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Clinical Trials in Italy / NCT07266441
Active, not recruiting Phase 2

A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma

NCT07266441 · tracked via the Priya Life Science Italy tracker
Phase
Phase 2
Started
2026-02-08
Last updated
2026-09-25

Condition(s) studied

Multiple Myeloma

Investigational drug(s) / intervention(s)

JNJ-79635322 →

JNJ-79635322: JNJ-79635322 will be administered as an injection under the skin.

Study summary

The purpose of this study is to evaluate how well JNJ-79635322 works (efficacy) in participants with Relapsed or Refractory Multiple Myeloma (RRMM; a cancer that forms in a type of white blood cells called a plasma cell. Cancer is called relapsed if it comes back after treatment and is called 'refractory' if does not respond to treatment) who have received at least 3 prior lines of therapy.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion: * Documented diagnosis of multiple myeloma (MM) as defined by the criteria below: 1. MM diagnosis according to the international myeloma working group (IMWG) diagnostic criteria 2. Measurable disease at screening as assessed by central laboratory * Received at least 3 prior lines of antimyeloma therapy including a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and an anti-cluster of differentiation (CD) 38 monoclonal antibody (mAb) * Documented evidence of progressive disease(PD) or failure to achieve a response to the last line of therapy based on investigator's determination of response by the IMWG criteria * Have discontinued concurrent use of any other anticancer treatment (including nonpalliative radiotherapy) or investigational agent * Have an eastern cooperative oncology group (ECOG) performance status (PS) of 0 to 2 at screening and immediately before the start of study treatment administration Exclusion: * Suspected or known allergies, hypersensitivity, or intolerance to excipients of JNJ-79635322 * Had major surgery within 2 weeks before first dose or has planned major surgery during study treatment phase * Known active or prior central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of MM * Participant has leptomeningeal disease * Participant has a prior or concurrent second malignancy the natural history or treatment of which could likely interfere with any study endpoints of safety or the efficacy of the study treatment

Primary outcome measure(s)

Trial sites (71)

FacilityCityRegionStatus
O Neal Comprehensive Cancer Center at UAB Birmingham Alabama
Banner MD Anderson Cancer Center Gilbert Arizona
City of Hope Duarte California
City of Hope Orange County Lennar Foundation Cancer Center Irvine California
Cancer and Blood Specialty Clinic Los Alamitos California
University of California San Francisco San Francisco California
Rocky Mountain Cancer Centers Aurora Colorado
Colorado Blood Cancer Institute Denver Colorado
Cancer Specialists of North Florida Jacksonville Florida
Emory University Atlanta Georgia
Northside Hospital Cancer Institute Atlanta Georgia
Cancer Care Specialists of Central Illinois O'Fallon Illinois
University of Iowa Iowa City Iowa
Mission Cancer Blood Waukee Iowa
Massachusetts General Hospital Boston Massachusetts
Rutgers Cancer Institute New Brunswick New Jersey
Memorial Sloan Kettering Cancer Center New York New York
Levine Cancer Institute Charlotte North Carolina
Cleveland Clinic Foundtation Cleveland Ohio
Oncology Associates of Oregon PC Willamette Valley Cancer Institute Eugene Oregon
University of Pennsylvania Philadelphia Pennsylvania
SCRI Oncology Partners Nashville Tennessee
Tennessee Oncology, PLLC Nashville Tennessee
Texas Oncology Austin Texas
MD Anderson Cancer Center Houston Texas
Oncology Consultants Texas Houston Texas
Texas Oncology - Northeast Tyler Texas
Virginia Cancer Specialists Fairfax Virginia
Virginia Oncology Associates Norfolk Virginia
NorthWest Medical Specialties, PLLC Tacoma Washington
Peking Union Medical College Hospital Beijing China
Beijing Chaoyang Hospital Chaoyang District China
Sun Yat Sen University Cancer Center Guangzhou China
Shanghai Fourth People s Hospital Shanghai China
Ha'Emek Medical Center Afula Israel
Samson Assuta Ashdod University Hospital Ashdod Israel
Hillel Yaffe Medical Center Hadera Israel
Hadassah Medical Center Jerusalem Israel
Rabin Medical Center Petah Tikva Israel
Tel Aviv Sourasky Medical Center Tel Aviv Israel

+ 31 more sites — see the full list on the official registry below.

More Janssen Research & Development, LLC trials in Italy

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07266441 on ClinicalTrials.gov ↗ ← All trials in Italy