Cardiovascular Health in Adult Patients With Cancer Exposed to Cardiotoxic Therapies

Condition(s) studied

Investigational drug(s) / intervention(s)

ECHOCARDIOGRAPHY: A complete echocardiographic exam will be performed during each cardio-oncologic evaluation.

ELECTROCARDIOGRAPHY (ECG): An ECG tracing will be obtained during each cardio-oncologic evaluation.

LABORATORY TESTS: The cardiac biomarkers high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) will be dosed according to the current recommendations of Cardio-Oncology Guidelines.

Study summary

The goal of this observational study is to evaluate the cardiovascular health and prognosis of adult patients with cancer, treated with cardiotoxic therapies.

The main purposes of the study are the following:

* Identify the demographic factors related to the onset of cardiotoxicity produced by anticancer drugs.
* Identify any subgroups more likely to develop distant major adverse cardiovascular events (MACE).
* Evaluate the usefulness of clinical, biohumoral and echocardiographic parameters for early diagnosis of cardiotoxicity.

Participants will be monitored during the anticancer treatment via clinical, laboratory and instrumental evaluation according to the recommendation of the current guidelines on Cardio-Oncology (European Society of Cardiology, 2022). Initial follow-up will be 2 years.

Eligibility

Primary outcome measure(s)

• Incidence of cardiotoxicity — 24 months
  Incidence of cancer therapy-related cardiovascular toxicity according to the definitions of the European Society of Cardiology Cardio-Oncology Guidelines, published in 2022.
• Identification of major cardiovascular adverse events (MACE) — 24 months
  Identification of cardiovascular death, non-cardiovascular death and hospitalization for cardiac causes (congestive heart failure, major arrhythmias) both during the antineoplastic treatments and in the long-survivors population.

Trial sites (1)

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