Pharmacological and Mechanical Support Approaches in the Management of Acute Heart Failure in the Regional Network Model for the Management of Cardiogenic Shock

Condition(s) studied

Study summary

The goal of this observational study is to understand and describe the epidemiology of cardiogenic shock in Emilia Romagna with a specific focus on outcome stratified by aetiologies, sex and age. The main outcomes are:

* Incidence of cardiogenic shock (CS) over the total CICU admissions, CS-related in-hospital mortality and length of hospitalization, stratified by aetiologies, sex and age
* Epidemiology of patients admitted with CS, regarding age, gender, etiology and modality of presentation (acute or acute on chronic), echocardiographic and haemodynamic data, treatment strategy with inotropes and/or short-term MCS, cardiac arrest.

This is an observational study without intervention. Patients will be treated according to current clinical practice, according to physician judgment and data sheets of each drug used according to clinical practice.

Eligibility

Primary outcome measure(s)

• Incidence of CS over the total CICU admissions stratified by aetiologies, sex and age. — 5 years
  Incidence
• Length of hospitalization, stratified by aetiologies, sex and age. — 5 years
  Days
• CS-related in-hospital mortality stratified by aetiologies, sex and age. — 5 years
  Incidence
• Epidemiology of patients admitted with CS, regarding age, gender, etiology and modality of presentation (acute or acute on chronic), echocardiographic and haemodynamic data, treatment strategy with inotropes and/or short-term MCS, cardiac arrest. — 5 years
  Demography description
• Recovery from cardiogenic shock, defined as improvement to at least SCAI stage B or discharge from CICU to a step-down ward — 5 years
  Recovery from cardiogenic shock
• In-hospital survival according to age, etiology, presentation (acute or acute on chronic) and modality of treatment (inotropes or MCS). — 5 years
  In-hospital survival
• Rate and reason of unplanned re-hospitalizations within one month after primary discharge — 5 years
  Rate and reason of unplanned re-hospitalizations
• Workload burden will be estimated as the percentage of CS admission and the mean duration of CICU stay as compared to other admissions during study period — 5 years
  Workload burden
• Rate of adherence to several items and differences between older era (retrospective data) and prospective cohort — 5 years
  Blood counts, ECG, oxygen saturation and respiratory monitoring.

Trial sites (1)

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