Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide
Priya Life Science Clinical trial register
TrackersDrugsComparisonsAPI
Trackers› Clinical trials› Connecticut
Clinical trial register · United States · industry-sponsored

Clinical Trials in Connecticut, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

Download CSV
Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Eli Lilly and Company58 AstraZeneca58 AbbVie48 Merck Sharp & Dohme LLC39 Janssen Research & Development, LLC39
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Connecticut

1273 of 9118 studies
Download
Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer
NCT04676477Non-Small Cell Lung Cancer (NSCLC)
DrugsPatritumab deruxtecan·Osimertinib
Daiichi Sankyo
Phase 1
246
California, Connecticut, District of Columbia, Illinois, Massachusetts, Michigan, New Hampshire, New York
2021-06-11
Active, closed
An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
NCT04720157Prostatic Neoplasms
DrugsARDT·Illuccix·Lu-PSMA
Novartis Pharmaceuticals
Phase 3
1,140
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Hawaii
2021-06-09
Active, closed
FSL2 Post Approval Study for Pediatric and Young Adults Patients
NCT04959552Diabete Mellitus
Abbott Diabetes Care
Observational
550
Connecticut, Missouri, Nevada
2021-06-01
Recruiting
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
NCT04844606Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
DrugMirikizumab
Eli Lilly and Company
Phase 3
150
California, Connecticut, Georgia, Massachusetts, Missouri, New York, Pennsylvania, Texas
2021-05-26
Recruiting
DALY II USA/ MB-CART2019.1 for DLBCL
NCT04792489Refractory Diffuse Large B Cell Lymphoma (DLBCL), Relapsed Diffuse Large B Cell Lymphoma, High Grade B-cell Lymphoma (HGBCL), Primary Mediastinal B-cell Lymphoma (PMBCL)
DrugsZamtocabtagene autoleucel·Bendamustine·Fludarabine·Cyclophosphamide
Miltenyi Biomedicine GmbH
Phase 2
315
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2021-05-25
Active, closed
Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
NCT04544293Autoimmune Pulmonary Alveolar Proteinosis
DrugMolgramostim
Savara Inc.
Phase 3
164
Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Maryland
2021-05-19
Active, closed
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
NCT04821622Prostate Cancer
DrugsTalazoparib·Enzalutamide
Pfizer
Phase 3
599
Alabama, Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Illinois
2021-05-12
Active, closed
Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer
DrugsCapivasertib·Abemaciclib·Ribociclib·Palbociclib
AstraZeneca
Phase 3
893
Arizona, California, Colorado, Connecticut, Delaware, Kentucky, Maryland, Massachusetts
2021-05-10
By invitation
Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM
NCT04848506Symptomatic Hypertrophic Cardiomyopathy (HCM)
DrugAficamten
Cytokinetics
Phase 2/3
900
Alabama, Alaska, Arizona, California, Connecticut, District of Columbia, Florida, Georgia
2021-05-06
Active, closed
A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
NCT04777331Parkinsons Disease
DrugPrasinezumab
Hoffmann-La Roche
Phase 2
586
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Kansas
2021-05-05
Active, closed
A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)
NCT04853576Sickle Cell Disease, Hemoglobinopathies
Editas Medicine, Inc.
Phase 1/2
45
California, Colorado, Connecticut, Florida, Georgia, Illinois, Mississippi, New Jersey
2021-05-04
Recruiting
Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors
NCT04855656Advanced Solid Tumor
DrugsCamonsertib·Lunresertib
Debiopharm International SA
Phase 1
464
California, Connecticut, Florida, Massachusetts, Michigan, Minnesota, Missouri, New York
2021-04-30
Recruiting
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
NCT04743141Acute Treatment of Migraine
DrugRimegepant
Pfizer
Phase 3
600
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2021-04-28
Active, closed
A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.
NCT04680052Follicular Lymphoma, Marginal Zone Lymphoma
DrugsTafasitamab·Lenalidomide·Rituximab
Incyte Corporation
Phase 3
654
California, Connecticut, Florida, Georgia, Hawaii, Iowa, Kentucky, Louisiana
2021-04-15
Active, closed
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
NCT04736706Carcinoma, Renal Cell
DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda
Merck Sharp & Dohme LLC
Phase 3
1,688
Alabama, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2021-04-14
Active, closed
Eversense® Non-adjunctive Use Post Approval Study
NCT04836546Diabetes
Senseonics, Inc.
Not applicable
925
California, Colorado, Connecticut, Florida, Georgia, Idaho, Illinois, Louisiana
2021-04-13
Active, closed
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
NCT04763200Left Ventricular Dysfunction, Coronary Artery Disease
Abiomed Inc.
Not applicable
1,252
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2021-04-13
Active, closed
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
NCT04576156Myelofibrosis
DrugImetelstat Sodium
Geron Corporation
Phase 3
327
California, Connecticut, Florida, Kentucky, New York, North Carolina, Ohio, South Dakota
2021-04-12
Active, closed
Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
DrugsPelabresib·Ruxolitinib
Novartis Pharmaceuticals
Phase 3
430
Alabama, Arizona, California, Connecticut, Florida, Illinois, Indiana, Kentucky
2021-04-09
Active, closed
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
NCT04722250Symptomatic Aortic Stenosis, Aortic Valve Stenosis, Aortic Valve Replacement
Medtronic Cardiovascular
Not applicable
1,103
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana
2021-04-02
Active, closed
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181Non-alcoholic Steatohepatitis
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,205
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2021-04-01
Recruiting
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
NCT04674969Peripheral Vascular Diseases
Boston Scientific Corporation
Observational
5,000
Arkansas, California, Connecticut, Delaware, District of Columbia, Florida, Georgia, Illinois
2021-03-29
Recruiting
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564Motor Function, Cognitive Function, Contrast Media
DrugsGadavist·Gadoterate meglumine·Gadobutrol
Guerbet
Phase 4
2,076
Arizona, Connecticut, Illinois, Massachusetts, Missouri, North Carolina, Pennsylvania, Texas
2021-03-24
Active, closed
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
NCT04591392Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities
atHeart Medical
Not applicable
250
Alabama, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2021-03-12
Active, closed
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
NCT04562389Myelofibrosis
DrugsSelinexor·Ruxolitinib
Karyopharm Therapeutics Inc
Phase 3
353
Alabama, California, Colorado, Connecticut, District of Columbia, Kentucky, Maryland, Michigan
2021-03-11
Recruiting
Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors
NCT04777994Advanced Solid Tumor Cancer
Calico Life Sciences LLC
Phase 1
248
Arizona, Connecticut, Maryland, Massachusetts, Michigan, New York, North Carolina, Pennsylvania
2021-03-09
Active, closed
A Clinical Trial Comparing the BAGUERA C to the Marketed Mobi-C® for the Treatment of Cervical Disc Disease at 2 Contiguous Levels
NCT04564885Cervical Disc Disease
Spineart USA
Not applicable
300
Arizona, California, Colorado, Connecticut, District of Columbia, Georgia, Illinois, Indiana
2021-03-02
Active, closed
Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
NCT04696731Advanced/Metastatic Clear Cell Renal Cell Carcinoma
DrugsALLO-647·Fludarabine·Cyclophosphamide
Allogene Therapeutics
Phase 1
120
California, Connecticut, District of Columbia, Florida, Michigan, New York, Oregon, Texas
2021-02-24
Recruiting
Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old
NCT04748601Migraine Disorders
Upsher-Smith Laboratories
Phase 4
132
Alabama, California, Colorado, Connecticut, Florida, Michigan, Mississippi, Missouri
2021-02-19
Active, closed
Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
NCT04562532Coronary Artery Disease
Shanghai MicroPort Medical (Group) Co., Ltd.
Not applicable
1,720
Alabama, Arizona, California, Connecticut, Florida, Georgia, Indiana, Kansas
2021-02-17
Active, closed
Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML)
NCT04657081Acute Myeloid Leukemia
DrugsDecitabine·Venclexta·Venetoclax
Taiho Oncology, Inc.
Phase 1/2
101
California, Connecticut, Florida, Illinois, Indiana, Massachusetts, Missouri, New Jersey
2021-02-09
Active, closed
DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE)
NCT04567420Breast Cancer
DrugsPalbociclib·Fulvestrant
Criterium, Inc.
