Clinical trial register · Italy

Clinical Trials in Modena, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6778 matching records held by the registry are in this view. Synced 08 Oct 2026, 03:19 UTC

6778

Studies in scope

all four open statuses

4069

Recruiting now

open to new participants

1018

Lead sponsors

across recruiting studies

Top sites

Milan 2843 Bologna 1305 Roma 1274 Naples 984 Rome 967

Trials with a site in Modena

Status

Study

Lead sponsor

Phase

Enrol

Sites in Italy

Start

Not yet open

AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR OBESITY AND CARDIOVASCULAR DISEASE PRIMARY PREVENTION IN YOUTH

NCT07505459Obesity (Disorder)

Aikaterini Karaivazoglou

Not applicable

840

Modena

2027-09-01

Not yet open

AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH

NCT07472894Anxiety Depression

University of Patras

Not applicable

1,680

Modena

2027-09-01

Not yet open

Quantification of Inspiratory Effort Through Nasal Pressure in Patients Undergoing Weaning From Invasive Mechanical Ventilation and Correlation With Clinical Outcomes

NCT05282238Respiratory Failure

University of Modena and Reggio Emilia

Observational

175

Modena

2027-05-01

Not yet open

COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"

NCT07281027New Onset Refractory Status Epilepticus, New-Onset Refractory Status Epilepticus, Febrile Infection-Related Epilepsy Syndrome (FIRES)

DrugsAnakinra·Tocilizumab

Yale University

Phase 3

438

Modena

2026-12-01

Not yet open

IntraOperative UltraSound Guided vs Wire Guided vs Magnetic Seed Guided Breast-Conserving Surgery for Non-palpable Tumors

NCT07185568Breast Cancer, Breast-Conserving Surgery

Istituto Oncologico Veneto IRCCS

Not applicable

1,302

Roma, Modena, Ortona, Padova

2026-11-04

Not yet open

Colchicine Effect on Amyotrophic Lateral Sclerosis Patients

NCT07813858Amyotrophic Lateral Sclerosis

DrugColchicine

Azienda Ospedaliero-Universitaria di Modena

Phase 2

Milan, Modena, Naples, Novara, Pavia

2026-10

Recruiting

A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)

NCT07624305Renal Insufficiency, Chronic

DrugsBalcinrenone/dapagliflozin·Dapagliflozin

AstraZeneca

Phase 3

2,800

Bari, Bologna, Cosenza, Cremona, Genoa, Milan, Modena, Naples

2026-09-01

Not yet open

Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)

NCT07817875Obesity

DrugTirzepatide

Eli Lilly and Company

Phase 3

150

Florence, Modena, Novara, Parma, Roma

2026-09

Not yet open

KV-PREDICT Diagnostic Device in Patients With Heart Failure

NCT07805213Heart Failure

KardioVis S.r.l.

Not applicable

120

Modena

2026-09

Not yet open

Italian Multicenter Experience With Radioreceptor-assisted Therapy (PRRT)

NCT07538791Pheochromocytomas, Paragangliomas

Azienda USL Reggio Emilia - IRCCS

Observational

210

Bari, Bologna, Ferrara, Meldola, Milan, Modena, Naples, Reggio Emilia

2026-08-30

Recruiting

A Prospective Observational Study on of Early-Onset Gastrointestinal Cancer: From Tumor Features to Patient Lifestyle Habits

NCT07479472Early-onset Gastrointestinal Cancer

Gruppo Oncologico Italiano di Ricerca Clinica

Observational

150

Bologna, Meldola, Mantua, Carpi, Modena, Sassuolo, Piacenza, Parma

2026-07-30

Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

NCT07497087Systemic Sclerosis

Boehringer Ingelheim

Phase 3

448

Ancona, Bari, Florence, Milan, Modena, Naples, Roma

2026-07-27

Recruiting

Avoiding Recooling After Normothermic Machine Perfusion in Liver Transplantation

NCT07692490Liver Transplantation (LT), Ischemia-Reperfusion Injury, Early Allograft Dysfunction

The Mediterranean Institute for Transplantation and Advanced Specialized Therapies

Not applicable

170

Ancona, Bari, Bergamo, Bologna, Genova, Modena, Padova, Palermo

2026-07-07

Recruiting

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

NCT07662213Type 2 Diabetes Mellitus

DrugsElecoglipron·Semaglutide

AstraZeneca

Phase 3

1,200

Bari, Bologna, Chieti, Milan, Modena, Naples, Roma

2026-07-06

Not yet open

Pilot Study to Evaluate Efficacy and Safety of Switching to BIC/FTC/TAF in PWH With a Previous Virological Failure Under CAB/RPV LAI

NCT07620652HIV Infection

Cristina Mussini

Observational

Modena

2026-07

Recruiting

A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.

NCT07652658Idiopathic Pulmonary Fibrosis (IPF)

AstraZeneca

Phase 2

359

Foggia, Forlì, Modena, Monza, Pavia, Rozzano, Siena, Torino

2026-06-11

Not yet open

Safety of Bronchoscopy in Patients With Interstitial Lung Disease

NCT07627594Interstitial Lung Disease (ILD), Bronchoscopy, Bronchoalveolar Lavage (BAL), Acute Exacerbation

University of Milan

Observational

427

Milan, Bologna, Genova, Legnano, Modena, Monza, Naples, Siena

2026-06-01

Recruiting

A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis

NCT07387549Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 3

350

Genova, Milan, Modena, Monza, Novara, Padova, Roma, Rozzano

2026-05-14

Recruiting

Observational Study of Adults and Adolescents With Erythropoietic Protoporphyria (EPP) and X-linked Porphyria (XLP)

NCT07567131Erythropoietic Protoporphyria (EPP), X-Linked Porphyria (XLP)

Portal Therapeutics, Inc.

Observational

Milan, Modena

2026-04-30

Recruiting

Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel)

NCT07404410Apathy, Apathy in Dementia

Giovanna Zamboni

Not applicable

Milan, Modena

2026-04-28

Recruiting

EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)

NCT07287670Diffuse Cutaneous Systemic Sclerosis

Mediar Therapeutics

Phase 2

Ancona, Catania, Genoa, Milan, Modena, Roma

2026-04-16

Recruiting

MONTEROSA - Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab in Patients With Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment.

NCT07607769Hepatocellular Carcinoma

AstraZeneca

Observational

200

Ancona, Bergamo, Foggia, Meldola, Milan, Modena, Naples, Padova

2026-04-16

Recruiting

Investigation of REcurrence Mechanisms to Adjuvant osimertINib in Radically Resected EGFR-mutated NSCLC Patients

NCT07363252EGFR-mutated NSCLC

DrugOsimertinib

Gruppo Oncologico Italiano di Ricerca Clinica

Observational

100

Bari, Bergamo, Bologna, Misterbianco, Monza, Milan, Modena, Padova

2026-04-14

Recruiting

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

NCT07481630Obesity, Knee Osteoarthritis (OA)

DrugNNC0487-0111

Novo Nordisk A/S

Phase 3

400

Naples, Modena, Udine, Rome, Milan, San Donato Milanese, Verona

2026-04-13

Recruiting

Bilateral Versus Unilateral Lymph Node Dissection in High-Risk Prostate Cancer (BALANCE)

NCT07580196Prostate Cancer

University of Turin, Italy

Not applicable

820

Rozzano, Bologna, Florence, Foggia, Genova, Milan, Modena, Naples

2026-03-30

Recruiting

Outcomes in ARMs: Comparison Between Surgical Techniques in Patients With Perineal or Vestibular Fistula - a Multicenter Italian Study

NCT07438691Anorectal Malformations

Meyer Children's Hospital IRCCS

Observational

500

Florence, Bergamo, Brescia, Catania, Lecce, Modena, Novara, Padova

2026-02-05

Recruiting

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

NCT07322003Amyotrophic Lateral Sclerosis

DrugPridopidine

Prilenia

Phase 3

500

Caserta, Milan, Modena, Padova, Torino

2026-02-01

Recruiting

Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis

NCT07332091Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

CSL Behring

Phase 2

Brindisi, Milan, Modena, Monza, Naples, Verona

2026-01-22

Recruiting

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

NCT07179380Pulmonary Hypertension, Interstitial Lung Disease

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 3

344

Bologna, Catania, Milan, Modena, Monza, Naples, Pavia, Roma

2026-01-07

Recruiting

A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia

NCT07144163Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 3

150

Genova, Milan, Rozzano, Modena, Padova, Palermo, Naples, Roma

2025-12-11

Recruiting

Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody

NCT07285213Clostridioides Difficile Infection

AstraZeneca

Phase 2

230

Modena, Naples, Palermo, Pisa, Roma, Varese

2025-12-10

Recruiting

A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

NCT07169851Nausea, Vomiting, Drug-Related Side Effects and Adverse Reactions, Neoplasms

