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Trackers› Clinical trials› Tennessee
Clinical trial register · United States · industry-sponsored

Clinical Trials in Tennessee, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
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Trials with a site in Tennessee

670 of 9118 studies
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Phase
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US states
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Recruiting
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
Loxo Oncology, Inc.
Phase 3
737
California, Florida, Louisiana, Maryland, Montana, Pennsylvania, South Carolina, Tennessee
2022-07-22
Active, closed
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
NCT05296798Locally Advanced or Metastatic Breast Cancer
Hoffmann-La Roche
Phase 3
922
Arizona, California, Florida, Maryland, Tennessee, Texas, Washington
2022-07-18
Active, closed
Long-term Follow-up Study of Patients Who Received hLB-001 Gene Therapy
NCT05506254Methylmalonic Acidemia
Alexion Pharmaceuticals, Inc.
Observational
4
Georgia, Pennsylvania, Tennessee, Washington
2022-07-15
Recruiting
Otoferlin Gene-mediated Hearing Loss Natural History Study
NCT05572073Sensorineural Hearing Loss, Bilateral
Akouos, Inc.
Observational
150
Iowa, Ohio, Pennsylvania, Tennessee
2022-07-14
Recruiting
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.
NCT05401357Glaucoma, Open-Angle, Ocular Hypertension
Amneal Pharmaceuticals, LLC
Phase 3
168
California, Florida, Georgia, Tennessee, Texas, Wyoming
2022-06-29
Recruiting
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
NCT05462106Amyloid Plaque, Beta-Amyloid, DSAD, Prodromal Alzheimer's Disease
AC Immune SA
Phase 1/2
304
Arizona, Florida, Indiana, Kansas, Massachusetts, Missouri, North Carolina, Tennessee
2022-06-21
Active, closed
An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients With Hepatic Dominant Ocular Melanoma
NCT05022901Metastatic Ocular Melanoma, Metastatic Uveal Melanoma
Delcath Systems Inc.
Phase 3
30
California, Florida, North Carolina, Ohio, Tennessee
2022-06-10
Active, closed
A Study of Talquetamab and Teclistamab Each in Combination With a Programmed Cell Death Receptor-1 (PD-1) Inhibitor for the Treatment of Participants With Relapsed or Refractory Multiple Myeloma
NCT05338775Relapsed/ Refractory Multiple Myeloma
Janssen Research & Development, LLC
Phase 1
74
Colorado, New York, North Carolina, Tennessee
2022-05-25
By invitation
Posterior Cervical Fixation Study
NCT04770571Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
NuVasive
Observational
150
California, Connecticut, Maryland, New York, Pennsylvania, Tennessee, Texas
2022-05-10
Active, closed
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)
NCT05356195Beta-Thalassemia, Thalassemia, Genetic Diseases, Inborn, Hematologic Diseases
Vertex Pharmaceuticals Incorporated
Phase 3
16
Tennessee
2022-05-03
Active, closed
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hemoglobinopathies
Vertex Pharmaceuticals Incorporated
Phase 3
13
North Carolina, Pennsylvania, Tennessee
2022-05-02
Active, closed
EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT)
NCT05444894Transfusion Dependent Beta Thalassemia, Hemoglobinopathies, Thalassemia Major, Thalassemia Intermedia
Editas Medicine, Inc.
Phase 1/2
9
California, Minnesota, New York, Ohio, Pennsylvania, Tennessee
2022-04-29
Active, closed
A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol
NCT06809218Post-Intensive Care Syndrome, Sedation
Sedana Medical
Phase 3
312
Tennessee
2022-04-22
By invitation
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
NCT05303532Cancer
AstraZeneca
Phase 3
214
California, Colorado, Tennessee
2022-04-19
Recruiting
Use of CereGate Therapy for Freezing of Gait in PD
NCT05292794Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
CereGate Inc.
Not applicable
41
California, Colorado, Florida, Illinois, North Carolina, Tennessee, Washington
2022-04-18
Recruiting
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
NCT05267626Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma, Non-Small Cell Lung Cancer
Aulos Bioscience, Inc.
Phase 1/2
159
Florida, Michigan, Minnesota, Missouri, North Carolina, Tennessee, Texas, Utah
2022-04-04
Active, closed
Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC
NCT05301842Hepatocellular Carcinoma
AstraZeneca
Phase 3
760
Alabama, Arizona, California, Georgia, Maryland, New Mexico, New York, Tennessee
2022-03-28
Active, closed
Non-Guided vs. Guided Surgery to Immediately Loaded PrimeTaper Implants in Partially Edentulous Patients
NCT05264545Partially Edentulous Maxilla or Mandible
McGuire Institute
Not applicable
100
Colorado, Illinois, Nebraska, Tennessee, Texas, Washington, Wisconsin
2022-03-22
Recruiting
Trisol System EFS Study
NCT04905017Tricuspid Regurgitation
Trisol Medical
Not applicable
30
California, Georgia, New York, Ohio, Pennsylvania, Tennessee, Virginia
2022-03-02
Active, closed
A Phase 3 Single-Arm Study of UGN-102 for Treatment of Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer
NCT05243550Bladder Cancer, Urothelial Carcinoma, Urothelial Carcinoma Bladder
UroGen Pharma Ltd.