Phase 2
70
Arizona, California, Colorado, Connecticut, Georgia, Louisiana, Nebraska, New Mexico
2021-02-09
Active, closed
Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
NCT04755283Atrial Fibrillation (AF), Stroke
DrugsAbelacimab·Rivaroxaban
Anthos Therapeutics, Inc.
Phase 2
1,287
Alabama, Connecticut, Florida, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2021-02-02
Active, closed
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
NCT04624659Sickle Cell Disease
DrugEtavopivat
Forma Therapeutics, Inc.
Phase 3
450
Alabama, Arizona, Arkansas, California, Connecticut, District of Columbia, Florida, Georgia
2021-01-29
Recruiting
OssiMend BA in Posterolateral Instrumented Lumbar Fusion
NCT04775537Spinal Disease, Degenerative Disc Disease
Collagen Matrix
Observational
120
California, Connecticut, New Jersey, Oregon
2021-01-21
Active, closed
Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784Abdominal Aortic Aneurysm
Bolton Medical
Not applicable
338
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Iowa
2021-01-20
Recruiting
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
NCT04649242Pediatric Migraine
Pfizer
Phase 3
2,100
Alabama, Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida
2021-01-15
Active, closed
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis
NCT04539964Rheumatoid Arthritis
DrugConventional Synthetic DMARD
SetPoint Medical Corporation
Phase 3
243
Arizona, California, Colorado, Connecticut, Delaware, Florida, Georgia, Illinois
2021-01-11
Active, closed
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
NCT04634877Endometrial Neoplasms
DrugsDocetaxel·Keytruda·Paclitaxel·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
990
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2021-01-10
Active, closed
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
NCT04534205Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
DrugPembrolizumab
BioNTech SE
Phase 2/3
358
California, Connecticut, District of Columbia, Florida, Georgia, Kentucky, Massachusetts, New Mexico
2021-01-07
Active, closed
Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD
NCT04704921AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
DrugsLucentis·Ranibizumab
AbbVie
Phase 2/3
671
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2020-12-29
Active, closed
A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation
NCT04625270Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer
DrugsAvutometinib (VS-6766) and defactinib·Avutometinib·Lumakras
Verastem, Inc.
Phase 2
225
Arizona, California, Connecticut, Florida, Illinois, Maryland, Minnesota, Missouri
2020-12-21
Active, closed
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
NCT04171492Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Biodesix, Inc.
Observational
2,000
Colorado, Connecticut, District of Columbia, Indiana, Maryland, Michigan, Minnesota, Missouri
2020-12-18
Active, closed
Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy
NCT04655976Lung Cancer, Non-Small Cell
DrugsCobolimab·Dostarlimab·Docetaxel
GlaxoSmithKline
Phase 2/3
758
California, Connecticut, District of Columbia, Hawaii, Iowa, Kentucky, Nevada, New York
2020-12-08
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
DrugsAdagrasib·Pembrolizumab
Mirati Therapeutics Inc.
Phase 2/3
626
Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2020-12-02
Active, closed
FS120 Phase 1/1b Study in Patients With Advanced Malignancies
NCT04648202Advanced Cancer, Metastatic Cancer
invoX Pharma Limited
Phase 1
82
Connecticut, Texas, Utah
2020-11-18
Active, closed
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
NCT04499248Open-angle Glaucoma, Ocular Hypertension
AbbVie
Phase 1/2
100
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts
2020-11-16
Recruiting
Study of PF-07248144 in Advanced or Metastatic Solid Tumors
NCT04606446Locally Advanced or Metastatic ER+ HER2- Breast Cancer, Locally Advanced or Metastatic Castration-resistant Prostate Cancer, Locally Advanced or Metastatic Non-small Cell Lung Cancer
DrugsPrifetrastat·Atirmociclib·Palbociclib·Letrozole
Pfizer
Phase 2
320
Arizona, California, Connecticut, Florida, Kentucky, Tennessee, Texas, Washington
2020-11-16
Active, closed
IN.PACT™ AV Access Post-Approval Study (PAS002)
NCT04543539Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Fistula
Medtronic
Observational
240
California, Connecticut, District of Columbia, Florida, Iowa, Michigan, Minnesota, New Jersey
2020-11-13
Recruiting
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
NCT04302025Non-small Cell Lung Cancer
DrugsCobimetinib·Pralsetinib·Divarasib·SBRT
Genentech, Inc.
Phase 2
99
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Massachusetts, Michigan
2020-11-06
Active, closed
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
NCT04301518Preterm Labor, Preterm Birth
Sera Prognostics, Inc.
Not applicable
6,500
California, Connecticut, Delaware, Florida, Kentucky, Louisiana, Massachusetts, Michigan
2020-11-06
Active, closed
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)
NCT04524871Advanced Liver Cancers
DrugsADG126·Tobemstomig·Tiragolumab·Tocilizumab
Hoffmann-La Roche
Phase 1/2
518
California, Colorado, Connecticut, District of Columbia, Kentucky, Oregon, Tennessee, Texas
2020-11-01
Recruiting
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor
DrugsRezatapopt·Keytruda·Pembrolizumab
PMV Pharmaceuticals, Inc
Phase 1/2
300
California, Colorado, Connecticut, Delaware, Florida, Massachusetts, Michigan, New York
2020-10-29
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
NCT04544449Multiple Sclerosis, Primary Progressive
DrugsFenebrutinib·Ocrelizumab
Hoffmann-La Roche
Phase 3
985
Alabama, California, Colorado, Connecticut, District of Columbia, Florida, Indiana, Kansas
2020-10-26
Recruiting
NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness
NCT04471909Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
Endospan Ltd.
Not applicable
110
Alabama, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2020-10-20
Active, closed
TTVR Early Feasibility Study
NCT04433065Tricuspid Regurgitation
Medtronic Cardiovascular
Not applicable
150
Alabama, Arizona, California, Connecticut, Georgia, Michigan, Minnesota, Montana
2020-10-20
Active, closed
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
NCT04446117Metastatic Prostate Cancer, Prostate Adenocarcinoma
DrugsZytiga·Xtandi·Abiraterone·Abiraterone acetate
Exelixis
Phase 3
575
Arizona, California, Colorado, Connecticut, Florida, Georgia, Kansas, Kentucky
2020-10-19
Active, closed
Myasthenia Gravis Inebilizumab Trial
NCT04524273Myasthenia Gravis
DrugInebilizumab
Amgen
Phase 3
238
California, Connecticut, District of Columbia, Florida, Kansas, North Carolina, Ohio, Pennsylvania
2020-10-15
Active, closed
CHAMPION-AF Clinical Trial
NCT04394546Atrial Fibrillation, Stroke, Bleeding
DrugsNon-Vitamin K Anticoagulant·NOAC
Boston Scientific Corporation
Not applicable
3,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia
2020-10-15
Active, closed
CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC
NCT04495153Non Small Cell Lung Cancer
DrugAglatimagene besadenovec
Candel Therapeutics, Inc.
Phase 2
90
Arizona, Connecticut, Illinois, Maryland, Minnesota, New York, Ohio, Pennsylvania
2020-10-13
Active, closed
A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults
NCT04584710Covid19
DrugDactolisib
Restorbio Inc.
Phase 2
60
Connecticut, Massachusetts
2020-10-13
Active, closed
A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)
NCT04529772Diffuse Large B-Cell Lymphoma
DrugsAcalabrutinib·Vincristine·Doxorubicin·Prednisone
Acerta Pharma BV
Phase 3
611
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-10-08
By invitation
Lumbar Interbody Implant Study
NCT04418830Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis
NuVasive
Observational
1,050
California, Connecticut, Florida, Illinois, Michigan, Missouri, North Carolina, Ohio
2020-10-01
Active, closed
Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)
NCT04524611Crohn's Disease (CD)
DrugsSkyrizi·Risankizumab·Ustekinumab
AbbVie
Phase 3
527
Arizona, California, Connecticut, Florida, Georgia, Illinois, Kentucky, Louisiana
2020-09-30
Recruiting
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)
NCT04422912Pemphigus Vulgaris
DrugRese-cel
Cabaletta Bio
Phase 1/2
40
California, Connecticut, Illinois, Iowa, Massachusetts, New York, North Carolina, Pennsylvania
2020-09-29
Active, closed
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
NCT04526665Primary Biliary Cirrhosis
DrugElafibranor
Ipsen
Phase 3
161
Arizona, California, Colorado, Connecticut, Florida, Georgia, Kansas, Massachusetts
2020-09-24
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)
NCT04497844Prostatic Neoplasms
DrugsAbiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 3
696
Alabama, Arizona, California, Colorado, Connecticut, Florida, Indiana, Louisiana
2020-09-23
Active, closed
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
NCT04557449Liposarcoma, Prostate Cancer, Breast Neoplasms, Adenocarcinoma of Lung
DrugsAtirmociclib·Midazolam
Pfizer
Phase 2
362
California, Connecticut, Massachusetts, Michigan, Tennessee, Texas
2020-09-23
Active, closed
Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
NCT04140526Non Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Melanoma, Metastatic Head and Neck Carcinoma
DrugsGotistobart·Taxotere·Docetaxel·Keytruda
OncoC4, Inc.
