Clinical trial register · France

Clinical Trials in Rouen, 2026

Every study on the ClinicalTrials.gov registry that lists a site in France and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 9697 matching records held by the registry are in this view. Synced 26 Oct 2026, 03:20 UTC

9697

Studies in scope

all four open statuses

6025

Recruiting now

open to new participants

1033

Lead sponsors

across recruiting studies

Top sites

Paris 2821 Lyon 1392 Bordeaux 1389 Marseille 1285 Lille 1282

Trials with a site in Rouen

Status

Study

Lead sponsor

Phase

Enrol

Sites in France

Start

Not yet open

Ticagrelor Hemoadsorption Using Cytosorb® for Reduction of Bleeding During Cardiac Surgery

NCT07822620Cardiac Surgery

University Hospital, Rouen

Not applicable

232

Rouen

2026-11

Not yet open

Evaluation of the Efficacy and Safety of Bimekizumab (BZK) or Adalimumab (ADA) in the Treatment of Anterior Chest Wall Pain Associated With Active Axial Spondyloarthritis Refractory to NSAIDs With Hypothesis of Superiority of Bimekizumab

NCT07836283Axial or Predominantly Axial SpondyloArthritis With or Without Psoriasis

DrugsBimekizumab·Adalimumab

University Hospital, Rouen

Phase 3

150

Rouen

2026-10-15

Not yet open

Impact of Probiotics on Neuropathy Induced by Adjuvant Chemotherapy in Patients With Colon Cancer.

NCT07733817Colon Adenocarcinoma, Neuropathic Pain

Centre Francois Baclesse

Not applicable

130

Caen, Bayeux, Lille, Rouen, Saint-Lô

2026-10-01

Recruiting

Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm in Chronic Lung Diseases

NCT07597187Interstitial Lung Diseases (ILD), Pulmonary Emphysema, Chronic Lung Diseases, Occupational Lung Diseases

University Hospital, Grenoble

Observational

Grenoble, Nancy, Rouen

2026-10-01

Not yet open

Effect of Intestinal Carriage of *Pilosibacter Rotomagensis* on Intestinal Inflammatory Activity

NCT07871383Crohn's Diseases

University Hospital, Rouen

Observational

116

Rouen

2026-10-01

Not yet open

Quality of Recovery at Days 5-7 After Ankle Surgery: a Multicenter Study in Seine-Maritime

NCT07814937Ankle Surgery

University Hospital, Rouen

Observational

260

Dieppe, Elbeuf, Le Havre, Rouen

2026-10-01

Recruiting

Upadacitinib in Adult Patients With Erosive Mucosal Lichen Planus and Lichen Planopilaris: a Prospective Multicenter Randomized Placebo-controlled Study.

NCT07492251Lichen Penis Planus

DrugUpadacitinib

Centre Hospitalier Universitaire de Nice

Phase 2

Nice, Paris, Reims, Rouen, Tours

2026-10-01

Not yet open

Immunomonitoring and Predictive Biomarkers After CAR-T Cell Therapy in B-Cell Lymphoma and Multiple Myeloma

NCT07852377B Cell Lymphoma, Multiple Mieloma

Centre Henri Becquerel

Not applicable

Rouen

2026-09-18

Not yet open

Contribution of the VERITON-CT Camera in Prostate Bone Radiostereotaxy

NCT06439784Prostatic Cancer

Centre Henri Becquerel

Not applicable

Rouen

2026-09-15

Recruiting

Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies

NCT07648264Secondary Immune Deficiency

DrugHizentra

CSL Behring

Phase 3

Rennes, Nantes, Angers, La Roche-sur-Yon, Rouen

2026-09-15

Not yet open

Precarity and Reduction of Its Impact on the Mental Health of Health Students

NCT07539207Mental Health (Depression), Mental Health, Quality of Lifte

Institut National de la Santé Et de la Recherche Médicale, France

Not applicable

110

Rouen

2026-09-15

Recruiting

Dermocosmetic Treatment for Facial Redness in Rosacea With or Without Laser Therapy

NCT07521462Rosacea, Erythematotelangiectatic, Rosacea Subtype 1 (Erythematotelangiectatic)

ISISPHARMA

Not applicable

Rouen

2026-09-03

Not yet open

Time Course of Respiratory Oscillometry Parameters During Nasal High-Flow Therapy in Stable Chronic Obstructive Pulmonary Disease

NCT07750613Chronic Obstructive Pulmonary Disease (COPD)

ADIR Association

Not applicable

Rouen

2026-09-01

Not yet open

Impact of Prophylactic Bone Radiation Therapy in Patients With Bone Metastases.

NCT07733193Bone Metastases

Centre Henri Becquerel

Phase 3

154

Nancy, Rouen

2026-09-01

Not yet open

Evaluation of the Efficacy of Ischemic Preconditioning to Protect Against Acute Kidney Injury After Open Surgery for Juxtarenal Abdominal Aortic Aneurysm

NCT07441564Aneurysm Aortic

University Hospital, Rouen

Not applicable

206

Dijon, Lille, Nancy, Nantes, Paris, Rouen, Toulouse

2026-09-01

Not yet open

Factors Associated With Acceptance of Home-Based Pulmonary Telerehabilitation in COPD

NCT07747571Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Rehabilitation

ADIR Association

Observational

Rouen

2026-09-01

Not yet open

Impact of Body Composition on Dosimetry of 177Lu-PSMA Radioligand Therapy

NCT07587814Carcinoma, Castration Resistant Prostatic Neoplasms

Centre Henri Becquerel

Not applicable

100

Rouen

2026-09

Not yet open

SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer

NCT07241273Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Cancers, Oropharyngeal Carcinoma, Head and Neck

UNICANCER

Not applicable

128

Brest, Caen, Dijon, Le Havre, Lille, Montpellier, Paris, Rouen

2026-09

Not yet open

Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease

NCT07498309Vaso-Occlusive Crises, Sickle Cell Disease

DrugIloprost

University Hospital, Rouen

Phase 3

144

Rouen

2026-09

Recruiting

IMpact of Mind-body Therapies (HYpnosis and Relaxation) on Anxiety in Children, Adolescents and Young Adults Who Had Been Treated in ONcology. Multicenter Study.

NCT07380672Adolescent Cancer Survivors, Childhood Cancer Survivors, Anxiety

Centre Hospitalier Universitaire de Saint Etienne

Not applicable

558

Caen, Grenoble, Lyon, Rouen, Saint-Etienne

2026-08-04

Recruiting

Feasibility Study on the Implementation of a Supervised, Home-based Adapted Physical Activity Program for Patients With Head and Neck Cancer

NCT07560397Head & Neck Cancer

Centre Henri Becquerel

Not applicable

Rouen

2026-07-22

Recruiting

Evaluation of [68Ga]Ga-NOTA-anti-HER2-sdAb PET/CT for Predicting Pathological Complete Response After Neoadjuvant Chemotherapy in HER2 Positive Early Breast Cancer

NCT07593976Breast Cancer

Centre Henri Becquerel

Phase 2

Rouen

2026-07-15

Recruiting

Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease

NCT07274254Vaso-Occlusive Pain Episode in Sickle Cell Disease

DrugLidocain

Nantes University Hospital

Phase 3

104

Bordeaux, Lille, Marseille, Nantes, Orléans, Paris, Poitiers, Rouen

2026-07-03

Not yet open

Screening for Subclinical Antibody Mediated Rejection and Efficacy of Belatacept in the Context of de Novo Donor Specific Antibody After Kidney Transplantation (BELA-M-R)

NCT06291103Kidney Transplant Rejection

University Hospital, Rouen

Phase 2/3

290

Rouen

2026-07-01

Not yet open

Impact of Reventilation After One-Lung Ventilation in Thoracic Surgery (OLVREEXP)

NCT07247500Lung Surgery

University Hospital, Rouen

Not applicable

350

Amiens, Lille, Rouen, Suresnes

2026-07-01

Not yet open

Functional Residual Capacity and Alveolar Recruitment in Single-lung Ventilation: a Randomized Study

NCT06446544Lung Injury

University Hospital, Rouen

Not applicable

Rouen

2026-07-01

Not yet open

Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE)

NCT07132164Polymyalgia Rheumatica, Inflammatory Rheumatism

University Hospital, Brest

Observational

400

Rouen, Besançon, Bordeaux, Boulogne-sur-Mer, Brest, Caen, Caluire-et-Cuire, Clermont-Ferrand

2026-07-01

Not yet open

Oral Microbiota and Muscle Function in the Ageing Subject

NCT07687511Non-hospitalised Men and Women Over 70 Years of Age

University Hospital, Rouen

Not applicable

Rouen

2026-07

Not yet open

Efficacy and Tolerance of Baricitinib, a JAK Inhibitor, in the Treatment of Refractory Non-infectious Non-anterior Uveitis

NCT05651880Active Non-anterior Non-infectious Uveitis

DrugBaricitinib

University Hospital, Rouen

Phase 3

Rouen

2026-07

Not yet open

AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation

NCT07604727Atrial Fibrillation (AF), Heart Failure, Cardiac Pacing

University Medical Center Groningen

Not applicable

292

Grenoble, Marseille, Paris, Rouen, Toulouse

2026-07

Not yet open

Postoperative Anti-infective Strategy Following Pancreaticoduodenectomy in Patients With Preoperative Biliary Stent

NCT06123169Pancreaticoduodenectomy, Antibiotherapy

DrugPiperacillin-tazobactam

University Hospital, Rouen

Phase 3

326

Rouen

2026-07

Recruiting

Safety and Performances of the LINEA Cardiac Pacing Lead Optimized for the Implantation in Interventricular Septum

NCT07342608Bradycardia, Left Bundle Branch Area Pacing, Left Bundle Branch Pacing

MicroPort CRM

Not applicable

450

Annecy, Clermont-Ferrand, Grenoble, Montpellier, Rouen, Tours

2026-06-23

Recruiting

An Evaluation of Multisense® to Ensure a Safe Return Home Following High-risk Gastrointestinal Surgery, Compared With Standard Care.

NCT07552805Reduction in the Initial Length of Stay

Rhythm Diagnostic Systems

Not applicable

490

Nice, Saint-Etienne, Rennes, Besançon, Reims, Bourgoin, Rouen, Amiens

2026-06-16

Recruiting

Phase IIa Trial of Anti-CD19 CAR T-Cells in Systemic Sclerosis Resistant to Immunosuppressive Therapy

NCT07493395Scleroderma, Systemic

University Hospital, Montpellier

Phase 2

Lille, Montpellier, Paris, Rouen

2026-06-11

Not yet open

Prospective Exploration of Vascular Complications Associated With the Use of Immune Checkpoint Inhibitors

NCT07535944Vascular Complications

University Hospital, Rouen

Observational

200

Rouen

2026-06-01

Not yet open

Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension

NCT07464184Precapillary Pulmonary Hypertension, Pulmonary Arterial Hypertension, Sleep-disordered Breathing, Nocturnal Hypoxemia

University Hospital, Rouen

Not applicable

Rouen

2026-06-01

Not yet open

Prediction of Postoperative Pulmonary Complications in Thoracic Surgery

NCT07359885Postoperative Pulmonary Complications (PPCs)

University Hospital, Rouen

Observational

100

Rouen

2026-06-01

Not yet open

Megarectum in Adults

NCT07599527Idiopathic Megarectum

University Hospital, Rouen

Observational

120

Rouen

2026-06-01

Not yet open

De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer

NCT06446557Metastatic Colon Cancer

University Hospital, Rouen

Phase 3

408

Rouen

2026-06

Not yet open

Valvosoft Outcomes Registry for Real-World Evidence

NCT07520591Aortic Valve Disease, Aortic Stenosis, Severe, Aortic Valve Calcification, Ultrasound Therapy

Cardiawave SA

Observational

200

Paris, Rouen

2026-05-30

Recruiting

Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy

NCT07539012Fuchs Endothelial Corneal Dystrophy

Centre Hospitalier Universitaire de Saint Etienne

Not applicable

Saint-Etienne, Metz, Paris, Rouen

2026-05-21

Recruiting

Safety of RotigotiNe in Patients With Autosomal Dominant Polycystic Kidney Disease

NCT06291116Kidney Diseases

University Hospital, Rouen

Phase 2

120

Amiens, Caen, Lille, Rouen

2026-05-12

Recruiting

Comparison of the Effects of Belatacept and Anticalcineurins on Endothelial Function in Renal Transplant Patients - <BELAFENDO>

NCT06291077Kidney Diseases

DrugBelatacept

University Hospital, Rouen

Phase 4

Rouen

2026-04-30

Recruiting

Remibrutinib Open Label Roll-over Post-trial Access Protocol

NCT07456891Indication of the Parent Protocol

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

650

Bordeaux, Brest, Montpellier, Paris, Pierre-Bénite, Rouen

2026-04-16

Recruiting

RATS Sleeve Lobectomy After Neo-Chemo-IO for NSCLC

NCT07541521Stage IIB-III NSCLC, Sleeve Lobectomy, Robotic Surgery, Neoadjuvant Chemoimmunotherapy

Shanghai Chest Hospital

Observational

100

Marseille, Rouen

2026-04-13

Not yet open

Pharmacokinetic Study of the Use of Nefopam 30 mg Tablets in Patients Suffering From Acute Pain in Rheumatology