Phase 3
240
Arizona, California, Kansas, Maryland, Missouri, New Jersey, New York, Tennessee
2022-03-01
Active, closed
A Study to Evaluate ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)
NCT05222802Glioblastoma Multiforme
Katmai Pharmaceuticals Inc.
Phase 1
52
California, Florida, Massachusetts, Michigan, New York, Ohio, Tennessee, Utah
2022-02-25
Active, closed
Insignia™ Hip Stem Outcomes Study
NCT05144191Hip Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-traumatic Osteoarthritis
Stryker Orthopaedics
Not applicable
313
Arizona, California, Illinois, Nevada, New York, North Carolina, Pennsylvania, Tennessee
2022-02-07
Active, closed
Safety and Immunogenicity of CRV-101 Vaccine for the Prevention of Herpes Zoster in Adults Aged 50 Years and Older
NCT05304351Herpes Zoster, Shingles
Curevo Inc
Phase 2
1,516
Arizona, Florida, Illinois, Kansas, Kentucky, Nevada, Oklahoma, Tennessee
2022-02-02
Active, closed
Tumor-induced Osteomalacia Disease Monitoring Program
NCT04783428Tumor-induced Osteomalacia (TIO)
Ultragenyx Pharmaceutical Inc
Observational
23
Connecticut, Indiana, Maryland, Tennessee, Virginia
2022-01-31
Active, closed
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
NCT05002127Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma
ALX Oncology Inc.
Phase 2/3
127
California, Tennessee, Virginia, Washington
2022-01-15
Active, closed
A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies
NCT05199272Solid Tumor, Clear Cell Renal Cell Carcinoma, Epithelial Ovarian Cancer, Fallopian Tube Cancer
23andMe, Inc.
Phase 1/2
141
California, Georgia, Michigan, New York, Oregon, Tennessee, Texas, Virginia
2021-12-29
Active, closed
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
NCT05197036Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Smith & Nephew, Inc.
Observational
299
Georgia, Massachusetts, Michigan, New York, North Carolina, Oregon, South Carolina, Tennessee
2021-12-21
Active, closed
A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT04819100Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company
Phase 3
152
California, Florida, Massachusetts, Minnesota, New York, Pennsylvania, Tennessee, Texas
2021-12-20
By invitation
Extension Study of Infigratinib in Children With Achondroplasia (ACH)
NCT05145010Achondroplasia
QED Therapeutics, a BridgeBio company
Phase 2
300
California, Colorado, Delaware, Maryland, Missouri, Ohio, Tennessee, Wisconsin
2021-12-06
Active, closed
Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus Erythematosus
NCT05039840Systemic Lupus Erythematosus
Sanofi
Phase 2
109
Alabama, Arizona, California, Florida, New Mexico, New York, Oklahoma, Tennessee
2021-11-10
Active, closed
Electrical Muscle Stimulation with 1064 Nm Diode Laser and RF/PEMF for Non-invasive Body Contouring and Fat Reduction.
NCT05256771Fat Reduction, Muscle Tone Increased
Venus Concept
Not applicable
36
California, New Jersey, Tennessee
2021-11-01
Active, closed
Cone Beam Breast CT for Breast Cancer Screening
NCT05036096Breast Cancer
Koning Corporation
Not applicable
1,024
Florida, Georgia, Tennessee
2021-10-30
Recruiting
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
NCT05099172Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation
Bayer
Phase 1/2
400
Arizona, California, Georgia, Maryland, Massachusetts, Michigan, New York, Tennessee
2021-10-25
By invitation
Multi-Center Clinical Database of Infants for the Investigation of Early Nutrition Biomarkers
NCT05049655Infant Development
ByHeart
Observational
2,000
Alabama, Arizona, Arkansas, Idaho, Ohio, South Carolina, Tennessee, Utah
2021-10-19
Active, closed
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
NCT04971226Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive
Novartis Pharmaceuticals
Phase 3
405
Colorado, Florida, Kentucky, Massachusetts, North Carolina, Oregon, South Dakota, Tennessee
2021-10-06
Active, closed
A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
NCT04931654Carcinoma, Non-Small-Cell Lung, Gastric Cancer, Gastroesophageal Junction Cancer
AstraZeneca
Phase 1/2
136
Georgia, Indiana, New York, Tennessee
2021-09-28
Active, closed
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease
NCT04884815Wilson Disease
Ultragenyx Pharmaceutical Inc
Phase 1/2
82
California, Illinois, Indiana, Massachusetts, Michigan, North Carolina, Ohio, Tennessee
2021-09-27
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors
NCT04774718ALK Fusion-positive Solid or CNS Tumors
Hoffmann-La Roche
Phase 1/2
42
California, Florida, Michigan, Minnesota, New York, Ohio, Tennessee
2021-09-14
Active, closed
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
NCT04747431Frontotemporal Dementia, FTD, FTD-GRN, Dementia Frontotemporal
Passage Bio, Inc.
Phase 1/2
30
Michigan, Pennsylvania, Tennessee, Texas
2021-09-14
Active, closed
Phase 1 Study of Autologous CD30.CAR-T in Relapsed or Refractory CD30 Positive Non-Hodgkin Lymphoma
NCT04526834Anaplastic Large Cell Lymphoma, Peripheral T Cell Lymphoma, Extranodal NK/T-cell Lymphoma, Diffuse Large B Cell Lymphoma
Tessa Therapeutics
Phase 1
21
California, Tennessee, Texas
2021-09-08
Active, closed
Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC
NCT04919811Non Small Cell Lung Cancer
Nuvation Bio Inc.
