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Trackers› Clinical trials› Bonn
Clinical trial register · Germany

Clinical Trials in Bonn, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Germany and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 5051 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:51 UTC
5051
Studies in scope
all four open statuses
2882
Recruiting now
open to new participants
988
Lead sponsors
across recruiting studies
Top sites
Berlin 1584 Hamburg 889 Essen 760 Dresden 707 Heidelberg 627
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca34 University Hospital, Bonn24 University of Bonn12 Hoffmann-La Roche11 Boehringer Ingelheim9
Site location
Berlin1584 Hamburg889 Essen760 Dresden707 Heidelberg627
All 635 locations
Target enrolment
to

Trials with a site in Bonn

413 of 5051 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Germany
Start
Not yet open
A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease
NCT07431294Stable Coronary Artery Disease
DrugNitroglycerin
Bayer
Phase 1
36
Heidelberg, Bonn, Erfurt, Berlin
2027-01-01
Not yet open
A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma
NCT07728188Relapsed or Refractory Multiple Myeloma
DrugsEtentamig·Teclistamab·Carfilzomib·Pomalidomide
AbbVie
Phase 3
520
Freiburg im Breisgau, Karlsruhe, Tübingen, Ulm, Würzburg, Hanover, Bonn, Cologne
2026-11-30
Not yet open
A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A
NCT07830732Haemophilia A
Novo Nordisk A/S
Phase 3
84
Berlin, Bonn, Hanover, Leipzig, Regensburg
2026-10-09
Not yet open
Torvutatug Samrotecan With or Without Bevacizumab as Maintenance Treatment of Platinum-sensitive Relapsed Epithelial Ovarian Cancer
NCT07816666Platinum-sensitive Relapsed Epithelial Ovarian Cancer, Platinum-sensitive Relapsed Fallopian Tube Cancer, Platinum-sensitive Relapsed Primary Peritoneal Cancer
DrugsTorvutatug samrotecan·Bevacizumab
AstraZeneca
Phase 3
600
Bad Homburg, Bonn, Brandenburg, Gütersloh, Homburg, Kassel, Mainz, Mannheim
2026-09-29
Recruiting
FIBRONEER-ACT: A Study to Test Whether Nerandomilast Helps People With Fibrosing Interstitial Lung Disease at Risk for Disease Progression
NCT07540988Interstitial Lung Diseases
DrugNerandomilast
Boehringer Ingelheim
Phase 3
466
Berlin, Bonn, Essen, Hanover, Heidelberg, Immenhausen, München, Stuttgart
2026-09-14
Recruiting
A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)
NCT07624305Renal Insufficiency, Chronic
DrugsBalcinrenone/dapagliflozin·Dapagliflozin
AstraZeneca
Phase 3
2,800
Aachen, Bad Nenndorf, Berlin, Bonn, Brandenburg an der Havel, Braunschweig, Cloppenburg, Essen
2026-09-01
Not yet open
Study of Serine Supplementation to Protect Vision in MacTel
NCT07342439Macular Telangiectasia Type 2 (MacTel)
The Lowy Medical Research Institute Limited
Phase 3
120
Bonn, Freiburg im Breisgau, Münster
2026-09
Not yet open
Longitudinal Effects of Brain Stimulation on Decision-Making and Reward Learning
NCT07823218Depression / Major Depressive Disorder
Dr. Nils B. Kroemer
Observational
100
Bonn
2026-09
Recruiting
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
NCT07753993Chronic Kidney Disease
DrugElecoglipron
AstraZeneca
Phase 3
7,000
Ahrensburg, Bad Mergentheim, Bad Nenndorf, Berlin, Bonn, Brandenburg an der Havel, Braunschweig, Chemnitz
2026-08-21
Recruiting
Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature
NCT05314998Pancreatic Ductal Adenocarcinoma
DrugsFolinic acid·Irinotecan·Adrucil·Capecitabine
John Neoptolemos
Phase 3
394
Aachen, Augsburg, Bochum, Bonn, Deggendorf, Dresden, Erlangen, Frankfurt
2026-08-17
Recruiting
A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)
NCT07742735Short Bowel Syndrome (SBS), SBS Associated With Intestinal Failure (SBS-IF)
DrugApraglutide
VectivBio AG
Phase 3
124
Heidelberg, Erlangen, Hamburg, Bonn, Essen, Münster, Aachen, Berlin
2026-08
Recruiting
Evaluation of the Efficacy and Safety of Magnetic Resonance Angiography (MRA) Using Gadopiclenol Compared to Gadoterate Meglumine in the Assessment of Steno-occlusive Disease in Adult Patients With Suspected Vascular Disease
NCT07348640Steno-occlusive Disease
DrugsGadopiclenol·Gadoterate meglumine
Guerbet
Phase 3
315
Berlin, Bonn, Essen, Homburg, Kiel, Lübeck, München
2026-07-28
Recruiting
An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC
NCT07720284High-risk Muscle Invasive Urothelial Carcinoma
DrugsRilvegostomig·Enfortumab Vedotin·Datopotamab deruxtecan·Opdivo
AstraZeneca
Phase 3
915
Bochum, Bonn, Dresden, Duisburg, Frankfurt am Main, Hamburg, Hanover, Herne
2026-07-16
Recruiting
DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy
NCT07544654Extrapulmonary Neuroendocrine Cancer (epNEC)
DrugsObrixtamig·Etoposide·Carboplatin
Boehringer Ingelheim
Phase 3
390
Berlin, Bonn, Cologne, Dresden, Düsseldorf, Erlangen, Freiburg im Breisgau, Hamburg
2026-07-10
Recruiting
Evaluation of an Exercise Intervention During Intensive Medical Treatment in Pediatric Oncology.
NCT07647471Pediatric Cancer Patients
Universität Duisburg-Essen
Not applicable
346
Berlin, Bonn, Cologne, Essen, Frankfurt, Hamburg, Jena, Mainz
2026-07-01
Recruiting
Investigation of the Individual Fatigue Response During Blood Flow Restriction Training
NCT07611526Total Knee Anthroplasty
University Hospital, Bonn
Not applicable
20
Bonn
2026-06-26
Recruiting
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
NCT07652658Idiopathic Pulmonary Fibrosis (IPF)
AstraZeneca
Phase 2
359
Bonn, Essen, Freiburg im Breisgau, Fulda, Giessen, Hamburg, Hanover, Heidelberg
2026-06-11
Recruiting
Phase III Randomized International Open Label Clinical Trial of Treatment Intensification With Docetaxel Plus Apalutamide in Patients With Metastatic Hormone-sensitive Prostate Cancer Who Did Not Achieve a Deep PSA Response After Initial Treatment With Apalutamide: REINFORCE Trial.
NCT07333066Metastatic Hormone-sensitive Prostate Cancer
DrugsApalutamide (Erleada)·Docetaxel
Alianza multidisciplinar para la investigación de los tumores genitourinarios -GUARD
Phase 3
320
Berlin, Bonn, Gera, Göttingen, Halle, Karlsruhe, Recklinghausen, Rostock
2026-06-05
Recruiting
A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy
NCT07498426Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)
Novartis Pharmaceuticals
Phase 3
300
Munich, Würzburg, Bonn, Düsseldorf, Dresden, Leipzig, Beelitz, Berlin
2026-06-03
Recruiting
Measuring Corneal Parameters
NCT07629232Corneal Parameters
Icare Finland Oy
Not applicable
50
Bonn
2026-06-01
Not yet open
An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function
NCT07613398Congenital Heart Diseases, Cardiac Diseases
Matthias Stuber
Observational
300
Bonn, Cologne, Berlin
2026-06
Recruiting
A Study in Children and, Adults With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Treated With Adzynma
NCT07353099Thrombotic Thrombocytopenic Purpura (TTP)
Takeda
Observational
50
Bonn, Cologne, Jena, Leipzig, München
2026-05-26
Recruiting
A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A
NCT07416526Hemophilia A
Hoffmann-La Roche
Phase 3
138
Bonn
2026-05-15
Recruiting
Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1
NCT07486934Myotonic Dystrophy Type 1 (DM1), DM1, Myotonic Dystrophy, Steinert Disease
DrugZeleciment basivarsen
Dyne Therapeutics
Phase 3
150
Munich, Göttingen, Bonn, Berlin
2026-05-14
Recruiting
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
NCT07287098Breast Neoplasms
DrugsImlunestrant·Goserelin·Tamoxifen
Eli Lilly and Company
Phase 2
600
Bergisch Gladbach, Berlin, Bielefeld, Bochum, Bonn, Bottrop, Braunschweig, Bremen
2026-05-13
Recruiting
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
NCT07611110Metastatic Castration-resistant Prostate Cancer
DrugsFPI-2265·Xofigo·Cabazitaxel·Zytiga
AstraZeneca
Phase 3
670
Augsburg, Berlin, Bonn, Cologne, Dresden, Essen, Jena, Karlsruhe
2026-05-04
Not yet open
Retinal Ganglion Cell Neuroprotection Under Prostaglandin Analogues
NCT07074782Glaucoma
Association for Innovation and Biomedical Research on Light and Image
Observational
1,500
Bonn, Leipzig
2026-05
Recruiting
Multicenter Study for the Validation of Willem AI: Aortic StenoSis Early Diagnosis With AI-electrocardiogram Study
NCT07479992Aortic Stenosis
Idoven 1903 S.L.
Observational
5,000
Bonn, Munich
2026-04-28
Recruiting
A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A
NCT07416604Hemophilia A
DrugEmicizumab
Hoffmann-La Roche
Phase 3
360
Bonn
2026-04-27
Recruiting
Visugromab in Cachexia International Trial
NCT07112196Cancer-associated Cachexia
DrugVisugromab
CatalYm GmbH
Phase 2/3
518
Bonn, Dresden, Großhansdorf, München
2026-04-16
Recruiting
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
NCT07522073Solid Tumors
DrugINCB161734
Incyte Corporation
Phase 3
588
Berlin, Bochum, Bonn, Cologne, Dresden, Düsseldorf, Essen, Frankfurt
2026-04-09
Recruiting
Nuwiq Dosing and Outcomes In the ManagEment of Women/Girls With Haemophilia A Needing FVIII Treatment for Surgery
NCT05936580Hemophilia A
DrugNuwiq
Octapharma
Phase 4
28
Bonn, Duisburg, Hamburg
2026-04
Recruiting
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
NCT07476469Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
Dr. Nils B. Kroemer
Not applicable
104
Bonn
2026-03-23
Recruiting
A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
NCT07441642Geographic Atrophy Secondary to Age-related Macular Degeneration
Novartis Pharmaceuticals
Phase 2
272
Ludwigshafen, Bonn, Münster, Tübingen
2026-03-09
Recruiting
Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)
NCT07223814Acute Myeloid Leukemia
DrugsBleximenib·Idarubicin·Daunorubicin·Cytarabine
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
875
Aachen, Bochum, Bonn, Greifswald, Halle, Hanover, Heilbronn, Karlsruhe
2026-03-01
Recruiting
Enhanced Vision and Imaging Tests for Enabling Treatment Trials in Early and Intermediate AMD
NCT07515521Age - Related Macular Degeneration (AMD)
Maximilian Pfau
Observational
150
Bonn
2026-02-15
Recruiting
A Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to Acoramidis
NCT07298044Transthyretin Amyloid Cardiomyopathy
DrugAcoramidis
Bayer
Phase 4
50
Ulm, Darmstadt, Greifswald, Bonn, Berlin, Hamburg
2026-02-13
Recruiting
Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS
NCT07197944Short Bowel Syndrome
DrugGlepaglutide
Zealand Pharma
Phase 3
90
Rostock, Leipzig, Aachen, Berlin, Bonn, Hamburg
2026-02-11
Recruiting
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
NCT07431281Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Esophageal Cancer
DrugsSonesitatug Vedotin·Zolbetuximab·Rilvegostomig·Leucovorin
AstraZeneca
Phase 3
2,130
Augsburg, Bad Saarow, Berlin, Bonn, Dresden, Essen, Frankfurt, Freiburg im Breisgau
2026-02-03
Recruiting
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
NCT07322003Amyotrophic Lateral Sclerosis
DrugPridopidine
Prilenia
Phase 3
500
Berlin, Bonn, Jena, München, Ulm
2026-02-01
Recruiting
Effect of Virtual Reality Use on Preoperative Anxiety
NCT07270445Anxiety
Vera Guttenthaler
Not applicable
172
Bonn
2026-01-28
Recruiting
Neoadjuvant Darovasertib in Primary Uveal Melanoma
NCT07015190Uveal Melanoma
DrugDarovasertib
IDEAYA Biosciences
Phase 3
520
Tübingen, Ulm, Erlangen, Essen, Dessau, Berlin, Bonn, Lübeck
2026-01-25
Recruiting
TARGET 2.0 Study: Safety and Performance of the Cardiovalve TR Replacement System
NCT07334691Tricuspid Regurgitation
Cardiovalve Ltd.
