hemorrhagic, Upper Limb Rehabilitation

Fondazione Don Carlo Gnocchi ETS

Not applicable

100

Sant'Angelo dei Lombardi, Rovato, Florence, Tricarico, Pisa, Acerenza, Roma, La Spezia

2025-09

Not yet open

Technological Balance Rehabilitation in Feed and Eating Disorders

NCT06641973Feeding Disorders, Anorexia Nervosa, Bulimia Nervosa

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-09

Not yet open

HMB Supplementation and Motor Performance in Sarcopenic Patiens

NCT06801808Sarcopenia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-09

Not yet open

Low Powered Colorectal Anastomosis After Rectal Excision (OASIS)

NCT07146334Rectal Cancer, Surgery Indication

Bordeaux Colorectal Institute

Observational

400

Roma

2025-09

Not yet open

SUNRISE Aims to Create a Comprehensive, Engaging, and Sustainable Digital Health Promotion Program That Not Only Addresses Immediate Health Behaviours But Also Instils Lifelong Healthy Habits Among Adolescents. It is a Unique, Digitally Enhanced Program Combining Different Digital Solutions With New

NCT06931847Cancer

Biobizkaia Health Research Institute

Observational

4,000

Roma

2025-09

Not yet open

Evaluation of Dietary Supplementation in Patients With Gastrointestinal Disorders.

NCT06960941Irritable Bowel Syndrome, Metabolic Syndrome

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-09

Recruiting

A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)

NCT07200908Chronic Hepatitis D Infection

DrugBulevirtide

Mirum Pharmaceuticals, Inc.

Phase 3

172

Bergamo, Milan, Parma, Pisa, Roma

2025-08-27

Recruiting

A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP

NCT06920004Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy

DrugsEmpasiprubart·IVIG

argenx

Phase 3

218

Bologna, Pavia, Roma, Rozzano

2025-08-22

Recruiting

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine

NCT07018700Episodic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

990

Florence, Milan, Pavia, Roma

2025-08-21

Recruiting

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

NCT07018713Chronic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

780

Florence, Milan, Pavia, Roma

2025-08-21

Recruiting

2D-shear Wave Spleen Elastography in Clinically Significant Portal Hypertension and High-risk Varices

NCT07122622Portal Hypertension Related to Cirrhosis, Esophageal Varices

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

450

Roma

2025-08-20

Recruiting

A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer

NCT07005154Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer

DrugsPRL-02·Abiraterone acetate·Prednisolone·Prednisone

Astellas Pharma Global Development, Inc.

Phase 2

218

Milan, Roma, Trento

2025-08-19

Active, closed

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

NCT07005128Small-cell Lung Cancer, Extensive Stage Small-cell Lung Cancer

DrugsTarlatamab·Etoposide·Durvalumab·Carboplatin

Amgen

Phase 3

350

Bari, Bergamo, Meldola (FC), Milan, Roma, Verona

2025-08-18

Recruiting

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT07196501Major Depressive Disorder

DrugNBI-1065845

Neurocrine Biosciences

Phase 3

550

Milan, Roma, Rome, Torino

2025-08-18

Recruiting

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

NCT06887192Psychosis Associated With Alzheimer's Disease

DrugML-007C-MA

MapLight Therapeutics

Phase 2

300

Roma

2025-08-15

Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

NCT07070232Advanced Solid Tumor

DrugsBNT326·Paroxetine·Itraconazole·Pumitamig

BioNTech SE

Phase 1/2

1,438

Meldola, Milan, Naples, Roma, Rozzano

2025-08-12

By invitation

Transfemoral TAVI With or Without Coronary Angiogram in Patients With Severe Aortic Stenosis (PURE TAVI)

NCT06898086Severe Aortic Stenosis

Rede Optimus Hospitalar SA

Not applicable

620

Palermo, Pisa, Catania, Mestre, Roma, Siena, Trieste

2025-08-08

Recruiting

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

NCT07098338Non-Small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

278

Aviano, Catania, Meldola, Milan, Orbassano, Roma, Rozzano

2025-08-07

Recruiting

Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)

NCT06709339Polypoidal Choroidal Vasculopathy

DrugsVabysmo·Faricimab

Association for Innovation and Biomedical Research on Light and Image

Phase 4

120

Milan, Novara, Roma, San Raffaele, Udine

2025-08-06

Recruiting

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

NCT07029581Lewy Body Dementia Psychosis

DrugACP-204

ACADIA Pharmaceuticals Inc.

Phase 2

180

Naples, Salerno, Brescia, Roma

2025-08-06

Recruiting

Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy

NCT07075016Acute Myeloid Leukemia

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

227

Bologna, Milan, Roma, Torino

2025-08-05

Not yet open

A Single-center Prospective Interventional Study on FPG500 in Non-metastatic Prostate Cancer Patients

NCT06875297Prostate Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

184

Roma

2025-08-05

Recruiting

MELAFERT: Impact of Adjuvant Therapy on FERTility in Patients With Resected MELAnoma at High Risk of Relapse.

NCT07092670Melanoma, Fertility

DrugsDabrafenib·Trametinib·Nivolumab·Pembrolizumab

Intergruppo Melanoma Italiano

Observational

270

Bari, Genova, Milan, Modena, Naples, Padova, Perugia, Roma

2025-08-04

Recruiting

A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

NCT07005102Non-Squamous Non-Small Cell Lung Cancer, c-MET

DrugsTelisotuzumab Adizutecan·Osimertinib·Pemetrexed·Cisplatin

AbbVie

Phase 2/3

854

Rome, Orbassano, Perugia, Roma

2025-08-03

Recruiting

CACP: Study on Camptodactyly - Arthropathy - Coxa Vara - Pericarditis (CACP) Syndrome

NCT07468461Camptodactyly, Arthropathy, Coxa Vara, Pericarditis

Meyer Children's Hospital IRCCS

Observational

Bari, Florence, Genova, Milan, Padova, Roma, Udine

2025-08-01

Active, closed

Clinical Outcome of Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention in Patients With Severe Left Ventricular Disfunction (CROWN)

NCT07817524Coronary Artery Disease, Left Ventricular Cardiac Dysfunction

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

300

Roma

2025-08-01

Recruiting

A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia

NCT06721013Immune Thrombocytopenia (ITP)