Eli Lilly and Company

Phase 2

204

Ancona, Modena, Pisa, Vicenza

2025-11-28

Recruiting

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

NCT07213674Metastatic Castration-resistant Prostate Cancer

DrugsXaluritamig·Cabazitaxel·Abiraterone acetate·Docetaxel

Amgen

Phase 3

750

Foggia, Milan, Modena, Orbassano, Peschiera del Garda, Rozzano, Trento

2025-11-28

Recruiting

Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment

NCT07286448Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)

Giovanna Zamboni

Not applicable

100

Modena, Milan

2025-11-28

Active, closed

A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

NCT07170150Alzheimers Disease

DrugTrontinemab

Hoffmann-La Roche

Phase 3

1,060

Naples, Modena, Rome, Perugia

2025-11-12

Recruiting

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

NCT06793215Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer

DrugsDivarasib·Pemetrexed·Cisplatin·Carboplatin

Hoffmann-La Roche

Phase 3

600

Statte, Naples, Modena, Pesaro, Aviano, Rome, Milan, Monza MI

2025-10-24

Recruiting

Clinical Phase 2 Trial of AP31969 Versus Placebo for Rhythm Control of Atrial Fibrillation

NCT07267949Atrial Fibrillation (AF)

Acesion Pharma

Phase 2

200

Bologna, Cona, Mestre, Milan, Modena

2025-10-22

Recruiting

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

NCT07213804Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis

DrugsSofe-M·MIRV·Pegylated liposomal doxorubicin·Topotecan

Eli Lilly and Company

Phase 3

1,630

Bologna, Catania, Lecce, Lucca, Milan, Modena, Naples, Prato

2025-10-22

Recruiting

Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.

NCT07407465Colorectal Cancer, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Rectal Cancer, Adenocarcinoma

DrugsTrastuzumab deruxtecan·Capecitabine·Bevacizumab

Gruppo Oncologico del Nord-Ovest

Phase 2

Bari, Florence, Milan, Ravenna, Rozzano, Tricase, Modena, Roma

2025-10-20

Recruiting

Reference Intervals With Indirect Methods in Italy

NCT07433777Reference Intervals

Centro di Riferimento Oncologico - Aviano

Observational

1,000,000

Altamura, Ancona, Arezzo, Belluno, Florence, Milan, Modena, Monza

2025-10-08

Recruiting

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

NCT07190248Non-small Cell Lung Cancer

Drugs) Berahyaluronidase alfa·Calderasib·Paraplatin·Pemetrexed

Merck Sharp & Dohme LLC

Phase 3

675

Bolzano, Modena, Meldola, Udine, Rome, Bergamo, Rozzano, Statte

2025-10-08

Recruiting

Breast Cancer RElapsed in Patients Treated With Adjuvant CDK4/6 Inhibitors:

NCT07180693Adjuvant Therapy, CDK4/6 Inhibitor

European Institute of Oncology

Observational

750

Bergamo, Brescia, Brindisi, Crema, Lecco, Legnano, Milan, Modena

2025-09-29

Recruiting

Real-world Study to Assess Adherence to IOP Lowering Therapy in Patients With Glaucoma or Ocular Hypertension Using CONNECTDROP®

NCT07206628Adherence to Glaucoma Therapy

Laboratoires Thea

Observational

200

Bologna, Catania, Corigliano, Genova, Lecce, Lucca, Modena, Morrovalle

2025-09-19

Recruiting

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

NCT07023835Amyotrophic Lateral Sclerosis (ALS)

Zydus Therapeutics Inc.

Phase 2

240

Genova, Milan, Modena, Naples, Brescia

2025-09-17

Recruiting

Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study

NCT06928272Long COVID

DrugsPirfenidone·Upadacitinib

Douglas D. Fraser

Phase 3

348

Roma, Modena

2025-09-10

Recruiting

Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor

NCT07124130Induced Labor

Eastern Virginia Medical School

Phase 4

158

Modena

2025-09

Recruiting

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

NCT06925321Invasive Mold Infections

DrugFosmanogepix

Basilea Pharmaceutica

Phase 3

234

Genova, Milan, Modena, Pavia, Pisa, Trieste

2025-08-26

Recruiting

MELAFERT: Impact of Adjuvant Therapy on FERTility in Patients With Resected MELAnoma at High Risk of Relapse.

NCT07092670Melanoma, Fertility

DrugsDabrafenib·Trametinib·Nivolumab·Pembrolizumab

Intergruppo Melanoma Italiano

Observational

270

Bari, Genova, Milan, Modena, Naples, Padova, Perugia, Roma

2025-08-04

Recruiting

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

NCT06757634Breast Cancer

DrugsGedatolisib·Ribociclib·Palbociclib·Letrozole

Celcuity Inc

Phase 3

1,180

Fano, Genova, Meldola, Milan, Modena, Naples, Parma, Pavia

2025-07-24

Recruiting

A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma

NCT07069712Gastroesophageal Adenocarcinoma

DrugsSonesitatug Vedotin·Calcium folinate·Rilvegostomig·Trastuzumab deruxtecan

AstraZeneca

Phase 2

100

Florence, Milan, Modena, Pisa, Rozzano, Udine, Vicenza

2025-07-17

Recruiting

A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice

NCT07284121Lung Cancer, Hepatocellular Carcinoma

DrugsTecentriq·Atezolizumab

Hoffmann-La Roche

Observational

700

Lecce, Naples, Modena, Ravenna, Rome, Genoa, Bergamo, Milan

2025-07-15

Recruiting

Melanoma of the Skin and Exposure to Solar Ultraviolet Radiation at Work in Modena Territory: a Case-control Study to Promote an Active Search and Prevention of Occupational Diseases Based on Recent INAIL Criteria

NCT07251335Skin Melanoma, Cutaneous Melanoma

University of Modena and Reggio Emilia

Observational

300

Modena

2025-07-07

Recruiting

Safety and Efficacy of T-DXd vs. CDK4/6i-based ET as First-line Therapy of HR-positive and HER2-low/Ultralow Advanced Breast Cancer Patients Classified as Non-luminal Subtype

NCT06486883Advanced Breast Cancer, Advanced Breast Carcinoma, Hormone Receptor Positive Breast Carcinoma

DrugsCDK4/6i·Trastuzumab deruxtecan

MedSIR

Phase 2

200

Ancona, Aviano, Florence, Genova, Milan, Modena, Monza, Naples

2025-06-30

Recruiting

Centralization and Oncologic Outcomes in Ovarian Cancer

NCT07075939Epithelial Ovarian Cancer, Ovarian Neoplasms, Advanced Ovarian Cancer

Azienda USL Reggio Emilia - IRCCS

Observational

200

Carpi, Mirandola, Pavullo nel Frignano, Sassuolo, Vignola, Reggio Emilia, Modena

2025-06-27

By invitation

A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Moderate to Severe Hidradenitis Suppurativa

NCT07007637Hidradenitis Suppurativa

DrugSonelokimab

MoonLake Immunotherapeutics AG

Phase 3

835

Catania, Chieti, Cona, Florence, Milan, Modena, Naples, Perugia

2025-06-27

Recruiting

Phase I/IIa Study: RR001 Administered Following Chemotherapy Cycles for Patients With Locally Advanced Pancreatic Carcinoma

NCT06861452Locally Advanced Pancreatic Adenocarcinoma

EIR Biotherapies s.r.l.

Phase 1/2

Modena

2025-06-25

Active, closed

A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis

NCT06736990Idiopathic Pulmonary Fibrosis

Calluna Pharma AS

Phase 2

150

Padova, Roma, Siena, Trieste, Modena, Naples, Rozzano

2025-06-20

Recruiting

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

NCT06943872Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsSonrotoclax·Venclexta·Obinutuzumab·Venetoclax

BeOne Medicines

Phase 3

630

Bari, Cagliari, Catania, Ferrara, Milan, Modena, Pagani

2025-06-11

Recruiting

ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

NCT06902558Autosomal Dominant Polycystic Kidney Disease

Calico Life Sciences LLC

Phase 2

240

Bari, Modena, Rome

2025-06-09

Recruiting

High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project

NCT06822231Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)

Istituti Clinici Scientifici Maugeri SpA

Not applicable

124

Bari, Genova, Milan, Modena, Montescano, Pavia, Roma, Telese Terme

2025-05-28

Recruiting

Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.