Not applicable
150
Bonn
2026-01-20
Recruiting
Vorasidenib Maintenance for IDH Mutant Astrocytoma
NCT06809322IDH-mutant Grade 2 or 3 Astrocytoma
DrugVorasidenib
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
468
Bonn, Frankfurt, Heidelberg, Mannheim, Regensburg
2026-01-16
Recruiting
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
NCT07179380Pulmonary Hypertension, Interstitial Lung Disease
DrugTreprostinil Palmitil
Insmed Incorporated
Phase 3
344
Heidelberg, Immenhausen, Stuttgart, München, Bonn, Essen, Homburg, Dresden
2026-01-07
Recruiting
Comparing XEN®-63 Gel Stent and PRESERFLO® MicroShunt
NCT07359547GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Universitaire Ziekenhuizen KU Leuven
Not applicable
166
Bonn
2026-01-01
Recruiting
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
NCT07218809Epithelial Ovarian Cancer
DrugsTorvutatug samrotecan·MIRV·Mirvetuximab Soravtansine·Pegylated liposomal doxorubicin
AstraZeneca
Phase 3
1,100
Berlin, Bonn, Detmold, Dresden, Düsseldorf, Essen, Frankfurt am Main, Hamburg
2025-12-29
Recruiting
Study of Cabozantinib in Participants With Neuroendocrine Tumors Who Have Already Received Prior Treatment
NCT07314164Neuroendocrine Tumors
Ipsen
Observational
150
Aschaffenburg, Berlin, Bonn, Bremen, Chemnitz, Cologne, Dresden, Erlangen
2025-12-17
Recruiting
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
NCT07218380Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis
DrugsVepugratinib·Pembrolizumab
Eli Lilly and Company
Phase 3
450
Bad Saarow, Bielefeld, Bonn, Cologne, Dresden, Duisburg, Düsseldorf, Erlangen
2025-12-12
Active, closed
Efficacy and Safety Evaluation of Glepaglutide in Treatment of Short Bowel Syndrome
NCT07228403Short Bowel Syndrome (SBS)
DrugGlepaglutide
Zealand Pharma
Phase 3
28
Frankfurt am Main, Rostock, Bonn, Berlin, Hamburg
2025-12-11
Recruiting
A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese
NCT07326111Polycystic Ovary Syndrome (PCOS), Obesity & Overweight
University of Bonn
Phase 4
198
Bochum, Bonn
2025-12-09
Recruiting
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
NCT07214779Ovarian Cancer
DrugINCB123667
Incyte Corporation
Phase 3
466
Berlin, Bonn, Dresden, Essen, Kassel, Kiel, Mannheim, Minden
2025-12-09
Recruiting
Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on Active SGLT2 Inhibitor Treatment Admitted for Acute Decompensated Heart Failure
NCT07038356Acute Decompensated Heart Failure (ADHF)
DrugDapagliflozin
Christian Schulze
Phase 3
536
Jena, Bad Nauheim, Berlin, Bonn, Dresden, Göttingen, Halle, Leipzig
2025-12-08
Recruiting
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
NCT07324330Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
University Hospital, Bonn
Not applicable
130
Bonn
2025-12-04
Recruiting
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
NCT07221253Biliary Tract Cancer
DrugsGemcitabine/Cisplatin·Rilvegostomig·Durvalumab
AstraZeneca
Phase 3
1,100
Aachen, Berlin, Bonn, Düsseldorf, Essen, Frankfurt, Freiburg im Breisgau, Hamburg
2025-12-04
Recruiting
A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasis
NCT07250802Plaque Psoriasis
DrugZasocitinib
Takeda
Phase 3
110
Bad Bentheim, Cologne, Münster, Bonn, Mainz
2025-12-04
Recruiting
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
NCT07276399Squamous Cell Carcinoma of Head and Neck
DrugsAmivantamab·Cisplatin·Carboplatin·Pembrolizumab
Janssen Research & Development, LLC
Phase 3
500
Bonn, Essen, Frankfurt, Giessen, Hanover, Leipzig, Regensburg, Rostock
2025-12-03
Recruiting
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
NCT07201558Rheumatoid Arthritis, Systemic Lupus Erythematosus
DrugSurovatamig
AstraZeneca
Phase 1
48
Bonn, Jena, Mainz, München, Münster
2025-12-02
Recruiting
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
NCT07213674Metastatic Castration-resistant Prostate Cancer
DrugsXaluritamig·Cabazitaxel·Abiraterone acetate·Docetaxel
Amgen
Phase 3
750
Berlin, Bonn, Dresden, Erlangen, Essen, Hamburg, Heidelberg, Jena
2025-11-28
Recruiting
Safety and Efficacy Evaluation of the iNstroke 4F Thromboaspiration Catheter in Patients With Acute Ischaemic Stroke Due to Primary Distal Medium Vessel Occlusions (DMVO)
NCT07357285Acute Ischemic Stroke
iVascular S.L.U.
Not applicable
57
Bonn, Kiel, Marburg, Nuremberg, Recklinghausen
2025-11-27
Recruiting
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
NCT07228832Metastatic Colorectal Cancer (CRC)
DrugsIvonescimab·Leucovorin·Adrucil·Oxaliplatin
Summit Therapeutics
Phase 3
600
Berlin, Bonn, Hamburg
2025-11-18
Recruiting
Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma
NCT07260175Cholangiocarcinoma, IDH Mutation
DrugIvosidenib
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 2
40
Aachen, Bonn, Essen, Frankfurt, Giessen, Göttingen, Hamburg, Jena
2025-11-18
Recruiting
Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Hip Infection: a Microdialysis Study
NCT07299591Periprosthetic Hip Infection
University Hospital, Bonn
Observational
30
Bonn
2025-11-15
Recruiting
Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee Infection: a Microdialysis Study
NCT07299565Periprosthetic Knee Infection
University Hospital, Bonn
Observational
30
Bonn
2025-11-15
Active, closed
A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07170150Alzheimers Disease
DrugTrontinemab
Hoffmann-La Roche
Phase 3
1,060
Erlangen, Berlin, Bonn, Cologne, Dresden, Homburg/Saar, Jena, Leipzig
2025-11-12
Recruiting
Phase 2 Study of ADX-038 in Participants With Geographic Atrophy
NCT06990269Geographic Atrophy Secondary to Age-related Macular Degeneration
ADARx Pharmaceuticals, Inc.
Phase 2
240
Bonn, Sulzbach, Cologne, Giessen, Mainz, München, Münster, Tübingen
2025-11-10
Recruiting
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
NCT07007065Neovascular Age-related Macular Degeneration
DrugSurabgene Lomparvovec
AbbVie
Phase 3
561
Freiburg im Breisgau, Tübingen, Ulm, Munich, Göttingen, Hanover, Bonn, Ludwigshafen am Rhein
2025-11-05
Recruiting
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
NCT07291037Non-small Cell Lung Cancer (NSCLC)
DrugsDatopotamab deruxtecan·Docetaxel
AstraZeneca
Phase 3
400
Bad Saarow, Bielefeld, Bonn, Cologne, Essen, Frankfurt, Freiburg im Breisgau, Gauting
2025-10-31
Recruiting
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
NCT06659445Geographic Atrophy (GA), Age - Related Macular Degeneration (AMD)
DrugAvacincaptad Pegol
ONL Therapeutics
Phase 2
324
Ahaus, Bonn, Düsseldorf, Frankfurt am Main, Marburg, Würzburg
2025-10-28
Recruiting
A Research Study Looking at How Different Doses of Study Medicine (Inno8) Work in the Body of People With Haemophilia A
NCT07220564Haemophilia A
Novo Nordisk A/S
Phase 1
30
Berlin, Bonn, Hanover
2025-10-23
Recruiting
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
NCT07213804Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
DrugsSofe-M·MIRV·Pegylated liposomal doxorubicin·Topotecan
Eli Lilly and Company
Phase 3
1,630
Aachen, Berlin, Bonn, Cologne, Dresden, Düsseldorf, Erlangen, Essen
2025-10-22
Recruiting
Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure
NCT06750536Extracorporeal Membrane Oxygenation Complication, Neonatal Aspiration Pneumonia, Acute Respiratory Failure, Acute Lung Injury
Xenios AG
Observational
20
Bonn, Mannheim
2025-10-12
Recruiting
tVNS, Motivation, and Insulin Sensitivity
NCT07198100Major Depressive Disorder (MDD)
University of Bonn
Not applicable
120
Bonn
2025-10-10
Recruiting
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
NCT07144280Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Carcinoma
DrugsPF-08046054·Docetaxel
Pfizer
Phase 3
680
Heidelberg, Stuttgart, Hösbach, Frankfurt am Main, Giessen, Immenhausen, Kassel, Bonn
2025-09-29
Recruiting
A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases
NCT06806592Interstitial Lung Diseases, Systemic Autoimmune Rheumatic Diseases Associated Interstitial Lung Diseases
DrugNerandomilast
Boehringer Ingelheim
Phase 3
400
Berlin, Bonn, Braunschweig, Bremen, Cologne, Düsseldorf, Essen, Freiburg im Breisgau
2025-09-13
Recruiting
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT06973187Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsTacabrutideg·Pirtobrutinib
BeOne Medicines
Phase 3
500
Bochum, Bonn, Cologne, Dortmund, Karlsruhe, Lübeck, Stuttgart, Ulm
2025-09-04
Recruiting
A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety
NCT07019922Epileptic Encephalopathy, SCN2A Encephalopathy
Praxis Precision Medicines
Phase 3
40
Bonn
2025-08-13
Recruiting
German Registry of Alzheimer's Disease Treated With Transcranial Pulse Stimulation
NCT06313944Alzheimer Disease
Heinrich-Heine University, Duesseldorf
Observational
100
Potsdam, Oldenburg, Bonn, Neuss, Kempen, Ulm
2025-08-06
Recruiting
Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy
NCT07075016Acute Myeloid Leukemia
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
227
Berlin, Bochum, Bonn, Braunschweig, Bremen, Darmstadt, Flensburg, Freiburg im Breisgau
2025-08-05
Recruiting
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433Atherosclerotic Cardiovascular Disease, Overweight, Obesity
DrugMaridebart cafraglutide
Amgen
Phase 3
12,800
Bad Homburg, Bad Krozingen, Bad Oeynhausen, Berlin, Bochum, Bonn, Detmold, Dortmund
2025-07-25
Recruiting
Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
NCT06950385Familial Adenomatous Polyposis (FAP)
DrugERapa
Rapamycin Holdings Inc.
Phase 3
168
Bonn
2025-07-18
Recruiting
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
NCT06991114Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs), Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA
Artiva Biotherapeutics, Inc.
Phase 2
90
Bonn, München
2025-07-09
Not yet open
Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating CfDNA/NETs in Subjects with Sepsis
NCT05647096Sepsis, Respiratory Failure
Santersus AG
Not applicable
73
Bonn, Dresden, Hannover
2025-07-01
Recruiting
A Study to Assess the Efficacy and Safety of Emicizumab in Participants With Type 3 Von Willebrand Disease
NCT06998524Von Willebrand Disease, Type 3
DrugEmicizumab
Hoffmann-La Roche
Phase 3
75
Bonn, Duisburg, Frankfurt/M.
2025-06-27
Recruiting
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction, Obesity
DrugMaridebart cafraglutide
Amgen
Phase 3
5,056
Bad Berka, Bad Neustadt an der Saale, Bad Segeberg, Berlin, Bonn, Detmold, Dresden, Düsseldorf
2025-06-25
Recruiting
Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Anterior Cruciate Ligament Reconstruction
NCT07043569ACL - Anterior Cruciate Ligament Rupture
University Hospital, Bonn
Not applicable
30
Bonn
2025-06-20
Recruiting
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
NCT06972446Rheumatoid Arthritis
DrugsABBV-8736·ABBV-701·Lutikizumab·Adalimumab
AbbVie
Phase 2
180
Wetzlar, Bonn, Cologne, Hamburg
2025-06-20
Recruiting
Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance
NCT06658730Vascular Disease, Dissection, Dissection Aortic Aneurysm, Dissection of Aorta
W.L.Gore & Associates
Observational
1,500
Bonn, Frankfurt, Regensburg, Ulm
2025-06-19
Active, closed
A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis
NCT06832618Atopic Dermatitis
DrugRuxolitinib
Incyte Corporation
Phase 3
159
Bad Bentheim, Bonn, Chemnitz, Dresden, Frankfurt, Göttingen, Kiel, Mainz
2025-06-17
Recruiting
Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 (redePHine)
NCT06839235Primary Hyperoxaluria Type 1 (PH1)
Arbor Biotechnologies
Phase 1/2
23
Bonn
2025-06-16
Recruiting
A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD
NCT07038200Facioscapulohumeral Muscular Dystrophy, FSHD, FSHD - Facioscapulohumeral Muscular Dystrophy, FSHD1
DrugDel-brax
Avidity Biosciences, Inc.
Phase 3
200
Bonn, Göttingen, München, Ulm
2025-06-10
Recruiting
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
NCT06872892Bronchiectasis
DrugVerducatib
Boehringer Ingelheim
Phase 3
1,755
Aachen, Ahrensburg, Bamberg, Berlin, Bochum, Bonn, Cologne, Donaustauf
2025-06-09
Recruiting
A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome
NCT06872125Dravet Syndrome
DrugZorevunersen
Stoke Therapeutics, Inc
Phase 3
170
Berlin, Bonn, Frankfurt, Friedberg, Heidelberg, München
2025-06-04
Recruiting
Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time
NCT06874296Liver Transplantation, Liver Diseases, Surgery
Charite University, Berlin, Germany
Not applicable
186
Hamburg, Aachen, Bonn, Münster, Berlin, Hanover, München, Regensburg
2025-06-02
Recruiting
Multicenter Study for the Validation of an AI-based ECG Platform for Early Cardiac Amyloidosis Diagnosis
NCT06978660Transthyretin Cardiac Amyloidosis
Idoven 1903 S.L.
Observational
2,200
Bonn, München
2025-05-27
Recruiting
Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa
NCT06940830Hemophilia A
DrugEfanesoctocog alfa
Swedish Orphan Biovitrum
Phase 4
250
Berlin, Bonn, Frankfurt am Main, Hamburg, Munich
2025-05-21
Recruiting
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
NCT06935370Heart Failure
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
4,200
Bad Friedrichshall, Bamberg, Berlin, Bonn, Bünde, Coburg, Dresden, Erfurt
2025-05-20
Recruiting
NIS to Examine the Effectiveness and Safety of Durvalumab and Olaparib in Patients With Endometrial Cancer (DUOLife)
NCT06890273Endometrial Cancer
AstraZeneca
Observational
150
Amberg, Bad Nauheim, Bautzen, Berlin, Bielefeld, Bonn, Borna, Bottrop
2025-05-20
Recruiting
Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression
NCT06967857Attention-Deficit/Hyperactivity Disorder (ADHD), Depression - Major Depressive Disorder
Prof. Dr. Frank Behrens
Phase 2
105
Berlin, Bonn, Frankfurt, Leipzig, München
2025-05-15
Recruiting
Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)
NCT06924021Age-Related Macular Degeneration
University of Wisconsin, Madison
Observational
1,000
Bonn
2025-05-12
Recruiting
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
NCT06499285Myelodysplastic Syndromes
DrugElritercept
Takeda
Phase 3
225
Bonn, Düsseldorf, Leipzig, Halle, Magdeburg, Berlin
2025-05-06
Recruiting
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
NCT06921785Hepatocellular Carcinoma
DrugsRilvegostomig·Tremelimumab·Atezolizumab·Bevacizumab
AstraZeneca
Phase 3
1,220
Aachen, Berlin, Bonn, Dortmund, Dresden, Essen, Frankfurt, Göttingen
2025-05-06
Recruiting
Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML
NCT06652438Acute Myeloid Leukemia, Adult
DrugRevumenib
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
448
Berlin, Bochum, Bonn, Braunschweig, Bremen, Darmstadt, Essen, Flensburg
2025-05-05
Recruiting
Video-Tumorboard PLUS
NCT06980740Malignant Melanoma, Telemedicine
University Hospital Muenster
Observational
300
Bonn, Dresden, Münster
2025-05-01
Active, closed
An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment
NCT06883240Von Willebrand Disease, Type 3
DrugsActivated Prothrombin Complex·Recombinant Factor VIIa
Hoffmann-La Roche
Observational
44
Bonn, Duisburg, Frankfurt/M.
