Clinical trial register · Italy

Clinical Trials in Bologna, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6778 matching records held by the registry are in this view. Synced 08 Oct 2026, 03:19 UTC

6778

Studies in scope

all four open statuses

4069

Recruiting now

open to new participants

1018

Lead sponsors

across recruiting studies

Top sites

Milan 2843 Bologna 1305 Roma 1274 Naples 984 Rome 967

Trials with a site in Bologna

Status

Study

Lead sponsor

Phase

Enrol

Sites in Italy

Start

Recruiting

A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT06290141Chronic Inflammatory Demyelinating Polyneuropathy

DrugsRiliprubart·IVIG

Sanofi

Phase 3

160

Milan, Rozzano, Padua, Bologna

2024-08-21

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

NCT06461897Atopic Dermatitis

DrugsUpadacitinib·Dupilumab

AbbVie

Phase 3

675

Rome, Bologna

2024-08-19

Recruiting

A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

NCT06435429Metastatic HER2-positive Breast Cancer

DrugsZanidatamab·Eribulin·Vinorelbine·Trastuzumab

Jazz Pharmaceuticals

Phase 3

550

Aviano, Bergamo, Bologna, Milan, Modena, Monza, Padova, Pavia

2024-08-13

Recruiting

Cryopreserved Ovarian Tissue Transplantation in Patients Who Have Survived Sarcomas and Hematological Tumors

NCT06829654Sarcomas, Haematological Malignancies

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2024-08-12

Active, closed

A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms

NCT06313593Myeloproliferative Neoplasms

Incyte Corporation

Phase 1

Bologna, Florence, Milan

2024-08-08

Active, closed

A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME

NCT06571045Diabetic Macular Edema (DME)

DrugsRestoret·Lucentis·Ranibizumab

EyeBiotech Ltd.

Phase 2/3

984

Bologna, Florence, Milan, Roma, Rome, Udine

2024-08-07

Active, closed

Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

NCT06531109Alopecia Areata

DrugRitlecitinib

Pfizer

Observational

450

Bari, Rozzano, Bologna, Catania, Roma, Rome

2024-08-07

Recruiting

intErnet-based iNterventions FOR Cardiac arrEst suRvivors

NCT06395558Cognitive Impairment, Depression, Anxiety, Cardiac Arrest, Quality of Life

Azienda Usl di Bologna

Not applicable

106

Bologna, Imola

2024-08-05

Recruiting

Peripheral Mononuclear Cells to Screen, Monitor and Stratify the Population at Risk of Osteoporosis and Fractures

NCT06551155Osteoporosis, Osteopenia, Osteoporosis Fracture

Istituto Ortopedico Rizzoli

Observational

120

Bologna, Catania

2024-08-05

Recruiting

Immunological Senescence Phenotype as a Resistance Profile to Pembrolizumab in Patients With Relapsed/Refractory Hodgkin's Lymphoma

NCT06733987Hodgkin Lymphoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2024-08-01

Recruiting

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

NCT06380751Advanced Breast Cancer

DrugsSaruparib·Camizestrant·Exemestane·Anastrozole

AstraZeneca

Phase 3

788

Bergamo, Bologna, Milan, Modena, Naples, Padova, Reggio Emilia, Rome

2024-08-01

Active, closed

Evaluation of the Performance and Safety of Hyalo Gyn® Gel Compared to Placebo in Postmenopausal Breast Cancer Survivors

NCT06922136Vulvo Vaginal Atrophy

Fidia Farmaceutici s.p.a.

Not applicable

156

Bologna, Florence, Padova, Pavia, Roma, Torino, Milan

2024-08-01

Recruiting

The Role of Ceus in the Characterization of Focal Liver Lesions Indeterminate to Second-level Methods

NCT06876805Focal Liver Lesion

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2024-08-01

Active, closed

A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy

NCT06440967Hot Flashes

DrugsFezolinetant·Tamoxifen

Astellas Pharma Global Development, Inc.

Phase 3

982

Bologna, Genova, Milan, Mirano, Pavia, Reggio Emilia, Terni

2024-07-31

Active, closed

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

NCT06517758Generalized Myasthenia Gravis

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

146

Bologna, Florence, Genova, Milan, Palermo, Roma, Orbassano

2024-07-31

Recruiting

Utility of Adjusting Chemotherapy Dose & Dosing Schedule With the SALVage Weekly Dose-dense Regimen in Patients With Poor Prognostic OVARian Cancers Based on the Tumor Unfavorable Primary Chemosensitivity and Incomplete Debulking Surgery

NCT06476184Ovarian Cancer

DrugsPaclitaxel·Carboplatin

ARCAGY/ GINECO GROUP

Phase 3

250

Alessandria, Bologna, Florence, Lecco, Milan, Venice

2024-07-30

By invitation

Long-term Safety and Tolerability of BHV-7000

NCT06443463Focal Epilepsy

DrugOpakalim

Biohaven Therapeutics Ltd.

Phase 2

660

Chieti, Catanzaro, Naples, Bologna, Rome, Genoa, Milan, Pavia

2024-07-30

Recruiting

Pubertal Development in Patients with RASopathies

NCT06776380RASopathy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2024-07-25

Active, closed

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

NCT06459180Cervical Cancer

DrugsTisotumab Vedotin·Vinorelbine·Topotecan·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

686

Bologna, Milan, Monza, Rozzano, Turin, Brescia, Catania, Naples

2024-07-24

Active, closed

A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)

NCT06355531Progressive Supranuclear Palsy

Ferrer Internacional S.A.

Phase 2

241

Bologna, Padova, Pisa, Roma, Salerno

2024-07-23

Active, closed

Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia

NCT06347003Severe Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

446

Rozzano, Palermo, Bologna, Brescia, Milan, Roma

2024-07-22

Recruiting

Real World Pediatric Oncology Rehabilitation in Italy ( ReWori )

NCT07368582Pediatric Cancer, Pediatric Cancer Patients, Pediatric Oncology, Rehabilitation

Associazione Italiana Ematologia Oncologia Pediatrica

Observational

249

Bergamo, Bologna, Bolzano, Bosisio Parini, Brindisi, Catania, Conegliano, Florence

2024-07-19

Recruiting

Digital diagnoSis of Cardiac sOUNd in peDiatric Patients [DI-SOUND Study]

NCT07542509Cardiac Disease, Auscultation of Heart, Machine Learning

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,000

Bologna, Milan, Roma, Naples

2024-07-18

Recruiting

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

NCT06226883Inflammatory Bowel Diseases, Crohn's Disease

DrugZotemtegrast

Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

Phase 2

385

Bologna, Brescia, Catanzaro, Milan, Negrar, Padova, Roma, Rozzano

2024-07-18

Active, closed

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

NCT06456346Essential Thrombocythemia

DrugsBomedemstat·Hydroxyurea

Merck Sharp & Dohme LLC

Phase 3

300

Florence, Alessandria, Bologna, Milan, Pavia, Roma, Varese

2024-07-16

Recruiting

Pulmonary Thromboembolism in Cancer Patients: Early Rule-out From the Emergency Department

NCT06761144Pulmonary Thromboembolisms

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

500

Bologna

2024-07-13

Recruiting

PK/PD Analysis of Ceftazidime/Avibactam or Cefiderocol With or Without Fosfomycin for the Treatment of Difficult To-treat Gram-negative Infections

NCT06651047Gram Negative Infection, Antimicrobial Resistance (AMR)

University of Bologna

Observational

120

Bologna, Catania, Milan, Padova, Palermo, Rome, Siena, Turin

2024-07-09

Recruiting

Polyspecific Antibodies in Lymphoproliferative T-cell Disorders

NCT06495723Peripheral T Cells Lymphoma (PTCL)

Xenothera SAS

Phase 1/2

Naples, Bologna, Milan

2024-07-09

Recruiting

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

NCT06127407Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

DrugIvosidenib

Servier Bio-Innovation LLC

Phase 3

136

Bologna, Milan, Orbassano, Padova, Palermo, Prato, Roma

2024-07-09

Recruiting

A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).

NCT05895136Liver Cirrhosis, Decompensated Cirrhosis of Liver, Acute on Chronic Liver Failure (ACLF)

DrugsHuman albumin·Enoxaparin

European Foundation for Study of Chronic Liver Failure

Phase 2

Bologna, Turin

2024-07-01

Recruiting

Master Framework For Relapse or Refractory Acute Myeloid Leukemia

NCT06459024Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Observational

4,000

Bologna, Brindisi, Brescia, Cuneo, Como, Cremona, Ferrara, Genova

2024-06-28

Recruiting

Assessment of Infection Activity in Travelers and Migrants Diagnosed With Chronic Schistosomiasis

NCT06873308Schistosomiasis

IRCCS Sacro Cuore Don Calabria di Negrar

Not applicable

278

Bologna, Negrar, Florence

2024-06-28

Recruiting

A Registry-study of ELZONRIS in Participants With BPDCN

NCT07785154Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

DrugTagraxofusp

Stemline Therapeutics, Inc.

Observational

Alessandria, Bologna, Catania, Cuneo, Ferrara, Florence, Genova, Milan

2024-06-26

Recruiting

Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

NCT06463587Generalized Myasthenia Gravis

DrugCladribine

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Phase 3

264

Bergamo, Bologna, Genova, Milan, Pavia, Rome, Treviso

2024-06-25

Recruiting

How Complexity and Multiple Illnesses Affect Hospitalized Patients' Health: a Multicenter Study

NCT06872632Complexity and Multiple Illnesses of Adult Hospitalized Internal Medicine Patient

Società Italiana di Medicina Interna

Observational

2,326

Bari, Bologna, Brescia, Ferrara, Florence, Messina, Milan, Modena

2024-06-24

Recruiting

Active Informed Consent: a New Solution to Improve and Objectively Test the Patient Understanding of Complex Surgical Procedures Proposals

NCT06059599Spine Disease, Urologic Diseases

Istituto Ortopedico Rizzoli

Not applicable

300

Bologna

2024-06-19

Active, closed

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

NCT06388733Glioblastoma, GBM, Brain Neoplasms, Adult, Malignant, Brain Tumor

DrugsTemodar·Niraparib·Temozolomide

Ivy Brain Tumor Center

Phase 3

450

Bologna, Florence, Milan, Rozzano, Naples, Padova, Rome, Torino

2024-06-19

Recruiting

Study of the Characteristics of the Vascular Wall in Pediatric Age

NCT06774586Cardiovascular Diseases

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

500

Bologna

2024-06-18

Active, closed

A Study of Rozanolixizumab in Pediatric Study Participants With Moderate to Severe Generalized Myasthenia Gravis

NCT06149559Generalized Myasthenia Gravis

DrugRozanolixizumab

UCB Biopharma SRL

Phase 2/3

Bologna, Milan, Naples

2024-06-14

Recruiting

Prenatal Ultrasonographic Assessment of Fetal Thyroid in Patients With Thyroid Pathology

NCT06788821Thyroid Disease Pregnancy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

440

Bologna, Trento

2024-06-12

Recruiting

Clinical-MRI Evaluation in Patients Undergoing Subtalar Arthrorisis With Reabsorbable Endorthesis Implant in PLLA

NCT06525532Lower Limb Deformity

Istituto Ortopedico Rizzoli

Observational

Bologna

2024-06-12

Active, closed

Spine Surgery for Lenke 1 Adolescent Idiopathic Scoliosis

NCT06396286Scoliosis, Spine Deformity, Adolescent Idiopathic Scoliosis

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2024-06-12

Recruiting

Development of a Predictive Model of Fetal PH At Birth from Novel Variables Derived from Cardiotocographic Tracing

NCT06720363Pregnancies At Increased Risk of Preterm Birth

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

5,000

Bologna

2024-06-07

Recruiting

Calibr-Ì: Comparative Evaluation of Phantomless Calibration Methods to Quantify Bone Mineral Density for Opportunistic Analysis of CT Scans

NCT06454617Osteoporosis

Istituto Ortopedico Rizzoli

Observational

100

Bologna

2024-06-06

Recruiting

Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

NCT06479135Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis, Primary Myelofibrosis

DrugsNavtemadlin·Jakavi·Ruxolitinib

Kartos Therapeutics, Inc.

Phase 3

600

Alessandria, Ancona, Bologna, Brescia, Catania, Florence, Forlì, Milan

2024-06-03

Recruiting

Virtual Reality for Reducing Anxiety in Pediatric Orthopedic Surgery

NCT06604364Virtual Reality

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2024-06-03

Recruiting

Italian PheNotypes Obstructive Sleep Apnea Study

NCT06872242Sleep Apnea

Istituto Auxologico Italiano

Observational

5,000

Acri, Ancona, Bari, Bergamo, Bologna, Cagliari, Catania, Corigliano-Rossano

2024-06-01

Recruiting

Clinical and Radiological Evaluation Over 10 Years After Bilateral Subtalar Arthrorisis Surgery With Endorthesis and Calcaneal Stop for the Correction of Pediatric Flatfoot

NCT07569835Flat Foot Acquired Bilateral (Pes Planus)

Istituto Ortopedico Rizzoli

Observational

Bologna

2024-05-30

Recruiting

Analysis of Intramedullary Nail and Prosthetic Reconstruction After Surgical Treatment of Bone Metastases of Proximal Femur

NCT06918860Bone Metastases

Costantino Errani

Observational

600

Bologna

2024-05-30

Recruiting

Image-Guided Surgery In The Treatment Of Rectal Cancer (AR_CRC)

NCT06805045Rectum Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2024-05-29

Active, closed

A Study of JNJ-88998377 for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

NCT06470438Lymphoma, Non-Hodgkin, Refractory B-Cell NHL, Relapsed B-cell NHL

Janssen Research & Development, LLC

Phase 1

Bologna

2024-05-28

Recruiting

Efficacy and Safety of Frontline Tislelizumab in Patients With de Novo Hodgkin Lymphoma Unsuitable for Standard Frontline Chemotherapy

NCT05977673Hodgkin Lymphoma

DrugTislelizumab

Fondazione Italiana Linfomi - ETS

Phase 2

Alessandria, Aviano, Bologna, Brescia, Milan, Naples, Novara, Palermo

2024-05-23

Recruiting

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

NCT06351631Thrombocythemia, Essential, Primary Myelofibrosis, Myelofibrosis, Post-polycythemia Vera Myelofibrosis

DrugBomedemstat

Merck Sharp & Dohme LLC

Phase 3

400

Florence, Alessandria, Bologna, Varese

2024-05-23

Active, closed

Comparison Between Rituximab Plus Zanubrutinib Versus Rituximab Monotherapy in Untreated SMZL Patients

NCT05735834Splenic Marginal Zone Lymphoma

DrugsTruxima·Zanubrutinib·Rituximab

International Extranodal Lymphoma Study Group (IELSG)

Phase 3

122

Bari, Bologna, Brescia, Catania, Meldola, Milan, Novara, Palermo

2024-05-21

Recruiting

Implementation of the Methylome in the Characterization of Solid Tumors

NCT07268066Solid Tumor Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

180

Bologna

2024-05-21

Recruiting

Validation of a Machine Learning Model Based on MR for the Prediction of Prostate Cancer

NCT06773598Prostate Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,100

Bologna

2024-05-21

Recruiting

Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis

NCT06414954Myasthenia Gravis, Myasthenia Gravis, MuSK

NMD Pharma A/S

Phase 2

Bergamo, Bologna, Genova, Milan, Naples, Pisa, Roma

2024-05-16

Active, closed

Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

NCT06309966Focal Epilepsy

DrugOpakalim

Biohaven Therapeutics Ltd.