NCT06697301Advanced Melanoma

DrugsEIK1001·Keytruda·Pembrolizumab

Eikon Therapeutics

Phase 2/3

740

San Giovanni Rotondo, Alessandria, Messina, Milan, Modena, Padova, Trento, Genoa

2025-05-22

Recruiting

A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)

NCT06935357Immunoglobulin A Nephropathy (IgAN)

DrugFelzartamab

Biogen

Phase 3

454

Bari, Fontevivo, Modena, Piacenza, Trieste, Genoa, Brescia, Ranica

2025-05-08

By invitation

ESCAPE10: Epidemiology, Risk Factors, and Outcomes of Severe Community-acquired Pneumonia in Elderly Patients Acquired Pneumonia in Elderly Patients

NCT07070284Severe Community-Acquired Pneumonia (sCAP), Elderly Infection, Community-Acquired Infections, Health Care Quality, Access, and Evaluation

Joan Sabater-Riera

Observational

500

Modena, Rome, Gavardo, Palermo, Pisa

2025-05-01

Recruiting

High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project

NCT06881979Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease

Istituti Clinici Scientifici Maugeri SpA

Not applicable

Genova, Milan, Modena, Montescano, Pavia, Roma, Telese Terme

2025-04-28

Recruiting

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

NCT06790693Breast Cancer

DrugsCDK4/6i·Inavolisib·Letrozole

Hoffmann-La Roche

Phase 3

450

Tricase (LE), Caserta, Naples, Bologna, Meldola, Modena, Rome, Bergamo

2025-04-09

Recruiting

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

NCT06726148Advanced HR+/HER2- Breast Cancer, Advanced CCNE1-amplified Solid Tumors, Extensive-stage Small Cell Lung Cancer

DrugsRibociclib·Fulvestrant

Novartis Pharmaceuticals

Phase 1/2

280

Milan, Modena

2025-04-03

Recruiting

Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment

NCT06750289Eosinophilic Asthma

AstraZeneca

Phase 3

400

Bari, Bergamo, Brescia, Cagliari, Catanzaro, Genoa, Milan, Modena

2025-03-28

Recruiting

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

NCT06742723Chronic Kidney Disease and Hypertension

DrugBaxdrostat/dapagliflozin

AstraZeneca

Phase 3

5,000

Bassano del Grappa, Bologna, Desio, Foggia, Genoa, Modena, Naples, Novara

2025-03-03

Recruiting

Tensi+ European Registry

NCT07205445Overactive Bladder

Stimuli Technology

Observational

500

Avellino, Florence, Modena, Montevarchi, Roma

2025-02-27

Recruiting

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

NCT06731478Gastric Cancer, Gastroesophageal Junction Cancer

DrugsTrastuzumab deruxtecan·Trastuzumab·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

726

Catania, Florenze, Genova, Milan, Modena, Naples, Padova, Pisa

2025-02-27

Recruiting

National Multicentre Study on Lipid Profile in Noonan Syndrome and Related Disorders: Trends by Age, Gender and Genotype

NCT07464821RASopathies, Noonan Syndrome

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

200

Alessandria, Bari, Bologna, Florence, Genova, Messina, Milan, Modena

2025-02-26

Recruiting

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

NCT06612268Sickle Cell Disease

DrugEtavopivat

Novo Nordisk A/S

Phase 3

510

Orbassano, Verona, Brescia, Catania, Modena, Monza, Naples, Padova

2025-02-17

Recruiting

A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

NCT06858579Chronic Inflammatory Demyelinating Polyneuropathy

DrugClaseprubart

Dianthus Therapeutics

Phase 3

256

Bergamo, Bologna, Genova, Gussago, Milan, Modena, Monza, Pavia

2025-02-10

Recruiting

LEOPARD Training and Validation Data Collection Study

NCT06675604Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma

Assistance Publique - Hôpitaux de Paris

Observational

4,500

Ancona, Bari, Bologna, Genova, Milan, Modena, Naples, Padova

2025-02-04

Active, closed

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)

NCT06799000Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

588

Ancona, Brescia, Catania, Cona, Florence, Rozzano, Modena, Pisa

2025-01-31

Recruiting

Radiologic Features of Rheumatoid Arthritis Interstitial Lung Disease at Chest High Resolution Computed Tomography

NCT07174102Reumatoid Arthritis, Interstitial Lung Disease Due to Systemic Disease (Disorder), Idiopathic Pulmonary Fibrosis (IPF), Connective Tissue Disease (CTD)

Azienda Unita Sanitaria Locale di Piacenza

Observational

500

Ferrara, Modena, Piacenza, Reggio Emilia

2025-01-08

Recruiting

Study on Disease Characteristics and Treatment in Locally Advanced or Recurrent / Metastatic Cervical Cancer in Italy

NCT06771193Cervical Cancer, Locally Advanced Cervical Cancer, Recurrent Cervical Cancer, Metastatic Cervical Cancer

MSD Italia S.r.l.

Observational

200

Bologna, Catania, Genova, Milan, Modena, Naples, Aviano, Roma

2024-12-17

Active, closed

Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

NCT06608927Metastatic Pancreatic Ductal Adenocarcinoma

DrugsQuemliclustat·Nab-paclitaxel·Gemcitabine

Arcus Biosciences, Inc.

Phase 3

610

Bologna, Cremona, Florence, Milan, Modena, Padova, Piacenza, Roma

2024-12-13

Recruiting

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

NCT05421858Candidemia, Candidiasis, Invasive

DrugsCaspofungin·Fosmanogepix·Fluconazole

Basilea Pharmaceutica

Phase 3

450

Cuneo, Genoa, Milan, Modena, Pavia, Pisa, Siena, Trieste

2024-12-11

Recruiting

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.

NCT06382948Advanced Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, ESR1 Gene Mutation

DrugsElacestrant·Everolimus

MedSIR

Phase 3

300

Bergamo, Cagliari, Florence, Genova, Livorno, Milan, Modena, Monza

2024-12-05

Recruiting

Genetic Newborn Screening for Rare Diseases Within the Screen4Care Project

NCT06549218Newborn Screening

University Hospital Freiburg

Not applicable

20,000

Rome, Ferrara, Modena, Roma

2024-12-03

Recruiting

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

NCT06672549Obesity, Overweight

DrugOrforglipron

Eli Lilly and Company

Phase 3

125

Florence, Modena, Novara, Parma, Roma, Verona

2024-11-18

Active, closed

A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia

NCT06637501Chronic Lymphocytic Leukemia

DrugsSonrotoclax·Zanubrutinib

BeOne Medicines

Phase 2

Brescia, Florence, Modena, Palermo

2024-11-14

Recruiting

LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis

NCT06632457Metabolic Dysfunction Associated Steatohepatitis

Boehringer Ingelheim

Phase 3

1,590

Bologna, Foggia, Milan, Modena, Palermo, Rome, Rozzano, Torino

2024-11-12

Recruiting

A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis

NCT06655155Systemic Sclerosis (SSc)

argenx

Phase 2

Florence, Milan, Modena, Naples, Roma, Rozzano

2024-11-11

Recruiting

Lung Ultrasound Score for Early Prediction of Bronchopulmonary Dysplasia in Preterm Newborns

NCT07633184Bronchopulmonary Dysplasia

Azienda USL Reggio Emilia - IRCCS

Observational

Modena, Padova, Reggio Emilia, Roma

2024-11-02

Recruiting

CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure

NCT06989385Acute Respiratory Failure

University of Modena and Reggio Emilia

Observational

325

Modena

2024-11-01

Recruiting

TeleNEURO-Rehabilitation Systems for Neurodegenerative Conditions: the FIT4TeleNEURO Pragmatic Trial

NCT06685744Parkinson Disease, Multiple Sclerosis, Neurologic Diseases, General

Fondazione Don Carlo Gnocchi ETS

Not applicable

300

Bari, Genova, Lecco, Milan, Modena, Pavia

2024-10-23

Active, closed

A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)

NCT06643481Amyotrophic Lateral Sclerosis (ALS)

DrugVHB937

Novartis Pharmaceuticals

Phase 2

251

Milan, Modena, Pisa, Torino

2024-10-17

Recruiting

LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

NCT06632444Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis

Boehringer Ingelheim

Phase 3

1,800

Bologna, Foggia, Milan, Modena, Novara, Palermo, Rome, Rozzano

2024-10-14

Active, closed

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

NCT06598943Ulcerative Colitis, Ulcerative Colitis Chronic

DrugMirikizumab

Eli Lilly and Company

Phase 2

143

Bologna, Brescia, Fano, Florence, Gazzi - Messina, Milan, Modena, Monserrato

2024-10-10

Recruiting

A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis

NCT06470048Diffuse Cutaneous Systemic Sclerosis

DrugIanalumab

Novartis Pharmaceuticals

Phase 2

200

Ancona, Milan, Rozzano, Modena, Palermo, Pavia, Roma, Verona

2024-10-09

Recruiting

A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease

NCT06572384Lung Diseases, Interstitial

DrugBelimumab

GlaxoSmithKline

Phase 3

440

Ancona, Milan, Modena, Naples, Padova, Palermo, Pavia, Pisa

2024-09-11

Active, closed

Evaluation of the Effect of Lomitapide Treatment on Major Adverse Cardiovascular Events (MACE) in Patients With Homozygous Familial Hypercholesterolemia

NCT06832371Homozygous Familial Hypercholesterolemia (HoFH), Major Adverse Cardiovascular Events (MACE), Dyslipidemia

Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)

Observational

Catanzaro, Caserta, Naples, Bologna, Ferrara, Modena, Genova, Catania

2024-09-09

Recruiting

Prognostic and Predictive Role of Intrinsic Molecular Subtypes in BRCA-associated Breast Cancer

NCT07617025Breast Cancer

Angela Toss

Observational

100

Genova, Milan, Modena, Padova, Roma

2024-09-05

Active, closed

Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)