Phase 2
217
California, Florida, Louisiana, Minnesota, New Jersey, Ohio, Tennessee, Texas
2021-09-01
Active, closed
Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced Solid Tumors
NCT05007782Advanced Solid Tumor
Gilead Sciences
Phase 1
304
California, Connecticut, Massachusetts, Tennessee, Texas, Wisconsin
2021-08-18
Recruiting
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
NCT04913285Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
Pierre Fabre Medicament
Phase 1
400
California, Colorado, Florida, Minnesota, New Jersey, New York, Ohio, Tennessee
2021-08-04
Active, closed
EFS of the CardioMech MVRS
NCT04820764Mitral Regurgitation
CardioMech AS
Not applicable
35
California, Illinois, Kansas, Minnesota, New York, North Carolina, Ohio, Tennessee
2021-07-27
Active, closed
CYPRESS Efficacy and Safety Study Extension
NCT04947735Juvenile Myopia, Myopia
SightGlass Vision, Inc.
Not applicable
200
California, Florida, Kansas, Louisiana, Missouri, New York, South Dakota, Tennessee
2021-07-19
Recruiting
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
NCT04900818Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer
I-Mab Biopharma US Limited
Phase 1
330
California, Colorado, Indiana, Massachusetts, New Jersey, New York, North Carolina, Tennessee
2021-06-29
Recruiting
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer
NCT04802759Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
Hoffmann-La Roche
Phase 1/2
316
California, Massachusetts, New Jersey, North Carolina, Pennsylvania, Tennessee
2021-06-22
Active, closed
FHD-286 as Monotherapy or Combination Therapy in Subjects With Advanced Hematologic Malignancies
NCT04891757Advanced Hematologic Malignancy, Relapsed Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia, Relapsed Myelodysplastic Syndromes
Foghorn Therapeutics Inc.
Phase 1
144
California, Massachusetts, New York, Tennessee, Texas
2021-06-14
Active, closed
A Prospective Study to Observe & Describe Clinical Outcomes of Alglucosidase Alfa Treatment in Patients ≤6 Months of Age With Infantile-onset Pompe Disease (IOPD)
NCT04848779Glycogen Storage Disease Type II
Sanofi
Observational
16
New York, North Carolina, Ohio, Tennessee, Washington
2021-06-10
Recruiting
A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer
NCT04872166Advanced Solid Tumor, Metastatic Breast Cancer
Edgewood Oncology Inc.
Phase 1
112
Florida, Ohio, Tennessee, Texas
2021-06-07
Recruiting
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
NCT04895709Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer
Bristol-Myers Squibb
Phase 1/2
1,109
California, Iowa, New Jersey, New York, Oregon, Tennessee, Texas
2021-05-27
Recruiting
A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
NCT04830137Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Waldenstrom Macroglobulinemia (WM), Mantle Cell Lymphoma (MCL)
Nurix Therapeutics, Inc.
Phase 1
248
California, Colorado, Florida, Illinois, Maryland, New York, Ohio, Tennessee
2021-05-05
Active, closed
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
NCT04868877Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Merus B.V.
Phase 1/2
194
California, Tennessee, Utah, Virginia
2021-04-28
Active, closed
Antibody Persistence And Long Term Safety Of A Chikungunya Virus Vaccine (VLA1553)
NCT04838444Chikungunya Virus Infection
Valneva Austria GmbH
Phase 3
363
Arizona, Florida, Illinois, Kentucky, Nebraska, Tennessee, Texas, Utah
2021-04-02
Recruiting
Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System
NCT04634916Kidney Disease, End-Stage, End-stage Renal Disease, Arteriovenous Fistula
C. R. Bard
Not applicable
220
California, Florida, Massachusetts, New York, North Carolina, Ohio, Pennsylvania, Tennessee
2021-03-26
Active, closed
Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection
NCT04727788Kidney Transplant Rejection
Verici Dx
Observational
550
Illinois, Maryland, Michigan, Nebraska, Ohio, Pennsylvania, Tennessee, Washington
2021-03-21
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
BioNTech SE
Phase 2
327
California, Indiana, Minnesota, Ohio, Rhode Island, Tennessee, Texas, Virginia
2021-03-08
Recruiting
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
NCT04678648Advanced Malignant Solid Neoplasm, RAS Mutation, Lung Cancer, Colon Cancer
RasCal Therapeutics, Inc.
