Cognitive Training and Brain Stimulation in Women With Post-chemotherapy Cognitive Impairment

NCT04817566 · tracked via the Priya Life Science Germany tracker

Sponsor

University Medicine Greifswald

Phase

Not applicable

Started

2021-11-02

Last updated

2025-04-04

Condition(s) studied

Breast CancerCognitive Impairment

Investigational drug(s) / intervention(s)

Anodal tDCSSham tDCSIntensive cognitive training

Anodal tDCS: Anodal transcranial direct current stimulation (tDCS), 9 sessions with 20 minutes stimulation each (2 mA).

Sham tDCS: Sham transcranial direct current stimulation (tDCS), 9 sessions with 30 sec stimulation each (2 mA) to ensure blinding of participants.

Intensive cognitive training: Intensive cognitive training of a letter memory updating task, 9 sessions for approximately 20 min

Study summary

The aim of this study is to investigate whether a high definition tDCS-accompanied intensive cognitive training of working memory leads to performance improvement in women with post-chemotherapy cognitive impairment after breast cancer treatment.

Eligibility

Sex

FEMALE

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: 1. Chemotherapy to treat breast cancer (≥ 6 months post-treatment). 2. Self-reported concerns regarding cognitive functioning. 3. Age: 18-65 years. 4. right-handedness Exclusion Criteria: 1. History of dementia before treatment of cancer. 2. Other neurodegenerative neurological disorders; epilepsy or history of seizures. 3. Severe and untreated medical conditions that preclude participation in the training, as determined by responsible physician. 4. History of moderate to severe substance use disorder according to DSM-5 5. Moderate to severe acute psychiatric disorders according to DSM-5 6. Contraindication to tDCS application (Antal et al., 2017)

Primary outcome measure(s)

Working memory performance at post-assessment — 3 weeks
Performance in a near transfer task (n-back) under anodal tDCS compared to sham condition; operationalized by % correct responses in the n-back task

Trial sites (1)

Facility	City	Region	Status
University Medicine Greifswald	Greifswald	Germany	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04817566 on ClinicalTrials.gov ↗ ← All trials in Germany