2025-04-29
Recruiting
Immunochemotherapy, Surgery or Chemoradiation, and Durvalumab for Stage IIIA/B NSCLC
NCT06810609Lung Cancer Non-Small Cell Cancer (NSCLC)
University Hospital, Bonn
Phase 2
176
Freiburg im Breisgau, Stuttgart, Giessen, Minden, Bonn
2025-04-20
Active, closed
A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis
NCT06934226Plaque Psoriasis
DrugsIcotrokinra·Ustekinumab
Janssen Research & Development, LLC
Phase 3
752
Augsburg, Bad Bentheim, Berlin, Bonn, Bramsche, Darmstadt, Dresden, Friedrichshafen
2025-04-15
Recruiting
A Contrast Medium Sparing Strategy Using Automated CO2 Injection During PVI for Prevention of Major Adverse Kidney Events (MAKE)
NCT06656988Peripheral Vascular Diseases, Kidney Diseases
University of Leipzig
Phase 3
1,960
Alsfeld, Bad Krozingen, Bonn, Chemnitz, Flensburg, Frankfurt a.M., Leipzig, München
2025-04-14
Recruiting
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
NCT06868277Carcinoma, Non-Small Cell Lung
DrugsRilvegostomig·Keytruda·Pembrolizumab
AstraZeneca
Phase 3
830
Amberg, Augsburg, by, Bad Saarow, Berlin, Bonn, Braunschweig, Essen, Flensburg
2025-04-10
By invitation
tVNS and Obesity-related Mechanisms
NCT06954844Overweight/Obesity (BMI: 27 and 35 kg/m2)
University of Bonn
Not applicable
60
Bonn
2025-04-08
Recruiting
Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
NCT07150000Rheumatic Diseases, Rheumatoid Arthritis (RA), Giant Cell Arteritis (GCA), Psoriatic Arthritis (PsA)
University of Bonn
Observational
120
Bonn
2025-04-01
Active, closed
European Multicenter Validation of PCaVision: A Head-to-Head Diagnostic Accuracy Study Comparing Multiparametric Transrectal Ultrasound to MRI for Clinically Significant Prostate Cancer Detection
NCT06935487Prostate Cancer
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Not applicable
806
Bonn, Hamburg, Planegg
2025-04-01
Recruiting
Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II
NCT06615102Cardiac Surgery, Vasoplegia
DrugsAngiotensin II·Noradrenalin
Universität Münster
Phase 3
1,022
Berlin, Bonn, Mainz, Münster
2025-03-31
Recruiting
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
NCT06750289Eosinophilic Asthma
AstraZeneca
Phase 3
400
Berlin, Bonn, Cottbus, Delitzsch, Frankfurt am Main, Geesthacht, Hemer, Landsberg
2025-03-28
Recruiting
A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
NCT06644781Esophageal Squamous Cell Carcinoma
DrugsIfinatamab Deruxtecan·Irinotecan·Docetaxel·Paclitaxel
Daiichi Sankyo
Phase 3
510
Berlin, Bonn, Dresden, Frankfurt am Main, Hamburg, Jena, Leipzig, Nuremberg
2025-03-27
Active, closed
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
NCT06764485Metastatic Castration-resistant Prostate Cancer
DrugsAbiraterone·Enzalutamide·Docetaxel
Celgene
Phase 3
960
Nürtingen, München, Lübeck, Jena, Bonn, Essen, Hamburg, Heidelberg
2025-03-13
Recruiting
Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib
NCT06855498Hidradenitis Suppurativa (HS)
DrugPovorcitinib
Incyte Corporation
Phase 3
600
Aachen, Bad Bentheim, Berlin, Bochum, Bonn, Buxtehude, Darmstadt, Dortmund
2025-02-28
Recruiting
Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock
NCT05726825Septic Shock
Hannover Medical School
Not applicable
274
Berlin, Bonn, Braunschweig, Bremerhaven, Cologne, Erlangen, Essen, Halle
2025-02-19
Recruiting
Low-Intensity Oscillatory Magnetic Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) - An Exposure-time Escalation Pilot Trial
NCT06533163Glioblastoma Multiforme
BioTex, Inc.
Not applicable
30
Stuttgart, München, Bonn, Lünen, Leipzig, Mannheim
2025-02-17
By invitation
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
NCT06908226Developmental and Epileptic Encephalopathy
DrugBexicaserin
Longboard Pharmaceuticals
Phase 3
324
Bielefeld, Bonn, Kiel, Frankfurt am Main
2025-02-12
Active, closed
Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer
NCT06619236Platinum-resistant Ovarian Cancer
DrugsRina-S·Pegylated liposomal doxorubicin·Topotecan·Gemcitabine
Genmab
Phase 3
530
Berlin, Bonn, Dresden, Düsseldorf, Essen, Frankfurt, Giessen, Hamburg
2025-02-07
Recruiting
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
NCT06712355Extensive-stage Small-cell Lung Cancer
DrugsPumitamig·Etoposide·Atezolizumab·Carboplatin
BioNTech SE
Phase 3
621
Berlin, Bonn, Chemnitz, Esslingen am Neckar, Gauting, Gera, Großhansdorf, Halle
2025-02-03
Recruiting
Cyclosporine In Takotsubo Syndrome
NCT05946772Takotsubo Cardiomyopathy
DrugCyclosporine A
University Hospital Heidelberg
Phase 2
204
Bad Nauheim, Berlin, Bonn, Cologne, Dresden, Düsseldorf, Essen, Frankfurt
2025-02-01
Active, closed
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)
NCT06799000Hidradenitis Suppurativa
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
588
Langenau, Darmstadt, Dresden, Halle, Berlin, Bochum, Bonn, Erlangen
2025-01-31
Recruiting
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
NCT06585774Chronic Graft-versus-host-disease
DrugsAxatilimab·Prednisolone·Methylprednisolone·Prednisone
Incyte Corporation
Phase 3
240
Aachen, Berlin, Bonn, Dresden, Düsseldorf, Erlangen, Essen, Halle
2025-01-21
Recruiting
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
NCT06743126Melanoma, Cutaneous Malignant
DrugsAnzu-cel·Lifileucel·Temodar·Dacarbazine
Immatics US, Inc.
Phase 3
360
Cologne, Berlin, Bonn, Dresden, Erlangen, Essen, Frankfurt am Main, Hamburg
2025-01-14
Recruiting
A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD
NCT06659549Geographic Atrophy of the Macula
Galimedix Therapeutics Inc
Phase 2
110
Bonn, Freiburg im Breisgau, Hanover, Neubrandenburg, Tübingen, Ulm
2025-01-10
Not yet open
Effects of a Legume-rich Diet in the Context of the Planetary Health Diet Compared to a Western-oriented Dietary Pattern in Participants with Increased Cardiometabolic Risk
NCT06700954Cardiovascular Diseases
University of Bonn
Not applicable
100
Bonn
2025-01-06
Recruiting
Impact of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Elective Hip Replacement
NCT07043127Total Hip Arthroplasty (THA)
University Hospital, Bonn
Not applicable
30
Bonn
2025-01-01
Recruiting
Early Catheter-directed Treatment of High Risk Pulmonary Embolism
NCT06672081Pulmonary Embolism Acute Massive
Leipzig Heart Science gGmbH
Not applicable
210
Bad Krozingen, Bautzen, Bonn, Düsseldorf, Erfurt, Frankfurt am Main, Halle, Hamburg
2024-12-27
Recruiting
Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
NCT06472245Patients With Non-Small Cell Lung Cancer
DrugsTedopi·Docetaxel
OSE Immunotherapeutics
Phase 3
363
Heidelberg, Stuttgart, Gauting, München, Kassel, Aachen, Bonn, Essen
2024-12-03
Recruiting
Anterior Temporal Lobectomy in Temporal Glioblastoma
NCT07021339Newly-diagnosed Glioblastoma, Temporal Lobe
University Hospital, Bonn
Phase 3
178
Bonn
2024-11-28
Recruiting
AYLo - AutoimmunitY and Loss of y
NCT06696027Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
University of Bonn
Observational
500
Bonn
2024-11-15
Active, closed
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)
NCT06719141Developmental and Epileptic Encephalopathy
DrugBexicaserin
Longboard Pharmaceuticals
Phase 3
367
Frankfurt am Main, Bielefeld, Bonn, Radeberg, Kiel, Ravensburg
2024-11-11
Recruiting
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
NCT06541704Age-related Macular Degeneration (AMD), Geographic Atrophy (GA)
DrugsCemdisiran·Pozelimab
Regeneron Pharmaceuticals
Phase 3
975
Ulm, Berlin, Frankfurt am Main, Marburg, Neubrandenburg, Bonn, Düsseldorf, Münster
2024-10-30
Recruiting
A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease
NCT06585449Huntington's Disease
Alnylam Pharmaceuticals
Phase 1
66
Berlin, Bochum, Bonn, Dresden, Münster, Taufkirchen, Ulm
2024-10-14
Recruiting
A Phase II Randomized, Open Label Non-inferiority Study of NiraParib Maintenance After 3 vs. 6 Cycles of Platinum-based Chemotherapy in completeLy debUlked Advanced HRDpositive High-grade Ovarian Cancer patientS in First Line Therapy
NCT05460000Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Clear Cell Carcinoma
North Eastern German Society of Gynaecological Oncology
Phase 2
640
Aachen, Baden-Baden, Berlin, Bonn, Cologne, Detmold, Dortmund, Dresden
2024-10-11
Active, closed
Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People With HIV-1
NCT06630286HIV-1-infection
DrugsISL/LEN·B/F/TAF
Gilead Sciences
Phase 3
609
Berlin, Bonn, Cologne, Essen, Hamburg
2024-10-09
Recruiting
A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT06417814Metastatic Non-small Cell Lung Cancer
DrugsTagrisso·Datopotamab deruxtecan·Osimertinib·Pemetrexed
AstraZeneca
Phase 3
744
Berlin, Berlin-Zehlendorf, Bonn, Essen, Georgsmarienhütte, Giessen, Großhansdorf, Hamburg
2024-10-04
Recruiting
Impact of Different Perioperative Tourniquets on Blood Loss and Surgeon Satisfaction in Total Knee Arthroplasty
NCT06947655Total Knee Arthroplasty
University Hospital, Bonn
Not applicable
50
Bonn
2024-10-01
Recruiting
Real World European Investigation of Safety and Clinical Efficacy of the EVOQUE System (TRISCEND III EU)
NCT06569602Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
Edwards Lifesciences
Observational
500
Bad Berka, Bad Nauheim, Bad Neustadt an der Saale, Bad Oeynhausen, Berlin, Bonn, Dortmund, Essen
2024-10-01
Active, closed
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
NCT06473779Severe Asthma
AstraZeneca
Phase 3
326
Augsburg, Bonn, Cottbus, Hanover, Mainz
2024-09-30
Active, closed
A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
NCT06660394Dravet Syndrome
DrugBexicaserin
Longboard Pharmaceuticals
Phase 3
96
Frankfurt am Main, Bielefeld, Bonn, Kiel, Ravensburg
2024-09-25
Active, closed
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)
NCT06525220Head and Neck Squamous Cell Carcinoma
DrugsPetosemtamab·Pembrolizumab
Merus B.V.
Phase 3
699
Bonn, Dortmund, Dresden, Greifswald, Hamburg, Hanover, Mannheim, München
2024-09-25
Recruiting
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
NCT06635148Geographic Atrophy, Macular Degeneration
Janssen Research & Development, LLC
Phase 2/3
274
Bonn, Göttingen, Hanover, Leipzig, Ludwigshafen am Rhein, Münster, Tübingen
2024-09-19
Recruiting
European Registry of Next Generation Imaging in Advanced Prostate Cancer
NCT06866782Prostate Cancer, Advanced Prostate Cancer, Metastatic Prostate Cancer (mPC)
Fundacio Puigvert
Observational
600
Bonn, Hamburg, Munich, Planegg, Tübingen
2024-09-17
Active, closed
A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis
NCT06431373Uveitis, Posterior, Uveitis, Intermediate, Uveitis
Priovant Therapeutics, Inc.
Phase 3
371
Mannheim, Bonn, Düsseldorf, Münster, Kiel, Mainz
2024-09-11
Recruiting
ATLAS (AltaValve) Pivotal Trial
NCT06465745Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation
4C Medical Technologies, Inc.
Not applicable
450
Berlin, Bonn, Cologne, Dortmund, Mainz, Oeynhausen, Trier, Ulm
2024-09-03
Recruiting
Progression Assessment of PXE-associated Alterations
NCT07048106Pseudoxanthoma Elasticum, Angioid Streaks, Peau d&#39;Orange, Grönblad-Stranberg Disease (Pseudoxanthoma Elasticum)
University Hospital, Bonn
Observational
100
Bonn
2024-09-01
Active, closed
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
NCT06531824Kidney Disease, Chronic
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
11,000
Aachen, Bad Kreuznach, Bad Nenndorf, Bad Oeynhausen, Berlin, Bonn, Braunschweig, Coburg
2024-08-30
Recruiting
Endoscopic Radiofrequency Ablation for Unresectable Cholangiocarcinoma
NCT06175845Cholangiocarcinoma, Klatskin Tumor, Bile Duct Cancer, Liver Cancer
Universitätsklinikum Hamburg-Eppendorf
Not applicable
130
Berlin, Bonn, Chemnitz, Essen, Hamburg, Hanover, Heidelberg, Lübeck
2024-08-30
Recruiting
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study
NCT06574282Hypophosphatasia
University of Bonn
Observational
720
Bonn
2024-08-25
Recruiting
Durvalumab + Intraductal Radiofrequency Ablation (ID-RFA) in Extrahepatic Cholangiocarcinoma
NCT06440993Extrahepatic Cholangiocarcinoma, Unresectable Perihilar or Ductal CCA
DrugsDurvalumab·Gemcitabine·Cisplatin
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 2
42
Aachen, Bonn, Cologne, Düsseldorf, Frankfurt, Göttingen, Hanover, Lübeck
2024-08-23
Recruiting
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
NCT06467357Biliary Tract Cancer
DrugsRilvegostomig·Trastuzumab deruxtecan·Durvalumab·Gemcitabine
AstraZeneca
Phase 3
620
Berlin, Bonn, Cologne, Dresden, Frankfurt, Freiburg im Breisgau, Göttingen, Hamburg
2024-08-12
By invitation
Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia
NCT07259356Hemophilia
University Hospital, Bonn
Not applicable
12
Bonn
2024-08-01
Active, closed
A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)
NCT06510816Geographic Atrophy
DrugVonaprument
Annexon, Inc.