DrugPirtobrutinib

Eli Lilly and Company

Phase 1/2

Bologna, Milan, Roma, Trieste

2025-07-30

Recruiting

A Study of Vosoritide Versus Placebo in Children With Hypochondroplasia Aged 0 to < 36 Months

NCT07126262Hypochondroplasia

DrugVosoritide

BioMarin Pharmaceutical

Phase 2

Roma, Genova

2025-07-30

Recruiting

O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock

NCT07107724Hemodynamic Instability, Oxygen Consumption (V̇O2)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-07-29

Recruiting

A Muscle-brain Interplay Study in Neurological Disorders

NCT07477821Neurological Disorders, Health Adult Subjects

Istituti Clinici Scientifici Maugeri SpA

Observational

150

Catania, Messina, Milan, Roma

2025-07-24

Recruiting

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

NCT06758401Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)

DrugsSigvotatug vedotin·Pembrolizumab

Pfizer

Phase 3

714

Naples, Misterbianco, Meldola, Pesaro (PU), Orbassano, Rome, Roma, Catania

2025-07-23

Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

NCT07060807Breast Neoplasms

DrugsPatritumab deruxtecan·Pegylated liposomal doxorubicin·Abraxane·Xeloda

Merck Sharp & Dohme LLC

Phase 3

1,000

Bergamo, Milan, Naples, Roma

2025-07-21

Recruiting

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

NCT06943755Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)

DrugsZanzalintinib·Everolimus

Exelixis

Phase 2/3

440

Aviano, Bologna, Meldola, Milan, Naples, Orbassano to, Palermo, Roma

2025-07-21

Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

NCT06976203Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

586

Naples, Foggia, Roma

2025-07-21

Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

NCT06765109Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive

DrugsNeladalkib·Alectinib

Nuvalent Inc.

Phase 3

450

Ancona, Bari, Meldola, Milan, Monza, Pisa, Ravenna, Roma

2025-07-17

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

NCT07011745Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

426

Naples, Rome, Milan, Pisa, Brescia, Isernia, Roma

2025-07-16

Active, closed

A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)

NCT07047118Prostatic Cancer, Castration-Resistant

DrugsLuxdegalutamide·Lu-PSMA

Novartis Pharmaceuticals

Phase 2

138

Genova, Roma

2025-07-03

Recruiting

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

NCT06863272Castration-Resistant Prostatic Cancer, Metastasis

DrugsOpevesostat·Ifinatamab Deruxtecan·Abiraterone·Enzalutamide

Merck Sharp & Dohme LLC

Phase 1/2

360

Orbassano, Brescia, Milan, Naples, Roma

2025-07-03

Recruiting

Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease

NCT06984484Gastroesophageal Reflux Disease (GERD)

Devintec Sagl

Not applicable

208

Genova, Milan, Naples, Padova, Roma, Rozzano (MI), Torino

2025-07-02

Recruiting

Implementation of Job Rotation for the Development of Nursing Competencies and the Improvement of Organizational Health in a Department of Cardiovascular Sciences: A Research Protocol

NCT06987487Healthy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-07-01

Recruiting

Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial

NCT07625995Traumatic Brain Injury, Severe Traumatic Brain Injury, Acute Brain Injury, Neurocritical Care

Erasme University Hospital

Phase 2

Genova, Roma

2025-07-01

Active, closed

A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

NCT06966453Breast Cancer, Breast Neoplasms

DrugDisitamab Vedotin

Pfizer

Phase 1/2

Naples, Meldola, Aviano, Livorno, Bologna, Roma

2025-06-30

Active, closed

Rezafungin for Treatment of Chronic Pulmonary Aspergillosis (CPA) in Adults With Limited Treatment Options

NCT06794554Chronic Pulmonary Aspergillosis

Mundipharma Research Limited

Phase 2

Genova, Pisa, Roma, Rozzano

2025-06-30

Recruiting

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

NCT07082738Chronic Obstructive Pulmonary Disease (COPD)

AstraZeneca

Phase 2

987

Busto Arsizio, Cuneo, Ferrara, Milan, Monza, Naples, Pavia, Roma

2025-06-27

Recruiting

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099Crohn's Disease, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

290

Bologna, Castellana Grotte, Milan, Padova, Pisa, Rho, Roma, Rozzano

2025-06-26

Recruiting

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

NCT06937086Ulcerative Colitis, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

350

Bologna, Castellana Grotte, Milan, Padova, Pisa, Rho, Roma, Rozzano

2025-06-26

Recruiting

Ultrasound Image Bank: Advancing Medical Research and Diagnostics

NCT07031921Gynecological Imaging, Ultrasound Diagnostics, Gynecologic Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

25,000

Roma

2025-06-25

Recruiting

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

NCT06846281Relapsing Multiple Sclerosis

DrugsRemibrutinib·Ocrelizumab

Novartis Pharmaceuticals

Phase 3

400

Bergamo, Foggia, Genova, Milan, Pavia, Roma

2025-06-23

Active, closed

Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

NCT06959225Hidradenitis Suppurativa

DrugRuxolitinib

Incyte Corporation

Phase 3

580

Catania, Cona, Florence, Milan, Naples, Roma, Rozzano, Torino

2025-06-23

Recruiting

Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

NCT06961214Pulmonary Disease, Chronic Obstructive

DrugDepemokimab

GlaxoSmithKline

Phase 3

961

Castelvenere, Foggia, Roma, Catania, Ferrara, Genova, Rozzano

2025-06-23

Recruiting

Surgical and Obstetric Outcomes in Endometrial Adenocarcinoma and Atypical Endometrial Hyperplasia With Conservative Treatment

NCT07077876Endometrial Adenocarcinoma, Endometrial Hyperplasia, Fertility Preservation, Conservative Treatment Therapy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Roma

2025-06-20

Active, closed

A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis

NCT06736990Idiopathic Pulmonary Fibrosis

Calluna Pharma AS

Phase 2

150

Padova, Roma, Siena, Trieste, Modena, Naples, Rozzano

2025-06-20

Not yet open

Ultrasound Training Program for Gynecologic Cancer Staging in Residents

NCT07028229Medical Education, Ovarian Cancer, Endometrial Cancer, Cervix Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-06-16

Not yet open

Minimally Invasive Interval Debulking Surgery in Advanced Ovarian Cancer

NCT07031908Ovarian Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-06-15

Recruiting

Primary Tumor Ablation and Outcome in Metastatic Renal Cell Carcinoma Treated With Immunotherapy Combinations.