NCT07491393Acute Rheumatic Pain

University Hospital, Rouen

Phase 4

Rouen

2026-04-01

Recruiting

Benefits of Formalized Care Support Program Following Acute Leukemia Diagnosis

NCT07499765Acute Leukemia

Centre Henri Becquerel

Not applicable

110

Rouen

2026-03-30

Recruiting

A Phase IIb Dose-ranging Study to Assess the Efficacy and Safety of GIA632 in Participants With Non-segmental Vitiligo

NCT07431177Non-segmental Vitiligo

DrugGIA632

Novartis Pharmaceuticals

Phase 2

210

Bordeaux, Brest, Créteil, Nice, Reims, Rouen, Toulouse

2026-03-09

Recruiting

A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NCT07218341Chronic Lymphocytic Leukemia, Lymphoma, Small Lymphocytic

DrugsIdelalisib·Pirtobrutinib

Eli Lilly and Company

Phase 4

150

Rouen

2026-03-09

Recruiting

Benefit of Sleep Quality Monitoring by EEG in ICU

NCT07522450Respiratory Failure

University Hospital, Rouen

Observational

Rouen

2026-03-04

Recruiting

Downstaging and RATS After Neo-Chemo-IO: Impact on Surgical Outcomes in NSCLC

NCT07528066Neoadjuvant Chemoimmunotherapy, Robotic Pulmonary Resection, Stage IIB-III NSCLC

Shanghai Chest Hospital

Observational

200

Marseille, Rouen

2026-03-02

Not yet open

Efficacy of Domperidone (a Prokinetic Agent) on Time in Range in Digestively Asymptomatic Type I Diabetic Patients With Delayed Gastric Emptying (Gastro-TIR)

NCT06695962Type 1 Diabetic

DrugDomperidone

University Hospital, Rouen

Phase 3

Amiens, Caen, Dieppe, Elbeuf, Le Havre, Rouen

2026-03-01

Not yet open

Pharmacometric Modeling of a Hospital Preparation

NCT07372560Hypertensive Patients

University Hospital, Rouen

Observational

Rouen

2026-03-01

Not yet open

PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants

NCT07411261Bronchopulmonary Dysplasia, Preterm Infant Development, Asthma Childhood, Bronchiolitis

DrugsStool sampling·Blood sampling

University Hospital, Caen

Not applicable

270

Amiens, Caen, Cherbourg, Le Havre, Lille, Rouen

2026-03

Not yet open

Using the Accuvein Device for Patients Who Are Difficult to Perfuse

NCT06861595Patient Who Are Difficult to Infuse

University Hospital, Rouen

Not applicable

100

Rouen

2026-03

Not yet open

Benefits of Early Proprioceptive Re-education Without Visual Information After Total Knee Arthroplasty

NCT06936267Unilateral Primary Osteoarthritis, Left Knee

University Hospital, Rouen

Not applicable

Bois-Guillaume, Rouen

2026-03

Recruiting

Evaluation of Gynecological and Sexual Sequelae

NCT07389863Rectal Cancer Patients

University Hospital, Rouen

Observational

Rouen

2026-02-09

Not yet open

New Microbiota-endocrine Axis in Fructose Malabsorption-caused Visceral Hypersensitivity in Irritable Bowel Syndrome.

NCT07337707Irritable Bowel Syndrome (IBS)

DrugBlood test

University Hospital, Rouen

Not applicable

Rouen

2026-02

Recruiting

A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

NCT07219212Squamous Cell Carcinoma of Head and Neck

DrugsJNJ-90301900·Paclitaxel·Cisplatin·Carboplatin

Johnson & Johnson Enterprise Innovation Inc.

Phase 1

Brest, La Tronche, Lille, Marseille, Rouen, Villejuif

2026-01-26

Recruiting

A Study of Zasocitinib in Adults With Hidradenitis Suppurativa

NCT07244263Hidradenitis Suppurativa

DrugZasocitinib

Takeda

Phase 2

Nice, Marseille, Martigues, Lyon, Le Mans, Rouen

2026-01-26

Not yet open

Evaluation of the Clinical Utility of Online Adaptive Radiotherapy in Bladder Cancer (BLADAPT-GETUG V11)

NCT07043543Bladder Cancer

Institut du Cancer de Montpellier - Val d'Aurelle

Not applicable

120

Dijon, Montpellier, Rennes, Saint-Herblain, Lille, Villeurbanne, Rouen, Avignon

2026-01-15

By invitation

SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study

NCT07116668Colorectal Cancer, Stoma - Ileostomy

SafeHeal Inc

Not applicable

108

Bourdeaux, Rouen, Paris

2026-01-08

By invitation

Lead Evaluation for Defibrillation and Reliability Post Approval Study

NCT07005232Tachyarrhythmia

Medtronic

Observational

2,000

Chambray-lès-Tours, La Tronche, Lille, Montpellier, Pessac, Rennes, Rouen, Toulouse

2026-01-07

Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

NCT07221357Untreated, Unresectable, or Metastatic Colorectal Cancer

DrugsPumitamig·Folfox·Bevacizumab

Bristol-Myers Squibb

Phase 2/3

990

Pessac, Besançon, Toulouse, Rouen, Suresnes, Saint-Herblain, Lorient, Lille

2025-12-31

Not yet open

Early Identification of Children With Asthma

NCT06988358Asthma in Children

University Hospital, Rouen

Observational

300

Le Grand-Quevilly, Rouen, Val-de-Reuil

2025-12-30

Recruiting

A Study to Investigate Efficacy and Safety With SAR445399 in Adult Participants With Moderate to Severe Hidradenitis Suppurativa

NCT07225569Hidradenitis Suppurativa

Sanofi

Phase 2

144

Lille, Nantes, Paris, Rouen

2025-12-29

Recruiting

Risk-adapted Adjuvant Chemotherapy Guided by the Tumour Stage for Operated Pancreatic Adenocarcinoma Following Neoadjuvant Chemotherapy With mFOLFIRINOX

NCT07044453Resected Pancreatic Adenocarcinoma

DrugMFOLFIRINOX

University Hospital, Rouen

Phase 2/3

390

Rouen

2025-12-08

Recruiting

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

NCT07276399Squamous Cell Carcinoma of Head and Neck

DrugsAmivantamab·Cisplatin·Carboplatin·Pembrolizumab

Janssen Research & Development, LLC

Phase 3

500

Avignon, Le Mans, Lille, Marseille, Paris, Rouen, Saint-Herblain, Villejuif

2025-12-03

Not yet open

Multimodal Prediction of Response to Chemoradiotherapy for Squamous Cell Carcinoma of the Head and Neck

NCT07259915Squamous Cell Cancer of Head and Neck (SCCHN)

Centre Henri Becquerel

Not applicable

152

Rouen

2025-12-01

Recruiting

Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation

NCT07211958Acute Myeloid Leukemias

DrugRevumenib

Syndax Pharmaceuticals

Phase 3

468

Nice, Strasbourg, Marseille, Caen, Rouen, Limoges, Angers, Lille

2025-11-25

Recruiting

Trial Evaluating the Benefit of Left Bundle Branch Area Stimulation Compared With Conventional Pacing in Post-TAVI Atrioventricular Atrioventricular Block

NCT07236489Atrioventricular Block, Pacemaker

Nantes University Hospital

Not applicable

266

Brest, Rennes, Tours, Nantes, Clermont-Ferrand, Rouen, Poitiers

2025-11-25

Recruiting

A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema

NCT07216027Atopic Dermatitis, Eczema, Atopic

Pfizer

Phase 2

165

Paris, Rouen, Toulouse

2025-11-20

Recruiting

Fluid-responsiveness in Children Ventilated With LOW Tidal Volume - The FLOW Study.

NCT07494643Circulatory Failure (Shock)

University Hospital, Bordeaux

Not applicable

Amiens, Bordeaux, Limoges, Paris, Rouen

2025-11-10

Recruiting

Performance of 18F-FDG Micro-PET-CT in the Assessment of Surgical Margins in Head and Neck Cancer

NCT07285564Head & Neck Cancer

Centre Henri Becquerel

Not applicable

Rouen

2025-11-07

Recruiting

Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Transverse Orthodontic Deficiency in Children

NCT07086612Obstructive Sleep Apnea, Transverse Maxillary Deficiency

Fondation Hôpital Saint-Joseph

Not applicable

102

Rouen

2025-11-06

Recruiting

Treated Umbilical Vein Allograft (UVT) Versus Autologous Fascial Pubovaginal Sling in the Treatment of Female Stress Urinary Incontinence

NCT06678984Stress Urinary Incontinence in Women

TBF Genie Tissulaire

Phase 3

Clermont-Ferrand, La Tronche, Nantes, Paris, Pierre-Bénite, Rouen, Strasbourg, Toulouse

2025-11-06

Recruiting

A Randomized, Parallel-arm, Double Blind, Placebo-controlled Study to Assess the Efficacy of Fampridine for Patients With Spinocerebellar Ataxia SCA27B Caused by a GAA Expansion in the FGF14 Gene

NCT07185347Spinocerebellar Ataxia 27B (SCA27B)

DrugFampridine

Assistance Publique - Hôpitaux de Paris

Phase 3

Angers, Bordeaux, Dijon, Lyon, Montpellier, Paris, Rouen, Strasbourg

2025-10-21

Recruiting

Impact of Patient-Reported Outcomes for Symptom Monitoring in Patients Followed for Head and Neck Squamous Cell Carcinoma (HNSCC)

NCT07190755Head and Neck Squamous Cell Carcinoma HNSCC

Centre Henri Becquerel

Not applicable

192

Rouen, Vandœuvre-lès-Nancy

2025-10-15

Recruiting

Determine the Frequency of Variants in the GBA/PSAP Genes in Patients With MM or MGUS

NCT06559033Monoclonal Gammopathy of Undetermined Significance, Myeloma Multiple

University Hospital, Rouen

Observational

300

Rouen

2025-10-07

Not yet open

Evaluation of the Dialytic Clearance of the Combination of Peracillin and Tazobactam

NCT07167524Sepsis, Severe Bacterial Infections

University Hospital, Rouen

Observational

Rouen

2025-10-01

Not yet open

In Situ Injection of Anti-angiogenics in Patients With Brain Arteriovenous Malformations Not Eligible for Exclusion Treatment

NCT07075757Brain Arteriovenous Malformations

Assistance Publique - Hôpitaux de Paris

Phase 1

Limoges, Nancy, Paris, Rouen

2025-10-01

Recruiting

Impact of Early, Personalized Nutritional Management on 1-month Mortality After Acute Stroke

NCT07065929Acute Stroke

University Hospital, Angers

Not applicable

3,084

Chesnay, Angers, Caen, Cholet, La Roche-sur-Yon, La Rochelle, Le Coudray, Rouen

2025-09-19

Recruiting

Evaluate the Benefit of Corticoid Sparing in Elderly With Generalized AntiRAch Myasthenia Gravis Treated With IV or SC Efgartigimod

NCT07072988Myasthenia Gravis, Generalized

DrugEfgartigimod

Centre Hospitalier Universitaire de Nice

Phase 4

Nice, Créteil, Garches, Grenoble, Lille, Marseille, Nancy, Rouen

2025-09-19

Recruiting

Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach

NCT05969457Hysterotomy; Affecting Fetus

University Hospital, Rouen

Phase 3

108

Le Havre, Rouen

2025-09-16

Recruiting

European Real-World Registry for Use of the Ion Endoluminal System

NCT06923774Pulmonary Nodule, Lung Cancer

Intuitive Surgical

Observational

1,200

Brest, Le Plessis-Robinson, Rouen

2025-09-09

Recruiting

A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06973187Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsTacabrutideg·Pirtobrutinib

BeOne Medicines

Phase 3

500

Bordeaux, ClermontFerrand, Nantes, Paris, Rouen, Toulouse, Tours, VandoeuvrelesNancy

2025-09-04

Recruiting

Biomedical Innovation for Facial Bone Reconstruction in Oncology: BIOFACE PASS a Medico-economic Study Describing the Standard Pathway of Patients Treated by Free Bone Flap

NCT06771336Head and Neck Cancers

University Hospital, Toulouse

Observational

200

Amiens, Lille, Lyon, Montpellier, Nantes, Nice, Rouen, Toulouse

2025-09-03

Recruiting

Ustekinumab in BEhçet's Syndrome STudy

NCT07244614Behçet's Syndrome (BS)

Groupe français d'étude des Maladies Inflammatoires de loeil

Observational

208

Bordeaux, Créteil, Lyon, Melun, Paris, Rouen

2025-09-01

Not yet open

Liquid Biopsies for Detecting Somatic Mutations in Sporadic Cerebral Arteriovenous Malformations.