Phase 2/3

390

Chieti, Catanzaro, Naples, Bologna, Rome, Genoa, Milan, Pavia

2024-05-13

Recruiting

Legs Dysmetria in Total Hip Replacement: Does Hip Approacches and Navigation Decrease the Risk?

NCT06506201Hip Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

136

Bologna

2024-05-13

Active, closed

A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis

NCT06407934Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 3

1,541

Milan, Rozzano, Rome, Bologna, Catania, L’Aquila, Pisa, Vicenza

2024-05-08

Recruiting

Poor Sleep During Pregnancy as Risk Factor for Post-partum Stress and Mental Health

NCT06379074Postpartum Depression, Insomnia, Stress

University of Rome G. Marconi

Not applicable

114

Bologna, Rome

2024-05-06

Active, closed

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

NCT06383390Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

DrugRetatrutide

Eli Lilly and Company

Phase 3

10,000

Bologna, Ferrara, Genova, Milan, Palermo, Perugia, Pisa, Roma

2024-04-30

Recruiting

Proximal Femur Reconstruction Following Resection of Primary Bone Tumors: Analysis of the Clinical and Radiographic Results

NCT06486506Bone Tumor, Bone Cancer

Costantino Errani

Observational

150

Bologna

2024-04-29

Recruiting

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)

NCT05485961End Stage Kidney Disease

DrugClazakizumab

CSL Behring

Phase 2/3

3,110

Bologna, Brescia, Cagliari, Caserta, Catania, Ferrara, Florence, Foggia

2024-04-27

Active, closed

Heart Failure Patient Management and Interventions Using Continuous Patient Monitoring Outside Hospitals and Real-world Data

NCT07008729Chronic Heart Failure, Heart Transplant Recipient, Left Ventricular Assist Device

Puerta de Hierro University Hospital

Not applicable

390

Bologna

2024-04-24

Recruiting

Prospective, Multicentre, Randomized, Controlled, Cross-over Study on the Safety and Performance of the Biologic Fusion Option of DialogiQ Compared to Haemodialysis Without Biologic Fusion in Hypotension Prone Patients on Maintenance Haemodialysis

NCT06376968Renal Dialysis

B.Braun Avitum AG

Not applicable

Bologna

2024-04-22

Recruiting

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

NCT05980806Myelofibrosis, Moderate Thrombocytopenia, Mild Thrombocytopenia

DrugsMomelotinib·Pacritinib·Selinexor·Ruxolitinib

Karyopharm Therapeutics Inc

Phase 2

Milan, Orbassano, Torino, Bologna, Genova, Meldola, Novara, Pavia

2024-04-22

Recruiting

Risk Factors for Non-response to Hormonal Medical Therapy in Patients With Endometriosis

NCT06413381Endometriosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

250

Bologna

2024-04-19

Recruiting

Observational Cohort Study of Adult Patients With Congenital Heart Disease

NCT06769529Adult Congenital Heart Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

2,000

Bologna

2024-04-18

Active, closed

Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients

NCT06408935Crohn's Disease

DrugsTremfya·Guselkumab

Janssen-Cilag Ltd.

Phase 3

120

Bologna, Milan, Naples, Pontedera Pisa, Rho, Roma, Rozzano, San Giovanni Rotondo

2024-04-17

Recruiting

Targeting Acute Myeloid Leukemia Immunosuppressive Microenvironment by combinedIDO1 Inhibition and PD-1 Blockade

NCT06874257AML (Acute Myelogenous Leukemia)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2024-04-17

Recruiting

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

NCT06312176Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

1,200

Meldola, Aviano, Milan, Rozzano, Bologna, Genova, Roma

2024-04-14

Recruiting

Comparison of Levothyroxine Formulations in the Treatment of Congenital Hypothyroidism

NCT06724224Congenital Hypothyroidism

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

120

Bologna

2024-04-08

Active, closed

HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array

NCT05952648HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Not applicable

126

Bologna, Florence, Modena, Roma

2024-04-03

Active, closed

A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

NCT06329401Pulmonary Fibrosis, Progressive Pulmonary Fibrosis, Pulmonary Fibrosis Secondary to Systemic Sclerosis, Pulmonary Fibrosis, Interstitial Lung Disease

DrugPirfenidone

Avalyn Pharma Inc.

Phase 2

375

Torrette, Naples, Bologna, Venezia, Pavia, Milan, Rozzano, Catania

2024-04-03

Recruiting

Comparison Diagnostic Tests for the Diagnosis of CYTOmegalovirus Organ Disease in Patients With intestinalBOweL Diseases

NCT06793124Cytomegalovirus (CMV), Inflammatory Bowel Disease (IBD)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

200

Bologna

2024-04-02

Recruiting

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion

NCT06158854Immunoglobulin Light Chain (AL) Amyloidosis

DrugEtentamig

AbbVie

Phase 1/2

Bologna, Pavia

2024-04-01

Active, closed

A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.

NCT06268873Chronic Kidney Disease and Hypertension

DrugBaxdrostat/dapagliflozin

AstraZeneca

Phase 3

2,554

Bologna, Catanzaro, Chiavari, Desio, Milan, Naples, Parma, Rozzano

2024-03-29

Active, closed

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

NCT06254950Ulcerative Colitis

DrugZasocitinib

Takeda

Phase 2

213

Bologna, Milan, Palermo, Rome, Rozzano

2024-03-29

Active, closed

Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

NCT06291376Immunoglobulin A Nephropathy, IgAN

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Phase 3

584

Agrigento, Bologna, Brescia, Cagliari, Florence, Milan, Padova, Parma

2024-03-29

Recruiting

Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars

NCT06375941Angiosarcoma

Italian Sarcoma Group

Observational

250

Rozzano, Aviano, Orbassano, Bari, Bologna, Florence, Genova, Milan

2024-03-29

Active, closed

Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06290934Ulcerative Colitis

Gilead Sciences

Phase 2

228

Bologna, Cagliari, Catanzaro, Milan, Negrar, Padova, Palermo, Roma

2024-03-27

Recruiting

A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia (CARDINAL)

NCT06163430Chronic Myeloid Leukemia, Chronic Phase, Chronic Myeloid Leukemia

Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 1/2

180

Bologna, Milan, Monza

2024-03-26

Recruiting

Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera

NCT06093672Polycythemia Vera

DrugHydroxyurea

Italfarmaco

Phase 3

220

Bari, Reggio Calabria, Bologna, Meldola, Reggio Emilia, Udine, Rome, Bergamo

2024-03-26

Recruiting

Evaluating Efficacy and Tolerability of Anticancer Drug Therapies for the Treatment of Gynecologic and Breast Cancers

NCT06800612Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Cancer Metastatic, Ovarian Cancer, Cervical Carcinoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2024-03-22

Recruiting

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

NCT06256588Neoplasms, Head and Neck

DrugDostarlimab

GlaxoSmithKline

Phase 3

864

Bolzano, Bologna, Milan, Naples, Pavia, Prato, Roma, Rozzano MI

2024-03-21

Recruiting

Role of RPL8 Protein Alterations in High-grade Serous Ovarian Carcinoma

NCT06777082High Grade Serous Ovarian Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

150

Bologna

2024-03-20

Recruiting

Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study

NCT05904119First Progression of Glioblastoma

DrugLomustine

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

411

Bologna, Legnago, Milan, Padova, Roma

2024-03-15

Recruiting

Epidemiology of Acute Otomastoiditis in Pediatric Age

NCT06767267Otomastoiditis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

350

Bologna

2024-03-13

Recruiting

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

NCT05923073Crohn's Disease

DrugsTremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

120

Alessandria, Bergamo, Bologna, Florence, Milan, Roma

2024-03-13

Recruiting

Idiopathic Central Precocious Puberty and Associated Neurodevelopmental Syndromes and Pathologies: Evaluation of Frequency and Comparison of Diagnostic and Developmental Characteristics

NCT06720844Central Precocious Puberty (CPP)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

300

Bologna

2024-03-13

Recruiting

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

NCT05509777Crohn's Disease

DrugMirikizumab

Eli Lilly and Company

Phase 3

Alessandria, Bergamo, Bologna, Florence, Milan, Roma

2024-03-13

Recruiting

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

NCT05646381Aortic Stenosis

DrugPelacarsen

Novartis Pharmaceuticals

Phase 2

502

Ancona, Bergamo, Bologna, Brescia, Caserta, Cona, Pozzilli, Milan

2024-03-07

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

NCT06233461Crohn's Disease

DrugZasocitinib

Takeda

Phase 2

268

Bologna, Milan, Palermo, Roma, Rome, Rozzano

2024-03-05

Active, closed

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

NCT06292013Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)

DrugLepodisiran

Eli Lilly and Company

Phase 3

17,300

Arzignano, Baggiovara, Bologna, Cinisello Balsamo, Ferrara, Florence, Genova, Milan

2024-03-05

Recruiting

An Italian Multicentric Retrospective Observational Study to Assess Effectiveness and Safety of the Combination of Tafasitamab and Lenalidomide in Diffuse Large B-cell Lymphoma Patients Treated Under Named Patient Program

NCT06782789Diffuse Large B Cell Lymphoma (DLBCL)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna, Caserta, Catania, Ferrara, Florence, Milan, Novara, Palermo

2024-03-01

Recruiting

Comparison of Hemodialysis Techniques in the Removal of Uremic Toxins in Chronic Renal Failure

NCT06794216Dialysis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2024-03-01

Recruiting

Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma

NCT06261658Cryopreservation, Ovary Injury, Infertility, Female, Menopause Ovarian Failure

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2024-03-01

Recruiting

A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

NCT06161025Solid Cancer

DrugsR-DXd·Topotecan·Paclitaxel

Daiichi Sankyo

Phase 2/3

860

Aviano, Bologna, Catania, Florence, Milan, Monza, Naples, Roma

2024-02-27

Recruiting

De Quervain's Disease in the Acute Phase:a Study Aimed at Evaluating the Effectiveness of Standard Physiotherapy Treatment (HANDGUIDE), Compared to Experimental Treatment After Performing Ultrasound-guided Infiltrative Therapy.

NCT06296472De Quervain Disease, Hand Tenosynovitis

Istituto Ortopedico Rizzoli

Not applicable

134

Bologna

2024-02-27

Active, closed

Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)

NCT05925530Non-small Cell Lung Cancer

DrugDurvalumab

AstraZeneca

Phase 2

142

Bari, Bologna, Milan, Naples, Palermo, Pavia, Peschiera del Garda

2024-02-22

Recruiting

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

NCT06001788AML, AML With Mutated NPM1, Hematologic Malignancy, KMT2Ar

DrugsXospata·Granulocyte Colony-Stimulating Factor·Ziftomenib·Idarubicin

Kura Oncology, Inc.

Phase 1

171

Bologna, Ravenna, Roma

2024-02-22

Recruiting

Arterial Chemoembolization for the Treatment of Desmoid Fibromatosis

NCT06268457Desmoid

Istituto Ortopedico Rizzoli

Observational

Bologna

2024-02-20

Recruiting

Radiomics Compared With Conventional Response Criteria for Predicting Progression of Desmoid Tumor After Cryoablation

NCT06224283Desmoid

Istituto Ortopedico Rizzoli

Observational

Bologna

2024-02-20

Active, closed

ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function

NCT05907096Delayed Graft Function

DrugEmpasiprubart

argenx

Phase 2

103

Bologna, Padova, Torino

2024-02-17

Recruiting

Role of Spectral CT in the Evaluation of Cardiotoxicity in Patients With Hodgkin's Lymphoma and Diffuse Large B-cell Lymphoma Treated With Anthracyclines

NCT06774326Cardiac Imaging, Cardiac Imaging Techniques, Lymphoma, Hodgkin Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

160

Bologna

2024-02-14

Recruiting

CAS vs Standard Technique in TKA: Comparison of Clinical and Functional Results

NCT06608745Knee Arthroplasty, Total

Istituto Ortopedico Rizzoli

Not applicable

160

Bologna

2024-02-12

Recruiting

Study on Post-acute Myocardial Infarction Ventricular Defect: Outcome Evalutation in Relation to Surgical Timing

NCT06799780Myocardial Infarction (MI), Heart Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna, Udine, Varese

2024-02-12

Recruiting

Effectiveness of Telerehabilitation in Continuity With Outpatient Physiotherapy After Total Hip Replacement.

NCT06238960Total Hip Replacement, Telerehabilitation, Physiotherapy

Istituto Ortopedico Rizzoli

Not applicable

104

Bologna

2024-02-10

Recruiting

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

NCT06152575Multiple Myeloma

DrugsElotuzumab·Elranatamab·Carfilzomib·Pomalidomide

Pfizer

Phase 3

492

Milan, Legnano, Turin, Palermo, Ancona, Florence, Pisa, Bologna

2024-02-08

Recruiting

Open-label Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy

NCT06484868Partial Lipodystrophy

DrugMetreleptin

Amryt Pharma

Phase 4

Bologna, Catanzaro, Novara, Pisa, Udine

2024-02-08

Active, closed

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

NCT06191744Follicular Lymphoma (FL)

DrugsEpcoritamab·Bendamustine·Obinutuzumab·Vincristine

Genmab

Phase 3

1,095

Rozzano, Candiolo, Bologna, Catania, Palermo, Reggio Emilia, Roma

2024-02-05

Recruiting

Study of Olverembatinib (HQP1351) in Patients With CML-CP

NCT06423911Chronic Myeloid Leukemia, CML, CML, Chronic Phase

DrugsBosutinib·Olverembatinib

Ascentage Pharma Group Inc.

Phase 3

333

Bologna, Candiolo, Catania, Lecce, Meldola, Messina, Milan, Naples

2024-02-05

Recruiting

Treatment and Outcome of Patients With Mild Head Injury

NCT07339319Head Injury Trauma

Azienda USL Reggio Emilia - IRCCS

Observational

4,500

Bologna, Modena, Reggio Emilia

2024-02-01

Recruiting

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

NCT05902169Glioblastoma, Recurrent Glioblastoma, GBM

DrugsLomustine·Temodal·Temozolomide·Carboplatin

CarThera

Phase 3

560

Bologna, Livorno, Padua, Roma, Rozzano, Torino

2024-01-29

Recruiting

Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma

NCT06243588Ewing Sarcoma

Istituto Ortopedico Rizzoli

Observational

400

Bologna

2024-01-25

Recruiting

AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.

NCT06137144Lymphoma, Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Peripheral T-cell Lymphoma (PTCL)

DrugsAZD3470·Keytruda·Pembrolizumab

AstraZeneca

Phase 1/2

161

Alessandria, Bologna, Milan

2024-01-23

Active, closed

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

NCT06143891Chronic Graft Versus Host Disease

DrugsBelumosudil·Prednisolone·Prednisone

Sanofi

Phase 3

260

Torette, Genoa, Milan, Rozzano, Rome, Turin, Bergamo, Bologna

2024-01-23

Active, closed

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

NCT06208150Multiple Myeloma

DrugsElotuzumab·Talquetamab·Velcade·Teclistamab

Janssen Research & Development, LLC

Phase 3

838

Alessandria, Bologna, Brindisi, Catania, Genova, Legnano, Milan, Pavia

2024-01-22

Recruiting

Quality of Life and Decisional Regret in Patients Affected by Acoustic Neuroma

NCT06844461Quality of Life Outcomes, Acoustic Schwannoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2024-01-20

Active, closed

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis

NCT06260163Colitis, Ulcerative

DrugsTremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

112

Bergamo, Bologna, Florence, Pescara, Roma, San Giovanni Rotondo, Trieste

2024-01-19

Recruiting

Genotype-phenotype Relationship Between Cryptogenic Cholestasis and Familial Intrahepatic Cholestasis

NCT06781242Cholestatic Liver Disease, Intrahepatic Cholestasis, Progressive Familial Intrahepatic Cholestasis, Hepatobiliary Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

300

Bologna, Modena

2024-01-16

Active, closed

Study of ALXN2220 Versus Placebo in Adults With ATTR-CM

NCT06183931Transthyretin Amyloid Cardiomyopathy

DrugCliramitug

Alexion Pharmaceuticals, Inc.