Phase 1
134
California, Colorado, Tennessee
2021-03-03
Active, closed
Phase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/Refractory Hodgkin Lymphoma (CHARIOT)
NCT04268706Hodgkin Lymphoma, Adult, Hodgkin Disease Recurrent, Hodgkin Disease Refractory, Hodgkin Disease, Pediatric
Tessa Therapeutics
Phase 2
97
California, Illinois, Pennsylvania, Tennessee, Texas
2021-02-01
By invitation
A Long-term Follow-up Study in Participants Who Received CTX001
NCT04208529Beta-Thalassemia, Thalassemia, Sickle Cell Disease, Hematologic Diseases
Vertex Pharmaceuticals Incorporated
Phase 3
160
California, Illinois, New York, North Carolina, Pennsylvania, Tennessee, Texas
2021-01-20
Active, closed
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
NCT04657991Melanoma
Pfizer
Phase 3
257
Florida, Kansas, Massachusetts, Ohio, Tennessee
2021-01-15
Active, closed
Growth Trial: Study of the Renata Minima Stent
NCT05086016Coarctation of the Aorta, Pulmonary Artery Stenosis
Renata Medical
Not applicable
42
California, Massachusetts, Ohio, Tennessee, Washington
2021-01-14
Active, closed
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia
Amgen
Phase 1/2
181
California, Illinois, Maryland, Michigan, New York, Pennsylvania, Tennessee, Texas
2021-01-04
Recruiting
Collection of Samples USOPTIVAL Study
NCT04792684Colorectal Cancer (CRC), Advanced Adenomas (AA)
Universal Diagnostics
Observational
1,300
California, Florida, Illinois, Louisiana, Massachusetts, New York, Pennsylvania, Tennessee
2020-12-30
Active, closed
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
NCT04538742Metastatic Breast Cancer
AstraZeneca
Phase 1/2
245
Florida, New York, Ohio, Tennessee, Texas, Virginia
2020-12-28
Active, closed
A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors
NCT04707248Renal Cell Carcinoma, Ovarian Tumor
DrugR-DXd
Daiichi Sankyo
Phase 1
179
Arizona, Colorado, Florida, Oklahoma, Tennessee
2020-12-22
Active, closed
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
NCT04305795Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head-and-neck Squamous-cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
Rakuten Medical, Inc.
Phase 1/2
23
Florida, Kentucky, Minnesota, Oregon, Pennsylvania, Tennessee, Texas
2020-12-21
Active, closed
A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer
NCT04556773Metastatic Breast Cancer
AstraZeneca
Phase 1
138
New York, North Carolina, Tennessee, Texas
2020-12-17
Active, closed
Beating Heart Mitral Valve Repair With the HARPOON™ System
NCT04375332Mitral Regurgitation
Edwards Lifesciences
Not applicable
25
California, Georgia, Maryland, Michigan, Minnesota, Oregon, Tennessee, Utah
2020-12-16
Recruiting
Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities
NCT04683250RET-altered Non Small Cell Lung Cancer, RET-altered Solid Tumors
Taiho Pharmaceutical Co., Ltd.
Phase 1/2
244
California, Massachusetts, Michigan, New York, Tennessee, Texas
2020-12-16
Active, closed
Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
NCT04645212Wet Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
Adverum Biotechnologies, Inc.
Observational
23
California, Colorado, Florida, Nevada, Pennsylvania, Tennessee, Texas
2020-12-14
Active, closed
A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)
NCT04471727Small-Cell Lung Cancer, Neuroendocrine Carcinoma
Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 1/2
232
California, Colorado, Massachusetts, Michigan, New York, Ohio, Oregon, Tennessee
2020-12-14
Recruiting
Evaluate the Continued Safety and Performance of the Foot and Ankle Products
NCT04715139Hyperpronated Foot, Reconstruction Surgeries of the Foot, Fixation of Fractures and Fusion (Bunionectomy Osteotomies) of the Foot/Ankle, Fixation of Small Bone Fragments of the Foot/Ankle
Arthrex, Inc.
Observational
700
California, Illinois, Tennessee, Texas, Virginia
2020-12-01
Active, closed
Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations
NCT04603001Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), Myeloproliferative Neoplasms (MPNs)
Eli Lilly and Company
Phase 1
260
California, Florida, Illinois, Massachusetts, New York, North Carolina, Tennessee, Texas
2020-11-19
Active, closed
Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
NCT04592913Gastrointestinal Neoplasms, Esophagogastric Junction
AstraZeneca
Phase 3
957
California, Florida, Indiana, Kentucky, Massachusetts, New York, Tennessee, Texas
2020-11-17
Recruiting
Study of PF-07248144 in Advanced or Metastatic Solid Tumors
NCT04606446Locally Advanced or Metastatic ER+ HER2- Breast Cancer, Locally Advanced or Metastatic Castration-resistant Prostate Cancer, Locally Advanced or Metastatic Non-small Cell Lung Cancer
Pfizer
Phase 2
320
Arizona, California, Connecticut, Florida, Kentucky, Tennessee, Texas, Washington
2020-11-16
Active, closed
A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies
NCT04606381Neoplasms
Janssen Research & Development, LLC
Phase 1
158
California, Indiana, New York, Oregon, Tennessee
2020-11-10
Recruiting
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
NCT04329728Lymphoid Malignancies
AVM Biotechnology Inc
Phase 1/2
144
California, Florida, Illinois, Kentucky, Nebraska, Ohio, Tennessee, Texas
2020-11-06
Active, closed
A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies
NCT04072458Mantle Cell Lymphoma, Peripheral T-cell Lymphoma (PTCL), Cutaneous T-cell Lymphoma (CTCL), Chronic Lymphocytic Leukemia (CLL)
DrugBP1002
Bio-Path Holdings, Inc.