NCT07103304Cerebral Arteriovenous Malformations

University Hospital, Rouen

Observational

Caen, Paris, Rouen

2025-09-01

Active, closed

Retrospective Evaluation of the Implementation of a Digital Solution Supporting the Delivery of Pulmonary Rehabilitation Programs in Private Physiotherapy Practice

NCT07687836Chronic Obstructive Pulmonary Disease (COPD), Respiration Disorders, Pulmonary Rehabilitation, Chronic Respiratory Diseases

ADIR Association

Observational

Rouen

2025-09-01

Not yet open

Impact of Comprehensive Geriatric Management on Morbidity and Quality of Life in Elderly Patients Undergoing Major Hepatectomy and Pancreaticoduodenectomy for Cancer

NCT06999512Hepatobiliary Cancer, Pancreatic Cancer

Assistance Publique - Hôpitaux de Paris

Phase 2/3

526

Clermont-Ferrand, Le Kremlin-Bicêtre, Lille, Lyon, Marseille, Paris, Rouen, Toulouse

2025-09

Not yet open

Prospective Cohort of Patients Treated Using Neoadjuvant Modified FOLFIRINOX 6 Cycles for Potentially Resectable Pancreatic Duct Adenocarcinoma, Candidate for Participation in the PANACHE02 Clinical Trial

NCT07034703Resectable Pancreatic Duct Adenocarcinoma

University Hospital, Rouen

Observational

820

Rouen

2025-09

Not yet open

Low Powered Colorectal Anastomosis After Rectal Excision (OASIS)

NCT07146334Rectal Cancer, Surgery Indication

Bordeaux Colorectal Institute

Observational

400

Besançon, Bordeaux, Le Kremlin-Bicêtre, Lyon, Paris, Rouen

2025-09

Not yet open

Evaluation of the Superficial Cervical Plexus Block in Oncological Throat and Neck Surgery

NCT07110857ENT Cancers

Assistance Publique - Hôpitaux de Paris

Not applicable

346

Lille, Marseille, Paris, Rouen, Suresnes, Villejuif

2025-09

Recruiting

Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List

NCT06868797Heart Failure

Central Hospital, Nancy, France

Not applicable

103

Bron, La Tronche, Montpellier, Nantes, Paris, Pessac, Rennes, Rouen

2025-08-29

Recruiting

Telerehabilitation Versus Centre-based Pulmonary Rehabilitaztion for Patients With Chronic Obstructive Pulmonary Disease

NCT07025382Chronic Obstructive Pulmonary Disease (COPD)

ADIR Association

Not applicable

Montivilliers, Morlaix, Rouen, Saint-Sébastien-de-Morsent

2025-08-14

Recruiting

Evaluation of the Safety of Electrical Spinal Cord Stimulation in Parkinson's Patients Presenting With Painful Camptocormia

NCT06291051Parkinson Disease

University Hospital, Rouen

Not applicable

Amiens, Caen, Lille, Rouen

2025-08-01

Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

NCT07060807Breast Neoplasms

DrugsPatritumab deruxtecan·Pegylated liposomal doxorubicin·Abraxane·Xeloda

Merck Sharp & Dohme LLC

Phase 3

1,000

Brest, Lyon, Rouen, Villejuif

2025-07-21

Recruiting

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

NCT06997497Colon Adenocarcinoma, Rectal Adenocarcinoma

DrugsLeucovorin/levofolinate calcium·Bevacizumab biosimilar·Calderasib·Mvasi

Merck Sharp & Dohme LLC

Phase 3

477

Nice, Caen, Toulouse, Limoges, Vandœuvre-lès-Nancy, Reims, Angers, Rouen

2025-07-16

Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

NCT06976216Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

586

Nice, Toulouse, Rouen, Montpellier, Reims, Villeurbanne, Dijon

2025-07-14

Recruiting

Impact of Ehlers-Danlos Syndrome on Gynaecological Health

NCT07151274Ehlers-Danlos Syndrome (EDS)

University Hospital, Rouen

Observational

156

Rouen

2025-07-07

Recruiting

Spinal Palliation in Irradiation for Neoplastic Analgesia and Life Quality

NCT06884332Bone Metastasis, Oncology Pain

Institut de Cancérologie de Lorraine

Not applicable

598

Brest, Rouen, Saint-Herblain, Vandœuvre-lès-Nancy

2025-07-02

Not yet open

Pharmacokinetic Modelling of Levosimendan in Adults

NCT06993584Cardiogenic Shock

University Hospital, Rouen

Observational

100

Amiens, Lille, Rouen

2025-07-01

Not yet open

Feasibility of ORGAnoids in Routine Clinical Practice for Molecular Analysis of the GLIOvascular Niche in Patients With Primary Brain Tumors.

NCT07029100Glioblastoma

Centre Henri Becquerel

Not applicable

Le Havre, Rouen

2025-07-01

Recruiting

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099Crohn's Disease, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

290

Échirolles, La Roche-sur-Yon, Le Kremlin-Bicêtre, Montpellier, Neuilly-sur-Seine, Nice, Paris, Rouen

2025-06-26

Recruiting

Chronic Nausea and Vomiting in Patients With Normal Gastric Emptying Using the Enterra® Therapy System (NAVIGATE)

NCT06464926Nausea, Vomiting

Enterra Medical, Inc.

Not applicable

148

Colombes, Lyon, Pessac, Rouen

2025-06-23

Active, closed

Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)

NCT06958211Hidradenitis Suppurativa

DrugRuxolitinib

Incyte Corporation

Phase 3

573

Reims, Rouen, Saint-Etienne, Toulouse

2025-06-12

Recruiting

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

NCT06943872Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsSonrotoclax·Venclexta·Obinutuzumab·Venetoclax

BeOne Medicines

Phase 3

630

ClermontFerrand, Nantes, Paris, PierreBenite, Reims, Rennes Cedes, Rouen, Toulouse

2025-06-11

Recruiting

Effectiveness of the RAUC Pathway in Reducing Unscheduled Hospitalizations After Emergency Digestive Surgery

NCT06769438Digestive Emergency, New Pathway, Connected Health

Centre Hospitalier Universitaire, Amiens

Not applicable

3,000

Rouen, Salouël

2025-06-02

Recruiting

Intermittent Intrapulmonary Deflation and Dyspnea Following Exercise in People With Chronic Obstructive Pulmonary Disease

NCT06956742Chronic Obstructive Pulmonary Disease (COPD)

ADIR Association

Not applicable

Rouen

2025-06-01

Recruiting

Hybrid Prehabilitation Before Thoracic Surgery

NCT06866717Non-Small Cell Lung Cancer

ADIR Association

Not applicable

Rouen

2025-05-30

Recruiting

Radiological Prediction of Response to Neoadjuvant Chemoimmunotherapy for Triple-negative Breast Cancer

NCT06879704Triple Negative Breast Cancer

Centre Henri Becquerel

Not applicable

115

Rouen

2025-05-28

Recruiting

Efficacy of an Adapted Antibiotherapy in Hurley Stage 2 Hidradenitis Suppurativa Patients

NCT05821478Hidradenitis Suppurativa

Institut Pasteur

Phase 3

Marseille, Paris, Rouen

2025-05-22

Active, closed

Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa

NCT06940830Hemophilia A

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 4

252

Bordeaux, Marseille, Montpellier, Nantes, Paris, Rennes, Rouen

2025-05-21

Active, closed

A Study to Assess the Safety and Effectiveness of the UrOActive® Artificial Urinary sPHincter (AUS)

NCT06968741Stress Urinary Incontinence (SUI)

UroMems SAS

Not applicable

140

Lille, Marseille, Nantes, Paris, Pierre-Bénite, Rennes, Rouen, Suresnes

2025-05-19

Recruiting

A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

NCT06522737Lymphoma

DrugsDuvelisib·Bendamustine·Gemcitabine

SecuraBio

Phase 3

124

Rouen, Villejuif, Caen, Clermont-Ferrand, Montpellier, Nantes, Paris, Pessac

2025-05-19

Recruiting

Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis

NCT06947993Atopic Dermatitis

Novartis Pharmaceuticals

Phase 2

224

Brest, Lille, Lorient, Paris, Pierre-Bénite, Reims, Rouen

2025-05-16

Recruiting

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

NCT06990867Acute Ischemic Stroke

Corxel Pharmaceuticals

Phase 2/3

740

Lille, Nancy, Paris, Rouen, Toulouse, Tours

2025-05-15

Recruiting

The Impact of Paramedic Training in Simulation on the Experience of Patients Treated for Malignant Brain Tumors in Neurosurgery (IPSIMANON)

NCT06962215Brain Tumor Adult

University Hospital, Brest

Not applicable

250

Brest, Amiens, Angers, Bordeaux, Marseille, Nantes, Nice, Rouen

2025-05-15

Recruiting

Surgical vs Transcatheter Aortic Valve Replacement in YOUNG Patients

NCT06861361Symptomatic Severe Aortic Stenosis

Ceric Sàrl

Not applicable

1,180

Lille, Lyon, Massy, Rouen, Toulouse

2025-05-15

Recruiting

Long Read Analysis in Spinal Muscular Atrophy - LOREASI

NCT07332702Spinal Muscular Atrophy (SMA)

University Hospital, Rouen

Not applicable

Rouen

2025-05-15

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

NCT06925750Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

130

Pessac, Marseille, Rouen, Clermont-Ferrand

2025-05-12

Recruiting

Benefit of Transcutaneous Auricular Vagus Nerve Stimulation in Improving Quality of Life in First Line Treatment of Ovarian Cancer:

NCT06817161Ovarian Carcinoma, First Line Chemotherapy, Digestive System Disorders

Centre Francois Baclesse

Phase 3

116

Caen, Lille, Rouen

2025-04-30

Recruiting

Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients

NCT06447480Acne Vulgaris

DrugIsotretinoin

Centre Hospitalier Universitaire de Nice

Phase 3

420

Nice, Bordeaux, Nantes, Rouen, Sainte-Maxime, Argenteuil, Brest, Cenon

2025-04-29

Recruiting

Effectiveness of a Dietary Supplement in Irritable Bowel Syndrome

NCT07039747Irritable Bowel Syndrome

University Hospital, Rouen

Phase 2

100

Rouen

2025-04-22

Active, closed

Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)

NCT06814145Hypertension, Pulmonary

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

440

Nice, Montpellier, Saint-Herblain, Angers, Rouen, Le Kremlin-Bicêtre

2025-04-16

Recruiting

Mechanisms of Action on Rectal Motricity of Intrarectal Botulinum Toxin Injections

NCT05998187Fecal Incontinence

University Hospital, Rouen

Phase 3

Rouen

2025-04-15

Recruiting

Effect of Partially Hydrolyzed Formula With Synbiotics on Skin Barrier Function

NCT06943469Atopic Dermatitis (AD)

Société des Produits Nestlé (SPN)

Not applicable

400

Amiens, Caen, Grenoble, Lyon, Rouen, Tours

2025-04-10

Recruiting

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

NCT06790693Breast Cancer

DrugsCDK4/6i·Inavolisib·Letrozole

Hoffmann-La Roche

Phase 3

450

Angers, Lille, Montpellier, Paris, Plérin, Poitiers, Rennes, Rouen

2025-04-09

Active, closed

A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis

NCT06863961Atopic Dermatitis

DrugAfimkibart

Hoffmann-La Roche

Phase 2

162

Rouen, Cedex 10

2025-04-01

Active, closed

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa

NCT06840392Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

565

Nice, Brest, La Rochelle, Lyon, Reims, Rouen, Toulouse

2025-03-20

Recruiting

Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.

NCT07117058Generalized Anxiety, Introspective & Anxiety-Prone Patient, Depression, Anxiety, Survivors of Childhood Cancer

Centre Hospitalier Universitaire de Saint Etienne

Observational

545

Angers, Caen, Grenoble, Lyon, Nice, Rouen, Saint-Etienne

2025-03-18

Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT06841354Triple Negative Breast Neoplasms

DrugsAbraxane·Sacituzumab tirumotecan·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,000

Lyon, Limoges, Montpellier, Saint-Herblain, Reims, Rouen, Toulon, Paris

2025-03-16

Recruiting

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

NCT06833073Urinary Bladder Neoplasms, Non-Muscle Invasive Bladder Neoplasms, Carcinoma in Situ

DrugIntismeran autogene

Merck Sharp & Dohme LLC

Phase 2

308

Dijon, Bordeaux, Rouen, Suresnes, Paris

2025-03-11

Recruiting

Dynamic 68Ga-PSMA and 18F-FDG PET/CT Analysis Prior to 177Lu-PSMA

NCT06450548Prostate Cancer Metastatic

Centre Henri Becquerel

Not applicable

Rouen

2025-03-05

Recruiting

Irritable Bowel Syndrome Regional Cohort

NCT06900491Irritable Bowel Syndrome

University Hospital, Rouen

Observational

600

Amiens, Caen, Lille, Rouen

2025-03-04

Not yet open

Postural Training for Standing and Sitting in Men Suffering From Post-prostatectomy Urinary Incontinence

NCT06842914Men Who Have Undergone Prostatectomy

University Hospital, Rouen

Observational

Rouen, Vannes

2025-03-01

Recruiting

Tensi+ European Post-Market Clinical Follow-Up

NCT07205445Overactive Bladder

Stimuli Technology

Observational

500

Bron, Rennes, Rouen

2025-02-27

Recruiting

Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases

NCT06435468Systemic Lupus, Autoimmune Diseases, Autoinflammatory Disease, Genetic Disease

Hospices Civils de Lyon

Not applicable

400

Bron, Lille, Nice, Paris, Saint-Etienne, Grenoble, Rouen, Strasbourg

2025-02-26

Recruiting

Respiratory Rehabilitation and Sleep Quality in COPD Patients

NCT06677268COPD (Chronic Obstructive Pulmonary Disease)

