Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)
Condition(s) studied
Investigational drug(s) / intervention(s)
Durvalumab: Participants that go on to receive surgery, will receive durvalumab for up to four cycles prior to surgery. Participants that go on to receive CRT will receive durvalumab for up to two cycles prior to CRT. All participants will receive durvalumab every four weeks until disease progression or recurrence or up to 12 months following surgery/CRT, unless there is unacceptable toxicity, withdrawal of consent, or another discontinuation criterion is met.
Study summary
The purpose of this study is to assess efficacy and safety of neoadjuvant durvalumab in combination with platinum-based chemotherapy (CT) given as initial therapy after cancer diagnosis followed by either surgery and adjuvant durvalumab or chemoradiotherapy (CRT) and consolidation durvalumab given alone as further therapy in participants with resectable and borderline resectable stage IIB-IIIB NSCLC.
Eligibility
Primary outcome measure(s)
- Resection rate — At day of surgery (Within 40 days of the last dose of neoadjuvant treatment)
Resection rate is defined as the proportion of all participants who underwent definitive surgery. Participants who undergo (ie, start) surgery with the goal of complete tumour resection will be counted as meeting this endpoint.
Trial sites (49)
| Facility | City | Region | Status |
|---|---|---|---|
| Research Site | The Bronx | New York | |
| Research Site | Houston | Texas | |
| Research Site | Charlottesville | Virginia | |
| Research Site | Vienna | Austria | |
| Research Site | Vienna | Austria | |
| Research Site | Kingston | Ontario | |
| Research Site | Chicoutimi | Quebec | |
| Research Site | Montreal | Quebec | |
| Research Site | Brno | Czechia | |
| Research Site | Olomouc | Czechia | |
| Research Site | Prague | Czechia | |
| Research Site | Prague | Czechia | |
| Research Site | La Tronche | France | |
| Research Site | Marseille | France | |
| Research Site | Montpellier | France | |
| Research Site | Mulhouse | France | |
| Research Site | Paris | France | |
| Research Site | Pessac | France | |
| Research Site | Poitiers | France | |
| Research Site | Toulouse | France | |
| Research Site | Berlin | Germany | |
| Research Site | Cologne | Germany | |
| Research Site | Großhansdorf | Germany | |
| Research Site | Moers | Germany | |
| Research Site | Würzburg | Germany | |
| Research Site | Budapest | Hungary | |
| Research Site | Törökbálint | Hungary | |
| Research Site | Bari | Italy | |
| Research Site | Bologna | Italy | |
| Research Site | Milan | Italy | |
| Research Site | Milan | Italy | |
| Research Site | Milan | Italy | |
| Research Site | Naples | Italy | |
| Research Site | Palermo | Italy | |
| Research Site | Pavia | Italy | |
| Research Site | Peschiera del Garda | Italy | |
| Research Site | Lisbon | Portugal | |
| Research Site | Lisbon | Portugal | |
| Research Site | Barakaldo | Spain | |
| Research Site | Barcelona | Spain |
+ 9 more sites — see the full list on the official registry below.
On this site
📄 Imfinzi (durvalumab) drug profile →More AstraZeneca trials in Italy
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05925530 on ClinicalTrials.gov ↗ ← All trials in Italy