Phase 1/2
733
Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Kentucky
2020-09-16
Recruiting
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
NCT04462770Dravet Syndrome
DrugClemizole HCl
Epygenix
Phase 3
150
Alabama, Arkansas, California, Connecticut, Delaware, Florida, Georgia, Illinois
2020-09-15
Active, closed
Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
NCT04401748Myelodysplastic Syndrome (MDS)
DrugsVenclexta·Azacitidine·Venetoclax
AbbVie
Phase 3
531
California, Colorado, Connecticut, Delaware, Florida, Idaho, Illinois, Indiana
2020-09-10
Active, closed
Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery
NCT04498117Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma
DrugsOregovomab·Paraplatin·Taxol·Paclitaxel
CanariaBio Inc.
Phase 3
615
Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii, Indiana
2020-08-25
Active, closed
LIFE-BTK Randomized Controlled Trial
NCT04227899Critical Limb Ischemia (CLI)
Abbott Medical Devices
Not applicable
261
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois
2020-08-18
Active, closed
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
NCT04221477Lupus Nephritis
DrugsDiphenhydramine·Acetaminophen·Methylprednisolone·Obinutuzumab
Hoffmann-La Roche
Phase 3
271
Alabama, California, Colorado, Connecticut, Florida, Georgia, New York, Ohio
2020-08-10
Active, closed
Artoss Prospective Spine Registry Outcomes
NCT04439032Spinal Fusion
Artoss Inc.
Observational
330
Arizona, California, Connecticut, Maryland, Mississippi
2020-08-03
Active, closed
Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
NCT04496518Ventricular Tachycardia
Medtronic
Observational
2,200
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-08-01
Active, closed
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
NCT04489225Heart Failure
Medtronic
Observational
2,200
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-08-01
Active, closed
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
NCT04449874Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors
DrugsDivarasib·Erlotinib·Inavolisib·Cetuximab
Genentech, Inc.
Phase 1
498
California, Connecticut, Florida, Massachusetts, New York, Oklahoma, Pennsylvania
2020-07-29
Active, closed
MitraClip REPAIR MR Study
NCT04198870Mitral Valve Regurgitation
Abbott Medical Devices
Not applicable
500
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2020-07-21
Active, closed
AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
NCT04468659Preclinical Alzheimer's Disease, Early Preclinical Alzheimer's Disease
DrugLecanemab
Eisai Inc.
Phase 3
1,400
Alabama, Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Illinois
2020-07-14
Active, closed
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
NCT04245839Lymphoma, Non-Hodgkin
DrugsBreyanzi·Fludarabine·Cyclophosphamide
Celgene
Phase 2
276
California, Colorado, Connecticut, Illinois, Iowa, Kansas, Maryland, Massachusetts
2020-07-14
Active, closed
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
NCT04485013Cancer
DrugsFolfiri·Cetuximab·Pembrolizumab
Tizona Therapeutics, Inc
Phase 1
240
Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Illinois
2020-07-14
Active, closed
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
NCT04493853Hormone-Sensitive Prostate Cancer
DrugsZytiga·Capivasertib·Abiraterone acetate
AstraZeneca
Phase 3
1,012
Arizona, California, Colorado, Connecticut, Florida, Illinois, Maryland, Michigan
2020-07-13
By invitation
Cervical Interbody Implant Study
NCT04689854Degenerative Disc Disease, Cervical Spinal Instability
NuVasive
Observational
150
California, Connecticut, Massachusetts, Missouri, North Carolina, Ohio, Virginia
2020-07-07
Active, closed
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
NCT04232553Crohn's Disease
DrugMirikizumab
Eli Lilly and Company
Phase 3
996
Alabama, Arizona, California, Connecticut, Florida, Georgia, Idaho, Indiana
2020-06-22
Active, closed
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
NCT04437511Alzheimer Disease
DrugDonanemab
Eli Lilly and Company
Phase 3
1,736
Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2020-06-19
Active, closed
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
NCT04181827Multiple Myeloma
DrugsCilta-cel·Pomalidomide·Bortezomib·Daratumumab
Janssen Research & Development, LLC
Phase 3
419
Alabama, Arizona, California, Colorado, Connecticut, Florida, Iowa, Kansas
2020-06-12
Active, closed
A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors
NCT04396821Advanced Cancer, Gastric Cancer, Gastroesophageal-junction Cancer, Pancreatic Cancer
DrugsTST001·MFOLFOX6·Albumin-Bound Paclitaxel·Opdivo
Transcenta Therapeutics (Hangzhou) Co., Ltd.
Phase 1/2
150
Arizona, Connecticut, Florida, Georgia, Kansas, Missouri, New York, North Carolina
2020-05-28
Active, closed
Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma, Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPHA2)
NCT04416984Relapsed or Refractory Large B Cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma
DrugsALLO-647·Fludarabine·Cyclophosphamide
Allogene Therapeutics
Phase 1/2
160
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2020-05-21
Recruiting
A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)
NCT04256317Myelodysplastic Syndromes, Acute Myeloid Leukemia, Myelodysplastic Syndrome/Neoplasm, Chronic Myelomonocytic Leukemia
DrugsVenclexta·Azacitidine·Venetoclax
Taiho Oncology, Inc.
Phase 2/3
316
California, Connecticut, Florida, Georgia, Massachusetts, New Jersey, New York, North Carolina
2020-05-21
Active, closed
Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients
NCT04291105Melanoma, Head and Neck Squamous Cell Carcinoma, Colo-rectal Cancer
DrugsVSV-IFNβ-NIS·Cemiplimab
Vyriad, Inc.
Phase 2
87
California, Connecticut, Florida, Louisiana, Minnesota, Montana, New York, Ohio
2020-04-24
Recruiting
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
NCT04142437Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
DrugLarotrectinib
Bayer
Observational
150
Arizona, California, Colorado, Connecticut, Florida, Indiana, Kansas, Maine
2020-04-03
Active, closed
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer
NCT04223856Urothelial Cancer
DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin
Astellas Pharma Global Development, Inc.
Phase 3
886
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Louisiana
2020-03-30
Active, closed
First-in-Human Study of ICT01 in Patients With Advanced Cancer
NCT04243499Solid Tumor, Adult, Hematopoietic/Lymphoid Cancer
ImCheck Therapeutics, an Ipsen company
Phase 1/2
293
Arizona, California, Connecticut, Florida, New York, Texas, Washington
2020-03-05
Recruiting
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT04221542Prostate Cancer
DrugsXaluritamig·Abiraterone·Enzalutamide
Amgen
Phase 1
479
California, Colorado, Connecticut, Georgia, Indiana, Kansas, Louisiana, Missouri
2020-03-04
Active, closed
DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer
NCT04042701Breast Cancer, Non-small Cell Lung Carcinoma
DrugsTrastuzumab deruxtecan·Keytruda·Pembrolizumab
Daiichi Sankyo
Phase 1
115
California, Connecticut, Florida, Maryland, Massachusetts, Missouri, Pennsylvania, Texas
2020-02-10
Recruiting
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
NCT05986292Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
Eli Lilly and Company
Phase 2
10,000
Alabama, Arizona, California, Connecticut, Florida, Georgia, Idaho, Illinois
2020-01-30
Active, closed
MitraClip EXPAND G4 Study
NCT04177394Mitral Valve Regurgitation, Mitral Regurgitation
Abbott Medical Devices
Observational
1,164
Alabama, Arkansas, California, Connecticut, Florida, Illinois, Kansas, Minnesota
2020-01-17
Active, closed
PROACTIVE-HF IDE Trial Heart Failure NYHA Class III
NCT04089059Heart Failure NYHA Class III
Endotronix, Inc.