University Hospital, Rouen

Not applicable

Amiens, Le Havre, Rouen

2025-02-19

Recruiting

Prospective Cohort Study of Protected Children

NCT06805682Mental Health Conditions, Physical Health Status, Child Development

Assistance Publique - Hôpitaux de Paris

Observational

220

Évreux, Lille, Metz, Rouen, Saint-Brieuc, Saint-Genest-Lerpt, Toulon

2025-02-18

Recruiting

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

NCT06612268Sickle Cell Disease

DrugEtavopivat

Novo Nordisk A/S

Phase 3

510

Bobigny, Bordeaux, Créteil, Grenoble, Lyon, Paris, Rouen

2025-02-17

Recruiting

Improvement of Symptoms After Removal of the Essure® Contraceptive Implant

NCT06355713Implant Complication, Contraceptive Device; Complications

DrugBlood sample

Hospices Civils de Lyon

Not applicable

444

Angers, Bron, Le Kremlin-Bicêtre, Lille, Marseille, Reims, Rouen, Strasbourg

2025-02-17

Active, closed

Prospective Longitudinal Multicentric Study to Evaluate Syde® Digital Endpoints in Healthy Adults

NCT06679608Healthy Adults

SYSNAV

Observational

129

Bron, Pontoise, Rouen, Vernon

2025-01-20

Recruiting

Use of Omics Methods to Classify Variations of Uncertain Significance and Improve Diagnosis of Neurogenetic Diseases

NCT06955624Neurogenetic Diseases

University Hospital, Rouen

Not applicable

Rouen

2025-01-15

Active, closed

Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis

NCT06846541Plaque Psoriasis, Psoriasis (PsO), Psoriasis, Moderate Psoriasis

Alumis Inc

Phase 3

1,680

Nice, Rouen

2025-01-08

Recruiting

Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia

NCT06602934Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease

Nantes University Hospital

Not applicable

300

Angers, Nantes, Rennes, Rouen, Toulouse

2025-01-02

Active, closed

Study of the Clearance of Minimal Residual Disease Measured at the End of First-line Treatment in Patients With Lymphoma

NCT06744075B-cell Lymphoma, Hodgkin Lymphoma

Centre Henri Becquerel

Not applicable

108

Montivilliers, Rouen

2024-12-24

Recruiting

Overview of the Mental Health of Adolescents in Therapeutci, Educational and Pedagogical Facilities in France

NCT06489912Mental Health Disorder

University Hospital, Rouen

Observational

200

Besançon, Rouen

2024-12-20

Recruiting

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

NCT06667908Carcinoma, Non-Small-Cell Lung

DrugsJNJ-90301900·Durvalumab

Johnson & Johnson Enterprise Innovation Inc.

Phase 2

130

Brest, Marseille, Paris, Rouen, Villejuif

2024-12-06

Recruiting

Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology

NCT06392997Gynecologic Disease, Gynecologic Cancer, Endometriosis, Ovarian Cancer

ZIWIG

Observational

2,500

Angers, Bordeaux, Caen, Dijon, Lyon, Neuilly-sur-Seine, Rennes, Rouen

2024-12-05

Recruiting

Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

NCT06526793B-cell Non-Hodgkin Lymphoma, Follicular Lymphoma (FL), Large B-Cell Lymphoma (LBCL)

DrugSurovatamig

AstraZeneca

Phase 2

270

Montpellier, Paris, Pierre-Bénite, Rouen

2024-11-27

Recruiting

Discontinuous Echocardiographic Subcostal Cardiac Output Measurement

NCT07177391Cardiac Output Measurement

University Hospital, Rouen

Observational

Rouen

2024-11-25

Recruiting

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

NCT05552157Alzheimers Disease, Dementia, Alzheimers Disease, Familial

DrugRemternetug

Washington University School of Medicine

Phase 2/3

280

Toulouse, Lille, Paris, Bron, Rouen

2024-11-22

Recruiting

A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

NCT06647498Alzheimers Disease, Dementia, Alzheimers Disease, Familial

DrugRemternetug

Washington University School of Medicine

Phase 2/3

280

Toulouse, Lille, Paris, Bron, Rouen

2024-11-22

Recruiting

APA (Adapted Physical Activity) for Patients With Advanced Melanoma

NCT07031830Melanoma of Skin

University Hospital, Rouen

Observational

Rouen

2024-11-18

Recruiting

Evaluation of the Influence of Aromatherapy and Music Therapy on Stress During the Management of Cerebral Arteriography

NCT06425237Patients Scheduled for Cerebral Arteriography for Diagnostic or Therapeutic Purposes

University Hospital, Rouen

Not applicable

224

Rouen

2024-11-04

Recruiting

Effectiveness of Neurodynamic Sliding Mobilisation in the "Slump" Position in Relation to the Perceptible Pain Threshold in Asymptomatic People

NCT06357715Voluntary

University Hospital, Rouen

Not applicable

Rouen

2024-10-23

Recruiting

Gelsectan® in the Treatment of Patients With Diarrhoea-predominant Irritable Bowel Syndrome

NCT06681012Irritable Bowel Syndrome (IBS), Irritable Bowel Syndrome of Diarrhea Type (IBS-D)

Devintec Sagl

Not applicable

330

Bobigny, Rouen

2024-10-22

Active, closed

Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

NCT06641089Arthritis, Psoriatic

DrugsSonelokimab·Risankizumab

MoonLake Immunotherapeutics AG

Phase 3

600

Caluire-et-Cuire, Montpellier, Narbonne, Nice, Rouen, Tours

2024-10-15

Active, closed

Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis Naive to Biologic Disease-Modifying Antirheumatic Drug

NCT06641076Arthritis, Psoriatic

DrugSonelokimab

MoonLake Immunotherapeutics AG

Phase 3

960

Cahors, Caluire-et-Cuire, Échirolles, Montpellier, Narbonne, Nice, Rouen, Tours

2024-10-15

Active, closed

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

NCT06598943Ulcerative Colitis, Ulcerative Colitis Chronic

DrugMirikizumab

Eli Lilly and Company

Phase 2

143

Créteil, Grenoble, La Roche-sur-Yon, Nice, Pierre-Bénite, Rouen

2024-10-10

Active, closed

Comparison of the Flexibility of the Perineum in Primiparous Women Using the Medical Device Emagina During 90 Days of Their Pregnancy Compared to Those Having a Standard Pregnancy Follow-up

NCT06542744Pregnancy, Childbirth

Mumming

Not applicable

Boulogne-Billancourt, Coutances, Grandchamps-des-Fontaines, Marseille, Montpellier, Paris, Ronchin, Rouen

2024-10-10

Recruiting

Viral Epidemiology of Bronchiolitis After Nirsevimab Implementation and Respiratory Evolution in Infants

NCT06636955Acute Bronchiolitis

University Hospital, Rouen

Observational

900

Rouen

2024-10-07

Recruiting

Efficacy of INM004 in Children With STEC-HUS

NCT06389474Hemolytic-Uremic Syndrome

Inmunova S.A.

Phase 3

220

Bordeaux, Lyon, Montpellier, Nantes, Paris, Rouen

2024-10-05

Recruiting

Efficacy of Glutamine Supplementation in Patients Suffering From Irritable Bowel Syndrome With Impaired Intestinal Permeability

NCT06291038Irritable Bowel Syndrome

University Hospital, Rouen

Not applicable

Amiens, Caen, Le Havre, Rouen

2024-10-03

Recruiting

Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure

NCT06207383Atrial Fibrillation, Persistent, Heart Failure

University Hospital, Geneva

Not applicable

220

Rouen

2024-10-01

Recruiting

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

NCT06510374Intermediate Risk Non-Muscle Invasive Bladder Cancer

DrugNadofaragene Firadenovec

Ferring Pharmaceuticals

Phase 3

454

Clermont-Ferrand, Toulouse, Nantes, Bordeaux, Rouen, Nîmes, Lyon, Paris

2024-10-01

Not yet open

Home-based Nurse Intervention in the Care of High Risk of Death Patients After Discharge From Geriatric Department

NCT06481917Health Services for the Aged, Advance Care Planning

Lille Catholic University

Not applicable

104

Amiens, Caen, Lille, Lomme, Rouen

2024-10

Recruiting

A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease

NCT06613698Liver Diseases, Alcoholic

DrugGSK4532990

GlaxoSmithKline

Phase 2

393

Angers, Bobigny, Créteil, Lille, Montpellier, Rouen

2024-09-27

Recruiting

RAT-HEMATO : Return to Work After Malignant Hemopathy

NCT06262789Leukemia, Lymphoma, Multiple Myeloma

University Hospital, Angers

Not applicable

264

Angers, Brest, Caen, Cholet, Montivilliers, Morlaix, Rennes, Rouen

2024-09-27

Recruiting

Medico-economic Evaluation of Robot-assisted Laparoscopy Compared With Conventional Laparoscopy in Hysterectomy for Endometrial Cancer.

NCT06348719Hysterectomies for Low- or Intermediate-risk Endometrial Carcinoma

Rennes University Hospital

Not applicable

1,680

Lille, Limoges, Paris, Pierre-Bénite, Plérin, Rennes, Rouen, Saint-Etienne

2024-09-23

Active, closed

STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss

NCT06571383Obesity

DrugSemaglutide

Novo Nordisk A/S

Phase 4

500

Lille, Nice, Paris, Rouen, Toulouse

2024-09-17

Recruiting

Predictive Value of a Preliminary Swallowing Test Compared to Postoperative Nasofibroscopy to Identify Vocal Cord Paralysis After Pulmonary Resection

NCT05193240Adults Patients Undergoing Major Lung Resection in the Context of Lung Cancer

University Hospital, Rouen

Not applicable

Rouen

2024-09-11

Recruiting

A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease

NCT06572384Lung Diseases, Interstitial

DrugBelimumab

GlaxoSmithKline

Phase 3

440

Angers, Le Kremlin-Bicêtre, Lille, Pessac, Rouen, Toulouse

2024-09-11

Recruiting

Interest of Intensive Postoperative Rehabilitation Following Minimally Invasive Lung Resection

NCT06202222Lung Cancer

University Hospital, Rouen

Not applicable

184

Valenciennes, Caen, Rouen

2024-09-09

Active, closed

A Study of TAK-279 in Participants With Moderate-to-Severe Plaque Psoriasis

NCT06550076Plaque Psoriasis

DrugZasocitinib

Takeda

Phase 3

2,099

Martigues, Le Mans, Rouen, Saint-Etienne

2024-09-04

Not yet open

Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients

NCT06338345Cardiogenic Shock, Post-cardiac Surgery, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication

University Hospital, Grenoble

Not applicable

225

Clermont-Ferrand, Dijon, Paris, Rouen, Toulouse

2024-09-01

Recruiting

Perioperative Dynamics of Energy Expenditure in Oesophagectomy Patients

NCT06921668Oesophagectomy

University Hospital, Rouen

Observational

120

Amiens, Brest, Rouen, Vandœuvre-lès-Nancy

2024-09-01

Recruiting

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

NCT06452277Advanced Non-small Cell Lung Cancer, HER2 Mutation

DrugsSevabertinib·Pemetrexed·Cisplatin·Carboplatin

Bayer

Phase 3

444

La Tronche, Pierre-Bénite, Brest, Mulhouse, Lille, Bordeaux, Limoges, Rouen

2024-08-28

Active, closed

Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

NCT06531109Alopecia Areata

DrugRitlecitinib

Pfizer

Observational

450

Bordeaux, Argenteuil, Caen, Dijon, La Tronche, Lille, Rennes, Rouen

2024-08-07

Recruiting

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

NCT06380751Advanced Breast Cancer

DrugsSaruparib·Camizestrant·Exemestane·Anastrozole

AstraZeneca

Phase 3

788

Angers, Besançon, Lille, Lyon, Marseille, Paris, Rouen, Saint-Herblain

2024-08-01

Active, closed

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

NCT06445023Chronic Spontaneous Urticaria

DrugBarzolvolimab

Celldex Therapeutics

Phase 3

963

Pierre-Bénite, La Tronche, Martigues, Nantes, Nice, Paris, Rouen

2024-07-11

Active, closed

Transorb™ Self-Gripping Resorbable Mesh in High-risk Subjects Undergoing Open Repair of Ventral Hernia

NCT06449378Hernia, Hernia, Ventral, Hernia, Abdominal, Hernia Abdominal Wall

Medtronic - MITG

Not applicable

163

Colombes, Lille, Lyon, Reims, Rouen, Strasbourg

2024-07-02

Recruiting

A Usability Validation of the MuCopilot Mobile Application, a Digital Tool for the Unsupervised Objective Assessment of Cystic Fibrosis

NCT06132048Cystic Fibrosis

Ad scientiam

Not applicable

Rouen

2024-07-01

Recruiting

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

NCT06427304Cardiac Amyloidosis

Gérond'if

Observational

637

Paris, Nantes, Poitiers, Rouen, Montpellier, Toulouse, Amiens, Angers

2024-07-01

Active, closed

A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

NCT06468228Hidradenitis Suppurativa

DrugLutikizumab

AbbVie

Phase 3

1,400

Lyon, St-Priest-en-Jarez, Martigues, Rouen, Paris, Reims

2024-06-27

Recruiting

POP-UP: a Single-arm, Two-cohort Study: an 8-week Trimodal Pre-habilitation Program for Patients With Pancreatic Ductal Adenocarcinoma and Oesogastric

NCT06275737Pancreatic Ductal Adenocarcinoma, Esophageal Cancer

GERCOR - Multidisciplinary Oncology Cooperative Group

Not applicable

Dijon, Grenoble, Lille, Marseille, Reims, Rouen, Saint-Cloud, Saint-Herblain

2024-06-24

Recruiting

A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

NCT06455449Polymyositis, Dermatomyositis

AstraZeneca

Phase 3

240

Angers, Brest, Le Mans, Lille, Lyon, Paris, Reims, Rouen

2024-06-20

Recruiting

Predictive Properties of the 6-Minute Stepper Test for Mortality in COPD

NCT06703359COPD

ADIR Association

Observational

250

Rouen

2024-06-01

Recruiting

Study of the Plasma and Urinary cfDNA of in Kidney Transplant Patients

NCT06910527Transplant Rejection, Transplant Kidney

Poulet Geoffroy

Observational

250

Rouen

2024-05-30

Active, closed

A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis

NCT06407934Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 3

1,541

Antony, Nice, Paris, Pierre-Bénite, Reims, Romans-sur-Isère, Rouen, Toulouse

2024-05-08

Active, closed

A Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodromal Stage of Alzheimer's Disease (AD)

NCT06402838Alzheimer's Disease

Hoffmann-La Roche

Phase 2

256

Bron, Lille, Marseille, Paris, Rouen, Saint-Herblain, Strasbourg, Toulouse

2024-05-02

Active, closed

A Study Evaluating APG777 in Atopic Dermatitis

NCT06395948Atopic Dermatitis

DrugAPG777

Apogee Therapeutics, Inc.