Phase 3
659
Neubrandenburg, Münster, Bonn, Heidelberg, Tübingen
2024-07-30
Recruiting
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
NCT06979323Asthma
DrugDepemokimab
GlaxoSmithKline
Phase 3
150
Bonn, Frankfurt
2024-07-19
Active, closed
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
NCT06455202Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
976
Aachen, Bad Bentheim, Berlin, Bonn, Dresden, Düsseldorf, Essen, Hamburg
2024-07-19
Recruiting
TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias
NCT07798674Hereditary Spastic Paraplegia, Spastic Ataxia
Heidelberg University
Observational
4,000
Bochum, Bonn, Dresden, Erlangen, Essen, Göttingen, Heidelberg, Kiel
2024-07-16
Recruiting
Evaluation of Arthroplasty Treatment
NCT07799818Surgery, Knee Arthropathy, Hip Arthropathy, Prosthetic-joint Infection
University Hospital, Bonn
Observational
300
Bonn
2024-07-01
Recruiting
AI-POD Clinical Validation Study for Obese Patients
NCT06595134Acute Cardiovascular Disease
University Hospital, Bonn
Observational
1,200
Bonn, Mannheim
2024-07-01
Recruiting
Non Interventional German Leptomeningeal Disease Register
NCT06146010Meningeal Neoplasms, Leptomeningeal Disease
University Hospital Tuebingen
Observational
50
Bonn, Mannheim, München, Münster, Siegen, Tübingen, Ulm
2024-06-26
Active, closed
A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis
NCT06425549Moderate to Severe Plaque Psoriasis
DrugsBimekizumab·Ustekinumab
UCB Biopharma SRL
Phase 3
176
Bad Bentheim, Berlin, Bonn, Dresden, Erlangen, Frankfurt am Main, Hamburg, Kiel
2024-06-25
Recruiting
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
NCT06455449Polymyositis, Dermatomyositis
AstraZeneca
Phase 3
240
Bad Nauheim, Berlin, Bonn, Freiburg im Breisgau, Herne, München, Tübingen
2024-06-20
Active, closed
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
NCT06388733Glioblastoma, GBM, Brain Neoplasms, Adult, Malignant, Brain Tumor
DrugsTemodar·Niraparib·Temozolomide
Ivy Brain Tumor Center
Phase 3
450
Heidelberg, Mannheim, Tübingen, Regensburg, Bonn, Chemnitz, Leipzig, Berlin
2024-06-19
Recruiting
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288Heart Failure
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
6,712
Aachen, Bad Friedrichshall, Berlin, Bonn, Dessau, Dresden, Erfurt, Frankfurt
2024-06-17
Recruiting
Long-term Follow-up of Children Born in the PETN Studies
NCT06534307Intrauterine Growth Restriction, Pentaerithrityl Teratnitrate in Pregnancy, Long-Term Effects to Children
Jena University Hospital
Observational
228
Tübingen, Ulm, München, Hanover, Bonn, Dresden, Leipzig, Halle
2024-06-01
Recruiting
Ultra-high-caloric, Fatty Diet in ALS
NCT06280079Amyotrophic Lateral Sclerosis
University of Ulm
Not applicable
392
Aachen, Berlin, Bochum, Bonn, Dresden, Erlangen, Essen, Göttingen
2024-06-01
By invitation
Non-invasive Vagus Nerve Stimulation as a Tool to Modulate Stomach-Brain Coupling in Depression
NCT06389175Depressive Disorder, Major
University of Bonn
Not applicable
80
Bonn
2024-05-21
Active, closed
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
NCT06321302Diabetic Retinopathy
Boehringer Ingelheim
Phase 2
190
Bonn, Mainz, Neubrandenburg, Tübingen, Ulm
2024-05-15
Recruiting
Placebo Optimization of the Presurgical Long-term Video-EEG Monitoring
NCT06383689Symptomatic Epilepsy
University Hospital, Bonn
Not applicable
90
Bonn
2024-05-13
Active, closed
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
NCT06238622Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
DrugNerandomilast
Boehringer Ingelheim
Phase 3
1,666
Ahrensburg, Bamberg, Berlin, Bonn, Coswig, Essen, Hamburg, Hanover
2024-05-06
Recruiting
Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy
NCT05976685Ischemic Stroke, Atrial Fibrillation
DrugDOAC
Insel Gruppe AG, University Hospital Bern
Not applicable
482
Lübeck, Berlin, Bonn, Göttingen, Hamburg, Heidelberg, Leipzig, Mannheim
2024-05-01
Recruiting
BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation
NCT05717192Emphysema or Chronic Obstructive Pulmonary Disease
IHF GmbH - Institut für Herzinfarktforschung
Not applicable
224
Berlin, Bonn, Essen, Halle, Heidelberg, Hemer, Immenhausen, Langen
2024-04-24
Recruiting
Prevalence of Synovitis in Patients With Haemophilia A
NCT06352216Haemophilia A, Synovitis, Hemophilia Arthropathy, Sonography
University Hospital, Bonn
Observational
300
Bonn
2024-04-15
Recruiting
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
NCT06357533Non-Small Cell Lung Cancer
DrugsRilvegostomig·Datopotamab deruxtecan·Keytruda·Pembrolizumab
AstraZeneca
Phase 3
675
Berlin, Bonn, Cologne, Düsseldorf, Essen, Freiburg im Breisgau, Gauting, Georgsmarienhütte
2024-04-11
Recruiting
Cohort Study on Plant-based Diets (COPLANT Study)
NCT06323538Dietary Exposure, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Bone Loss
German Federal Institute for Risk Assessment
Observational
6,000
Karlsruhe, Jena, Berlin, Bonn, Giessen, Heidelberg, Regensburg
2024-04-09
Active, closed
Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly Diagnosed Multiple Myeloma
NCT06216158Multiple Myeloma
DrugsIberdomide·Isatuximab·Dexamethasone
University of Heidelberg Medical Center
Phase 3
411
Aachen, Augsburg, Bad Saarow, Berlin, Bielefeld, Bonn, Braunschweig, Chemnitz
2024-04-05
Recruiting
A LONGITUDINAL OBSERVATIONAL STUDY to EVALUATE the EFFICACY of MOVEMENT and IMPLEMENT CONCRETE MOVEMENT RECOMMENDATIONS with the HELP of MOBILITY TRACKING with SMARTWATCHES in SUBJECTS with AXIAL SPONDYLOARTHRITIS
NCT06807853Axial Spondyloarthritis, Axial Spondyloarthritis (AxSpA), Axial Spondylarthritis (r-axSpA), Axial Spondyloarthopathy
University of Bonn
Observational
50
Bonn
2024-04-01
By invitation
Return to Activity After Total Knee Arthroplasty
NCT07006545Total Knee Arthroplasty
University Hospital, Bonn
Observational
400
Munich, Bonn
2024-04-01
Recruiting
An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene
NCT06435000Stargardt, Stargardt's Disease, Stargardt Disease, STGD1
Splice Bio
Observational
75
Bonn, Tübingen
2024-03-29
Active, closed
REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
NCT06041386Asthma
DrugMepolizumab
GlaxoSmithKline
Phase 4
336
Aachen, Bonn, Darmstadt, Frankfurt, Hohenstein-Ernsttal, Schleswig
2024-03-20
Recruiting
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
NCT05646381Aortic Stenosis
DrugPelacarsen
Novartis Pharmaceuticals
Phase 2
502
Frankfurt am Main, Kaiserslautern, Dresden, Leipzig, Ahaus, Berlin, Bonn, Essen
2024-03-07
Recruiting
Investigation of the Influence of the Human Microbiome on Giant Cell Arteritis
NCT06279065Giant Cell Arteritis
University of Bonn
Observational
50
Bonn
2024-02-29
Recruiting
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
NCT06283966COPD (Chronic Obstructive Pulmonary Disease)
AstraZeneca
Phase 3
5,000
Ahrensburg, Augsburg, Bamberg, Berlin, Bonn, Bremen, Cottbus, Dachau
2024-02-21
Active, closed
A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
NCT06012435Carcinoma, Non-Small-Cell Lung
DrugsSigvotatug vedotin·Docetaxel
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
762
Halle, Bonn, Esslingen am Neckar, Frankfurt a.M., Gauting, Großhansdorf, Heidelberg
2024-02-21
Recruiting
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients
NCT06279793Intensive Care Unit, Coronary Artery Bypass Grafting (CABG), High Risk Patients, Cardiopulmonary Bypass
GCP-Service International West GmbH
Phase 2
550
Augsburg, Berlin, Bonn, Göttingen, Hamburg, Kiel, Mainz, Münster
2024-02-15
Active, closed
Real-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed)
NCT06380738Metastatic Castration-resistant Prostate Cancer
AstraZeneca
Observational
111
Aschaffenburg, Augsburg, Bergisch Gladbach, Berlin, Bonn, Cologne, Dresden, Duisburg
2024-02-14
Recruiting
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
NCT06152575Multiple Myeloma
DrugsElotuzumab·Elranatamab·Carfilzomib·Pomalidomide
Pfizer
Phase 3
492
Freiburg im Breisgau, Stuttgart, Ulm, Nuremberg, Bonn, Berlin, Cottbus, Hamm
2024-02-08
Active, closed
A Study About Antibody Levels and Biomarkers in the Blood in People With Late-onset Pompe Disease
NCT06150820Pompe Disease (Late-onset)
Astellas Gene Therapies
Not applicable
119
Bonn, Essen, Höchheim, Münster
2024-02-01
Active, closed
Early Genetic Identification of Obesity
NCT06239064Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
Rolfs Consulting und Verwaltungs-GmbH (RCV)
Observational
1,000
Aachen, Augsburg, Bad Krozingen, Bielefeld, Bonn, Bückeburg, Cologne, Essen
2024-01-24
Recruiting
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
NCT05970172Chronic Kidney Disease, Renal Anemia
DrugRoxadustat
Astellas Pharma Global Development, Inc.
Phase 3
100
Bonn, Tübingen
2024-01-16
Recruiting
Preventing Gastrointestinal Disturbance in Patients After Longitudinal Laparotomy.
NCT05923086Ileus Postoperative
DrugLidocaine
Orexa BV
Phase 2
126
Bonn, Düsseldorf, Wolfsburg
2024-01-11
Active, closed
Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa
NCT06079281Hypophosphatasia
DrugALXN1850
Alexion Pharmaceuticals, Inc.
Phase 3
124
Bad Reichenhall, Berlin, Bonn, Hamburg, Würzburg
2024-01-03
Recruiting
DragonFly EU Pivotal Study
NCT05927441Mitral Valve Insufficiency
Hangzhou Valgen Medtech Co., Ltd
Not applicable
168
Bonn
2024-01-01
Recruiting
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
NCT06136624Prostate Cancer Metastatic
DrugsFludrocortisone acetate·Opevesostat·Zytiga·Hydrocortisone
Merck Sharp & Dohme LLC
Phase 3
1,310
Munich, Schwerin, Bonn, Münster, Lübeck, Jena, Berlin, Hamburg
2023-12-31
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
NCT06059638Hypertension, Hypertension, Systolic, Hypertension, Essential
Orchestra BioMed, Inc
Not applicable
316
Berlin, Bonn, Frankfurt, Hamburg, Leipzig, Lübeck, Mannheim, Saarbrücken
2023-12-27
Active, closed
A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo
NCT06118411Vitiligo
DrugUpadacitinib
AbbVie
Phase 3
614
Erlangen, Munich, Blankenfelde-Mahlow, Bonn, Frankfurt am Main, Bad Bentheim, Münster, Mainz
2023-12-19
Recruiting
Comparative Effectiveness and Safety of ELIOS in Patients With Open-Angle Glaucoma Undergoing Cataract Surgery
NCT06246136Open Angle Glaucoma
Elios Vision, Inc.
Not applicable
194
Bochum, Bonn, Heidelberg
2023-12-05
Active, closed
Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
NCT06109779Biliary Tract Cancer
DrugsGemcitabine/Cisplatin·Rilvegostomig·Tegafur·Capecitabine
AstraZeneca
Phase 3
760
Berlin, Bonn, Dortmund, Dresden, Erlangen, Esslingen A. N., Frankfurt, Hamburg
2023-12-04
Active, closed
A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2
NCT06072183Stable Nonsegmental Vitiligo, Active Nonsegmental Vitiligo
DrugRitlecitinib
Pfizer
Phase 3
1,571
Darmstadt, Bielefeld, Bochum, Bonn, Mainz, Dresden, Leipzig, Magdeburg
2023-11-08
Recruiting
Oral Pooled Fecal Microbiotherapy to Prevent Allogeneic Hematopoietic Cell Transplantation Complications (PHOEBUS Trial)
NCT05762211Transplant Complication
MaaT Pharma
Phase 2
387
Augsburg, Berlin, Bonn, Essen, Frankfurt, Hombourg, Kiel, Leipzig
2023-10-31
Active, closed
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
NCT05984277Metastatic Non-small Cell Lung Cancer
DrugsVolrustomig·Pemetrexed·Paclitaxel·Carboplatin
AstraZeneca
Phase 3
895
Berlin-Zehlendorf, Bonn, Braunschweig, Dresden, Freiburg im Breisgau, Gauting, Georgsmarienhütte, Gütersloh
2023-10-24
Active, closed
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
NCT06095115Plaque Psoriasis
DrugIcotrokinra
Janssen Research & Development, LLC
Phase 3
684
Bad Bentheim, Berlin, Bonn, Dresden, Dülmen, Düsseldorf, Frankfurt am Main, Freiburg im Breisgau
2023-10-12
Recruiting
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
NCT06079671Locally Advanced Cervical Cancer
DrugVolrustomig
AstraZeneca
Phase 3
800
Berlin, Bonn, Hamburg, Leipzig
2023-09-22
Recruiting
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
NCT06460142Giant Cell Arteritis, Polymyalgia Rheumatica
University of Bonn
Observational
100
Bonn
2023-09-01
Active, closed
The BD Liverty™ TIPS Stent Graft Study
NCT05711316Portal Hypertension, TIPS
C. R. Bard
Not applicable
177
Berlin, Bonn, Dresden, Frankfurt, Hanover, Münster
2023-08-08
Recruiting
Brain and Voice Signatures in Teachers
NCT06126627Voice Disorders, Voice Fatigue
University Hospital, Bonn
Not applicable
100
Bonn
2023-08-01
Active, closed
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
NCT05851443Moderate to Severe Asthma
DrugsICS/LABA·Povorcitinib
Incyte Corporation
Phase 2
247
Bendorf, Bonn, Frankfurt am Main, Hanover, Mainz
2023-07-11
Recruiting
Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study
NCT05851209Aortic Stenosis, Imaging, Pathogenesis, Disease Progression
Heinrich-Heine University, Duesseldorf
Observational
938
Bonn, Cologne, Düsseldorf
2023-07-01
Recruiting
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
NCT06016946Friedreich Ataxia
Friedreich's Ataxia Research Alliance
Observational
3,000
Aachen, Bonn, Munich, Tübingen
2023-06-28
Recruiting
An Observational Cohort Study to Characterize the Effectiveness and Safety of HEMGENIX® in Patients With Hemophilia B
NCT06008938Hemophilia B
CSL Behring
Observational
500
Berlin, Bonn, Frankfurt, Hanover
2023-06-15
Recruiting
Patient-reported, Health Economic and Psychosocial Outcomes in Friedreich Ataxia
NCT05943002Friedreich Ataxia
German Center for Neurodegenerative Diseases (DZNE)
Observational
200
Aachen, Bonn, Münich, Tübingen
2023-06-01
Active, closed
Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab
NCT05626855Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type 2, SMA
DrugApitegromab
Scholar Rock, Inc.