Not applicable
738
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2020-01-10
Active, closed
Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET
NCT03972488Gastro-enteropancreatic Neuroendocrine Tumor
DrugsOctreotide LAR·Lutathera
Advanced Accelerator Applications
Phase 3
226
Connecticut, Florida, Iowa, Kentucky, Minnesota, Texas
2020-01-08
Active, closed
Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis
NCT03989206Moderate-to-Severe Atopic Dermatitis
DrugNemolizumab
Galderma R&D
Phase 3
1,700
Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Idaho
2019-12-30
Active, closed
Transforaminal Lumbar Interbody Fusion (TLIF)
NCT04073563Degenerative Disease of the Lumbosacral Spine
Medtronic Spinal and Biologics
Not applicable
600
Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana, Iowa
2019-12-19
Active, closed
Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
NCT04185883Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation
DrugsBI 1701963·TNO155·Sotorasib·Afatinib
Amgen
Phase 1
610
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2019-12-17
Recruiting
Terumo Aortic Global Endovascular Registry
NCT04246463Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
Vascutek Ltd.
Observational
1,000
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Indiana, Michigan
2019-12-17
Recruiting
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
NCT04176198Myelofibrosis
DrugsMomelotinib·Ruxolitinib
Sumitomo Pharma America, Inc.
Phase 1/2
240
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2019-12-16
Active, closed
Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: The STEMI-DTU Trial
NCT03947619ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
Abiomed Inc.
Not applicable
527
Alabama, Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida
2019-12-12
Active, closed
Prophylactic Reinforcement of Ventral Abdominal Incisions Trial
NCT03911700Open Midline Laparotomy
C. R. Bard
Not applicable
477
Arizona, California, Connecticut, Georgia, Illinois, Indiana, Kentucky, Louisiana
2019-12-12
Recruiting
Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)
NCT04202341Generalized Myasthenia Gravis
Alexion Pharmaceuticals, Inc.
Observational
500
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2019-12-02
Active, closed
M6-C Post Approval Study (PAS)
NCT04122248Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Spinal Kinetics
Observational
152
Arizona, California, Colorado, Connecticut, District of Columbia, Illinois, Indiana, Louisiana
2019-11-30
Active, closed
OCS DCD Heart + CAP Continued Follow-Up
NCT05741723Heart Transplant
TransMedics
Observational
276
California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts, Minnesota
2019-11-26
Active, closed
Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance
NCT04150068HIV-1-infection
DrugLenacapavir
Gilead Sciences
Phase 2/3
72
California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Michigan, Missouri
2019-11-21
Active, closed
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma
NCT04133636Multiple Myeloma
DrugsCilta-cel·Bortezomib·Daratumumab·Lenalidomide
Janssen Research & Development, LLC
Phase 2
208
California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas
2019-11-07
Active, closed
The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)
NCT04091984Kidney Transplant Rejection
Natera, Inc.
Observational
5,000
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Illinois
2019-11-06
Active, closed
Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab
NCT04130516Solid Tumor, Adult
DrugsKeytruda·Pembrolizumab
Linnaeus Therapeutics, Inc.
Phase 1/2
200
California, Connecticut, Massachusetts, New Mexico, New York, Pennsylvania, Texas
2019-10-21
Active, closed
Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors
NCT03964727Metastatic Solid Tumor
DrugSacituzumab Govitecan
Gilead Sciences
Phase 2
227
Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Illinois, Indiana
2019-10-15
Active, closed
Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
NCT04136002Colorectal Cancer
Guardant Health, Inc.
Observational
44,467
Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois
2019-10-08
Active, closed
A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DME
NCT04108156Diabetic Macular Edema
DrugsPDS Implant with Ranibizumab·Ranibizumab
Hoffmann-La Roche
Phase 3
672
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2019-09-30
Active, closed
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
NCT04006210Parkinson's Disease
NeuroDerm Ltd.
Phase 3
381
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2019-09-30
Active, closed
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
NCT04083599Malignant Solid Tumor, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Melanoma
DrugsGEN1042·Adrucil·Nab-paclitaxel·Pemetrexed
Genmab
Phase 1/2
350
Alaska, California, Connecticut, Delaware, Florida, Illinois, Kentucky, Maryland
2019-09-17
Active, closed
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
NCT03992404Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
DrugXeomin
Merz Pharmaceuticals GmbH
Phase 3
603
Alabama, Arkansas, California, Connecticut, Florida, Massachusetts, Missouri, New York
2019-09-16
Active, closed
TRILUMINATE Pivotal Trial
NCT03904147Tricuspid Regurgitation
Abbott Medical Devices
Not applicable
572
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2019-08-21
Recruiting
A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors
NCT03972657Metastatic Castration-Resistant Prostate Cancer (mCRPC), Clear Cell Renal Cell Carcinoma (ccRCC)
DrugsNezastomig·Cemiplimab
Regeneron Pharmaceuticals
Phase 1/2
345
Arizona, California, Colorado, Connecticut, Florida, Massachusetts, Michigan, Minnesota
2019-08-12
Recruiting
Pan Tumor Rollover Study
NCT03899155Cancer
DrugsRucaparib·Sunitinib·Trametinib·Relatlimab
Bristol-Myers Squibb
Phase 2
1,500
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Illinois
2019-08-09
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NCT03821129Stroke, PFO - Patent Foramen Ovale
W.L.Gore & Associates
Not applicable
636
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2019-07-25
Active, closed
Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
NCT03836040Migraine
Amgen
Phase 3
457
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana
2019-07-19
Active, closed
An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)
NCT03897881Melanoma
DrugsIntismeran autogene·Pembrolizumab
ModernaTX, Inc.
Phase 2
267
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2019-07-18
Active, closed
IBP-9414 for the Prevention of Necrotizing Enterocolitis - The Connection Study
NCT03978000Necrotizing Enterocolitis
Infant Bacterial Therapeutics
Phase 3
2,158
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois
2019-07-04
Active, closed
Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)
NCT03944772Non-Small Cell Lung Cancer
DrugsNecitumumab·Gefitinib·Savolitinib·Selpercatinib
AstraZeneca
Phase 2
247
California, Connecticut, Illinois, Maryland, Massachusetts, Michigan, New York, Oregon
2019-06-25
Active, closed
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
NCT03767244Prostatic Neoplasms
DrugApalutamide
Janssen Research & Development, LLC
Phase 3
2,517
California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana, Massachusetts
2019-06-11
Active, closed
An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia
NCT04053803Sickle Cell Disease
Imara, Inc.
Phase 2
30
Connecticut, Florida, Texas
2019-05-22
Active, closed
A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
NCT03893955Cancer, Advanced Solid Tumors, Triple-Negative Breast Cancer (TNBC), Non-small-cell-lung-cancer (NSCLC)
DrugsABBV-927·Budigalimab·Nab-paclitaxel·Carboplatin
AbbVie
Phase 1
150
Arkansas, California, Connecticut, Florida, Indiana, Missouri, North Carolina, Pennsylvania
2019-05-21
Active, closed
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561Diabetes Mellitus, Type 2
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,500
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2019-05-08
Active, closed
Extension Study to Evaluate Safety and Efficacy of CTP-543 in Adults With Alopecia Areata
NCT03898479Alopecia Areata
Sun Pharmaceutical Industries, Inc.
Phase 2/3
1,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Idaho
2019-04-04
Active, closed
A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease
NCT03887455Early Alzheimer's Disease
DrugLecanemab
Eisai Inc.
Phase 3
1,906
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Hawaii
2019-03-27
Active, closed
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy
NCT03675308Psoriatic Arthritis
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
964
Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois
2019-03-25
Active, closed
Avelumab Program Rollover Study
NCT03815643Solid Tumors
DrugAvelumab
EMD Serono Research & Development Institute, Inc.
Phase 3
205
Arizona, Arkansas, California, Connecticut, Florida, Georgia, Maryland, Michigan
2019-03-22
Active, closed
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
NCT03860272Advanced Cancer, Angiosarcoma, Colorectal Cancer Without Liver Metastases, Endometrial Cancer
DrugsBalstilimab·Botensilimab
Agenus Inc.
Phase 1
499
Arizona, California, Colorado, Connecticut, Florida, Massachusetts, New York, Oregon
2019-03-20
Active, closed
Real-World Data Study of Troriluzole-Treated Patients With Spinocerebellar Ataxia (SCA) Compared to a Matched Natural History Control
NCT06529146Spinocerebellar Ataxias
DrugTroriluzole
Biohaven Therapeutics Ltd.
