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Clinical Trials in France / NCT05161026
Starting soon Not applicable

Impact of Allo-HSCT on Bone Remodeling: Evolution of Bone Mineral Density and Architecture Measured by Bone Densitometry

NCT05161026 · tracked via the Priya Life Science France tracker
Phase
Not applicable
Started
2021-12-10
Last updated
2021-12-16

Condition(s) studied

Myeloid Leukemia, Acute

Investigational drug(s) / intervention(s)

Bone osteodensitometry

Bone osteodensitometry: Evaluation of bone osteodensitometry

Study summary

Evaluation of variation of mineral density and bone microarchitecture after allogeneic HSCTs transplant in hematologic malignancies. Comparison with the general population.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * Cytological diagnosis of acute myeloid leukemia (AML) with indication for a first-line allo-HSCTs transplant * Patient affiliated to the social security system * For women of childbearing age, use of reliable contraception throughout the study in accordance with the CPR of the drugs used. * The patient must be able to comply with study visits and per protocol procedures * Patient who has been informed of the study and has signed his informed consent Exclusion Criteria: * Person under guardianship or curatorship, or unable to understand the purpose of the study. * Hematologic malignancies other than AML * History of neoplasia with bone involvement (sarcoma, multiple myeloma, metastasis...) and/or any solid cancer less than 5 years old * History of fracture of the femoral neck prior to the diagnosis of hematologic malignancies * Known bone involvement related to AML at diagnosis * Primary or secondary osteoporosis known to the diagnosis of hematologic malignancies * Corticotherapy \> 3 months at a dose \> 7.5mg/day prior to the diagnosis of hematological disease * Autograft or anterior allograft * Pathologies influencing bone metabolism: known inflammatory rheumatism (rheumatoid arthritis, ...), primary hyperparathyroidism, chronic renal failure (GFR \< or = at 30ml / min / 1.73m2) * Pregnant or lactating woman

Primary outcome measure(s)

Trial sites (4)

FacilityCityRegionStatus
Chu Amiens Amiens France
CHU CAEN Caen France
Chu Lille Lille France
Chu Rouen Rouen France

More University Hospital, Caen trials in France

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05161026 on ClinicalTrials.gov ↗ ← All trials in France