Phase 3

1,181

Bologna, Ferrara, Florence, Forlì, Messina, Milan, Naples, Padova

2024-01-11

Recruiting

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

NCT06064877Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

DrugsErbitux·Cetuximab

AVEO Pharmaceuticals, Inc.

Phase 3

410

Bologna, Florence, Milan, Novara, Padua, Pavia, Roma

2024-01-11

Active, closed

A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

NCT06109272Hepatocellular Carcinoma

DrugsLivmoniplimab·Budigalimab·Tremelimumab·Atezolizumab

AbbVie

Phase 2/3

Rozzano, Milan, Naples, Rome, Bologna, Palermo, Roma

2024-01-11

Recruiting

Risk and Protective Factors for Relapse to Alcohol Use in Patients With Liver Disease Undergoing Liver Transplantation

NCT06749990Alcohol Related Liver Disease, Orthotopic Liver Transplantation

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

320

Bologna

2024-01-09

Recruiting

Monitoring of Patients With Inflammatory Bowel Diseases: the Experience of the Reference Center of the Emilia-Romagna

NCT06721767IBD - Inflammatory Bowel Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

10,000

Bologna

2024-01-08

Recruiting

Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis

NCT06040957Knee Osteoarthritis

DrugBone marrow aspirate

Istituto Ortopedico Rizzoli

Not applicable

204

Bologna

2024-01-08

Recruiting

Safety and Efficacy of RVU120 Combined With Venetoclax for Treatment of Relapsed/Refractory AML

NCT06191263Acute Myeloid Leukemia

DrugsRVU120·Venetoclax

Ryvu Therapeutics SA

Phase 2

Meldola, Ancona, Bologna, Brescia, Lecce, Ravenna, Roma, Rozzano

2024-01-05

Active, closed

Pasireotide s.c. in Patients With Post-Bariatric Hypoglycaemia

NCT05928390Post-Bariatric Hypoglycemia

RECORDATI GROUP

Phase 2

Bologna, Padova, Palermo, Rome

2024-01-04

Recruiting

Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population

NCT06870006Eating Disorders, Mood Disorders in Children and Adolescents, Psychotic Disorder, QTc Intervals Changes

Meyer Children's Hospital IRCCS

Observational

100

Troina, Florence, Calambrone, Bologna, Cagliari, Messina

2024-01-01

Recruiting

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

NCT05950945Breast Cancer

DrugTrastuzumab deruxtecan

Daiichi Sankyo

Phase 3

250

Bari, Bologna, Genova, Milan, Misterbianco, Naples, Padova, Prato

2023-12-30

Recruiting

AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia

NCT06137118B-cell Acute Lymphoblastic Leukemia (B-ALL)

DrugSurovatamig

AstraZeneca

Phase 1/2

255

Bergamo, Bologna, Monza, Naples, Roma

2023-12-29

Recruiting

A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas

NCT06090539Relapsed/Refractory Non-Hodgkin Lymphoma

DrugsGolcadomide·Mosunetuzumab·Epcoritamab·Truxima

Bristol-Myers Squibb

Phase 1/2

460

Bologna, Brescia, Milan, Pisa, Ravenna, Roma, Verona

2023-12-29

Recruiting

A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone Lymphoma

NCT06149286Relapsed/Refractory Follicular Lymphoma, Relapsed/Refractory Marginal Zone Lymphoma (R/R MZL)

DrugsOdronextamab·Lenalidomide·Rituximab

Regeneron Pharmaceuticals

Phase 3

580

Meldola, Genoa, Monza, Turin, Aviano, Candiolo, Bologna, Brescia

2023-12-28

Recruiting

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

NCT06059638Hypertension, Hypertension, Systolic, Hypertension, Essential

Orchestra BioMed, Inc

Not applicable

316

Bologna, Rome, Verona

2023-12-27

Recruiting

Efficacy of Isatuximab-based Regimens in Relapsed/Refractory Multiple Myeloma With 1q21+

NCT06874530Multiple Mieloma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-12-27

Recruiting

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

NCT06119581Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

DrugsOlomorasib·Pemetrexed·Cisplatin·Carboplatin

Eli Lilly and Company

Phase 3

1,264

Bari, Bologna, Catania, Milan, Naples, Padova, Roma, Rome

2023-12-21

Active, closed

Proof of Concept Study on Pitolisant Effect on Autism Spectrum Disorders in Children and Adolescents

NCT05953389Autism Spectrum Disorder

DrugPitolisant

Bioprojet

Phase 2

Bologna, Bosisio Parini, Cagliari, Calambrone, Foggia, Messina, Naples, Pavia

2023-12-20

Recruiting

A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

NCT06150157Neoplasms

DrugsMomelotinib·Ruxolitinib

Janssen Research & Development, LLC

Phase 1

300

Bologna, Milan

2023-12-20

Recruiting

Acellular Matrix From Human Dermis in Combination With Orthobiologic Stimuli for Augmentation of Massive Rotator Cuff Tears

NCT05855759Rotator Cuff Tears

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-12-18

Recruiting

A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials

NCT06285318Relapsed/Refractory Multiple Myeloma (RRMM)

Janssen-Cilag Ltd.

Observational

900

Bologna, Bolzano, Brindisi, Florence, Lecce, Milan, Naples, Palermo

2023-12-18

Active, closed

Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome

NCT06813469Ring 14

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2023-12-15

Active, closed

A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib

NCT05734105GIST

DrugsRipretinib·Sunitinib

Deciphera Pharmaceuticals, LLC

Phase 3

Naples, Palermo, Bologna, Milan, Padova, Roma, Rozzano

2023-12-13

Recruiting

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

NCT06128629Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

DrugNexiguran ziclumeran

Intellia Therapeutics

Phase 3

1,200

Bologna, Cona, Florence, Genova, Pavia, Pisa, Trieste

2023-12-13

Recruiting

Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)

NCT06263075Craniosynostoses, Hypovolemia, Hemorrhage, Hemodynamic Instability

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-12-13

Recruiting

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

NCT06091254Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Bendamustine

Regeneron Pharmaceuticals

Phase 3

822

Meldola, Tricase, Genoa, Candiolo, Ascoli Piceno, Bologna, Brescia, Milan

2023-12-12

Recruiting

Non-invasive Detection of Acute Cell-mediated Graft Rejection in Pediatric Heart Transplant Recipients

NCT06795958Pediatric Heart Transplant

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-12-12

Active, closed

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

NCT06065748Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

DrugsGiredestrant·Abemaciclib·Ribociclib·Palbociclib

Hoffmann-La Roche

Phase 3

1,050

Brindisi, Avellino, Naples, Bologna, Meldola, Parma, Aviano (PN), Udine

2023-12-11

Active, closed

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

NCT06132958Endometrial Cancer

DrugsAbraxane·Adriamycin·Sacituzumab tirumotecan·Taxol

Merck Sharp & Dohme LLC

Phase 3

710

Bologna, Aviano, Rome, Milan, Rozzano, Candiolo, Bari, Brescia

2023-12-06

Active, closed

A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)

NCT06127043Ulcerative Colitis

DrugRosnilimab

AnaptysBio, Inc.

Phase 2

132

Bologna, Cagliari, Catania, Legnano, Milan, Pavia, Rozzano, San Donato

2023-12-04

Active, closed

A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patients

NCT06514807Essential Thrombocythaemia

DrugBesremi

AOP Orphan Pharmaceuticals AG

Phase 3

117

Bologna, Florence, Rome, Turin

2023-12-04

Recruiting

The Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) Study

NCT05847387Corneal Transplant Failure, Corneal Endothelial Cell Loss

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Observational

135

Brescia, Bologna, Catanzaro, Roma, Venice, Vicenza

2023-12-01

Recruiting

The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)

NCT06408441Epithelioid Hemangioendothelioma, Sarcoma,Soft Tissue

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

100

Bologna, Careggi, Rozzano, Milan, Padova, Palermo, Prato, Roma

2023-12-01

Recruiting

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NCT06215716NASH With Fibrosis, MASH With Fibrosis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

1,650

San Giovanni Rotondo, Rozzano, Torino, Bologna, Foggia, Messina, Milan, Modena

2023-12-01

Recruiting

PK/PD Relationship of CAZ/AVI and FOS in the Treatment of Patients With Infections Due to CRE

NCT06717594Gram Negative Infections, Antimicrobial Resistance (AMR)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-12-01

Active, closed

Pediatric Oncological Orthopaedic Reconstruction

NCT06522165Bone Tumor, Bone Cancer

Costantino Errani

Observational

400

Bologna

2023-12-01

Recruiting

A Study to Observe How Pediatric Patients With Severe Atopic Dermatitis Despite Less Extensive Skin Lesions Respond to Dupilumab Treatment

NCT06192563Atopic Dermatitis

DrugDupilumab

Sanofi

Observational

230

Bologna, Brescia, Florence, Milan, Naples, Roma, Verona

2023-11-30

Recruiting

Biologic Characterization of Patients With ITP

NCT05694325Immune Thrombocytopenia

Gruppo Italiano Malattie EMatologiche dell'Adulto

Not applicable

200

Bologna, Piacenza, Roma, Torino, Trieste

2023-11-27

Recruiting

Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

NCT05948943Lymphatic Malformations

DrugAlpelisib

Novartis Pharmaceuticals

Phase 2/3

232

Bologna, Milan, Roma, Torino, Naples

2023-11-24

Recruiting

Use of Three-dimensional Transvaginal Ultrasound for Anal Sphincter Evaluation

NCT06773520Obstetric Anal Sphincter Injury

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

200

Bologna

2023-11-21

Active, closed

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

NCT06016738Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Exemestane·Anastrozole·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

510

Avellino, Bologna, Meldola, Modena, Reggio Emilia, Udine, Rome, Milan

2023-11-16

Recruiting

Maternal-fetal Outcomes of Genital Blood Loss Beyond 18 Weeks of Pregnancy

NCT06802874Blood Loss

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

300

Bologna

2023-11-15

Recruiting

CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine

NCT06158698Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure

DrugColchicine

Niguarda Hospital

Phase 3

Naples, Bologna, Trieste, Udine, Rome, Milan, Turin, Ancona

2023-11-14

Active, closed

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

NCT06062420Neoplasms, Head and Neck

DrugsRemzistotug·Nelistotug·Belrestotug·Dostarlimab

GlaxoSmithKline

Phase 2

316

Rozzano, Bari, Bologna, Florence, Genova, Milan, Naples, Novara

2023-11-14

Active, closed

Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease

NCT06075706Steroid-refractory Acute Graft-versus-host Disease

DrugMC0518

medac GmbH

Phase 2

Bologna, Monza, Pavia, Rome, Turin

2023-11-13

Recruiting

Study of the Immunological Infiltrate and Immunometabolic Immunometabolic Profile of Patients with Acute Leukaemia

NCT06814444Acute Leukemia

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

170

Bologna

2023-11-11

Active, closed

Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)

NCT06073821CLL

DrugsSonrotoclax·Zanubrutinib·Obinutuzumab·Venetoclax

BeOne Medicines

Phase 3

652

Bologna, Ferrara, Milan, Novara, Padova, Perugia

2023-11-11

Recruiting

Study of the Anatomical and Functional Recovery and Quality of Life of Patients Undergoing Corneal Transplantation

NCT06830538Cornea Transplant

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

2,000

Bologna

2023-11-11

Recruiting

CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative Chemotherapy Versus Immediate Resection in patIents With resecTable BiliarY Tract Cancers (BTC) at High Risk for Recurrence

NCT06037980Biliary Tract Cancer, Cholangiocarcinoma

DrugsAbraxane·Nab-paclitaxel·Capecitabine·Gemcitabine

Gruppo Oncologico del Nord-Ovest

Phase 2/3

300

Ancona, Bergamo, Bologna, Brescia, Cuneo, Meldola, Milan, Modena

2023-11-07

Recruiting

Clinical Validation of BBCT-hip

NCT06270758Osteoporosis

Istituto Ortopedico Rizzoli

Observational

300

Bologna

2023-11-07

Active, closed

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

NCT06087835Chronic Kidney Disease With High Proteinuria

DrugDapagliflozin

AstraZeneca

Phase 3

1,835

Bergamo, Bologna, Foggia, Genoa, Naples, Pisa, Roma, Torino

2023-11-07

Active, closed

Bail-Out Stenting and Target-vessel Failure After Drug Coated Balloon Coronary percutaneouS Angioplasty for de Novo Lesions

NCT06247982DCB, De Novo Stenosis, PCI

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

800

Bologna

2023-11-06

Active, closed

Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.

NCT05782907Ulcerative Colitis

DrugUpadacitinib

AbbVie

Phase 3

122

Florence, Rome, Bologna

2023-11-06

Recruiting

European Study of Prodromal iNPH

NCT05910944Normal Pressure Hydrocephalus, Hydrocephalus

Johan Virhammar

Observational

140

Bologna

2023-11-01

Recruiting

Early MOtion Total Ankle Artroplasty

NCT06525545Ankle Osteoarthritis, Ankle - Recurrent Dislocation, Cartilage Disease, Ankle Arthropathy

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-10-31

Recruiting

Treatment of Low-flow Venous Malformations With Electrosclerotherapy. Prospective Observational Study

NCT06189092Vascular Malformations

DrugBleomycin

Istituto Ortopedico Rizzoli

Observational

Bologna

2023-10-28

Recruiting

Whole Body MRI in Oncology

NCT06895291Lymphoma, Advanced Prostate Cancer, Advanced Breast Cancer, Monoclonal Gammopathy of Undetermined Significance

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Observational

1,000

Bologna, Meldola, Milan

2023-10-26

Active, closed

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

NCT05949684Myelodysplastic Syndromes

DrugsEpoetin Alfa·Reblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

402

Rome, Milan, Rozzano, Turin, Florence, Bologna, Reggio Calabria, Roma

2023-10-24

Active, closed

A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

NCT05952037Waldenstrom Macroglobulinemia, Waldenstrom's Macroglobulinemia Recurrent, Waldenstrom's Macroglobulinemia Refractory

DrugsSonrotoclax·Zanubrutinib

BeOne Medicines

Phase 2

114

Bologna, Brescia, Milan, Pavia, Roma, Udine

2023-10-23

Recruiting

A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma

NCT06084936Lymphoma

DrugsGlofitamab·Bendamustine·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 3

182

Bologna, Bergamo, Milan, Alessandria, Turin

2023-10-22

Recruiting

Electronic Archive of Internal Medicine for the Treatment of Severe Organ Failure and Liver Transplantation-MITIGO

NCT06781502Organ Failure, Multiple, LIVER TRANSPLANTATION

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

10,000

Bologna

2023-10-21

Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

NCT06026410Solid Tumors With HRAS Alterations, Non Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)

DrugsAdagrasib·Cabozantinib

Kura Oncology, Inc.