Observational
909
Connecticut
2019-03-18
Active, closed
A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer
NCT03816163Pancreatic Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma
DrugsZolbetuximab·Nab-paclitaxel·Gemcitabine
Astellas Pharma Global Development, Inc.
Phase 2
393
California, Connecticut, Florida, Georgia, Illinois, Kentucky, Louisiana, Missouri
2019-03-15
Recruiting
Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT03850574Leukemia, Myeloid, Acute, Refractory AML, Relapsed Adult AML, Myelodysplastic Syndrome With Excess Blasts-2
DrugsAzacitidine·Venetoclax
Aptose Biosciences Inc.
Phase 1/2
240
Alabama, California, Connecticut, Florida, Georgia, Massachusetts, North Carolina, Ohio
2019-03-11
Active, closed
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
NCT03768063Cancer
DrugsEmactuzumab·Rucaparib·Cobimetinib·Vemurafenib
Hoffmann-La Roche
Phase 3
1,000
Colorado, Connecticut, Massachusetts, North Carolina, Pennsylvania, Texas
2019-02-28
Active, closed
Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors
NCT03821935Advanced Solid Tumors Cancer
DrugsLivmoniplimab·Budigalimab
AbbVie
Phase 1
364
Arkansas, California, Connecticut, Florida, Indiana, Michigan, Missouri, Montana
2019-02-21
Active, closed
A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib
NCT03673501Gastrointestinal Stromal Tumors
DrugsRipretinib·Sunitinib
Deciphera Pharmaceuticals, LLC
Phase 3
453
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2019-02-08
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
NCT03748641Castration-Resistant Prostatic Cancer
DrugsAbiraterone acetate·Niraparib·Prednisone
Janssen Research & Development, LLC
Phase 3
765
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Illinois
2019-01-25
Active, closed
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
NCT03785249Advanced Cancer, Metastatic Cancer, Malignant Neoplastic Disease
DrugsAdagrasib·Afatinib·Cetuximab·Pembrolizumab
Mirati Therapeutics Inc.
Phase 1/2
731
Alabama, Alaska, Arizona, California, Colorado, Connecticut, Delaware, Florida
2019-01-15
Active, closed
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
NCT03682536Myelodysplastic Syndromes
DrugsEpoetin Alfa·Luspatercept
Celgene
Phase 3
363
California, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Missouri, New Jersey
2019-01-02
Active, closed
Surveillance HeartCare® Outcomes Registry
NCT03695601Heart Transplant Rejection
CareDx
Observational
2,743
Arizona, Arkansas, California, Connecticut, District of Columbia, Florida, Georgia, Illinois
2018-12-28
Active, closed
The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension
NCT03614260Hypertension, Vascular Diseases, Cardiovascular Diseases
ReCor Medical, Inc.
Not applicable
224
Alabama, California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Louisiana
2018-12-14
Active, closed
A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer
NCT03701334Early Breast Cancer
DrugRibociclib
Novartis Pharmaceuticals
Phase 3
5,101
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2018-12-07
Active, closed
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
NCT03732677Muscle Invasive Bladder Cancer
DrugsDurvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,063
Alabama, California, Connecticut, Illinois, Iowa, Kansas, Kentucky, Louisiana
2018-11-16
Recruiting
Medtronic Terminate AF Study
NCT03546374Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Medtronic Cardiac Surgery
Not applicable
160
California, Connecticut, Indiana, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania
2018-11-15
Active, closed
Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study
NCT03635424Bicuspid Aortic Valve
Medtronic Cardiovascular
Not applicable
150
Arizona, California, Connecticut, Florida, Georgia, Iowa, Massachusetts, Michigan
2018-10-30
Active, closed
A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
NCT03596645Colitis, Ulcerative
DrugsGolimumab·Infliximab
Janssen Research & Development, LLC
Phase 3
84
California, Colorado, Connecticut, Delaware, Georgia, Minnesota, New York, Tennessee
2018-10-29
Active, closed
A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
NCT03602859Ovarian Neoplasms, Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
DrugsNiraparib·Dostarlimab
Tesaro, Inc.
Phase 3
1,400
Alaska, Arizona, California, Connecticut, Florida, Illinois, Louisiana, Maine
2018-10-11
Active, closed
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
NCT03690388Differentiated Thyroid Cancer
DrugCabozantinib
Exelixis
Phase 3
187
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Kentucky, Massachusetts
2018-10-05
Active, closed
Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy
NCT03703297Small Cell Lung Cancer
DrugsTremelimumab·Durvalumab
AstraZeneca
Phase 3
730
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky
2018-09-27
Active, closed
Study of Durvalumab Given With Chemotherapy, Durvalumab in Combination With Tremelimumab Given With Chemotherapy, or Chemotherapy in Patients With Unresectable Urothelial Cancer
NCT03682068Unresectable Locally Advanced Urothelial Cancer, Metastatic Urothelial Cancer
DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,246
Alabama, California, Connecticut, District of Columbia, Florida, Illinois, Indiana, Kansas
2018-09-27
Recruiting
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157Spinal Muscular Atrophy (SMA)
DrugZolgensma
Novartis Pharmaceuticals
Observational
700
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2018-09-25
Recruiting
Extension Study for the Port Delivery System With Ranibizumab (Portal)
NCT03683251Neovascular Age-Related Macular Degeneration
DrugPDS Implant with Ranibizumab
Hoffmann-La Roche
Phase 3
1,000
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2018-09-20
Active, closed
Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)
NCT03553836Melanoma
DrugsKeytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
976
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2018-09-12
Active, closed
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis
NCT03398135Ulcerative Colitis (UC)
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
1,242
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Kansas
2018-08-28
Recruiting
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
NCT03486873Solid Tumors, Hematologic Malignancies
DrugsPembrolizumab/Favezelimab·) Berahyaluronidase alfa·Olaparib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
3,500
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Hawaii
2018-08-21
By invitation
Advanced Materials Science in XLIF Study
NCT03649490Degenerative Disc Disease, Spondylolisthesis
NuVasive
Observational
300
Connecticut, Florida, Illinois, Kentucky, Maryland, Minnesota, Missouri, North Carolina
2018-08-19
Active, closed
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
NCT03547973Metastatic Urothelial Cancer
DrugsDomvanalimab·Zimberelimab·Avelumab·Enfortumab Vedotin
Gilead Sciences
Phase 2
502
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2018-08-13
Active, closed
A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
NCT03568318Atopic Dermatitis
DrugUpadacitinib
AbbVie
Phase 3
1,533
Alabama, Arizona, California, Colorado, Connecticut, Florida, Idaho, Illinois
2018-08-09
Active, closed
Open-Label Study of AG10 in Patients with Cardiomyopathy
NCT03536767Amyloid Cardiomyopathy
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 2
55
California, Connecticut, Illinois, Massachusetts, Minnesota, New York, Oregon, South Carolina
2018-08-08
Active, closed
Post Approval Study Investigating Lutonix Drug Coated Balloon for Treatment of Dysfunctional Arteriovenous Fistulae
NCT03506308Arteriovenous Fistula
C. R. Bard
Not applicable
213
Alabama, California, Connecticut, Iowa, Kentucky, Louisiana, Maryland, Massachusetts
2018-08-07
Recruiting
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
NCT03435796Neoplasms
Celgene
Phase 2/3
1,541
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2018-07-19
Active, closed
X-linked Hypophosphatemia Disease Monitoring Program
NCT03651505X-linked Hypophosphatemia, Hypophosphatemic Rickets
Ultragenyx Pharmaceutical Inc
Observational
782
Alabama, California, Colorado, Connecticut, Illinois, Indiana, Maryland, Massachusetts
2018-07-16
Active, closed
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors
NCT03485209Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Exocrine Pancreatic Cancer, Carcinoma, Squamous Cell of Head and Neck
DrugsTisotumab Vedotin·Tivdak·Keytruda·Cisplatin
Seagen, a wholly owned subsidiary of Pfizer
Phase 2
350
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Kansas
2018-06-25
Active, closed
A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy in Adults With Gastric Cancer.
NCT03504397Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
DrugsZolbetuximab·Folinic acid·Fluorouracil·Oxaliplatin
Astellas Pharma Global Development, Inc.