Phase 3
238
Bonn, Essen, Freiburg im Breisgau, Munchen, Bayern
2023-04-17
Recruiting
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
NCT05774951Breast Cancer, Early Breast Cancer
DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole
AstraZeneca
Phase 3
4,300
Aachen, Augsburg, Bayreuth, Berlin, Bonn, Deggendorf, Dessau, Dresden
2023-03-31
Recruiting
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
NCT05259605Glioma, Glioneuronal Tumor, Choroid Plexus Tumor, Pineal Tumors
European Organisation for Research and Treatment of Cancer - EORTC
Observational
1,650
Bochum, Bonn, Cologne, Essen, Frankfurt, Jena, Leipzig, Regensburg
2023-03-21
Active, closed
Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
NCT05445778Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
DrugsMirvetuximab Soravtansine·Bevacizumab
AbbVie
Phase 3
520
Esslingen am Neckar, Heidelberg, Erlangen, Giessen, Bielefeld, Bonn, Dortmund, Mainz
2023-03-15
Active, closed
DOR/ISL in HIV-1 Antiretroviral Treatment-naïve Participants (MK-8591A-053)
NCT05705349HIV-1 Infection
DrugsDOR/ISL·B/F/TAF
Merck Sharp & Dohme LLC
Phase 3
537
München, Freiburg, Bonn, Hamburg
2023-03-08
Recruiting
A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis
NCT06875336Extrapulmonary Tuberculosis
University of Cologne
Observational
150
Bonn, Borstel, Cologne, Frankfurt, Hamburg, Heidelberg
2023-03-06
Recruiting
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
NCT05656469Mood Disorders, Anxiety Disorders, Psychotic Disorders
Parnassia Groep
Not applicable
2,500
Bonn, München
2023-02-23
Active, closed
A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
NCT04808245Newly Diagnosed H3-mutated Glioma
DrugsTecentriq·Atezolizumab
German Cancer Research Center
Phase 1
15
Heidelberg, Mannheim, Tübingen, Frankfurt am Main, Bonn, Essen, Dresden, Berlin
2023-02-15
Recruiting
A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
NCT05822908Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 3, Huntington Disease
Vico Therapeutics B. V.
Phase 1/2
68
Bochum, Bonn, Essen, Tübingen
2023-02-14
Active, closed
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
NCT05685238Haemophilia A, Haemophilia A With Inhibitors
Novo Nordisk A/S
Phase 3
451
Berlin, Bonn, Frankfurt am Main
2023-02-13
Recruiting
Treatment of Non-resectable Bile Duct Cancer with Radiofrequency Ablation or Photodynamic Therapy
NCT05551299Hilar Cholangiocarcinoma
University of Leipzig
Phase 4
258
Aachen, Augsburg, Berlin, Bonn, Frankfurt, Freiburg im Breisgau, Greifswald, Halle
2023-02-10
Active, closed
Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
NCT05605899High-risk Large B-cell Lymphoma (LBCL)
DrugsAxi-cel·Axicabtagene Ciloleucel·Vincristine·Doxorubicin
Kite, A Gilead Company
Phase 3
300
Berlin, Bonn, Düsseldorf, Erlangen
2023-02-10
Recruiting
Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial
NCT05496998Mitral Regurgitation
Medtronic Cardiovascular
Not applicable
400
Bad Oeynhausen, Berlin, Bonn, Hamburg, Leipzig, Mainz, München, Ulm
2023-02-07
Active, closed
GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
NCT05686551Huntington Disease
Hoffmann-La Roche
Phase 2
301
Aachen, Berlin, Bochum, Bonn, Erlangen, Lübeck, Taufkirchen, Ulm
2023-02-03
Active, closed
Registry on Percutaneous Electrochemotherapy
NCT05267080Primary Liver Cancer, Secondary Liver Cancer
Cardiovascular and Interventional Radiological Society of Europe
Observational
250
Bonn, Braunschweig, Halle, Leipzig, Regensburg
2023-01-25
Recruiting
REscue Stenting With CREDO® Heal for Recanalisation After Unsuccessful Thrombectomy (RECHRUT)
NCT05345483Rescue Stenting
Acandis GmbH
Observational
153
Aschaffenburg, Augsburg, Bonn, Bremerhaven, Dresden, Duisburg, Erfurt, Halle
2023-01-25
Recruiting
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
NCT05580562H3 K27M, Glioma
DrugDordaviprone
Jazz Pharmaceuticals
Phase 3
510
Heidelberg, Augsburg, Regensburg, Frankfurt am Main, Bonn, Cologne, Essen, Berlin
2023-01-23
Active, closed
Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
NCT05526560Mitral Stenosis, Mitral Valve Insufficiency
Edwards Lifesciences
Observational
504
Augsburg, Bad Neustadt an der Saale, Bad Oeynhausen, Bonn, Bremen, München
2023-01-11
Recruiting
Nivolumab in Children and Adults With Nasopharyngeal Carcinoma
NCT06019130Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Nasopharyngeal Neoplasms, Nasopharynx Cancer
DrugsAvonex·Opdivo·Adrucil·Nivolumab
German Society for Pediatric Oncology and Hematology GPOH gGmbH
Phase 2
57
Aachen, Berlin, Bielefeld, Bonn, Cologne, Cottbus, Dortmund, Dresden
2023-01-10
By invitation
A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401)
NCT05768386Hemophilia A
BioMarin Pharmaceutical
Observational
172
Bonn, Berlin
2023-01-01
Active, closed
A Study Evaluating the Safety and Tolerability of QRL-201 in ALS
NCT05633459Amyotrophic Lateral Sclerosis
QurAlis Corporation
Phase 1
69
Bonn, Berlin, Lübeck, Ulm
2022-12-16
Recruiting
Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia
NCT05327894Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia
DrugBlinatumomab
Princess Maxima Center for Pediatric Oncology
Phase 3
160
Augsburg, Berlin, Bonn, Dortmund, Dresden, Erlangen, Giessen, Halle
2022-12-15
Active, closed
TARGET Study: Safety and Performance of the Cardiovalve TR Replacement System
NCT05486832Tricuspid Regurgitation
Cardiovalve Ltd.
Not applicable
157
Bad Oeynhausen, Berlin, Bonn, Cologne, Hamburg, Lübeck, Regensburg
2022-12-09
Recruiting
GMMG Multiple Myeloma Registry
NCT07111884Multiple Myeloma
Prof. Dr. Hartmut Goldschmidt
Observational
999
Berlin, Bielefeld, Bochum, Bonn, Chemnitz, Cologne, Darmstadt, Düsseldorf
2022-12-08
Active, closed
Dazucorilant in Patients With Amyotrophic Lateral Sclerosis
NCT05407324Amyotrophic Lateral Sclerosis
Corcept Therapeutics
Phase 2
279
Berlin, Bonn, Dresden, Hanover, Jena, München, Rostock, Ulm
2022-11-15
Recruiting
Further Evaluation of Safety and Performance of the NEXUS Aortic Arch Stent Graft System and the Custom-Made NEXUS Multibranch™ Aortic Arch Stent Graft System
NCT05636527AAT9
Endospan Ltd.
Observational
70
Bernau bei Berlin, Düsseldorf, Berlin, Bonn
2022-11-09
Recruiting
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
NCT05457283Chronic Kidney Disease, Proteinuria, Children
DrugFinerenone
Bayer
Phase 3
100
Heidelberg, Hanover, Bonn, Essen, Münster, Berlin, Hamburg
2022-11-08
Active, closed
A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp
NCT05387525Keratosis, Actinic
DrugDiclofenac Sodium
Almirall, S.A.
Phase 4
447
Augsburg, Bad Bentheim, Bochum, Bonn, Detmold, Dresden, Erlangen, Hamburg
2022-10-24
Active, closed
Neurodevelopmental Impact of Epilepsy on Autonomic Function in Dravet Syndrome
NCT05472389Dravet Syndrome, Epilepsy
Hospices Civils de Lyon
Not applicable
92
Bonn
2022-10-14
Active, closed
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
NCT05587296Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
Bayer
Phase 3
474
Mannheim, Tübingen, Frankfurt am Main, Hanover, Aachen, Bergisch Gladbach, Bonn, Essen
2022-10-14
Active, closed
The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events
NCT05421286HIV-1-infection, Inflammation, AIDS
Rigshospitalet, Denmark
Observational
991
Bonn, Cologne, Eppendorf, Frankfurt am Main, Hamburg
2022-09-28
Recruiting
Efficacy of Luspatercept in ESA-naive LR-MDS Patients With or Without Ring Sideroblasts Who do Not Require Transfusions
NCT05384691Myelodysplastic Syndromes, Anemia
DrugLuspatercept
University of Leipzig
Phase 2
213
Berlin, Bonn, Cottbus, Erlangen, Greifswald, Hamburg, Kassel, Koblenz
2022-09-27
Recruiting
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT05519085Relapsed or Refractory Multiple Myeloma
DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib
Celgene
Phase 3
810
München, Traunstein, Weiden, Marburg, Hanover, Bonn, Düsseldorf, Kiel
2022-09-20
Active, closed
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma
NCT05409066Follicular Lymphoma (FL)
DrugsEpcoritamab·Lenalidomide·Rituximab
Genmab
Phase 3
549
Tübingen, Würzburg, Giessen, Kassel, Göttingen, Bonn, Dresden, Leipzig
2022-09-20
Recruiting
Phase III Study of Induction and Consolidation Chemotherapy With Venetoclax in Patients With Newly Diagnosed AML or MDS-EB-2
NCT04628026Acute Myeloid Leukemia
DrugVenetoclax
University of Ulm
Phase 3
650
Aschaffenburg, Bad Saarow, Berlin, Bochum, Bonn, Braunschweig, Bremen, Darmstadt
2022-09-13
Recruiting
Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma
NCT05564091Primary Open Angle Glaucoma
Nova Eye, Inc.
Not applicable
78
Bonn, Cologne, Dortmund
2022-09-08
By invitation
Outcome of Patients With Severe Functional TR According to Medical, Transcatheter or Surgical Treatment
NCT05825898Tricuspid Regurgitation
Ottawa Heart Institute Research Corporation
Observational
3,500
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Leipzig, Mainz
2022-09-01
Active, closed
A Study to Learn About the Safety of Diranersen (BIIB080) Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age
NCT05399888Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia
Biogen
Phase 2
416
Mannheim, Tübingen, Ulm, Bayreuth, München, Erbach im Odenwald, Göttingen, Bonn
2022-08-24
Recruiting
Resuscitation Registry in CHD
NCT05373498Cardiac Arrest, Congenital Heart Disease
Leipzig Heart Science gGmbH
Observational
400
Leipzig, Berlin, Bonn
2022-08-18
Active, closed
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen
NCT05502341HIV-1-infection
DrugsBictegravir·Lenacapavir
Gilead Sciences
Phase 2/3
689
Berlin, Bonn, Frankfurt, Hamburg, München
2022-08-16
Active, closed
A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow
NCT05330325SGA, Turner Syndrome, Noonan Syndrome, ISS
DrugsNorditropin·Somapacitan
Novo Nordisk A/S
Phase 3
412
Bonn, Erlangen, Frankfurt am Main, Homburg
2022-08-10
Active, closed
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
NCT05382286Triple Negative Breast Cancer, PD-L1 Positive
DrugsAbraxane·Sacituzumab Govitecan·Taxol·Nab-paclitaxel
Gilead Sciences
Phase 3
443
Berlin, Bonn, Bottrop, Cologne, Erlangen, Essen, Freiburg im Breisgau, Hamburg
2022-07-25
Recruiting
Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy
NCT05442710Sepsis, Severe
Artcline GmbH
Phase 2
142
Freiburg im Breisgau, Regensburg, Bonn, Cologne, Aue, Leipzig, Halle, Kiel
2022-07-24
Active, closed
Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
NCT05382299Triple Negative Breast Cancer, PD-L1 Negative
DrugsAbraxane·Sacituzumab Govitecan·Nab-paclitaxel·Gemcitabine
Gilead Sciences
Phase 3
623
Berlin, Bonn, Cologne, Essen, Hamburg, Heidelberg, Lübeck, Mannheim
2022-07-20
Recruiting
Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery
NCT04918173Congenital Antithrombin Deficiency
Octapharma
Phase 3
38
Berlin, Bonn, Duisburg
2022-07-01
Active, closed
A Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants With Severe or Moderate Hemophilia A Without Factor VIII Inhibitors on Emicizumab Prophylaxis
NCT05181618Severe Hemophilia A, Moderate Hemophilia A
DrugEmicizumab
Hoffmann-La Roche
Phase 4
136
Berlin, Bonn
2022-06-20
Active, closed
An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration
NCT05300724Age-Related Macular Degeneration
Genentech, Inc.