NCT06903312Renal Cell Cancer, Kidney Neoplasm, Immunotherapy, Kidney Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase 4

409

Roma

2025-06-15

Recruiting

Study of Ravulizumab in Pediatric Participants With Primary IgAN

NCT07024563IgAN, IgAVN, Immunoglobulin A Nephropathy, Immunoglobulin A Vasculitis Associated Nephritis

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Phase 3

Genova, Roma, Torino

2025-06-14

Recruiting

A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

NCT06789913PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations, Vascular Malformations, PIK3CA Mutation

DrugRLY-2608

Relay Therapeutics, Inc.

Phase 2

277

Milan, Roma, Torino

2025-06-13

Not yet open

Ultrasound and Histology in AEH and Early EEC Treated Conservatively

NCT07028242Fertility-Sparing Treatment (FST), Atypical Endometrial Hyperplasia, Early Endometrial Cancer (EEC)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-06-11

Recruiting

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)

NCT06885034Gastrointestinal Neoplasms

DrugRisvutatug rezetecan

GlaxoSmithKline

Phase 1/2

451

Milan, Pisa, Roma

2025-06-11

Recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

NCT06340568Endometrial Cancer

DrugsDoxorubicin·Docetaxel·Paclitaxel

BioNTech SE

Phase 3

480

Bari, Bologna, Catania, Meldola, Milan, Naples, Roma, Torino

2025-06-10

Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

NCT07038200Facioscapulohumeral Muscular Dystrophy, FSHD, FSHD - Facioscapulohumeral Muscular Dystrophy, FSHD1

DrugDel-brax

Avidity Biosciences, Inc.

Phase 3

200

Milan, Pisa, Roma

2025-06-10

Active, closed

REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome

NCT06914609Angelman Syndrome

DrugObudanersen

Ionis Pharmaceuticals, Inc.

Phase 3

156

Milan, Pisa, Roma

2025-06-10

Active, closed

Study to Evaluate Tulisokibart for Hidradenitis Suppurativa (MK-7240-012)

NCT06956235Hidradenitis Suppurativa

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 2

149

Ancona, Milan, Roma

2025-06-09

Recruiting

Movement Improves Brain Health and Cognition in Parkinson's Disease

NCT07299279Parkinson Disease

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

150

Roma

2025-06-09

Recruiting

Implementing Polygenic Risk Scores for Breast Cancer Prevention: a Feasibility Study

NCT06922708Breast Cancer

Catholic University of the Sacred Heart

Not applicable

100

Roma

2025-06-06

Recruiting

High-frequency Ultrasound for Intraoperative Lymph Node Assessment in Gynecological Cancer: From Surgery to Radiomics

NCT06906705Gynecologic Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

160

Roma

2025-06-06

Recruiting

A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

NCT06872125Dravet Syndrome

DrugZorevunersen

Stoke Therapeutics, Inc

Phase 3

170

Florence, Genova, Roma

2025-06-04

Recruiting

Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study

NCT06935344Ovarian Cancer

Catholic University of the Sacred Heart

Observational

1,300

Roma

2025-06-01

Recruiting

A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE)

NCT06568627Venous Leg Ulcer (VLU)

DrugEscharEx

MediWound Ltd

Phase 3

216

Brindisi, Naples, Genoa, Pisa, Padova, Roma

2025-06-01

Recruiting

Personalised HeartCare: Poligenic Risk Scores Disclosure for Cardiovascular Prevention

NCT06888466Cardiovascular Diseases

Catholic University of the Sacred Heart

Not applicable

650

Roma

2025-06-01

Recruiting

Integration of Clinical, Biological and Psycho-social Variables for a Gender-sensitive Frailty Prediction

NCT07109596Aging Frailty

University of Roma La Sapienza

Observational

1,000

Roma

2025-06-01

Not yet open

MRI-Based Assessment of Local Anesthetic Spread in the PENG Block Compartment

NCT07040423Total Hip Arthroplasty (THA), Postoperative Pain Management After Total Hip Arthroplasty

Campus Bio-Medico University

Not applicable

Roma

2025-06

Recruiting

Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

NCT06784752Somatostatin Receptor Positive (SSTR+), Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)

DrugOctreotide LAR

Novartis Pharmaceuticals

Phase 3

240

Cona, Genova, Milan, Rozzano, Pisa, Roma

2025-05-30

Recruiting

Identification of New Theranostic Biomarkers of Pancreatic Tumor Progression

NCT06574373IPMN, Pancreatic

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

3,600

Roma, Rome

2025-05-29

Recruiting

A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

NCT06961006Malignant Melanoma

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 2

160

Milan, Naples, Padova, Roma

2025-05-29

Recruiting

High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project

NCT06822231Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)

Istituti Clinici Scientifici Maugeri SpA

Not applicable

124

Bari, Genova, Milan, Modena, Montescano, Pavia, Roma, Telese Terme

2025-05-28

Active, closed

A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

NCT06782373VEXAS, VEXAS Syndrome

DrugPacritinib

Swedish Orphan Biovitrum

Phase 2

156

Milan, Padova, Reggio Emilia, Roma

2025-05-28

Recruiting

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

NCT06780098Lung Neoplasm

DrugsR-DXd·Ifinatamab Deruxtecan·Taxotere·Docetaxel

Merck Sharp & Dohme LLC

Phase 2

144

Florence, Milan, Roma

2025-05-28

Recruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

NCT06941272Malignant Neoplasm

DrugPatritumab deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

Milan, Roma, Torino

2025-05-26

Recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

NCT06952504Endometrial Cancer

DrugsSacituzumab tirumotecan·Docetaxel·Keytruda·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

1,123

Meldola, Milan, Catania, Florence, Naples, Pisa, Roma, Torino

2025-05-22

Active, closed

A Long-term Study to Monitor the Health Status of People With Cystic Fibrosis Who Took Part in a Previous Study With BI 3720931 (Lenticlair™-ON)