Phase 1

300

Bologna, Candiolo, Naples, Rozzano, Verona

2023-10-18

Active, closed

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation

NCT06045806Multiple Myeloma

DrugsIdecabtagene vicleucel·Endoxan·Fludara·Cytoxan

Celgene

Phase 3

Rozzano, Bologna, Roma

2023-10-16

Active, closed

A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

NCT06075667Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

160

Bologna, Verona, Messina, Novara

2023-10-16

Recruiting

Acute Hepatitis in Pediatrics

NCT06761261Hepatitis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

437

Bologna

2023-10-16

Active, closed

A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults

NCT06047444Chronic Migraine

DrugsDysport·Botulinum toxin type A

Ipsen

Phase 3

759

Bologna, Naples, Pavia, Pozzilli, Roma

2023-10-12

Recruiting

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

NCT06012240Alopecia Areata

DrugUpadacitinib

AbbVie

Phase 3

1,500

Florence, L’Aquila, Rozzano, Naples, Rome, Bologna, Brescia, Catania

2023-10-11

Recruiting

Homologus PRP in the Infiltrative Treatment of Knee Osteoarthritis in Young Athletic Patients

NCT06483269Knee Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-10-10

Recruiting

DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease

NCT06316232Freezing of Gait, Parkinson Disease

IRCCS Istituto delle Scienze Neurologiche di Bologna

Phase 4

Bologna

2023-10-10

Active, closed

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

NCT05952557Breast Cancer, Early Breast Cancer

DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole

AstraZeneca

Phase 3

5,511

Bergamo, Bologna, Florence, Genoa, Meldola, Milan, Misterbianco, Monza

2023-10-05

Active, closed

A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

NCT05936359Myeloproliferative Neoplasms

DrugsINCA033989·Ruxolitinib

Incyte Corporation

Phase 1

160

Bologna, Florence, Milan

2023-09-25

Recruiting

Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)

NCT06079671Locally Advanced Cervical Cancer

DrugVolrustomig

AstraZeneca

Phase 3

800

Bari, Bologna, Catania, Florence, Lecco, Milan, Monza, Naples

2023-09-22

Active, closed

Mid- and Long-term Evaluation of the Results of Patients Undergoing Spinal Cord Stimulation With Microfractures + BST CarGel in the Treatment of Patellofemoral Chondral Lesions of the Knee

NCT06477315Chondral Lesion of the Knee, Patellofemoral Disorder

Istituto Ortopedico Rizzoli

Observational

Bologna

2023-09-22

Active, closed

Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)

NCT06088290Leiomyosarcoma

DrugsLurbinectedin·Doxorubicin

PharmaMar

Phase 3

469

Rozzano, Naples, Aviano, Bologna, Candiolo, Orbassano, Padova, Palermo

2023-09-21

Active, closed

Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)

NCT05822752Hepatocellular Carcinoma

DrugsLivmoniplimab·Budigalimab·Sorafenib·Lenvatinib

AbbVie

Phase 2

130

Florence, Milan, Naples, Bologna, Palermo, Roma

2023-09-21

Recruiting

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05730036Relapsed Refractory Multiple Myeloma (RRMM)

DrugsElotuzumab·Linvoseltamab·Pomalidomide·Dexamethasone

Regeneron Pharmaceuticals

Phase 3

410

San Giovanni Rotondo, Meldola, Genoa, Alessandria, Turin, Candiolo, Ancona, Bologna

2023-09-18

Active, closed

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

NCT06047080Large B-Cell Lymphoma

DrugsPolatuzumab Vedotin·Glofitamab·Doxorubicin·Prednisone

Hoffmann-La Roche

Phase 3

1,130

Naples, Bologna, Modena, Genoa, Bergamo, Milan, Rozzano, Catania

2023-09-18

Recruiting

Immunodysregulation As an Expression of Underlying Inborn Errors of Immunity: Implementation of Diagnostics and Management of Pediatric and Adult Patients with Immune System Disorders

NCT06773546Inborn Errors of Immunity

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

400

Bologna

2023-09-15

Active, closed

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis

NCT06003426Idiopathic Pulmonary Fibrosis

DrugAdmilparant

Bristol-Myers Squibb

Phase 3

1,255

Bologna, Modena, Florence, Milan, Pisa, Roma, Ancona, Bergamo

2023-09-14

Active, closed

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

NCT05904886Hepatocellular Carcinoma

DrugsTiragolumab·Tecentriq·Avastin·Atezolizumab

Hoffmann-La Roche

Phase 3

687

Tricase, Bologna, Rome, Genoa, Rozzano, Palermo, Verona

2023-09-14

Recruiting

Copeptin and Thirst: Possible Predictive Markers of Effectiveness of Bariatric Surgery?

NCT06806787Obesity

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-09-13

Recruiting

The Effect of Cord Blood Serum Eyes Drops Administer in Patients With Severe Keratopathy Related to EGFR-I Treatment

NCT06830551Dry Eye

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2023-09-12

Recruiting

Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients With Relapsed or Refractory Marginal Zone Lymphoma

NCT06006117Marginal Zone Lymphoma

DrugsMosunetuzumab·Bendamustine·Lenalidomide·Rituximab

The Lymphoma Academic Research Organisation

Phase 3

260

Bologna, Castelfranco Veneto, Cuneo, Latina, Lecce, Milan, Modena, Pavia

2023-09-05

Recruiting

The ReTAVI Prospective Observational Registry

NCT05601453Structural Valve Deterioration, Structural Valve Degeneration, Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction

Institut für Pharmakologie und Präventive Medizin

Observational

250

Ancona, Bologna, Brescia, Florence, Milan, Padua, Pisa, Roma

2023-09-05

Recruiting

Precision Medicine in the Management of Heart Transplant Recipients

NCT06774794Heart Transplantation

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

200

Bologna

2023-09-04

Recruiting

Electronic Register on Advanced Heart Failure and Transplantation di Cuore

NCT06773611Heart Failure, Heart Transplantation

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

10,000

Bologna

2023-09-04

Recruiting

Observational Epidemiological Study of Patients Suffering From Systemic Amyloidosis

NCT06866912Cardiomyopathy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

750

Bologna

2023-09-01

Active, closed

Enlighten Study: The EV-ICD Post Approval Registry

NCT06048731Ventricular Arrhythmia, Tachycardia

Medtronic

Observational

1,000

Bari, Bologna, Milan, Monza

2023-09-01

Recruiting

Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy

NCT05999851Preeclampsia, Hypertensive Disorder of Pregnancy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

400

Bologna

2023-09-01

Recruiting

A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1)

NCT06051409Ph+ ALL, Leukemia, Lymphoblastic, Acute, Philadelphia-Positive

DrugOlverembatinib

Ascentage Pharma Group Inc.

Phase 3

350

Bologna, Meldola, Milan, Monza, Ravenna, Roma, Torino, Varese

2023-08-31

Recruiting

Knee Osteotomy Associated With Allograft Meniscus Transplantation

NCT05840887Malalignment, Bone, Osteoarthritis, Knee

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-08-30

Recruiting

Assessment of Periprosthetic Bone Mineral Density in Patients Undergoing Total Knee Prosthesis of Different Design

NCT06309433Periprosthetic Osteolysis

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-08-30

Active, closed

An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD)

NCT06254482Huntington Disease

DrugVotoplam

Novartis Pharmaceuticals

Phase 2

144

Bologna, Milan, San Giovanni Rotondo

2023-08-25

Active, closed

Diarrheal Adverse Events in Caucasian Patients With Idiopathic Pulmonary Fibrosis Undergoing Treatment With Nintedanib

NCT06714812IPF

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2023-08-20

Active, closed

A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

NCT05797610Primary IgA Nephropathy

Hoffmann-La Roche

Phase 3

459

Bari, Naples, Bologna, Rome, Genoa, Pavia, Turin

2023-08-08

Recruiting

Reconstructions of Chest Wall Defects: a Retrospective Study

NCT06774755Chest Wall Deformity

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2023-08-02

Recruiting

Comparison of Customized and Standard Total Ankle Prostheses

NCT06193057Ankle Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-07-26

Recruiting

Comparison of Echo-assisted ALR Technique and Traditional ALR Technique for the Placement of an Epidural Catheter in the Obstetric Patient

NCT06811649Pregnancy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

146

Bologna

2023-07-17

Recruiting

Diagnosis and Outcomes of Placental Accretism

NCT06833606Placenta Accreta

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna, Cesena, Forlì, Modena, Parma, Reggio Emilia, Rimini

2023-07-17

Recruiting

Minimally Invasive Surgery vs Standard Posterior Approach in the Treatment of Developmental Idiopathic Scoliosis

NCT05860673Adolescent Idiopathic Scoliosis

Istituto Ortopedico Rizzoli

Not applicable

126

Bologna

2023-07-15

Recruiting

The Role of the Vascular Surgeon in Oncologic Surgery of Abdominal and Pelvic Retroperitoneal Masses

NCT06803251Retroperitoneal Neoplasms

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-07-14

Active, closed

Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension

NCT05968430Hypertension

Mineralys Therapeutics Inc.

Phase 3

1,076

Bologna, Ferrara, Genova, Messina, Pisa, Roma

2023-07-14

Recruiting

Identification and Treatment of Renal Stenosis in Transplanted Kidneys

NCT06822205Renal Artery Stenosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-07-07

Active, closed

Zenith Thoracic Alpha (ZTA) Post-Market Data Collection

NCT06094127Thoracic Aortic Aneurysm, Penetrating Aortic Ulcer

Cook Research Incorporated

Observational

300

Bologna, Milan

2023-07-06

Recruiting

Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement

NCT05727176Advanced Cholangiocarcinoma, FGFR2 Fusions, Gene Rearrangement

DrugFutibatinib

Taiho Oncology, Inc.

Phase 2

120

Bologna, Rozzano, Verona

2023-07-05

Active, closed

Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy

NCT05696717Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy

Theravance Biopharma

Phase 3

102

Bologna, Milan, Rome, Salerno, Terni, Trento, Tricase

2023-06-27

Recruiting

Use of Shockwave M5+/L6 IVL Catheter (Intravascular Lithotripsy) in Hostile and Calcified Iliac Access

NCT05880641Aortic Diseases, Aorto-Iliac Atherosclerosis, Peripheral Arterial Disease

EndoCore Lab s.r.l.

Observational

Ancona, Bologna, Rome, Florence, Perugia, Padova

2023-06-26

Active, closed

A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT05776472Paroxysmal Nocturnal Hemoglobinuria

DrugPegcetacoplan

Swedish Orphan Biovitrum

Observational

165

Bari, Bassano del Grappa, Bologna, Cagliari, Florence, Milan, Novara, Reggio Calabria

2023-06-26

Recruiting

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358Acute Myocardial Infarction, Coronary Artery Disease

Population Health Research Institute

Not applicable

5,100

Arezzo, Bologna, Ferrara, Grosseto, Reggio Emilia, Rome

2023-06-22

Recruiting

Perineal and Abdominal Reconstruction: a Comparison of Reconstructive Methodologies

NCT06800534Surgery

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-06-21

Recruiting

Latissimus Dorsi Flap Reconstructions: Retrospective Study

NCT06800547Surgery

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

200

Bologna

2023-06-21

Recruiting

The Role of the Vascular Surgeon in Orthopedic Surgery of Musculoskeletal Tumors

NCT06818552Muscle Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-06-21

Recruiting

Surgical Treatments for Postamputation Pain

NCT05009394Residual Limb Pain, Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic

Prometei Pain Rehabilitation Center

Not applicable

110

Bologna

2023-06-20

Recruiting

Ganciclovir Resistant/Refractory Cytomegalovirus Infection in SOT Recipients and HSCT Patients

NCT05234723Cytomegalovirus Infections

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna, Rozzano, Palermo, Genova, Milan, Modena, Naples, Padova

2023-06-19

Recruiting

Study of Loncastuximab Tesirine in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) or High-Grade B-Cell Lymphoma (HGBCL) Following CAR-T Therapy Failure

NCT06918912Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma (HGBCL), B-Cell Lymphoma Treatment, Relapsed or Refractory Lymphoma

DrugLoncastuximab Tesirine

Istituto Clinico Humanitas

Phase 2

Alessandria, Bologna, Cuneo, Milan, Rozzano, Roma

2023-06-16

Active, closed

An Observational Study to Assess Change in Disease Activity and Adverse Events In Adult Participants With Moderate to Severe Active Crohn's Disease (CD)

NCT05841537Crohn's Disease

AbbVie

Observational

1,019

Florence, Rozzano, Milan, Rome, Bari, Bologna, Messina

2023-06-09

Active, closed

Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies

NCT05753501Hematologic Cancer

DrugVenetoclax

AbbVie

Phase 1

135

Milan, Turin, Bergamo, Bologna

2023-06-09

Active, closed

Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism

NCT05778071Chronic Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases

Alexion Pharmaceuticals, Inc.

Phase 3

165

Bologna, Florence, Milan, Pisa, Roma

2023-06-07

Recruiting

European Aortic Data Collection Project

NCT05896397Complex Abdominal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Aortic Arch Aneurysm, Chronic Aortic Dissection

Cook Research Incorporated

Observational

600

Bologna, Genova, Milan

2023-05-31

Recruiting

Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck

NCT05484115Aortic Aneurysm, Abdominal

Rijnstate Hospital

Not applicable

300

Genova, Bologna

2023-05-26

Recruiting

Detection of Circulating Tumour Cells, Spread Through Air Space in Patients With Lung Cancer

NCT06833632Non-Small-Cell Lung Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2023-05-25

Recruiting

Preoperative Boost Associated With Neoadjuvant Chemotherapy in Luminal B Breast Cancer

NCT05673304Breast Cancer, Radiotherapy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2023-05-24

Active, closed

Assessment of Circulating Tumor Cells and microRNAs in Patients With Metastatic Non-cutaneous Melanoma

NCT06863870Melanoma Neoplasms

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-05-24

Recruiting

Precision Diagnosis and Therapy for Rare Diseases by Interpreting Non-coding Genomes

NCT06775561Neuromuscular Diseases, Eye Diseases, Genetic Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2023-05-20

Active, closed

Vertebral Bone Marrow Clot for Spinal Surgery

NCT05947175Degenerative Spine Diseases

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-05-19

Recruiting

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

NCT05442567Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

240

Naples, Bologna, Rome, Monza, Florence, Padova

2023-05-16

Recruiting

Safety and Feasibility of a Multidisciplinary Programme of Integrated Hospital-home Management With Early Discharge of Patients With Haematological Malignancies Undergoing High-dose Chemotherapy in Hospital

NCT06814405Haematological Malignancy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

100

Bologna

2023-05-11

Recruiting

Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment

NCT06321588Cognitive Impairment, Dementia

Azienda Usl di Bologna

Observational

300

Bologna, Milan

2023-05-10

Recruiting

Arterial Embolization for the Treatment of Bone Metastases: Prospective Observational Study

NCT06189079Bone Metastases

Istituto Ortopedico Rizzoli

Observational

Bologna

2023-05-10

Active, closed

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

NCT05840211Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast Cancer

DrugsAbraxane·Xeloda·Sacituzumab Govitecan·Taxol

Gilead Sciences

Phase 3

654

Ancona AN, Aviano, Bergamo, Bologna, Catania, Catanzaro, Genova GE, Milan

2023-05-08

Active, closed

Functional Coronary Angiography Guided Revascularization in STEMI

NCT05818475Myocardial Infarction

University Hospital of Ferrara

Not applicable

1,823

Bologna, Ferrara, Bolzano, Catanzaro, Cosenza, Baggiovara, Piacenza, Parma

2023-05-08

Active, closed

An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma

NCT05876754Cholangiocarcinoma

DrugIvosidenib

Servier Affaires Médicales

Phase 3

299

Bologna, Florence, Milan, Naples, Reggio Emilia, Roma, Rozzano, San Giovanni Rotondo

2023-05-03

Recruiting

Tissue Study on the Chronic Active Humoral Rejection (cAMR) Population of Kidney Transplantation

NCT06794970Kidney Transplant

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-05-01

Active, closed

TRanscatheter Aortic-Valve Implantation With or Without On-site Cardiac Surgery: the TRACS Trial

NCT05751577Aortic Stenosis, Severe

Azienda Usl di Bologna

Not applicable

657

Bologna, Arezzo, Asti, Biella, Ferrara, Forlì, Grosseto, Mirano

2023-05-01

Recruiting

Fecal Microbiota Transplantation for the Prevention of Infectious Complications After Liver Transplantation

NCT06782880Fecal Microbiota Transplantation, Orthotopic Liver Transplantation, Multi-drug Resistant Bacteria

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

144

Bologna

2023-05-01

Recruiting

Diagnostic Value of Next-Generation Sequencing Analysis in Biliary Tract Tumours

NCT06729944Hepatectomy, NGS, Stenosis of Bile Duct

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2023-04-27

Active, closed

Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)

NCT05804045Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath

DrugPimicotinib

Abbisko Therapeutics Co, Ltd

Phase 3

Bologna, Milan, Prato

2023-04-27

By invitation

An Open-label Study of XEN1101 in Epilepsy

NCT05718817Focal Epilepsy, Tonic-Clonic Seizures

DrugAzetukalner

Xenon Pharmaceuticals Inc.

