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Clinical Trials in Italy / NCT07373288
Recruiting Observational

HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis

NCT07373288 · tracked via the Priya Life Science Italy tracker
Sponsor
University of Modena and Reggio Emilia
Phase
Observational
Started
2023-07-01
Last updated
2026-02-04

Condition(s) studied

Fibrosis, Pulmonary

Investigational drug(s) / intervention(s)

Biopsy

Biopsy: This is a non-therapeutic, observational sampling study. Procedures include: Lung tissue sampling via: Surgical biopsy Transbronchial cryobiopsy Explanted lungs from transplant patients Blood sampling for exosome analysis

Study summary

This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.

Eligibility

Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria: * Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis * Availability of fresh lung tissue from biopsy or lung explant * Signed informed consent for research use of biological material and data Exclusion Criteria: \- Refusal to sign informed consent

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Azienda Ospedaliero Universitaria Policlinico di Modena Modena Italy Recruiting

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07373288 on ClinicalTrials.gov ↗ ← All trials in Italy