Phase 3
565
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2018-06-21
Recruiting
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
NCT03556228Head and Neck Carcinoma, Adenoid Cystic Carcinoma, Lung Cancer, Non-Small Cell Lung Cancer
VM Oncology, LLC
Phase 1/2
242
California, Connecticut, District of Columbia, Florida, New Jersey, New Mexico, New York, Ohio
2018-06-08
Active, closed
A Study of Runimotamab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers
NCT03448042Solid Tumors
DrugsTocilizumab·Trastuzumab
Genentech, Inc.
Phase 1
123
Connecticut, Michigan, New York, Tennessee, Texas
2018-06-06
Active, closed
A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy
NCT03522246Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Newly Diagnosed
DrugsRucaparib·Opdivo·Nivolumab
pharmaand GmbH
Phase 3
1,097
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2018-05-14
Active, closed
Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study
NCT03381274Carcinoma, Non-Small-Cell Lung
DrugsOleclumab·Tagrisso·Osimertinib
MedImmune LLC
Phase 1/2
43
California, Colorado, Connecticut, Georgia, Illinois, Maryland, New York, Texas
2018-05-08
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
NCT03425643Non-small Cell Lung Cancer
DrugsPemetrexed·Keytruda·Gemcitabine·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
797
Arizona, California, Connecticut, Delaware, Florida, Georgia, Illinois, Indiana
2018-04-24
Active, closed
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
NCT03438747Degenerative Disc Disease
CeraPedics, Inc
Not applicable
290
Alabama, California, Colorado, Connecticut, Florida, Illinois, Indiana, Kentucky
2018-04-24
Recruiting
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977Metastatic Castration Resistant Prostate Cancer (mCRPC), Small Cell Lung Cancer (SCLC), Follicular Lymphoma (FL)
DrugsMevrometostat·Xtandi·Itraconazole·Enzalutamide
Pfizer
Phase 1
453
Arizona, California, Connecticut, Kansas, Kentucky, Maryland, Massachusetts, Nebraska
2018-04-17
Active, closed
Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)
NCT03407144Hodgkin Lymphoma
DrugsPrednisone/Prednisolone·Vinblastine·Bleomycin·Dacarbazine
Merck Sharp & Dohme LLC
Phase 2
340
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2018-04-09
Active, closed
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
NCT03105102Crohn's Disease
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
1,336
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois
2018-04-09
Active, closed
Study of Patients Receiving DUPIXENT® for Atopic Dermatitis (AD)
NCT03428646Dermatitis, Atopic
DrugDupilumab
Regeneron Pharmaceuticals
Observational
858
Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana
2018-04-06
Active, closed
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
NCT03345823Crohn's Disease
DrugUpadacitinib
AbbVie
Phase 3
747
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Idaho
2018-03-21
Active, closed
To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.
NCT03330847Metastatic Triple Negative Breast Cancer
DrugCeralasertib
AstraZeneca
Phase 2
273
Alabama, Alaska, Arizona, Colorado, Connecticut, Illinois, Indiana, Kentucky
2018-03-07
Recruiting
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver
Massive Bio, Inc.
Observational
50,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida
2018-01-01
Recruiting
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
NCT03394365Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant
DrugTabelecleucel
Pierre Fabre Medicament
Phase 3
115
California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Maryland, Massachusetts
2017-12-29
Recruiting
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
NCT03328078Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy, Relapsed Primary Central Nervous System Lymphoma, Refractory Primary Central Nervous System Lymphoma
DrugsEmavusertib·Ibrutinib
Curis, Inc.
Phase 1/2
152
Arizona, California, Connecticut, Florida, Illinois, Massachusetts, Minnesota, Nebraska
2017-12-28
Active, closed
Study Evaluating Safety, Tolerability and Pharmacokinetics (PK) of Tarlatamab in Adults With Small Cell Lung Cancer (SCLC)
NCT03319940Small Cell Lung Carcinoma
DrugsTarlatamab·Pembrolizumab
Amgen
Phase 1
269
California, Connecticut, Florida, Georgia, Illinois, Louisiana, Maryland, Michigan
2017-12-26
Active, closed
Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection
NCT03033043Aortic Dissection Type B
Bolton Medical
Not applicable
56
California, Colorado, Connecticut, District of Columbia, Georgia, Illinois, Indiana, Iowa
2017-12-14
Active, closed
Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)
NCT03301506Primary Biliary Cirrhosis
DrugSeladelpar
Gilead Sciences
Phase 3
340
Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana
2017-12-12
By invitation
Patient Outcomes With Robotic-Assisted Total Knee Arthroplasty
NCT06203756Arthroplasties, Knee Replacement, Revision Arthroplasty
Corin
Not applicable
713
Arizona, Connecticut, Michigan, New York, Oklahoma, Wisconsin
2017-11-09
Recruiting
Givinostat in Duchenne's Muscular Dystrophy Long-term Safety and Tolerability Study
NCT03373968Duchenne Muscular Dystrophy
DrugHydroxyurea
Italfarmaco
Phase 2/3
206
California, Connecticut, Florida, Georgia, Iowa, Missouri, Oregon, Pennsylvania
2017-10-24
Recruiting
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.
NCT03242642Mitral Valve Regurgitation
Medtronic Cardiovascular
Not applicable
1,056
Alabama, Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Illinois
2017-10-23
Active, closed
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
NCT03148418Cancer
DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab
Hoffmann-La Roche
Phase 3
382
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2017-09-20
Active, closed
ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population
NCT03153449Primary Knee Arthroplasty
DePuy Orthopaedics
Not applicable
400
California, Colorado, Connecticut, Florida, Kentucky, Mississippi, New Hampshire, New Jersey
2017-09-19
Active, closed
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
NCT03170960Urothelial Carcinoma, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Castration-resistant Prostate Cancer
DrugsCabozantinib·Tecentriq·Atezolizumab
Exelixis
Phase 1
914
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2017-09-05
Active, closed
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
NCT02962414Tuberous Sclerosis Complex
DrugEverolimus
Novartis Pharmaceuticals
Phase 3
206
Arizona, California, Colorado, Connecticut, Illinois, Minnesota, New Jersey, Ohio
2017-08-23
Active, closed
Personalized Therapy Study - Attain Stability Quad Post-Approval Study
NCT04024943Heart Failure
Medtronic
Observational
1,092
Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2017-08-21
Active, closed
EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis
NCT03042104Heart Diseases, Aortic Stenosis, Severe
Edwards Lifesciences
Not applicable
901
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2017-07-12
Active, closed
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
NCT03155997Breast Cancer
DrugAbemaciclib
Eli Lilly and Company
Phase 3
5,637
Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Florida
2017-07-12
Active, closed
A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease
NCT03100149Parkinson's Disease
DrugPrasinezumab
Hoffmann-La Roche
Phase 2
316
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Kansas
2017-06-27
Active, closed
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
NCT03165734Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
DrugPacritinib
Swedish Orphan Biovitrum
Phase 3
407
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Illinois
2017-06-26
Active, closed
ATTUNE Revision System in the Revision Total Knee Arthroplasty Population
NCT03153475Revision Total Knee Arthroplasty
DePuy Orthopaedics
Not applicable
400
California, Colorado, Connecticut, Florida, Kentucky, Mississippi, Missouri, New Hampshire
2017-05-30
Recruiting
Safety Study of MELK Inhibitor to Treat Patients With Advanced Breast Cancer and Triple Negative Breast Cancer
NCT02926690Relapsed/Refractory Locally Advanced or Metastatic Breast Cancer and Triple Negative Breast Cancer
OncoTherapy Science, Inc.