NCT06564142Immunoglobulin A Nephropathy

DrugPovetacicept

Alpine Immune Sciences Inc, A Subsidiary of Vertex

Phase 3

605

Bari, Genova, Modena, Pavia, Rome

2024-08-30

Recruiting

Real wOrld studY in the Adjuvant Setting for High Risk earLy Breast Cancer Patients

NCT07151911Breast Cancer

Azienda Ospedaliero-Universitaria di Modena

Observational

100

Modena

2024-08-26

Recruiting

A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

NCT06435429Metastatic HER2-positive Breast Cancer

DrugsZanidatamab·Eribulin·Vinorelbine·Trastuzumab

Jazz Pharmaceuticals

Phase 3

550

Aviano, Bergamo, Bologna, Milan, Modena, Monza, Padova, Pavia

2024-08-13

Recruiting

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

NCT06380751Advanced Breast Cancer

DrugsSaruparib·Camizestrant·Exemestane·Anastrozole

AstraZeneca

Phase 3

788

Bergamo, Bologna, Milan, Modena, Naples, Padova, Reggio Emilia, Rome

2024-08-01

Recruiting

How Complexity and Multiple Illnesses Affect Hospitalized Patients' Health: a Multicenter Study

NCT06872632Complexity and Multiple Illnesses of Adult Hospitalized Internal Medicine Patient

Società Italiana di Medicina Interna

Observational

2,326

Bari, Bologna, Brescia, Ferrara, Florence, Messina, Milan, Modena

2024-06-24

Recruiting

Clinical Management and Outcomes of Primary Ovarian Leiomyosarcoma

NCT06749600Primary Ovarian Leiomyosarcoma

Azienda USL Reggio Emilia - IRCCS

Observational

Modena, Parma, Reggio Emilia, Avellino, Catania, Milan, Monza, Naples

2024-06-14

Recruiting

IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

NCT06112314Advanced Melanoma

DrugsBrenetafusp·Relatlimab·Opdivo·Nivolumab

Immunocore Ltd

Phase 3

680

Bari, Bergamo, Meldola, Milan, Modena, Naples, Padova, Perugia

2024-06-05

Recruiting

Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in NICU.

NCT05993442Infection, Bacterial, Infection Prevention

PENTA Foundation

Not applicable

3,080

Ferrara, Modena, Palermo, Vicenza

2024-05-28

Recruiting

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

NCT06237452Clostridium Difficile, Clostridium Difficile Infections, Clostridium Difficile Infection Recurrence, Clostridioides Difficile Infection

Vedanta Biosciences, Inc.

Phase 3

852

Alessandria, Lecco, Milan, Monza, Naples, Pavia, Modena, Roma

2024-05-20

Active, closed

A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

NCT06238622Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis

DrugNerandomilast

Boehringer Ingelheim

Phase 3

1,666

Brescia, Catania, Florence, Foggia, Forlì, Milan, Modena, Monza

2024-05-06

By invitation

CoMPaSS-NMD - Computational Models for New Patients Stratification Strategies of HNMD

NCT06734949Neuromuscular; Disorder, Hereditary

University of Modena and Reggio Emilia

Observational

500

San Miniato, Modena

2024-05-01

Active, closed

An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)

NCT06073132Generalized Epidermolysis Bullosa Simplex

TWi Biotechnology, Inc.

Phase 2/3

Milan, Modena, Rome

2024-04-04

Active, closed

HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array

NCT05952648HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

126

Bologna, Florence, Modena, Roma

2024-04-03

Recruiting

A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies

NCT06274515Breast Cancer

Hoffmann-La Roche

Phase 4

320

Meldola, Modena, Aviano (PN), Rome, Milan

2024-04-02

Recruiting

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

NCT06318169Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis

DrugPegozafermin

89bio, Inc.

Phase 3

1,350

Bergamo, Foggia, Milan, Modena, Naples, Novara, Palermo, Roma

2024-03-13

Active, closed

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor

NCT06241118Dermatitis Atopic

DrugsPimecrolimus·Amlitelimab·Tacrolimus

Sanofi

Phase 3

464

Turin, Chieti, Modena, Naples, Perugia

2024-02-29

Recruiting

Influence of Frailty on Cardiovascular Events and Mortality in Patients With COPD.

NCT05922202Role of Frailty in COPD

Azienda Ospedaliero-Universitaria di Modena

Observational

300

Modena

2024-02-23

Recruiting

The Effect of the Association EGCG, Folic Acid and Vitamin B12 in Preventing the Persistence of HPV Infection.

NCT06285357HPV Infection

Lo.Li.Pharma s.r.l

Not applicable

100

Modena

2024-02-19

Recruiting

Impact of Graft Reconditioning With Hypothermic Machine Perfusion on HCC Recurrence After Liver Transplantation

NCT06236568Hepatocellular Carcinoma, Liver Transplant; Complications

Azienda Ospedaliero-Universitaria di Modena

Not applicable

Modena

2024-02-06

Recruiting

Treatment and Outcome of Patients With Mild Head Injury

NCT07339319Head Injury Trauma

Azienda USL Reggio Emilia - IRCCS

Observational

4,500

Bologna, Modena, Reggio Emilia

2024-02-01

Recruiting

The PRO-FUTURE Project

NCT06382233Ureteropelvic Junction Obstruction, Chronic Kidney Diseases

University of Campania Luigi Vanvitelli

Observational

Naples, Milan, Modena

2024-01-30

Recruiting

First-in-human Study to Examine Safety of a New Peritoneal Dialysis Device (WEAKID) in End-stage Kidney Disease Patients

NCT06314503Renal Insufficiency, Chronic, Kidney Failure, Chronic, Chronic Kidney Diseases

UMC Utrecht

Not applicable

Modena

2024-01-22

Recruiting

"Fetal gRowth AbnorMality dEtection Trial"

NCT05043753Small for Gestational Age Infant, Large for Gestational Age Infant, Oligohydramnios, Polyhydramnios

University of Modena and Reggio Emilia

Not applicable

1,566

Modena, Cesena, Monza

2024-01-20

Recruiting

Home Ultra-long Term EEG Monitoring for Rare Epilepsies and Developmental and Epileptic Encephalopathies

NCT06855901Epilepsies, Epilepsies, Focal, Epileptic Encephalopathy

Azienda Ospedaliero-Universitaria di Modena

Not applicable

Roma, Trieste, Modena, Naples

2024-01-17

Recruiting

Genotype-phenotype Relationship Between Cryptogenic Cholestasis and Familial Intrahepatic Cholestasis

NCT06781242Cholestatic Liver Disease, Intrahepatic Cholestasis, Progressive Familial Intrahepatic Cholestasis, Hepatobiliary Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

300

Bologna, Modena

2024-01-16

Recruiting

Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine

NCT07159750Migraine, Episodic Migraine, Chronic Migraine, Headache

Hospital Universitari Vall d'Hebron Research Institute

Observational

700

L’Aquila, Modena, Pavia, Roma

2024-01-02

Recruiting

Safety and Efficacy of MSC-EVs in the Prevention of BPD in Extremely Preterm Infants

NCT06279741Bronchopulmonary Dysplasia

EXO Biologics S.A.

Phase 1/2

265

Florence, Genova, Milan, Modena, Padua

2023-12-28

Active, closed

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)

NCT05973773Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation

DrugZipalertinib

Taiho Oncology, Inc.

Phase 3

285

Meldola, Genova, Milan, Modena, Pavia, Ravenna, Roma, Verona

2023-12-18

Recruiting

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

NCT06129864Locally Advanced Head and Neck Squamous Cell Carcinoma

DrugVolrustomig

AstraZeneca

Phase 3

1,145

Aviano, Florence, Milan, Modena, Naples, Padova, Pavia, Rozzano

2023-12-14

Recruiting

A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

NCT06091865Diffuse Large B-cell Lymphoma (DLBCL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

904

Meldola, Monza, Turin, Milan, Modena, Naples, Novara, Pavia

2023-12-13

Active, closed

A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)

NCT05993234HER2-positive Advanced Gastric Cancer, HER2-positive Gastroesophageal Junction Adenocarcinoma

DrugTrastuzumab deruxtecan

Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Observational

257

Castellana Grotte, Catania, Florence, Genova, Milan, Modena, Naples, Pisa

2023-12-05

Recruiting

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NCT06215716NASH With Fibrosis, MASH With Fibrosis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

1,650

San Giovanni Rotondo, Rozzano, Torino, Bologna, Foggia, Messina, Milan, Modena

2023-12-01

Recruiting

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

NCT06103864Breast Cancer

DrugsDato-DXd·Durvalumab·Nab-paclitaxel·Gemcitabine

AstraZeneca

Phase 3

625

Bergamo, Empoli, Milan, Modena, Naples, Padova, Reggio Emilia, Roma

2023-11-23

Active, closed

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

NCT06016738Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Exemestane·Anastrozole·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

510

Avellino, Bologna, Meldola, Modena, Reggio Emilia, Udine, Rome, Milan

2023-11-16

Active, closed

Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.