Phase 3

880

Bologna, Chieti, Pisa, Roma

2023-04-25

Active, closed

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

NCT05611931Endometrial Cancer

DrugSelinexor

Karyopharm Therapeutics Inc

Phase 3

257

Bologna, Brescia, Meldola, Milan, Monza, Naples, Padova, Pisa

2023-04-18

Active, closed

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

NCT05645692Urothelial Cancer

DrugsTobemstomig·Tiragolumab·Atezolizumab

Hoffmann-La Roche

Phase 2

204

Bari, Naples, Bologna, Meldola, Rome, Milan, Terni, Padova

2023-04-13

Active, closed

TrEatment Approach in the Multimodal Era Registry

NCT05629052Chronic Thromboembolic Pulmonary Hypertension, CTEPH

International CTEPH Association

Observational

1,000

Bologna

2023-04-12

Active, closed

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

NCT05757869Atrial Fibrillation

DrugsMilvexian·Apixaban

Janssen Research & Development, LLC

Phase 3

20,284

Arezzo, Aversa, Bergamo, Bologna, Caserta, Catania, Catanzaro, Ferrara

2023-04-11

Recruiting

Multicentre Prospective Observational Study of Acute Intoxications in Paediatric Age

NCT06291649Acute Intoxication

Meyer Children's Hospital IRCCS

Observational

Bagno a Ripoli, Borgo San Lorenzo, Forlì, Legnago, Bologna, Bolzano, Cagliari, Empoli

2023-04-05

Active, closed

A Study Evaluating the Effect of Filgotinib in Participants With Active Axial Spondyloarthritis

NCT05785611Axial Spondyloarthritis

DrugFilgotinib

Alfasigma S.p.A.

Phase 3

495

Bologna, Naples, Palermo, Rome, Udine

2023-04-05

Active, closed

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

NCT05794906Biochemically Recurrent Prostate Cancer

DrugDarolutamide

Bayer

Phase 3

985

Foggia, Naples, Bologna, Modena, Reggio Emilia, Aviano, Rome, Genoa

2023-04-03

Active, closed

Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

NCT05819359Parkinson's Disease

Bial R&D Investments, S.A.

Phase 2

237

Bologna, Brescia, Brindisi, Milan, Naples, Padova, Roma, Rozzano

2023-03-31

Active, closed

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05572515Relapsed or Refractory Multiple Myeloma

DrugsTeclistamab·Carfilzomib·Pomalidomide·Bortezomib

Janssen Research & Development, LLC

Phase 3

614

Bologna, Milan, Palermo, Pisa, Reggio Emilia, Roma, Siena, Turin

2023-03-29

Recruiting

Pembrolizumab and Olaparib Treatment of Extensive Small Cell Lung Cancer (ES-SCLC)

NCT05623319SCLC,Extensive Stage

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Phase 2

Meldola, Monza, Pesaro, Bari, Bologna, Naples, Padova, Ravenna

2023-03-27

Active, closed

Role of the Gut Microbiome in the Outcome of Diffuse Large B-Cell Lymphoma Patients Treated With CAR-T Cell Therapy

NCT05725720Diffuse Large B Cell Lymphoma

University of Bologna

Observational

Bologna

2023-03-23

Recruiting

Leukocyte-rich PRP or Leukocyte-free PRP vs Placebo in the Treatment of Epicondylitis

NCT06040203Tennis Elbow

DrugLr-Prp

Istituto Ortopedico Rizzoli

Not applicable

240

Bologna

2023-03-23

Recruiting

Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

NCT05259605Glioma, Glioneuronal Tumor, Choroid Plexus Tumor, Pineal Tumors

European Organisation for Research and Treatment of Cancer - EORTC

Observational

1,650

Bologna, Florence, Milan, Padova, Roma, Torino

2023-03-21

Active, closed

Thoraflex Hybrid and Relay Extension Post-Approval Study

NCT05639400Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm

Vascutek Ltd.

Observational

352

Bologna

2023-03-17

Recruiting

Molecular Characterization of Patients With Acute Myeloid Leukemia and the Impact of Clonal Evolution in the Response to Therapeutic Treatments

NCT06764459Myeloid Leukemia, Acute

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2023-03-15

Active, closed

Solving Challenging Diagnoses Through Ultra-long Read Sequencing

NCT06775613Variant Nucleotide

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2023-03-10

Recruiting

Search for Noninvasive Markers of "Graft Injury" in Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Transplantation

NCT06784440Congenital Heart Disease (CHD), Heart Transplant Patients, Adult Congenital Heart Disease, Pediatric Congenital Heart Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2023-03-08

Active, closed

A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer

NCT05654623Advanced Breast Cancer

DrugsVepdegestrant·Fulvestrant

Pfizer

Phase 3

624

Naples, Misterbianco, Bologna, Cona, Rome, Monza, Ancona, Pisa

2023-03-03

Active, closed

Study to Identify and Describe Predictive Factors for Thromboembolic Events in Patients With High-risk Polycythemia Vera

NCT05548062Polycythemia Vera

Novartis Pharmaceuticals

Observational

242

Alessandria, Ancona, Bari, Bologna, Como, Cosenza, Catania, Florence

2023-03-02

Recruiting

Rapid Processing and Immunohistochemistry Method for Optimising Diagnosis Time in Solid Organ Donors, Suspected Malignancy

NCT06734091Donors, Organ Donor, Organ Transplants

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2023-03-01

Recruiting

The Evaluation of Molecular Markers From PRedittivI DNA of Clinical Outcomes in Patients With UROthelial Tumor

NCT06863844Urothelial Neoplasm

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

210

Bologna

2023-03-01

Recruiting

An Italian Multicenter Retrospective Observational Study to Assess Effectiveness and Safety of Siltuximab for Patients with Castleman's Disease Treated in Italy in a Real-life Context

NCT06720870Castleman Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna, Caserta, Bari, Ferrara, Florence, Milan, Novara, Padova

2023-03-01

Recruiting

Comparison of Custom and Standard Total Knee Replacements

NCT06122727Knee Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2023-03-01

Recruiting

Molecular-genetic Characterization in Patients Undergoing CAR-T Cell Infusion

NCT05807789Hematologic Malignancy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

150

Bologna

2023-02-23

Active, closed

Ultrasound Features of Endometriosis of the Uterosacral Ligaments

NCT06787352Endometriosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

228

Bologna, Siena

2023-02-16

Recruiting

Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation

NCT06813443Cardiomyopathies, Amyloidosis Cardiac, Fabry Disease, Arrhythmogenic Cardiomyopathy

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

700

Bologna, Roma, Florence

2023-02-13

Active, closed

Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma

NCT05605899High-risk Large B-cell Lymphoma (LBCL)

DrugsAxi-cel·Axicabtagene Ciloleucel·Vincristine·Doxorubicin

Kite, A Gilead Company

Phase 3

300

Bologna, Brescia, Milan, Perugia, Reggio Calabria, Rome, Rozzano

2023-02-10

Active, closed

A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

NCT05578976Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone

Genmab

Phase 3

900

Alessandria, Bari, Brescia, Bologna, San Giovanni Rotondo, Milan, Naples, Palermo

2023-02-08

Recruiting

Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial

NCT05496998Mitral Regurgitation

Medtronic Cardiovascular

Not applicable

400

Bologna, Brescia, Milan, Pisa, San Donato Milanese

2023-02-07

Active, closed

Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)

NCT05653349Primary Immune Thrombocytopenia (ITP)

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

226

Bologna, Florence, Roma, Trieste, Vicenza

2023-02-03

Active, closed

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

NCT05686551Huntington Disease

Hoffmann-La Roche

Phase 2

301

Bologna, Rome, Milan

2023-02-03

Active, closed

A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids

NCT05653219Primary Immune Thrombocytopenia

DrugsEltrombopag·Ianalumab

Novartis Pharmaceuticals

Phase 3

152

Bologna, Roma, Trieste

2023-02-02

Recruiting

Post-transplant Thrombotic Microangiopathy: Evaluation of Outcomes at the Bologna Kidney Transplant Centre

NCT06759961Microangiopathy, Kidney Transplant

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

250

Bologna

2023-02-01

Recruiting

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

NCT05580562H3 K27M, Glioma

DrugDordaviprone

Jazz Pharmaceuticals

Phase 3

510

Bologna, Rome, Milan, Rozzano, Turin, Padova

2023-01-23

Recruiting

Tissue Analysis of Liver Grafts as a Predictor of Transplant Outcome.

NCT06717542Hepatic Transplantation, Rejection; Transplant, Liver

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

200

Bologna

2023-01-17

Active, closed

ABTECT - Maintenance

NCT05535946Ulcerative Colitis

DrugObefazimod

Abivax S.A.

Phase 3

1,116

San Giovanni Rotondo, Rho, Rozzano, San Donato Milanese, Negrar, Alessandria, Bologna, Brescia

2023-01-16

Recruiting

Evaluation of the Clinical Outcomes of the Total Knee ps Prosthesis Implanted With the Use of Inertial Sensors

NCT06321042Prosthesis Durability

Istituto Ortopedico Rizzoli

Observational

Bologna

2023-01-13

Recruiting

Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement

NCT06462625Knee Osteoarthritis, Malalignment, Bone

Istituto Ortopedico Rizzoli

Observational

150

Bologna

2023-01-12

Recruiting

Structured Data Collection of Patients Undergoing Liver Transplantation and Evaluated for Bone Mineral Metabolism

NCT06838702Osteoporosis, Liver Transplant

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

150

Bologna

2023-01-11

Active, closed

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

NCT05552976Relapsed or Refractory Multiple Myeloma

DrugsMezigdomide·Carfilzomib·Dexamethasone

Bristol-Myers Squibb

Phase 3

606

Meldola, Milan, Rozzano, Bologna, Catanzaro, Lecce, Pisa, Udine

2023-01-10

Active, closed

Treatment of Crohn's Complex Perianal Fistulas With Tissue Transplantation by Local Injection of Micro-fragmented Autologous Adipose Tissue.

NCT05594862Crohn Disease

Lipogems International spa

Not applicable

Bologna

2023-01-09

Recruiting

Appropriateness of Colonoscopy Indication: an Evaluation of the Clinical and Economic Impact.

NCT06775951Colorectal Cancer Control and Prevention

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,410

Bologna

2023-01-02

Recruiting

Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery

NCT05779670Osteosarcoma, Ewing Sarcoma, Chondrosarcoma, Bone Tumor

Istituto Ortopedico Rizzoli

Observational

Bologna

2023-01-01

Recruiting

ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing

NCT06324682Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation

University Hospital of Ferrara

Observational

8,400

Ferrara, Arezzo, Bologna, Carpi, Cento, Cesena, Empoli, Fidenza

2023-01-01

Active, closed

Robotic vs Open Nephrectomy for ADPKD

NCT07355114Autosomal Dominant Polycystic Kidney Disease (ADPKD)

University of Bologna

Observational

Bologna

2023-01-01

Active, closed

Success and Survival Rate of Tranmucosal Versus Bone Level Implants: Randomized Clinical Trial

NCT06252324Bone Loss

University of Bologna

Not applicable

Bologna

2023-01-01

Active, closed

Survival and Success of Two Different Filling Techniques

NCT06252337Periapical Diseases, Bioceramic Sealers, Survival Rate, Healing Rate

University of Bologna

Not applicable

Bologna

2023-01-01

Active, closed

Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)

NCT05024773Bladder Carcinoma in Situ (CIS)

Fidia Farmaceutici s.p.a.

Phase 3

130

Bergamo, Bologna, Castelfranco Veneto, Florence, Lecce, Milan, Naples, Roma

2022-12-29

Recruiting

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

NCT05712200Atrial Fibrillation (AF)

DrugAbelacimab

Anthos Therapeutics, Inc.

Phase 3

2,500

Ancona, Bologna, Brescia, Cagliari, Caserta, Catanzaro, Cinisello Balsamo, Florence

2022-12-27

Recruiting

Multicenter Italian Cohort Study on Tuberculosis in Pediatric Age

NCT06289660Tuberculosis Infection

Meyer Children's Hospital IRCCS

Observational

1,000

Florence, Bari, Belluno, Bologna, Genova, Milan, Modena, Naples

2022-12-22

Recruiting

European Myeloma Network (EMN) Sample Project

NCT06237803Multiple Myeloma, Smoldering Multiple Myeloma, Plasma Cell Leukemia, Extramedullary Myeloma

European Myeloma Network B.V.

Observational

6,000

Alessandria, Ancona, Bari, Bologna, Brescia, Civitanova Marche, Florence, Genova

2022-12-21

Recruiting

Atezolizumab-bevacizumab and Other Immunotherapies: Real-life Experience for Treatment of Hepatocellular Carcinoma

NCT06806579Hepatocellular Carcinoma (HCC)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,000

Torrette, Castellana Grotte, Bologna, Catania, Foggia, Florence, Modena, Milan

2022-12-21

Recruiting

A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia

NCT05669950Congenital Adrenal Hyperplasia

DrugLu AG13909

H. Lundbeck A/S

Phase 1/2

Bologna, Roma

2022-12-19

Recruiting

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

NCT05232916Breast Cancer

Greenwich LifeSciences, Inc.