Phase 2

470

Rouen, Martigues, Nantes

2024-04-29

Recruiting

Nebulized Fentanyl in Healthy Volunteers

NCT06281951Analgesia, Emergencies

University Hospital, Rouen

Phase 1

Rouen

2024-04-26

Recruiting

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

NCT06312137Non Small Cell Lung Cancer

DrugsSacituzumab tirumotecan·Pemetrexed·Gemcitabine·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

780

Brest, Toulouse, Rouen, Limoges, Valenciennes, Clermont-Ferrand, Bron, Toulon

2024-04-03

Active, closed

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

NCT06200207Heart Failure, Systemic Inflammation

DrugZiltivekimab

Novo Nordisk A/S

Phase 3

673

Chambray-lès-Tours, Poitiers, Rennes, Rouen, Toulon, Valenciennes, Vandœuvre-lès-Nancy

2024-04-01

Recruiting

Effectiveness of an Immune-guided Cytomegalovirus Infection Preventive Strategy Compared to a Universal Prophylactic Strategy in Renal Transplant Patients

NCT05708508Kidney Transplant Infection

University Hospital, Rouen

Phase 3

144

Rouen

2024-03-28

Recruiting

Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy

NCT05952167Radiculopathy, Cervical

Centre Hospitalier Departemental Vendee

Not applicable

206

La Roche-sur-Yon, La Rochelle, Le Puy-en-Velay, Limoges, Nantes, Paris, Reims, Rouen

2024-03-25

Recruiting

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

NCT06256588Neoplasms, Head and Neck

DrugDostarlimab

GlaxoSmithKline

Phase 3

864

Ars-Laquenexy, Caen, Dijon, Marseille, Poitiers, Quimper, Rennes, Rouen

2024-03-21

Recruiting

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

NCT05939414Oligometastatic Prostate Cancer (OMPC)

DrugsPiflufolastat·Lu-PSMA

Novartis Pharmaceuticals

Phase 3

450

Saint-Cloud, Bordeaux, Bron, Clermont-Ferrand, Rouen, Saint-Herblain

2024-03-12

Recruiting

EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION

NCT06462287Apnea, Obstructive

University Hospital, Rouen

Phase 2

Rouen

2024-03-05

Active, closed

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor

NCT06241118Dermatitis Atopic

DrugsPimecrolimus·Amlitelimab·Tacrolimus

Sanofi

Phase 3

464

Bordeaux, Clermont-Ferrand, Créteil, Lille, Paris, Rouen, Saint-Pierre

2024-02-29

Recruiting

Efficacy and Safety of Switching From Anti-C5 Antibody Treatment to Iptacopan Treatment in Study Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

NCT05935215Atypical Hemolytic Uremic Syndrome

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

Bordeaux, Paris, Rouen, Toulouse, Tours

2024-02-28

Recruiting

HRD Tests for Ovarian cancER

NCT06152731Ovarian Cancer

Centre Francois Baclesse

Phase 2

Amiens, Caen, Lille, Rouen

2024-02-15

Recruiting

Tolerance of Intra-articular Injection Autologous Stromal Vascular Fraction for the Treatment of Rhizarthrosis

NCT05708430Rhizarthrosis

University Hospital, Rouen

Phase 2

Amiens, Caen, Rouen

2024-02-15

Recruiting

Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study

NCT06166329Non-severe Pulmonary Embolism, Pulmonary Embolism, Non-high-risk Pulmonary Embolism, Pulmonary Embolism Acute

University Hospital, Rouen

Not applicable

180

Rouen

2024-02-09

Recruiting

DOR/TDF/3TC Switch With M184V/I in People With Controlled HIV (Drive Off-Road)

NCT06034938Hiv

University Hospital, Caen

Phase 2

Caen, Orléans, Rouen, Tourcoing

2024-02-08

Recruiting

Study of Olverembatinib (HQP1351) in Patients With CML-CP

NCT06423911Chronic Myeloid Leukemia, CML, CML, Chronic Phase

DrugsBosutinib·Olverembatinib

Ascentage Pharma Group Inc.

Phase 3

333

Amiens, Bobigny, Nice, Rouen, Toulouse

2024-02-05

Recruiting

Impact of a Personalized Medication Plan on Duration of Treatment With Potent Opioids in Acute Non-cancer Musculoskeletal Pain.

NCT05905146Acute Pathology of the Locomotor System

University Hospital, Rouen

Not applicable

200

Lille, Nîmes, Rouen

2024-01-18

Recruiting

ctDNA in CRC Patients Undergoing Curative-intent Surgery for Liver Metastases

NCT05787197Metastatic Colorectal Cancer, Circulating Tumor DNA

GERCOR - Multidisciplinary Oncology Cooperative Group

Observational

232

Besançon, Bordeaux, Lille, Lyon, Paris, Pessac, Poitiers, Rouen

2024-01-09

Active, closed

Contribution of Residual Tumour DNA Testing on the Surgical Bed

NCT05934929Squamous Cell Carcinoma of the Oral Cavity

Centre Henri Becquerel

Not applicable

Rouen

2024-01-08

Recruiting

Safety and Efficacy of RVU120 Combined With Venetoclax for Treatment of Relapsed/Refractory AML

NCT06191263Acute Myeloid Leukemia

DrugsRVU120·Venetoclax

Ryvu Therapeutics SA

Phase 2

Grenoble, Le Mans, Lille, Marseille, Nice, Nîmes, Paris, Rouen

2024-01-05

Recruiting

Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser

NCT05916963Kidney Stone

DrugFurosemide

University Hospital, Tours

Phase 3

374

Angers, Lyon, Nice, Nîmes, Rennes, Rouen, Toulouse, Tours

2024-01-04

Not yet open

NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases

NCT06182956Interstitial Lung Disease, Acute Respiratory Failure

ADIR Association

Not applicable

Rouen

2024-01-01

Active, closed

Circulating Tumor DNA Sequencing in Patients With Peripheral T-cell Lymphomas

NCT06089941Peripheral T Cell Lymphoma

Centre Henri Becquerel

Observational

Rouen

2024-01-01

Recruiting

A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone Lymphoma

NCT06149286Relapsed/Refractory Follicular Lymphoma, Relapsed/Refractory Marginal Zone Lymphoma (R/R MZL)

DrugsOdronextamab·Lenalidomide·Rituximab

Regeneron Pharmaceuticals

Phase 3

580

Marseille, Rennes, Tours, Bordeaux, Pessac, Lille, Rouen, Nantes

2023-12-28

Active, closed

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

NCT06140836Carcinoma, Non-Small-Cell Lung

DrugsRepotrectinib·Crizotinib

Bristol-Myers Squibb

Phase 3

190

Strasbourg, Pessac, Dijon, Rouen, La Tronche, Saint-Herblain, Pierre-Bénite, Paris

2023-12-21

Recruiting

Improved Hemodynamic Tolerance of Intermittent Hemodialysis Sessions in Intensive Care Unite Using Citrate- vs Acetate-based Dialysate

NCT05936710Intradialytic Hypotension

Centre Hospitalier de Bethune

Not applicable

Béthune, Caen, Dijon, Nancy, Rouen

2023-12-07

Active, closed

A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines

NCT05976243Chronic Inducible Urticaria

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

362

Grenoble, Montpellier, Nantes, Paris, Pierre-Bénite, Rouen, Toulouse

2023-12-07

Recruiting

Study of the Intestinal Microbiota

NCT07058961Intestinal Microbiota Between Different Groups

University Hospital, Rouen

Observational

100

Rouen

2023-11-28

Active, closed

A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)

NCT06113471NonSegmental Vitiligo

DrugPovorcitinib

Incyte Corporation

Phase 3

450

Brest, Le Mans, Martigues, Nice, Rouen

2023-11-27

Active, closed

Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.

NCT06042478Chronic Spontaneous Urticaria

DrugsOmalizumab·Remibrutinib

Novartis Pharmaceuticals

Phase 3

470

Nice, Grenoble, La Rochelle, Pierre-Bénite, Rouen

2023-11-15

Active, closed

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

NCT06062420Neoplasms, Head and Neck

DrugsRemzistotug·Nelistotug·Belrestotug·Dostarlimab

GlaxoSmithKline

Phase 2

316

Bordeaux, Caen, Marseille, Paris, Rouen, Villejuif

2023-11-14

Active, closed

Evolution of CMV Antiviral T-cell Immunity Over the Next Six Months Initiation of Treatment With Belatacept.

NCT05708534Kidney Transplant Infection

DrugBelatacept

University Hospital, Rouen

Observational

Rouen

2023-11-14

Recruiting

ACP-204 in Adults With Alzheimer's Disease Psychosis

NCT06159673Alzheimer's Disease Psychosis

DrugACP-204

ACADIA Pharmaceuticals Inc.

Phase 2/3

1,074

Bron, Colmar, Dijon, Limoges, Lyon, Paris, Rouen, Toulouse

2023-11-14

Active, closed

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

NCT06074588Non-small Cell Lung Cancer (NSCLC)

DrugsTaxotere·Sacituzumab tirumotecan·Pemetrexed·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

556

Bordeaux, Lyon Cedex08, Rouen, Paris

2023-11-12

Recruiting

Study Evaluating the Analgesic Efficacy of Capsaicin 8% Patches in Chronic Coccygodynia.

NCT06023706Coccyx Disorder, Neuropathic Pain, Coccygodynia

DrugCapsaicin

Nantes University Hospital

Phase 3

188

Brest, La Roche-sur-Yon, Nantes, Paris, Rouen

2023-11-08

Active, closed

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

NCT06087835Chronic Kidney Disease With High Proteinuria

DrugDapagliflozin

AstraZeneca

Phase 3

1,835

La Tronche, Mulhouse, Nice, Nîmes, Rouen, Saint-Priest-en-Jarez, Strasbourg, Tours

2023-11-07

Recruiting

Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

NCT05566769Neuromyelitis Optica

Ad scientiam

Not applicable

103

Lille, Marseille, Montpellier, Nice, Paris, Rouen, Strasbourg, Toulouse

2023-11-03

Recruiting

Cellular and Molecular Biomarkers in Patients With Lichen Planus

NCT06451744Lichen Planus

Institut Pasteur

Not applicable

Besançon, Bobigny, Paris, Reims, Rouen

2023-11-01

Recruiting

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

NCT05943535Progressive Pulmonary Fibrosis, Interstitial Lung Disease

DrugTreprostinil

United Therapeutics

Phase 3

698

Bobigny, Bron, Caen, Marseille, Rouen, Tours

2023-10-30

Recruiting

Influence of Body Composition on Chemotherapy Outcomes in Localized Breast Cancer

NCT05858398Breast Cancer

Centre Henri Becquerel

Not applicable

Rouen

2023-10-25

Active, closed

Impact of Microglial Activation on Synaptic Density in Alzheimer's Disease

NCT05911178Alzheimer Disease

Centre Hospitalier St Anne

Not applicable

Lille, Paris, Rouen

2023-10-18

Recruiting

NUTritional Impact of a Hypocaloric Hyperprotein Diet Before Obesity Surgery

NCT04942093Diet, Healthy, Obesity, Visceral, Bariatric Surgery Candidate

University Hospital, Rouen

Not applicable

200

Dieppe, Le Havre, Rouen

2023-10-09

Recruiting

Effectiveness of a Hip Abductor Training in Women With Stress Urinary Incontinence

NCT05635175Women With Stress Urinary Incontinence

University Hospital, Rouen

Not applicable

Caen, Rouen, Saint-Étienne-du-Rouvray

2023-09-28

Recruiting

Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma

NCT06044051Asthma in Children, Asthma

University Hospital, Rouen

Not applicable

100

Rouen

2023-09-26

Active, closed

MS-DETECT: Early Detection of Multiple Sclerosis Progression With MSCopilot® Detect

NCT05816122Multiple Sclerosis

Ad scientiam

Not applicable

336

Lille, Lomme, Marseille, Nice, Rouen

2023-09-22

Active, closed

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

NCT06047080Large B-Cell Lymphoma

DrugsPolatuzumab Vedotin·Glofitamab·Doxorubicin·Prednisone

Hoffmann-La Roche

Phase 3

1,130

Lille, Lyon, Marseille, Montpellier, Nantes, Pessac, Rennes, Rouen

2023-09-18

Recruiting

Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:

NCT06036706Meningioma, Radiation Toxicity

Centre Francois Baclesse

Not applicable

108

Caen, Le Havre, Rouen

2023-09-13

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

NCT06023589Asthma

DrugTezepelumab

AstraZeneca

Phase 3

231

Brest, Bron, Créteil, Marseille, Paris, Rouen, Vandœuvre-lès-Nancy

2023-08-24

Recruiting

Coroflex® ISAR NEO PMCF Study

NCT05698732Coronary Artery Disease (CAD), Ischemic Heart Disease

Fundación EPIC

Observational

3,000

Aix-en-Provence, Ajaccio, Bordeaux, Caen, Colmar, Lille, Paris, Rouen

2023-08-04

Recruiting

Immediate Prescription of a Hypouricemic Treatment, Febuxostat, Compared to Its Delayed Administration

NCT05109936Gout

University Hospital, Rouen

Phase 3

128

Caen, Cherbourg, Dieppe, Elbeuf, Le Havre, Rouen

2023-08-02

Recruiting

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

NCT05855200Colonic Neoplasms, Neoplasms, Colon

DrugsCapeox·Dostarlimab·Folfox

GlaxoSmithKline

Phase 3

892

Lyon, Marseille, Nantes, Paris, Pessac, Rennes, Rouen, Saint-Priest-en-Jarez

2023-08-01

Recruiting

Lung cAncer Robotic Comparative Study

NCT06038227Lung Cancer

Intuitive Surgical

Observational

600

Marseille, Rouen, Toulouse

2023-07-15

Recruiting

Virtual Reality Exposure Therapy for Gambling Disorder

NCT04467502Gambling Disorder

University Hospital, Lille

Not applicable

124

Amiens, Boulogne-sur-Mer, Caen, Lille, Lomme, Montreuil-sur-Mer, Rouen, Saint-Amand-les-Eaux

2023-07-12

Recruiting

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

NCT05980949Psychosis Associated With Alzheimer's Disease

DrugKarXT

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 3

1,000

Nice, Tours, Reims, Rouen, Toulouse

2023-07-11

Not yet open

Assessment and Prevention of Caregiver Burden in Oncology

NCT05750836Oncology, Caregiver Burden

Institut Cancerologie de l'Ouest

Not applicable

250

Cholet, Nice, Rouen, Saint-Herblain, Saint-Lô

2023-07

Recruiting

Relevance of Whole-body Computed Tomography Prescription in the Emergency Department : an Identification Tool for Low Risk Patients

NCT05588791Trauma

University Hospital, Rouen

Observational

2,018

Rouen

2023-06-23

Recruiting

IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

NCT05742607Non Small Cell Lung Cancer

DrugDurvalumab

Innate Pharma

Phase 2

Angers, Caen, Lille, Limoges, Lyon, Marseille, Rennes, Rouen

2023-06-23

Recruiting

Change History and Adopt a Robotic SolutioN for anGioplasty procedurE

NCT05853419Coronary Disease

Robocath

Observational

500

Brest, Rouen, Saint-Denis

2023-06-20

Active, closed

Premedication to Reduce Amivantamab Associated Infusion Related Reactions

NCT05663866Carcinoma, Non-Small-Cell Lung

DrugsMontelukast·Lazertinib·Amivantamab·Methotrexate

Janssen Research & Development, LLC

Phase 2

Brest, Lyon, Paris, Rouen, Strasbourg

2023-05-18

Recruiting

Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)

NCT06945861Thrombotic Thrombocytopenic Purpura (TTP)

University Hospital, Rouen

Observational

Rouen

2023-05-11

Active, closed

Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System in Complex PCI Patients

NCT05705973Cardiovascular Disease, Coronary Artery Occlusion, Ischemic Heart Disease

Terumo Europe N.V.

Observational

3,000

Besançon, Bron, Essey-lès-Nancy, Lyon, Massy, Nîmes, Rouen, Suresnes

2023-04-25

Recruiting

Alloreactive Memory B Lymphocytes and Anti-HLA Sensitization

NCT07011238Kidney Transplant

University Hospital, Rouen

Observational

Rouen

2023-04-17

Recruiting

Modelling of Pharyngeal Laryngeal Effectiveness

NCT06014710Swallowing Disorders

University Hospital, Toulouse

Not applicable

520

Bordeaux, Rouen, Toulouse, Tours

2023-04-14

Recruiting

Cohort of Patients with Alzheimer's Disease and Their Families.

NCT05516667Alzheimer Disease

University Hospital, Toulouse

Observational

1,000

France, Montpellier, Rouen, Toulouse

2023-04-06

Active, closed

A Study Evaluating the Effect of Filgotinib in Participants With Active Axial Spondyloarthritis

NCT05785611Axial Spondyloarthritis

DrugFilgotinib

Alfasigma S.p.A.

Phase 3

495

Boulogne-Billancourt, Lyon, Orléans, Pierre-Bénite, Rouen

2023-04-05

Active, closed

A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma

NCT05692180Asthma

DrugBenralizumab

AstraZeneca

Phase 3

Créteil, Lyon, Rouen

2023-04-05

Recruiting

Phenotypic and Molecular Characterisation of Cerebral Amyloid Angiopathy

NCT06864000Cerebral Amyloid Aβ Angiopathy

University Hospital, Rouen

Observational

100

Rouen

2023-03-31

Recruiting

Effects of Oral Glutamine Supplementation on Insulin Resistance and Functional Intestinal Disorders in Obese Patients.

NCT04883515Obesity, Insulin Resistance

University Hospital, Rouen

Not applicable

110

Rouen

2023-03-01

Recruiting

Long-term Outcomes of Conduction System Pacing: a National Multicenter Observational Study - NORMAND'HIS / STIMU'HIS

NCT06088927Conduction System Pacing

University Hospital, Rouen

Observational

2,500

Caen, Elbeuf, La Rochelle, Le Havre, Lille, Lomme, Rennes, Rouen

2023-03-01

Recruiting

Evaluation of the Prevalence of BP180 and BP230 Autoantibodies in the Serum of Patients With Pruritus Under Immunotherapy

NCT05689463Patients With Chronic Pruritus for More Than 1 Month Who Have Received Immunotherapy

University Hospital, Rouen

Not applicable

100

Rouen

2023-02-23

Recruiting

Medico-economic Evaluation Rehabilitation by Serious Games at Home for the Management of Patients With Parkinson's Disease Suffering From Gait and Balance Disorders

NCT04720365Patients With Parkinson's Disease

University Hospital, Rouen

Not applicable

Bordeaux, Lille, Paris, Rouen

2023-02-15

Recruiting

Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse

NCT05540561Nitrous Oxide Abuse

University Hospital, Lille

Observational

356

Béthune, Boulogne-sur-Mer, Calais, Lens, Lille, Nantes, Roubaix, Rouen

2023-01-30

Recruiting

Usefulness of High Resolution Manometry in Constipation

NCT04623359Constipation

University Hospital, Rouen

Not applicable

Caen, Lille, Rouen

2023-01-25

Active, closed

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer

NCT05563220Breast Cancer, Metastatic Breast Cancer

DrugsAlpelisib·Capivasertib·Elacestrant·Everolimus

Stemline Therapeutics, Inc.

Phase 1/2

435

Lyon, Montpellier, Rouen, Toulouse, Villejuif

2023-01-24

Active, closed

Real-Time Monitoring of Circulating Tumor DNA and Study of Prognostic Factors in Patients Treated With CAR-T Cells

NCT05675982Diffuse Large B Cell Lymphoma

Centre Henri Becquerel

Not applicable

Rouen

2023-01-13

Recruiting

Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

NCT05658575Acute Gout Flare, Gout Attack, Gout Flare, Gouty Arthritis

DrugDapansutrile

Olatec Therapeutics, Inc.

Phase 2/3

300

Bordeaux, Lomme, Paris, Rouen

2023-01-06

Active, closed

Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations

NCT05687266NSCLC

DrugsDato-DXd·Durvalumab·Pemetrexed·Paclitaxel

AstraZeneca

Phase 3

1,350

Brest, Créteil, Gleizé, Montpellier, Nîmes, Paris, Rouen, Saint-Quentin

2022-12-29

Recruiting

Screening for Hepatitis B, Hepatitis C and AIDS Viruses Using Dried Blood Spot

NCT05390424Hepatitis B, Hepatitis C, AIDS

University Hospital, Rouen

Not applicable

500

Avranches, Barentin, Dieppe, Elbeuf, Gisors, Le Havre, Pont-Audemer, Rouen

2022-12-02

Active, closed

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Observational

6,000

Strasbourg, Marseille, Dijon, Bordeaux, Nantes, Saint-Étienne-de-Montluc, Lyon, Rouen

2022-11-21

Recruiting

Benefit of Paramedical Care in Accompanying Caregivers of Patients That Had Surgery for an Head and Neck Invasive Cancer

NCT05542706Head and Neck Cancer

Centre Henri Becquerel

Not applicable

Rouen

2022-10-31

Recruiting

Diagnostic Accuracy of Optimized Diffusion-Weighted Imaging for Detecting Anterior Ischemic Optic Neuropathy

NCT04451265Neuro-Ophthalmology

Fondation Ophtalmologique Adolphe de Rothschild

Observational

250

Lille, Paris, Rouen

2022-10-26

Active, closed

A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp

NCT05387525Keratosis, Actinic

DrugDiclofenac Sodium

Almirall, S.A.

Phase 4

447

Lille, Marseille, Nice, Paris, Rouen, Saint-Priest-en-Jarez

2022-10-24

Recruiting

Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer

NCT05241405Breast Cancer, Fatigue

Centre Francois Baclesse

Not applicable

354

Amiens, Bayeux, Beuvry, Caen, Calais, Cherbourg, Coudekerque-Branche, Rouen

2022-09-27

Recruiting

Modifying Factors in Striated Muscle Laminopathies

NCT05394506Laminopathies, Emery Dreifuss Muscular Dystrophy 2, LMNA-Related Congenital Muscular Dystrophy, Dilated Cardiomyopathy-1A

Institut National de la Santé Et de la Recherche Médicale, France

Not applicable

Bron, Paris, Montpellier, Rennes, Nantes, Rouen, Garches

2022-09-08

By invitation

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

NCT04905693Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Progressive Pulmonary Fibrosis

DrugTreprostinil

United Therapeutics

Phase 3

1,850

Marseille, Caen, Toulouse, Tours, Rouen, Amiens, Bobigny, Bron

2022-09-06

Recruiting

Home High Flow Oxygen to Reduce Acute Exacerbation of COPD

NCT05196698Chronic Obstructive Pulmonary Disease

University Hospital, Rouen

Not applicable

406

Rouen

2022-08-26

Active, closed

A Study to Learn About the Safety of Diranersen (BIIB080) Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age

NCT05399888Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia

Biogen

Phase 2

416

Strasbourg, Toulouse, Montpellier, Saint-Herblain, Lille, Paris, Rouen

2022-08-24

Recruiting

A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)

NCT05511363Psychosis Associated With Alzheimer's Disease

DrugKarXT

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 3

410

Reims, Villeurbanne, Dijon, Rouen

2022-08-23

Active, closed

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

NCT05492578Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2/3

1,856

Antony, Bordeaux, Clermont-Ferrand, Créteil, Lille, Nice, Reims, Rouen

2022-08-22

Recruiting

Prediction of Hepatocellular Carcinoma Recurrence After Curative Treatment by Monitoring Circulating Tumor DNA

NCT05375370Hepatocellular Carcinoma

University Hospital, Rouen

Not applicable

150

Rouen

2022-08-04

Active, closed

Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

NCT05352672Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,546

Pierre-Bénite, Dijon, Besançon, Bordeaux, Lille, La Tronche, Poitiers, Rouen

2022-07-14

Recruiting

Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery

NCT04918173Congenital Antithrombin Deficiency

Octapharma

Phase 3

Bron, Reims, Rouen

2022-07-01

Active, closed

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT04975997Multiple Myeloma

DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone

Celgene

Phase 3

939

Argenteuil, La Roche-sur-Yon, Lille, Nancy, Nantes, Paris, Pessac, Rouen

2022-06-23

Active, closed

A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)

NCT05374512Breast Cancer

DrugsEribulin·Dato-DXd·Nab-paclitaxel·Capecitabine

AstraZeneca

Phase 3

644

Bordeaux, Dijon, Limoges, Lyon, Marseille, Montpellier, Paris, Rouen

2022-05-16

Recruiting

Skeletal Muscle-derived Cell Implantation for Treatment of Fecal Incontinence

NCT04976153Fecal Incontinence

Innovacell GmbH

Phase 3

290

Paris, Rennes, Rouen

2022-05-11

Recruiting

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

NCT05061550Non-small Cell Lung Cancer

DrugsAZD0171·Pemetrexed/Cisplatin·Pemetrexed/Carboplatin·Monalizumab

AstraZeneca

Phase 2

630

Avignon, Bobigny, Bordeaux, Limoges, Rennes, Rouen, Suresnes, Toulon

2022-04-14

Active, closed

Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)

NCT05348577Prostate Cancer

DrugsCapivasertib·Docetaxel

AstraZeneca

Phase 3

1,035

Bordeaux, Brest, Clermont-Ferrand, Créteil, Montpellier, Paris, Rouen, Saint-Herblain

2022-03-25

Active, closed

A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma

NCT04980222Lymphoma

DrugsGlofitamab·Tocilizumab·Vincristine·Doxorubicin

Hoffmann-La Roche

Phase 2

Créteil, Rouen

2022-03-22

Recruiting

Effects of Fecal Microbiota Transplantation

NCT07196189Eating Disorders Symptoms

University Hospital, Rouen

Observational

Rouen

2022-03-16

Active, closed

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

NCT05132582HER2 Positive Breast Cancer

DrugsPerjeta·Tucatinib·Herceptin·Pertuzumab

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

654

Rouen, Bordeaux, Montpellier, Saint-Herblain, Avignon, Dijon, Besançon, Bobigny

2022-03-07

Recruiting

Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis

NCT05146180Endocarditis

Centre Henri Becquerel

Not applicable

Rouen

2022-02-24

Recruiting

Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders

NCT07205003Neurocognitive Disorders, Alzheimer's Disease

University Hospital, Rouen

Observational

140

Rouen

2022-02-15

Active, closed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)

NCT05262023Frontotemporal Dementia

Denali Therapeutics Inc.

