Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas

Condition(s) studied

Study summary

Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes.

For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.

Eligibility

Primary outcome measure(s)

• Recurrence rate — 5 years
  The recurrence rate is defined as the proportion of patients who develop disease recurrence confirmed by imaging or histopathologic evaluation after FSS.
• Disease free survival — 5 years
  Disease-free survival is defined as the time from surgery until the first documented recurrence.
• Overall survival — 5 years
  Overall survival is measured as the time from surgery to death from any cause,

Trial sites (1)

More Fondazione Policlinico Universitario Agostino Gemelli IRCCS trials in Italy