NCT06042478Chronic Spontaneous Urticaria

DrugsOmalizumab·Remibrutinib

Novartis Pharmaceuticals

Phase 3

470

Milan, Rozzano, Modena, Roma, Siena

2023-11-15

Active, closed

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

NCT06112379Breast Cancer

DrugsDato-DXd·Epirubicin·Xeloda·Olaparib

AstraZeneca

Phase 3

1,902

Empoli, Lucca, Milan, Modena, Naples, Padova, Province of Macerata, Roma

2023-11-14

Active, closed

A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma

NCT06097364Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

733

Meldola, Turin, Palermo, Milan, Modena, Naples, Perugia, Pisa

2023-11-14

Recruiting

CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative Chemotherapy Versus Immediate Resection in patIents With resecTable BiliarY Tract Cancers (BTC) at High Risk for Recurrence

NCT06037980Biliary Tract Cancer, Cholangiocarcinoma

DrugsAbraxane·Nab-paclitaxel·Capecitabine·Gemcitabine

Gruppo Oncologico del Nord-Ovest

Phase 2/3

300

Ancona, Bergamo, Bologna, Brescia, Cuneo, Meldola, Milan, Modena

2023-11-07

Recruiting

Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions

NCT07277920Melanocytic Nevi, Melanoma (Skin Cancer), Next Generation Sequencing (NGS)

University of Modena and Reggio Emilia

Observational

200

Modena

2023-11-01

Recruiting

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

NCT05696626Metastatic Breast Cancer

DrugsAbemaciclib·Fulvestrant

LeonaBio

Phase 3

600

Ancona, Aviano, Candiolo, Meldola, Milan, Misterbianco, Modena, Naples

2023-10-31

Recruiting

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

NCT05943535Progressive Pulmonary Fibrosis, Interstitial Lung Disease

DrugTreprostinil

United Therapeutics

Phase 3

698

Catania, Forlì, Modena, Monza, Roma, Siena, Verona

2023-10-30

Active, closed

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

NCT06025578Progressive Pulmonary Fibrosis

DrugAdmilparant

Bristol-Myers Squibb

Phase 3

1,057

Ancona, Modena, Florence, Milan, Pisa, Roma, Trieste, Bergamo

2023-10-25

Active, closed

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

NCT06047080Large B-Cell Lymphoma

DrugsPolatuzumab Vedotin·Glofitamab·Doxorubicin·Prednisone

Hoffmann-La Roche

Phase 3

1,130

Naples, Bologna, Modena, Genoa, Bergamo, Milan, Rozzano, Catania

2023-09-18

Active, closed

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis

NCT06003426Idiopathic Pulmonary Fibrosis

DrugAdmilparant

Bristol-Myers Squibb

Phase 3

1,255

Bologna, Modena, Florence, Milan, Pisa, Roma, Ancona, Bergamo

2023-09-14

Recruiting

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

NCT06051617Primary Biliary Cholangitis

DrugSeladelpar

Gilead Sciences

Phase 3

402

Ancona, Castellana Grotte, Milan, Modena, Monza, Padova, Palermo, Pisa

2023-09-07

Recruiting

Safety and Efficacy of Anakinra Treatment for Patients With Post Acute Covid Syndrome

NCT05926505Post-Acute COVID-19 Syndrome, Post-Acute COVID-19, Long COVID

DrugAnakinra

Hellenic Institute for the Study of Sepsis

Phase 2/3

182

Genova, Jesolo, Milan, Modena, Rome

2023-09-06

Recruiting

Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients With Relapsed or Refractory Marginal Zone Lymphoma

NCT06006117Marginal Zone Lymphoma

DrugsMosunetuzumab·Bendamustine·Lenalidomide·Rituximab

The Lymphoma Academic Research Organisation

Phase 3

260

Bologna, Castelfranco Veneto, Cuneo, Latina, Lecce, Milan, Modena, Pavia

2023-09-05

Recruiting

A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis

NCT06016842Primary Biliary Cholangitis (PBC)

DrugElafibranor

Ipsen

Phase 3

276

Modena, Monza, Naples, Padova, Palermo, Pavia, Pisa, San Giovanni Rotondo

2023-08-31

Recruiting

Diagnosis and Outcomes of Placental Accretism

NCT06833606Placenta Accreta

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna, Cesena, Forlì, Modena, Parma, Reggio Emilia, Rimini

2023-07-17

Active, closed

A Study of Zigakibart in Adults With IgA Nephropathy

NCT05852938IgA Nephropathy, Immunoglobulin A Nephropathy

DrugZigakibart

Novartis Pharmaceuticals

Phase 3

383

Bari, Foggia, Naples, Modena, Trieste, Pavia, Ranica

2023-07-06

Recruiting

Inspiratory Effort Assessed Through Nasal Pressure Measurement in Patients With Idiopathic Pulmonary Fibrosis

NCT05310669Fibrosis, Pulmonary

University of Modena and Reggio Emilia

Observational

100

Modena

2023-07-01

Recruiting

HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis

NCT07373288Fibrosis, Pulmonary

University of Modena and Reggio Emilia

Observational

Modena

2023-07-01

Active, closed

A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

NCT05889182Hidradenitis Suppurativa

DrugUpadacitinib

AbbVie

Phase 3

1,328

Cona, Florence, L’Aquila, Rome, Brescia, Milan, Modena, Pisa

2023-06-21

Recruiting

Ganciclovir Resistant/Refractory Cytomegalovirus Infection in SOT Recipients and HSCT Patients

NCT05234723Cytomegalovirus Infections

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna, Rozzano, Palermo, Genova, Milan, Modena, Naples, Padova

2023-06-19

Recruiting

Axitinib Intensification Plus Nivolumab or Nivolumab Alone After Nivolumab Plus Ipilimumab in mRCC Patients

NCT05817903Metastatic Renal Cell Carcinoma

DrugsAxitinib·Nivolumab

Consorzio Oncotech

Phase 2

118

Brescia, Candiolo, Catania, Cremona, Florence, Genova, Milan, Modena

2023-04-18

Active, closed

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

NCT05794906Biochemically Recurrent Prostate Cancer

DrugDarolutamide

Bayer

Phase 3

985

Foggia, Naples, Bologna, Modena, Reggio Emilia, Aviano, Rome, Genoa

2023-04-03

Recruiting

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

NCT05774951Breast Cancer, Early Breast Cancer

DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole

AstraZeneca

Phase 3

4,300

Bari, Catania, Catanzaro, Florence, Genova, Grosseto, Milan, Modena

2023-03-31

Active, closed

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

NCT05669755Cardiovascular Disease

DrugsCagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

7,101

Chieti, Bari, Modena, Parma, Rome, San Donato Milanese (MI), Latina, Pavia

2023-03-01

Active, closed

VIATORR Device Registry

NCT05661331Chronic Liver Disease

W.L.Gore & Associates

Observational

196

Florence, Modena

2023-02-21

Recruiting

Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies

NCT05682378Heterozygous or Homozygous Familial Hypercholesterolemia

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

195

Milan, Modena, Roma

2023-02-10

Recruiting

End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation

NCT05098717Idiopathic Pulmonary Fibrosis, Mechanical Ventilation Pressure High

University of Modena and Reggio Emilia

Observational

Modena

2023-02-08

Active, closed

Phase 2b Study of GSK4532990 in Adults With NASH

NCT05583344Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease

DrugGSK4532990

GlaxoSmithKline

Phase 2

284

Florence, Milan, Modena, Padova, Palermo, Roma, Rozzano MI, San Giovanni Rotondo FG

2023-01-02

Active, closed

A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis.

NCT05627362Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 2

Modena, Padova, Palermo, Rozzano, San Giovanni Rotondo

2022-12-29

Recruiting

Multicenter Italian Cohort Study on Tuberculosis in Pediatric Age

NCT06289660Tuberculosis Infection

Meyer Children's Hospital IRCCS

Observational

1,000

Florence, Bari, Belluno, Bologna, Genova, Milan, Modena, Naples

2022-12-22

Recruiting

Atezolizumab-bevacizumab and Other Immunotherapies: Real-life Experience for Treatment of Hepatocellular Carcinoma

NCT06806579Hepatocellular Carcinoma (HCC)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,000

Torrette, Castellana Grotte, Bologna, Catania, Foggia, Florence, Modena, Milan

2022-12-21

Recruiting

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

NCT05232916Breast Cancer

Greenwich LifeSciences, Inc.