NCT06962852Cystic Fibrosis

Boehringer Ingelheim

Phase 1/2

Roma

2025-05-20

Recruiting

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

NCT06935370Heart Failure

DrugsVicadrostat·Dapagliflozin

Boehringer Ingelheim

Phase 3

4,200

Bergamo, Naples, Pavia, Pisa, Roma, Rozzano

2025-05-20

Recruiting

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

NCT06990867Acute Ischemic Stroke

Corxel Pharmaceuticals

Phase 2/3

740

Pavia, Roma

2025-05-15

Recruiting

Surgical vs Transcatheter Aortic Valve Replacement in YOUNG Patients

NCT06861361Symptomatic Severe Aortic Stenosis

Ceric Sàrl

Not applicable

1,180

Mercogliano, Milan, Parma, Roma, San Donato Milanese

2025-05-15

Recruiting

Perioperative Durvalumab With Neoadjuvant ddMVAC in Patients With Muscle-Invasive Bladder Cancer (NIAGARA-2)

NCT06960577Urinary Bladder Neoplasms, Immune Checkpoint Inhibitors, Methotrexate, Vinblastine

DrugsVinblastine·Methotrexate·Doxorubicin·Durvalumab

AstraZeneca

Phase 2

150

Florence, Orbassano, Roma

2025-05-15

Recruiting

A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis

NCT07724990Ulcerative Colitis, Crohn Disease

Catholic University of the Sacred Heart

Not applicable

Roma

2025-05-14

Recruiting

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

NCT06780085Carcinoma, Non-Small-Cell Lung

DrugsR-DXd·Ifinatamab Deruxtecan

Merck Sharp & Dohme LLC

Phase 2

Milan, Florence, Roma

2025-05-13

Recruiting

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

NCT06563895Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies

DrugAcoramidis

Eidos Therapeutics, a BridgeBio company

Phase 3

587

Bologna, Florence, Pavia, Pisa, Roma, Rome

2025-05-12

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

NCT06925750Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

130

Milan, Verona, Bologna, Genova, Pavia, Roma, Sassari

2025-05-12

Recruiting

Burden of Cytomegalovirus Reactivation in Pediatric Patients After Allogeneic Hematopoietic Stem Cell Transplantation

NCT06916195Cytomegalovirus Infection, Hematopoietic Stem Cells Transplantation

MSD Italia S.r.l.

Observational

230

Genova, Monza, Padova, Roma, Torino

2025-05-09

Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

NCT06921785Hepatocellular Carcinoma

DrugsRilvegostomig·Tremelimumab·Atezolizumab·Bevacizumab

AstraZeneca

Phase 3

1,220

Bologna, Milan, Palermo, Perugia, Pisa, Roma, Rozzano

2025-05-06

Recruiting

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

NCT06881784NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer, NSCLC, NSCLC (Non-small Cell Lung Carcinoma)

DrugsCetuximab·Docetaxel

Revolution Medicines, Inc.

Phase 3

590

Milan, Rossano, Monza, Naples, Pisa, Roma, Rome

2025-05-06

Recruiting

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

NCT06892548Advanced Lung Cancer

DrugsBNT324·Pumitamig

BioNTech SE

Phase 1/2

594

Candiolo, Milan, Naples, Roma, Verona

2025-05-02

Recruiting

Ultrasound Transformation of Myomas During Relugolix-Estradiol-Norethisterone Treatment: The MySaturn Study

NCT06953076Uterine Bleeding, Uterine Leiomyomas, Uterine Hemorrhage, Uterine Neoplasms

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

111

Roma

2025-05-02

Not yet open

Face Mask vs Laryngeal Mask in Neonatal Resuscitation

NCT06952088Neonatal Complication, Neonatal Asphyxia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

150

Roma

2025-05-01

Recruiting

No-Stoma Policy in Advanced Ovarian Cancer Surgery

NCT07213193Ovary Cancer

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

395

Roma

2025-05-01

Recruiting

Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis

NCT06859866Peri-implant Mucositis

Koite Health Oy

Not applicable

Roma

2025-04-29

Recruiting

High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project

NCT06881979Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease

Istituti Clinici Scientifici Maugeri SpA

Not applicable

Genova, Milan, Modena, Montescano, Pavia, Roma, Telese Terme

2025-04-28

Active, closed

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

NCT06914895Type 1 Diabetes, Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

905

Bologna, Catanzaro, Florence, Milan, Naples, Padova, Roma, Torino

2025-04-25

Recruiting

A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer

NCT06827236Locally Advanced Breast Cancer, Unresectable Breast Carcinoma, Metastatic Breast Cancer

DrugPumitamig

BioNTech SE

Phase 1/2

380

Bologna, Genova, Milan, Naples, Roma

2025-04-23

Recruiting

Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

NCT06965023ST-elevation Myocardial Infarction (STEMI), Microplastics, Nanoplastics, Pollution Exposure

Azienda Ospedaliera "Sant'Andrea"

Observational

130

Roma, Caserta, Catania, Ferrara, Forlì, Milan, Naples, Turin

2025-04-22

Recruiting

Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.

NCT06919757Intrauterine Growth Retardation (IUGR), Lung Function Tests, Preterm Infant, Respiratory Monitoring

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-04-20

Recruiting

A Randomized Phase II Trial of Cemiplimab Plus OSE2101 ( TEDOPI®) as Maintenance Therapy in ctDNA Positive NSCL. The Cemited Study.