Phase 1/2

Nantes, Rouen, Toulouse

2022-02-01

Recruiting

REmote iSchemic condItioning in Lymphoma PatIents REceiving ANthraCyclinEs

NCT05223413Anthracycline-induced Cardiac Toxicity, Lymphoma

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

Not applicable

608

Montivilliers, Rouen

2022-01-18

Active, closed

LVIS™ Evo™ and HydroCoil® Embolic System for Intracranial Aneurysm Treatment

NCT04999423Intracranial Aneurysm

Microvention-Terumo, Inc.

Observational

206

Brest, Limoges, Lyon, Marseille, Paris, Rouen

2022-01-14

Active, closed

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

NCT05269394Alzheimers Disease, Dementia, Alzheimers Disease, Familial

DrugsE2814·Lecanemab

Washington University School of Medicine

Phase 2/3

197

Toulouse, Lille, Paris, Bron, Rouen

2021-12-22

Active, closed

A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

NCT04819100Carcinoma, Non-Small-Cell Lung

DrugSelpercatinib

Eli Lilly and Company

Phase 3

152

Lyon, Marseille, Rouen, Le Plessis-Robinson, Villejuif, Paris

2021-12-20

Not yet open

Impact of Allo-HSCT on Bone Remodeling: Evolution of Bone Mineral Density and Architecture Measured by Bone Densitometry

NCT05161026Myeloid Leukemia, Acute

University Hospital, Caen

Not applicable

120

Amiens, Caen, Lille, Rouen

2021-12-10

Recruiting

Post-Market Product Surveillance of Intracranial ANeurysms Treated With Commercial ReGistered ACANDIS Devices in FrancE

NCT06940934Intracranial Aneurysms

Acandis GmbH

Observational

100

Rouen

2021-12-01

Active, closed

Sirolimus-coated Balloon Versus Drug-eluting Stent in Native Coronary Vessels - TRANSFORM II

NCT04893291Coronary Artery Disease, Coronary Artery Stenosis

Fondazione Ricerca e Innovazione Cardiovascolare ETS

Not applicable

1,820

Essey-lès-Nancy, La Rochelle, Le Coudray, Nantes, Rouen, St-Malo

2021-11-16

Recruiting

Bradykinin-degradating Enzymes Activities in Angiotensin-Converting Enzyme Inhibitors-associated Angioedema

NCT04763577Angio-Oedema Caused by Angiotensin-Converting-Enzyme Inhibitor

University Hospital, Grenoble

Observational

243

Grenoble, Lille, Paris, Rouen

2021-10-27

Recruiting

Endothelin-1 Receptor Blockade in Resistant Hypertension

NCT04388124Resistant Hypertension

DrugBosentan

University Hospital, Rouen

Phase 2

Rouen

2021-10-20

Recruiting

Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients

NCT04694534Multiple Sclerosis, Memory, Learning

Lille Catholic University

Not applicable

150

Arras, Lens, Lille, Lomme, Rouen

2021-10-08

Active, closed

A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate

NCT04909801Rheumatoid Arthritis

DrugsAbatacept·Humira·Adalimumab·Methotrexate

Bristol-Myers Squibb

Phase 3

338

Montpellier, Rouen, Strasbourg, Toulouse

2021-09-15

Active, closed

Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033)

NCT04776252HIV-1 Infection

DrugDOR/ISL

Merck Sharp & Dohme LLC

Phase 3

2,000

Nice, Dijon, Bordeaux, Toulouse, Rouen, Montpellier, Nantes, Tourcoing

2021-09-15

Active, closed

Safety, Tolerability, Pharmacokinetics and Efficacy Study of Radotinib in Parkinson's Disease

NCT04691661Parkinson Disease

DrugRadotinib HCl

Il-Yang Pharm. Co., Ltd.

Phase 2

Lille, Limoges, Lyon, Nantes, Paris, Poitiers, Rouen

2021-09-09

Recruiting

Frequency of Palpebral Involvement in Adult With Atopic Dermatitis

NCT04826744Atopic Dermatitis

University Hospital, Lille

Observational

550

Lille, Rouen

2021-09-01

Recruiting

Lung Cancer Screening in a Population Exposed to Occupational Lung Carcinogens

NCT03562052Lung Cancer

Centre Hospitalier Intercommunal Creteil

Observational

6,000

Bordeaux, Brest, Caen, Créteil, Rennes, Rouen, Toulon

2021-07-22

Recruiting

A Case Management Algorithm for Women Victims of Violence

NCT04953273Post-Traumatic Stress Disorder, Violence-Related Symptom

University Hospital, Lille

Not applicable

756

Amiens, Boulogne-sur-Mer, Caen, Creil, Lille, Rouen, Saint-Quentin, Valenciennes

2021-07-06

Recruiting

Interest of Bilateral Basic Tongue Mucosectomy Assisted by Robot or Laser in Combination with Tonsillectomy in the Assessment of Prevalent Cervical Lymphadenopathy

NCT04767048Cancer of Head and Neck, Adenopathy

Centre Francois Baclesse

Phase 2

Caen, Lille, Rouen

2021-06-30

Active, closed

Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease

NCT04915755Neoplasms, Breast

DrugNiraparib

GlaxoSmithKline

Phase 3

Avignon, Bordeaux, Caen, Dijon, Marseille, Montpellier, Pierre-Bénite, Rouen

2021-06-28

Active, closed

PET TDM FDG-Choline as a Decision-making Tool for Routine Care on the Liver Transplant List for HCC

NCT04792801Hepatocellular Carcinoma, Liver Transplant

University Hospital, Lille

Observational

108

Lille, Rouen

2021-06-22

Recruiting

Dimensional and Developmental Profiles of Psychosis in Children and Adolescents

NCT04370730Schizophrenia, Psychotic Disorders

Assistance Publique - Hôpitaux de Paris

Not applicable

200

Gentilly, Lille, Nice, Paris, Rouen

2021-06-02

Active, closed

The SELUTION DeNovo Study

NCT04859985Coronary Artery Disease

M.A. Med Alliance S.A.

Not applicable

3,326

La Rochelle, Massy, Nîmes, Paris, Pau, Rouen

2021-05-15

Active, closed

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Ribociclib·Abemaciclib·Palbociclib

AstraZeneca

Phase 3

893

Bobigny, Limoges, Lyon, Plérin, Rouen, Saint-Herblain, Villejuif

2021-05-10

Recruiting

Diagnostic Yield of Post PRandial Esophageal High Resolution Impedance Manometry in Patients With Gastro-Esophageal Reflux Disease Symptoms Resistant to Proton Pump Inhibitor Therapy

NCT03596476Gastro-esophageal Reflux Disease

Hospices Civils de Lyon

Not applicable

330

Chambray-lès-Tours, Colombes, Lyon, Nantes, Pessac, Rennes, Rouen

2021-05-03

Recruiting

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

NCT04752722Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Non-muscle Invasive Bladder Cancer

DrugPhase 2

enGene, Inc.

Phase 1/2

350

Angers, Bordeaux, Lille, Lyon, Paris, Rouen

2021-04-22

Active, closed

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

NCT04662255Lymphoma, Mantle-Cell

DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib

Loxo Oncology, Inc.

Phase 3

500

Bordeaux, Paris, Lille, Vandœuvre-lès-Nancy, Politiers, Rouen, Nantes, Pessac

2021-04-08

Active, closed

Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

NCT04586023Relapsing Multiple Sclerosis

DrugsFenebrutinib·Teriflunomide

Hoffmann-La Roche

Phase 3

751

Clermont-Ferrand, Nice, Rouen, Toulouse

2021-03-24

Recruiting

Circulating Tumor DNA in Primary Mediastinal Large B-cell Lymphoma (PMBL)

NCT04824950Primary Mediastinal Large B-cell Lymphoma

Centre Henri Becquerel

Not applicable

Lyon, Rouen

2021-03-22

Active, closed

Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT04666038Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsIdelalisib·Truxima·Pirtobrutinib·Bendamustine

Loxo Oncology, Inc.

Phase 3

238

Grenoble, Bobigny, Pierre-Bénite, La Roche-sur-Yon, Nîmes, Politiers, Rouen, Tours

2021-03-09

Recruiting

A Pilot Study for Systematic Neonatal Screening for Lysosomal Storage Diseases Using Tandem Mass Spectrometry

NCT04393701Neonatal Screening, Lysosomal Storage Diseases

University Hospital, Rouen

Observational

100,000

Caen, Rouen

2021-03-08

Recruiting

LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients

NCT04768322End-stage Heart Failure

Hospices Civils de Lyon

Not applicable

Besançon, Bron, Caen, La Tronche, Montpellier, Rouen, Tours, Vandœuvre-lès-Nancy

2021-02-24

Recruiting

Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL

NCT04502394Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma

DrugsNavtemadlin·Acalabrutinib

Kartos Therapeutics, Inc.

Phase 1/2

Nantes, Rouen, Tours

2021-02-23

Active, closed

A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

NCT04204616Prurigo Nodularis

DrugNemolizumab

Galderma R&D

Phase 3

500

Bordeaux, Brest, Nantes, Nice, Paris, Pierre-Bénite, Rouen, Saint-Etienne

2021-01-11

Active, closed

Assessment of the Axone Micro Quadripolar Lead for Enhanced Cardiac Resynchronization Therapy

NCT04463641Heart Failure, Cardiac Resynchronization Therapy

MicroPort CRM

Not applicable

Annecy, Chambray-lès-Tours, Clermont-Ferrand, Grenoble, Lille, Rennes, Rouen, Toulouse

2020-12-03

Active, closed

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

NCT04544436Multiple Sclerosis

DrugsOcrelizumab·Methylprednisolone

Hoffmann-La Roche

Phase 3

864

Bordeaux, Clermont-Ferrand, Lille, Rouen

2020-11-26

Recruiting

Optimised Early Management of Squamous Cell Carcinoma of the Head and Neck Cancer

NCT04528420Squamous Cell Carcinoma of Head and Neck

Centre Henri Becquerel

Not applicable

138

Amiens, Beauvais, Caen, Le Havre, Lille, Rouen, Saint-Quentin

2020-11-26

Active, closed

Root Canal Obturation With a Ready-to-use Root Canal Sealer (PA1704) Versus BioRoot™ RCS: a Randomized Controlled Trial

NCT04757753Root Canal Obturation

Septodont

Not applicable

160

Paris, Rennes, Rouen, Saint-Grégoire

2020-11-06

Active, closed

Interest of Morphokinetic Parameters of Early Embryonic Development in the Birth Rates in Vitro Fertilization

NCT03806153Reproductive Disorder

University Hospital, Rouen

Not applicable

520

Caen, Rouen

2020-10-26

Active, closed

Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC

NCT04550260Esophageal Squamous Cell Carcinoma

DrugsFluorouracil·Durvalumab·Capecitabine·Cisplatin

AstraZeneca

Phase 3

640

Besançon, Lille, Lyon, Montpellier, Reims, Rouen, Strasbourg, Villejuif

2020-10-19

Recruiting

Functional Digestive Disorders Observatory

NCT04918329Irritable Bowel Syndrome, Dyspepsia, Functional Constipation, Faecal Incontinence

University Hospital, Rouen

Observational

2,000

Rouen

2020-10-09

Recruiting

Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)

NCT04558450Covid19, Arterial Stiffness, Endothelial Dysfunction, Diastolic Dysfunction

Assistance Publique - Hôpitaux de Paris

Not applicable

360

Nancy, Paris, Rouen

2020-09-21

Active, closed

Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

NCT04384484Relapsed Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma

DrugsLoncastuximab Tesirine·Rituximab·Oxaliplatin·Gemcitabine

ADC Therapeutics S.A.

Phase 3

440

Brest, Bobigny, Dijon, Nantes, Paris, Pessac, Rouen

2020-09-16

Recruiting

Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study

NCT04471129Chronic Heart Failure

University Hospital, Rouen

Not applicable

Rouen

2020-09-16

Active, closed

Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients)

NCT01817192Non-Small Cell Lung Cancer

Razor Genomics

Not applicable

420

Bordeaux, Rouen, Angers, Bayonne, Besançon, Boulogne, Clamart, Créteil

2020-09-11

Active, closed

Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome

NCT04401748Myelodysplastic Syndrome (MDS)

DrugsVenclexta·Azacitidine·Venetoclax

AbbVie

Phase 3

531

Nice, Pessac, La Tronche, Lille, Nantes, Marseille, Rouen, Avignon

2020-09-10

Active, closed

SELUTION SLR™ 014 In-stent Restenosis

NCT04280029Coronary Restenosis

M.A. Med Alliance S.A.

