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Clinical Trials in Germany / NCT06239064
Active, not recruiting Observational

Early Genetic Identification of Obesity

NCT06239064 · tracked via the Priya Life Science Germany tracker
Sponsor
Rolfs Consulting und Verwaltungs-GmbH (RCV)
Phase
Observational
Started
2024-01-24
Last updated
2025-09-29

Condition(s) studied

Obesity, ChildhoodHyperphagiaRetinopathySyndactylyPolydactylyCognitive ImpairmentBardet-Biedl SyndromePOMC Deficiency

Investigational drug(s) / intervention(s)

Genetic testing via blood collection

Genetic testing via blood collection: blood collection

Study summary

TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO)

DESIGN: Multicenter epidemiological study

STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl. participants clinically diagnosed with Bardet-Biedl-Syndrome (BBS)

NUMBER OF PARTICIPANTS: 1000 for initial genetic sequencing and app. 40 for the follow-up documentation

COORDINATING INVESTIGATOR: Prof. Dr. Arndt Rolfs

Eligibility

Sex
ALL
Min age
2 Years
Max age
—
Healthy volunteers
No
Inclusion criteria: * Informed consent is obtained from the participant/parent/legal guardian * The participant is 2 years of age or older For a participant between 2 and 18 years of age: * The participant has and had a body weight more than 97th percentile before the age of 6 * The participant has one or more of the following symptoms: rod/cone dystrophy, renal abnormalities, ataxia, syndactyly, polydactyly, brachydactyly, hyperphagia, cognitive impairment, speech delay, hypogonadism For a participant who is 18 years of age or older: * The participant has BMI ≥ 30 kg/m2 * The participant had a body weight more than 97th percentile before the age of 6 years * The participant has rod/cone dystrophy * The participant is 2 or more years of age, is clinically diagnosed with Bardet-Biedl-Syndrome (BBS) or is a sibling of an individual diagnosed with BBS via the WEGIO study Exclusion criteria: \- Not fulfilling the inclusion criteria

Primary outcome measure(s)

Trial sites (37)

FacilityCityRegionStatus
Universitätsklinikum Aachen (RWTH) Aachen Germany
KJF Klinik Josefinum Augsburg Germany
Universitätsklinikum Augsburg - Klinik für Kinder- und Jugendmedizin Augsburg Germany
Universitätsklinikum Freiburg Bad Krozingen Germany
Klinikum Bielefeld Mitte Bielefeld Germany
Universitätsklinikum Bonn Bonn Germany
Praxis für Endokrinologie Dr. Daniel Pfaff Bückeburg Germany
Cellitinnen-Krankenkaus St. Franziskus Cologne Germany
Universitätsmedizin Essen Essen Germany
Klinikum Frankfurt (Oder) Frankfurt (Oder) Germany
SRH Wald-Klinikum Gera Gera Germany
Universitätsmedizin Göttingen - Klinik für Kinder- und Jugendmedizin Göttingen Germany
WolfartKlinik Gräfelfing Germany
Universitätsmedizin Greifswald - Klinik und Poliklinik für Innere Medizin A Greifswald Germany
Katholisches Kinderkrankenhaus WILHELMSTIFT Hamburg Germany
Kinder- und Jugendkrankenhaus Auf der Bult Hanover Germany
Hormonzentrum Heidelberg Heidelberg Germany
Kinder- und Jugendarztpraxis Nebras Mohammad Iserlohn Germany
Universitätsklinikum Jena Jena Germany
Universitätsklinikum Schleswig-Holstein - Campus Kiel Kiel Germany
Sozialpädiatrisches Zentrum Leipzig Leipzig Germany
Universitätsmedizin Mannheim - Augenklinik Mannheim Germany
Städtische Kliniken Mönchengladbach - Elisabeth-Krankenhaus Rheydt Mönchengladbach Germany
Kinder- und Jugendarztpraxis Sulaiman Al Sawaf Nettetal Germany
Dietrich-Bonhoeffer-Klinikum Neubrandenburg Germany
Hausarztpraxis Rahman & Detho Obertshausen Germany
Sana Klinikum Offenbach Offenbach Germany
Kinderärzte am Leo Pforzheim Germany
Klinikum Ernst von Bergmann Potsdam Germany
Elblandklinikum Riesa Riesa Germany
GPR Klinikum Rüsselsheim Rüsselsheim am Main Germany
Kinder- und Jugendpraxis Dogan Stuttgart Germany
SRH Zentralklinikum Suhl GmbH Suhl Germany
Praxis für Kinder- und Jugendmedizin Dr. med. Tabea Tippelt Velbert Germany
Dreifaltigkeits-Krankenhaus Wesseling Wesseling Germany
Praxis für Kinder- und Jugendmedizin Seyfullah Gökce Wiesbaden Germany
Universitätsklinikum Würzburg - Medizinische Klinik und Poliklinik I Würzburg Germany

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06239064 on ClinicalTrials.gov ↗ ← All trials in Germany