Physical Exercise: 30 min of cycling on an ergometer, moderate or high intensity
Control Intervention: 30 min of watching a movie
Study summary
The aim of the proposed project is to investigate the effects of a single session of physical exercise on stress regulation, cognitive and emotional functioning, and associated neurophysiological processes (saliva and blood samples) in patients with borderline personality disorder. A further aim is to identify the optimal exercise intensity (moderate vs. high intensity). The investigatiors expect that acute exercise will lead to positive effects on behavioral and biomarker level.
Eligibility
Sex
ALL
Min age
18 Years
Max age
50 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* estimated verbal intelligence quotient \>80 (MWT-B; Lehrl 2005)
* patients: diagnosis of borderline personality disorder according to DSM-5
Exclusion Criteria:
* neurological disorders
* health conditions interfering with exercise safety, e.g. coronary heart disease
* visual impairments that may interfere with performance of the cognitive tasks
* endocrine disorders, e.g. hyperthyreosis or diabetes mellitus;
* following psychiatric disorders: psychosis or affective disorders with psychotic symptoms, schizophrenia, substance abuse or dependence, autism spectrum disorders, anorexia nervosa;
* healthy controls: BPD, intake of psychotropic drugs
Primary outcome measure(s)
change in cognitive interference — directly before and 10 minutes after exercise and control condition classical color-word Stroop task: reaction time difference between congruent and incongruent stimuli, difference between pre- and post-intervention is compared between exercise and control condition
change in subjective stress perception — stress test 90 minutes after exercise and control condition, subjective stress scale are collected before stress test and 0, 10, 20, and 30 minutes after stress test Trier social stress test: subjective stress level (visual analogue scale rated from 0=noperceived stress to 9=highest perceived stress), changes between pre-stress and post-stress are compared between exercise and control condition
change in cortisol levels — stress test 90 minutes after exercise and control condition, saliva samples are collected before stress test and 0, 10, 20, and 30 minutes after stress test Trier social stress test: cortisol levels measured in saliva; changes between pre-stress and post-stress (cortisol peak expected at 20 minutes after stress test) are compared between exercise and control condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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