Phase 1
30
Georgia, New York, Tennessee, Texas
2020-11-05
Active, closed
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)
NCT04524871Advanced Liver Cancers
Hoffmann-La Roche
Phase 1/2
518
California, Colorado, Connecticut, District of Columbia, Kentucky, Oregon, Tennessee, Texas
2020-11-01
Recruiting
A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer
NCT04516447Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Phase 1
172
Colorado, Massachusetts, Missouri, New York, North Carolina, Rhode Island, Tennessee, Texas
2020-10-26
Recruiting
Abbott Vascular Medical Device Registry
NCT04573660Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism
Abbott Medical Devices
Observational
3,784
Alabama, Arkansas, California, Illinois, Nebraska, Ohio, Tennessee
2020-10-25
Active, closed
Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma
NCT04484623Multiple Myeloma
GlaxoSmithKline
Phase 3
302
Arizona, Florida, Massachusetts, Missouri, Tennessee
2020-10-01
Active, closed
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
NCT04557449Liposarcoma, Prostate Cancer, Breast Neoplasms, Adenocarcinoma of Lung
Pfizer
Phase 2
362
California, Connecticut, Massachusetts, Michigan, Tennessee, Texas
2020-09-23
Active, closed
NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS
NCT04623944Relapsed/Refractory AML, AML, Adult, MDS, Refractory Myelodysplastic Syndromes
Nkarta, Inc.
Phase 1
61
Colorado, Florida, Georgia, Illinois, Ohio, Tennessee, Texas
2020-09-21
Recruiting
A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies
NCT04503265Advanced Malignant Neoplasm, Breast Cancer, Ovarian Cancer, Homologous Recombination Deficiency
AtlasMedx, Incorporated
Phase 1/2
122
California, Maryland, Tennessee, Texas
2020-08-12
Active, closed
A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma
NCT04522323Advanced Renal Cell Carcinoma
MedImmune LLC
Phase 1
67
District of Columbia, Florida, Missouri, New York, Ohio, Pennsylvania, Tennessee
2020-08-05
Active, closed
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
NCT04561362Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms
BicycleTx Limited
Phase 1/2
329
Colorado, Florida, New York, Ohio, Pennsylvania, Tennessee, Texas
2020-07-17
Active, closed
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
NCT04478279Glioblastoma, Melanoma Stage IV, Breast Cancer, Prostate Cancer
Sapience Therapeutics
Phase 1/2
125
California, Colorado, Illinois, Michigan, New York, North Carolina, Tennessee
2020-07-01
Active, closed
Episealer® Knee System IDE Clinical Study
NCT04000659Degenerative Lesion of Articular Cartilage of Knee
Episurf Medical Inc.
Not applicable
13
Arizona, California, Louisiana, New Jersey, New York, Ohio, Tennessee, Texas
2020-06-18
Active, closed
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
NCT04270409Plasma Cell Myeloma
Sanofi
Phase 3
337
California, Colorado, Florida, Massachusetts, North Carolina, Tennessee, Texas
2020-06-16
Active, closed
Long-Term Prospective Registry in Prostate Cancer Patients From Diverse Urology Practice Settings Following Prolaris® Testing
NCT04404894Prostate Cancer
Myriad Genetic Laboratories, Inc.
Observational
500
Alabama, California, Florida, Illinois, Maryland, Tennessee
2020-04-30
Active, closed
A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer
NCT04214288Advanced ER-Positive HER2-Negative Breast Cancer
AstraZeneca
Phase 2
240
Alabama, California, Florida, Nebraska, Ohio, Tennessee, Wisconsin
2020-04-22
Active, closed
A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer
NCT04288089Receptors, Estrogen, Genes, Erbb-2, Breast Neoplasms
Eisai Inc.
Phase 1
31
Florida, Massachusetts, Missouri, Nevada, Tennessee
2020-04-01
Active, closed
A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma
NCT04108195Multiple Myeloma
Janssen Research & Development, LLC
Phase 1
290
California, New York, North Carolina, Pennsylvania, Tennessee, Wisconsin
2020-02-21
Active, closed
TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations
NCT04129502Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Takeda
Phase 3
354
California, Florida, Illinois, Maryland, Massachusetts, Tennessee, Virginia
2020-01-10
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
NCT04082429Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors
Novo Nordisk A/S
Phase 3
156
California, Georgia, Indiana, Iowa, Michigan, North Carolina, Pennsylvania, Tennessee
2019-11-13
Active, closed
A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation)
NCT04111458Solid Tumors, KRAS Mutation; SOS1
Boehringer Ingelheim
Phase 1
71
Massachusetts, North Carolina, Tennessee, Texas
2019-11-04
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
NCT04083781Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
Novo Nordisk A/S
Phase 3
134
California, Georgia, Indiana, Missouri, North Carolina, Tennessee, Texas
2019-10-21
Recruiting
Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
NCT04150497B-cell Acute Lymphoblastic Leukemia
Cellectis S.A.
Phase 1/2
52
California, Colorado, Illinois, Massachusetts, New York, Pennsylvania, Tennessee, Texas
2019-10-14
Active, closed
Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments
NCT04056247Stage IV Non-small Cell Lung Cancer, Stage IV Malignant Melanoma, Stage IV Small Cell Lung Cancer, Stage III Unresectable Non-Small Cell Lung Cancer
OncoHost Ltd.
Observational
10,000
Alabama, Florida, Illinois, Iowa, New Jersey, New York, Tennessee, Texas
2019-10-01
Active, closed
Clinical Trial to Evaluate Zevor-cel (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)
NCT03915184Multiple Myeloma
CARsgen Therapeutics Co., Ltd.