NCT07264673NSCLC

DrugsTedopi·Cemiplimab

Fondazione Ricerca Traslazionale

Phase 2

160

Roma

2025-04-17

Recruiting

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT06966401Major Depressive Disorder

DrugNBI-1065845

Neurocrine Biosciences

Phase 3

850

Roma

2025-04-16

Active, closed

Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)

NCT06814145Hypertension, Pulmonary

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

440

Bergamo, Pavia, Roma

2025-04-16

Recruiting

OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT)

NCT06462963Breast Cancer, Prostate Cancer, NSCLC, Colorectal Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Not applicable

302

Florence, Milan, Negrar, Roma, Torino

2025-04-15

Recruiting

A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

NCT06846671CLL, Chronic Lymphocytic Leukemia

DrugsIdelalisib·Tacabrutideg·Bendamustine·Venetoclax

BeOne Medicines

Phase 3

250

Bari, Florence, Milan, Naples, Novara, Pavia, Perugia, Roma

2025-04-10

Recruiting

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

NCT06824467Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

DrugsSteroid mouthwash (dexamethasone·Mvasi·Acetaminophen·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

770

Aviano, Milan, Pisa, Bari, Brescia, Naples, Padova, Roma

2025-04-09

Active, closed

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

NCT06822790Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

710

Rozzano, Bologna, Brescia, Milan, Palermo, Roma

2025-04-09

Active, closed

Microbiota in Children With Severe Burn Injury

NCT07098377Burn

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-04-07

Recruiting

Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

NCT06801834Extensive Stage Small Cell Lung Cancer (ES-SCLC)

DrugsAmrubicin·Lurbinectedin·Topotecan·Sacituzumab Govitecan

Gilead Sciences

Phase 3

695

Aviano, Candiolo, Lucca, Milan, Naples, Pesaro, Peschiera del Garda, Roma

2025-04-04

Recruiting

Application of da Vinci SP for Endometrial Cancer Surgical Staging

NCT07027046Endometrial Cancer

National Cancer Institute, Naples

Observational

564

Naples, Milan, Roma

2025-04-03

Active, closed

A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis

NCT06863961Atopic Dermatitis

DrugAfimkibart

Hoffmann-La Roche

Phase 2

162

Roma, Milan, Catania, Ancona

2025-04-01

Not yet open

Mild Fetal Hydronephrosis, Gestational Diabetes and Spontaneous Resolution vs Moderate-severe Fetal Hydronephrosis, Obstructive Causes and Worse Postnatal Outcome

NCT06896149Hydronephrosis, Gestational Diabetes

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

800

Roma

2025-04-01

Recruiting

EMG Control Assistance Virtual Reality Interface Coupled With Cerebellar-iTBS for Arm Recovery After Stroke (ERICA)

NCT06911671Stroke, Stroke, Cardiovascular

I.R.C.C.S. Fondazione Santa Lucia

Not applicable

Roma

2025-04-01

Recruiting

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

NCT06731907Non-small Cell Lung Cancer

DrugsPatritumab deruxtecan·Abraxane·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 2

Milan, Roma

2025-03-30

Recruiting

Perception of Quality of Life in Patients Undergoing Endoscopic Vertical Gastroplasty

NCT06839677Obesity

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-03-28

Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

NCT06989112Endometrial Cancer

DrugsRilvegostomig·Taxotere·Paraplatin·Trastuzumab deruxtecan

AstraZeneca

Phase 3

600

Catania, Florence, Milan, Monza, Naples, Reggio Emilia, Roma, Rome

2025-03-27

Recruiting

Pilot Study for the Generation of Cervical Cancer Organoids From Patients Undergoing Diagnostic Biopsy

NCT07248878Cervical Cancer Stage IB2, Cervical Cancer Stage IIa, Cervical Cancer Stage IB, Cervical Cancer Stage IIIA

Regina Elena Cancer Institute

Observational

Roma

2025-03-26

Recruiting

Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

NCT06932263Asthma

DrugTozorakimab

AstraZeneca

Phase 2

540

Catania, Foggia, Genoa, Roma

2025-03-26

Recruiting

CeraVe Effect on Restoring Skin Hydration as Maintenance Regimen in Subjects With Mild to Moderate Atopic Dermatitis

NCT07204561Atopic Dermatitis (AD)

Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse

Not applicable

Roma

2025-03-25

Recruiting

Generation of Endometrial Carcinoma Organoids

NCT07258186Endometrial Cancer

Regina Elena Cancer Institute

Observational

Roma

2025-03-23

Recruiting

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

NCT06914128MTAP-deleted Solid Tumors

Bayer

Phase 1/2

450

Aviano, Milan, Roma, Rozzano

2025-03-21

Active, closed

Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)

NCT06788912Lung Neoplasm Malignant

DrugsSteroid mouthwash (dexamethasone·Acetaminophen·Ribociclib·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 2

Florence, Milan, Roma

2025-03-20

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

NCT06883305Chronic Obstructive Pulmonary Disease (COPD)

DrugTezepelumab

AstraZeneca

Phase 3

990

Cona, Florence, Milan, Montebelluna, Naples, Pavia, Roma, Sassari

2025-03-18

Recruiting

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT07032662Chronic Inflammatory Demyelinating Polyneuropathy

Immunovant Sciences GmbH

Phase 2

162

Bergamo, Bologna, Brescia, Milan, Pavia, Pisa, Roma, Siena

2025-03-18

Active, closed

Cognitive Functions in Severe Acquired Brain Injury After Cranioplasty

NCT06895109Brain Injury, Neuropsychological Deficits, Cranioplasty, Cognitive Deficit Following Brain Lesions

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-03-18

Recruiting

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

NCT06376162Relapsed/Refractory KMT2A-r Acute Leukemia, Relapsed/Refractory NUP98-r Acute Leukemia, Relapsed/Refractory NPM1-m Acute Leukemia

DrugsZiftomenib·Cytarabine·Fludarabine

PedAL BCU, LLC

Phase 1

Roma, Monza

2025-03-18

Active, closed

Evaluation of Essential Metal Metabolism

NCT06911515Disturbance of Consciousness, Alteration of Metabolism, Essential Metals

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

120

Roma

2025-03-17

Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT06841354Triple Negative Breast Neoplasms

DrugsAbraxane·Sacituzumab tirumotecan·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,000

Rome, Bologna, Genova, Milan, Novara, Padova, Roma

2025-03-16

Recruiting

Mitral Valve Annulus Assessment, Multimodality Imaging

NCT06797687Mitral Regurgitation

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-03-15

Recruiting

Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

NCT06873685Sarcoma, Soft Tissue

Fondazione Policlinico Universitario Campus Bio-Medico

Not applicable

120

Rome, Roma, Naples

2025-03-13

Active, closed

Early Myofascial Manual Treatment in Subjects With Spasticity Following Acquired Brain Injury

NCT06898242Brain Injury, Brain Injury, Vascular, Brain Injuries, Traumatic

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-03-13

Recruiting

L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

NCT06788756Acute Myeloid Leukaemia (AML)

DrugCytarabine

Moleculin Biotech, Inc.