Phase 1
70
Connecticut, Georgia, Hawaii, New Hampshire, New York, Texas, Wisconsin
2017-05-29
Active, closed
INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections
NCT03037164Anemia
Cerus Corporation
Phase 3
692
Arizona, Connecticut, Florida, Georgia, Maryland, Nevada, Tennessee, Texas
2017-05-11
Active, closed
RelayPro Thoracic Stent-Graft in Subjects With Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers
NCT02818972Aortic Aneurysm, Thoracic, Penetrating Ulcer
Bolton Medical
Not applicable
110
Alabama, Arizona, California, Connecticut, Florida, Georgia, Indiana, Iowa
2017-05-10
Active, closed
A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
NCT03157128Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, Colon Cancer, Any Solid Tumor
DrugSelpercatinib
Eli Lilly and Company
Phase 1/2
857
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana
2017-05-02
Recruiting
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
NCT03053193Breast Cancer
Agendia
Observational
30,000
Alabama, Alaska, Arizona, California, Colorado, Connecticut, Delaware, Florida
2017-04-28
Active, closed
Study of the Relay Pro® Thoracic Stent-Graft in Subjects With Traumatic Injury of the Descending Thoracic Aorta
NCT03090230Other Specified Injury of Thoracic Aorta
Bolton Medical
Not applicable
50
California, Connecticut, Georgia, Indiana, Iowa, Maryland, Massachusetts, Missouri
2017-04-17
Active, closed
A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL
NCT02972840Lymphoma, Mantle Cell
DrugsAcalabrutinib·Bendamustine·Rituximab
Acerta Pharma BV
Phase 3
635
Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Kansas, Kentucky
2017-04-05
Active, closed
Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)
NCT03043872Small Cell Lung Carcinoma Extensive Disease
DrugsTremelimumab·Etoposide·Durvalumab·Cisplatin
AstraZeneca
Phase 3
987
Alabama, Arizona, Arkansas, California, Connecticut, Georgia, Indiana, Kansas
2017-03-27
Active, closed
Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial
NCT03108456Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
Abbott Medical Devices
Not applicable
2,005
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2017-03-27
Recruiting
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
NCT03072927Lumbar Spinal Stenosis
Stryker Instruments
Observational
8,000
Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware
2017-03-10
Active, closed
A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)
NCT03006068Ulcerative Colitis (UC)
DrugUpadacitinib
AbbVie
Phase 3
950
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2017-01-31
Recruiting
PARTNER 3 Trial - Aortic Valve-in-Valve
NCT03003299Aortic Stenosis, Aortic Stenosis, Severe
Edwards Lifesciences
Not applicable
125
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana
2017-01-05
Active, closed
Venglustat in Combination With Cerezyme in Adult Patients With Gaucher Disease Type 3 With Venglustat Monotherapy Extension
NCT02843035Gaucher Disease Type 1, Gaucher Disease Type 3
DrugsImiglucerase·Venglustat
Genzyme, a Sanofi Company
Phase 2
12
Connecticut, Texas, Virginia
2017-01-04
Active, closed
The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
NCT02979587Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
Medtronic Heart Valves
Not applicable
86
California, Connecticut, Minnesota, Ohio, Pennsylvania, Texas, Utah, Washington
2017-01
Active, closed
Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer
NCT02546661Muscle Invasive Bladder Cancer
DrugsDanvatirsen·Fexagratinib·Vistusertib·Adavosertib
AstraZeneca
Phase 1
117
California, Connecticut, Florida, New York, Ohio, Tennessee
2016-12-28
Active, closed
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
NCT02951598Alzheimer Disease, Mild Cognitive Impairment
Eli Lilly and Company
Observational
1,400
California, Colorado, Connecticut, Florida, Georgia, Indiana, Kansas, Kentucky
2016-10-29
Active, closed
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 2
NCT02777593Aortic Aneurysm, Thoracic, Aorta; Lesion
W.L.Gore & Associates
Not applicable
250
California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana, Kentucky
2016-09-06
Active, closed
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 0/1
NCT02777528Aortic Aneurysm, Thoracic, Aorta, Lesion
W.L.Gore & Associates
Not applicable
79
California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana, Maryland
2016-08
Active, closed
A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
NCT02655016Ovarian Neoplasms
DrugNiraparib
Tesaro, Inc.
Phase 3
733
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa
2016-07-11
Active, closed
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT02817633Neoplasms
DrugsCobolimab·Dostarlimab·Pemetrexed·Docetaxel
Tesaro, Inc.
Phase 1
463
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2016-07-08
Active, closed
A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy
NCT02677922Leukemia, Myeloid, Acute
DrugsEnasidenib·Ivosidenib·Azacitidine
Celgene
Phase 1/2
130
California, Connecticut, Illinois, Massachusetts, New York, Texas
2016-06-03
Active, closed
Study of Iomab-B vs. Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia
NCT02665065Acute Myeloid Leukemia, Leukemia, Acute Myeloid, Myeloid Leukemia, Acute, Leukemia, Myeloid, Acute
Actinium Pharmaceuticals
Phase 3
153
Arizona, Connecticut, District of Columbia, Florida, Illinois, Iowa, Kansas, Minnesota
2016-06
Recruiting
Neurologic Stem Cell Treatment Study
NCT02795052Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
MD Stem Cells
Not applicable
500
Connecticut, Florida
2016-06
Active, closed
BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI)
NCT02805023Chronic Limb-Threatening Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
BioGenCell Ltd.
Phase 1/2
40
California, Connecticut, Maryland
2016-06
Active, closed
Clinical Effectiveness Assessment of VeriStrat® Testing and Validation of Immunotherapy Tests in NSCLC Subjects
NCT03289780Non-Small Cell Lung Cancer
Biodesix, Inc.
Observational
5,006
Alabama, Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana
2016-04-04
Active, closed
DS-3201b in Participants With Lymphomas
NCT02732275Lymphoma, Malignant, Non-hodgkin Lymphoma
DrugValemetostat Tosylate
Daiichi Sankyo Co., Ltd.
Phase 1
100
California, Connecticut, Georgia, Massachusetts, New Jersey, New York, North Carolina, Ohio
2016-03-31
Active, closed
A Study of the ReCor Medical Paradise System in Clinical Hypertension
NCT02649426Hypertension, Vascular Diseases
ReCor Medical, Inc.
Not applicable
282
Alabama, California, Connecticut, Florida, Georgia, Illinois, Indiana, Louisiana
2016-03
Active, closed
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
NCT02675114Aortic Stenosis
Edwards Lifesciences
Not applicable
1,000
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2016-03
Active, closed
Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients
NCT02701283Aortic Valve Stenosis
Medtronic Cardiovascular
Not applicable
2,223
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2016-03
Active, closed
Study to Evaluate Imetelstat (GRN163L) in Participants With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
NCT02598661Myelodysplastic Syndromes
DrugImetelstat Sodium
Geron Corporation
Phase 2/3
289
Alabama, Arizona, California, Connecticut, Florida, Indiana, Maryland, Missouri
2016-01-12
Recruiting
Stem Cell Ophthalmology Treatment Study II
NCT03011541Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
MD Stem Cells
Not applicable
500
Connecticut, Florida
2016-01
Active, closed
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
NCT02659215Defect of Articular Cartilage
Anika Therapeutics, Inc.
Not applicable
200
Arizona, California, Connecticut, Florida, Illinois, Louisiana, Nevada, New York
2015-12
Active, closed
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
NCT02489318Prostate Cancer
DrugApalutamide
Aragon Pharmaceuticals, Inc.
Phase 3
1,052
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana
2015-11-27
Active, closed
An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS
NCT02531516Prostatic Neoplasms
DrugsGnRH·Bicalutamide·Apalutamide
Aragon Pharmaceuticals, Inc.
Phase 3
1,503
Alabama, Arizona, California, Colorado, Connecticut, Florida, Idaho, Illinois
2015-11-19
Active, closed
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
NCT02568267Breast Cancer, Cholangiocarcinoma, Colorectal Cancer, Head and Neck Neoplasms
DrugEntrectinib
Hoffmann-La Roche
Phase 2
534
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2015-11-19
Active, closed
On-X Aortic Prosthetic Heart Valve Low Dose Warfarin Post Approval Clinical Registry Study
NCT02677974Thrombotic and Bleeding Events
On-X Life Technologies, Inc.
Observational
510
Arizona, Connecticut, Indiana, Maine, North Dakota, Ohio, Oregon, Texas
2015-11-10
Active, closed
Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer
NCT02516241Urothelial Cancer
DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,126
California, Colorado, Connecticut, Florida, Georgia, Kentucky, Massachusetts, Michigan
2015-11-02
Active, closed
AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.
NCT02511106Stage IB-IIIA Non-small Cell Lung Carcinoma
DrugOsimertinib
AstraZeneca
Phase 3
682
California, Colorado, Connecticut, Florida, Georgia, Hawaii, Illinois, Maryland
2015-10-21
Active, closed
A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma
NCT02519348Hepatocellular Carcinoma
DrugsTremelimumab·Durvalumab·Bevacizumab
MedImmune LLC
Phase 2
433
Arizona, California, Connecticut, Florida, Indiana, Massachusetts, New York, North Carolina
2015-10-19
Active, closed
An Open Label Study of CM-AT for the Treatment of Children With Autism
NCT02649959Autism
Curemark
Phase 3
405
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Louisiana
2015-10
Recruiting
Total Shoulder Arthroplasty Multi-Center Registry
NCT03511586Shoulder Arthroplasty
Arthrex, Inc.