Phase 1/2
105
Arizona, California, Colorado, Florida, Massachusetts, Minnesota, Tennessee, Texas
2019-09-25
Active, closed
COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
NCT04068610Metastatic Microsatellite-stable Colorectal Cancer
MedImmune LLC
Phase 1/2
61
California, Michigan, Nevada, New York, Ohio, Rhode Island, Tennessee, Texas
2019-09-13
Recruiting
Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
NCT03945162Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
Theralase® Technologies Inc.
Phase 2
90
Illinois, Indiana, New York, Ohio, Pennsylvania, South Carolina, Tennessee, Texas
2019-08-30
Active, closed
ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)
NCT04044859Endometrial Cancer, Esophageal Cancer, Esophagogastric Junction (EGJ), Gastric (Stomach) Cancer
USWM CT, LLC
Phase 1
120
Florida, Massachusetts, Missouri, New York, North Carolina, Oklahoma, Tennessee, Texas
2019-08-20
Active, closed
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
NCT03814746Sickle Cell Disease (SCD)
Novartis Pharmaceuticals
Phase 3
254
Georgia, Massachusetts, North Carolina, Tennessee, Texas
2019-07-26
Active, closed
Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL
NCT03960840Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia
Novartis Pharmaceuticals
Phase 1/2
217
California, Florida, Illinois, Kansas, Massachusetts, Pennsylvania, Tennessee, Texas
2019-06-26
Active, closed
An Extension Study to Evaluate Safety and Efficacy of BMN 111 in Children With Achondroplasia
NCT03989947Achondroplasia
BioMarin Pharmaceutical
Phase 2
73
California, Delaware, Georgia, Illinois, Ohio, Tennessee, Texas, Wisconsin
2019-06-12
By invitation
Long-term Follow-Up Study of RGX-314 and Fellow Eye Substudy
NCT03999801Neovascular Age-related Macular Degeneration, Wet Macular Degeneration
AbbVie
Phase 2
865
Arizona, California, Maryland, Massachusetts, Nevada, Pennsylvania, Tennessee, Texas
2019-05-31
Recruiting
Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
NCT05181826Cancer, Liver Cirrhosis, Chronic Hepatitis, Hepatitis B
Helio Genomics
Observational
1,200
California, Minnesota, Tennessee, Texas
2019-05-21
Active, closed
Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.
NCT03891953Carcinoma, Non-Small-Cell Lung, Melanoma, Nasopharyngeal Carcinoma, Microsatellite Stable Colorectal Cancer
Novartis Pharmaceuticals
Phase 1
98
Massachusetts, Tennessee
2019-05-07
Active, closed
Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer
NCT03907852Mesothelioma, Mesothelioma, Malignant, Mesothelioma; Pleura, Mesotheliomas Pleural
TCR2 Therapeutics
Phase 1/2
57
California, Florida, Illinois, Maryland, New York, North Carolina, Pennsylvania, Tennessee
2019-04-15
Recruiting
Two Dose Levels of Privigen in Pediatric CIDP
NCT03684018Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
CSL Behring
Phase 4
30
Arizona, California, Iowa, Ohio, Pennsylvania, Tennessee, Texas, Virginia
2019-02-28
Active, closed
The CONFORMAL Early Feasibility Study
NCT03616028Non-valvular Atrial Fibrillation
Conformal Medical, Inc
Not applicable
64
Arkansas, California, New Hampshire, New York, Ohio, Pennsylvania, Tennessee, Texas
2019-02-22
By invitation
The Informed Genetics Annotated Patient Registry
NCT04419896Predisposition, Genetic
Medneon
Observational
10,000
California, Illinois, Michigan, Tennessee, Texas
2019-01-23
Active, closed
A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC
NCT03819465Metastatic Non-Small Cell Lung Cancer (NSCLC)
AstraZeneca
Phase 1
175
Iowa, Pennsylvania, Tennessee
2018-12-27
Active, closed
Study of Durvalumab+Olaparib or Durvalumab After Treatment With Durvalumab and Chemotherapy in Patients With Lung Cancer (ORION)
NCT03775486Non-small Cell Lung Cancer NSCLC
AstraZeneca
Phase 2
401
Florida, Missouri, Pennsylvania, Tennessee, Texas
2018-12-21
Recruiting
Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles
NCT03793348Wrinkle
Cytrellis Biosystems, Inc.
Not applicable
35
California, Colorado, Florida, New York, Tennessee, Texas
2018-11-12
Active, closed
Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101
NCT03741127Multiple Myeloma
Poseida Therapeutics, Inc.
Phase 1
100
California, Colorado, Illinois, Kansas, Maryland, Michigan, Pennsylvania, Tennessee
2018-10-29
Active, closed
A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
NCT03596645Colitis, Ulcerative
Janssen Research & Development, LLC
Phase 3
84
California, Colorado, Connecticut, Delaware, Georgia, Minnesota, New York, Tennessee
2018-10-29
Active, closed
Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer.
NCT03616587ER+ HER2- Advanced Breast Cancer
AstraZeneca
Phase 1
396
Colorado, Florida, Pennsylvania, Tennessee, Utah
2018-10-11
Active, closed
A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)
NCT03634540Renal Cell Carcinoma (RCC), Clear Cell Renal Cell Carcinoma (ccRCC), Kidney Cancer, Renal Cancer
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
118
California, Florida, Massachusetts, Michigan, Tennessee, Texas, Washington
2018-09-27
Active, closed
Post-Market Study of Comprehensive Reverse Augmented Glenoid and Mini Humeral Tray in Total Shoulder Arthroplasty
NCT03726554Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects
Zimmer Biomet
Not applicable
99
Florida, Kentucky, Michigan, New York, Tennessee, Virginia
2018-08-28
Active, closed
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
NCT03687593Total Knee Arthroplasty
Smith & Nephew, Inc.