Observational
400
Bonn, Freiburg im Breisgau, Göttingen, Hanover, Leipzig, Münster, Tübingen
2022-05-27
Active, closed
A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)
NCT05374512Breast Cancer
DrugsEribulin·Datopotamab deruxtecan·Nab-paclitaxel·Capecitabine
AstraZeneca
Phase 3
644
Aschaffenburg, Bonn, Frankfurt am Main, Georgsmarienhütte, Hanover, Heilbronn, Koblenz Am Rhein, Langen
2022-05-16
Active, closed
Evolut™ EXPAND TAVR II Pivotal Trial
NCT05149755Moderate Aortic Valve Stenosis
Medtronic Cardiovascular
Not applicable
650
Bad Krozingen, Bonn, Dortmund, Leipzig, Mainz, München
2022-04-27
Recruiting
Combination of Abemaciclib and Endocrine Therapy in Hormone Receptor Positive HER2 Negative Locally Advanced or Metastatic Breast Cancer With Focus on Digital Side Effect Management
NCT05362760Hormone Receptor-positive Metastatic Breast Cancer, HER2-negative Metastatic Breast Cancer
DrugsAbemaciclib·Fulvestrant
Prof. Wolfgang Janni
Phase 4
300
Aalen, Amberg, Aschaffenburg, Augsburg, Berlin, Biberach, Bonn, Braunschweig
2022-04-27
Active, closed
Treatment of Atezolizumab and Derazantinib in Patients With Advanced iCCA With FGFR2 Fusions/Rearrangements
NCT05174650Intrahepatic Cholangiocarcinoma
DrugsTecentriq·Atezolizumab
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 2
27
Bad Saarow, Berlin, Bonn, Cologne, Esslingen am Neckar, Frankfurt, Hanover, Krefeld
2022-04-20
Active, closed
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
NCT05196035Chronic Kidney Disease, Proteinuria
DrugFinerenone
Bayer
Phase 3
219
Heidelberg, Hanover, Bonn, Essen, Münster, Berlin, Hamburg
2022-03-28
Active, closed
Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC
NCT05301842Hepatocellular Carcinoma
DrugsTremelimumab·Lenvatinib·Durvalumab
AstraZeneca
Phase 3
760
Bonn, Chemnitz, Dresden, Düsseldorf, Frankfurt, Göttingen, Hamburg, Hanover
2022-03-28
Active, closed
TRICuspid Intervention in Heart Failure Trial
NCT04634266Heart Failure Attributable to Severe Tricuspid Regurgitation
LMU Klinikum
Not applicable
360
Bad Oeynhausen, Berlin, Bernau, Bonn, Bremen, Cologne, Dortmund, Düsseldorf
2022-03-25
Active, closed
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
NCT05239728Carcinoma, Renal Cell
DrugsBelzutifan·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,800
Singen, Tübingen, Munich, Aachen, Bonn, Düsseldorf, Essen, Münster
2022-03-15
Recruiting
Acute Effects of Physical Exercise in Patients with Borderline Personality Disorder
NCT05246527Borderline Personality Disorder
University Hospital, Bonn
Not applicable
120
Bonn
2022-02-08
Active, closed
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
NCT05173987Endometrial Neoplasms
DrugsTaxotere·Paraplatin·Taxol·Docetaxel
Merck Sharp & Dohme LLC
Phase 3
280
Ulm, Bonn, Dresden, Berlin
2022-02-03
Active, closed
Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
NCT05407636AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
DrugsEylea·Aflibercept
AbbVie
Phase 3
735
Freiburg im Breisgau, Ulm, Bonn, Münster, Ludwigshafen am Rhein, Hamburg, Püttlingen
2022-01-13
Active, closed
An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.
NCT05217628Trigeminal Neuralgia
Noema Pharma AG
Phase 2/3
166
Bonn
2022-01-11
Active, closed
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
NCT04905069Prostate Cancer
Boston Scientific Corporation
Not applicable
500
Bonn, Nuremberg
2021-12-21
Active, closed
Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE
NCT04919226Neuroendocrine Tumors
DrugsFOLFOX (Folinic acid·Everolimus·Fluorouracil·Oxaliplatin
ITM Solucin GmbH
Phase 3
259
Berlin, Bonn, Erlangen, Essen
2021-12-21
Recruiting
RFC1 Natural History Study
NCT05177809Ataxia
Prof. Dr. Matthis Synofzik
Observational
150
Tübingen, Bonn, Lübeck
2021-12-14
Active, closed
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
NCT05116189Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
DrugsDocetaxel·Paclitaxel·Bevacizumab·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
643
Erlangen, Bonn, Düsseldorf, Krefeld, Saarbrücken, Dresden, Leipzig, Berlin
2021-12-13
Recruiting
Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)
NCT05008809Colorectal Cancer
DrugsMFOLFOXIRI·MFOLFOX6·Folfiri·Folfox
Dominik Paul Modest
Phase 3
507
Amberg, Bad Saarow, Bayreuth, Berlin, Bochum, Bonn, Bremen, Chemnitz
2021-12-06
Recruiting
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
NCT04996433Persistent Depressive Disorder, Treatment-resistant Depression
University of Greifswald
Not applicable
396
Berlin, Bonn, Hanover, Jena, Lübeck, Marburg, München, Tübingen
2021-12-01
Active, closed
Low-dose Atropine for Myopia Control in Children
NCT03865160Myopia, Progressive
DrugAtropine eye
University Eye Hospital, Freiburg
Phase 2/3
302
Ahaus, Bonn, Cologne, Erlangen, Essen, Freiburg im Breisgau, Göttingen, Hamburg
2021-10-19
Recruiting
Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)
NCT05112549Leptomeningeal Disease
DrugsOpdivo·Nivolumab
University Hospital Tuebingen
Phase 1
46
Bonn, Freiburg im Breisgau, Heidelberg, Heilbronn, Mannheim, München, Stuttgart, Tübingen
2021-10-12
Recruiting
Immunophenotyping in Patients With Osteoporosis
NCT05132348Immunophenotyping Blood Samples of Patients With Osteoporosis
University Hospital, Bonn
Observational
250
Bonn
2021-10-10
Active, closed
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
NCT04909801Rheumatoid Arthritis
DrugsAbatacept·Humira·Adalimumab·Methotrexate
Bristol-Myers Squibb
Phase 3
338
Berlin, Bonn, Freiburg im Breisgau, Hamburg, Planegg
2021-09-15
By invitation
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
NCT04957719Acute Myocardial Infarction
Viatris Innovation GmbH
Phase 3
25,000
Bad Krozingen, Bad Oeynhausen, Berlin, Bonn, Cologne, Dortmund, Dresden, Hamburg
2021-08-14
Recruiting
European Disease Registry on Retinopathy of Prematurity (ROP)
NCT04939571Retinopathy of Prematurity
University Medicine Greifswald
Observational
3,000
Aachen, Berlin, Bonn, Braunschweig, Chemnitz, Cologne, Cottbus, Düsseldorf
2021-08-06
Active, closed
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
NCT04790370Pulmonary Embolism
Boston Scientific Corporation
Phase 4
544
Aachen, Bielefeld, Bonn, Chemnitz, Freiburg im Breisgau, Immenstädt, Lübeck, Mainz
2021-08-02
Active, closed
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 6 and 17 Years With Moderate to Severe Plaque Psoriasis Treated With Subcutaneous (SC) Injection of Risankizumab Who Have Completed Participation in Study M19-977
NCT04862286Psoriasis
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
132
Bad Bentheim, Bonn, Münster, Mainz, Dresden, Kiel
2021-07-24
Recruiting
German Cardiac Arrest Registry
NCT05142124Out-of-hospital Cardiac Arrest
Leipzig Heart Science gGmbH
Observational
400
Berlin, Bad Friedrichshall, Bonn, Bremen, Cologne, Dresden, Düsseldorf, Essen
2021-07-21
Recruiting
The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial
NCT04284839Bleeding Post Cardiac Surgery, Indication for Anticoagulation
DrugsDOAC·Dabigatran·Edoxaban·Warfarin
Population Health Research Institute
Phase 3
3,500
Leipzig, Jena, Bonn, Essen, Hamburg
2021-07-18
Active, closed
A Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Velodrome)
NCT04657289Neovascular Age-related Macular Degeneration (nAMD)
DrugRanibizumab
Hoffmann-La Roche
Phase 3
451
Bonn, Cologne, Cottbus, Freiburg im Breisgau, Hamburg, Ludwigshafen, München, Münster
2021-07-14
Active, closed
Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.
NCT05018286Short Bowel Syndrome
DrugApraglutide
VectivBio AG
Phase 3
158
Berlin, Bonn, Hamburg, Heidelberg, Münster
2021-07-13
Active, closed
Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
NCT04964934ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Ribociclib·Abemaciclib
AstraZeneca
Phase 3
315
Ansbach, Augsburg, Bonn, Chemnitz, Dresden, Erlangen, Essen, Freiburg im Breisgau
2021-06-30
Recruiting
WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)
NCT04701684Stroke, Acute
Philips Clinical & Medical Affairs Global
Not applicable
594
Bonn, Kassel, Lübeck, Munich
2021-06-23
Active, closed
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
NCT04895358Breast Neoplasms
DrugsLiposomal doxorubicin·Xeloda·Abraxane·Taxol
Merck Sharp & Dohme LLC
Phase 3
342
Erlangen, Bonn, Düsseldorf, Essen, Dresden, Berlin
2021-06-18
Active, closed
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092Diffuse Large B-cell Lymphoma
DrugsTafasitamab·Vincristine·Doxorubicin·Prednisone
Incyte Corporation
Phase 3
899
Aachen, Augsburg, Berlin, Bonn, Chemnitz, Cottbus, Göttingen, Halle
2021-05-11
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
NCT04873362Breast Cancer
DrugsTrastuzumab emtansine·Herceptin·Tecentriq·Trastuzumab
Hoffmann-La Roche
Phase 3
1,188
Augsburg, Bad Nauheim, Berlin, Bonn, Bottrop, Dessau, Düsseldorf, Erfurt
2021-05-04
Active, closed
Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation
NCT04818502Mitral Valve Regurgitation
Abbott Medical Devices
Observational
200
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Kiel, Leipzig
2021-05-04
Recruiting
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
NCT04752774Spasticity
DrugsDysport·Corabotase
Ipsen
Phase 1/2
240
Bonn, Düsseldorf, Goettigen, Hamburg, Mainz, Munich, Troisdorf, Tübingen
2021-04-29
Recruiting
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
NCT04663750Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
King's College Hospital NHS Trust
Phase 3
210
Bonn, Hamburg, Ludwigshafen, München, Münster, Sulzbach, Ulm, Würzburg
2021-04-16
Recruiting
Tendyne European Experience Registry
NCT04898335Mitral Regurgitation
LMU Klinikum
Observational
400
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Leipzig, Mainz
2021-04-15
Recruiting
Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD
NCT04580420Primary Hyperoxaluria Type 1, End Stage Renal Disease
DrugDcr-Phxc
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Phase 2
28
Bonn, Heidelberg
2021-04-15
Active, closed
Plasmafit® Revision Structan® Hip Endoprosthesis Cup
NCT04255966Osteolysis, Arthroplasty Complications, Instability of Prosthetic Joint, Degenerative Osteoarthritis
Aesculap AG
Observational
60
Würzburg, Braunschweig, Bonn, Homburg
2021-04-12
Active, closed
TRISCEND II Pivotal Trial
NCT04482062Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
Edwards Lifesciences
Not applicable
864
Bad Oeynhausen, Bonn, Cologne, Dresden, Leipzig, Mainz, München
2021-04-09
Recruiting
A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas).
NCT05331521Oligodendroglioma
DrugProcarbazine
University Hospital Heidelberg
Phase 3
406
Heidelberg, Berlin, Bochum, Bonn, Chemnitz, Cologne, Düsseldorf, Frankfurt
2021-04-07
Active, closed
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181Non-alcoholic Steatohepatitis
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,205
Berlin, Bochum, Bonn, Frankfurt, Hanover, Leipzig, Lübeck, Magdeburg
2021-04-01
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
BioNTech SE
Phase 2
327
Berlin, Bochum, Bonn, Frankfurt am Main, Halle, Hamburg, Hanover, Heidelberg
2021-03-08
Active, closed
Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A
NCT04644575Hemophilia A
DrugEfanesoctocog alfa
Bioverativ, a Sanofi company
Phase 3
261
Berlin, Bonn, Frankfurt am Main, München
2021-02-23
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
DrugsAdagrasib·Taxotere·Docetaxel
Mirati Therapeutics Inc.
Phase 3
453
Bad Berka, Bonn, Cologne, Essen, Gauting, Giessen, Grohansdorf, Halle
2021-02-23
Recruiting
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
NCT04545502Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
Vascutek Ltd.
Observational
2,000
Berlin, Bonn, Freiburg im Breisgau, Hamburg, Leipzig, Mainz, Munich
2021-02-17
Active, closed
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors
NCT04431726Severe Hemophilia A
DrugEmicizumab
Hoffmann-La Roche
Phase 3
55
Bonn, Mörfelden-Walldorf
2021-02-04
Active, closed
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
NCT04657991Melanoma
DrugsBinimetinib·Encorafenib·Keytruda·Pembrolizumab
Pfizer
Phase 3
257
Tübingen, München, Bonn, Minden, Mainz, Dresden, Leipzig, Kiel
2021-01-15
Active, closed
Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System
NCT04614402Tricuspid Valve Insufficiency
Edwards Lifesciences
Observational
300
Tübingen, Ulm, München, Cologne, Essen, Bad Oeynhausen, Bonn, Leipzig
2021-01-15
Active, closed
A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)
NCT04204616Prurigo Nodularis
DrugNemolizumab
Galderma R&D
Phase 3
500
Aachen, Augsburg, Bad Bentheim, Berlin, Bonn, Darmstadt, Dresden, Düsseldorf
2021-01-11
Active, closed
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
NCT04634877Endometrial Neoplasms
DrugsDocetaxel·Keytruda·Paclitaxel·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
990
Heilbronn, Ludwigsburg, Tübingen, Hanover, Bonn, Essen, Dresden, Lübeck
2021-01-10
Recruiting
Effect of Fetal Aortic Valvuloplasty on Outcomes
NCT05386173Congenital Heart Disease, Aortic Valve Stenosis, Fetal Cardiac Disorder, Hypoplastic Left Heart Syndrome
Queen Silvia Children's Hospital, Gothenburg, Sweden
Observational
200
Bonn, Heidelberg, Munich
2021-01-01
Recruiting
Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
NCT04678583Colorectal Liver Metastasis
Technische Universität Dresden
Not applicable
240
Mannheim, Dresden, Ansbach, Augsburg, Berlin, Bonn, Braunschweig, Dachau
2021-01-01
Recruiting
Non-invasive Evaluation of the Predictive Value of CEUS and SWE in ACLF, Renal Failure and Hepatorenal Syndrome
NCT04446858Kidney Failure, Acute
University Hospital, Bonn
Observational
1,000
Bonn
2021-01-01
Active, closed
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
NCT04663308Primary Sclerosing Cholangitis
DrugVolixibat
Mirum Pharmaceuticals, Inc.