Phase 2/3

312

Bologna, Florence, Ravenna, Roma

2025-03-12

Recruiting

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

NCT06792695Metastatic Colorectal Cancer

DrugsFOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)·Volrustomig·Bevacizumab

AstraZeneca

Phase 2

Bologna, Castelfranco Veneto, Florence, Milan, Naples, Pavia, Pisa, Roma

2025-03-12

Active, closed

Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

NCT06858839Obesity

DrugMaridebart cafraglutide

Amgen

Phase 3

3,853

Bologna, Chieti, Florence, Milan, Palermo, Pisa, Roma

2025-03-12

Recruiting

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

NCT06641466Menstrual Migraine

DrugRimegepant

Pfizer

Phase 3

723

Avezzano, Rome, Bologna, Florence, Milan, Pavia, Roma

2025-03-11

Recruiting

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

NCT06833073Urinary Bladder Neoplasms, Non-Muscle Invasive Bladder Neoplasms, Carcinoma in Situ

DrugIntismeran autogene

Merck Sharp & Dohme LLC

Phase 2

308

Milan, Rome, Arezzo, Roma

2025-03-11

Recruiting

Real-World Mapping Antithrombotic Regimens in MM Patients on Treatment

NCT06028087Multiple Myeloma, Diagnosis

Gruppo Italiano Malattie EMatologiche dell'Adulto

Observational

736

Roma

2025-03-10

Recruiting

Atezolizumab and Chemotherapy Treatment as T-cell Activators in Metastatic Triple Negative Breast Cancer Patients

NCT06690840Triple Negative Breast Cancer

DrugAtezolizumab

European Institute of Oncology

Phase 2

Monza, Roma, Brindisi, Milan

2025-03-06

Recruiting

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

NCT06796907Tumours, Gynecological

DrugsMo-Rez·Dostarlimab·Bevacizumab

GlaxoSmithKline

Phase 1/2

305

Milan, Roma, Naples

2025-03-04

Recruiting

Identification of a Score for the Assessment of Intrapancreatic Fat

NCT07155473Pancreatic Steatosis, Metabolic Syndrome X, Diabetes

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

100

Roma

2025-03-01

Recruiting

Multicenter Randomised Prospective Study for External Support Mesh VEST of Venous Coronary Grafts on the Right Territory

NCT06877195Ischemic Cardiovascular Disease

Cardiochirurgia E.H.

Not applicable

300

Roma

2025-03-01

Recruiting

Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke

NCT06297863Acute Ischemic Stroke

University of Milano Bicocca

Phase 2

118

Avezzano, Florence, Messina, Monza, Roma, Udine

2025-03-01

By invitation

Observational Study on Thyroid Tumors and EvaLuation of the roLe of New pOntential Predictive/Prognostic Factors

NCT07064369Carcinoma of Head/Neck

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

100

Roma

2025-02-28

Recruiting

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

NCT06517875Primary Myelofibrosis, Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

DrugsMomelotinib·Reblozyl·Luspatercept

GlaxoSmithKline

Phase 2

Bologna, Catania, Florence, Meldola FC, Milan, Roma

2025-02-28

Active, closed

Efficacy of Cosmetic Product RV3278B-OS0386 in the Maintenance Phase After Oral Isotretinoin Treatment of Adults Subjects With Facial Acne.

NCT07341659Acne

Pierre Fabre Dermo Cosmetique

Not applicable

102

Milan, Roma

2025-02-28

Recruiting

Tensi+ European Registry

NCT07205445Overactive Bladder

Stimuli Technology

Observational

500

Avellino, Florence, Modena, Montevarchi, Roma

2025-02-27

Recruiting

IMPACT-AML: A Randomized Pragmatic Clinical Trial for Relapsed or Refractory Acute Myeloid Leukemia.

NCT06713837Acute Myeloid Leukemia, Relapse/Recurrence

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Phase 3

339

Bologna, Genova, Palermo, Pescara, Perugia, Ravenna, Roma, Torino

2025-02-27

Active, closed

A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects With SCLC

NCT06745323Small Cell Lung Cancer (SCLC)

DrugTarlatamab

Amgen

Phase 2

252

Roma

2025-02-26

Recruiting

An Extension Study to Evaluate Safety and Efficacy of Atumelnant in Participants With Congenital Adrenal Hyperplasia

NCT06712823Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 2

200

Roma

2025-02-25

Recruiting

Patient Blood Management in Patients Scheduled for Cardiac Surgery

NCT06637137Anemia, Anemia, Iron-Deficiency, Iron Deficiency Anemia Treatment, Iron Deficiency Anemia (IDA)

DrugIron

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

464

Roma

2025-02-24

Recruiting

Frequency of FCGR3A Gene Polymorphisms in Patients With Neuromyelitis Optica Spectrum Disorders, Anti-oligodendrocyte Myelin Protein Antibody Disease, and Multiple Sclerosis.

NCT06865274Neuromyelitis Optica Spectrum Disorders, MOGAD, Multiple Sclerosis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma

2025-02-20

Recruiting

Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)≥1≤19.

NCT06869473Head and Neck Squamous Cell Carcinoma (HNSCC), Recurrent Head and Neck Cancer, Metastatic Head and Neck Cancer

Gruppo Oncologico del Nord-Ovest

Phase 2

Cagliari, Catania, Florence, Milan, Rozzano, Naples, Roma

2025-02-20

Recruiting

A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer

NCT06567782Neoplasms, Colon

DrugsCapeox·Dostarlimab

GlaxoSmithKline

Phase 2

120

Milan, Roma, Udine

2025-02-18

Recruiting

Feasibility Study of the FARAFLEX Mapping and PFA System

NCT06510556Atrial Fibrillation, Persistent Atrial Fibrillation, Paroxysmal AF

Boston Scientific Corporation

Not applicable

250

Roma

2025-02-17

Recruiting

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

NCT06760819Advanced Solid Tumors, HER2 Mutation

DrugSevabertinib

Bayer

Phase 2

111

Milan, Reggio Emilia, Roma

2025-02-13

Active, closed

Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer

NCT06619236Platinum-resistant Ovarian Cancer

DrugsRina-S·Pegylated liposomal doxorubicin·Topotecan·Gemcitabine

Genmab

Phase 3

584

Brindisi, Milan, Ponderano, Roma, Torino

2025-02-07

Recruiting

A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

NCT06624670Pyoderma Gangrenosum

DrugsSpesolimab·Prednisolone·Prednisone

LEO Pharma

Phase 3

Milan, Pisa, Roma, Rozzano (MI), Torino

2025-02-05

Recruiting

Balance in the Strabismic Patient Undergoing Strabismus Surgery

NCT06733220Strabismus

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

Roma

2025-02-05

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

NCT06618287Lung Cancer, Breast Cancer

DrugsPumitamig·Iza-bren·Osimertinib·Opdivo

Bristol-Myers Squibb

Phase 1/2

416

Aviano, Milan, Candiolo, Florence, Roma

2025-02-04

Recruiting

Evaluation of Stigma Toward Patients With Alopecia Areata, Atopic Dermatitis, Vitiligo, and Psoriasis

