Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy

Condition(s) studied

Investigational drug(s) / intervention(s)

Observation: Observation of intraoperative and postoperative outcomes

Study summary

This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.

Aspirin is commonly used to prevent heart attacks and strokes, but it can also increase the risk of bleeding. Doctors often face a tough decision: should patients stop taking aspirin before surgery to reduce bleeding risk, or continue it to prevent blood clots?

To help answer this question, researchers will observe 100 patients, some who take aspirin regularly and some who don't, at hospitals in the U.S., Russia, and Italy. They will not change any treatments but will collect information about bleeding during surgery, blood test results, and CT scans after surgery.

The goal is to better understand the risks of continuing aspirin and to help doctors make safer decisions for future patients.

Eligibility

Primary outcome measure(s)

• Postoperative Hemorrhage Rate — 48 hours postoperatively
  The incidence of postoperative hemorrhage detected on CT scans within 48 hours after surgery.
• Intraoperative Blood Loss — From start to end of surgery
  Measured by the change in hemoglobin and hematocrit levels from preoperative baseline to immediate postoperative period.

Trial sites (3)

More Mayo Clinic trials in Italy

Other trials for the same condition