Phase 2
182
Hanover, Bonn, Berlin, Erlangen, Kiel, Leipzig, Magdeburg, Tübingen
2020-12-18
Active, closed
WATER III: Aquablation vs. Transurethral Laser Enucleation of Large Prostates (80 - 180mL) in Benign Prostatic Hyperplasia
NCT04801381BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
University of Bonn
Not applicable
202
Freiburg im Breisgau, Bochum, Bonn
2020-12-16
Active, closed
Durvalumab and Tremelimumab in Combination With Y-90 SIRT for Intermediate Stage HCC
NCT04522544Hepatocellular Carcinoma Non-resectable, HCC
DrugsTremelimumab·Durvalumab
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Phase 2
55
Bonn, Cologne, Essen, Göttingen, Hanover, Jena, Lübeck, München
2020-12-15
Active, closed
Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy
NCT04655976Lung Cancer, Non-Small Cell
DrugsCobolimab·Dostarlimab·Docetaxel
GlaxoSmithKline
Phase 2/3
758
Augsburg, Bad Berka, Berlin, Bonn, Cologne, Dresden, Essen, Frankfurt
2020-12-08
Active, closed
Restoration of Central Vision With the PRIMA System in Patients With Atrophic AMD
NCT04676854Geographic Atrophy
Science Corporation
Not applicable
38
Aachen, Bonn, Hamburg, Ludwigshafen am Rhein, Lübeck, Munich, Münster, Sulzbach
2020-11-24
Recruiting
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
NCT04688190Mitral Regurgitation, Mitral Valve Disease, Mitral Annular Calcification
Universitätsklinikum Hamburg-Eppendorf
Observational
1,000
Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg, Lübeck, Mainz
2020-11-01
Active, closed
First-line Palbociclib and Endocrine Therapy for Patients With HR+/HER2- Advanced Breast Cancer in the Real-world Setting.
NCT04767594Breast Neoplasms
DrugPalbociclib
Pfizer
Observational
1,407
Bayreuth, Nuremberg, Cottbus, Goslar, Bonn, Bad Mergentheim, Berlin, Bremen
2020-10-27
By invitation
A Study Following Males With Haemophilia A on Prophylaxis With Esperoct®
NCT04574076Haemophilia A
DrugTuroctocog alfa pegol
Novo Nordisk A/S
Observational
60
Berlin, Bonn
2020-10-23
Active, closed
Pulmonary Artery Sensor System Pressure Monitoring to Improve Heart Failure (HF) Outcomes
NCT04398654Heart Failure
IHF GmbH - Institut für Herzinfarktforschung
Not applicable
554
Bad Friedrichshall, Bad Nauheim, Bad Oeynhausen, Berlin, Bielefeld, Bonn, Coburg, Dortmund
2020-10-02
Recruiting
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
NCT04578301Liver Cirrhosis, Portal Hypertension, Surgery, Acute-On-Chronic Liver Failure
University Hospital, Bonn
Observational
200
Bonn
2020-09-22
Recruiting
BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours
NCT04421820Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma
DrugsBOLD-100·Oxaliplatin
Bold Therapeutics, Inc.
Phase 1/2
220
Bonn, Ulm
2020-08-28
Active, closed
An Observational Real-world Study Evaluating Severe Tricuspid Regurgitation Patients Treated With the Abbott TriClip™ Device (bRIGHT)
NCT04483089Tricuspid Valve Regurgitation
Abbott Medical Devices
Observational
511
Bonn, Mainz, Leipzig, Bad Berka, Bad Oeynhausen, Bad Rothenfelde, Berlin, Dortmund
2020-08-27
Recruiting
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)
NCT04419649Myelodysplastic Syndromes, Cytopenia
DrugElritercept
Takeda
Phase 2
160
Bayreuth, Berlin, Bonn, Düsseldorf, Esslingen am Neckar, Halle, Leipzig, Mainz
2020-08-19
Recruiting
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
NCT04307576Leukemia, Acute Lymphoblastic
DrugsInotuzumab Ozogamicin·Imatinib·Blinatumomab
Mats Heyman
Phase 3
6,430
Bielefeld, Bonn, Bremen, Hamburg, Krefeld, Mainz
2020-07-13
Active, closed
A Long-term Study of ADYNOVI/ADYNOVATE in Participants With Haemophilia A
NCT04158934Hemophilia A
Baxalta now part of Shire
Observational
207
Heidelberg, Berlin, Bonn, Hanover
2020-07-09
Active, closed
Amplatzer Amulet LAAO vs. NOAC
NCT04226547Atrial Fibrillation, Stroke, Bleeding
DrugNOAC
Abbott Medical Devices
Not applicable
2,650
Berlin, Lübeck, Bad Segeberg, Bonn, Frankfurt, Giessen, Mainz, Munich
2020-07-07
Active, closed
A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.
NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma
DrugTazemetostat
Epizyme, Inc.
Phase 3
599
Schwäbisch Hall, München, Mainz, Bonn, Mönchengladbach, Kiel, Berlin
2020-06-11
Recruiting
Non-invasive Evaluation Program for TIPS and Follow Up Network 2 (NEPTUN2)
NCT04393519Portal Hypertension
University Hospital, Bonn
Observational
1,000
Bonn
2020-05-12
Active, closed
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
NCT04269200Endometrial Neoplasms
DrugsOlaparib·Durvalumab·Paclitaxel·Carboplatin
AstraZeneca
Phase 3
805
Bonn, Chemnitz, Dresden, Leipzig
2020-05-05
Recruiting
Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System
NCT04190602Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency, Mitral Valve Prolapse
NeoChord
Observational
500
Bonn, Frankfurt, Mainz
2020-02-09
Recruiting
Slow Heart Registry of Fetal Immune-mediated High Degree Heart Block
NCT04559425Heart Block Complete, Heart Block Second Degree
DrugDexamethasone
The Hospital for Sick Children
Observational
350
Bonn
2020-01-01
Active, closed
Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis
NCT03989206Moderate-to-Severe Atopic Dermatitis
DrugNemolizumab
Galderma R&D
Phase 3
1,700
Aachen, Augsburg, Bad Bentheim, Berlin, Bielefeld, Bonn, Buxtehude, Darmstadt
2019-12-30
Active, closed
A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy
NCT04027309Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
DrugsMidostaurin·Gilteritinib
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
777
Aschaffenburg, Bad Saarow, Berlin, Bochum, Bonn, Braunschweig, Bremen, Darmstadt
2019-12-20
Recruiting
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis
NCT03969329Secondary Hyperparathyroidism
DrugEtelcalcetide
Amgen
Phase 3
24
Bonn, Cologne, Hamburg, Hanover, Heidelberg
2019-12-20
Active, closed
Copanlisib and Rituximab in Marginal Zone Lymphoma Patients
NCT03474744Marginal Zone Lymphoma
DrugsCopanlisib Hydrochloride·Truxima·Rituximab
Christian Buske
Phase 2
36
Bochum, Bonn, Dingolfing, Goch, Goslar, Halle, Kassel, Landshut
2019-12-15
Recruiting
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
NCT04045665Atrial Fibrillation, Stroke, Bleeding
Icahn School of Medicine at Mount Sinai
Phase 3
3,200
Berlin, Göttingen, Jena, Bad Nauheim, Bad Neustadt an der Saale, Bad Oeynhausen, Bonn, Braunschweig
2019-12-13
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
NCT04082429Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors
DrugConcizumab
Novo Nordisk A/S
Phase 3
156
Bonn, Homburg
2019-11-13
Active, closed
Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma
NCT04099251Melanoma
DrugsOpdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
790
München, Bonn, Buxtehude, Dresden, Essen, Gera, Göttingen, Hanover
2019-10-28
Active, closed
Pazopanib Vs. Pazopanib Plus Gemcitabine
NCT02203760Leiomyosarcoma or Carcinosarcoma
DrugsPazopanib·Gemcitabine
North Eastern German Society of Gynaecological Oncology
Phase 2
58
Bonn, Berlin, Greifswald, Bad Saarow, Dresden, Essen, Jena, Tübingen
2019-10-16
Recruiting
Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders
NCT03981276Hereditary Spastic Paraplegia
Dr. Rebecca Schule
Observational
2,000
Bonn, Erlangen, Essen, Göttingen, Heidelberg, Lübeck, Magdeburg, München
2019-10-14
Active, closed
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
NCT03992404Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
DrugXeomin
Merz Pharmaceuticals GmbH
Phase 3
603
Aachen, Berlin, Bonn, Düsseldorf, Hamburg, Wiesbaden, Würzburg
2019-09-16
Active, closed
Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients
NCT04121455Glioblastoma
DrugsTemozolomide·Keytruda·Bevacizumab·Pembrolizumab
TME Pharma AG
Phase 1/2
117
Bonn, Essen, Leipzig, Mannheim, Münster, Tübingen
2019-09-12
Active, closed
Study of Standard Intensive Chemotherapy Versus Intensive Chemotherapy With CPX-351 in Adult Patients With Newly Diagnosed AML and Intermediate- or Adverse Genetics
NCT03897127Acute Myeloid Leukemia
DrugsLiposome-encapsulated Daunorubicin-Cytarabine·Daunorubicin·Cytarabine
University of Ulm
Phase 3
882
Aschaffenburg, Bad Saarow, Berlin, Bochum, Bonn, Braunschweig, Bremen, Darmstadt
2019-09-04
Recruiting
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma
NCT04043494Lymphoblastic Lymphoma, Childhood
DrugsVindesine·Thioguanine·PEG-Asparaginase·Mercaptopurine
University Hospital Muenster
Phase 3
683
Aachen, Augsburg, Berlin, Bielefeld, Bonn, Braunschweig, Bremen, Chemnitz
2019-08-23
Active, closed
TRILUMINATE Pivotal Trial
NCT03904147Tricuspid Regurgitation
Abbott Medical Devices
Not applicable
572
München, Bonn, Mainz, Leipzig
2019-08-21
Active, closed
Frontline Asciminib Combination in Chronic Phase CML
NCT03906292Chronic Myeloid Leukemia
DrugsAsciminib·Nilotinib·Dasatinib·Imatinib
University of Jena
Phase 2
125
Aachen, Berlin, Bonn, Bremen, Chemnitz, Dresden, Erlangen, Essen
2019-08-19
Active, closed
A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B
NCT03861273Hemophilia B
Pfizer
Phase 3
51
Berlin, Bonn
2019-07-29
Active, closed
Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)
NCT03924895Urinary Bladder Cancer, Muscle-invasive
DrugsEnfortumab Vedotin·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
595
Stuttgart, Tübingen, Erlangen, Munich, Würzburg, Bonn, Dresden, Magdeburg
2019-07-24
Active, closed
Transcatheter Repair of Tricuspid Regurgitation With Edwards Cardioband TR System Post Market Study (TriBAND)
NCT03779490Tricuspid Regurgitation, Tricuspid Insufficiency
Edwards Lifesciences
Observational
150
Ulm, Bad Oeynhausen, Cologne, Berlin, Bonn, Dresden, Erlangen, Göttingen
2019-07-24
Active, closed
Long Term Extension Study in Patients With Primary Hyperoxaluria
NCT04042402Primary Hyperoxaluria Type 1 (PH1), Primary Hyperoxaluria Type 2 (PH2), Kidney Diseases, Urologic Diseases
DrugDcr-Phxc
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Phase 3
75
Bonn, Heidelberg
2019-07-09
Active, closed
Effisayil™ ON: A Study to Test Long-term Treatment With Spesolimab in People With Generalized Pustular Psoriasis Who Took Part in a Previous Study
NCT03886246Generalized Pustular Psoriasis
DrugSpesolimab
LEO Pharma
Phase 2
131
Bad Bentheim, Berlin, Bonn, Erlangen, Frankfurt am Main, München, Münster, Oldenburg
2019-05-29
Recruiting
Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk
NCT04029363Mitral Regurgitation
HighLife SAS
Not applicable
120
Bad Krozingen, Bonn, Dresden, Hamburg, Heidelberg, Leipzig, Munich, Rostock
2019-05-28
Recruiting
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
NCT03686124Refractory Cancer, Recurrent Cancer, Solid Tumor, Adult, Cancer
DrugsAnzu-cel·Opdivo·Nivolumab
Immatics US, Inc.
Phase 1/2
375
Heidelberg, Munich, Würzburg, Bonn, Mainz, Dresden, Berlin, Hamburg
2019-05-14
Active, closed
Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment
NCT03847428Hepatocellular Carcinoma
DrugsAvastin·Durvalumab·Bevacizumab
AstraZeneca
Phase 3
908
Berlin, Bonn, Chemnitz, Cologne, Freiburg im Breisgau, Heidelberg, Leipzig, Lübeck
2019-04-29
By invitation
A Study Following Males With Haemophilia B on Prophylaxis With Refixia/REBINYN
NCT03745924Haemophilia B
DrugNonacog beta pegol
Novo Nordisk A/S
Observational
60
Berlin, Bonn
2019-04-01
Active, closed
Automatic PredICtion of Edema After Stroke
NCT04057690Stroke, Acute, Brain Edema
University Hospital Tuebingen
Observational
1,687
Berlin, Bonn, Bremen, Düsseldorf, Hamburg, Hanover, Heidelberg, Leipzig
2019-04-01
Active, closed
High Frequency Imaging in Cerebral Amyloid Angiopathy
NCT06128824Cerebral Amyloid Angiopathy
Martin Dichgans
Observational
75
Bonn, Magdeburg, Munich
2019-03-19
Active, closed
A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy
NCT03839771Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
DrugsEnasidenib·Ivosidenib
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
968
Bad Saarow, Berlin, Bochum, Bonn, Braunschweig, Bremen, Dortmund, Düsseldorf
2019-03-01
Active, closed
A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy
NCT03796962Focal Epilepsy
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 2
325
Berlin, Bielefeld, Bonn, Frankfurt, Freiburg im Breisgau, Münster, Osnabrück, Regensburg
2019-01-30
Active, closed
Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients
NCT03737643Advanced Ovarian Cancer
DrugsOlaparib·Durvalumab·Paclitaxel·Bevacizumab
AstraZeneca
Phase 3
1,407
Bad Homburg, Berlin, Bielefeld, Bonn, Brandenburg, Cologne, Dresden, Düsseldorf
2019-01-04
Active, closed
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
NCT03725059Breast Cancer
DrugsEpirubicin·Cytoxan·Adriamycin·Taxol
Merck Sharp & Dohme LLC
Phase 3
1,240
Friedrichshafen, Erlangen, Munich, Offenbach, Wiesbaden, Hanover, Bonn, Essen
2018-12-27
Active, closed
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
NCT03732677Muscle Invasive Bladder Cancer
DrugsDurvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,063
Bergisch Gladbach, Bonn, Cologne, Erlangen, Göttingen, Herne, Jena, Magdeburg
2018-11-16
Active, closed
Trial on the Effect of Isatuximab to Lenalidomide/Bortezomib/Dexamethasone (RVd) Induction and Lenalidomide Maintenance in Patients With Newly Diagnosed Myeloma (GMMG HD7)
NCT03617731Multiple Myeloma
DrugsVelcade·Isatuximab·Bortezomib·Lenalidomide
University of Heidelberg Medical Center
Phase 3
662
Aachen, Bad Saarow, Berlin, Bielefeld, Bochum, Bonn, Braunschweig, Chemnitz
2018-10-18
Active, closed
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
NCT03690388Differentiated Thyroid Cancer
DrugCabozantinib
Exelixis
Phase 3
187
Tübingen, Würzburg, Marburg, Hanover, Dresden, Magdeburg, Aachen, Bonn
2018-10-05
Recruiting
Extension Study for the Port Delivery System With Ranibizumab (Portal)
NCT03683251Neovascular Age-Related Macular Degeneration
DrugPDS Implant with Ranibizumab
Hoffmann-La Roche
Phase 3
1,000
Bonn, Cologne, Cottbus, Freiburg im Breisgau, Hamburg, Ludwigshafen, München, Münster
2018-09-20
Active, closed
A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
NCT03568318Atopic Dermatitis
DrugUpadacitinib
AbbVie
Phase 3
1,533
Heidelberg, Frankfurt am Main, Münster, Selters, Kiel, Bonn, Hamburg, Hanover
2018-08-09
Active, closed
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants
NCT03451851Psoriasis
DrugsEnbrel·Etanercept·Guselkumab
Janssen Research & Development, LLC
Phase 3
120
Bonn, Dresden, Frankfurt, Kiel, Langenau, Selters, Stuttgart
2018-07-11
Active, closed
AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System
NCT03339115Mitral Regurgitation, Mitral Valve Disease
Cardiovalve Ltd.