Phase 3

2,250

Bologna, Genova, Milan, Modena, Naples, Novara, Padova, Pavia

2022-12-16

Recruiting

Rehabilitation Counselling for Patients with Interstitial Lung Disease

NCT06815185Fibrosis, Pulmonary

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-12-15

Recruiting

Evaluation of the Clinical Utility of Circulating Biomarkers in Advanced Thyroid Carcinomas

NCT06863805Thyroid Carcinoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-12-15

Active, closed

Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial

NCT05581303Atherosclerotic Cardiovascular Disease

DrugOlpasiran

Amgen

Phase 3

7,297

Arzignano, Bologna, Brescia, Caserta, Catania, Catanzaro, Cona FE, Florence

2022-12-14

Active, closed

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)

NCT05469737Myelodysplastic Syndromes

DrugAzacitidine

Bristol-Myers Squibb

Phase 2/3

230

Rome, Rozzano, Florence, Bologna

2022-12-14

Active, closed

A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)

NCT05668988Non-small Cell Lung Cancer

DrugsSunvozertinib·Pemetrexed·Carboplatin

Dizal Pharmaceuticals

Phase 3

324

Aviano, Bologna, Catania, Florence, Grosseto, Meldola, Modena, Monza

2022-12-13

Active, closed

CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

NCT05681351Severe Hypertriglyceridemia

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

885

Bergamo, Bologna, Caserta, Milan, Naples, Palmero, Rome

2022-12-13

Recruiting

Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

NCT05650229Primary Mitochondrial Disease

DrugNapazimone

Pharming Technologies B.V.

Phase 2

180

Bologna, Messina, Milan, Pisa, Roma

2022-12-13

Recruiting

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

NCT05633654Triple Negative Breast Cancer

DrugsXeloda·Sacituzumab Govitecan·Keytruda·Capecitabine

Gilead Sciences

Phase 3

1,514

Bari, Bologna, Florence, Genova, Meldola, Milan, Misterbianco, Modena

2022-12-12

Recruiting

Evaluation of Urinary Biomarkers Trend in Preterm Very Low Birth Weight Infants

NCT06781476Kidney Injury

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-12-07

Recruiting

Pharmacological and Mechanical Support Approaches in the Management of Acute Heart Failure in the Regional Network Model for the Management of Cardiogenic Shock

NCT06827314Cardiogenic Shock, Acute Coronary Event

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

500

Bologna

2022-12-06

Active, closed

Romiplostim Plus Dexamethasone vs Dexamethasone in Patients With Newly Diagnosed Primary Immune Thrombocytopenia

NCT05325593Primary Immune Thrombocytopenia

DrugsRomiplostim·Dexamethasone

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Phase 3

129

Bologna, Milan, Rome

2022-12-02

Active, closed

A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)

NCT05629585Breast Cancer

DrugsDato-DXd·Xeloda·Durvalumab·Keytruda

AstraZeneca

Phase 3

1,174

Bologna, Brescia, Florence, Genova, Livorno, Meldola, Messina, Milan

2022-11-28

Recruiting

TreaT-Assay: the New Frontier for the Diagnosis of Acute Rejection in Kidney Transplantation

NCT06801262Kidney Diseases, Kidney Transplant, Kidney Disease, End-Stage

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

150

Bologna

2022-11-10

Active, closed

Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis

NCT05583227Eosinophilic Esophagitis

DrugTezepelumab

AstraZeneca

Phase 3

368

Bologna, Milan, Naples, Padova, Pisa, Roma, Rozzano, Verona

2022-11-10

Recruiting

A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria

NCT05457283Chronic Kidney Disease, Proteinuria, Children

DrugFinerenone

Bayer

Phase 3

100

Bologna, Florence, Genova, Milan, Roma, Torino

2022-11-08

Active, closed

Circulating and Molecular Markers Involved in the Processes of Cachexia, Anorexia and Sarcopenia in Patients With NSCLC

NCT06808113Non Small Cell Lung Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-11-07

Active, closed

Xeltis Hemodialysis Access Graft: aXess Pivotal Study

NCT05473299End-stage Renal Disease

Xeltis

Not applicable

120

Ancona, Bari, Bologna, Padova, Varese

2022-11-04

Recruiting

Study of Epigenetic and Inflammatory Markers of Accelerated Biological Ageing in the Follow up of Patients With Hodgkin's Lymphoma

NCT06761274Hodgkin Lymphoma in Remission

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

200

Bologna

2022-11-03

Active, closed

A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight

NCT05567796Obesity

DrugsCagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

3,400

Bari, Catanzaro, San Donato Milanese (MI), Roma, Siena, Bologna, Catania, Padova

2022-11-01

Recruiting

PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT

NCT04937998Patellofemoral Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

166

Bologna

2022-10-26

Active, closed

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma

NCT05169515Non-Hodgkin Lymphoma

DrugsGolcadomide·Iberdomide·Mosunetuzumab·Glofitamab

Hoffmann-La Roche

Phase 1

121

Bologna, Meldola, Milan, Pisa

2022-10-26

Recruiting

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

NCT05208762Carcinoma, Non-Small-Cell Lung, Squamous Cell Carcinoma of the Head and Neck, Esophageal Squamous Cell Carcinoma, Triple Negative Breast Neoplasms

DrugsPF-08046054·Keytruda·Pembrolizumab

Seagen, a wholly owned subsidiary of Pfizer

Phase 1

714

Milan, Verona, Bologna

2022-10-25

Recruiting

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

NCT05552222Multiple Myeloma

DrugsTalquetamab·Teclistamab·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,590

Bergamo, Bologna, Florence, Milan, Naples, Pavia, Roma, Rozzano

2022-10-25

Recruiting

The Italian Registry of Malnutrition in Oncology

NCT06337019Cancer, Cancer Metastatic

Fondazione IRCCS Policlinico San Matteo di Pavia

Observational

1,500

Bari, Castellana Grotte, Bologna, Meldola, Genova, Milan, Aviano, Padova

2022-10-25

Recruiting

National Database on Primary Sclerosing Cholangitis (PSC)

NCT05618145Primary Sclerosing Cholangitis

University of Milano Bicocca

Observational

6,000

Ancona, Bari, Bergamo, Bologna, Bolzano, Brescia, Cagliari, Castellana Grotte

2022-10-21

Active, closed

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05259839Relapsed/Refractory Multiple Myeloma

DrugsEtentamig·Pomalidomide·Daratumumab·Lenalidomide

AbbVie

Phase 1

283

Meldola, Milan, Rome, Bologna

2022-10-20

Recruiting

Sarcopenia and Systemic Therapy in HCC

NCT06805552HCC - Hepatocellular Carcinoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

270

Bologna

2022-10-19

Active, closed

A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma

NCT05535244Multiple Myeloma

DrugsCevostamab·Tocilizumab

Hoffmann-La Roche

Phase 1/2

Bologna, Bergamo, Milan, Turin

2022-10-17

Recruiting

Diagnosis and Percutaneous Treatment of Biliary Tract Diseases

NCT06816615Gallstone, Biliary Stricture, Biliary Diseases

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2022-10-14

Active, closed

A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment

NCT05455320Multiple Myeloma

DrugsTalquetamab·Pomalidomide·Daratumumab·Dexamethasone

Janssen Research & Development, LLC

Phase 3

864

Ancona, Bari, Bologna, Brescia, Catania, Milan, Padova, Palermo

2022-10-13

Active, closed

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

NCT05556512Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

15,374

Bari, Bologna, Como, Ferrara, Florence, Latina, Padova, Palermo

2022-10-11

Active, closed

Overcoming Resistance to EGFR Neutralization by Combination of Monoclonal Antibodies and Novel Cancer Drugs

NCT06863818Non Small Cell Lung Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-10-10

Active, closed

The Role of miRNA in Group 3 Pulmonary Hypertension

NCT06714136Pulmonary Hypertension

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-10-10

Recruiting

Use of Leukocyte-Rich PRP or Leukocyte-Free PRP in the Treatment of Hip Osteoarthritis

NCT05497349Hip Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

230

Bologna

2022-10-05

Active, closed

Ponatinib Plus Chemotherapy in Acute Lymphoblastic Leukemia Patients

NCT05306301Chemotherapy, Leukemia, Acute Lymphoblastic

DrugPonatinib

Gruppo Italiano Malattie EMatologiche dell'Adulto

Phase 2

Avellino, Pagani, Bergamo, Bologna, Brescia, Catania, Florence, Lecce

2022-10-05

Active, closed

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

NCT05514054Breast Neoplasms

DrugsImlunestrant·Tamoxifen·Exemestane·Anastrozole

Eli Lilly and Company

Phase 3

8,000

Ancona, Bergamo, Bologna, Brindisi, Candiolo, Florence, Genova, Milan

2022-10-04

Active, closed

A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies

NCT05453903Leukemia, Myeloid, Acute

DrugsBleximenib·Idarubicin·Daunorubicin·Cytarabine

Janssen Research & Development, LLC

Phase 1

196

Bologna, Meldola, Milan, Rozzano

2022-10-04

Active, closed

Broncho-Vascular Lung Sparing Reconstructions and Pneumonectomies in Patients With Non Small Cell Lung Cancer

NCT06835231Lung Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

140

Bologna

2022-10-01

Recruiting

A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies

NCT05443126NSCLC

DrugPemetrexed

Ellipses Pharma

Phase 1/2

265

Aviano, Bologna, Milan, Roma, Torino

2022-09-30

Active, closed

Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma

NCT05371093Relapsed/Refractory Follicular Lymphoma

DrugsAxi-cel·Axicabtagene Ciloleucel·Bendamustine·Vincristine

Kite, A Gilead Company

Phase 3

231

Bergamo, Bologna, Milan, Reggio Emilia, Rozzano

2022-09-22

Recruiting

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT05519085Relapsed or Refractory Multiple Myeloma

DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib

Celgene

Phase 3

810

Meldola, Rome, Catania, Bologna, Pavia

2022-09-20

Active, closed

CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma

NCT05440786Sarcoma, Ewing, Neoplasm Metastasis

DrugsAbemaciclib·Temozolomide·Irinotecan

Eli Lilly and Company

Phase 2

Rome, Bologna

2022-09-20

Active, closed

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

NCT05531565Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus

DrugLitifilimab

Biogen

Phase 2/3

450

Bologna, Brescia, Florence, Genova, Milan, Naples, Roma

2022-09-13

Recruiting

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

NCT05243797Multiple Myeloma

DrugsTeclistamab·Lenalidomide

European Myeloma Network B.V.

Phase 3

1,594

Alessandria, Ancona, Bari, Bergamo, Bologna, Brescia, Cagliari, Cosenza

2022-09-08

Recruiting

Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.

NCT05553873Myeloproliferative Disease, Inflammatory Markers

University of Milano Bicocca

Observational

500

Bari, Bologna, Brescia, Catania, Naples, Roma, Torino, Udine

2022-09-08

Recruiting

Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial

NCT05334368Hypereosinophilic Syndrome

DrugDepemokimab

GlaxoSmithKline

Phase 3

109

Bologna, Catania, Milan, Naples, Novara, Pavia, Roma, Treviso

2022-09-06

Recruiting

Hyperthyroidism as a Potential Predictive of Worse Outcome of Renal Graft

NCT06794203Kidney Diseases, Kidney Transplant, Hyperthyroidism

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2022-09-02

Recruiting

Comparison Between Whole Body DWI and FDG PET/CT in Patients with Simptomatic Multiple Myeloma

NCT06659276Multiple Myeloma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-09-01

Recruiting

Canadian TIA Score Versus ABCD2 Score in Risk Stratification of Transient Ischemic Attack (TIA)

NCT06718075Transient Ischemic Attack (TIA)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

800

Bologna

2022-09-01

Active, closed

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

NCT05492578Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2/3

1,856

Milan, Rozzano, Naples, Rome, Turin, Bologna, Catania, Chieti

2022-08-22

Active, closed

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

NCT05327530Locally Advanced or Metastatic Urothelial Carcinoma

DrugsAvelumab·Sacituzumab Govitecan

EMD Serono Research & Development Institute, Inc.

Phase 2

256

Bologna, Florence, Forlì, Milan, Misterbianco, Naples, Padova, Pisa

2022-08-17

Active, closed

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

NCT05388669Advanced or Metastatic Non-small Cell Lung Cancer

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 3

418

Bari, Bologna, Milan, Orbassano, Padova, Ravenna, Roma, Rome

2022-08-05

Recruiting

Evaluation of the Correlation Between Vein Size Inferior Cava and Right Atrial Pressure in Pediatric Age and Creation of a Possible Predictive Model

NCT06776133Congenital Heart Disease, Acquired Heart Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,100

Bologna

2022-08-01

Active, closed

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

NCT05382286Triple Negative Breast Cancer, PD-L1 Positive

DrugsAbraxane·Sacituzumab Govitecan·Taxol·Nab-paclitaxel

Gilead Sciences

Phase 3

443

Bari, Bologna, Brescia, Genova GE, Lecco, Lucca, Milan, Monza

2022-07-25

Recruiting

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma

DrugsPirtobrutinib·Ibrutinib

Loxo Oncology, Inc.

Phase 3

737

Alessandria, Bologna, Meldola, Milan, Reggio Emilia

2022-07-22

Active, closed

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

NCT05458297Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma

DrugsZilovertamab vedotin·Nemtabrutinib

Merck Sharp & Dohme LLC

Phase 2

189

Bologna, Rozzano, Alessandria, Roma

2022-07-21

Active, closed

Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

NCT05382299Triple Negative Breast Cancer, PD-L1 Negative

DrugsAbraxane·Sacituzumab Govitecan·Nab-paclitaxel·Gemcitabine

Gilead Sciences

Phase 3

623

Bari, Bologna, Brescia, Genova GE, Lecco, Lucca, Milan, Monza

2022-07-20

Recruiting

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

NCT05475925LGLL - Large Granular Lymphocytic Leukemia, Primary Cutaneous Gamma-Delta T-Cell Lymphoma, Primary Cutaneous CD8+ Aggressive Epidermotropic T-Cell Lymphoma, Hepatosplenic T-cell Lymphoma

DrugDibotatug

Dren Bio

Phase 1/2

200

Bologna

2022-07-13

Recruiting

Gut Microbiota Analysis in Patients Undergoing Duodencephalopancreasectomy for Pancreatic Cancer

NCT06800469Pancreatic Cancer, Adult

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

Bologna

2022-07-11

Active, closed

A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy

NCT05337553Spinal Muscular Atrophy, Neuromuscular Diseases, SMA

DrugTaldefgrobep alfa

Biohaven Pharmaceuticals, Inc.

Phase 3

269

Bologna, Gussago, Pavia, Roma

2022-07-06

Recruiting

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

NCT05203172Solid Tumors

DrugsVemurafenib·Binimetinib·Encorafenib·Zirabev

Pfizer

Phase 4

210

Bari, Perugia, Rome, Candiolo, Padova, Bologna, Milan, Naples

2022-07-05

Recruiting

Impact of Different BRCA1/2 Gene Variants on Response to Therapy and Prognosis of Ovarian Cancer

NCT06775470Ovarian Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

300

Bologna

2022-07-01

Recruiting

Validation of the Italian Version of the Forgotten Joint Score (FJS-12) in Total Ankle Replacement

NCT06091397PROMs, Total Ankle Replacement, Italian Forgotten Joint Score

Istituto Ortopedico Rizzoli

Observational

120

Bologna

2022-07-01

Recruiting

Non Invasive Measurement With Trans Cranial Doppler Versus Invasive Measurement in Pediatric Age

NCT05340062Intracranial Hypertension

Azienda Ospedaliera di Padova

Observational

Bologna, Brescia, Florence, Genova, Padova, Roma

2022-07-01

Recruiting

Arthrorisis of the Subtalar Joint With a Polymeric Endorthesis for Flexible Flatfoot Treatment During the Growth Age Prospective Evaluation

NCT06091371Subtalar Arthrorisis, Flat Feet, Growth Age

Istituto Ortopedico Rizzoli

Observational

Bologna

2022-07-01

Active, closed

(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis

NCT05186753SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis

DrugBezuclastinib

Cogent Biosciences, Inc.