NCT06801821Psoriasis (PsO), Vitiligo Vulgaris, Atopic Dermatitis, Areata Alopecia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

400

Roma

2025-02-01

By invitation

Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE

NCT06679881Hereditary Angioedema (HAE)

DrugDeucrictibant

Pharvaris Netherlands B.V.

Phase 3

170

Milan, Padova, Palermo, Roma

2025-02-01

Recruiting

OM 85 to Prevent Respiratory Infections in Older At Risk Patients

NCT06655272Respiratory Tract Infections (RTI)

DrugBacterial Lysate

Campus Bio-Medico University

Phase 4

360

Roma

2025-02-01

Recruiting

A Prospective Randomised Study of Treatment Selection Based on Epigenetic Markers Versus Standard of Care Treatment Selection in Adults With CROHN's Disease

NCT07363044Crohn Disease (CD)

Alimentiv Inc.

Not applicable

378

Castellana Grotte, Florence, Milan, Roma, Rome, San Giovanni Rotondo

2025-02-01

Active, closed

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

NCT06710132Solid Tumors, Gastric Cancer, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Cancer

DrugM9140

EMD Serono Research & Development Institute, Inc.

Phase 1/2

184

Rome, Ancona, Milan, Naples, Padova, Pisa, Reggio Emilia, Roma

2025-01-29

Recruiting

Advantages and Disadvantages of TOXCLEAN As Add on Treatment to SOC in Patients with Clostridium Difficile-associated Diarrhea

NCT06839209Clostridium; Difficile, As Cause of Disease Classified Elsewhere, Clostridium Difficile Diarrhea

ABResearch S.r.l.

Not applicable

Roma

2025-01-27

Recruiting

NEOadjuvant Abemaciclib and GIredestrant TriaL in Patients with ER-positive, HER2-negative Early Breast Cancer

NCT06259929Breast Cancer

DrugsGiredestrant·Abemaciclib

Fondazione Oncotech

Phase 2

Catania, Genova, Naples, Padova, Aviano, Roma

2025-01-27

Active, closed

Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation

NCT06551649Amyotrophic Lateral Sclerosis, Multiple Sclerosis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

Roma, Rome

2025-01-17

Recruiting

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

NCT06555419Muscular Atrophy, Spinal

DrugNusinersen

Biogen

Phase 1

Milan, Roma

2025-01-16

By invitation

Charles Bonnet Syndrome in Low Vision Patients

NCT07563101Charles Bonnet Syndrome

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

640

Roma

2025-01-15

Active, closed

Progressive Advancements in Neurosurgery, Data and Analysis Database

NCT06835634Spine Disease, Central Nervous System Diseases, Peripheral Nervous System Diseases

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

7,500

Roma

2025-01-15

Recruiting

Spatiotemporal Entrainment Neuromodulation Targeting Cerebello-Cerebral Circuits to Enhance Cognitive and Social Rehabilitation in Cerebellar Diseases

NCT07500103Cerebellar Degeneration, Cerebellar Malformation

I.R.C.C.S. Fondazione Santa Lucia

Not applicable

Pavia, Roma

2025-01-15

Active, closed

A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome

NCT06684847Primary Sjogrens Disease

DrugEfgartigimod PH20

argenx

Phase 3

631

Brescia, Pisa, Roma

2025-01-15

Recruiting

Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases

NCT06529913Allergic Contact Dermatitis, Metal Allergy, Food Allergy, Nickel Sensitivity

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

280

Bologna, Roma

2025-01-13

Recruiting

MIRAMACS, Multicenter Italian Study on RAdial Mechanically Assisted Circulatory Support

NCT07458074Heart Failure

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

400

Bergamo, Bologna, Genova, Milan, Padova, Palermo, Pavia, Roma

2025-01-10

Recruiting

New Stereophotogrammetry System to Capture Complete-arch Impression

NCT06745232Prosthetic Complication, Prosthesis Failure, Dental

University of Rome Tor Vergata

Observational

Roma

2025-01-10

Recruiting

A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD

NCT06659549Geographic Atrophy of the Macula

Galimedix Therapeutics Inc

Phase 2

110

Milan, Roma

2025-01-10

Active, closed

Assessment of Self-Care in Patients With Idiopathic Pulmonary Fibrosis (IPF)

NCT07139925IPF

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

156

Roma

2025-01-09

Recruiting

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

NCT06807424Arthritis, Psoriatic

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

750

Ancona, Brescia, Catania, Milan, Naples, Pavia, Roma, Rozzano

2025-01-09

Recruiting

International Care Bundle Evaluation in Cerebral Hemorrhage Research

NCT06429332Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke

Region Skane

Phase 4

3,500

Avezzano, Città di Castello, Gubbio, Perugia, Roma

2025-01-07

Active, closed

Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease

NCT06760637Breast Cancer

DrugsAtirmociclib·Abemaciclib·Ribociclib·Palbociclib

Pfizer

Phase 3

1,035

Bologna, Meldola(FC), Rome, Florence, Milan, Novara, Padova, Roma

2025-01-06

Recruiting

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

NCT06227910Crohn's Disease

DrugsVedolizumab·Upadacitinib

Takeda

Phase 3

396

Milan, Naples, Roma, Rozzano, San Giovanni Rotondo, Torino

2025-01-02

Recruiting

Pharmacokinetics and Safety of Givinostat in DMD Patients Ages From at Least 2 Years to Less Then 6 Years Old