Observational
2,500
Arizona, Colorado, Connecticut, Florida, Illinois, Indiana, Michigan, Missouri
2015-07-28
Active, closed
Phase III Open Label First Line Therapy Study of MEDI 4736 (Durvalumab) With or Without Tremelimumab Versus SOC in Non Small-Cell Lung Cancer (NSCLC)
NCT02453282Non-Small-Cell Lung Carcinoma NSCLC
DrugsTremelimumab·Durvalumab·Pemetrexed·Gemcitabine
AstraZeneca
Phase 3
1,118
Arizona, California, Connecticut, Florida, Georgia, Hawaii, Maryland, Minnesota
2015-07-21
Active, closed
Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
NCT02503423Solid Tumors, Lymphoma
DrugTolinapant
Taiho Oncology, Inc.
Phase 1/2
253
Alabama, Arizona, California, Connecticut, Georgia, Illinois, Maryland, Massachusetts
2015-07-14
Active, closed
Micra Transcatheter Pacing System Post-Approval Registry
NCT02536118Bradycardia
Medtronic
Observational
3,100
Alabama, California, Connecticut, District of Columbia, Florida, Georgia, Indiana, Iowa
2015-07
Active, closed
Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients
NCT02362503HIV Infections
ViiV Healthcare
Phase 3
371
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana
2015-02-23
By invitation
RegisterNET - A Registry for Neuroendocrine Tumors in the USA and Worldwide
NCT02270567Neuroendocrine Tumor, Carcinoid, Neuroendocrine Carcinoma
Wren Laboratories LLC
Observational
400
Connecticut
2015-02
By invitation
Registry of Patients With Hypophosphatasia
NCT02306720Hypophosphatasia (HPP)
Alexion Pharmaceuticals, Inc.
Observational
1,571
Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Minnesota, Missouri
2015-01-20
Active, closed
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
NCT02319837Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate
DrugsLupron·Eligard·Leuprorelin·Xtandi
Pfizer
Phase 3
1,068
Alabama, Alaska, Arizona, California, Colorado, Connecticut, Florida, Georgia
2014-12-17
Active, closed
A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)
NCT02293980ccRCC, RCC, Kidney Cancer, Clear Cell Renal Cell Carcinoma
DrugsBelzutifan·Cabozantinib·Opdivo·Nivolumab
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 1
110
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Maryland
2014-11-25
Active, closed
A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)
NCT02130362Crohn's Disease
AbbVie
Observational
1,446
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Louisiana
2014-08-28
Active, closed
A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer
NCT02138734Non-muscle Invasive Bladder Cancer
ImmunityBio, Inc.
Phase 1/2
369
Alabama, Alaska, Arizona, Arkansas, California, Connecticut, Florida, Georgia
2014-07-21
Active, closed
PERIGON Pivotal Trial
NCT02088554Aortic Stenosis
Medtronic Cardiac Surgery
Not applicable
1,312
California, Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Michigan
2014-05-12
Active, closed
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
NCT02032823Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
1,837
Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware
2014-04-22
Active, closed
Clinical Study of the Treovance Stent-Graft for Patients With Abdominal Aortic Aneurysms
NCT02009644Abdominal Aortic Aneurysm (AAA)
Bolton Medical
Not applicable
158
Alabama, Arizona, Connecticut, Florida, Georgia, Illinois, Iowa, Massachusetts
2013-11-23
Active, closed
A Long-term Extension Study of PCI-32765 (Ibrutinib)
NCT01804686Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma
DrugIbrutinib
Janssen Research & Development, LLC
Phase 3
539
California, Connecticut, Georgia, Illinois, Indiana, Kansas, Kentucky, Massachusetts
2013-09-09
Active, closed
Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy
NCT01874353Platinum Sensitive, BRCA Mutated, Relapsed Ovarian Cancer, Following Complete or Partial Response to Platinum Based Chemotherapy
DrugOlaparib
AstraZeneca
Phase 3
327
Alabama, California, Colorado, Connecticut, Florida, Illinois, Maryland, Massachusetts
2013-09-03
Active, closed
Olaparib Maintenance Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy.
NCT01844986Newly Diagnosed, Advanced Ovarian Cancer, FIGO Stage III-IV, BRCA Mutation
DrugOlaparib
AstraZeneca
Phase 3
450
Alabama, Alaska, Arizona, California, Colorado, Connecticut, Florida, Georgia
2013-08-26
Active, closed
Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma
NCT01843374Unresectable Pleural or Peritoneal Malignant Mesothelioma
DrugTremelimumab
MedImmune LLC
Phase 2
571
Arizona, California, Connecticut, Delaware, Florida, Georgia, Illinois, Maryland
2013-05-17
Active, closed
A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC)
NCT01848561Ulcerative Colitis (UC)
AbbVie
Observational
8,250
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2013-04-29
Active, closed
A Study of LY2784544 in Participants With Myeloproliferative Neoplasms
NCT01594723Neoplasms, Hematologic
Eli Lilly and Company
Phase 2
110
Arkansas, California, Connecticut, Florida, Illinois, Indiana, Kansas, Maryland
2012-05-22
Recruiting
Patient Retrospective Outcomes (PRO)
NCT01550575Chronic Pain
Boston Scientific Corporation
Observational
15,000
Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii, Idaho
2012-04-03
Active, closed
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).
NCT01586910Severe Aortic Stenosis
Medtronic Cardiovascular
Not applicable
1,746
Arizona, California, Connecticut, District of Columbia, Florida, Georgia, Hawaii, Illinois
2012-04
Recruiting
Product Surveillance Registry
NCT01524276Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
Medtronic
Observational
100,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2012-01
Active, closed
Psoriasis Longitudinal Assessment and Registry
NCT00508547Psoriasis
Janssen Scientific Affairs, LLC
Observational
20,167
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia
2007-06-21
Active, closed
A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease
NCT00606346Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis, Inflammatory Bowel Diseases
Janssen Biotech, Inc.
Observational
4,970
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Idaho
2007-05-31
Active, closed
PhII ICb With/Without Erbitux in MBC Pts
NCT00248287Metastatic Breast Cancer
DrugsErbitux·Irinotecan·Carboplatin
US Oncology Research
Phase 2
154
Alabama, Arizona, Colorado, Connecticut, Florida, Illinois, Indiana, Kansas
2005-07-28
Active, closed
Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.
NCT00099437Breast Cancer
DrugFulvestrant
AstraZeneca
Phase 3
736
Arizona, California, Connecticut, Florida, Illinois, Maryland, Michigan, Missouri
2005-02-13
Recruiting
Pompe Disease Registry Protocol
NCT00231400Glycogen Storage Disease Type II, Pompe Disease
Genzyme, a Sanofi Company
Observational
2,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2004-09-15
Recruiting
Fabry Disease Registry & Pregnancy Sub-registry
NCT00196742Fabry Disease
Genzyme, a Sanofi Company
Observational
9,000
Alabama, Arizona, Arkansas, California, Connecticut, District of Columbia, Florida, Georgia
2001-07-31
Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
NCT00358943Gaucher Disease, Cerebroside Lipidosis Syndrome, Glucocerebrosidase Deficiency Disease, Glucosylceramide Beta-Glucosidase Deficiency Disease
Genzyme, a Sanofi Company
Observational
12,000
Arizona, Arkansas, California, Connecticut, District of Columbia, Florida, Georgia, Illinois
1991-04-01
Recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180Arrhythmia, Bradycardia, Heart Failure, Sinus Tachycardia
Medtronic
Observational
20,000
Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia
1983-01
Rows per page Showing 1001–1273 of 1273
Previous 1 2 3
Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 7 October 2026. https://priyalifescience.com/clinical-trials-usa/state/connecticut?page=3

Query this register directly
GET /api/trials?country=usa&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,273 of those studies with a site in Connecticut.

How many clinical trials are recruiting in Connecticut?

643 of the 1,273 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 20 have not yet opened recruitment, 577 are active but closed to new participants, and 33 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.