Phase 2

237

Bologna, Catania, Florence, Pavia, Ravenna

2022-06-27

Recruiting

Electronic Registry of Male Patients With Congenital Adrenal Hyperplasia 21-hydroxylase Deficiency

NCT06754423Congenital Adrenal Hyperplasia

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-06-24

Active, closed

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT04975997Multiple Myeloma

DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone

Celgene

Phase 3

939

Rome, Bologna, Catania, Genova, Milan, Novara, Pavia, Pisa

2022-06-23

Active, closed

SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM

NCT05405166Plasma Cell Myeloma Recurrent

DrugsParacetamol / Acetaminophen·Montelukast·Diphenhydramine·Isatuximab

Sanofi

Phase 3

531

Torette, Meldola, Rome, Bologna, Brescia, Pavia

2022-06-23

Active, closed

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

NCT04970901B-Cell Non-Hodgkin Lymphoma, Relapsed B-Cell Non-Hodgkin Lymphoma, Refractory B-Cell Non-Hodgkin Lymphoma

DrugsLoncastuximab Tesirine·Mosunetuzumab·Polatuzumab Vedotin·Glofitamab

ADC Therapeutics S.A.

Phase 1

154

Bergamo, Bologna, Brescia, Milan

2022-06-17

Recruiting

An Observational Study of Local Relapse After High Grade Osteosarcoma

NCT06017518Osteosarcoma

Istituto Ortopedico Rizzoli

Observational

150

Bologna, Pisa

2022-06-13

Recruiting

Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib

NCT05280509Myelofibrosis, Primary Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis

DrugsJakavi·Ruxolitinib

Telios Pharma, Inc.

Phase 1/2

Bologna, Milan, Perugia

2022-06-09

Active, closed

BIVV020 (SAR445088) in Prevention and Treatment of Antibody-mediated Rejection (AMR)

NCT05156710Transplant Rejection

DrugsAntithymocyte globulin·Riliprubart·Immunoglobulin·IVIG

Sanofi

Phase 2

Bologna, Rome, Brescia, Milan

2022-06-09

Active, closed

Pixantrone as Bridging Therapy to Allogenic Transplant or CAR-T Cell Therapy in DLBCL Patients

NCT06760936Diffuse Large B Cell Lymphoma (DLBCL)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-06-06

Recruiting

A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)

NCT05813678Phenylketonuria (PKU)

DrugPegvaliase

BioMarin Pharmaceutical

Observational

450

Bologna, Florence, Milan, Naples, Padova, Palermo, Rome

2022-06-06

Recruiting

Risk Factors Associated With the Progression of Adenomyosis

NCT06718088Adenomyosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

258

Bologna

2022-06-01

By invitation

Customized Bone Allografts by 3D-printing

NCT05700526Musculoskeletal Deformity, Musculoskeletal Diseases, Musculoskeletal Disorder

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2022-06-01

Recruiting

A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

NCT05183646FSGS

DrugRepagermanium

Dimerix Bioscience Pty Ltd

Phase 3

286

Bari, Bologna, Genova, Milan, Pavia, Roma, Torino

2022-05-30

Recruiting

Durvalumab With Carboplatin and Etoposide Chemotherapy in Pulmonary Large-cell Neuroendocrine Carcinoma (LCNEC)

NCT06418087Pulmonary Large-cell Neuroendocrine Carcinoma

DrugDurvalumab

Gruppo Oncologico Italiano di Ricerca Clinica

Phase 2

Bologna, Viagrande, Meldola, Florence, Rozzano, Padova, Aviano, Roma

2022-05-27

Recruiting

Role of Exosomes in Pancreatic Cancer Progression

NCT06777030Pancreatic Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-05-22

Recruiting

Comparison of Cervical Cerclage by Vaginal and by Laparoscopic Transabdominal Routes in the Periconceptional Period

NCT06788873Cerclage, Cervical

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-05-15

Recruiting

Fibrous Dysplasia: An Epidemiological and Correlational Evaluation of Multimodal Data

NCT07569731Fibrous Dysplasia, Fibrous Dysplasia of Bone, Fibrous Dysplasia/McCune-Albright Syndrome, Mazabraud Syndrome

Istituto Ortopedico Rizzoli

Observational

200

Bologna

2022-05-12

Recruiting

Ruxolitinib in Primary Myelofibrosis and Secondary to Essential Thrombocythemia or Polycythemia Vera

NCT06516406Myelofibrosis, Primary Myelofibrosis, Secondary Myelofibrosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,055

Cosenza, Reggio Calabria, Naples, Bologna, Ferrara, Parma, Piacenza, Ravenna

2022-05-06

Active, closed

A Study to Evaluate the Effect of Venglustat Tablets on Left Ventricular Mass Index in Male and Female Adult Participants With Fabry Disease

NCT05280548Fabry Disease

DrugsAgalsidase beta·Replagal·Venglustat·Migalastat HCl

Sanofi

Phase 3

104

Milan, Naples, Bologna

2022-05-03

By invitation

Single-institution Register of Individuals Undergoing Cancer Genetic Risk Assessment

NCT06800599Genetic Predisposition to Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

7,000

Bologna

2022-05-01

Recruiting

Carbofix Pedicle Screw System: Evaluation of the Clinical and Radiographic Outcomes of the Use of a Carbon Fiber Device Compared to Titanium Devices in Patients Undergoing Spinal Arthrodesis for Degenerative Spinal Diseases

NCT06209684Degenerative Disc Disease

Istituto Ortopedico Rizzoli

Not applicable

118

Bologna

2022-04-29

Recruiting

Study in Patients With Relapsed/Refractory Primary Mediastinal Lymphoma Treated With Pembrolizumab or Nivolumab in Combination With Brentuximab Vedotin in a Real-life Context

NCT06781450Primary Mediastinal B Cell Lymphoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna, Bari, Milan

2022-04-23

Recruiting

Can Hepatic-splenic Elastography Predict the Risk of Hepatocellular Recurrence After Radiofrequency Ablation?

NCT06777017HCC - Hepatocellular Carcinoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-04-22

Recruiting

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

NCT05208047Advanced Gastrointestinal Stromal Tumors, Metastatic Cancer

DrugsBezuclastinib·Sunitinib·Midazolam

Cogent Biosciences, Inc.

Phase 3

482

Aviano, Bologna, Brescia, Candiolo, Florence, Meldola, Milan, Palermo

2022-04-14

Recruiting

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

NCT05131022Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)

DrugBexobrutideg

Nurix Therapeutics, Inc.

Phase 1

572

Bologna, Brescia, Milan, Rome

2022-04-13

Recruiting

Electrochemotherapy With Carboplatinum Plus Bleomycin Versus Bleomycin Alone in Vulvar Cancer

NCT05395962Vulvar Cancer

DrugsBleomycin·Carboplatin

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Phase 2

Bologna

2022-04-08

Active, closed

Predictive Value of SFlt-1/PlGF Ratio for the Diagnosis of Cardiovascular Disorders in the Puerperium: Pilot Study

NCT06720857Cardiovascular Disorder, Puerperium; Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Not applicable

181

Bologna

2022-04-06

By invitation

Trial of Sibeprenlimab in the Treatment of Immunoglobulin A Nephropathy (IgAN)

NCT05248659Immunoglobulin A Nephropathy

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 2/3

600

Bologna, Genova, Pavia, Piacenza

2022-04-05

Recruiting

Validation and Optimisation of Ultrasound Diagnosis of Adenomyosis

NCT06795711Adenomyosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

465

Bologna

2022-04-04

Recruiting

Survey of Different Modes of Weaning in Pediatric Population

NCT06839846Weaning

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

500

Imola, Carpi, Bologna

2022-04-01

Recruiting

Triphasic Osteochondral Scaffold for the Treatment of the OCD of the Knee: Observational Study

NCT05332288Osteochondritis Dissecans Knee

Istituto Ortopedico Rizzoli

Observational

Bologna

2022-04-01

Active, closed

A Phase 3 Study of Rusfertide in Patients With Polycythemia Vera

NCT05210790Polycythemia Vera

DrugRusfertide

Protagonist Therapeutics, Inc.

Phase 3

293

Meldola, Bergamo, Bologna, Brescia, Florence, Milan, Pavia, Pesaro

2022-04-01

Active, closed

A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria

NCT05196035Chronic Kidney Disease, Proteinuria

DrugFinerenone

Bayer

Phase 3

219

Bologna, Florence, Genova, Milan, Roma, Torino

2022-03-28

Active, closed

MaaT013 As Salvage Therapy in Ruxolitinib Refractory GI-aGVHD Patients

NCT04769895Acute Graft Versus Host Disease in Intestine, Steroid Refractory GVHD

MaaT Pharma

Phase 3

Ancona, Bologna, Genova, Milan, Reggio Calabria, Roma, Torino, Udine

2022-03-25

Active, closed

Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant

NCT05317416Multiple Myeloma

DrugsElranatamab·Lenalidomide

Pfizer

Phase 3

854

Meldola, Rome, Milan, Catania, Siena, Ancona, Bologna, Roma

2022-03-25

By invitation

18F-FDG PET/TC in TIR3A e TIR3B

NCT06829043PET / CT, FDG PET/CT, Cytology, Thyroid Nodules

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

216

Bologna

2022-03-22

Active, closed

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

NCT05239728Carcinoma, Renal Cell

DrugsBelzutifan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

1,800

Bari, Meldola, Rome, Milan, Orbassano, Florence, Arezzo, Bologna

2022-03-15

Active, closed

Trial of Sibeprenlimab in the Treatment of A Nephropathy (IgAN)

NCT05248646Immunoglobulin A Nephropathy

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 3

530

Bologna, Brescia, Florence, Genova, Messina, Milan, Naples, Pavia

2022-03-15

Active, closed

A Study to Evaluate the Effect of Venglustat Tablets on Neuropathic and Abdominal Pain in Male and Female Participants ≥16 Years of Age With Fabry Disease

NCT05206773Fabry Disease

DrugVenglustat

Sanofi

Phase 3

122

Bologna, Monza, Naples, Palermo, Roma

2022-03-11

Active, closed

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

NCT05100862Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma

DrugsRuxience·Truxima·Zanubrutinib·Obinutuzumab

BeOne Medicines

Phase 3

799

Aviano, Bologna, Florence, Milan, Novara, Padova, Pavia, Reggio Emilia

2022-03-10

Recruiting

Clinical Significance and Prognostic Value of Prenatal Diagnosis of Obliteration of the Cavum Septum Pellucidum

NCT06782802Fetal Neurodevelopmental Disorder, Cavum Septum Pellucidum

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-03-07

Recruiting

Integrative "Omics" Approaches for Leukemia Target Identification and Matched Therapeutic Intervention

NCT06626893Myeloid Leukemia, Acute, Leukemia, Acute Lymphoblastic

DrugFunctional tests

Azienda Ospedaliero-Universitaria di Parma

Not applicable

100

Meldola, Bologna, Ferrara, Parma, Piacenza, Ravenna, Reggio Emilia, Rimini

2022-03-01

Recruiting

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

NCT04988555Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute, Multiple Myeloma, Myelodysplastic Syndromes

DrugsAzoles·Gilteritinib·Azacitidine·Venetoclax

Sumitomo Pharma America, Inc.

Phase 1/2

606

Bologna, Busto Arsizio, Genoa, Meldola, Padua, Perugia, Ravenna, Rome

2022-02-28

Recruiting

Pilot Study of Percutaneous Correction of Hallux Valgus

NCT05880407Hallux Valgus

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2022-02-22

Active, closed

Setrusumab vs Placebo for Osteogenesis Imperfecta

NCT05125809Osteogenesis Imperfecta

DrugSetrusumab

Ultragenyx Pharmaceutical Inc

Phase 2/3

183

Bologna, Rome, Verona

2022-02-21

Recruiting

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

NCT05128825High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

DrugAzenosertib

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 2

310

Naples, Modena, Aviano, Rome, Milan, Verona, Bologna

2022-02-17

Recruiting

Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis

NCT04998188Knee Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

204

Bologna

2022-02-16

Active, closed

Unraveling the Role of Extracellular Vesicles-driven Senescence in Myeloproliferative Neoplasms

NCT06798805Essential Thrombocythemia (ET), Myelofibrosis (MF), Polycythemia Vera (PV)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

110

Bologna, Brescia, Meldola, Ravenna, Reggio Emilia

2022-02-15

Active, closed

177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer

NCT05204927Metastasis From Malignant Tumor of Prostate

DrugEnzalutamide

Curium US LLC

Phase 3

439

Bologna, Milan

2022-02-14

Recruiting

Outcomes of Surgical Treatment Using a Custom-made Device for Total Ankle and Talar Replacement in the Management of Severe Cases of Bone Loss or Bone Compromise: a Pilot Study.

NCT07569848Arthrosis, Ankle Arthritis, Ankle Replacement

Istituto Ortopedico Rizzoli

Observational

Bologna

2022-02-11

Active, closed

Retrospective Study to Evaluate the Effectiveness of the Approach to Enuresis in Our Center

NCT06764498Enuresis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

200

Bologna

2022-02-10

Recruiting

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

NCT04779320Crohn's Disease (CD)

DrugVedolizumab

Takeda

Phase 3

120

Naples, Bologna, Rome, Monza, Padova

2022-02-10

Active, closed

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)

NCT05173987Endometrial Neoplasms

DrugsTaxotere·Paraplatin·Taxol·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

280

Naples, Bologna, Meldola, Milan, Turin, Rome, Florence, Vicenza

2022-02-03

Recruiting

Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers

NCT04858217Prosthetic Joint Infection

Istituto Ortopedico Rizzoli

Observational

270

Bologna

2022-02-01

Recruiting

Retrospective Observational Study of Italian Cohort of Lymphoma Patients (RETRO-LYMPH)

NCT06781437Lymphoproliferative Syndrome, Autoimmune, Lymphoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

5,500

Bologna

2022-02-01

Recruiting

Italian Anderson Fabry Disease Cardiovascular Registry

NCT06806813Fabry Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

800

Chieti, Potenza, Caserta, Catanzaro, Cosenza, Bologna, Genova, Bergamo

2022-01-26

Active, closed

A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease

NCT05197049Crohn Disease

DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3

Janssen Research & Development, LLC

Phase 3

350

Bologna, Milan, Roma

2022-01-19

Recruiting

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

NCT05139017DLBCL, Diffuse Large B-Cell Lymphoma

DrugsZilovertamab vedotin·Granulocyte Colony-Stimulating Factor·Riabni·G-Csf

Merck Sharp & Dohme LLC

Phase 2/3

290

Rozzano, Bologna, Naples, Roma

2022-01-14

Recruiting

Central Awareness in Women With Endometriosis

NCT06773065Endometriosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

310

Bologna

2022-01-14

Recruiting

Soft Tissue Prediction in Orthognathic Surgery by Making Anatomically Accurate Virtual Model

NCT06714747Orthognathic Surgery

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-01-11

Recruiting

International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors

NCT05363657Kidney Cancer

Azienda Ospedaliero-Universitaria Careggi

Observational

10,000

Bari, Bologna, Florence, Foggia, Genova, Messina, Milan, Naples

2022-01-10

Recruiting

Severe Acquired Brain Injuries: Prognostic Factors and Quality of Care

NCT04905264Brain Injuries, Acute

Mario Negri Institute for Pharmacological Research

Observational

2,500

Alessandria, Arezzo, Baggiovara, Bergamo, Bologna, Brescia, Cagliari, Correggio

2022-01-03

Recruiting

Establishment of a Registry of Patients With Parathyroid Disease

NCT06797934Hyperparathyroidism, Hypoparathyroidism

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,200

Bologna

2022-01-03

Active, closed

Electronic Archive of Patients With Congenital Heart Disease and Diagnosis of Infective Endocarditis

NCT06777615Congenital Heart Disease (CHD), Infective Endocarditis (IE)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2022-01-01

Recruiting

Evaluation of Different Diagnostic Therapeutic Strategies in Patients with Thyroid Pathology

NCT06779747Hypothyroidism, Hyperthyroidism/Thyrotoxicosis, Thyroid Nodule (Benign), Thyroid Carcinoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

5,850

Bologna

2021-12-30

Recruiting

Patients With Tuberculosis, Mycobacteriosis or Latent Tuberculosis

NCT06764576Mycobacterial Infection, Tuberculosis (TB)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

13,000

Bologna

2021-12-19

Recruiting

Registry of Adjuvant Hormone-blockade Breast Cancer Patients Evaluated for Bone Mineral Metabolism

NCT06773533Breast Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

3,000

Bologna

2021-12-18

Active, closed

Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.