NCT06769633Duchenne Muscular Dystrophy

Italfarmaco

Phase 2

Milan, Roma

2025-01-02

Recruiting

Visuo-Vestibular VR-based Stimulation Effects on Balance and Gait in Stroke Survivors

NCT06780488Stroke

I.R.C.C.S. Fondazione Santa Lucia

Not applicable

Roma

2025-01-01

Recruiting

Dental Communication and Social Media: Legal and Ethical Framework

NCT07550153Professional Ethics, Health Communication, Social Media

University of Roma La Sapienza

Observational

300

Roma

2025-01-01

Recruiting

Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes

NCT07291609Chronic Coronary Syndrome, Microplastics, Nanoplastics, Coronary Artery Disease

Azienda Ospedaliera "Sant'Andrea"

Observational

120

Caserta, Forlì, Milan, Naples, Roma, Verona

2025-01-01

Not yet open

Robotic Surgery in the Treatment of Deep Endometriosis: Da Vinci Vs HUGO RAS Comparison

NCT06781398Deep Endometriosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna, Roma

2025-01

Active, closed

A Study to Compare Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB12 (Proposed Pembrolizumab Biosimilar) to Keytruda® in Non-small Cell Lung Cancer (BENITO Study)

NCT06687369Non Squamous Non Small Cell Lung Cancer

DrugsEU sourced Keytruda·US-sourced Keytruda·Pemetrexed·Cisplatin

mAbxience Research S.L.

Phase 3

726

Brescia, Cremona, Genova, Lecce, Meldola, Pavia, Roma, Siena

2024-12-30

Recruiting

LIDRISE Study: A Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops, Single Dose) in the Treatment of Acquired Blepharoptosis.

NCT06514612Acquired Blepharophimosis

Santen SAS

Phase 3

234

Ferrara, Naples, Roma

2024-12-30

Recruiting

Size Up Bicuspid With the LIra MEthod: the SUBLIME Study

NCT06657911Bicuspid Aortic Valve (BAV)

IRCCS San Raffaele

Observational

250

Brescia, Milan, Roma

2024-12-21

Active, closed

OM 85 to Prevent Respiratory Infections in Older At Risk Patients

NCT07178002Respiratory Tract Infections (RTI)

DrugBacterial Lysate

Fondazione Policlinico Universitario Campus Bio-Medico

Phase 4

360

Roma

2024-12-19

Active, closed

A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy

NCT06742190Multifocal Motor Neuropathy (MMN), MMN

DrugsEmpasiprubart·Immunoglobulin·IVIG

argenx

Phase 3

154

Florence, Genova, Gussago, Messina, Milan, Roma, Rozzano

2024-12-18

Recruiting

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

NCT06727604Graves' Disease

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

240

Bologna, Cagliari, Genova, Milan, Naples, Pisa, Roma, Siena

2024-12-17

Recruiting

Study on Disease Characteristics and Treatment in Locally Advanced or Recurrent / Metastatic Cervical Cancer in Italy

NCT06771193Cervical Cancer, Locally Advanced Cervical Cancer, Recurrent Cervical Cancer, Metastatic Cervical Cancer

MSD Italia S.r.l.

Observational

200

Bologna, Catania, Genova, Milan, Modena, Naples, Aviano, Roma

2024-12-17

Recruiting

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

NCT06747585Squamous Non-small-cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Esophageal Squamous Cell Carcinoma

Alentis Therapeutics AG

Phase 1/2

170

Milan, Ravenna, Roma, Verona

2024-12-16

Recruiting

A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

NCT06679101Multiple Myeloma, Newly Diagnosed Multiple Myeloma

DrugsBelantamab mafodotin·Daratumumab·Lenalidomide·Dexamethasone

GlaxoSmithKline

Phase 3

520

Ancona, Catania, Meldola FC, Palermo, Pavia, Pisa, Roma

2024-12-16

Recruiting

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT06667076Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 2

480

Orbassano, Padova, Ravenna, Roma, Rozzano

2024-12-16

Active, closed

Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

NCT06608927Metastatic Pancreatic Ductal Adenocarcinoma

DrugsQuemliclustat·Nab-paclitaxel·Gemcitabine

Arcus Biosciences, Inc.

Phase 3

610

Bologna, Cremona, Florence, Milan, Modena, Padova, Piacenza, Roma

2024-12-13

Active, closed

Study Evaluating AZD7798 for Treatment in Crohn's Disease Patients With an Ileostomy

NCT06681324Crohn's Disease

DrugAZD7798

AstraZeneca

Phase 2

Padova, Roma, Rozzano

2024-12-11

Recruiting

Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia

NCT06597019Familial Hypercholesterolemia - Heterozygous

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

Milan, Roma, Torino, Verona

2024-12-09

Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 11 October 2026. https://priyalifescience.com/clinical-trials-italy/city/roma

Query this register directly

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,791 studies in total at the last sync on 11 Oct 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,272 of those studies with a site in Roma.

How many clinical trials are recruiting in Roma?

717 of the 1,272 studies on this page are recruiting new participants as of the 11 Oct 2026, 03:19 UTC sync. A further 94 have not yet opened recruitment, 435 are active but closed to new participants, and 26 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Roma), 1,272 studies
Phase	Studies	Recruiting	Share
Phase 3	422	199	33.2%
Observational	305	198	24%
Phase 2	199	106	15.6%
Not applicable	191	116	15%
Phase 1/2	66	45	5.2%
Phase 2/3	42	22	3.3%
Phase 1	24	16	1.9%
Phase 4	22	14	1.7%
Early Phase 1	1	1	0.1%

Most active sponsors

Lead sponsors with the most studies (Roma)
Lead sponsor	Studies	Recruiting
Fondazione Policlinico Universitario Agostino Gemelli IRCCS	197	110
AstraZeneca	71	31
Novartis Pharmaceuticals	52	27
Janssen Research & Development, LLC	44	21
Merck Sharp & Dohme LLC	43	28
Eli Lilly and Company	25	18
GlaxoSmithKline	25	16
Bristol-Myers Squibb	24	12
Pfizer	23	11
University of Roma La Sapienza	19	10

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.