Phase 3

2,250

Bologna, Genova, Milan, Modena, Naples, Novara, Padova, Pavia

2022-12-16

Active, closed

A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)

NCT05668988Non-small Cell Lung Cancer

DrugsSunvozertinib·Pemetrexed·Carboplatin

Dizal Pharmaceuticals

Phase 3

324

Aviano, Bologna, Catania, Florence, Grosseto, Meldola, Modena, Monza

2022-12-13

Recruiting

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

NCT05633654Triple Negative Breast Cancer

DrugsXeloda·Sacituzumab Govitecan·Keytruda·Capecitabine

Gilead Sciences

Phase 3

1,514

Bari, Bologna, Florence, Genova, Meldola, Milan, Misterbianco, Modena

2022-12-12

Active, closed

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

NCT05501886Breast Cancer

DrugsGedatolisib·Alpelisib·Palbociclib·Fulvestrant

Celcuity Inc

Phase 3

701

Milan, Modena, Monza, Parma, Prato, Rome, Udine

2022-12-08

Active, closed

Safety and Efficacy of FT14 Conditioning for Allogeneic HSCT in Acute Myeloid Leukemia

NCT07232953Acute Myeloid Leukaemia (AML), Hematopoietic Stem Cell Transplant (HSCT)

DrugsTreosulfan·Fludarabine

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Phase 2

Reggio Calabria, Naples, Modena, Udine, Brescia, Milan, Cuneo, Ancona

2022-11-10

Active, closed

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

NCT05544929Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma, Carcinoma, Renal Cell, Carcinoma, Ovarian Epithelial

DrugsKeytruda·Pembrolizumab

Novartis Pharmaceuticals

Phase 1

126

Milan, Modena

2022-10-26

Active, closed

The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study

NCT05409976Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis

W.L.Gore & Associates

Not applicable

136

Milan, Modena

2022-10-25

Recruiting

Clinics and Epidemiology of Pituitary Diseases in Modena Area Population

NCT05601141Pituitary

Azienda Ospedaliero-Universitaria di Modena

Observational

1,500

Modena

2022-10-24

Active, closed

A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp

NCT05387525Keratosis, Actinic

DrugDiclofenac Sodium

Almirall, S.A.

Phase 4

447

Arezzo, Brescia, Genova, Modena, Naples, Reggio Emilia, Roma, Rozzano

2022-10-24

Active, closed

A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer

NCT05587296Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes

Bayer

Phase 3

474

Naples, Modena, Rome, Genoa, Milan, Pavia, Turin, Florence

2022-10-14

Recruiting

Met Non Small Cell Cancer Registry (MOMENT)

NCT05376891Cancer

EMD Serono Research & Development Institute, Inc.

Observational

700

Misterbianco, Milan, Modena, Naples, Rome, Torino, Varese

2022-10-04

Active, closed

Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of RXC007 in Idiopathic Pulmonary Fibrosis

NCT05570058IPF, Fibrosis

Redx Pharma Ltd

Phase 2

Ancona, Catania, Foggia, Lecce, Milan, Modena, Roma, Verona

2022-09-08

By invitation

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

NCT04905693Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Progressive Pulmonary Fibrosis

DrugTreprostinil

United Therapeutics

Phase 3

1,850

Modena, Rome, Milan, Catania, Siena, Ancona, Forlì, Roma

2022-09-06

Recruiting

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

NCT05386108Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms

DrugsElacestrant·Abemaciclib

Stemline Therapeutics, Inc.

Phase 1/2

Ancona, Candiolo, Meldola, Messina, Milan, Modena, Monza, Naples

2022-08-31

Active, closed

Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen

NCT05502341HIV-1-infection

DrugsBictegravir·Lenacapavir

Gilead Sciences

Phase 2/3

689

Milan, Modena, Roma, Torino

2022-08-16

Active, closed

Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

NCT05261399Carcinoma, Non-Small-Cell Lung

DrugsSavolitinib·Tagrisso·Osimertinib·Pemetrexed

AstraZeneca

Phase 3

341

Avellino, Aviano, Catania, Meldola, Milan, Modena, Monserrato, Naples

2022-08-03

Active, closed

A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

NCT05306340Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Tamoxifen·Exemestane·Everolimus

Genentech, Inc.

Phase 3

373

Modena, Rome, Genoa, Milan, Torrette Di Ancona, Verona

2022-08-03

Active, closed

A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)

NCT05374512Breast Cancer

DrugsEribulin·Dato-DXd·Nab-paclitaxel·Capecitabine

AstraZeneca

Phase 3

644

Borgo San Lorenzo, Catanzaro, Genova, Livorno, Milan, Modena, Naples, Province of Macerata

2022-05-16

By invitation

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab

NCT05303532Cancer

DrugDurvalumab

AstraZeneca

Phase 3

214

Arezzo, Bari, Catania, Meldola, Milan, Modena, Padova, Pisa

2022-04-19

Active, closed

Olorofim Aspergillus Infection Study

NCT05101187Invasive Aspergillosis

DrugAmbisome

F2G Biotech GmbH

Phase 3

225

Naples, Monza, Rozzano, Genova, Milan, Modena, Perugia, Pisa

2022-03-31

Active, closed

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

NCT05064878CDKL5 Deficiency Disorder, Generalized Tonic Clonic Seizure, Epileptic Spasm, Refractory Seizures

DrugFintepla

Zogenix, Inc.

Phase 3

Florence, Genova, Modena, Roma, Verona

2022-03-08

Recruiting

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

NCT05128825High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

DrugAzenosertib

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 2

310

Naples, Modena, Aviano, Rome, Milan, Verona, Bologna

2022-02-17

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)

NCT05031780Sickle Cell Disease

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 2/3

286

Naples, Modena, Rome, Genoa, Palermo

2022-02-11

Active, closed

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

NCT05081609Advanced Solid Tumor, Locally Advanced Solid Tumor, Metastatic Solid Tumor, Platinum-resistant Ovarian Cancer

DrugsTrastuzumab emtansine·Trastuzumab·Pembrolizumab

Ascendis Pharma Oncology Division A/S

Phase 1/2

320

Cuneo, Florence, Grosseto, Lido di Camaiore, Livorno, Meldola, Milan, Modena

2022-01-11

Recruiting

LDLT in Non Resectable Colo-rectal Cancer Liver Metastasis

NCT05186116Colon Adenocarcinoma, Liver Metastasis Colon Cancer

Azienda Ospedaliero-Universitaria di Modena

Not applicable

Modena

2022-01-01

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)

NCT04770753Non-Transfusion-dependent Alpha-Thalassemia, Non-Transfusion-dependent Beta-Thalassemia

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 3

194

Brindisi, Cagliari, Ferrara, Genova, Milan, Modena, Naples, Orbassano

2021-12-20

Active, closed

Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)

NCT04954859Hepatitis B

DrugBepirovirsen

GlaxoSmithKline

Phase 2

360

Bergamo, Milan, Modena, Naples, Palermo, Pisa

2021-12-14

Active, closed

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)

NCT05156281Relapsing Multiple Sclerosis

DrugsTeriflunomide·Remibrutinib

Novartis Pharmaceuticals

Phase 3

1,007

Brindisi, Foggia, Pozzilli, Messina, Modena, Pavia, Orbassano, Naples

2021-12-13

Active, closed

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

NCT05152147Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma

DrugsZanidatamab·Herceptin·Trastuzumab·Adrucil

Jazz Pharmaceuticals

Phase 3

920

Bologna, Candiolo, Genova, Meldola, Milan, Modena, Reggio Emilia, Rome

2021-12-02

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

NCT04770779Transfusion-dependent Alpha-Thalassemia, Transfusion-dependent Beta-Thalassemia

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 3

258

Brindisi, Cagliari, Ferrara, Genova, Milan, Modena, Naples, Orbassano

2021-11-30

Recruiting

Recurrence Rate After Endoscopic Resection of , Laterally Spreading Tumor Granular Type (LST-G) of the Colon and Rectum: Endoscopic Mucosal Resection vs. Endoscopic Submucosal Dissection

NCT06815406Colorectal Cancer

Azienda USL Reggio Emilia - IRCCS

Not applicable

282

Bologna, Genova, Milan, Modena, Reggio Emilia

2021-11-18

Active, closed

A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET

NCT05050942Gastro-enteropancreatic Neuroendocrine Tumor

DrugsCAM2029·Octreotide LAR

Camurus AB

Phase 3

332

Bari, Bologna, Brescia, Florence, Genova, Meldola, Milan, Modena

2021-10-22

Recruiting

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

NCT05123482Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer, Endometrial Cancer

DrugsPalacaparib·Saruparib·Rilvegostomig

AstraZeneca

Phase 1/2

460

Milan, Modena, Roma

2021-10-18

Active, closed

Observational GORE® VIABAHN® Endoprosthesis With PROPATEN Bioactive Surface Global Registry

NCT04907240Peripheral Artery Disease, Popliteal Aneurysm, Hemodialysis Access, Visceral Artery Aneurysms

W.L.Gore & Associates

Observational

614

Ancona, Brescia, Modena, Torino, Varese

2021-10-09

Active, closed

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

NCT05050136Primary Biliary Cholangitis, PBC

DrugVolixibat

Mirum Pharmaceuticals, Inc.

Phase 2

333

Ancona, Bergamo, Milan, Modena, Monza, Padova, Palermo, Pisa

2021-09-22

Active, closed

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

NCT04965493Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsRiabni·Ruxience·Truxima·Pirtobrutinib

Loxo Oncology, Inc.