NCT05038735Breast Cancer

DrugsAlpelisib·Fulvestrant

Novartis Pharmaceuticals

Phase 3

210

Bari, Bergamo, Bologna, Florence, Genova, Milan, Rozzano, Palermo

2021-12-17

Recruiting

Correlation Between the Change in the Antero-posterior Diameter of the Pelvic Side and the Incidence of Post-partum Urinary Incontinence

NCT06812806Postpartum Urinary Incontinence

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

240

Bologna

2021-12-17

Recruiting

A Study of Elritercept Alone or Together With Ruxolitinib in Adults With Myelofibrosis

NCT05037760Myelofibrosis

DrugsElritercept·Ruxolitinib

Takeda

Phase 2

135

Bari, Bologna, Brescia, Florence, Genova, Milan, Reggio Emilia, Roma

2021-12-16

Recruiting

Homologous PRP vs Placebo in Knee Osteoarthritis in Over 65 Years Old Patients

NCT04901273Knee Osteoarthritis

Istituto Ortopedico Rizzoli

Not applicable

204

Bologna

2021-12-15

Recruiting

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

NCT05176483Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC), Urothelial Carcinoma (UC), Solid Tumor

DrugsZanzalintinib·Relatlimab·Yervoy·Ipilimumab

Exelixis

Phase 1

1,394

Ancona, Bologna, Florence, Milan, Naples, Ravenna

2021-12-14

Active, closed

Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).

NCT05116189Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

DrugsZirabev·Taxotere·Avastin·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

643

Bologna, Milan, Monza, Turin, Brescia

2021-12-13

Recruiting

Epidemiological Study on Invasive Bacterial Diseases

NCT06322290Invasive Bacterial Diseases (IBD)

Meyer Children's Hospital IRCCS

Observational

5,000

Adria, Ancona, Andria, Bari, Bologna, Brescia, Campobasso, Camposampiero

2021-12-09

Active, closed

EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke

NCT05029414Acute Ischemic Stroke

University Hospital, Basel, Switzerland

Not applicable

543

Bologna, Florence, Naples, Torino

2021-12-09

Recruiting

Italian Study of Patients With Lymphoma

NCT06814925Lymphoma

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,500

Bologna

2021-12-07

Active, closed

Trial in AML Secondary to MPNs Patients, Unfit for Intensive Chemotherapy, Investigating a Treatment Combination Including Decitabine and Venetoclax

NCT04763928Acute Myeloid Leukemia

DrugsDecitabine·Venetoclax

Gruppo Italiano Malattie EMatologiche dell'Adulto

Phase 2

101

Alessandria, Ancona, Bari, Bergamo, Bologna, Brescia, Cagliari, Castelfranco Veneto

2021-12-03

Active, closed

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

NCT05152147Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma

DrugsZanidatamab·Herceptin·Trastuzumab·Adrucil

Jazz Pharmaceuticals

Phase 3

920

Bologna, Candiolo, Genova, Meldola, Milan, Modena, Reggio Emilia, Rome

2021-12-02

Recruiting

Twenty Years' Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center

NCT06806917Testicular Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna, Milan

2021-12-01

Active, closed

Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

NCT04910022Glioblastoma, Diffuse Glioma

DrugsNMS-03305293·Temozolomide

Nerviano Medical Sciences

Phase 1/2

150

Bologna, Milan, Padova, Rozzano

2021-12-01

Recruiting

International Survey of Acute Coronavirus Syndromes-COVID-19

NCT05188612COVID-19

University of Bologna

Observational

10,000

Bologna

2021-12-01

Recruiting

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis

Blueprint Medicines Corporation

Phase 2/3

534

Milan, Florence, Bologna, Catania, Pavia, Salerno, Verona, Vicenza

2021-11-30

Active, closed

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

NCT05030428Atherosclerotic Cardiovascular Disease

DrugInclisiran sodium

Novartis Pharmaceuticals

Phase 3

17,004

Bologna, Brescia, Cona, Florence, Grosseto, Pozzilli, Milan, Rozzano

2021-11-23

Recruiting

Patients With Diabetes Mellitus on Drug Treatment on the List or Already Undergoing Orthotopic Liver Transplantation

NCT06816303Diabetes Mellitus Type 2, Liver Transplant

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna

2021-11-19

Active, closed

Registry for Patients Undergoing Penile Prosthesis Implantation for Male Erectile Dysfunction

NCT03849586Erectile Dysfunction

European Association of Urology Research Foundation

Observational

1,076

Bologna, Foggia, Parma

2021-11-19

Recruiting

Recurrence Rate After Endoscopic Resection of , Laterally Spreading Tumor Granular Type (LST-G) of the Colon and Rectum: Endoscopic Mucosal Resection vs. Endoscopic Submucosal Dissection

NCT06815406Colorectal Cancer

Azienda USL Reggio Emilia - IRCCS

Not applicable

282

Bologna, Genova, Milan, Modena, Reggio Emilia

2021-11-18

Recruiting

A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma

NCT05160584Relapsed/Refractory Multiple Myeloma

Janssen Pharmaceutica N.V., Belgium

Observational

300

Bari, Bologna, Catania, Civitanova Marche, Genova, Lecce, Meldola, Padova

2021-11-18

Recruiting

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

NCT04996875Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN), Mast Cell Leukemia (MCL), Aggressive Systemic Mastocytosis (ASM)

DrugBezuclastinib

Cogent Biosciences, Inc.

Phase 2

140

Bologna, Florence, Salerno, Verona

2021-11-09

Active, closed

Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia

NCT04994717Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)

DrugBlinatumomab

Amgen

Phase 3

303

Bari, Bergamo, Bologna, Genova, Lecce, Mestre (VE), Milan, Naples

2021-11-02

Recruiting

Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

NCT04383119Leiomyosarcoma of Ovary, Soft Tissue Sarcoma

DrugsTrabectedin·Gemcitabine

Italian Sarcoma Group

Phase 2

100

Bologna, Meldola, Prato, Rozzano, Aviano, Roma, Candiolo, Orbassano

2021-10-29

Recruiting

Assessment of Different Therapeutic Strategies in Patients With Head and Neck Neoplasms Treated With Radiotherapy

NCT06773039Head and Neck Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

3,000

Bologna

2021-10-28

Active, closed

Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable and Locally Advanced or Metastatic PRCC

NCT05043090Papillary Renal Cell Carcinoma

DrugsSavolitinib·Sunitinib·Durvalumab

AstraZeneca

Phase 3

148

Arezzo, Avellino, Bari, Bologna, Florence, Meldola, Milan, Naples

2021-10-28

Active, closed

A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma

NCT04712097Relapsed or Refractory Follicular Lymphoma

DrugsMosunetuzumab·Lenalidomide·Rituximab

Hoffmann-La Roche

Phase 3

478

Bologna, Ravenna, Palermo, Ancona, Florence, Padova

2021-10-27

Active, closed

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

NCT05113251Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer

DrugsHerzuma·Perjeta·Herceptin·Adriamycin

AstraZeneca

Phase 3

927

Bologna, Candiolo, Livorno, Milan, Naples, Negrar, Padova, Roma

2021-10-25

Recruiting

Assessment of ADC Values and Radiomics Characteristics With a MRI of the Prostate to Identify Tumor Lesions

NCT06774781Prostate Cancer (Adenocarcinoma)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

120

Bologna

2021-10-23

Active, closed

A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET

NCT05050942Gastro-enteropancreatic Neuroendocrine Tumor

DrugsCAM2029·Octreotide LAR

Camurus AB

Phase 3

332

Bari, Bologna, Brescia, Florence, Genova, Meldola, Milan, Modena

2021-10-22

Active, closed

Renal and Urinary Manifestations of Chronic Inflammatory Bowel Diseases.

NCT06814392IBD - Inflammatory Bowel Disease

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,600

Bologna

2021-10-20

Active, closed

Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)

NCT05082454Aortic Valve Disease

JOTEC GmbH

Observational

108

Bologna

2021-10-20

Active, closed

A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)

NCT05104866Breast Cancer

DrugsEribulin·Dato-DXd·Vinorelbine·Capecitabine

AstraZeneca

Phase 3

732

Bologna, Candiolo, Florence, Meldola, Milan, Naples, Padova, Prato

2021-10-18

Active, closed

Study of Vimseltinib for Tenosynovial Giant Cell Tumor

NCT05059262Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse

DrugVimseltinib

Deciphera Pharmaceuticals, LLC

Phase 3

123

Bologna, Milan, Naples, Padua, Rome

2021-10-14

Active, closed

Clinical Outcome After Episealer Talus Implant in Treatment of Osteochondral Lesion of the Talus

NCT06522139Osteochondral Defect

Stefano Zaffagnini

Not applicable

Bologna

2021-10-14

Active, closed

A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05083169Multiple Myeloma

DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab

Janssen Research & Development, LLC

Phase 3

587

Bari, Bergamo, Bologna, Florence, Meldola, Pavia, Roma, Turin

2021-10-14

Recruiting

The Role of Ultrasonography in Pregnancy in the Study of Fetal Central Nervous System Malformations

NCT06788808Malformation Brain

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Bologna

2021-10-11

Recruiting

MYTHS - MYocarditis THerapy With Steroids

NCT05150704Myocarditis Acute

DrugMethylprednisolone

Niguarda Hospital

Phase 3

288

Ancona, Bergamo, Bologna, Brescia, Cagliari, Chieti, Florence, Genova

2021-10-07

Active, closed

Efficacy of Robot-assisted Technique vs Conventional Technique in Preventing Early Micromobilisation After UKA

NCT05204797Loosening, Prosthesis

Istituto Ortopedico Rizzoli

Not applicable

Bologna

2021-10-07

Active, closed

A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP

NCT04971226Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive

DrugsBosutinib·Asciminib·ABL001·Nilotinib

Novartis Pharmaceuticals

Phase 3

405

Bologna, Milan, Reggio Emilia, Roma, Verona

2021-10-06

Recruiting

A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments

NCT05020236Multiple Myeloma

DrugsDarzalex·Elranatamab·Pomalidomide·Daratumumab

Pfizer

Phase 3

893

Meldola, Milan, Monza, Catania, Bologna, Genova, Roma

2021-10-04

Recruiting

Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) Patients

NCT06837766Acute on Chronic Liver Failure (ACLF)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Ancona, Bologna, Milan

2021-09-29

Recruiting

Role of the Very Low Calorie Ketogenic Diet (VLCKD) in Patients With Non-Alcoholic Steatohepatitis (NASH) With Fibrosis

NCT06308757NASH, NAFLD, Obesity, Liver Fibrosis

University of Bologna

Not applicable

Bologna

2021-09-29

Active, closed

Study of INBRX-109 in Conventional Chondrosarcoma

NCT04950075Conventional Chondrosarcoma

DrugINBRX-109

Inhibrx Biosciences, Inc

Phase 2

206

Bologna, Candiolo, Milan, Palermo, Prato, Roma

2021-09-23

Active, closed

A Non-interventional Cohort Safety Study of Patients With hATTR-PN

NCT04850105Hereditary Transthyretin Amyloidosis With Polyneuropthy

Akcea Therapeutics

Observational

202

Roma, Bologna, Genova, Messina, Milan, Naples, Pavia

2021-09-21

Recruiting

A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

NCT04557462Primary IgA Nephropathy

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

540

Bologna, Naples

2021-09-20

Active, closed

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

NCT04965493Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsRiabni·Ruxience·Truxima·Pirtobrutinib

Loxo Oncology, Inc.

Phase 3

600

Bologna, Catanzaro, Cona, Cuneo, Florence, Meldola, Milan, Modena

2021-09-20

By invitation

Diagnostic Performance of PET/CT-PSMA in Patients With Non-prostatic PSMA-expressing Neoplasms

NCT06835244PSMA Positive Tumors or Tumor Tissues, Cancer

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,000

Bologna

2021-09-17

Recruiting

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

NCT04973605Relapsed/Refractory Multiple Myeloma

DrugsSonrotoclax·Carfilzomib·Pomalidomide·Daratumumab

BeOne Medicines

Phase 1/2

246

Ancona, Bari, Bologna, Meldola, Milan

2021-09-16

Recruiting

Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma

NCT04305548Mesenchymal Chondrosarcoma

DrugTrabectedin

Italian Sarcoma Group

Phase 2

Prato, Roma, Candiolo, Bologna, Milan, Palermo

2021-09-14

Recruiting

A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies

NCT05006716B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma

DrugTacabrutideg

BeOne Medicines

Phase 1/2

689

Bologna, Milan, Roma, Verona

2021-09-13

Recruiting

Cryopreservation of Ovarian Tissue: Reimplantation Rate and Effects on Ovarian Function

NCT06835088Cryopreservation

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

400

Bologna

2021-09-12

Active, closed

A Study of AL102 in Patients With Progressing Desmoid Tumors

NCT04871282Desmoid, Desmoid Tumor

Immunome, Inc.

Phase 2/3

198

Bologna, Milan, Rome

2021-09-01

Recruiting

The Role of Ultrasonography in Labor in Predicting the Outcomes of Childbirth

NCT06806904Ultrasound in Labor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

116

Bologna

2021-08-31

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)

NCT04961996Early Breast Cancer

DrugGiredestrant

Hoffmann-La Roche

Phase 3

4,170

Avellino, Naples, Bologna, Meldola, Reggio Emilia, Roma, Milan, Rozzano (MI)

2021-08-27

Active, closed

A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )

NCT04849728NASH - Nonalcoholic Steatohepatitis

Inventiva Pharma

Phase 3

1,000

San Giovanni Rotondo, Milan, Naples, Palermo, Roma, Bologna, Novara, Torino

2021-08-19

Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 11 October 2026. https://priyalifescience.com/clinical-trials-italy/city/bologna?page=2

Query this register directly

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,778 studies in total at the last sync on 08 Oct 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,305 of those studies with a site in Bologna.

How many clinical trials are recruiting in Bologna?

808 of the 1,305 studies on this page are recruiting new participants as of the 08 Oct 2026, 03:19 UTC sync. A further 63 have not yet opened recruitment, 420 are active but closed to new participants, and 14 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.