Observational
126
Minnesota, Nevada, South Carolina, Tennessee
2018-08-26
Active, closed
Control of Myopia Using Novel Spectacle Lens Designs
NCT03623074Juvenile Myopia
SightGlass Vision, Inc.
Not applicable
266
California, Florida, Kansas, Louisiana, Missouri, New York, South Dakota, Tennessee
2018-07-16
Active, closed
A Study of Runimotamab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers
NCT03448042Solid Tumors
Genentech, Inc.
Phase 1
123
Connecticut, Michigan, New York, Tennessee, Texas
2018-06-06
Recruiting
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
NCT03564340Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer
Regeneron Pharmaceuticals
Phase 1/2
890
Alabama, Massachusetts, Minnesota, New York, Ohio, Oklahoma, Tennessee, Texas
2018-05-21
Active, closed
A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
NCT03401788VHL - Von Hippel-Lindau Syndrome, VHL Gene Mutation, VHL Syndrome, VHL Gene Inactivation
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
50
Maryland, Massachusetts, Michigan, Pennsylvania, Tennessee, Texas, Utah
2018-05-02
Active, closed
A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors
NCT03530397Selected Advanced Solid Tumors
MedImmune LLC
Phase 1
400
Michigan, New York, North Carolina, Rhode Island, Tennessee, Virginia
2018-04-24
Active, closed
A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer
NCT03440450Advanced Solid Tumors, Biliary Tract Cancer
Fujifilm Pharmaceuticals U.S.A., Inc.
Phase 1
90
Arizona, California, Colorado, Tennessee, Texas, Washington
2018-03-22
Active, closed
A Study of Durvalumab Alone and Durvalumab+Olaparib in Advanced, Platinum-Ineligible Bladder Cancer (BAYOU)
NCT03459846Urinary Bladder Neoplasms
AstraZeneca
Phase 2
154
Alabama, Arizona, Florida, Kentucky, New York, Pennsylvania, Tennessee, Washington
2018-03-16
Active, closed
First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)
NCT03401385Hormone Receptor Positive Breast Cancer, Triple Negative Breast Cancer, Non-small Cell Lung Cancer
Daiichi Sankyo Co., Ltd.
Phase 1
890
California, District of Columbia, Georgia, Maryland, Massachusetts, New York, Tennessee, Texas
2018-01-31
Active, closed
Dose Escalation Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT03399799Hematological Malignancies
Janssen Research & Development, LLC
Phase 1
279
Alabama, California, Colorado, New York, Tennessee
2017-12-16
Active, closed
U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
NCT03260491Non-Small Cell Lung Cancer (NSCLC)
Daiichi Sankyo
Phase 1
312
California, Georgia, Massachusetts, Michigan, New York, Ohio, Pennsylvania, Tennessee
2017-10-30
Active, closed
Savolitinib vs. Sunitinib in MET-driven PRCC.
NCT03091192Carcinoma, Carcinoma, Renal Cell, Kidney Neoplasms, Urologic Neoplasms
AstraZeneca
Phase 3
60
California, Georgia, Illinois, Iowa, Massachusetts, Missouri, New York, Tennessee
2017-07-25
Active, closed
A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
NCT03162536Lymphoma, B-Cell, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Phase 1/2
190
Arizona, California, Colorado, Michigan, Minnesota, North Carolina, Ohio, Tennessee
2017-06-26
Active, closed
Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
NCT03164616Non Small Cell Lung Cancer NSCLC
AstraZeneca
Phase 3
1,186
Arizona, California, Florida, Kentucky, Missouri, Ohio, Pennsylvania, Tennessee
2017-06-01
Active, closed
MAGE-A4ᶜ¹º³²T for Multi-Tumor
NCT03132922Urinary Bladder Cancer, Melanoma, Head and Neck Cancer, Ovarian Cancer
USWM CT, LLC
Phase 1
71
Florida, Missouri, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2017-05-15
Active, closed
INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections
NCT03037164Anemia
Cerus Corporation
Phase 3
692
Arizona, Connecticut, Florida, Georgia, Maryland, Nevada, Tennessee, Texas
2017-05-11
Active, closed
A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC
NCT03052608Carcinoma, Non-Small-Cell Lung
Pfizer
Phase 3
296
Florida, Massachusetts, New York, Tennessee, Washington
2017-04-27
Active, closed
A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors
NCT02988960Advanced Solid Tumors Cancer
AbbVie
Phase 1
163
California, Illinois, Massachusetts, North Carolina, Tennessee, Texas, Virginia
2017-02-22
Active, closed
Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor
NCT03069469Advanced Malignant Neoplasm, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor
Deciphera Pharmaceuticals, LLC
Phase 1/2
120
California, Colorado, Florida, Massachusetts, New York, Oregon, Tennessee
2017-02-16
Active, closed
Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer
NCT02546661Muscle Invasive Bladder Cancer
AstraZeneca
Phase 1
117
California, Connecticut, Florida, New York, Ohio, Tennessee
2016-12-28
Active, closed
Ribociclib (LEE011) Rollover Study for Continued Access
NCT02934568Continued Access to Study Treatment(s), Cancers With a Mass, Bulky Tumor, Nodule, Lump, Advanced Cancer, Advanced Solid Tumors, Advanced Solid Malignancies
