Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

NCT06574282 · tracked via the Priya Life Science Germany tracker

Sponsor

University of Bonn

Phase

Observational

Started

2024-08-25

Last updated

2025-02-10

Condition(s) studied

Hypophosphatasia

Investigational drug(s) / intervention(s)

Second alkaline phosphatase measurement

Second alkaline phosphatase measurement: (1-4 weeks after the 1st measurement)

Study summary

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Written informed consent * Age \> 18 years * Clinical suspicion of hypophosphatasia * Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening Exclusion Criteria: * Failure to meet the inclusion criteria listed above

Primary outcome measure(s)

Prevalence of hypophosphatasia in adult patients in rheumatology — 36 months
The primary aim of this prospective observational study is to determine the prevalence of hypophosphatasia in adult patients presenting with musculoskeletal symptoms in rheumatology.

Trial sites (1)

Facility	City	Region	Status
Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn	Bonn	North Rhine-Westphali	Recruiting

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Other trials for the same condition

Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06574282 on ClinicalTrials.gov ↗ ← All trials in Germany