Not applicable
30
Bonn, Cologne, Lübeck, Mainz, München
2018-04-23
Active, closed
THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study
NCT02732704Aortic Regurgitation
JenaValve Technology, Inc.
Not applicable
100
Bad Nauheim, Bad Oeynhausen, Berlin, Bonn, Cologne, Frankfurt, Hamburg
2018-04-20
Active, closed
A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
NCT03383458Hepatocellular Carcinoma, Liver Cancer
DrugsOpdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
545
Aachen, Berlin, Bonn, Cologne, Essen, Frankfurt am Main, Hanover, Homburg
2018-04-18
Recruiting
The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)
NCT03949972Glomerulosclerosis, Focal Segmental, Minimal Change Disease, Idiopathic Nephrotic Syndrome
Prof. Dr. Paul Brinkkoetter
Observational
500
Cologne, Aachen, Berlin, Bonn, Dachau, Erlangen, Essen, Heidelberg
2018-04-01
Recruiting
Endometrial Cancer Lymphadenectomy Trial
NCT03438474Cancer of Endometrium Stage I, Cancer of Endometrium Stage II
Philipps University Marburg
Not applicable
640
Aalen, Amberg, Ansbach, Augsburg, Bad Homburg, Bamberg, Berlin, Bonn
2018-03-28
Active, closed
Development of Novel Clinical Endpoints in Intermediate AMD
NCT03349801Age Related Macular Degeneration (AMD)
Frank G. Holz
Observational
718
Bonn, Cologne, Freiburg im Breisgau, Munich, Münster, Tübingen, Ulm
2018-03-26
Recruiting
Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia A Patients
NCT03695978Haemophilia A
Octapharma
Observational
200
Berlin, Bonn, Duisburg, Essen, Frankfurt
2018-02-13
Recruiting
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
NCT03320304Treatment Resistant Depression
LivaNova
Observational
500
Bamberg, Bonn, Cologne, Essen, Frankfurt, Freiburg im Breisgau, Göttingen, Hanover
2017-12-14
Active, closed
Efficacy, Safety and Tolerability Study of Long-acting Cabotegravir Plus Long-acting Rilpivirine (CAB LA + RPV LA) in Human-immunodeficiency Virus-1 (HIV-1) Infected Adults
NCT03299049HIV Infections
DrugsRilpivirine·Cabotegravir
ViiV Healthcare
Phase 3
1,049
Berlin, Bonn, Essen, Frankfurt, Hamburg, Hanover, München
2017-10-27
Active, closed
Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone
NCT03104842Multiple Myeloma
DrugsIsatuximab·Carfilzomib·Lenalidomide·Dexamethasone
Universitätsklinikum Hamburg-Eppendorf
Phase 2
246
Berlin, Bielefeld, Bonn, Chemnitz, Cologne, Eschweiler, Essen, Hamburg
2017-08-15
Active, closed
Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents
NCT03206671Mature B-cell Non-Hodgkin Lymphoma
DrugsDoxorubicin Hydrochloride·Cytarabine·Etoposide·Dexamethasone
University Hospital Muenster
Phase 3
650
Aachen, Augsburg, Berg, Berlin, Bielefeld, Bonn, Braunschweig, Bremen
2017-08-03
Active, closed
Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET Patients
NCT03049189Neuroendocrine Tumors
Drugs177Lu-DOTATOC·Everolimus
ITM Solucin GmbH
Phase 3
324
Bad Berka, Berlin, Bonn, Erlangen, Essen, Hamburg, Magdeburg, Marburg
2017-02-02
Active, closed
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
NCT02960022Prostate Cancer
DrugsLeuprolide Acetate·Abiraterone acetate·Enzalutamide·Prednisone
Astellas Pharma Global Development, Inc.
Phase 2
900
Nürtingen, Waldshut-Tiengen, Mannheim, Duisburg, Bonn, Hamburg
2016-12-22
Active, closed
Ruxolitinib vs Allogeneic SCT for Patients With Myelofibrosis According to Donor Availability
NCT03333187Bone Marrow Fibrosis
DrugJakavi
Universitätsklinikum Hamburg-Eppendorf
Phase 2
87
Aachen, Berlin, Bonn, Düsseldorf, Halle, Hamburg, Jena, Mainz
2016-12-21
Active, closed
Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults
NCT02951052Infection, Human Immunodeficiency Virus, HIV Infections
Drugs2 NRTIs·Cabotegravir (CAB)·Rilpivirine (RPV)·Rilpivirine
ViiV Healthcare
Phase 3
618
Berlin, Bonn, Essen, Frankfurt, Hamburg, Hanover, München
2016-10-28
Active, closed
Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants
NCT02938520HIV Infections
DrugsCabotegravir (CAB)·Rilpivirine (RPV)·Rilpivirine·Cabotegravir
ViiV Healthcare
Phase 3
631
Berlin, Bonn, Essen, Frankfurt, Hamburg, Hanover, München
2016-10-27
Active, closed
Study to Evaluate Imetelstat (GRN163L) in Participants With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
NCT02598661Myelodysplastic Syndromes
DrugImetelstat sodium
Geron Corporation
Phase 2/3
289
Freiburg im Breisgau, Dresden, Leipzig, Aschaffenburg, Bonn, Düsseldorf, Mainz
2016-01-12
Recruiting
Non-Invasive Characterization of Focal Liver Lesions in Liver Cirrhosis
NCT03746210Liver Cirrhoses
University Hospital, Bonn
Observational
200
Bonn
2016-01-01
Active, closed
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
NCT02489318Prostate Cancer
DrugApalutamide
Aragon Pharmaceuticals, Inc.
Phase 3
1,052
Bonn, Braunschweig, Eisleben Lutherstadt, Hamburg, Hanover, Leipzig, Lübeck, Nürtingen
2015-11-27
Recruiting
Registry Study of Assistive Devices, Medicines and Healthcare Measures in ALS, SMA and Other Neurological Diseases.
NCT05852418Amyotrophic Lateral Sclerosis
Ambulanzpartner Soziotechnologie APST GmbH
Observational
25,000
Berlin, Bochum, Bonn, Dresden, Essen, Göttingen, Hanover, Heidelberg
2015-10-30
Active, closed
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma
NCT02066220Brain Tumors
Universitätsklinikum Hamburg-Eppendorf
Phase 2/3
360
Aachen, Augsburg, Berlin, Bielefeld, Bonn, Braunschweig, Bremen, Chemnitz
2014-06
Recruiting
The European Paediatric Network for Haemophilia Management ( PedNet Registry)
NCT02979119Factor VIII Deficiency, Factor IX Deficiency
PedNet Haemophilia Research Foundation
Observational
4,000
Berlin, Bonn, Bremen, Frankfurt, Frankfurt am Main, Munich
2014-06
Active, closed
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
NCT02032823Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
1,837
Aachen, Augsburg, Baden-Baden, Berlin, Bonn, Bottrop, Brandenburg, Bremen
2014-04-22
Recruiting
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
NCT01949129Acute Lymphoblastic Leukaemia
DrugsGrafalon·Treosulfan·Thiotepa·Busulfan
St. Anna Kinderkrebsforschung
Phase 2/3
1,800
Giessen, Aachen, Berlin, Bonn, Düsseldorf, Erlangen, Essen, Frankfurt am Main
2013-04
Recruiting
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
NCT01719055Pain
Boston Scientific Corporation
Observational
4,800
Berlin, Bonn, Cologne, Düsseldorf, München
2012-11-19
Active, closed
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).
NCT01586910Severe Aortic Stenosis
Medtronic Cardiovascular
Not applicable
1,746
Bad Krozingen, Bonn, Munich
2012-04
Recruiting
Register Schweres Asthma - German Asthma Net e.V.
NCT06035289Severe Asthma
German Asthma Net e.V.
Observational
4,500
Altdorf, Augsburg, Bad Windsheim, Bamberg, Berlin, Bielefeld, Bonn, Böblingen
2011-11-01
Active, closed
Observational Study on Determinants of Dementia After Stroke
NCT01334749Ischemic Stroke, Hemorrhagic Stroke
Ludwig-Maximilians - University of Munich
Observational
736
Munich, Berlin, Bonn, Göttingen, Magdeburg
2011-04
Recruiting
Registry Study on Patient Characteristics, Biological Disease Profile and Clinical Outcome in Acute Myeloid Leukemia and Related Neoplasms - The Biology and Outcome (BiO)-Project
NCT01252485Acute Myeloid Leukemia (AML), MDS/AML
University of Ulm
Observational
50,000
Aschaffenburg, Augsburg, Aurich, Bad Saarow, Berlin, Bochum, Bonn, Braunschweig
2010-07-06
Recruiting
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
NCT02701036Late Onset Sporadic Cerebellar Ataxia
Ataxia Study Group
Observational
300
Berlin, Bonn, Essen, Frankfurt, Hamburg, Magdeburg, München, Rostock
2010-04
Recruiting
Vascular Liver Disease Evaluation, Follow Up and Non-Invasive Diagnostics Program
NCT03717792Vascular Disorder of Liver
University Hospital, Bonn
Observational
500
Bonn
2010-01-01
Recruiting
Assessment of Transcatheter Edge-to-Edge Repair in Atrial Functional Mitral Regurgitation (ATRIAL-MR)
NCT06911099Atrial Functional Mitral Regurgitation, Mitral Insufficiency
University Hospital of Cologne
Observational
1,000
Munich, Cologne, Bad Oeynhausen, Bonn, Düsseldorf, Hamburg, Kiel, Leipzig
2010-01-01
Recruiting
Global Registry and Natural History Study for Mitochondrial Disorders
NCT05554835Mitochondrial Diseases, Kearns-Sayre Syndrome, MIDD, SANDO
LMU Klinikum
Observational
6,000
Munich, Berlin, Bonn, Cologne, Düsseldorf, Frankfurt am Main, Freiburg im Breisgau, Halle
2009-02-01
Recruiting
Pharmacokinetics of Antiretroviral Agents in HIV-infected Pregnant Women.
NCT00825929HIV Infections
Radboud University Medical Center
Observational
176
Berlin, Bonn, Cologne, Frankfurt am Main, München
2009-02
Active, closed
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
NCT00626990Brain and Central Nervous System Tumors
DrugsTemodal·Temodar·Temozolomide
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
751
Bamberg, Bonn, Hanover, Heidelberg, Regensburg, Tübingen
2007-12
Recruiting
Pompe Pregnancy Sub-Registry
NCT00567073Glycogen Storage Disease Type II (GSD-II), Pompe Disease (Late-onset), Glycogenesis 2 Acid Maltase Deficiency
Genzyme, a Sanofi Company
Observational
20
Bonn
2007-06-18
Active, closed
Panther: A Study Comparing Biweekly and Tailored EC-T Versus Three Weekly FEC-T in Breast Cancer Patients
NCT00798070Breast Cancer
DrugsFEC→T·Taxotere·Epirubicin·Fluorouracil
Karolinska University Hospital
Phase 3
2,017
Aachen, Bamberg, Bayreuth, Berlin, Bietigheim, Bonn, Böblingen, Celle
2007-02
Recruiting
The EUROSCA Natural History Study
NCT02440763Spinocerebellar Ataxia
Ataxia Study Group
Observational
400
Bochum, Bonn, Essen, Frankfurt, Tübingen
2005-07
Recruiting
Pompe Disease Registry Protocol
NCT00231400Glycogen Storage Disease Type II, Pompe Disease
Genzyme, a Sanofi Company
Observational
2,000
Berlin, Bochum, Bonn, Freiburg im Breisgau, Giessen, Halle, Hamburg, Mainz
2004-09-15
By invitation
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
NCT02699736HIV, Hepatitis B, Hepatitis C, AIDS
Rigshospitalet, Denmark
Observational
23,000
Bonn, Cologne, Eppendorf, Frankfurt am Main, Hamburg, Hanover, München
1994-01
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a German investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 30 September 2026. https://priyalifescience.com/clinical-trials-germany/city/bonn

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Germany and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 5,051 studies in total at the last sync on 26 Sep 2026, 19:51 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 413 of those studies with a site in Bonn.

How many clinical trials are recruiting in Bonn?

237 of the 413 studies on this page are recruiting new participants as of the 26 Sep 2026, 19:51 UTC sync. A further 10 have not yet opened recruitment, 155 are active but closed to new participants, and 11 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Bonn), 413 studies
PhaseStudiesRecruitingShare
Phase 31858944.8%
Observational987123.7%
Not applicable583614%
Phase 240239.7%
Phase 41062.4%
Phase 2/3932.2%
Phase 1741.7%
Phase 1/2651.5%

Most active sponsors

Lead sponsors with the most studies (Bonn)
Lead sponsorStudiesRecruiting
AstraZeneca3421
University Hospital, Bonn2422
University of Bonn128
Hoffmann-La Roche114
Boehringer Ingelheim96
Merck Sharp & Dohme LLC91
AbbVie82
Novo Nordisk A/S81
Incyte Corporation74
Pfizer62
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.