Novartis Pharmaceuticals
Phase 2
22
Alabama, Massachusetts, Michigan, New York, Tennessee
2016-12-15
Active, closed
An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib
NCT02955940Pancreatic Cancer, Colorectal Cancer (CRC), Breast Cancer, Lung Cancer
Incyte Corporation
Phase 2
10
California, Kentucky, New York, Tennessee, Texas
2016-11-30
Active, closed
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
NCT02932150Chronic Hepatitis B
Gilead Sciences
Phase 2
150
California, Colorado, Indiana, Maryland, Missouri, New York, Ohio, Tennessee
2016-11
Active, closed
Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1
NCT02881320HIV-1 Infection
Gilead Sciences
Phase 2/3
177
District of Columbia, Florida, Georgia, Michigan, New York, North Carolina, Pennsylvania, Tennessee
2016-09-21
Active, closed
A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer
NCT02747004Metastatic Breast Cancer
Eli Lilly and Company
Phase 2
234
Arizona, New Hampshire, Tennessee, Texas, Wisconsin
2016-09-14
Active, closed
14022 ATTUNE Cementless RP Clinical Performance Evaluation
NCT02839850Osteoarthritis
DePuy Orthopaedics
Not applicable
540
Colorado, Florida, New Hampshire, New Jersey, New York, North Carolina, Tennessee, Texas
2016-09-01
Active, closed
A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer
NCT02711553Biliary Tract Cancer, Metastatic Cancer, Advanced Cancer
Eli Lilly and Company
Phase 2
309
Arizona, California, District of Columbia, Florida, Michigan, Missouri, Pennsylvania, Tennessee
2016-05-19
Active, closed
A Study of Acalabrutinib in Combination With Rituximab + (Bendamustine or Venetoclax) in Subjects With MCL
NCT02717624Mantle Cell Lymphoma (MCL)
Acerta Pharma BV
Phase 1
72
Kentucky, Michigan, New Jersey, New York, Ohio, Tennessee, Texas, Washington
2016-04-20
Active, closed
A Study of ACP-196 (Acalabrutinib) in Subjects With Relapsed/Refractory CLL and Intolerant of Ibrutinib Therapy
NCT02717611Chronic Lymphocytic Leukemia
Acerta Pharma BV
Phase 2
60
Arizona, California, District of Columbia, Illinois, New York, Ohio, Tennessee, Texas
2016-03-08
Active, closed
Open-label Study to Evaluate Long-term Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule)
NCT02736656Attention-Deficit/Hyperactivity Disorder
Supernus Pharmaceuticals, Inc.
Phase 3
1,400
Arkansas, California, Colorado, Florida, Oklahoma, Tennessee, Texas, Utah
2016-02-02
Active, closed
A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH)
NCT02724228Achondroplasia
BioMarin Pharmaceutical
Phase 2
30
California, Illinois, Maryland, Tennessee, Texas
2016-01-26
Active, closed
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children
NCT02637687Solid Tumors Harboring NTRK Fusion
Bayer
Phase 1/2
154
California, Florida, Massachusetts, New York, Ohio, Pennsylvania, Tennessee, Texas
2015-12-16
Recruiting
Clinical Outcomes Study of the Nexel Total Elbow
NCT02469662Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis
Zimmer Biomet
Not applicable
134
Colorado, North Carolina, Pennsylvania, Tennessee
2015-06
Active, closed
An Open-label, Phase 2 Study of ACP-196 in Subjects With Waldenström Macroglobulinemia
NCT02180724Waldenström Macroglobulinemia (WM)
Acerta Pharma BV
Phase 2
107
California, Colorado, District of Columbia, Minnesota, New York, Tennessee, Texas, Washington
2014-09-11
Active, closed
Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia
NCT02157324Chronic Lymphocytic Leukemia
Acerta Pharma BV
Phase 1
12
Ohio, Tennessee, Texas
2014-08-18
Active, closed
AZD9291 in Combination With Ascending Doses of Novel Therapeutics
NCT02143466Advanced Non Small Cell Lung Cancer
AstraZeneca
Phase 1
344
Georgia, Massachusetts, New York, Pennsylvania, Tennessee
2014-08-05
Active, closed
Persona Total Knee Arthroplasty Outcomes Study
NCT02255383Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
737
Colorado, Illinois, Indiana, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2014-07
Active, closed
Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV
NCT02016924Acquired Immune Deficiency Syndrome (AIDS), HIV Infections
Gilead Sciences
Phase 2/3
133
California, Colorado, District of Columbia, Florida, Tennessee, Texas
2014-01-16
Active, closed
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer
NCT01872260Breast Cancer
Novartis Pharmaceuticals
Phase 1/2
259
California, Florida, Massachusetts, Tennessee, Texas, Washington
2013-10-22
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Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/tennessee?page=2

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 670 of those studies with a site in Tennessee.

How many clinical trials are recruiting in Tennessee?

371 of the 670 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 24 have not yet opened recruitment, 252 are active but closed to new participants, and 23 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.