Phase 3

600

Bologna, Catanzaro, Cona, Cuneo, Florence, Meldola, Milan, Modena

2021-09-20

Active, closed

Sequential Treatment With Ponatinib and Blinatumomab vs Chemotherapy and Imatinib in Newly Diagnosed Adult Ph+ ALL

NCT04722848Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive), ALL, Adult, Philadelphia-Positive ALL

DrugsPonatinib·Imatinib·Blinatumomab

Gruppo Italiano Malattie EMatologiche dell'Adulto

Phase 3

236

Ascoli Piceno, Bari, Bergamo, Bolzano, Brescia, Mestre, Modena, Pagani

2021-09-08

Active, closed

Psychosocial Intervention for Behavioral Symptoms in Hospitalized Patients With Dementia or Delirium

NCT07778329BPSD (Behavioral and Psycological Symptoms of Dementia)

Azienda Ospedaliero-Universitaria di Modena

Not applicable

132

Modena

2021-09-01

Active, closed

Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)

NCT05005975EPP, XLP

Tanabe Pharma America, Inc.

Phase 3

286

Roma, Brescia BS, Cuneo CN, Genova GE, Milan, Modena, Trieste TS

2021-08-10

Recruiting

Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)

NCT06775457SARS CoV-2, Kawasaki Disease, Retrovirus Infection

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

120

Carpi, Bologna, Modena, Roma, Torino

2021-06-10

Active, closed

Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)

NCT04704934Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsRamucirumab·Trastuzumab deruxtecan·Paclitaxel

Daiichi Sankyo

Phase 3

490

Barone, Candiolo, Catanzaro, Milan, Modena, Naples, Padua, Pisa

2021-05-21

Active, closed

Endometrial Carcinoma: Comparison of Surgical Approaches (Laparoscopy vs Laparotomy)

NCT06790004Endometrial Carcinoma

Azienda USL Reggio Emilia - IRCCS

Observational

700

Reggio Emilia, Bologna, Ferrara, Forlì, Modena, Parma, Rimini

2021-05-10

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

NCT04873362Breast Cancer

DrugsTrastuzumab emtansine·Herceptin·Tecentriq·Trastuzumab

Hoffmann-La Roche

Phase 3

1,188

Avellino, Naples, Modena, Aviano, Rome, Brescia, Milan, Livorno

2021-05-04

Recruiting

ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)

NCT04883905Acute Hepatic Porphyria

Alnylam Pharmaceuticals

Observational

150

Milan, Modena

2021-04-26

Active, closed

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

NCT04736706Carcinoma, Renal Cell

DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda

Merck Sharp & Dohme LLC

Phase 3

1,688

Modena, Rome, Bari, Milan, Naples, Terni

2021-04-14

Recruiting

BoStOn SCientific Rhythm MAnagemenT REgiStry

NCT04823663Cardiac Disease

Boston Scientific Corporation

Observational

12,500

Modena, Roma

2021-03-31

Active, closed

A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease

NCT04711252ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Anastrozole·Palbociclib

AstraZeneca

Phase 3

1,371

Bergamo, Florence, Milan, Modena, Naples, Novara, Padova, Parma

2021-01-28

Active, closed

A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

NCT04204616Prurigo Nodularis

DrugNemolizumab

Galderma R&D

Phase 3

500

Catania, Chieti, Genova, L’Aquila, Modena, Naples, Parma, Perugia

2021-01-11

Active, closed

Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)

NCT04624204Small Cell Lung Cancer

DrugsOlaparib·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

672

Modena, Florence, Verona, Brescia, Milan, Padova, Roma

2020-12-08

Active, closed

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

NCT04644068Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer

DrugsSaruparib·Camizestrant·Dato-DXd·Trastuzumab deruxtecan

AstraZeneca

Phase 1/2

702

Milan, Modena, Naples, Padova, Roma

2020-11-12

Active, closed

RADIANT: A Study of Radium-223 Dichloride (Xofigo) vs Enzalutamide or Abiraterone (ARPIs, Androgen Receptor Pathway Inhibitors) in Patients With Prostate Cancer That Has Spread to the Bones (mCRPC, Metastatic Castration-Resistant Prostate Cancer)

NCT04597125Metastatic Castrate Resistant Prostate Cancer (mCRPC)

Bayer

Phase 4

654

Ferrara, Modena, Parma, Aviano, Rome, Genoa, Milan, Alessandria

2020-11-09

Active, closed

Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

NCT04590963Squamous Cell Carcinoma of the Head and Neck

DrugsMonalizumab·Erbitux·Cetuximab

AstraZeneca

Phase 3

370

Brescia, Candiolo, Florence, Milan, Modena, Naples, Padova

2020-10-02

Active, closed

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)

NCT04526665Primary Biliary Cirrhosis

DrugElafibranor

Ipsen

Phase 3

161

Modena, Bologna, Milan, Monza, Padova, Palermo

2020-09-24

Active, closed

Linerixibat Long-term Safety, and Tolerability Study

NCT04167358Cholestasis

GlaxoSmithKline

Phase 3

242

Milan, Modena, Monza, Naples, Negrar Verona, Padova, Palermo, Roma

2020-07-14

Active, closed

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

NCT04380636Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

DrugsParaplatin·Taxol·Olaparib·Etoposide

Merck Sharp & Dohme LLC

Phase 3

870

Torrette, Rome, Rozzano, Florence, Lecce, Milan, Modena, Udine

2020-07-06

Active, closed

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

NCT04273945Pulmonary Arterial Hypertension

DrugMacitentan

Actelion

Phase 3

935

Milan, Modena, Nuoro, Pavia, Pisa, Roma

2020-06-30

Active, closed

Patient-Reported Outcomes in PHiladelphia-nEgative Cytogenetic mYeloproliferative Neoplasms (PROPHECY).

NCT04378855Myeloproliferative Neoplasm

Gruppo Italiano Malattie EMatologiche dell'Adulto

Observational

572

Alessandria, Asti, Bari, Bologna, Cagliari, Florence, Milan, Modena

2020-05-29

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)

NCT04241185Urinary Bladder Neoplasms

DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda

Merck Sharp & Dohme LLC

Phase 3

520

Bari, Rome, Milan, Florence, Modena, Naples, Province of Macerata

2020-05-19

Active, closed

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer

NCT04305496Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Fulvestrant

AstraZeneca

Phase 3

818

Bergamo, Candiolo, Catanzaro, Livorno, Meldola, Milan, Modena, Naples

2020-04-16

Active, closed

Atezolizumab Versus Atezolizumab Plus Bevacizumab as First Line in NSCLC Patients (BEAT)

NCT03896074Non-small-cell Lung Cancer Patients

DrugsAtezolizumab·Bevacizumab

Fondazione Ricerca Traslazionale

Phase 2

206

Ponderano, Lecco, Catania, Grosseto, Province of Macerata, Monza, Modena, Piacenza

2020-03-02

Recruiting

Inspiratory Effort in COVID-19

NCT04666246Acute Respiratory Failure, Covid19

University of Modena and Reggio Emilia

Observational

Modena

2020-03-01

Active, closed

A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

NCT04195750Carcinoma, Renal Cell

DrugsBelzutifan·Everolimus

Merck Sharp & Dohme LLC

Phase 3

755

Verona, Arezzo, Bari, Bologna, Milan, Modena, Padova, Pavia

2020-02-27

Active, closed

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

NCT04170283B-cell Malignancies

DrugsZanubrutinib·Tislelizumab

BeOne Medicines

Phase 3

955

Bologna, Meldola, Milan, Modena, Novara, Ravenna, Roma, Terni

2020-01-16

Recruiting

Terumo Aortic Global Endovascular Registry

NCT04246463Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery

Vascutek Ltd.

Observational

1,000

Bari, Bolzano, Cagliari, Careggi, Catania, Modena, Siena, Turin

2019-12-17

Recruiting

High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

NCT04221035High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy

DrugsDinutuximab Beta·Vindesine·Cyclophosphamid·Thiotepa

Gustave Roussy, Cancer Campus, Grand Paris

Phase 3

800

Bari, Brescia, Catania, Florence, Genova, Modena, Parma, Pavia

2019-11-05

Active, closed

A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer

NCT04036682Non Small Cell Lung Cancer, EGFR Exon 20 Mutation

DrugZipalertinib

Cullinan Therapeutics Inc.