Not applicable

418

Dijon, Massy, Rouen, Toulouse

2020-07-06

Recruiting

A Brain Metastases Research Platform to Tackle the Challenge of CNS Metastases in Solid Tumours

NCT04109131CNS Metastases

Jules Bordet Institute

Not applicable

600

Lille, Marseille, Paris, Rouen, Strasbourg, Toulouse

2020-07-01

Active, closed

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma

DrugTazemetostat

Epizyme, Inc.

Phase 3

599

Pessac, Brest, Bordeaux, Mulhouse, Rouen, Limoges, La Tronche, Nantes

2020-06-11

Recruiting

Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism

NCT04263038Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases

DrugRivaroxaban

Drahomir Aujesky

Phase 4

276

Le Kremlin-Bicêtre, Brest, Clermont-Ferrand, Dijon, Lyon, Marseille, Rouen, Saint-Priest-en-Jarez

2020-05-15

Active, closed

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer

NCT04305496Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Fulvestrant

AstraZeneca

Phase 3

818

Besançon, Brest, Metz, Pierre-Bénite, Plerin SUR MER, Pringy, Rouen, Strasbourg

2020-04-16

Recruiting

High Resolution Imaging for Analysis of MVNT

NCT04285125Benign Neuronal Desease

Fondation Ophtalmologique Adolphe de Rothschild

Observational

Bordeaux, Rennes, Rouen, Toulouse, Paris, Pierre-Bénite, Saint-Herblain

2020-03-05

Recruiting

A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.

NCT04116541Malignant Solid Tumor

DrugsSiremadlin·Avapritinib·Alectinib·Dabrafenib

Centre Leon Berard

Phase 2

455

Angers, Bordeaux, Caen, Lyon, Marseille, Nice, Paris, Rouen

2020-01-28

Recruiting

Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study

NCT03582800Systemic Sclerosis, Dermatomyositis, iPPSD2

University Hospital, Limoges

Phase 2

Bordeaux, Bron, Le Kremlin-Bicêtre, Limoges, Paris, Rennes, Rouen, Toulouse

2020-01-06

Active, closed

Effectiveness and Tolerability of Eqwilate in Real-life Conditions

NCT04106908VWD - Von Willebrand's Disease

Octapharma

Observational

Caen, Clamart, Paris, Rennes, Rouen, Saint-Denis, Saint-Etienne

2019-11-27

Recruiting

Cohort for Monitoring Patients With Venous Thromboembolic Disease

NCT07016542Venous Thromboembolic Disease

University Hospital, Rouen

Observational

2,000

Rouen

2019-11-18

Active, closed

A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

NCT04025879Carcinoma, Non-Small-Cell Lung

DrugsOpdivo·Pemetrexed·Docetaxel·Nivolumab

Bristol-Myers Squibb

Phase 3

461

Besançon, La Tronche, Montpellier, Paris, Rennes, Rouen

2019-11-05

Recruiting

Follow-up Cohort of Patients With Antiphospholipid Syndrome

NCT07178925Antiphospholipid Syndrome (APS)

University Hospital, Rouen

Observational

200

Rouen

2019-10-16

By invitation

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

NCT03683186PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension

United Therapeutics

Phase 3

1,000

Strasbourg, Grenoble, Vandœuvre-lès-Nancy, Saint-Étienne-de-Montluc, Bron, Rouen, Le Kremlin-Bicêtre, Besançon

2019-09-23

Active, closed

Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients.

NCT04053322ER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancer, a Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI Status

DrugsOlaparib·Fulvestrant·Durvalumab

UNICANCER

Phase 2

172

Montpellier, Rouen

2019-08-26

Active, closed

Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)

NCT03992417Dermatitis Atopic

DrugDupilumab

Sanofi

Observational

955

2019-06-11

Active, closed

A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)

NCT03930953Lymphoma, Non-Hodgkin

DrugsValemetostat·Tafasitamab·Golcadomide·Obinutuzumab

Celgene

Phase 1/2

438

Bordeaux, Créteil, Lille, Montpellier, Paris, Pierre-Bénite, Rouen, Toulouse

2019-05-20

Active, closed

A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer

NCT03816163Pancreatic Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma

DrugsZolbetuximab·Nab-paclitaxel·Gemcitabine

Astellas Pharma Global Development, Inc.

Phase 2

393

Besançon, Brest, Caen, Chambray, Herblain, La Chaussée-Saint-Victor, Nancy, Rouen

2019-03-15

Active, closed

Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

NCT03836261Chronic Lymphocytic Leukemia

DrugsAcalabrutinib·Venclexta·Obinutuzumab·Venetoclax

Acerta Pharma BV

Phase 3

984

Montpellier, Paris, Rennes, Rouen, Toulouse, Villejuif

2019-02-25

Recruiting

Understanding the Long-Term Management of Organic Acidemia Patients With CARBAGLU®: A Mixed Methods Approach

NCT04176523Methylmalonic Acidemia, Propionic Acidemia

DrugCarglumic Acid

RECORDATI GROUP

Observational

Bordeaux, Marseille, Nancy, Paris, Rouen, Strasbourg

2019-01-15

Active, closed

Paclitaxel + Carboplatin + Durvalumab With or Without Oleclumab for Previously Untreated Locally Recurrent Inoperable or Metastatic TNBC

NCT03616886Triple Negative Breast Cancer

DrugsOleclumab·Durvalumab·Paclitaxel·Carboplatin

Jules Bordet Institute

Phase 1/2

129

Besançon, Bordeaux, Dijon, Marseille, Nice, Paris, Poitiers, Rouen

2018-12-28

Active, closed

Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC

NCT03732677Muscle Invasive Bladder Cancer

DrugsDurvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,063

Angers, Dijon, Grenoble, Montpellier, Nîmes, Pierre-Bénite, Poitiers, Rouen

2018-11-16

Active, closed

A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.

NCT03539744Multiple Myeloma

DrugsPomalidomide·Venetoclax·Dexamethasone

AbbVie

Phase 3

265

La Tronche, Reims, Vandœuvre-lès-Nancy, Lille, Créteil, Nantes, Pierre-Bénite, Rouen

2018-10-22

Recruiting

Clinical Evaluation of Laryngeal Transplantation: Study of 3 Patients

NCT02821299Laryngeal Transplantation

Hospices Civils de Lyon

Not applicable

Lyon, Rouen, Saint-Didier-au-Mont-d'Or

2018-09-20

Active, closed

Study of Immunotherapy in Combination With Chemotherapy in HER2-negative Inflammatory Breast Cancer

NCT03515798Inflammatory Breast Cancer

DrugPembrolizumab

Institut Paoli-Calmettes

Phase 2

Amiens, Avignon, Bordeaux, Caen, Dijon, Lyon, Paris, Rouen

2018-08-29

Active, closed

Study on Aspirin Versus Placebo in Resected Colon Cancer With PI3K Mutation Stage III or II High Risk

NCT02945033Colorectal Cancer

University Hospital, Rouen

Phase 3

264

Rouen

2018-07-12

Active, closed

First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma

NCT03625037DLBCL, High-grade B-cell Lymphoma (HGBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), FL

DrugEpcoritamab

Genmab

Phase 1/2

666

Créteil, Montpellier, Paris, Pierre-Bénite, Rouen, Tours

2018-06-26

Active, closed

Safety and Efficacy Study of USTRAP™ in Male Urinary Incontinence

NCT03323554Urinary Incontinence

Quanta Medical

Not applicable

Rouen

2018-06-01

Recruiting

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

NCT03526835Advanced/Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Gastroesophageal-junction Cancer

DrugPetosemtamab

Merus B.V.

Phase 1/2

560

Bordeaux, Lyon, Marseille, Montpellier, Nice, Paris, Rouen

2018-05-02

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

NCT03425643Non-small Cell Lung Cancer

DrugsPemetrexed·Keytruda·Gemcitabine·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

797

Suresnes, Pierre-Bénite, Strasbourg, Toulouse, Limoges, Chambéry, Pringy, Rouen

2018-04-24

Active, closed

Observatory of Patients With Metastatic ProstAte Adenocarcinoma That is Resistant to Castration and Multi-LinE Strategies

NCT03611686Metastatic Prostate Adenocarcinoma

University Hospital, Rouen

Observational

219

Rouen

2018-04-17

Active, closed

Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling

NCT03411317Aortic Valve Stenosis

University Hospital, Rouen

Observational

350

Rouen

2017-12-11

Active, closed

Aortic Stenosis: Determinants and Prognostic Value of Preoperative Left Ventricular Remodeling After Valvular Replacement

NCT03411304Aortic Valve Stenosis

University Hospital, Rouen

Observational

440

Rouen

2017-12-05

Active, closed

Assessment of Safety and Performances of HYPE Stems Associated to a SERF Acetabular Cup in Hip Arthroplasty (2017-01-NH)

NCT05524350Hip Arthropathy

Societe dEtude, de Recherche et de Fabrication

Observational

180

Rouen

2017-12-05

Active, closed

Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.

NCT03229200Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Leukemia, B-cell, Graft Vs Host Disease

DrugIbrutinib

Pharmacyclics Switzerland GmbH

Phase 4

297

Nantes, Rouen, Saint-Brieuc

2017-05-22

Active, closed

LEADERS FREE II: BioFreedom™ Pivotal Study

NCT02843633Acute Coronary Syndrome, High Bleeding Risk

Biosensors Europe SA

Not applicable

1,203

Aix-en-Provence, Clermont-Ferrand, Fontaine-lès-Dijon, Grenoble, Massy, Quincy-sous-Sénart, Rouen, Toulouse

2017-02-14

Recruiting

In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions

NCT03371641Fetal Alcohol Syndrome

University Hospital, Rouen

Not applicable

Rouen

2017-01-27

Recruiting

Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility

NCT02948972Endometriosis, Infertility

University Hospital, Lille

Not applicable

120

Clermont-Ferrand, Lille, Paris, Poissy, Rouen

2016-11-17

Active, closed

Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

NCT02477696Chronic Lymphocytic Leukemia

DrugsIbrutinib·Acalabrutinib

Acerta Pharma BV

Phase 3

533

Bobigny, Créteil, Pierre-Bénite, Rennes, Rouen, Toulouse

2015-07-28

Active, closed

Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas

NCT02503423Solid Tumors, Lymphoma

DrugTolinapant

Taiho Oncology, Inc.

Phase 1/2

253

Villejuif, Pierre-Bénite, Bordeaux, Nice, Rouen, Toulouse, Tours

2015-07-14

Active, closed

A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial

NCT02320435Solid Tumors

DrugsPerjeta·Pertuzumab·Trastuzumab

Hoffmann-La Roche

Phase 3

154

Dijon, Rouen, Saint-Brieuc, Saint-Cloud

2015-02-02

Active, closed

Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy

NCT02872571Disorder of Endocrine Pancreas

University Hospital, Lille

Phase 1/2

Amiens, Lille, Marseille, Rouen

2013-03

Active, closed

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

NCT01760005Alzheimers Disease, Dementia, Alzheimers Disease, Familial

DrugsE2814·Lecanemab

Washington University School of Medicine

Phase 2/3

490

Toulouse, Lille, Paris, Bron, Rouen

2012-12

Active, closed

Impact of Weight Loss Induced by Bariatric Surgery or Nutritional Management on Sexual Function in Men With Severe Obesity

NCT03528980Obesity, Bariatric Surgery Candidate

University Hospital, Lille

Observational

Caen, Lille, Rouen

2012-05-21

Recruiting

Registry of Myelodysplastic Syndromes and Therapy-related Acute Myeloid Leukemia

NCT06956755Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

Groupe Francophone des Myelodysplasies

Observational

6,990

Rouen

2003-07-07

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a French investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 28 October 2026. https://priyalifescience.com/clinical-trials-france/city/rouen

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in France and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,697 studies in total at the last sync on 26 Oct 2026, 03:20 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 384 of those studies with a site in Rouen.

How many clinical trials are recruiting in Rouen?

216 of the 384 studies on this page are recruiting new participants as of the 26 Oct 2026, 03:20 UTC sync. A further 54 have not yet opened recruitment, 110 are active but closed to new participants, and 4 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Rouen), 384 studies
Phase	Studies	Recruiting	Share
Not applicable	126	81	32.8%
Phase 3	103	45	26.8%
Observational	82	49	21.4%
Phase 2	39	25	10.2%
Phase 2/3	12	7	3.1%
Phase 1/2	10	3	2.6%
Phase 4	9	4	2.3%
Phase 1	3	2	0.8%

Most active sponsors

Lead sponsors with the most studies (Rouen)
Lead sponsor	Studies	Recruiting
University Hospital, Rouen	92	57
Centre Henri Becquerel	22	12
AstraZeneca	14	5
Merck Sharp & Dohme LLC	10	5
Hoffmann-La Roche	9	1
ADIR Association	8	4
Novartis Pharmaceuticals	8	5
University Hospital, Lille	8	5
Assistance Publique - Hôpitaux de Paris	7	4
Centre Francois Baclesse	6	5

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.