Phase 1/2

284

Careggi, Marche, Meldola, Milan, Modena, Monza, Ravenna

2019-10-31

Active, closed

Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

NCT04058756Advanced Solid Tumors

DrugSpartalizumab

Novartis Pharmaceuticals

Phase 1

120

Milan, Rozzano, Modena, Aviano, Siena, Naples

2019-10-30

Active, closed

An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis

NCT03950232Ulcerative Colitis

DrugEtrasimod

Pfizer

Phase 3

896

Castellana Grotte, Brescia, Milan, San Donato Milanese, Rho, Modena, Florence, Negrar(vr)

2019-09-05

Recruiting

InheriteD brEast caNcer iTalian regIsTrY A Retrospective-prospective Observational Cohort Study to Evaluate Cancer Prevention Strategies in Women With a Deleterious Mutation in BRCA1-2

NCT05835739Breast Cancer

Centro di Riferimento Oncologico - Aviano

Observational

Aviano, Genova, Messina, Milan, Modena, Naples, Reggio Emilia, Roma

2019-08-27

Active, closed

Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

NCT03937219Renal Cell Carcinoma

DrugsCabozantinib·Yervoy·Ipilimumab·Opdivo

Exelixis

Phase 3

855

Meldola, Faenza, Arezzo, Modena, Padova, Pavia, Perugia, Terni

2019-06-25

Active, closed

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

NCT03767244Prostatic Neoplasms

DrugApalutamide

Janssen Research & Development, LLC

Phase 3

2,517

Abano Terme, Acquaviva delle Fonti, Bassano del Grappa, Brescia, Chieti, Florence, Milan, Modena

2019-06-11

Active, closed

A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy

NCT03675308Psoriatic Arthritis

DrugsSkyrizi·Risankizumab

AbbVie

Phase 3

964

Modena, Ancona, Catania, Rome, Verona

2019-03-25

Recruiting

Role of Cardiac AngioMR in Diagnosis of Cardiac and Vascular Anomalies in Adult Patients with Turner Syndrome

NCT06178887Anomaly Heart, Turner Syndrome

Azienda Ospedaliero-Universitaria di Modena

Observational

Modena

2019-01-08

Active, closed

A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy

NCT03762850Immunoglobulin A Nephropathy

DrugsSparsentan·Irbesartan·Dapagliflozin

Travere Therapeutics, Inc.

Phase 3

406

Ranica, Milan, Bari, Catania, Catanzaro, Lecco, Modena, Pavia

2018-12-11

Active, closed

Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)

NCT03707743Aortic Dissection

IRCCS San Raffaele

Observational

200

Lecco, Milan, Modena, Roma, Florence, Sassari, Verona

2018-10-30

Active, closed

Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer

NCT03595592Invasive Breast Cancer

DrugsPerjeta·Herceptin·Tecentriq·Pertuzumab

Fondazione Michelangelo

Phase 3

650

Bergamo, Brindisi, Faenza, Genova, Meldola, Milan, Modena, Negrar

2018-09-07

Active, closed

A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy in Adults With Gastric Cancer.

NCT03504397Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

DrugsZolbetuximab·Folinic acid·Fluorouracil·Oxaliplatin

Astellas Pharma Global Development, Inc.

Phase 3

565

Meldola, Monza, Vicenza, Ancona, Bergamo, Cremona, Milan, Modena

2018-06-21

Active, closed

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

NCT03383458Hepatocellular Carcinoma, Liver Cancer

DrugsOpdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

545

Messina, Bologna, Florence, Meldola, Milan, Modena, Monserrato, Naples

2018-04-18

Active, closed

Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)

NCT03301506Primary Biliary Cirrhosis

DrugSeladelpar

Gilead Sciences

Phase 3

340

Modena, Palermo, Rozzano

2017-12-12

Recruiting

Scaffold in Emilia Romagna and in the MAGIC Network

NCT03327961Coronary Artery Disease

University Hospital of Ferrara

Observational

1,111

Agrigento, Treviglio, Bologna, Savigliano, Cona, Forlì, Modena, Parma

2017-12-02

Active, closed

A Study Comparing Zanubrutinib With Bendamustine Plus Rituximab in Participants With Previously Untreated CLL or SLL

NCT03336333Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsVenclyxto·Bendamustine·Venclexta·Zanubrutinib

BeiGene

Phase 3

590

Brescia, Meldola, Milan, Modena, Ravenna, Roma, Terni, Torino

2017-10-31

Active, closed

A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)

NCT03148418Cancer

DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab

Hoffmann-La Roche

Phase 3

382

Naples, Modena, Rome, Genoa, Milan, Monza, Novara, Orbassano

2017-09-20

Active, closed

Savolitinib vs. Sunitinib in MET-driven PRCC.

NCT03091192Carcinoma, Carcinoma, Renal Cell, Kidney Neoplasms, Urologic Neoplasms

DrugsSavolitinib·Sunitinib

AstraZeneca

Phase 3

Arezzo, Meldola, Milan, Modena, Orbassano, Pavia, Roma

2017-07-25

Active, closed

A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL

NCT02970318Chronic Lymphocytic Leukemia

DrugsIdelalisib·Acalabrutinib·Bendamustine·Rituximab

Acerta Pharma BV

Phase 3

310

Aviano, Bergamo, Brescia, Florence, Genova, Meldola, Milan, Modena

2017-02-02

Recruiting

Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure

NCT03826797Acute Respiratory Failure

University of Modena and Reggio Emilia

Observational

300

Modena

2016-10-16

Active, closed

Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma

NCT02811861Renal Cell Carcinoma

DrugsSunitinib·Everolimus·Lenvatinib·Pembrolizumab

Eisai Inc.

Phase 3

1,069

Faenza, Arezzo, Bologna, Genova, Lecce, Meldola, Milan, Modena

2016-10-13

Active, closed

A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy

NCT02655016Ovarian Neoplasms

DrugNiraparib

Tesaro, Inc.

Phase 3

733

Lecce, Milan, Modena, Naples

2016-07-11

Active, closed

Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors

NCT02715284Neoplasms

DrugDostarlimab

Tesaro, Inc.

Phase 1

729

Milan, Modena, Naples, Roma, Verona

2016-03-07

Active, closed

Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib Treatment in a Novartis-sponsored Study

NCT02584933ALK Positive Malignancies

DrugCeritinib

Novartis Pharmaceuticals

Phase 4

233

Bergamo, Bologna, Brescia, Meldola, Monza, Milan, Rozzano, Modena

2015-12-11

Active, closed

Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

NCT02477696Chronic Lymphocytic Leukemia

DrugsIbrutinib·Acalabrutinib

Acerta Pharma BV

Phase 3

533

Bologna, Cagliari, Cona, Florence, Meldola, Milan, Modena, Ravenna

2015-07-28

Active, closed

Study of Safety and Efficacy of Ceritinib in Combination With Nivolumab in Patients With ALK-positive Non-small Cell Lung Cancer

NCT02393625ALK-positive NSCLC

DrugsCeritinib·Nivolumab

Novartis Pharmaceuticals

Phase 1

Milan, Modena

2015-05-27

Active, closed

Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients

NCT02362503HIV Infections

ViiV Healthcare

Phase 3

371

Milan, Modena, Monza MB, Roma, Torino

2015-02-23

Active, closed

Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer

NCT02032823Breast Cancer

DrugOlaparib

AstraZeneca

Phase 3

1,837

Bergamo, Bologna, Bolzano, Castellanza Varese, Lecce, Legnago, Milan, Modena

2014-04-22

Active, closed

Journey II BCS EU Observational Trial

NCT02211794Degenerative Joint Disease

Smith & Nephew Orthopaedics AG

Observational

179

Modena

2014-02-05

Active, closed

Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy

NCT01874353Platinum Sensitive, BRCA Mutated, Relapsed Ovarian Cancer, Following Complete or Partial Response to Platinum Based Chemotherapy

DrugOlaparib

AstraZeneca

Phase 3

327

Milan, Modena, Naples, Padova, Roma

2013-09-03

Active, closed

Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia - Long Term Follow-up

NCT01357772Carcinoma, Intraductal, Noninfiltrating, Recurrence, Local Neoplasm, Breast Neoplasms, Atypical Hyperplasia

DrugTamoxifen

Andrea DeCensi

Phase 3

500

Tortona, Meldola, Carpi, Bari, Catanzaro, Genoa, Milan, Modena

2008-11-12

By invitation

EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV

NCT02699736HIV, Hepatitis B, Hepatitis C, AIDS

Copenhagen University Hospital, Rigshospitalet

Observational

23,000

Bergamo, Milan, Modena, Naples, Rome

1994-01

Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 10 October 2026. https://priyalifescience.com/clinical-trials-italy/city/modena

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,778 studies in total at the last sync on 08 Oct 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 257 of those studies with a site in Modena.

How many clinical trials are recruiting in Modena?

136 of the 257 studies on this page are recruiting new participants as of the 08 Oct 2026, 03:19 UTC sync. A further 11 have not yet opened recruitment, 104 are active but closed to new participants, and 6 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Modena), 257 studies
Phase	Studies	Recruiting	Share
Phase 3	122	48	47.5%
Observational	61	46	23.7%
Phase 2	27	15	10.5%
Not applicable	24	17	9.3%
Phase 1/2	8	5	3.1%
Phase 2/3	6	3	2.3%
Phase 4	5	2	1.9%
Phase 1	4	0	1.6%

Most active sponsors

Lead sponsors with the most studies (Modena)
Lead sponsor	Studies	Recruiting
AstraZeneca	24	13
Novartis Pharmaceuticals	12	3
University of Modena and Reggio Emilia	11	9
Azienda Ospedaliero-Universitaria di Modena	9	7
Hoffmann-La Roche	8	4
Azienda USL Reggio Emilia - IRCCS	7	5
IRCCS Azienda Ospedaliero-Universitaria di Bologna	6	6
Merck Sharp & Dohme LLC	6	1
Eli Lilly and Company	5	3
Boehringer Ingelheim	4	3

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.